CN108007914A - Authenticity of medicament decision-making system and authenticity of medicament decision method - Google Patents
Authenticity of medicament decision-making system and authenticity of medicament decision method Download PDFInfo
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- CN108007914A CN108007914A CN201610964543.4A CN201610964543A CN108007914A CN 108007914 A CN108007914 A CN 108007914A CN 201610964543 A CN201610964543 A CN 201610964543A CN 108007914 A CN108007914 A CN 108007914A
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Abstract
Present invention aims at establish one make it that quickly detection is no longer limited medicine by instrument, method etc., efficiently, accurately, objectively provides the authenticity of medicament decision-making system and authenticity of medicament decision method of analysis result.Authenticity of medicament decision-making system provided by the invention, is connected with spectrum data gathering system and standard spectrum storage system, including：Spectrum acquisition device, for receiving medicine spectrum and the corresponding original spectral data that spectrum data gathering system is sent, and receives standard pharmaceutical spectrum and the corresponding standard spectral data that standard spectrum storage system is sent；Spectrum quantity judgment means, whether the number for the medicine spectrum for judging to receive is in the range of predetermined quantity；When judging in the range of predetermined quantity, spectral quality detection device carries out medicine spectrum quality testing, and qualified medicine spectrum is determined as qualified spectrum；Spectrum compares decision maker, for qualified spectrum to be compared with standard pharmaceutical spectrum, judges the true and false of medicine.
Description
Technical field
Present invention relates particularly to a kind of authenticity of medicament decision-making system and authenticity of medicament decision method.
Background technology
At present, medicine inspection department relies primarily on quick detection test paper, kit, near-infrared spectrum technique etc. to determine whether being
True medicine, but these detection method universalities are not strong, are mutually authenticated without result, and it be easy to cause erroneous judgement.
Compared with above-mentioned analyzing detecting method, spectroscopic methodology usually have the characteristics that it is quick, accurate, lossless, can micro-zone analysis,
Have broad application prospects in drugs analysis field.And with the development of technology, the portable spectrometer device of miniaturization by
Gradually popularize, the operation interface of hommization causes layman to operate, using instrument, while the instrument of some companies is matched somebody with somebody
Spectral analysis software is cased with, the spectrum that user collects can be differentiated.
But the operator and user of the spectrometer of one line of basic unit, often non-specialized-technical personnel, using spectrum
When the analysis software or third party software that instrument provides analyze spectroscopic data, the quality of collection spectrum have ignored.And
The feature of actual sample is different, and the response to instrument is also not quite similar, and being also by the method for clear and definite experiment parameter one by one can not
Can.Therefore, in actual mechanical process, sample collector needs to collect that what kind of spectrum just meets wanting for subsequent analysis on earth
Ask, be also sometimes indefinite, so lose time significantly, human and material resources.Moreover, it is to obtain that spectrum, which has good quality,
The accurately and reliably important prerequisite of analysis result and guarantee, but present situation is, and spectral analysis software is typically focused on the light to high quality
Modal data is analyzed, and is not concerned with whether spectrum to be analyzed has good quality substantially.
In addition, existing spectrum compares, determination rate of accuracy is not high, and in face of complicated analysis scene with analysis object when, it is past
Differentiate toward that intelligent cannot provide as a result, so can not effectively be analyzed for the counterfeit drug spread unchecked.The whole world has tens of every year
Ten thousand people are died of using counterfeit drug.This numeral as more counterfeit drugs enter market it is also possible to rise.Detecting and close down counterfeit drug needs
Time, manpower and the resources costs of costliness are expended, so a kind of quick detection and analysis medicine in short supply, and medicine is carried out true and false
The system of judgement.
The content of the invention
The present invention is to carry out to solve the above-mentioned problems, it is therefore intended that establishes an authenticity of medicament decision-making system, makes
Medicine quickly detection is no longer limited by instrument, method etc., efficiently, it is accurate, objectively provide analysis result, and provide one kind
Authenticity of medicament decision method.
The present invention provides a kind of authenticity of medicament decision-making system, is with spectrum data gathering system and standard spectrum storage
System connection, for judging the true and false of medicine, has the feature that, including：Spectrum acquisition device, is adopted for receiving spectroscopic data
Medicine spectrum that collecting system is sent and it is corresponding with the medicine spectrum and at least containing shift value, intensity level, noise figure,
Auxiliary material information, company-information, batch information and the original spectrum number with the corresponding maximum range value of spectrum data gathering system
According to, and receive standard pharmaceutical spectrum that standard spectrum storage system sends and with the corresponding standard of standard pharmaceutical spectrum
Spectroscopic data；Whether spectrum quantity judgment means, judge the number for the medicine spectrum that spectrum acquisition device receives in predetermined number
In the range of amount；When judging in the range of predetermined quantity, spectral quality detection device carries out medicine spectrum quality testing, and will close
The medicine spectrum of lattice is determined as qualified spectrum；Spectrum compares decision maker, for qualified spectrum and standard pharmaceutical spectrum to be carried out
Compare, judge the true and false of medicine, wherein, spectral quality detection device includes：Receiving division, receives medicine spectrum and original spectrum
Data；First obtains judging part, maximum displacement value and least displacement value is obtained from original spectral data, and judge whether to meet
Least displacement value is less than predetermined lower bound value, and maximum displacement value is more than the first condition of predetermined upper limit value；First configuration part, works as judgement
When meeting first condition, medicine spectrum is set as first condition qualification spectrum；Second obtains judging part, from original spectral data
Maximum intensity value is obtained, and judges whether to meet the second condition that maximum intensity value is less than maximum range value；Second configuration part, when
When judgement meets second condition, medicine spectrum is set as second condition qualification spectrum；3rd obtains judging part, according to predetermined acquisition
Rule obtains the maximum of predetermined quantity from the intensity level of original spectral data, and using the maximum as characteristic peaks, together
When obtain with the corresponding noise figure of this feature peak value, and judge whether to meet the ratio of characteristic peaks and noise figure in predetermined ratio
Third condition in the range of value；3rd configuration part, when judging to meet third condition, it is qualified as third condition to set medicine spectrum
Spectrum；And determination unit, when medicine spectrum is set to first condition qualification spectrum, second condition qualification spectrum, third condition
During qualified spectrum, judge that medicine spectrum is qualified spectrum.
Authenticity of medicament decision-making system provided by the invention, also has the feature that：Wherein, spectrum compares decision maker bag
Include：Standard excipients spectrum acquisition unit, obtains all standard excipients spectrum that the transmission of standard excipients spectrum thesaurus comes；Similar value meter
Calculation portion, calculates the similarity value between qualified spectrum and each standard excipients spectrum respectively；Similarity value sequence portion, according to phase
Standard excipients spectrum is ranked up like the size of angle value, obtains auxiliary material ranking information；Auxiliary material information acquiring section, from auxiliary material ranking
The spectrum auxiliary material information of predetermined ranking is obtained in information, and the auxiliary material information of medicine is obtained from qualified spectroscopic data；Comparison is sentenced
Disconnected portion, the auxiliary material information of spectrum auxiliary material information and the same ranking of medicine is compared one by one, and is judged whether consistent；First result
Configuration part, when judging consistent, sets medicine as the first qualified medicine；Producer spectrum search acquisition unit, according to company-information from
All standard pharmaceutical spectrum of corresponding same producer are obtained in standard pharmaceutical library of spectra, similar value calculating part calculates finally respectively
Similarity value between spectrum and all standard pharmaceutical spectrum of same company-information, average similarity value calculating part, calculates most
Average similarity value between whole spectrum and the standard pharmaceutical spectrum of same company-information, average similarity value judging part, judges
Whether in predetermined average value ranges, the second result configuration part, when being judged as YES, sets medicine as second to average similarity value
Qualified medicine, result judgement portion, when medicine is set to the first qualified medicine, the second qualified medicine, judges that medicine is true medicine.
In authenticity of medicament decision-making system provided by the invention, it can also have the feature that：Wherein, when first obtains
Judging part judgement is unsatisfactory for first condition, the second acquisition judging part judges to be unsatisfactory for second condition or the 3rd acquisition judging part
When judgement is unsatisfactory for third condition, determination unit judges that medicine spectrum is unqualified spectrum, and spectrum acquisition device is sentenced determination unit
Determine result and be sent to spectrum data gathering system.
In authenticity of medicament decision-making system provided by the invention, it can also have the feature that：Wherein, when spectrum quantity
When judgment means judge the number of medicine spectrum not in the range of predetermined quantity, spectral quality detection device is not to original spectrum number
According to quality testing is carried out, the judging result of spectrum quantity judgment means is sent to spectrum data gathering system by spectrum acquisition device
System.
In authenticity of medicament decision-making system provided by the invention, it can also have the feature that：Wherein, predetermined lower bound value
For any one value in 150 to 250, predetermined upper limit value is any one value in 2500~2700, and predetermined ratio scope is 2
To 100, between predetermined threshold is 2000 to 10000 and be 100 integral multiple arbitrary value.
In authenticity of medicament decision-making system provided by the invention, it can also have the feature that：Wherein, predetermined ranking is
Any one numerical value in 3~6, predetermined number be 5~20 in any one numerical value, make a reservation for obtain rule be using maximum in
The heart, when intensity level declines in the serial number on intensity level rising while the right in the serial number on the left side of maximum, setting
Maximum is characterized peak value, and serial number is any one numerical value in 4~9.
In authenticity of medicament decision-making system provided by the invention, it can also have the feature that：Wherein, when the first result
Configuration part do not set medicine as the first qualified medicine or the second result configuration part do not set medicine as the second qualified medicine when, knot
Fruit determination unit judges that medicine is counterfeit drug.
Present invention also offers a kind of authenticity of medicament decision method, have the feature that：Receive spectrum data gathering
Medicine spectrum that system is sent and with the corresponding original spectral data of medicine spectrum, and receive standard spectrum storage system
Unite the standard pharmaceutical spectrum that sends and with the corresponding standard spectral data of standard pharmaceutical spectrum；Judge that spectrum acquisition fills
The number of the medicine spectrum received is put whether in the range of predetermined quantity；When judging in the range of predetermined quantity, medicine is received
Spectrum and original spectral data；Maximum displacement value and least displacement value are obtained from original spectral data, and is judged whether full
Sufficient least displacement value is less than predetermined lower bound value, and maximum displacement value is more than the first condition of predetermined upper limit value；When judgement meets first
During condition, medicine spectrum is set as first condition qualification spectrum；Maximum intensity value is obtained from original spectral data, and judgement is
The no second condition for meeting maximum intensity value and being less than maximum range value；When judge meet second condition when, set medicine spectrum as
Second condition qualification spectrum；The very big of predetermined quantity is obtained from the intensity level of original spectral data according to the predetermined rule that obtains
Value, and regard the maximum as characteristic peaks, while obtain and the corresponding noise figure of this feature peak value, and judge whether to meet
Third condition of the ratio of characteristic peaks and noise figure in the range of predetermined ratio；When judging to meet third condition, medicine is set
Product spectrum is third condition qualification spectrum；And when medicine spectrum is set to first condition qualification spectrum, second condition qualification
When spectrum, third condition qualification spectrum, judge that medicine spectrum is qualified spectrum, obtain what the transmission of standard excipients spectrum thesaurus came
All standard excipients spectrum；The similarity value between qualified spectrum and each standard excipients spectrum is calculated respectively；According to similar
The size of angle value is ranked up standard excipients spectrum, obtains auxiliary material ranking information；Obtain from auxiliary material ranking information and name in advance
Secondary spectrum auxiliary material information, and from qualified spectroscopic data obtain medicine auxiliary material information；By spectrum auxiliary material information and medicine
The auxiliary material information of same ranking compares one by one, and judges whether consistent；When judging consistent, medicine is set as the first qualified medicine
Product；Searched for according to active ingredient information from standard active ingredient spectrum thesaurus and obtain corresponding standard active ingredient spectrum；
It is characterized according to the predetermined maximum for obtaining rule and predetermined quantity being obtained from intensity level, and by the peak setting where the maximum
Peak；Calculate the characteristic peak of the characteristic peak and standard active ingredient spectrum of the predetermined number of qualified spectrum in the range of same shift value
Matching value；Judge whether matching value is qualified；When judging qualified, medicine is set as the second qualified medicine；When medicine is set
For the first qualified medicine, the second qualified medicine when, judge that medicine is true medicine.
The effect of invention
Involved authenticity of medicament decision-making system according to the present invention, because having spectral quality detection device and spectrum ratio
To decision maker, so on the one hand the authenticity of medicament decision-making system of the present invention can be believed by spectral region, maximum range value, spectrum
Ratio, the spectral intensity etc. of making an uproar are controlled spectral quality, to ensure that the spectral quality of sample meets the requirement of subsequent analysis,
Also the experiment parameter in sample collector's practical operation is set to give at the same time and instructed, so as to greatly improve work efficiency and follow-up point
Analyse the accuracy of result；On the other hand, spectrum compare decision maker in, standard excipients spectrum acquisition unit, similar value calculating part,
Similarity value sequence portion, auxiliary material information acquiring section, contrast judgement portion and the first result configuration part form the first judgment mode, factory
Family's spectrum search acquisition unit, average similarity value calculating part, average similarity value judging part and the second result configuration part are formed
Second judgment mode, so, authenticity of medicament decision-making system of the invention is by the first judgment mode from auxiliary material information level analysis
The constituent of medicine, can verify whether auxiliary material and its component explanation unanimously judge medicine according to matched auxiliary material result
The true and false, while in terms of medicine spectrum dissect by the second judgment mode and judge medicine, and then sentence to medicine progress is true and false
It is fixed；In addition, two kinds of judgment modes are separate, it does not interfere with each other, knot can be further improved to avoid error caused by extraneous factor
The accuracy that fruit judges.
In addition, the authenticity of medicament decision-making system of the present invention is truly realized simplification, intelligence, networking, high efficiency etc.
Function, it is to the technical requirements of operating personnel not high and can in time feedback operation personnel the problem of where, from time, place
Limitation, efficiently realizes that information, data and classical analysis scheme are shared.
Brief description of the drawings
Fig. 1 is the block diagram of medicine identification system in the embodiment of the present invention；
Fig. 2 is the block diagram of medicine identification system in the embodiment of the present invention；
Fig. 3 is the block diagram of spectral quality detection device in the embodiment of the present invention；
Fig. 4 is the Raman spectrum for meeting first condition；
Fig. 5 is the Raman spectrum for not meeting second condition；
Fig. 6 is the Raman spectrum for meeting third condition；
Fig. 7 is the block diagram that spectrum compares decision maker in the embodiment of the present invention；
Fig. 8 is that similar value calculating part calculates similarity value between qualified spectrum and each standard excipients spectrum respectively；
Fig. 9 is the action flow chart of the authenticity of medicament decision-making system of the embodiment of the present invention；
Figure 10 is the action flow chart of the spectral quality detection device of the embodiment of the present invention；And
Figure 11 is that the spectrum of the embodiment of the present invention compares the action flow chart of decision maker.
Embodiment
It is real below in order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention easy to understand
Example combination attached drawing is applied to be specifically addressed authenticity of medicament decision-making system of the present invention.
Fig. 1 is the block diagram of medicine identification system in the embodiment of the present invention.
As shown in Figure 1, authenticity of medicament judges that system 100 includes spectrum data gathering system 200 and the spectrum data gathering
The authenticity of medicament decision-making system 300 and the standard spectrum storage being connected with the authenticity of medicament decision-making system 300 that system 200 connects
System 400.
Spectrum data gathering system 200 includes spectrum data gathering portion 1 and communications portion 2.
Spectrum data gathering device 1 gathers the corresponding Raman spectrum of medicine, and generate it is corresponding with the Raman spectrum and
Contain shift value, intensity level, noise figure, response and original with the corresponding maximum range value of spectrum data gathering device 1
Beginning Raman spectrum data.Medicine information and device information are further included in original Raman spectrum data.Original drawing in the present invention
Graceful spectroscopic data is transmitted by txt file.
Communication transmission apparatus 2 is used for the Raman spectrum for obtaining medicine and by the Raman spectrum and opposite with the Raman spectrum
The original Raman spectrum data answered is transferred to authenticity of medicament decision-making system 300.
Standard spectrum storage system 400 includes standard excipients spectrum thesaurus 3, standard active ingredient library of spectra 4, standard light
Compose acquisition device 5 and communicator 6.
Standard excipients spectrum thesaurus 3 is stored with the corresponding standard excipients Raman spectrum of standard pharmaceutical and the standard excipients
Raman spectrum it is corresponding and containing shift value, intensity level, noise figure, response standard excipients spectroscopic data.
Standard active ingredient library of spectra 4 is stored with the corresponding standard active ingredient Raman spectrum of standard pharmaceutical and the standard
Active ingredient Raman spectrum it is corresponding and containing shift value, intensity level, noise figure, response standard active ingredient spectrum number
According to.
Standard spectrum acquisition device 5 obtains corresponding standard excipients Raman spectrum according to medicine to be analyzed and standard is auxiliary
Expect spectroscopic data, corresponding standard active ingredient Raman spectrum and standard active ingredient spectroscopic data.
The standard Raman spectroscopy and the mark that communicator 6 is got standard spectrum acquisition device 5 by communication system
The corresponding standard spectral data of quasi-optical spectrum is sent to authenticity of medicament decision-making system 300.
Fig. 2 is the block diagram of medicine identification system in the embodiment of the present invention.
Judge as shown in Fig. 2, authenticity of medicament decision-making system 300 includes spectrum acquisition device 10, apparatus for temporary storage, spectrum quantity
Device 20, spectral quality detection device 30, spectrum compare decision maker 40 and control unit 50.
Spectrum acquisition device 10 receive the Raman spectrum that spectrum data gathering system 200 sends and with the Raman spectrum
Corresponding original Raman spectrum data, and receive the standard spectral data that standard spectrum storage system 400 is sent.
Apparatus for temporary storage keeps in the Raman spectrum and the corresponding original Raman of the Raman spectrum of the reception of spectrum acquisition device 10
Spectroscopic data and standard spectral data.
Spectrum quantity judgment means 20 include receiving judging part 21 and output section 22.
Receiving judging part 21 includes receiving unit 211, temporary storage location and judging unit 212.
Receiving unit 211 receive the transmission of spectrum acquisition device 10 Raman spectrum and with the corresponding original of the Raman spectrum
Beginning Raman spectrum data, and be temporarily stored in temporary storage location.
Whether judging unit 212 judges the number of the Raman spectrum and original Raman spectrum data received in predetermined number
In the range of amount.It is when judging to receive the Raman spectrum for meeting predetermined quantity scope and original Raman spectrum data, its is temporary
There are in temporary storage location；When judgement receives the Raman spectrum for not meeting predetermined quantity scope and original Raman spectrum data
When, will in temporary storage location the unqualified information of spectrum quantity.In the present embodiment, predetermined quantity scope is 3~30.
Output section 22 is defeated by the Raman spectrum and original Raman spectrum data that meet predetermined quantity scope in temporary storage location
Go out to spectral quality detection device 30；Or the unqualified information of spectrum quantity is exported to spectrum acquisition device 10.
The unqualified information of spectrum quantity is sent to spectrum data gathering system 200 by spectrum acquisition device 10.
Fig. 3 is the block diagram of spectral quality detection device in the embodiment of the present invention.
Sentence as shown in figure 3, spectral quality detection device 30 is obtained including receiving division 31, temporary storage part, pre-value storage part, first
Disconnected portion 32, the first configuration part 33, second obtain judging part 34, the second configuration part the 35, the 3rd obtains judging part 36, the 3rd configuration part
37th, the 4th judging part 38, the 4th configuration part 39, determination unit 38 and control unit 39 are obtained.
Pre-value storage part storage predetermined lower bound value, predetermined upper limit value, predetermined ratio scope, predetermined threshold and predetermined acquisition
Rule.Predetermined lower bound value is 200, predetermined upper limit value 2, and predetermined ratio scope is 2 to 100, predetermined threshold 3000.
Receiving division 31 receives the Raman spectrum of the output of spectrum quantity judgment means 20 and original Raman spectrum data, and will
It is temporarily stored in temporary storage part.
First acquisition judging part 32 includes shift value acquiring unit 321 and first condition judging unit 322.
Shift value acquiring unit 321 obtains original Raman spectrum data from temporary storage part, and obtains the original Raman spectrum
Maximum displacement value and least displacement value in data, and obtain predetermined lower bound value, predetermined upper limit value from pre-value storage part.
First condition judging unit 322 judges whether to meet that least displacement value is less than predetermined lower bound value, and maximum displacement value is big
In the first condition of predetermined upper limit value.
When judging to meet first condition, Raman spectrum is set as the first qualified spectrum by the first configuration part 33, and by the
One qualified spectrum is temporarily stored in temporary storage part；When judging to be unsatisfactory for first condition, the first configuration part 33 does not carry out Raman spectrum
Setting, and Raman spectrum is temporarily stored in temporary storage part.
Fig. 4 is the Raman spectrum for meeting first condition.
As shown in figure 4, Raman spectrum least displacement value is 69cm-1, maximum displacement value 2799cm-1, meet first
Part.So the Raman spectrum can be set as to the first qualified spectrum, and it is temporary to it.
Second, which obtains judging part 34, includes maximum intensity value acquiring unit 341, maximum range value acquiring unit 342 and the
Two condition judgment units 343.
Maximum intensity value acquiring unit 341 obtains original Raman spectrum data from temporary storage part, and obtains the original Raman
Maximum intensity value in spectroscopic data.
Maximum range value acquiring unit 342 obtains original Raman spectrum data from temporary storage part, and obtains the original Raman
The maximum range value of the corresponding instrument of spectroscopic data.
Second condition judging unit 343 judges whether to meet the second condition that maximum intensity value is less than maximum range value.
When judging to meet second condition, Raman spectrum is set as the second qualified spectrum by the second configuration part 35, and by the
Two qualified spectrum are temporarily stored in temporary storage part；When judging to be unsatisfactory for second condition, the second configuration part 35 does not carry out Raman spectrum
Setting, and Raman spectrum is temporarily stored in temporary storage part.
Fig. 5 is a plurality of Raman spectrum for not meeting second condition.
As shown in figure 5, the intensity level of the left end collection of illustrative plates of Raman spectrum exceeds the maximum range value of instrument, can not be to these drawings
Graceful spectrum carries out the analysis of next step, even if analyzing these Raman spectrums, also easily causes to slip up.So the second setting
Portion 35 does not set the Raman spectrum in Fig. 5, and Raman spectrum is temporarily stored in temporary storage part.
3rd, which obtains judging part 36, includes pre-defined rule acquiring unit 361, maximum acquiring unit 362, intensity level acquisition
Unit 363, characteristic peaks identifying unit 364, noise figure acquiring unit 365, ratio calculation unit 366 and third condition judge
Unit 367.
Pre-defined rule acquiring unit 361 obtains corresponding pre-defined rule from pre-value storage part.Making a reservation for acquisition rule is：Work as pole
Intensity level rises while in serial number during intensity level decline in serial number near big value, and setting maximum is characterized peak
Value.Serial number value is 5.
Maximum acquiring unit 362 obtains original Raman spectrum data from temporary storage part, and obtains the original Raman spectrum
Maximum and the corresponding shift value of the maximum in data.
It is corresponding strong to obtain each five shift values in left and right according to the corresponding shift value of maximum for intensity level acquiring unit 363
Angle value.
Characteristic peaks identifying unit 364 judges whether the intensity level that intensity level acquiring unit 363 obtains meets seven, the left side
The intensity level condition that gradually increase and seven, the right intensity level are gradually reduced.When being judged as YES, characteristic peaks identifying unit
364 judge that the maximum is characterized peak value；When being judged as NO, it is not spy that characteristic peaks identifying unit 364, which judges the maximum,
Peak value is levied, maximum acquiring unit 362 obtains maximum again, until finally determining characteristic peaks.
Response noise figure acquiring unit 365 obtains corresponding noise figure and response according to characteristic peaks.
Ratio calculation unit 366 calculates the ratio of response and noise figure.
Third condition judging unit 367 judges whether to meet the ratio of response and noise figure in the range of predetermined ratio
Third condition.
Fig. 6 is the Raman spectrum for meeting third condition.
As shown in fig. 6, with 475cm-1Exemplified by the characteristic peak at place, continuous 5 intensity levels of this feature peak value annex rise, are same
5 intensity levels of Shi Lianxu decline, and the signal-to-noise ratio (ratio of response and noise level) for calculating this characteristic peak is 18, in satisfaction
State area requirement.When judging to meet third condition, Raman spectrum is set as the 3rd qualified spectrum by the 3rd configuration part 37, and will
3rd qualified spectrum is temporarily stored in temporary storage part；When judge be unsatisfactory for third condition when, the 3rd configuration part 37 not to Raman spectrum into
Row setting, and Raman spectrum is temporarily stored in temporary storage part.
When Raman spectrum is set to first condition qualification spectrum, second condition qualification spectrum, third condition qualification spectrum
When, determination unit 38 judges that Raman spectrum is qualified spectrum, and qualified spectrum is temporarily stored in temporary storage part；When the first acquisition judging part
Judgement is unsatisfactory for first condition, the second acquisition judging part judges that being unsatisfactory for second condition or the 3rd acquisition judging part judges not
When meeting Article 3, determination unit 38 judges that Raman spectrum is unqualified spectrum.
Control unit 39, which includes, to be used to control receiving division 31, temporary storage part, pre-value storage part, first to obtain judging part 32, first
Configuration part 33, second obtains judging part 34, the second configuration part the 35, the 3rd obtains judging part 36, the 3rd configuration part 37, determination unit 38
The computer program of operation.
Fig. 7 is the block diagram that spectrum compares decision maker in the embodiment of the present invention.
Include as shown in fig. 7, spectrum compares decision maker 40：It is pre-value storage part, standard excipients spectrum acquisition unit 41, similar
It is worth calculating part 42, similarity value sequence portion 43, auxiliary material information acquiring section 44, contrast judgement portion 45, the first result configuration part 46, factory
Family's spectrum search acquisition unit 47, average similarity value calculating part 48, average similarity value judging part 49, the second result configuration part
410th, medicine spectrum acquisition unit 411, similarity ranking portion 412, threshold decision portion 413, batch spectrum search acquisition unit 414, phase
Like angle value judging part 415, result judgement portion 416 and control unit 417.
Pre-value storage part stores predetermined ranking, predetermined average value ranges and predetermined threshold.Predetermined ranking is 5.Allocate in advance
Average scope is (- 3 times of standard deviations of average value)~(+3 times of standard deviations of average value).In the present embodiment, predetermined threshold is set as
0.95。
Standard excipients spectrum acquisition unit 41 obtains all marks that the transmission of standard excipients spectrum thesaurus comes from apparatus for temporary storage
Quasi- auxiliary material spectrum.
Similar value calculating part 42 calculates the similarity value between qualified spectrum and each standard excipients spectrum respectively.
Fig. 8 is that similar value calculating part calculates similarity value between qualified spectrum and each standard excipients spectrum respectively.
The similarity of each auxiliary material and medicine in Fig. 8 is：0.934 (auxiliary material 1), 0.927 (auxiliary material 2), 0.910 (auxiliary material 4),
0.900 (auxiliary material 4), 0.842 (auxiliary material 5), 0.813 (auxiliary material 6).
The numerical values recited for the similarity value that similarity value sequence portion 43 is calculated according to similar value calculating part 42 is to standard
Auxiliary material spectrum is ranked up, and obtains auxiliary material ranking information.
Auxiliary material information acquiring section 44 obtains predetermined ranking from the auxiliary material ranking information that similarity value sequence portion 43 obtains
Spectrum auxiliary material information, and from qualified spectroscopic data obtain medicine auxiliary material information.
Spectrum auxiliary material information that contrast judgement portion 45 obtains auxiliary material information acquiring section 44 and the same ranking of medicine it is auxiliary
Material information compares one by one, and judges whether consistent.
When judging consistent, the first result configuration part 46 sets medicine as the first qualified medicine；When judging inconsistent, the
One result configuration part 46 sets medicine as unqualified medicine.
Producer's spectrum search acquisition unit 47 is obtained according to the company-information in qualified spectroscopic data from standard pharmaceutical library of spectra
All standard pharmaceutical spectrum of corresponding same producer are taken, and are temporarily stored in temporary storage part.
Similar value calculating part 42 calculates qualified spectrum and the producer's spectrum search that the processing of spectral manipulation device 20 obtains respectively
Similarity value between all standard pharmaceutical spectrum for the same company-information that acquisition unit 47 obtains.In the present invention, use
Pearson correlation coefficient calculates similarity value, and the calculation formula of similarity value is as follows：
Wherein, R is similarity value, XiIt is standard excipients spectrum in the corresponding intensity level of i-th of shift value, YiFor qualified light
For spectrum in the corresponding intensity level of i-th of shift value, n is spectral displacement value.
The similarity value that average similarity value calculating part 48 is obtained according to similarity measure portion 42 calculate qualified spectrum with it is same
Average similarity value between the standard pharmaceutical spectrum of one company-information.Average similarity value calculating part 48 obtains and same producer
After similarity value R between the standard pharmaceutical spectrum of information, sum to similarity value R, then remove in same company-information
Standard pharmaceutical spectrum number n, you can obtain average similarityCalculation formula is as follows：
Wherein, RkFor the similarity value between qualified spectrum and k-th of standard pharmaceutical spectrum.
Whether average similarity value judging part 49 judges average similarity value in predetermined average value ranges.
When being judged as YES, the second result configuration part 410 sets medicine as the second qualified medicine；When being judged as NO, the
Two result configuration parts 410 set medicine as unqualified medicine.
When medicine is set to the first qualified medicine, the second qualified medicine, result judgement portion 416 judges that medicine is true
Medicine；Medicine is not set as the first qualified medicine or the second result configuration part 410 when the first result configuration part 46 does not set medicine
For the second qualified medicine when, result judgement portion 416 judges that medicine is counterfeit drug.
When producer's spectrum search acquisition unit 47 does not retrieve corresponding manufacturer's standard medicine light in standard pharmaceutical library of spectra
Time spectrum, medicine spectrum acquisition unit 411 obtain all standard pharmaceutical spectrum of the different manufacturers of same medicine.
Similarity ranking portion 412 uses Similarity-Weighted voting method, obtains the standard medicine of the similar producer of top ranked
Product spectrum.In the present embodiment, Similarity-Weighted voting method is according to existing qualification medicine factory in standard pharmaceutical library of spectra
The match spectrum number of family carries out similarity ranking.
Similar value calculating part 42 calculates the similarity value between qualified spectrum and the standard pharmaceutical spectrum of similar producer.
Threshold decision portion 413 judges whether similarity value is more than predetermined threshold.
When similarity value is more than predetermined threshold, the second result configuration part 410 sets medicine as the second qualified medicine；Work as phase
When being less than predetermined threshold like angle value, the second result configuration part 410 sets medicine as unqualified medicine.
When getting all standard pharmaceutical spectrum of same producer, to reach more accurately as a result, batch spectrum is searched for
Acquisition unit 414 according to batch information obtained from standard pharmaceutical library of spectra it is corresponding with a batch of standard pharmaceutical spectrum.
Similarity value calculating part 42 calculates qualified spectrum and with the similarity value between a batch of standard pharmaceutical spectrum.
Similarity value judging part 415 judges whether similarity value is more than predetermined threshold.
When judging to be not less than predetermined threshold, the second result configuration part 410 sets medicine as the second qualified medicine；Work as judgement
During less than predetermined threshold, the second result configuration part 410 sets medicine as unqualified medicine.
Control unit 417 include be used for control pre-value storage part, standard excipients spectrum acquisition unit 41, similar value calculating part 42,
Similarity value sequence portion 43, auxiliary material information acquiring section 44, contrast judgement portion 45, the first result configuration part 46, producer's spectrum search
Acquisition unit 47, average similarity value calculating part 48, average similarity value judging part 49, the second result configuration part 410, medicine spectrum
Acquisition unit 411, similarity ranking portion 412, threshold decision portion 413, batch spectrum search acquisition unit 414, similarity value judging part
415 and result judgement portion 416 run computer program.
It is used to control spectrum acquisition device 10, apparatus for temporary storage, spectrum quantity to judge dress as shown in Fig. 2, control unit 40 includes
Put 20, spectral quality detection device 30 and spectrum compares the computer program that decision maker 40 is run.
Fig. 9 is the action flow chart of the authenticity of medicament decision-making system of the embodiment of the present invention.
As shown in figure 9, in the present embodiment, the motion flow of authenticity of medicament decision-making system 300 comprises the following steps：
Step S1, spectrum acquisition device 10 receive the medicine Raman spectrum that spectrum data gathering system 200 is sent
And with the corresponding original Raman spectrum data of the medicine Raman spectrum, subsequently into step S2.
Step S2, spectrum quantity judgment means 20 judge the medicine Raman spectrum received and original medicine Raman spectrum
The number of data, when being judged as YES, enters step S3 whether in the range of predetermined quantity, when being judged as NO, enters step
S5。
Step S3, spectral quality detection device 30 judge whether the medicine Raman spectrum that receives is qualified spectrum, when sentencing
When breaking to be, S4 is entered step, when being judged as NO, enters step S8.
Step S4, spectrum compare decision maker 40 and qualified medicine Raman spectrum and standard Raman spectroscopy are compared,
Obtain to compare and judge as a result, subsequently into step S4.
Step S5, exports the identification result or Spectroscopic analysis results of final medicine, into done state.
Figure 10 is the action flow chart of the spectral quality detection device of the embodiment of the present invention.
As shown in Figure 10, in the present embodiment, the motion flow of spectral quality detection device 30 comprises the following steps：
Step S3-1, receiving division 31 receive the Raman spectrum of the output of spectrum quantity judgment means 20 and original Raman spectrum
Data, and be temporarily stored in temporary storage part, subsequently into step S3-2.
Step S3-2, shift value acquiring unit 321 obtains original Raman spectrum data from temporary storage part, and it is original to obtain this
Maximum displacement value and least displacement value in Raman spectrum data, and obtain predetermined lower bound value, the predetermined upper limit from pre-value storage part
Value, subsequently into step S3-3.
Step S3-3, first condition judging unit 322 judge whether to meet that least displacement value is less than predetermined lower bound value, maximum
Shift value is more than the first condition of predetermined upper limit value, when being judged as YES, enters step S3-4；When being judged as NO, into step
Rapid S3-23.
Raman spectrum is set as the first qualified spectrum by step S3-4, the first configuration part 33, and the first qualified spectrum is temporary
There are in temporary storage part, subsequently into step S3-5.
Step S3-5, maximum intensity value acquiring unit 341 obtains original Raman spectrum data from temporary storage part, and obtains and be somebody's turn to do
Maximum intensity value in original Raman spectrum data, subsequently into step S3-6.
Step S3-6, maximum range value acquiring unit 342 obtains original Raman spectrum data from temporary storage part, and obtains and be somebody's turn to do
The maximum range value of the corresponding instrument of original Raman spectrum data, subsequently into step S3-7.
Step S3-7, second condition judging unit 343 judge whether to meet that maximum intensity value is less than the of maximum range value
Two conditions, when being judged as YES, enter step S3-8；When being judged as NO, S3-23 is entered step.
Raman spectrum is set as the second qualified spectrum by step S3-8, the second configuration part 35, and the second qualified spectrum is temporary
There are in temporary storage part, subsequently into step S3-9.
Step S3-9, pre-defined rule acquiring unit 361 obtains corresponding pre-defined rule from pre-value storage part, subsequently into step
Rapid S3-10.
Step S3-10, maximum acquiring unit 362 obtain original Raman spectrum data from temporary storage part, and obtain the original
Maximum and the corresponding shift value of the maximum in beginning Raman spectrum data, subsequently into step S3-11.
Step S3-11, intensity level acquiring unit 363 obtain each five displacements in left and right according to the corresponding shift value of maximum
It is worth corresponding intensity level, subsequently into step S3-12.
Step S3-12, characteristic peaks identifying unit 364 judge whether the intensity level that intensity level acquiring unit 363 obtains is full
Sufficient seven intensity levels in left side condition that gradually increase and seven, the right intensity level are gradually reduced, when being judged as YES, into step
Rapid S3-13；When being judged as NO, S3-10 is entered step.
Step S3-13, characteristic peaks identifying unit 364 judge that the maximum is characterized peak value, noise figure acquiring unit 365
Corresponding noise figure is obtained according to characteristic peaks, subsequently into step S3-14.
Step S3-14, ratio calculation unit 366 calculates the ratio of characteristic peaks and noise figure, subsequently into step S3-
15。
Step S3-15, the ratio that third condition judging unit 367 judges whether to meet response and noise figure is in predetermined ratio
Third condition in the range of value, when being judged as YES, enters step S3-16；When being judged as NO, S3-23 is entered step.
Raman spectrum is set as the 3rd qualified spectrum by step S3-16, the 3rd configuration part 37, and the 3rd qualified spectrum is temporary
There are in temporary storage part, subsequently into step S3-17.
Step S3-17, determination unit 38 judge whether Raman spectrum is set to first condition qualification spectrum, second condition closes
Lattice spectrum, third condition qualification spectrum, when being judged as YES, enter step S3-18；When being judged as NO, S3- is entered step
19。
Step S3-18, determination unit 38 judges that Raman spectrum is qualified spectrum, subsequently into done state.
Step S3-19, determination unit 38 judges that Raman spectrum is unqualified spectrum, subsequently into done state.
Figure 11 is that the spectrum of the embodiment of the present invention compares the action flow chart of decision maker.
As shown in figure 11, in the present embodiment, the motion flow of spectrum comparison decision maker 40 comprises the following steps：
Step S4-1, standard excipients spectrum acquisition unit 41 obtain the transmission of standard excipients spectrum thesaurus from apparatus for temporary storage and come
All standard excipients spectrum, subsequently into step S4-2.
Step S4-2, similar value calculating part 42 calculate similar between final spectrum and each standard excipients spectrum respectively
Angle value, subsequently into step S4-3.
Step S4-3, the numerical value for the similarity value that similarity value sequence portion 43 is calculated according to similar value calculating part 42 are big
It is small that standard excipients spectrum is ranked up, auxiliary material ranking information is obtained, subsequently into step S4-4.
Step S4-4, auxiliary material information acquiring section 44 obtain in advance from the auxiliary material ranking information that similarity value sequence portion 43 obtains
Secondary spectrum auxiliary material information is named, and the auxiliary material information of medicine is obtained from final spectroscopic data, subsequently into step S4-5.
Step S4-5, spectrum auxiliary material information that contrast judgement portion 45 obtains auxiliary material information acquiring section 44 and medicine it is same
The auxiliary material information of ranking compares one by one, and judges whether unanimously, when judging consistent, to enter step S4-6；It is inconsistent when judging
When, enter step S4-7.
Step S4-6, the first result configuration part 46 sets medicine as the first qualified medicine, subsequently into step S4-8.
Step S4-7, the first result configuration part 46 sets medicine as unqualified medicine, subsequently into step S4-24.
Step S4-8, judges whether the standard pharmaceutical spectrum of same company-information, in the presence of judgement, enters step
S4-9；When judging to be not present, S4-10 is entered step.
Step S4-9, producer spectrum search acquisition unit 47 is according to the company-information in final spectroscopic data from standard pharmaceutical light
All standard pharmaceutical spectrum of corresponding same producer are obtained in spectrum storehouse, subsequently into step S4-11.
Step S4-10, medicine spectrum acquisition unit 411 obtain all standard pharmaceutical light of the different manufacturers of same medicine
Spectrum, subsequently into step S4-17.
Step S4-11, judges whether the standard pharmaceutical spectrum of same batch information, when judging to be not present, enters
Step S4-12；In the presence of judgement, S4-13 is entered step.
Step S4-12, similar value calculating part 42 calculate final spectrum and the factory that the processing of spectral manipulation device 20 obtains respectively
Similarity value between all standard pharmaceutical spectrum for the same company-information that family's spectrum search acquisition unit 47 obtains, subsequently into
Step S4-10.
Step S4-13, similarity value calculating part 42 calculate final spectrum and between a batch of standard pharmaceutical spectrum
Similarity value, subsequently into step S4-20.
Step S4-14, the similarity value that average similarity value calculating part 48 is obtained according to similarity measure portion 42 calculate most
Average similarity value between whole spectrum and the standard pharmaceutical spectrum of same company-information, subsequently into step S4-15.
Step S4-15, average similarity value judging part 49 judge average similarity value whether in predetermined average value ranges,
Subsequently into step S4-16.
Whether step S4-16, the result judged are positive result, when being judged as YES, enter step S4-22；When
When being judged as NO, S4-7 is entered step.
Step S4-17, similarity ranking portion 417 use Similarity-Weighted voting method, obtain the similar factory of top ranked
The standard pharmaceutical spectrum of family, subsequently into step S4-18.
Step S4-18, similar value calculating part 42 calculate the phase between final spectrum and the standard pharmaceutical spectrum of similar producer
Like angle value, subsequently into step S4-19.
Step S4-19, threshold decision portion 413 judge whether similarity value is more than predetermined threshold, subsequently into step S4-
16。
Step S4-20, similarity value calculating part 42 calculate final spectrum and between a batch of standard pharmaceutical spectrum
Similarity value, subsequently into step S4-21.
Step S4-21, similarity value judging part 415 judge whether similarity value is more than predetermined threshold, subsequently into step
S4-16。
Step S4-22, the second result configuration part 410 sets medicine as the second qualified medicine, subsequently into step S4-24.
Step S4-23, result judgement portion 416 judge whether medicine is set to the first qualified medicine, the second qualified medicine,
When being judged as YES, S4-24 is entered step；When being judged as NO, S4-25 is entered step.
Step S4-24, result judgement portion 416 judges that medicine is true medicine, subsequently into step S5.
Step S4-25, result judgement portion 416 judges that medicine is counterfeit drug, subsequently into step S5.
Step S5, exports as a result, subsequently into done state.
The authenticity of medicament decision-making system of the present embodiment is suitable for but is not limited to Raman spectrum, infrared spectrum, near red
The quality control of external spectrum.At the same time the present invention authenticity of medicament decision-making system, except with spectrum data gathering device and standard
Spectrum storage system connects, can also be with spectrum data gathering system and sheet outside the medicine spectrum true and false for judging medicine
The standard spectrum storage system connection on ground uses.
The effect of embodiment
Authenticity of medicament decision-making system according to involved by the present embodiment, because having spectral quality detection device and spectrum
Decision maker is compared, so on the one hand the authenticity of medicament decision-making system of the present embodiment can pass through spectral region, maximum range value, light
Spectrum signal-to-noise ratio, spectral intensity etc. are controlled spectral quality, to ensure that the spectral quality of sample meets subsequent analysis
It is required that while also the experiment parameter in sample collector's practical operation is set give and instruct so that greatly improve work efficiency and
The accuracy of subsequent analysis result；On the other hand, in spectrum compares decision maker, standard excipients spectrum acquisition unit, similar value
Calculating part, similarity value sequence portion, auxiliary material information acquiring section, contrast judgement portion and the first result configuration part form first and judge
Mode, producer's spectrum search acquisition unit, average similarity value calculating part, average similarity value judging part and the setting of the second result
Portion forms the second judgment mode, so, the authenticity of medicament decision-making system of the present embodiment is by the first judgment mode from auxiliary material information
The level analysis constituent of medicine, according to matched auxiliary material result can verify auxiliary material and its component explanation it is whether consistent come
Judge authenticity of medicament, while in terms of medicine spectrum dissect by the second judgment mode and judge medicine, so to medicine into
The true and false judgement of row；In addition, two kinds of judgment modes are separate, it does not interfere with each other, can be to avoid error caused by extraneous factor, into one
Step improves the accuracy of result judgement.
In addition, the authenticity of medicament decision-making system of the present embodiment is truly realized simplification, intelligence, networking, high efficiency
Etc. function, it is not high to the technical requirements of operating personnel and can in time feedback operation personnel the problem of where, from time, place
Limitation, efficiently realize that information, data and classical analysis scheme are shared.
The above embodiment is the preferred case of the present invention, is not intended to limit protection scope of the present invention.
In the present embodiment, first judging part 32, the first configuration part 33 the first processing mode of composition are obtained, the second acquisition is sentenced
Disconnected portion 34, the second configuration part 35 form second processing mode, and the 3rd obtains judging part 36, the 3rd configuration part 37 forms the 3rd processing
Mode.For the Quality estimation of Raman spectrum, sequentially transported according to the first processing mode, second processing mode and the 3rd processing mode
OK, and as the spectral quality detection device of the present invention, second processing mode can also be used, at the first processing mode and the 3rd
Reason mode is sequentially run or other aligning methods carry out Quality estimation to Raman spectrum.
In the present embodiment, standard excipients spectrum acquisition unit 31, similar value calculating part 32, similarity value sequence portion 33, auxiliary
Material information acquiring section 34, contrast judgement portion 35, the first result configuration part 36 the first judgment mode of composition, similar value calculating part 32,
Producer's spectrum search acquisition unit 37, average similarity value calculating part 38, average similarity value judging part 39, the second result configuration part
310th, medicine spectrum acquisition unit 311, similarity ranking portion 312, threshold decision portion 313, batch spectrum search acquisition unit 314, phase
The second judgment mode is formed like angle value judging part 315.In the present embodiment, for the Quality estimation of Raman spectrum, according to first
Judgment mode, the second judgment mode are sequentially run, but compare decision maker as the spectrum of the present invention, can also be sentenced using second
Disconnected mode, the first judgment mode, which are sequentially run, to be carried out Quality estimation to Raman spectrum or is transported side by side using two kinds of judgment modes
OK.
Claims (8)
1. a kind of authenticity of medicament decision-making system, is connected with spectrum data gathering system and standard spectrum storage system, for sentencing
The true and false of the fixed medicine, it is characterised in that including：
Spectrum acquisition device, for receive medicine spectrum that the spectrum data gathering system sends and with the medicine spectrum
It is corresponding and at least containing shift value, intensity level, noise figure, auxiliary material information, company-information, batch information and with the spectrum
The original spectral data of the corresponding maximum range value of data collecting system, and receive the standard spectrum storage system and send
Standard pharmaceutical spectrum and with the corresponding standard spectral data of standard pharmaceutical spectrum；
Whether spectrum quantity judgment means, judge the number for the medicine spectrum that the spectrum acquisition device receives predetermined
In quantitative range；
When judging in the range of predetermined quantity, spectral quality detection device carries out the medicine spectrum quality testing, and will close
The medicine spectrum of lattice is determined as qualified spectrum；
Spectrum compares decision maker, for the qualified spectrum to be compared with the standard pharmaceutical spectrum, judges the medicine
The true and false of product,
Wherein, the spectral quality detection device includes：
Receiving division, receives the medicine spectrum and the original spectral data；
First obtains judging part, maximum displacement value and least displacement value is obtained from the original spectral data, and judge whether
Meet that the least displacement value is less than predetermined lower bound value, the maximum displacement value is more than the first condition of predetermined upper limit value；
First configuration part, when judging to meet the first condition, sets the medicine spectrum as first condition qualification spectrum；
Second obtains judging part, maximum intensity value is obtained from the original spectral data, and judge whether to meet the maximum
Intensity level is less than the second condition of the maximum range value；
Second configuration part, when judging to meet the second condition, sets the medicine spectrum as second condition qualification spectrum；
3rd obtains judging part, and predetermined number is obtained from the intensity level of the original spectral data according to the predetermined rule that obtains
The maximum of amount, and using the maximum as characteristic peaks, at the same obtain with the corresponding noise figure of this feature peak value, and judge
Whether the ratio of the characteristic peaks and noise figure third condition predetermined ratio in the range of is met；
3rd configuration part, when judging to meet the third condition, sets the medicine spectrum as third condition qualification spectrum；With
And
Determination unit, is closed when the medicine spectrum is set to first condition qualification spectrum, second condition qualification spectrum, third condition
During lattice spectrum, judge the medicine spectrum for qualified spectrum.
2. authenticity of medicament decision-making system according to claim 1, it is characterised in that：
Wherein, the spectrum compares decision maker and includes：
Standard excipients spectrum acquisition unit, obtains all standard excipients light that the standard excipients spectrum thesaurus transmission comes
Spectrum；
Similar value calculating part, calculates the similarity value between the qualified spectrum and each described standard excipients spectrum respectively；
Similarity value sequence portion, is ranked up the standard excipients spectrum according to the size of the similarity value, obtains auxiliary material
Ranking information；
Auxiliary material information acquiring section, obtains the spectrum auxiliary material information of predetermined ranking from the auxiliary material ranking information, and from the conjunction
The auxiliary material information of the medicine is obtained in lattice spectroscopic data；
Contrast judgement portion, the auxiliary material information of the spectrum auxiliary material information and the same ranking of the medicine is compared one by one, and is sentenced
It is disconnected whether consistent；
First result configuration part, when judging consistent, sets the medicine as the first qualified medicine；
Producer's spectrum search acquisition unit, corresponding same factory is obtained according to the company-information from the standard pharmaceutical library of spectra
All standard pharmaceutical spectrum of family,
The similar value calculating part calculates all standard pharmaceutical spectrum of the final spectrum and same company-information respectively
Between similarity value,
Average similarity value calculating part, calculate the final spectrum and the same company-information the standard pharmaceutical spectrum it
Between average similarity value,
Average similarity value judging part, judges average similarity value whether in predetermined average value ranges,
Second result configuration part, when being judged as YES, sets the medicine as the second qualified medicine,
Result judgement portion, when the medicine is set to the first qualified medicine, the second qualified medicine, it is true to judge the medicine
Medicine.
3. authenticity of medicament decision-making system according to claim 1, it is characterised in that：
Wherein, when the described first acquisition judging part judges to be unsatisfactory for the first condition, the second acquisition judging part judgement not
When meeting that the second condition or the 3rd acquisition judging part judge to be unsatisfactory for the third condition, the determination unit is sentenced
The fixed medicine spectrum is unqualified spectrum,
The judgement result of the determination unit is sent to the spectrum data gathering system by the spectrum acquisition device.
4. authenticity of medicament decision-making system according to claim 1, it is characterised in that：
Wherein, when the spectrum quantity judgment means judge the number of the medicine spectrum not in the range of predetermined quantity, institute
State spectral quality detection device and quality testing do not carried out to the original spectral data,
The judging result of the spectrum quantity judgment means is sent to the spectrum data gathering system by the spectrum acquisition device
System.
5. authenticity of medicament decision-making system according to claim 1, it is characterised in that：
Wherein, the predetermined lower bound value is any one value in 150 to 250,
The predetermined upper limit value is any one value in 2500~2700,
The predetermined ratio scope is 2 to 100,
Between the predetermined threshold is 2000 to 10000 and be 100 integral multiple arbitrary value.
6. authenticity of medicament decision-making system according to claim 1, it is characterised in that：
Wherein, the predetermined ranking is any one numerical value in 3~6,
The predetermined number is any one numerical value in 5~20,
The predetermined rule that obtains is centered on the maximum, when described strong in the serial number on the left side of the maximum
When angle value rises while the intensity level declines in the serial number on the right, set the maximum and be characterized peak value, the company
Continuous numerical value is any one numerical value in 4~9.
7. authenticity of medicament decision-making system according to claim 1, it is characterised in that：
Wherein, when the first result configuration part does not set the medicine as the first qualified medicine or second result setting
When portion does not set the medicine as the second qualified medicine, the result judgement portion judges that the medicine is counterfeit drug.
A kind of 8. authenticity of medicament decision method, it is characterised in that：
Receive the medicine spectrum that sends of spectrum data gathering system and with the corresponding original spectral data of medicine spectrum,
And receive standard pharmaceutical spectrum that the standard spectrum storage system sends and with the corresponding mark of standard pharmaceutical spectrum
Quasi-optical modal data；
Judge the number for the medicine spectrum that the spectrum acquisition device receives whether in the range of predetermined quantity；
When judging in the range of predetermined quantity, the medicine spectrum and the original spectral data are received；
Maximum displacement value and least displacement value are obtained from the original spectral data, and judges whether to meet the least displacement
Value is less than predetermined lower bound value, and the maximum displacement value is more than the first condition of predetermined upper limit value；
When judging to meet the first condition, the medicine spectrum is set as first condition qualification spectrum；
Maximum intensity value is obtained from the original spectral data, and judges whether to meet the maximum intensity value less than described in most
The second condition of wide range value；
When judging to meet the second condition, the medicine spectrum is set as second condition qualification spectrum；
According to the predetermined maximum for obtaining rule and predetermined quantity being obtained from the intensity level of the original spectral data, and by the pole
Big value is used as characteristic peaks, while acquisition and the corresponding noise figure of this feature peak value, and judges whether to meet the characteristic peak
Third condition of the ratio of value and the noise figure in the range of predetermined ratio；
When judging to meet the third condition, the medicine spectrum is set as third condition qualification spectrum；And
When the medicine spectrum is set to first condition qualification spectrum, second condition qualification spectrum, third condition qualification spectrum
When, the medicine spectrum is judged for qualified spectrum,
Obtain all standard excipients spectrum that the transmission of standard excipients spectrum thesaurus comes；
The similarity value between the qualified spectrum and each described standard excipients spectrum is calculated respectively；
The standard excipients spectrum is ranked up according to the size of the similarity value, obtains auxiliary material ranking information；
The spectrum auxiliary material information of predetermined ranking is obtained from the auxiliary material ranking information, and is obtained from the qualified spectroscopic data
The auxiliary material information of the medicine；
The auxiliary material information of the spectrum auxiliary material information and the same ranking of the medicine is compared one by one, and is judged whether consistent；
When judging consistent, the medicine is set as the first qualified medicine；
Searched for according to the active ingredient information from the standard active ingredient spectrum thesaurus and obtain corresponding standard activity
Composition spectrum；
The maximum of predetermined quantity is obtained from the intensity level according to the predetermined rule that obtains, and the peak where the maximum is set
It is set to characteristic peak；
Calculate the characteristic peak and the standard activity of the predetermined number of the qualification spectrum in the range of same shift value into
The matching value of the characteristic peak of spectral；
Judge whether the matching value is qualified；
When judging qualified, the medicine is set as the second qualified medicine；
When the medicine is set to the first qualified medicine, the second qualified medicine, it is true medicine to judge the medicine.
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