CN107899523A - A kind of gelatin soft capsule and preparation method thereof - Google Patents
A kind of gelatin soft capsule and preparation method thereof Download PDFInfo
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- CN107899523A CN107899523A CN201711205035.9A CN201711205035A CN107899523A CN 107899523 A CN107899523 A CN 107899523A CN 201711205035 A CN201711205035 A CN 201711205035A CN 107899523 A CN107899523 A CN 107899523A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
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Abstract
The present invention provides a kind of gelatin soft capsule and preparation method thereof, which solves the easy permeability of existing gelatin soft capsule, fragmentation and the technical problem of adhesion, is calculated with parts by weight, the rubber of gelatin soft capsule contains the component of following parts by weight parts per hundred parts：5~20 parts of gelatin for freezing power intensity 120g, 5~15 parts of the gelatin, 5~10 parts of gelatin, 20~35 parts of 5~10 parts of gelatin, the glycerine and 20~40 parts of water of jelly power intensity 220g of jelly power intensity 180g that freeze power intensity 150g, the present invention additionally provides its preparation method at the same time, the composite can be widely applied to the preparation of gelatin soft capsule.
Description
Technical field
The present invention relates to a kind of capsule and preparation method thereof, more particularly, to a kind of gelatin soft capsule and preparation method thereof.
Background technology
Gelatin soft capsule is that oil type liquid, suspension etc. are quantitatively encapsulated in its film by gelatin film, so as to be formed big
Small, different soft capsule.The quality of gelatin soft capsule quality is related with two big factors, when the containment of gelatin film, its
It is related with gelatin characteristic by capsule skin proportioning to encapsulate performance；Second, the stability of content objects system, but made by a variety of supplementary materials
Content objects system is complex, it is difficult to distinguishes whether it can be used in soft capsule.This two big factor has led to gelatin soft capsule
Easily there is a series of problems, such as oil leak, permeability, fragmentation and adhesion etc. during compacting or preservation in product.
The content of the invention
The present invention is aiming at the easy permeability of existing gelatin soft capsule, fragmentation and the technical problem of adhesion, there is provided one kind is not easy
It is permeability, not easily broken and be not easy gelatin soft capsule of adhesion and preparation method thereof.
The present invention provide one kind is calculated with parts by weight, parts per hundred parts the rubber of gelatin soft capsule contain following parts by weight into
Point：5~20 parts of gelatin freezing power intensity 120g, 5~15 parts of gelatin for freezing power intensity 150g, freeze the gelatin 5 of power intensity 180g~
10 parts, 20~35 parts of 5~10 parts of gelatin, the glycerine and 20~40 parts of water of jelly power intensity 220g.
Preferably, calculated with parts by weight, the rubber of gelatin soft capsule contains the component of following parts by weight parts per hundred parts：Freeze power
5 parts of the gelatin of intensity 120g, 15 parts of gelatin for freezing power intensity 150g, 10 parts of gelatin for freezing power intensity 180g, jelly power intensity 220g
20~40 parts of 10 parts of gelatin, 20~35 parts of glycerine and water.
The present invention also provides the preparation method of above-mentioned gelatin soft capsule, its step are as follows：
(1) glue is prepared：To the water and glycerine for changing addition formula ratio in glue tank, 85 DEG C are warming up to, by jelly power intensity by height
To the gelatin of low input formula ratio, persistently stirred after the completion of dispensing 15~20 minutes, then carry out vacuum outgas, rotary viscosity value
Reach 20000~25000mPas after pour into 50~55 DEG C of insulation barrels, stand place 1.5~2.5 it is small when after use；
(2) content feed liquid is prepared：Different content raw materials is weighed by formula ratio, puts into content dispensing and fully stirs
Mix, be uniformly mixed；
(3) suppress：Prepared glue in step (1) and prepared content feed liquid in step (2) are respectively implanted
Compacting in encapsulating machine, washs, dry soft capsule with 95% ethanol after cold wind sizing, finally chooses qualified soft capsule,
Packaging.
Preferably, the temperature that water is added in step (1) is 80~85 DEG C.
Preferably, step (2) if in contain beeswax, put into mixing again after needing to be heated thawing.
Preferably, the temperature that cold wind is shaped in step (3) is 20 DEG C, relative humidity 35%, when setting time is 4 small.
Preferably, drying temperature is 25 DEG C in step (3), relative humidity 30%, when drying time is 24 small.
It is contemplated that by using the gelatin of different jelly power intensity, plasticizer glycerine of arranging in pairs or groups, comes by adjusting additive amount
Improve the jelly force characteristic of gelatin, and then the encapsulating performance for influencing gelatin film adapts to the soft gelatin flexible glue of complex contents thing characteristic
Capsule, and optimize colloidal sol working procedure parameter, it ensure that product is unlikely to chipping because hardness is high, be unlikely to because of moisture height
And stick together；The gelatin collocation use of so a variety of high-concentration and low-concentrations can reduce original while final product quality is ensured at the same time
Expect cost.
Embodiment
Embodiment 1 (bee glue soft capsule)
(1) glue is prepared：40 parts of water (82 DEG C) and 20 parts of glycerine are added in glue tank to changing, 85 DEG C are warming up to, in 15 seconds
Successively input freeze 10 parts of the gelatin of power intensity 220g, 10 parts of gelatin for freezing power intensity 180g, 15 parts of gelatin for freezing power intensity 150g,
Freeze 5 parts of the gelatin of power intensity 120g, persistently stirred after the completion of dispensing 15 minutes, then carry out vacuum outgas, rotary viscosity value arrives
Poured into after up to 20000mPas in 50 DEG C of insulation barrels, stand place 2.5 it is small when after use；
(2) content feed liquid is prepared：20 parts of bee glue powders are weighed, puts into 80 parts of polyethylene glycol 400s and is sufficiently stirred, mixing is equal
It is even；
(3) suppress：Prepared glue in step (1) and prepared content feed liquid in step (2) are respectively implanted
Compacting in encapsulating machine, cold wind sizing (temperature is 20 DEG C, and relative humidity 35%, setting time is for 4 when small) afterwards with 95% second
Alcohol washing, dry (drying temperature is 25 DEG C, relative humidity 30%, when drying time is 24 small) obtain soft capsule, finally choose and close
The soft capsule of lattice, packaging.
Control group 1：Freeze 40 parts of the gelatin of power intensity 150g, 20 parts of glycerine, 40 parts of water；
Control group 2：Freeze 40 parts of the gelatin of power intensity 220g, 20 parts of glycerine, 40 parts of water；
Control group 1 and the preparation method of control group 2 are same as Example 1.
Embodiment 2 (lecithoid soft capsule)
(1) glue is prepared：40 parts of water (80 DEG C) and 20 parts of glycerine are added in glue tank to changing, 85 DEG C are warming up to, in 15 seconds
Successively input freeze 10 parts of the gelatin of power intensity 220g, 10 parts of gelatin for freezing power intensity 180g, 15 parts of gelatin for freezing power intensity 150g,
Freeze 5 parts of the gelatin of power intensity 120g, persistently stirred after the completion of dispensing 18 minutes, then carry out vacuum outgas, rotary viscosity value arrives
Poured into after up to 22000mPas in 53 DEG C of insulation barrels, stand place 2 it is small when after use；
(2) content feed liquid is prepared：80 parts of phosphatide liquid are weighed, puts into 20 parts of soya-bean oil ethyl esters and is sufficiently stirred, are uniformly mixed；
(3) suppress：Prepared glue in step (1) and prepared content feed liquid in step (2) are respectively implanted
Compacting in encapsulating machine, cold wind sizing (temperature is 20 DEG C, and relative humidity 35%, setting time is for 4 when small) afterwards with 95% second
Alcohol washing, dry (drying temperature is 25 DEG C, relative humidity 30%, when drying time is 24 small) obtain soft capsule, finally choose and close
The soft capsule of lattice, packaging.
Control group 3：Freeze 40 parts of the gelatin of power intensity 120g, 20 parts of glycerine, 40 parts of water；
Control group 4：Freeze 40 parts of the gelatin of power intensity 150g, 20 parts of glycerine, 40 parts of water；
Control group 3 and the preparation method of control group 4 are same as Example 2.
Embodiment 3 (fish oil soft capsule)
(1) glue is prepared：40 parts of water (85 DEG C) and 20 parts of glycerine are added in glue tank to changing, 85 DEG C are warming up to, in 15 seconds
Successively input freeze 10 parts of the gelatin of power intensity 220g, 10 parts of gelatin for freezing power intensity 180g, 15 parts of gelatin for freezing power intensity 150g,
Freeze 5 parts of the gelatin of power intensity 120g, persistently stirred after the completion of dispensing 20 minutes, then carry out vacuum outgas, rotary viscosity value arrives
Poured into after up to 25000mPas in 55 DEG C of insulation barrels, stand place 1.5 it is small when after use；
(2) content feed liquid is prepared：Weigh 100 parts of fish oil liquid.
(3) suppress：Prepared glue in step (1) and prepared content feed liquid in step (2) are respectively implanted
Compacting in encapsulating machine, cold wind sizing (temperature is 20 DEG C, and relative humidity 35%, setting time is for 4 when small) afterwards with 95% second
Alcohol washing, dry (drying temperature is 25 DEG C, relative humidity 30%, when drying time is 24 small) obtain soft capsule, finally choose and close
The soft capsule of lattice, packaging.
Control group 5：Freeze 40 parts of the gelatin of power intensity 180g, 20 parts of glycerine, 40 parts of water；
Control group 6：Freeze 40 parts of the gelatin of power intensity 220g, 20 parts of glycerine, 40 parts of water；
Control group 5 and the preparation method of control group 6 are same as Example 3.
In 3 embodiments of the above, the auxiliary material of content can be polyethylene glycol or soybean oil or other oils,
Generally auxiliary material can be selected as polyethylene glycol 400 by doing bee glue soft capsule.
Experimental comparison：
Dried finished product is packed in PET bottle, carries out Acceleration study (28 DEG C ± 2 of temperature, humidity 75% ± 5%) afterwards.
It is divided into new product, January, 2 months and four measurement points in March.Measure sense organ, moisture and elasticity.
(1) sensory evaluation parameter-adhesion situation
Normally：After bottle is inverted, capsule and pill directly scattered or fell in 5 seconds
Mild adhesion：Bottle be inverted, capsule and pill fall successively or 30s after start to fall
Adhesion：Bottle is inverted, and capsule and pill does not fall.
(2) it is elastic：Measured using food texture measurement.
Experimental result deck watch
It can be seen that from above experimental result：Three samples of bee glue soft capsule storage period are not in adhesion situation,
The water absorbing properties of auxiliary material polyethylene glycol 400 make the rapid dehydration of rubber, moisture it is rapidly losing so that soft capsule is not easy adhesion；But
Control group 1 uses 150g to freeze the gelatin of power, its hardness is elastic then be significantly worse than pair apparently higher than control group 2 and experimental group
According to group 2 and experimental group.From the point of view of each index surveys fluctuation with the time, compared to the control group 1 and 2, the elasticity and hardness of experimental group refer to
It is substantially small to mark degree of fluctuation.In general, for bee glue soft capsule, a variety of fingers for freezing power and mutually mixing soft capsule prepared by gelatin
Mark is better than the soft capsule of single gelatin, and stability is more preferable.Also there is same experimental result in lecithoid soft capsule and fish oil.
Only as described above, be only the present invention specific embodiment, when the model implemented of the present invention cannot be limited with this
Enclose, therefore the displacement of its equivalent assemblies, or the equivalent variations made according to scope of patent protection of the present invention and modification, it all should still belong to this hair
The category that bright claims are covered.
Claims (7)
1. a kind of gelatin soft capsule, it is characterised in that calculated with parts by weight, the rubber of gelatin soft capsule contains following parts per hundred parts
The component of parts by weight：5~20 parts of gelatin for freezing power intensity 120g, 5~15 parts of the gelatin, the jelly power intensity 180g that freeze power intensity 150g
5~10 parts of gelatin, freeze 20~35 parts of 5~10 parts of gelatin, the glycerine and 20~40 parts of water of power intensity 220g.
2. gelatin soft capsule according to claim 1, it is characterised in that calculated with parts by weight, parts per hundred parts soft-gelatin
The rubber of capsule contains the component of following parts by weight：5 parts of gelatin for freezing power intensity 120g, 15 parts of the gelatin, the jelly that freeze power intensity 150g
10 parts of the gelatin of power intensity 180g, 20~35 parts of 10 parts of gelatin, the glycerine and 20~40 parts of water for freezing power intensity 220g.
3. a kind of preparation method of gelatin soft capsule as claimed in claim 1 or 2, it is characterised in that step is as follows：
(1) glue is prepared：To the water and glycerine for changing addition formula ratio in glue tank, 85 DEG C are warming up to, by jelly power intensity from high to low
The gelatin of formula ratio is put into, is persistently stirred after the completion of dispensing 15~20 minutes, then carries out vacuum outgas, rotary viscosity value reaches
Poured into after 20000~25000mPas in 50~55 DEG C of insulation barrels, stand place 1.5~2.5 it is small when after use；
(2) content feed liquid is prepared：Different content raw materials is weighed by formula ratio, is sufficiently stirred after putting into dispensing, mixing is equal
It is even；
(3) suppress：Prepared content feed liquid in prepared glue in step (1) and step (2) is respectively implanted flexible glue
Compacting in capsule machine, wash, dry soft capsule with 95% ethanol after cold wind sizing, finally chooses qualified soft capsule, pack.
4. the preparation method of gelatin soft capsule according to claim 3, it is characterised in that water is added in the step (1)
Temperature is 80~85 DEG C.
5. the preparation method of gelatin soft capsule according to claim 3, it is characterised in that the step (2) if in contain bee
Wax, then need to put into mixing again after being heated thawing.
6. the preparation method of gelatin soft capsule according to claim 3, it is characterised in that cold wind is shaped in the step (3)
Temperature be 20 DEG C, relative humidity 35%, setting time for 4 it is small when.
7. the preparation method of gelatin soft capsule according to claim 3, it is characterised in that drying temperature in the step (3)
For 25 DEG C, relative humidity 30%, drying time for 24 it is small when.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711205035.9A CN107899523A (en) | 2017-11-27 | 2017-11-27 | A kind of gelatin soft capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711205035.9A CN107899523A (en) | 2017-11-27 | 2017-11-27 | A kind of gelatin soft capsule and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107899523A true CN107899523A (en) | 2018-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711205035.9A Pending CN107899523A (en) | 2017-11-27 | 2017-11-27 | A kind of gelatin soft capsule and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498480A (en) * | 2018-06-01 | 2018-09-07 | 江苏康缘阳光药业有限公司 | Prevented in Chinese medicinal soft capsule sol-process gelatin congeal power reduction process |
| CN109228085A (en) * | 2018-09-07 | 2019-01-18 | 北京服装学院 | A kind of new bio plastics and preparation method thereof |
| CN116747289A (en) * | 2023-07-31 | 2023-09-15 | 广东润科生物科技有限公司 | Fat-removing composition and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188565A (en) * | 2011-04-09 | 2011-09-21 | 荣成百合生物技术有限公司 | Weight-losing soft capsules and preparation method thereof |
-
2017
- 2017-11-27 CN CN201711205035.9A patent/CN107899523A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188565A (en) * | 2011-04-09 | 2011-09-21 | 荣成百合生物技术有限公司 | Weight-losing soft capsules and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 潘卫三: "《工业药剂学》", 31 August 2015, 中国医药科技出版社 * |
| 谢远宜: "药用明胶", 《明胶科学与技术》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498480A (en) * | 2018-06-01 | 2018-09-07 | 江苏康缘阳光药业有限公司 | Prevented in Chinese medicinal soft capsule sol-process gelatin congeal power reduction process |
| CN108498480B (en) * | 2018-06-01 | 2020-11-13 | 江苏康缘阳光药业有限公司 | Process for preventing gelatin freezing force from reducing in traditional Chinese medicine soft capsule sol process |
| CN109228085A (en) * | 2018-09-07 | 2019-01-18 | 北京服装学院 | A kind of new bio plastics and preparation method thereof |
| CN116747289A (en) * | 2023-07-31 | 2023-09-15 | 广东润科生物科技有限公司 | Fat-removing composition and preparation method thereof |
| CN116747289B (en) * | 2023-07-31 | 2024-03-29 | 广东润科生物科技有限公司 | Fat-removing composition and preparation method thereof |
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