CN107970489A - Carry preparation method of injectable type bone cement of medicine organic phosphoric acid modified zirconia and products thereof and application - Google Patents
Carry preparation method of injectable type bone cement of medicine organic phosphoric acid modified zirconia and products thereof and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/222—Gelatin
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The present invention relates to a kind of preparation method of injectable type bone cement for carrying medicine organic phosphoric acid modified zirconia and products thereof and application, using α TCP as body of powder, using the organic phosphoric acid zirconium nano particle of carrying medicament as modifying agent, syringeability is improved with gelatin, organic phosphoric acid zirconium nano particle is prepared by direct precipitation method；Zirconium phosphate particles and pharmaceutical aqueous solution are mixed, make Drug absorbability in zirconium phosphate particles it is layered mesoporous in；Gelatin is coated on α TCP powder by the way of solution disperses, freezes, improve the syringeability and anti-collapsibility of bone cement；After bone cement reconciliation slurry is injected in vivo, phosphonyl group promotes bone cement to cure, and reduces the risk that bone cement leaks, and medicine is discharged by diffusion, reaches sustained release purpose.Material injection is good, and hardening time is suitable, and medicinal application scope is wide, possesses preferable slow-release capability, has broad application prospects in clinical Bone Defect Repari field.
Description
Technical field
The present invention relates to a kind of biology medical material technical field, is specifically a kind of noting for load medicine organic phosphoric acid modified zirconia
Preparation method of emitting calcium phosphate bone cement and products thereof and application, using α-TCP as body of powder, with the organophosphor of carrying medicament
Sour zirconium nano particle is modifying agent, improves syringeability with gelatin, and the good injectable type of injectivity is prepared and carries medicine phosphoric acid
Calcium bone cement.
Background technology
Calcium phosphate bone cement is a kind of new bone renovating material, due to the inorganic constituents phase of its chemical composition and nature bone
Seemingly, there is good osteoconductive, osteoinductive and biological degradability；By adding suitable modifying agent, improve material can
Injectivity and anti-collapsibility, can be prepared into Injectable calcium-phosphate bone cement, micro- for implementing the Orthopedic Clinicals such as vertebroplasty
Invasive procedures.Meanwhile calcium phosphate bone cement is also a kind of good pharmaceutical carrier, medicine, Pharmaceutical carrier particles are supported on bone cement
Reconcile in slurry, after the minimally invasive injection, curing in vivo by bone cement, can be peeled off by solution diffusion or degraded from bone cement
In slowly discharge, meet the demand of local, long-acting drug therapy.Common medicine includes antibiotic property medicine, antitumor drug
And Bone formation class growth factor etc..
Organic phosphoric acid zirconium compounds has good heat endurance, chemical stability, bigger serface, programmable stratiform
Structure, has been widely used in the fields such as ion exchange, catalytic materials, photoelectric material, environmental protection.The layered mesoporous of it can pass through
Suction-operated carrying medicament, has important application potential as drug carrier material.Meanwhile the phosphonate group on organic phosphoric acid zirconium
Group can couple calcium ion, promote the progress of bone cement hydration reaction, shorten the hardening time of bone cement, reduce bone cement in body
The interior risk leaked.
The content of the invention
For overcome the deficiencies in the prior art, noting for medicine organic phosphoric acid modified zirconia is carried it is an object of the invention to provide a kind of
The preparation method of emitting calcium phosphate bone cement.
Another object of the present invention is：A kind of injectable of load medicine organic phosphoric acid modified zirconia prepared by above method is provided
Type calcium phosphate bone cement product.
A further object of the present invention is：A kind of application of the said goods is provided.
The object of the invention is realized by following proposal：A kind of system for the injectable type bone cement for carrying medicine organic phosphoric acid modified zirconia
Preparation Method, with high temperature calcium phosphate bone cement（α-TCP）Powder is main body, and the organic phosphoric acid zirconium nano particle using carrying medicament is changes
Property agent, syringeability is improved with gelatin, the good injectable type of injectivity is prepared and carries medicine calcium phosphate bone cement, comprising following
Step：
（1）α-TCP powder is prepared using solid reaction process, it is the bright of 0.05-0.5% to add mass fraction in the ratio of 1g/2mL
Sol solution, it is 0.1-1% to make α-TCP powder load gelatin mass fractions, is freezed after 1000-1500rpm high-speed stirreds 0.5h
It is dry, gelatin modified α-TCP powder is prepared；
（2）Organic phosphoric acid zirconium is prepared using direct precipitation method, above-mentioned powder is added into pharmaceutical aqueous solution, stirring, washing, filter
Afterwards, in 50-60 DEG C of vacuum drying, obtain carrying medicine organic phosphoric acid zirconium nano particle；
（3）Medicine organic phosphoric acid zirconium nano particle will be carried and added by mass fraction 0.1-5% in above-mentioned gelatin modified α-TCP powder and filled
After dividing mixing, reconciled with solidify liquid by liquid-solid ratio 0.3-0.4mL/g, be prepared and carry noting for medicine organic phosphoric acid modified zirconia
Emitting bone cement.
Zirconium phosphate particles are added drug solution, stirring, take out by the present invention using direct precipitation method synthesis organic phosphoric acid zirconium
Filter, lyophilized prepare carry medicine zirconium phosphate nano particle, make Drug absorbability in zirconium phosphate particles it is layered mesoporous in, utilize its stratiform to be situated between
The carried medicine sustained-release ability in hole, improves calcium phosphate bone cement Drug loading capacity, the clinical application range of widened material；Using solution point
The mode dissipate, freezed makes gelatin be coated on α-TCP powder, improves the syringeability and anti-collapsibility of bone cement；Gelatin changes
The high temperature calcium phosphate bone cement of property（α-TCP）Powder is mixed with carrying medicine zirconium phosphate nano particle, after being reconciled with solidify liquid, is prepared into
After being injected in vivo to injectable type load medicine calcium phosphate bone cement, phosphonyl group promotes bone cement to cure, and reduces bone cement and leaks
Risk, medicine discharged by diffusion, reaches sustained release purpose.
Step（1）The solid reaction process is by raw material calcium monohydrogen phosphate and calcium carbonate in molar ratio 2:After 1 is sufficiently mixed,
2-4h and rapid cooling are calcined at 1250-1400 DEG C to room temperature, using absolute ethyl alcohol for ball-milling medium 450rpm progress ball milling 2-4h,
Product is placed in 60 DEG C of baking ovens dry.
Step（2）The direct precipitation method adds ultra-pure water dilution for 40%HF solution in plastic cup, is slowly added to
ZrOCl2 8H2O solution, stirs 30min, organic phospho acid solution is slowly added dropwise after the reaction was complete again, the molar ratio for making three is
HF：ZrOCl2•8H2O：Organic phospho acid is 6：1：1, react 72h in 70 DEG C of stirred in water bath.Product milli-Q water, filter,
In 60 DEG C of vacuum drying.
Step（2）The medicine includes silver ion, the zinc ion solution of antibiotic property, water miscible antibacterials, anticancer
Medicine, promote bone growth factor etc..
Step（3）The load medicine organic phosphoric acid zirconium nano particle and the hybrid mode of gelatin modified α-TCP powder be
150rpm dry ball millings.
The present invention provides a kind of injectable type bone cement for carrying medicine organic phosphoric acid modified zirconia, according to any of the above-described the method
It is prepared.
The present invention provides a kind of application of injectable type bone cement for carrying medicine organic phosphoric acid modified zirconia in Bone Defect Repari.
Comprise the following steps that：
1st, by calcium monohydrogen phosphate and calcium carbonate in molar ratio 2:1 is uniformly mixed.The hybrid mode is that ultra-pure water is under ball-milling medium
400rpm ball milling mixings, incorporation time 2-4h, mixed suspension are placed in 130 DEG C of baking ovens dry.
2nd, above-mentioned dried raw material is placed in 1250-1400 DEG C of Muffle furnace high temperature calcining 2-4h, takes out after reaction,
The rapid cooling in air blast environment, obtains α-TCP powder.Product is subjected to ball milling 2- by ball-milling medium 450rpm of absolute ethyl alcohol
4h, the suspension after ball milling remove ethanol using Rotary Evaporators, are placed in 60 DEG C of baking ovens and are dried overnight.
3rd, the aqueous gelatin solution that mass fraction is 0.05-0.5% is prepared.α-TCP powder and upper gelatine solution are pressed into 1g/
The ratio mixing of 2mL, makes α-TCP powder load gelatin mass fractions be 0.1-1%, 1000-1500rpm high-speed stirred 0.5h, into
Row freeze-drying, is prepared gelatin modified α-TCP powder.
4th, 40%HF solution is weighed in plastic cup, is added ultra-pure water and is uniformly mixed, is slowly added to ZrOCl2·8H2O solution,
30min is stirred, organic phospho acid solution, the lower reaction 72h of 70 DEG C of stirrings is slowly added dropwise after the reaction was complete again.The ultrapure washing of product
Wash, filter, 50-60 DEG C of vacuum drying.Above-mentioned zirconium phosphate particles are weighed, add certain density drug solution, under the conditions of lucifuge
It is sufficiently stirred, filters, in 50-60 DEG C of vacuum drying, is prepared and carries medicine zirconium phosphate nano particle.
5th, the disodium hydrogen phosphate aqueous solution that mass fraction is 2.5% is prepared.The manner of formulation of the solution is to stir at room temperature
Dissolving, agitating mode is magnetic agitation or mechanical agitation.Above-mentioned solution is stored for future use as bone cement solidify liquid.
6th, medicine zirconium phosphate nano particle will be carried to add in gelatin modified α-TCP powder by mass fraction 0.1-5%, low speed is done
Method ball milling mixing is uniform, is reconciled with bone cement solidify liquid by liquid-solid ratio 0.3-0.4mL/g, that is, obtain injectivity it is good can
Injection-type carries medicine calcium phosphate bone cement.
Pin of the present invention utilizes layer using the organic phosphoric acid zirconium nano particle of carrying medicament as the modifying agent of calcium phosphate bone cement
The mesoporous carried medicine sustained-release ability of shape, improves calcium phosphate bone cement Drug loading capacity, the clinical application range of widened material；Meanwhile
Shorten the hardening time of calcium phosphate bone cement, it is met the needs of clinical Minimally Invasive Surgery.Prepared by direct precipitation method organic
Zirconium phosphate nano particle；Zirconium phosphate particles and pharmaceutical aqueous solution are mixed, make Drug absorbability in the stratiform of zirconium phosphate particles
In mesoporous；Gelatin is coated on α-TCP powder by the way of solution disperses, freezes, improve the syringeability of bone cement
With anti-collapsibility；After bone cement reconciliation slurry is injected in vivo, phosphonyl group promotes bone cement to cure, and reduces the wind that bone cement leaks
Danger, medicine are discharged by diffusion, reach sustained release purpose.
The advantage of the invention is that：
1st, the present invention, using the stability and meso-hole structure of basic zirconium phosphate, expands load using organic phosphoric acid zirconium as Pharmaceutical carrier particles
The scope of medicine, improves slow-release capability of the material to medicine；The hardening time of bone cement can be shortened at the same time, reduce clinical generation bone
The risk of cement leakage.
2nd, preparation method provided by the invention is simple, meets the demand of Clinical practice, has broad application prospects.
Embodiment
Following embodiments are implemented premised on inventive technique scheme, give detailed embodiment and specific behaviour
Make process, but protection scope of the present invention is not limited to following embodiments.
Raw material prepares and test method：
（1）It is prepared by gelatin modified α-TCP powder：
By Dicalcium Phosphate and calcium carbonate powder in molar ratio 2:1 weighs, wet as medium using 1.5 times of ultra-pure water of gross mass
Method ball milling, rotating speed 400rpm, Ball-milling Time 4h, ball milling pearl are 3 with powder quality ratio:1, ball milling is placed in 130 DEG C of baking ovens and does
It is dry.Dried powder is placed in 1400 DEG C of Muffle furnace high temperature calcining 4h, is taken out after reaction, under air blast environment rapidly
Cooling.Powder after cooling is added into absolute ethyl alcohol wet ball grinding with the ratio of 1g/mL, rotating speed 450rpm, Ball-milling Time 4h,
Ball milling pearl is 4 with powder quality ratio:1.Powder suspension removes ethanol using Rotary Evaporators and is placed in 60 DEG C of baking ovens fully
It is dry, α-TCP powder is prepared.0.02g Gelatins are weighed in 40mL ultra-pure waters, 50 DEG C of heating stirrings promote dissolving,
Then 20g α-TCP powder is added into aqueous solution, liquid nitrogen snap frozen is used after 1500rpm high-speed stirreds 0.5h, is freezed
Dry more than 48h, is prepared gelatin modified α-TCP powder.
（2）The preparation of organic phosphoric acid zirconium：
Appropriate 40%HF solution is measured in plastic cup, ultra-pure water dilution is added, stirs evenly.ZrOCl is slowly added dropwise2·8H2O
Solution, stirs 30min, organic phospho acid solution is slowly added dropwise after the reaction was complete again, the molar ratio for making three is HF：ZrOCl2·
8H2O：Organic phospho acid is 6：1：1, react 72h in 70 DEG C of stirred in water bath.Product milli-Q water, filter, in 60 DEG C of vacuum
It is dry, organic phosphoric acid zirconium powder is prepared.
（3）Injectability coefficient is tested
It is 20mm by internal diameter, the 20mL syringes of distal opening internal diameter 2mm are vertically arranged on mechanics tester tablet, by bone cement
Powder is uniformly mixed by certain proper ratio with solidify liquid and is placed in syringe, is tested when 120s after mixing.With speed
15mm/min is promoted and is released bone cement, until maximum propulsive force stops when being 100N.The bone cement weight of release is accounted for into gross weight
The percentage of amount is as injectability coefficient.
（4）Antibacterial tests are tested：
Bone cement inserts φ 6*12cm after reconciling3Mould, is placed in 37 DEG C of 100% humidity environment and fully cures 24h.Reference standard
GB/T21510-2008 Appendix B test material antibiotic properties, using Escherichia coli as test strain.Take large intestine bar more than culture three generations
Bacterium, suitable concentration is diluted to PBS buffer solutions（About 105cfu/mL）；Weigh antibacterial bone cement 1.0g ± 0.05g and be put into three
In the bottle of angle, after adding PBS mixing of the 95mL containing 0.1% Tween-80, the above-mentioned prefabricated bacteria suspensions of 5.0mL are added.Control group is by upper
State method and prepare the bacteria suspension without antibacterial bone cement.Test group and control group are placed in 37 DEG C of 150rpm constant-temperature tables and vibrated
It is incubated 2-4h.After vibration, test group and control group pass through appropriate dilution, are inoculated in the plate containing agar medium
On, each concentration sets 2 Duplicate Samples, and above-mentioned plate is cultivated 24h in 37 DEG C of incubators, does viable bacteria culture and counts.
Embodiment 1
Weigh above-mentioned（2）The phosphoric acid zirconium powder 1g of preparation adds 20mL 0.2mol/L silver nitrate solutions, and magnetic force stirs under the conditions of lucifuge
2h is mixed, suction filtration, milli-Q water more than 2 times, filter cake is dried under vacuum to constant weight in 60 DEG C, is crushed with pulverizer, and load is prepared
Medicine phosphoric acid zirconium powder；
The load medicine phosphoric acid zirconium powder of mass fraction 1% is added in above-mentioned（1）In prepared gelatin modified α-TCP powder, 150rpm
Dry ball milling 2h obtains bone cement powder；
The disodium hydrogen phosphate aqueous solution that preparation mass fraction is 2.5% is consolidated solidify liquid with bone cement powder as solidify liquid by liquid
Reconciled than 0.35mL/g, the reference standard ASTM C191 measure presetting periods are 9min, final setting time 22min；By above-mentioned
（3）Test injection capacity factor is 95%, not defeated and dispersed in water；By above-mentioned（4）Test material antibiotic property, antibiotic rate 91%.
Embodiment 2
Weigh above-mentioned（2）The phosphoric acid zirconium powder 1g of preparation adds 20mL 0.2mol/L silver nitrate solutions, and magnetic force stirs under the conditions of lucifuge
2h is mixed, suction filtration, milli-Q water more than 2 times, filter cake is dried under vacuum to constant weight in 60 DEG C, is crushed with pulverizer, and load is prepared
Medicine phosphoric acid zirconium powder；
The load medicine phosphoric acid zirconium powder of mass fraction 5% is added in above-mentioned（1）In made gelatin modified α-TCP powder, 150rpm dry method
Bone cement powder is made in ball milling 2h；
The disodium hydrogen phosphate aqueous solution that preparation mass fraction is 2.5% is consolidated solidify liquid with bone cement powder as solidify liquid by liquid
Reconciled than 0.35mL/g, the reference standard ASTM C191 measure presetting periods are 7min, final setting time 18min；By above-mentioned
（3）Test injection capacity factor is 95%, not defeated and dispersed in water；By above-mentioned（4）Test material antibiotic property, antibiotic rate 99%.
Embodiment 3
Weigh above-mentioned（2）The phosphoric acid zirconium powder 1g of preparation adds 20mL 0.5mg/mL vancomycin hydrochloride solution, lucifuge condition
Lower magnetic agitation 2h, suction filtration, milli-Q water more than 2 times, filter cake is dried under vacuum to constant weight in 60 DEG C, is crushed with pulverizer, system
It is standby to obtain carrying medicine phosphoric acid zirconium powder；
The load medicine phosphoric acid zirconium powder of mass fraction 5% is added in above-mentioned（1）In made gelatin modified α-TCP powder, 150rpm dry method
Bone cement powder is made in ball milling 2h；
The disodium hydrogen phosphate aqueous solution that preparation mass fraction is 2.5% is consolidated solidify liquid with bone cement powder as solidify liquid by liquid
Reconciled than 0.35mL/g, the reference standard ASTM C191 measure presetting periods are 7min, final setting time 18min；By above-mentioned
（3）Test injection capacity factor is 95%, not defeated and dispersed in water.
Claims (8)
1. a kind of preparation method for the injectable type bone cement for carrying medicine organic phosphoric acid modified zirconia, it is characterised in that with high temperature calcium phosphate
Bone cement（α-TCP）Powder is main body, and using the organic phosphoric acid zirconium nano particle of carrying medicament as modifying agent, being improved with gelatin to note
Penetrating property, is prepared the good injectable type of injectivity and carries medicine calcium phosphate bone cement, comprise the steps of：
（1）α-TCP powder is prepared using solid reaction process, it is 0.05-0.5%'s to be added to mass fraction in the ratio of 1g/2mL
In gelatin solution, it is 0.1-1% to make α-TCP powder load gelatin mass fractions, is carried out after 1000-1500rpm high-speed stirreds 0.5h
Freeze-drying, is prepared gelatin modified α-TCP powder；
（2）Organic phosphoric acid zirconium powder is prepared using direct precipitation method, which is added in pharmaceutical aqueous solution, is stirred
After mixing, wash, filtering, in 50-60 DEG C of vacuum drying, obtain carrying medicine organic phosphoric acid zirconium nano particle；
（3）Medicine organic phosphoric acid zirconium nano particle will be carried and added by mass fraction 0.1-5% in above-mentioned gelatin modified α-TCP powder and filled
Divide mixing, then, reconciled with solidify liquid by liquid-solid ratio 0.3-0.4mL/g, be prepared and carry medicine organic phosphoric acid modified zirconia
Injectable type bone cement.
2. the preparation method of the injectable type bone cement according to claim 1 for carrying medicine organic phosphoric acid modified zirconia, its feature
It is, step（1）The solid reaction process is by raw material calcium monohydrogen phosphate and calcium carbonate in molar ratio 2:After 1 is sufficiently mixed,
Simultaneously to room temperature, ball milling 2-4h, production are carried out by ball-milling medium 450rpm of absolute ethyl alcohol to 1250-1400 DEG C of calcining 2-4h for rapid cooling
Thing is placed in 60 DEG C of baking ovens dry.
3. the preparation method of the injectable type bone cement according to claim 1 for carrying medicine organic phosphoric acid modified zirconia, its feature
It is, step（2）Described in direct precipitation method prepare the method for organic phosphoric acid zirconium powder and be：40%HF solution adds in measuring cup
Enter ultra-pure water dilution, be slowly added to ZrOCl2 8H2O solution, stir 30min, it is molten that organic phospho acid is slowly added dropwise after the reaction was complete again
Liquid, the molar ratio for making three are HF：ZrOCl2•8H2O：Organic phospho acid is 6：1：1, react 72h, production in 70 DEG C of stirred in water bath
Thing milli-Q water, filter, and organic phosphoric acid zirconium powder is made in 60 DEG C of vacuum drying.
4. the preparation method of the injectable type bone cement of the load medicine organic phosphoric acid modified zirconia according to claim 1 or 3, it is special
Sign is that organic phosphoric acid zirconium powder is added in pharmaceutical aqueous solution, which includes silver ion, the zinc ion solution of antibiotic property, water
The antibacterials of dissolubility, cancer therapy drug, rush bone growth factor.
5. the preparation method of the injectable type bone cement according to claim 1 for carrying medicine organic phosphoric acid modified zirconia, its feature
It is, step（3）The hybrid mode of the load medicine organic phosphoric acid zirconium nano particle and gelatin modified α-TCP powder is 150rpm
Dry ball milling.
6. the preparation method of the injectable type bone cement according to claim 1 for carrying medicine organic phosphoric acid modified zirconia, its feature
It is, step（3）Described in solidify liquid be mass fraction 2.5% disodium hydrogen phosphate aqueous solution.
7. a kind of injectable type bone cement for carrying medicine organic phosphoric acid modified zirconia, it is characterised in that according to any institutes of claim 1-6
The method of stating is prepared.
8. a kind of carry the injectable type bone cement of medicine organic phosphoric acid modified zirconia answering in Bone Defect Repari according to claim 7
With.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113304313A (en) * | 2020-12-29 | 2021-08-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation of injectable calcium phosphate bone cement modified by drug-loaded rare earth MOF, and product and application thereof |
| CN114225108A (en) * | 2021-12-17 | 2022-03-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of high-viscosity anti-seepage PMMA bone cement, product and application thereof |
| CN115737932A (en) * | 2022-11-23 | 2023-03-07 | 国纳之星(上海)纳米科技发展有限公司 | Preparation of bone cement loaded with X-ray induced photodynamic therapy/radiotherapy collaborative diagnosis and treatment integrated probe, product and application |
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| CN114225108A (en) * | 2021-12-17 | 2022-03-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of high-viscosity anti-seepage PMMA bone cement, product and application thereof |
| CN115737932A (en) * | 2022-11-23 | 2023-03-07 | 国纳之星(上海)纳米科技发展有限公司 | Preparation of bone cement loaded with X-ray induced photodynamic therapy/radiotherapy collaborative diagnosis and treatment integrated probe, product and application |
| CN115737932B (en) * | 2022-11-23 | 2024-04-26 | 国纳之星(上海)纳米科技发展有限公司 | Preparation, product and application of bone cement loaded with X-ray induced photodynamic therapy/radiotherapy cooperative diagnosis and treatment integrated probe |
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