CN107982584A - A kind of medical degradable zinc bismuth lithium system alloy - Google Patents
A kind of medical degradable zinc bismuth lithium system alloy Download PDFInfo
- Publication number
- CN107982584A CN107982584A CN201711263437.4A CN201711263437A CN107982584A CN 107982584 A CN107982584 A CN 107982584A CN 201711263437 A CN201711263437 A CN 201711263437A CN 107982584 A CN107982584 A CN 107982584A
- Authority
- CN
- China
- Prior art keywords
- mass percent
- alloy
- lithium system
- zinc bismuth
- system alloy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The present invention relates to a kind of medical degradable zinc bismuth lithium system alloy, zinc bismuth lithium system alloy is made of Zn, Bi and Li, by percentage to the quality, the mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, and the mass percent of the element Li is 0 ＜ Li≤10%.Zinc bismuth lithium system alloy can also be made of Zn, Bi, Li and element X, the element X is at least one of Sr, Ca, Mn, Si, Ag, Mg, Cu, Sn, Ge element, by percentage to the quality, the mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, the mass percent content of the element Li is 0 ＜ Li≤10%, and the mass percent content of the element X is 0 ＜ X≤10%.The medical degradable zinc bismuth lithium system alloy, it is safe and non-toxic, and excellent in mechanical performance, degradation speed are moderate.
Description
Technical field
The invention belongs to biomaterial for medical purpose field, more particularly to a kind of medical degradable zinc bismuth lithium system alloy.
Background technology
Medical metal has excellent mechanical property, frequently as the first choice of implantation material, the nondegradable metal of implantation
As non-self organization material, the life in the future to patient adversely affects material.For example, often used in micro-wound surgical operation
Anastomosis staple coincide tissue cut (or port), the patient of mucous membranes on haemorrhoids circular resection operation is lived through, since anus is attached
The presence of nearly metal anastomotic nail, can stimulate patient to produce more defecation desires；The patient of fracture fixing operation is lived through, implantation
Nail, hone lamella generally require secondary taking-up, allow patient to undergo the risk that operation is grieved and infects again, while add patient's warp
Ji burden and psychological burden；Patient for implanting angiocarpy bracket, the stent of its internal implantation, which exists, triggers blood vessel again
Secondary narrow risk.With the development and progress of medicine, while more doctors are desirable in healing patient disease, subtract as far as possible
Few body burden and psychological burden caused by it.For this reason, develop degradable metal implant material as material scholar and
The common long-cherished wish of doctor.
Degradable metal research is based on magnesium-based in the world at present, although magnesium base degradable metal is achieved in field of orthopaedics
Compared with much progress, but limitation is also suffered from minimally invasive surgery and Internal Medicine-Cardiovascular Dept. field, its basic reason is the modeling of magnesium-base metal
The poor and degradation speed of property is too fast.Zinc-base degradation material is due to excellent mechanical property and degradation speed, being increasingly becoming
The emphasis of medical field concern.Zinc is six big enzyme of human body, the composition or coenzyme of 200 kinds of metalloenzyme, general metabolism is risen wide
General effect, can promote the normal development and regeneration of skin, bone and sexual organ, and can also play promotion to the sense of taste and appetite makees
With.Zinc can also activate ALP and promote the deposition of poroma calcium salt, therefore appropriate zinc supplementation contributes to cell proliferation and differentiation and related enzyme system
System plays its functional activity, accelerates the formation and calcification of bone, so as to promote union, and zinc-deficiency can hinder cartilage generation and
Normal calcification process.Zinc-containing alloy has moderate a degradation speed and plasticity, and catabolite neither produce gas again will not body
Product expansion, is a kind of new degradable metal material.But the low strength of pure zinc, it is difficult to meet Clinical practice requirement,
In eight degradable metal international conferences, there is unit to disclose the intravascular stent prepared with pure zinc after animal blood vessels are implanted into, by
Stent is caused serious Collapse Deformation occur in pure zinc mechanical property deficiency.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of medical degradable zinc bismuth lithium system alloy, peace
Atoxic, and excellent in mechanical performance, degradation speed are moderate.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of medical degradable zinc bismuth lithium system alloy, it is characterised in that zinc bismuth lithium system's alloy is by Zn, Bi and Li group
Into by percentage to the quality, the mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, the element Li's
Mass percent is 0 ＜ Li≤10%.
In one embodiment, zinc bismuth lithium system alloy is made of Zn, Bi and Li, by percentage to the quality, described
The mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, and the mass percent of the element Li is 0 ＜ Li≤3%.
The purpose of the present invention can also be achieved through the following technical solutions：
A kind of medical degradable zinc bismuth lithium system alloy, it is characterised in that zinc bismuth lithium system alloy is by Zn, Bi, Li and member
Plain X compositions, the element X are at least one of Sr, Ca, Mn, Si, Ag, Mg, Cu, Sn, Ge element, by percentage to the quality,
The mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, and the mass percent content of the element Li is 0 ＜
Li≤10%, the mass percent content of the element X is 0 ＜ X≤10%.
In one embodiment, the sum of mass percent of the element Li and the element X is 0~10%, but not
Including 0.
In one embodiment, the element X is at least one of Sr, Ca, Mn, Si element, with mass percent
Meter, the mass percent content of the element Li is not 0, the quality percentage of element Li and element X in zinc bismuth lithium system alloy
The sum of number is 0~2%, but does not include 0.
In one embodiment, the element X is Ag elements, by percentage to the quality, the quality hundred of the element Bi
Fraction is 0 ＜ Bi≤5%, and the mass percent content of the element Li is not 0, and the mass percent content of the elements A g is not
For 0, the mass percent of the element Li and the elements A g and be 0~2%, but do not include 0.
Compared with the existing technology, the beneficial effects are mainly as follows：
1. bismuth element and elemental lithium are incorporated into medical degradable kirsite system, the medicine of bismuth element by the present invention at the same time first
Having been obtained for widely verifying with acting in medical history, surgery handles wound and hemostasis using the astriction of bismuth medicine,
Bismuth, which can enter, suppresses its growth inside bacterium, have antibacterial action, and bismuth preparation is suppression recognized in the world or kills
One of most effective medicine of helicobacter pylori of going out, therefore be widely used in treating gastrointestinal disease, peptic ulcer etc., bismuth compound is also
It is used to treat syphilis, hypertension, infection and skin disease etc..Elemental lithium be in human body one kind trace element, its presence and
Change can have a huge impact human body.Research shows that lithium has beneficial effect to health, as lithium can improve hematopoiesis work(
Can, improve human immunologic function.Lithium Central nervous activity has adjustment effect, is effective tranquillizer, and energy is calm, calms the nerves, and controls
Neurological disorders processed.Lithium can also substitute sodium, the prevention for angiocardiopathy.Lithium also has protective effect to biomembrane, can increase
The stability of membrane structure.Two kinds of elements introduce medical alloy system at the same time, when can make it that the alloy is degraded, biological property compared with
It is good, improve therapeutic effect.
2. the comprehensive mechanical property of pure zinc is poor, it is impossible to meet clinical medical demand, and bismuth and lithium are as kirsite
In alloying element, improve the intensity of pure zinc, improve the poor comprehensive mechanical property of pure zinc, improve kirsite mechanics
Aspect of performance plays an important role.
3. in fusion process, the addition of bismuth element, improves the mobility and wellability of zinc in kirsite, reduces the damage of zinc
Consumption, for the medical kirsite higher to alloy component requirements, is more conducive to the control of quality and component in fusion process
System, reduces the influence of impurity.
Brief description of the drawings
Fig. 1 and Fig. 2 is plate and rod schematic diagram made of a kind of medical degradable zinc bismuth lithium system alloy of the present invention；
Fig. 3 is tubing made of a kind of medical degradable zinc bismuth lithium system alloy of the present invention；
Fig. 4 is the stent semi-finished product schematic diagram of tubular object extruding shown in Fig. 3 in the present invention；
Embodiment
For the objects, technical solutions and advantages of the present invention are more clearly understood, develop simultaneously embodiment referring to the drawings, right
The present invention is further described.
Experimental method used in following embodiments is conventional method unless otherwise instructed.
The materials, reagents and the like used in the following examples, unless otherwise instructed, can obtain from commercial channels.
Embodiment 1
The present embodiment is related to a kind of medical degradable zinc bismuth lithium system alloy, and zinc bismuth lithium system's alloy is by Zn, Bi and Li group
Into by percentage to the quality, the mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, the element Li's
Mass percent is 0 ＜ Li≤10%.
In a preferred embodiment, it is related to a kind of No. 1 and No. 2 zinc bismuth lithium system alloys, wherein in No. 1 alloy, with
Mass percentage, the content of the element Bi is 10%, and the content of the element Li is 10%, in No. 2 alloys, with matter
Percentage meter is measured, the content of the element Bi is 10%, and the content of the element Li is 3%, by described No. 1 and No. 2 zinc bismuth lithiums
It is after alloy is heat-treated, it is 1cm that wire cutting, which prepares the length of side, and thickness is the thin slice of 1.5mm, and sand paper polishing, acetone cleaning, go
It is dry after ionized water cleaning, alcohol washes, sample is subjected to x ray irradiation x sterilizing thereafter, sample is soaked in 37 DEG C of woodss thereafter
In lattice test solution, liquid was changed every 3 days, after calculating weightlessness, show that the outer corrosion rate of the alloy static body is about 0.1~0.3mm/.
In the series alloy, bismuth element and elemental lithium are introduced at the same time, make use of the pharmacologic action such as bismuth element antibacterial and convergence, and
Elemental lithium can improve hematopoiesis function, improve the effect of human immunologic function etc., can be by adjusting the addition of two kinds of elements respectively
Amount, to reach the effect for adjusting the constituent content discharged of finally degrading.
In a further advantageous embodiment, in the zinc bismuth lithium system alloy element Bi mass percent for 0 ＜ Bi≤
1%, the mass percent of element Li is 0 ＜ Li≤0.75%, and component is shown in Table 1.Alloy melting, Homogenization Treatments, heat treatment,
After surface treatment, preparation becomes mechanical test sample 3~8, and 3~No. 8 sample testing results are as shown in Table 1 below, first
The addition of plain Bi and element Li, it is possible to increase the intensity of kirsite, being improved to the elongation percentage of alloy also has reduction, and list is not presented
To rule.As shown in test result, when element Bi content is 0.5~1%, for the zinc bismuth lithium containing equal volume element Bi
Alloy, with the increase of element Li contents, the intensity and elongation percentage of the alloy are obtained for certain raising, possess preferable
Comprehensive performance.Since the comprehensive mechanical property of pure zinc is poor, it is impossible to meet clinical medical demand, and bismuth and lithium are closed as zinc
Alloying element in gold, improves the intensity of pure zinc, improves the poor comprehensive mechanical property of pure zinc, is improving the power of kirsite
Aspect of performance is learned to play an important role.The zinc bismuth lithium series alloy can be in terms of the medical applications such as angiocarpy, orthopaedics
Embody application advantage.
A kind of medical degradable zinc bismuth lithium system alloy mechanical property test result of the present invention of table 1：
Embodiment 2
The present embodiment is related to a kind of medical degradable zinc bismuth lithium system alloy, and zinc bismuth lithium system alloy is by Zn, Bi, Li and member
Plain X compositions, the element X are at least one of Sr, Ca, Mn, Si, Ag, Mg, Cu, Sn, Ge element, by percentage to the quality,
The mass percent content of the element Bi is 0 ＜ Bi≤10%, the mass percent content of the element Li for 0 ＜ Li≤
The mass percent content of 10, the element X are 0 ＜ X≤10.
In a preferred embodiment, the mass percent content of the element Bi is 10%, the element X for Sr and
The mass percent content summation of Ag, the element Li and the element X are 10%, wherein the mass percent of the elements A g
Content is 0.2%, and the mass percent content of the elements Sr is 0.2%, surplus Li.Element addition in the embodiment,
There is excellent biology performance according to for element Li, elements A g can increase the anti-microbial property of alloy, and elements Sr can anti-tampon shape
Into, promote skeletonization.After above-mentioned alloy is heat-treated, it be 1cm that wire cutting, which prepares the length of side, and thickness is the thin slice of 1.5mm, sand paper
It is dry after polishing, acetone cleaning, deionized water cleaning, alcohol washes, sample is subjected to x ray irradiation x sterilizing thereafter, thereafter will
Sample is soaked in 37 DEG C of ringer's solutions, and liquid was changed every 3 days, after calculating weightlessness, is drawn and is corroded speed outside the series alloy static body
Rate is about 0.06~0.8mm/.
In one embodiment, the mass percent content of the element Bi is 1%, the mass percent of the element Li
Content is 10%, and the element X is Mn, Sr and Mg, and the mass percent content of the element X is 10%, alloy is carried out equal
After homogenizing processing, heat treatment, surface treatment, compression test sample is made, chooses sample and is tested, speed：1mm/min, is surveyed
Test result shows, the equal ＞ 170MPa of compression strength (compact bone is about 160MPa) of sample, meets the application demand of orthopaedics, due to
Described element M n, Sr and Mg are beneficial to the effect of orthopaedics, therefore the serial alloy is suitable for orthopaedics application.
Embodiment 3
The present embodiment is related to a kind of medical degradable zinc bismuth lithium system alloy, is with upper one embodiment difference, institute
Element is stated as at least one of Sr, Ca, Mn, Si element, by percentage to the quality, the mass percent content of the element Li
It is not 0, the sum of mass percent of element Li and element X is 0~2% in zinc bismuth lithium system alloy, but does not include 0.
In a preferred embodiment, it is related to a kind of No. 9 zinc bismuth lithium system alloys, the mass percent content of the element Bi
For 0 ＜ Bi≤0.5%, the mass percent content of the element Li is 0 ＜ Li≤1.5%, and the element X is elements Sr, institute
The mass percent content for stating elements Sr is 0 ＜ Sr≤0.5%, and alloy is carried out Homogenization Treatments, heat treatment, surface treatment
Afterwards, plate as shown in Figure 1 is made and meets compression test, the sample of tension test.Choose test sample to be tested, tension is strong
Equal ＞ 350Mpa are spent, sample is chosen and carries out compression test, speed：1mm/min, test result show that the compression strength of sample is equal
＞ 170MPa (compact bone is about 160MPa), meet the application demand of orthopaedics, and bismuth and lithium change as the alloying element in kirsite
It has been apt to the poor comprehensive mechanical property of pure zinc, and elements Sr can promote skeletonization, therefore the series zinc bismuth lithium strontium sample is suitable for bone
Section applies.
In a preferred embodiment, it is related to a kind of zinc bismuth lithium system alloy, the mass percent content of the element Bi is
The mass percent content of 0.5%, the element Li are 1.8%, and the element X is Elements C a, the quality hundred of the Elements C a
Fractional content is 0 ＜ Ca≤0.2%, after alloy is carried out Homogenization Treatments, heat treatment, surface treatment, is made as shown in Figure 1
Plate and the sample for meeting compression test, tension is tested.Choose test sample to be tested, the equal ＞ 220Mpa of tensile strength, choose
Sample carries out compression test, speed：1mm/min, test result show that (compact bone is about by the equal ＞ 170MPa of compression strength of sample
For 160MPa), meet the application demand of orthopaedics, bismuth and lithium as the alloying element in kirsite, improve poor comprehensive of pure zinc
Mechanical property is closed, and Elements C a can promote skeletonization, therefore the series zinc bismuth lithium calcium sample is suitable for orthopaedics application.
In a further advantageous embodiment, the difference with above-described embodiment is, the quality percentage of the element Bi
Number contents be 0 ＜ Bi≤10%, and the mass percent content of the element Li is 1%, and the element X is element M n, the member
The mass percent content of plain Mn is 0 ＜ Mn≤1%, and anti-bending test, speed 10mm/ are carried out with the zinc bismuth lithium manganese alloy sample
Min, span：96mm, test result show, the equal ＞ 220Mpa of bending strength, much larger than PEEK used in current commercialized product
It is poor to improve pure zinc as the alloying element in kirsite for the bending strength of material (bending strength >=110Mpa), bismuth and lithium
Comprehensive mechanical property, also meet the bending resistance application demand of commercially available spinal fusion device.
Embodiment 4
The present embodiment is related to a kind of medical degradable zinc bismuth lithium system alloy, and zinc bismuth lithium system alloy is by Zn, Bi, Li and member
Plain X compositions, the element X is Ag elements, and by percentage to the quality, the mass percent of the element Bi is 0 ＜ Bi≤5%,
The mass percent content of the element Li is not 0, and the mass percent content of the elements A g is not 0, the element Li and
The sum of mass percent of the elements A g is 0~2%, but does not include 0.
In a preferred embodiment, the mass percent of the element Bi is 5%, the mass percent of the element Li
For 1.8, the mass percent of the elements A g is 0.2%, the zinc bismuth lithium silver alloy sample trombone slide is processed, at the polishing of surface
After reason, bar as shown in Figure 2 is obtained.
In a further advantageous embodiment, it is related to a kind of No. 10 zinc bismuth lithium silver alloy samples, wherein the matter of the element Bi
It is 0.55% to measure relative content, and the mass percent content of the element Li is 0.75%, the quality percentage of the elements A g
Number content is 0.13%, and test obtains No. 19 alloy extrusion states sample tensile strength the ＞ 400Mpa, yield strength ＞
350Mpa, elongation percentage ＞ 20%, the zinc bismuth lithium silver alloy sample trombone slide is processed, after the polishing treatment of surface, is made such as Fig. 3 institutes
The tubing of the outside diameter 1.5mm wall thickness 0.13mm shown, obtained tubing by become after laser cutting stent as shown in Figure 4 half into
Product.The addition of element Bi, Li and Ag, improves the comprehensive mechanical property of the kirsite, meanwhile, element Bi has convergence and sterilization
Function, element Li can improve hematopoiesis function, improve human immunologic function, prevention and cure of cardiovascular disease, and elements A g can increase alloy
Anti-microbial property, certain benefit is embodied in the application aspect of angiocardiopathy.
Finally it should be noted that the foregoing is merely preferred embodiment of the invention, this is not limited to
Invention, all any modification, equivalent and improvement made within the spirit and principles of the invention etc., should be included in this hair
Within bright protection domain.
Claims (6)
- A kind of 1. medical degradable zinc bismuth lithium system alloy, it is characterised in that zinc bismuth lithium system alloy is made of Zn, Bi and Li, By percentage to the quality, the mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, the quality of the element Li Percentage is 0 ＜ Li≤10%.
- 2. medical degradable zinc bismuth lithium system alloy according to claim 1, it is characterised in that zinc bismuth lithium system's alloy by Zn, Bi and Li are formed, and by percentage to the quality, the mass percent of Bi is 0 ＜ Bi≤10% in zinc bismuth lithium system alloy, institute The mass percent for stating element Li is 0 ＜ Li≤3%.
- 3. a kind of medical degradable zinc bismuth lithium system alloy, it is characterised in that zinc bismuth lithium system's alloy is by Zn, Bi, Li and element X Composition, the element X are at least one of Sr, Ca, Mn, Si, Ag, Mg, Cu, Sn, Ge element, by percentage to the quality, institute The mass percent for stating Bi in zinc bismuth lithium system alloy is 0 ＜ Bi≤10%, and the mass percent content of the element Li is 0 ＜ Li The mass percent content of≤10%, the element X are 0 ＜ X≤10%.
- 4. medical degradable zinc bismuth lithium system alloy according to claim 3, it is characterised in that the element Li and the member The sum of mass percent of plain X is 0~10%, but does not include 0.
- 5. medical degradable zinc bismuth lithium system alloy according to claim 3, it is characterised in that the element X for Sr, Ca, At least one of Mn, Si element, by percentage to the quality, the mass percent content of the element Li is not 0, the zinc bismuth The sum of mass percent of element Li and element X is 0~2% in lithium system alloy, but does not include 0.
- 6. medical degradable zinc bismuth lithium system alloy according to claim 3, it is characterised in that the element X is Ag elements, By percentage to the quality, the mass percent of the element Bi is 0 ＜ Bi≤5%, the mass percent content of the element Li It is not 0, the mass percent content of the elements A g is not 0, the mass percent of the element Li and the elements A g and be 0 ~2%, but do not include 0.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711263437.4A CN107982584A (en) | 2017-12-05 | 2017-12-05 | A kind of medical degradable zinc bismuth lithium system alloy |
| CN201811450873.7A CN109536778A (en) | 2017-12-05 | 2018-11-30 | A kind of medical degradable zinc bismuth lithium system alloy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711263437.4A CN107982584A (en) | 2017-12-05 | 2017-12-05 | A kind of medical degradable zinc bismuth lithium system alloy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107982584A true CN107982584A (en) | 2018-05-04 |
Family
ID=62035530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711263437.4A Pending CN107982584A (en) | 2017-12-05 | 2017-12-05 | A kind of medical degradable zinc bismuth lithium system alloy |
| CN201811450873.7A Pending CN109536778A (en) | 2017-12-05 | 2018-11-30 | A kind of medical degradable zinc bismuth lithium system alloy |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811450873.7A Pending CN109536778A (en) | 2017-12-05 | 2018-11-30 | A kind of medical degradable zinc bismuth lithium system alloy |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN107982584A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114182138A (en) * | 2021-12-14 | 2022-03-15 | 西安交通大学 | Biodegradable Zn-Mg-Bi zinc alloy and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3111634B2 (en) * | 1992-05-25 | 2000-11-27 | 松下電器産業株式会社 | Manufacturing method of zinc alkaline battery |
| BE1007443A3 (en) * | 1993-02-25 | 1995-07-04 | Union Miniere Sa | Zinc powder for alkaline batteries. |
| CN106319287A (en) * | 2016-08-25 | 2017-01-11 | 上海交通大学 | Biodegradable medical Zn-Li-X series alloy material and preparation method and application |
-
2017
- 2017-12-05 CN CN201711263437.4A patent/CN107982584A/en active Pending
-
2018
- 2018-11-30 CN CN201811450873.7A patent/CN109536778A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114182138A (en) * | 2021-12-14 | 2022-03-15 | 西安交通大学 | Biodegradable Zn-Mg-Bi zinc alloy and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109536778A (en) | 2019-03-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201617885U (en) | Absorbable magnesium alloy staple used for anastomat | |
| CN107630151B (en) | A kind of beta titanium alloy with antibacterial and promotion knitting function | |
| US11696976B2 (en) | Degradable magnesium-based implant devices for bone fixation | |
| CN106890356A (en) | A kind of degradable zinc-containing alloy implantation material and preparation method and application | |
| CN103463681B (en) | Method for preparing biodegradable magnesium alloy surface modification fluoridated hydroxyapatite coating | |
| CN108277386A (en) | A kind of Zn-Li-Mg systems kirsite and the preparation method and application thereof | |
| DE10163106A1 (en) | Medical implants, prostheses, prosthesis parts, medical instruments, devices and aids made of a halide-modified magnesium material | |
| WO2015096271A1 (en) | High strength and toughness corrosion-resistant zinc alloy inplant material capable of being absorbed by human body | |
| CN106702212A (en) | Medical degradable Zn-Cu-X alloy material and preparation method thereof | |
| CN108315583B (en) | Zn-Li-Mn zinc alloy and preparation method and application thereof | |
| CN101392344A (en) | Degradable Mg-Mn-Zn-Ca mulit-element magnesium alloy material in organism | |
| CN101921929B (en) | Medicinal oxygen-containing beta titanium alloy for orthopedic implantation and preparation method thereof | |
| CN104099501B (en) | A kind of Margarita powder/magnesium alloy quasi natural bone composite and preparation method thereof | |
| CN107653410A (en) | Magnesium alloy that biological medical degradable absorbs and its preparation method and application | |
| CN109266909A (en) | A kind of medical degradable zinc bismuth system alloy | |
| CN106854724A (en) | A kind of medical magnesium alloy materials containing rare earth element and preparation method thereof | |
| CN106399803A (en) | Preparation method of corrosion-resistant biomedical magnesium alloy | |
| CN107982584A (en) | A kind of medical degradable zinc bismuth lithium system alloy | |
| Qu et al. | Evaluation of a new Mg–Zn–Ca–Y alloy for biomedical application | |
| CN109811265A (en) | A kind of Fe-Mn-Cu-C system alloy and its medical application | |
| RU2465015C1 (en) | Oxide coating on transosseous orthopaedic implants made from stainless steel | |
| CN104645422B (en) | A kind of biodegradable magnesium alloy with strong antibacterial functions | |
| CN110106413B (en) | Mg-Si-Ca-Zn magnesium alloy and preparation method and application thereof | |
| Fekry | Electrochemical corrosion behavior of magnesium alloys in biological solutions | |
| CN114182121B (en) | Preparation method of orthopedic fixing material of degradable metal molybdenum-base alloy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180504 |