CN107982441A - 一种治疗头痛的丸剂药物及其制备方法 - Google Patents
一种治疗头痛的丸剂药物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗头痛的认识机理而提供一种治疗头痛的丸剂药物,所述药物的各个组分及其质量份比如下:徐长卿30~150g、菊花50~100g、蔓荆子50~120g、栀子60~120g、白芷30~120g、麦冬100~250g、独活30~100g、沙棘30~100g、羌活100~260g、龙胆草30~70g、生地黄100~350g、防风50~120g、酒黄芩30~100g、细辛10~35g、罗勒50~160g、红花50~120g、柴胡30~120g、天麻30~120g、半夏30~90g、黄芪90~350g、葛根90~160g、川芎50~100g、山楂30~120g、枳实30~120g、石决明90~160g、苍耳子30~100g、藁本30~100g、酒大黄40~100g、延胡索30~120g、木瓜600~1000g、僵蚕50~100g等;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗头痛的丸剂药物,特别是供头痛患者使用的丸剂药物及其制备方法的领域。
背景技术
医者认为:头痛(headache) 是临床常见的症状,通常将局限于头颅上半部,包括眉弓、耳轮上缘和枕外隆突连线以上部位的疼痛统称头痛。头痛病因繁多,神经痛、颅内感染、颅内占位病变、脑血管疾病、颅外头面部疾病、以及全身疾病如急性感染、中毒等均可导致头痛。发病年龄常见于青年、中年和老年。
临床表现:
头痛程度有轻有重,疼痛时间有长有短。疼痛形式多种多样,常见胀痛、闷痛、撕裂样痛、电击样疼痛、针刺样痛,部分伴有血管搏动感及头部紧箍感,以及恶心、呕吐、头晕等症状。继发性头痛还可伴有其他系统性疾病症状或体征,如感染性疾病常伴有发热,血管病变常伴偏瘫、失语等神经功能缺损症状等。头痛依据程度产生不同危害,病情严重可使患者丧失生活和工作能力。
那么,就如何找到一种可有效治疗头痛的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗头痛上,人们逐渐意识到了中医治疗头痛的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗头痛的现状,本发明的目的是在于提供一种治疗头痛的丸剂药物,以解决头痛患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述头痛一证。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗头痛的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
徐长卿30~150g、菊花50~100g、蔓荆子50~120g、栀子60~120g、白芷30~120g、麦冬100~250g、独活30~100g、沙棘30~100g、羌活100~260g、龙胆草30~70g、生地黄100~350g、防风50~120g、酒黄芩30~100g、细辛10~35g、罗勒50~160g、红花50~120g、柴胡30~120g、 天麻30~120g、半夏30~90g、黄芪90~350g、葛根90~160g、川芎50~100g、山楂30~120g、枳实30~120g、石决明90~160g、苍耳子30~100g、藁本30~100g、酒大黄40~100g、延胡索30~120g、木瓜600~1000g、僵蚕50~100g、白芍50~150g、荆芥80~160g、白芥子30~70g、生石膏150~750g、羌活100~260g、人参25~160g、蝉蜕50~120g、全蝎20~70g、甘草30~150g,辅料:淀粉适量。
一种治疗头痛的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
徐长卿38~130g、菊花58~90g、蔓荆子58~105g、栀子70~105g、白芷38~105g、麦冬115~220g、独活38~90g、沙棘38~90g、羌活115~230g、龙胆草38~60g、生地黄115~310g、防风58~105g、酒黄芩38~90g、细辛12~31g、罗勒58~140g、红花58~105g、柴胡38~105g、 天麻38~105g、半夏38~80g、黄芪100~310g、葛根100~140g、川芎58~90g、山楂38~105g、枳实38~105g、石决明100~140g、苍耳子38~90g、藁本38~90g、酒大黄48~90g、延胡索38~105g、木瓜700~850g、僵蚕58~90g、白芍58~130g、荆芥90~140g、白芥子38~60g、生石膏180~660g、羌活115~230g、人参30~140g、蝉蜕58~105g、全蝎26~60g、甘草38~130g,辅料:淀粉适量。
一种治疗头痛的丸剂药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
徐长卿115g、菊花80g、蔓荆子95g、栀子95g、白芷95g、麦冬200g、独活80g、沙棘80g、羌活200g、龙胆草52g、生地黄260g、防风95g、酒黄芩80g、细辛26g、罗勒120g、红花95g、柴胡95g、 天麻95g、半夏70g、黄芪280g、葛根120g、川芎80g、山楂95g、枳实95g、石决明120g、苍耳子80g、藁本80g、酒大黄80g、延胡索95g、木瓜730g、僵蚕80g、白芍118g、荆芥120g、白芥子52g、生石膏580g、羌活200g、人参120g、蝉蜕95g、全蝎52g、甘草115g,辅料:淀粉适量。
一种治疗头痛的丸剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、除淀粉外,将上述原料中药拣去杂质、粉尘及干燥后,按照质量份比共研为极细末待用;
B、按照传统制备中药水丸剂的方法,将研磨好的极细末药物和淀粉过筛后,放入药器中混合拌均,然后制备成水丸剂(其水丸的粒度为:3.9mm~4.0mm),进而烘干,分装密封即得。
一种治疗头痛的丸剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的水丸剂药物以每日三次服用,早中晚各服一次,给药量7g /次,饭后半小时温开水送服。30天为一个疗程,服药1~2个疗程后,症状消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
徐长卿,性味:辛、温,具有祛风化湿、止痛止痒之功效,用于治疗风湿痹痛、胃痛胀满、牙痛、腰痛、跌扑损伤、荨麻疹、湿疹等症
菊花,性味:甘、苦、微寒,具有散风清热、平肝明目之功效,用于治疗风热感冒、头痛眩晕、目赤肿痛、眼目昏花;
蔓荆子,性味:味辛、苦、性微寒,具有疏散风热、清利头目、除湿处关节之功效,用于治疗外感头痛、偏正头风、昏晕目暗、赤眼多泪、目睛内痛、齿龈肿痛、湿痹拘挛;
栀子,性味:苦、寒,具有泻火除烦、清热利湿、凉血解毒,外用消肿止痛之功效,用于防治热病心烦、湿热黄疸、淋证涩痛、血热吐衄、目赤肿痛、火毒疮疡,外治扭挫伤痛;
白芷,性味:味辛、性温,具有祛风除湿、通窃止痛、消肿排脓之功效,用于治疗感冒头痛、眉棱骨痛、牙痛、鼻塞、鼻渊、湿胜久泻、妇女白带、痈疽疮疡、毒蛇咬伤;
麦冬,性味:甘、微苦、微寒,具有养阴生津、润肺清心之功效,用于治疗肺燥干咳、虚痨咳嗽、津伤口渴、心烦失眠、内热消渴、肠燥便秘、咽白喉;
独活,性味:辛、苦、微温,具有祛风除湿、通痹止痛之功效,用于治疗风寒湿痹、腰膝疼痛、少阴伏风头痛;
沙棘,性味:酸、涩、温,具有止咳祛痰、消食化滞、活血散瘀之功效,用于治疗咳嗽痰多、消化不良、食积腹痛、瘀血经闭、跌扑瘀肿;
羌活,性味:辛苦、温,具有散表寒、祛风湿、利关节之功效,用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒;
龙胆草,性味:味苦、性寒,具有清热燥湿、泻肝胆火之功效,用于治疗清热燥湿、泻肝胆火,还用于湿热黄疸、阴肿阴痒、带下、湿疹瘙痒、肝火目赤、耳鸣耳聋、胁痛口苦、强中、惊风抽搐;
生地黄,性味:味甘、苦、性寒,具有清热、凉血之功效,用于治疗温热病热入营血、壮热神昏、口干舌绛;
防风,性味:味辛、甘、性微温,具有祛风解表、胜湿止痛、止痉定搐之功效,用于治疗外感表证、风疹瘙痒、风湿痹痛、破伤风等症;
酒黄芩,性味:苦、寒,具有清热燥湿、泻火解毒、止血、安胎之功效,用于治疗湿温、暑温胸闷呕恶、湿热痞满、泻痢、黄疸、肺热咳嗽、高热烦渴、血热吐衄、痈肿疮毒、胎动不安;
细辛,性味:辛、温,具有祛风散寒、通窍止痛、温肺化饮之功效,用于治疗风寒感冒、头痛、牙痛、鼻塞鼻渊、风湿痹痛、痰饮喘咳;
罗勒,性味:味辛、甘、性温,具有疏风解表、化湿和中、行气活血、解毒消肿之功效,用于治疗感冒头痛、发热咳嗽、中暑、食积不化、不思饮食、脘腹胀满疼痛、呕吐泻痢、风湿痹痛、遗精、月经不调、牙痛口臭、胬肉遮睛、皮肤湿疮、瘾疹瘙痒、跌打损伤、蛇虫咬伤;
红花,性味:味辛、性温,具有活血能经、祛瘀止痛之功效,用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症;
柴胡,性味:味苦、辛、性微寒,具有解表退热、疏肝解郁、升举阳气之功效,用于治疗外感发热、寒热往来、疟疾、肝郁胁痛乳胀、头痛头眩、月经不调、气虚下陷之脱肛、子宫脱垂、胃下垂等症;
天麻,性味:甘、辛、平,无毒,具有息风止痉、平肝阳、祛风通络之功效,用于治疗急慢惊风、抽搐拘挛、眩晕、头痛、半身不遂、肢麻、风湿痹痛;
半夏,性味:辛、温,有毒,具有燥湿化痰、降逆止呕、消痞散结之功效,用于治疗痰多咳喘、痰饮眩悸、风痰眩晕、痰厥头痛、呕吐反胃、胸脘痞闷、梅核气,生用外治痈肿痰核,姜半夏多用于降逆止呕;
黄芪,性味:甘、温,具有补气固表、利尿消肿、托毒排脓、敛疮生肌、生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴,慢性肾炎蛋白尿、糖尿病;
葛根,性味:味甘、辛、性凉,具有解肌退热、透疹、生津止渴、升阳止泻之功效,用于治疗表证发热、项背强痛、麻疹不透、热病口渴、阴虚消渴、热泻热痢、脾虚泄泻;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛;
山楂,性味:酸甘、微温,无毒,具有消食积、化滞瘀之功效,用于治疗饮食积滞、脘腹胀痛、泄泻痢疾、血瘀痛经、闭经、产后腹痛、恶露不尽等症;
枳实,性味:苦、辛、酸、微寒,具有破气消积、化痰散痞之功效,用于治疗积滞内停、痞满胀痛、泻痢后重、大便不通、痰滞气阻、胸痹、结胸、脏器下垂;
石决明,性味:味甘、苦、性寒、微咸,具有清肝明目、润肠通便之功效,用于治疗目赤涩痛、羞明多泪、头痛眩晕、目暗不明、大便秘结;
苍耳子,性味:味苦、甘、辛、性温,小毒,具有散风寒、通鼻窍、祛风湿、止痒之功效,用于治疗鼻渊、风寒头痛、风湿痹痛、风疹、湿疹、疥癣等症;
藁本,性味:味辛、性温,具有祛风散寒、除湿止痛之功效,用于治疗风寒表证、巅顶疼痛、风湿痹痛;
酒大黄,性味:味苦、性寒,具有清上焦血分热毒之功效,用于治疗目赤咽肿、齿龈肿痛;
延胡索,性味:辛、苦、温,具有活血、行气、止痛之功效,用于治疗胸胁、脘腹疼痛、胸痹心痛、经闭痛经、产后瘀阻、跌扑肿痛等症;
木瓜,性味:酸、温,具有平肝舒筋、和胃化湿之功效,用于治疗湿痹拘挛、腰膝关节酸重疼痛、吐泻转筋、脚气水肿;
僵蚕,性味:咸、辛、平,具有祛风定惊、化痰散结之功效,用于治疗惊风抽搐、咽喉肿痛、皮肤瘙痒、颌下淋巴结炎、面神经麻痹等症;
白芍,性味:苦、酸、微寒,养血和营、缓急止痛、敛阴平肝之功效,用于治疗月经不调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症;
荆芥,性味:辛、温,具有发表、祛风、理血、炒炭止血之功效,用于治疗感冒发热、头痛、咽喉肿痛、中风口噤、吐血、衄血、便血、崩漏、产后血晕、痈肿、疮疥、瘰疬等症;
白芥子,性味:味辛、辣,具有温肺豁痰利气、乳腺散结通络止痛之功效,用于治疗寒痰喘咳、胸胁胀痛、痰滞经络、关节麻木、疼痛、痰湿流注、阴疽肿毒;
生石膏,性味:味甘、辛、性大寒,生用:具有清热泻火、除烦止渴;煅用:具有敛疮生肌、收湿、止血之功效,用于治疗外感热病、高热烦渴、肺热喘咳、胃火亢盛、头痛、牙痛等症;
羌活,性味:辛苦、温,具有散表寒、祛风湿、利关节之功效,用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒;
人参,性味:甘微苦、温,具有大补元气、固脱生津、安神之功效,用于治疗劳伤虚损、食少、倦怠、反胃吐食、大便滑泄、虚咳喘促、自汗暴脱、惊悸、健忘、眩晕头痛、阳痿、尿频、消渴、妇女崩漏、小儿慢惊、及久虚不复、一切气血津液不足等症;
蝉蜕,性味:味甘、咸、性凉,具有宣散风热、透疹利咽、退翳明目、祛风止痉之功效,用于治疗风热感冒、咽喉肿痛、咳嗽音哑、单板机疹不透、风疹瘙痒、目赤翳障、惊痫抽搐、破伤风等症;
全蝎,性味:味辛、性平,有毒,具有祛风止痉、通络止痛、玫毒散结之功效,用于治疗小儿惊风、抽搐痉挛、中风口、半身不遂、破伤风、风湿顽痹、偏正头痛、牙痛、耳聋、痈肿疮毒、瘰疬痰核、蛇咬、烧伤、风疹、顽癣等症;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒等症。
本发明药物是基于中医治疗头痛的原则,从依据头痛的病理机制及药理作用认为:就头痛,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述头痛的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗头痛的丸剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
徐长卿115g、菊花80g、蔓荆子95g、栀子95g、白芷95g、麦冬200g、独活80g、沙棘80g、羌活200g、龙胆草52g、生地黄260g、防风95g、酒黄芩80g、细辛26g、罗勒120g、红花95g、柴胡95g、 天麻95g、半夏70g、黄芪280g、葛根120g、川芎80g、山楂95g、枳实95g、石决明120g、苍耳子80g、藁本80g、酒大黄80g、延胡索95g、木瓜730g、僵蚕80g、白芍118g、荆芥120g、白芥子52g、生石膏580g、羌活200g、人参120g、蝉蜕95g、全蝎52g、甘草115g,辅料:淀粉适量。
实施例2:
一种治疗头痛的丸剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
徐长卿130g、菊花90g、蔓荆子105g、栀子105g、白芷105g、麦冬220g、独活90g、沙棘90g、羌活230g、龙胆草60g、生地黄310g、防风105g、酒黄芩90g、细辛31g、罗勒140g、红花105g、柴胡105g、 天麻105g、半夏80g、黄芪310g、葛根140g、川芎90g、山楂105g、枳实105g、石决明140g、苍耳子90g、藁本90g、酒大黄90g、延胡索105g、木瓜850g、僵蚕90g、白芍130g、荆芥140g、白芥子60g、生石膏660g、羌活230g、人参140g、蝉蜕105g、全蝎60g、甘草130g,辅料:淀粉适量。
实施例3:
一种治疗头痛的丸剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
徐长卿150g、菊花100g、蔓荆子120g、栀子120g、白芷120g、麦冬250g、独活100g、沙棘100g、羌活260g、龙胆草70g、生地黄350g、防风120g、酒黄芩100g、细辛35g、罗勒160g、红花120g、柴胡120g、 天麻120g、半夏90g、黄芪350g、葛根160g、川芎100g、山楂120g、枳实120g、石决明160g、苍耳子100g、藁本100g、酒大黄100g、延胡索120g、木瓜1000g、僵蚕100g、白芍150g、荆芥160g、白芥子70g、生石膏750g、羌活260g、人参160g、蝉蜕120g、全蝎70g、甘草150g,辅料:淀粉适量。
典型病例
经临床诊断治疗头痛患者共975例,年龄为62岁以上的605例,只有370例为62岁以下。975例患者中痊愈的610例,有效的336例,无效的29例。总有效率达97%。
Claims (3)
1.一种治疗头痛的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
徐长卿30~150g、菊花50~100g、蔓荆子50~120g、栀子60~120g、白芷30~120g、麦冬100~250g、独活30~100g、沙棘30~100g、羌活100~260g、龙胆草30~70g、生地黄100~350g、防风50~120g、酒黄芩30~100g、细辛10~35g、罗勒50~160g、红花50~120g、柴胡30~120g、 天麻30~120g、半夏30~90g、黄芪90~350g、葛根90~160g、川芎50~100g、山楂30~120g、枳实30~120g、石决明90~160g、苍耳子30~100g、藁本30~100g、酒大黄40~100g、延胡索30~120g、木瓜600~1000g、僵蚕50~100g、白芍50~150g、荆芥80~160g、白芥子30~70g、生石膏150~750g、羌活100~260g、人参25~160g、蝉蜕50~120g、全蝎20~70g、甘草30~150g,辅料:淀粉适量。
2.根据权利要求1所述的治疗头痛的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
徐长卿38~130g、菊花58~90g、蔓荆子58~105g、栀子70~105g、白芷38~105g、麦冬115~220g、独活38~90g、沙棘38~90g、羌活115~230g、龙胆草38~60g、生地黄115~310g、防风58~105g、酒黄芩38~90g、细辛12~31g、罗勒58~140g、红花58~105g、柴胡38~105g、 天麻38~105g、半夏38~80g、黄芪100~310g、葛根100~140g、川芎58~90g、山楂38~105g、枳实38~105g、石决明100~140g、苍耳子38~90g、藁本38~90g、酒大黄48~90g、延胡索38~105g、木瓜700~850g、僵蚕58~90g、白芍58~130g、荆芥90~140g、白芥子38~60g、生石膏180~660g、羌活115~230g、人参30~140g、蝉蜕58~105g、全蝎26~60g、甘草38~130g,辅料:淀粉适量。
3.根据权利要求1至2所述的治疗头痛的丸剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
徐长卿115g、菊花80g、蔓荆子95g、栀子95g、白芷95g、麦冬200g、独活80g、沙棘80g、羌活200g、龙胆草52g、生地黄260g、防风95g、酒黄芩80g、细辛26g、罗勒120g、红花95g、柴胡95g、 天麻95g、半夏70g、黄芪280g、葛根120g、川芎80g、山楂95g、枳实95g、石决明120g、苍耳子80g、藁本80g、酒大黄80g、延胡索95g、木瓜730g、僵蚕80g、白芍118g、荆芥120g、白芥子52g、生石膏580g、羌活200g、人参120g、蝉蜕95g、全蝎52g、甘草115g,辅料:淀粉适量。
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