CN108014078A - The method that adhesive composition and the bad medicine of compressibility are processed into predetermined hardness and brittle tablet - Google Patents
The method that adhesive composition and the bad medicine of compressibility are processed into predetermined hardness and brittle tablet Download PDFInfo
- Publication number
- CN108014078A CN108014078A CN201610950220.XA CN201610950220A CN108014078A CN 108014078 A CN108014078 A CN 108014078A CN 201610950220 A CN201610950220 A CN 201610950220A CN 108014078 A CN108014078 A CN 108014078A
- Authority
- CN
- China
- Prior art keywords
- adhesive composition
- tablet
- compressibility
- medicine
- predetermined hardness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
Abstract
Use a kind of adhesive composition, by directly compressing, a kind of tablet of the bad medicine of compressibility is manufactured, the adhesive composition be a kind of polymer, it is preferably a kind of defined the polyvinylpyrrolidone (PVP) of glass transition temperature (Tg) and the copolymer of vinyl acetate (VA), and mix a kind of the plasticizer such as organic ester or polyol of at least 10 DEG C of the Tg reductions that can make the copolymer；The adhesive composition and the medicine are directly compressible into a kind of predetermined hardness and brittle tablet with acceptable compression stress.
Description
Technical field
The present invention relates to directly compressing for the bad medicine of compressibility, more specifically to a kind of new of such medicine
With improved adhesive composition, said composition enables its mixture by directly compressing and being processed into institute to be subjected to compression stress
Wish hardness and brittle medicinal tablet.
Background technology
The bad medicine of compressibility such as naproxen and paracetamol are currently that tablet is made with wet granulation；So
And, there is provided it is a kind of by directly compress-i.e. the method for the tablet of the such medicine of commercial more advantageous approach-formation a kind of can be
Favourable.
The content of the invention
The tablet of the bad medicine of compressibility is directly to compress manufacture by using a kind of adhesive composition, the binding agent
Composition is a kind of for example more vinyl pyrrolidones (PVP) of polymer and vinyl acetate for having defined glass transition temperature (Tg)
Copolymer, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and the polyvinylpyrrolidone of ester (VA) and it can make described common
The Tg of polymers reduces the mixture of at least 10 DEG C of effective dose plasticizer；The adhesive composition and medicine are mixed, and passed through
Shape is directly compressible into as a kind of tablet using acceptable compression stress；Obtained tablet favourable hardness and brittleness；It is preferable common
Polymers is 60wt%PVP and 40wt%VA, its Tg is 106 DEG C, and plasticizer is when with about 1~25wt%, preferable 5~15wt%
It can make the Tg of this copolymer reduce at least 20 DEG C in the presence of quantity is mixed；Representative plasticizer includes polyethylene glycol, lemon
Triethylenetetraminehexaacetic acid ester, acetylated fatty acid glyceride, castor oil, dibutyl phthalate, diethyl phthalate, decanedioic acid two
Butyl ester, glycerine, glycerin monostearate, glyceryl triacetate, polyoxyethylene/polyoxypropylene copolymer and propane diols；Preferably
Plasticizer is organic ester and polyol, for example, triethyl citrate and polyethylene glycol；In general, which is one
The free flowing powder that kind particle mean size is about 30~90 μm；Typical mal-compression medicine is naproxen or to second in the present invention
Acylamino- phenol；The method of the present invention be by about 1~25wt% adhesive compositions, at least 50wt%, it is preferable 50~
What the directly compression of 90wt% medicines, the mixture that remaining is other excipient carried out；Directly pressed with about 3000~7000 ft lbfs
Contracting provide a kind of hardness at least about 8Kp, generally 8~20Kp and brittleness be about less than 3%, preferable 1~3% tablet.
Claims (1)
1. the bad medicinal tablet of compressibility directly compresses manufacture method, this method includes providing a kind of adhesive composition, should
Composition includes a kind of one group selected from following composition, has defined the polymer of glass transition temperature (Tg) and can make the copolymerization
The Tg of thing reduces the mixture polyvinylpyrrolidone (PVP) and vinyl acetate of a kind of at least 10 DEG C of a effective amount of plasticizer
The copolymer of ester (VA), hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone；Make the binding agent
Composition and medicine mixing；There is predetermined hardness and brittle with by forming one kind to be subjected to compression stress directly compression
Tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610950220.XA CN108014078A (en) | 2016-11-03 | 2016-11-03 | The method that adhesive composition and the bad medicine of compressibility are processed into predetermined hardness and brittle tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610950220.XA CN108014078A (en) | 2016-11-03 | 2016-11-03 | The method that adhesive composition and the bad medicine of compressibility are processed into predetermined hardness and brittle tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108014078A true CN108014078A (en) | 2018-05-11 |
Family
ID=62070811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610950220.XA Pending CN108014078A (en) | 2016-11-03 | 2016-11-03 | The method that adhesive composition and the bad medicine of compressibility are processed into predetermined hardness and brittle tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108014078A (en) |
-
2016
- 2016-11-03 CN CN201610950220.XA patent/CN108014078A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180511 |
|
| WD01 | Invention patent application deemed withdrawn after publication |