CN107890381A - Antiproliferative, the IVCF of antithrombotic reagent coating that can be placed for a long time - Google Patents
Antiproliferative, the IVCF of antithrombotic reagent coating that can be placed for a long time Download PDFInfo
- Publication number
- CN107890381A CN107890381A CN201711201974.6A CN201711201974A CN107890381A CN 107890381 A CN107890381 A CN 107890381A CN 201711201974 A CN201711201974 A CN 201711201974A CN 107890381 A CN107890381 A CN 107890381A
- Authority
- CN
- China
- Prior art keywords
- metal filtration
- antiproliferative
- ivcf
- long time
- filtration silk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 23
- 230000001028 anti-proliverative effect Effects 0.000 title claims abstract description 21
- 230000002785 anti-thrombosis Effects 0.000 title claims abstract description 21
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 17
- 239000011248 coating agent Substances 0.000 title claims abstract description 17
- 238000000576 coating method Methods 0.000 title claims abstract description 17
- 239000002184 metal Substances 0.000 claims abstract description 54
- 229910052751 metal Inorganic materials 0.000 claims abstract description 54
- 238000001914 filtration Methods 0.000 claims abstract description 53
- 239000003814 drug Substances 0.000 claims abstract description 24
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 8
- 210000003462 vein Anatomy 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 229960002897 heparin Drugs 0.000 claims description 4
- 229920000669 heparin Polymers 0.000 claims description 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical class O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 3
- 210000003111 iliac vein Anatomy 0.000 claims description 3
- 230000000394 mitotic effect Effects 0.000 claims description 3
- 239000002840 nitric oxide donor Substances 0.000 claims description 3
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims description 3
- 229950004354 phosphorylcholine Drugs 0.000 claims description 3
- 210000001367 artery Anatomy 0.000 claims description 2
- 229910021483 silicon-carbon alloy Inorganic materials 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000010750 Metalloproteins Human genes 0.000 claims 1
- 108010063312 Metalloproteins Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 abstract description 10
- 208000007536 Thrombosis Diseases 0.000 abstract description 8
- 208000005189 Embolism Diseases 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 6
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 208000014674 injury Diseases 0.000 abstract description 4
- 208000010378 Pulmonary Embolism Diseases 0.000 description 11
- 206010051055 Deep vein thrombosis Diseases 0.000 description 9
- 210000003141 lower extremity Anatomy 0.000 description 5
- 210000002796 renal vein Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000003038 endothelium Anatomy 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- -1 carbide Chemical compound 0.000 description 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010037437 Pulmonary thrombosis Diseases 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- HMDDXIMCDZRSNE-UHFFFAOYSA-N [C].[Si] Chemical compound [C].[Si] HMDDXIMCDZRSNE-UHFFFAOYSA-N 0.000 description 1
- 230000002965 anti-thrombogenic effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
The present invention relates to technical field of medical instruments, more particularly to a kind of antiproliferative that can be placed for a long time, the IVCF of antithrombotic reagent coating；The present invention includes branch pipe, pipe sleeve and some metal filtration silks, and the both ends of metal filtration silk are connected in branch pipe and pipe sleeve and metal filtration silk is in male type so as to form a filter cage；The material of branch pipe and pipe sleeve is flexible material；The first medication coat for antithrombotic is scribbled on metal filtration silk；In the present invention, interception thrombus can be carried out by metal filtration silk, it is allowed to be not easy embolism, and filter take-off time can also be extended by the first medication coat on metal filtration silk, and the incidence for causing a series of complication such as difficult taking-up, injury of blood vessel or tear later because taking out can be reduced, branch pipe and pipe sleeve entangle the both ends of metal filtration silk, are allowed to be not easy injured blood vessel；The present invention is practical, easy to operate.
Description
Technical field
The present invention relates to technical field of medical instruments, more particularly to a kind of antiproliferative that can be placed for a long time, antithrombotic reagent
The IVCF of coating.
Background technology
At present, Deep vain thrombosis (deep venous thrombosis, DVT) and pulmonary thromboembolism (pulmonary
Thromboembolism, PE) the incidence of disease increase day by day.As the complication of DVT most serious, PE has very high hair
Sick rate and fatal rate.Shown according to epidemiology survey in recent years, the only PE in U.S. year number of the infected is 750,000~900,000
People, year, lethal number was 120,000~150,000.Pulmonary thromboembolism does not only have the high incidence of disease and fatal rate, and onset is hurried,
Progress is rapid, and general pulmonary thromboembolism patient, which dies from, to fall ill in initial one hour, and pulmonary thromboembolism also results in chronic pulmonary
High pressure, have a strong impact on the quality of life of patient.
Lower limb DVT is the main reason for causing PE, and document report shows that about 60%~70% lower limb DVT patient can send out
Raw pulmonary thromboembolism.Research is it is also shown that 90%~95% pulmonary thrombosis embolus derives from lower limb DVT.The small blood of in general
Bolt embolus is difficult to cause pulmonary thromboembolism, only when Thromboembolus diameter is more than 7.5mm, can just Acute Pulmonary Embolism is endangered
Machine life.
Due to PE high incidence, high fatal rate and high disability rate, how to prevent the concurrent PE of DVT and increasingly weighed by scholar
Depending on.Generally acknowledged effective precautionary measures include the strict bed rest of DVT acute stages, the anticoagulant therapy of system and placement vena cave filter at present
Device (vena cava filter, VCF).The anticoagulant therapy of system is considered as the main side for treating DVT and preventing PE generations
Method, including treatment by Low molecule heparin and subsequent oral warfarin treatment.
With increasing for lower-limb deep veins thrombus patient, clinically for prevention lower limb and pelvic veins system thrombus breaks loose after
Prolong that inferior caval vein is up to cause pulmonary embolism, the utilization rate of lower strong venous filter gradually increases.IVCF can pass through
Intervention means, the lower section of renal vein opening is positioned over by jugular vein or femoral venous puncture, also has thrombus below renal vein opening
In the presence of, IVCF can also be positioned over to renal vein overthe openings.At present, the species of IVCF is mainly divided
For permanent IVCF, recyclable IVCF and provisional IVCF.
Permanent IVCF is clinically applied earliest, but according to retrospective study, it is quiet to be implanted into permanent cavity of resorption
The patient of arteries and veins filter, because filter is as in foreign matter Preserving time body, a series of complication such as narrow, embolism, bleeding can be caused, after
Phase treats and prevention cost is higher, and existing clinical practice gradually decreases.Recyclable IVCF is that patient is spending pulmonary embolism
Filter is withdrawn by intervening means after high-risk period, its take-off time window is generally at 2 weeks or so, if Preserving time turns into permanent
IVCF.For some patientss then because in the short time blood vessel endothelium hyperplasia covering filter lead to not take out, turn into forever
Long property IVCF.Must be before endothelium covers filter framework and connecting conduit after provisional INFERIOR VENA CAVA FILTER PLACEMENT
Take out, clinically using less, the clinical short-term pulmonary embolism prevention for being usually used in pregnant woman, obesity surgery patient.
The anti-thrombogenic capacity deficiency of IVCF filtering at present, and it is placed in postoperative, easy generation blood vessel endothelium hyperplasia, blood vessel
Phenomena such as damage or tear.
The content of the invention
Described above in order to overcome the shortcomings of, it is an object of the invention to provide a kind of antiproliferative that can be placed for a long time, anti-blood
The IVCF of bolt medication coat, it can carry out interception thrombus by metal filtration silk, be allowed to be not easy embolism, and pass through
The first medication coat on metal filtration silk can also extend filter take-off time, and can reduce because taking-up causes to take out later
A series of incidence of complication such as difficult, injury of blood vessel or tear, its is simple in construction, easy to operate.
The present invention solve its technical problem technical scheme be：
A kind of antiproliferative that can be placed for a long time, the IVCF of antithrombotic reagent coating, it can be placed in renal vein in human body
Inferior caval vein position between iliac vein, wherein, including branch pipe, pipe sleeve and some metal filtration silks, the metal filtration
The both ends of silk be connected in the branch pipe and pipe sleeve and the metal filtration silk in male type so as to forming a filter cage；
The material of the branch pipe and pipe sleeve is flexible material；The first medicine painting for antithrombotic is scribbled on the metal filtration silk
Layer.
As a modification of the present invention, it is also coated with being used for antiproliferative second medication coat on the metal filtration silk.
As a further improvement on the present invention, first medication coat is closed by Phosphorylcholine, heparin, carbide, silicon-carbon
One or two kinds of composition described above in gold.
As the present invention further improvement, second medication coat by for the mitotic medicine of anti-cell,
Anti-inflammatory agent, metal protease inhibitors, nitric oxide donors composition.
As the further improvement of the present invention, the both ends of the metal filtration silk are socketed in the branch pipe and pipe sleeve respectively
It is interior.
As the further improvement of the present invention, the both ends of some metal filtration silks weld together to be distinguished again
It is socketed in the branch pipe and pipe sleeve.
As the further improvement of the present invention, the quantity of the metal filtration silk is 6 ~ 12.
As the further improvement of the present invention, the quantity of the metal filtration silk is 9.
As the present invention further improvement, a diameter of 1 millimeter ~ 20 millimeters of the metal filtration silk.
As the present invention further improvement, a diameter of 5 millimeters of the metal filtration silk.
In the present invention, interception thrombus can be carried out by metal filtration silk, is allowed to be not easy embolism, and pass through metal filtration
The first medication coat on silk can also extend filter take-off time, and can reduce because taking-up causes to take out difficult, blood later
A series of incidence of complication such as pipe damage or tear, branch pipe and pipe sleeve entangle the both ends of metal filtration silk, are allowed to not rapid wear
Blood trouble pipe；The present invention is practical, easy to operate.
Brief description of the drawings
For ease of explanation, the present invention is described in detail by following preferred embodiments and accompanying drawing.
Fig. 1 is the structural representation of the present invention；
Fig. 2 is the front view of the present invention；
Fig. 3 is the left view of the present invention；
Reference：1- branch pipes, 2- metal filtration silks, 3- pipe sleeves, 4- filtering verdants.
Embodiment
In the description of the invention, it is necessary to explanation, term " " center ", " on ", " under ", "left", "right", " vertical ",
The orientation or position relationship of the instruction such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, merely to
Be easy to the description present invention and simplify description, rather than instruction or imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" the 3rd " is only used for describing purpose, and it is not intended that instruction or hint relative importance.
In the description of the invention, it is necessary to illustrate, unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected, or be integrally connected；Can
To be mechanical connection or electrical connection；Can be joined directly together, can also be indirectly connected by intermediary, Ke Yishi
The connection of two element internals.For the ordinary skill in the art, with concrete condition above-mentioned term can be understood at this
Concrete meaning in invention.
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
A kind of antiproliferative that can be placed for a long time, the IVCF of antithrombotic reagent coating of the present invention, it can be placed in
Inferior caval vein position in human body between renal vein and iliac vein.
As shown in Figure 1, Figure 2 and Figure 3, under a kind of antiproliferative that can be placed for a long time of the invention, antithrombotic reagent coating
Vena cava filter, including branch pipe 1, pipe sleeve 3 and some metal filtration silks 2.
The both ends of metal filtration silk 2 be connected in branch pipe 1 and pipe sleeve 3 and metal filtration silk 2 in male type so as to shape
Into a filter cage 4, extraction efficiency can be improved, so as to consecutive complications caused by avoiding Permanent implantation etc., mitigate patient's body and mind and
Financial burden.
For the ease of being placed in human body, it is easy to take out, the material of branch pipe 1 and pipe sleeve 3 is flexible material.
The first medication coat for antithrombotic is scribbled on metal filtration silk 2, take-off time can be extended, is reduced because taking out
Cause the incidence for taking out a series of complication such as difficult, injury of blood vessel or tear later.
In the present invention, interception thrombus can be carried out by metal filtration silk 2, is allowed to be not easy embolism, and pass through metal mistake
The first medication coat in filter wire 2 can also extend filter take-off time, and can reduce because take out cause to take out later it is difficult,
A series of incidence of complication such as injury of blood vessel or tear, branch pipe 1 and pipe sleeve 3 entangle the both ends of metal filtration silk 2, are allowed to not
Easy damaged blood vessel.
In order to suppress blood vessel endothelium hyperplasia, it is also coated with being used for antiproliferative second medication coat on metal filtration silk 2.
The present invention provides a kind of embodiment of the first medication coat, and the first medication coat is by Phosphorylcholine, heparin, carbonization
One or two kinds of composition described above in thing, silicon-carbon alloy.
The present invention provides a kind of embodiment of the second medication coat, and the second medication coat is by for anti-cell mitosis
Medicine, anti-inflammatory agent, metal protease inhibitors, nitric oxide donors composition.
The present invention provides a kind of connected mode of metal filtration silk 2, and the both ends of metal filtration silk 2 are socketed in branch pipe 1 respectively
In pipe sleeve 3.
In order that metal filtration silk 2 is difficult for drop-off, the both ends of some metal filtration silks 2 weld together to be covered respectively again
It is connected in branch pipe 1 and pipe sleeve 3.
The present invention provides a kind of embodiment of metal filtration silk 2, and the quantity of metal filtration silk 2 is 6 ~ 12；Make
To be preferred, the quantity of metal filtration silk 2 is 9.
Further, a diameter of 1 millimeter ~ 20 millimeters of metal filtration silk；Preferably, a diameter of 5 milli of metal filtration silk
Rice.
In the present invention, for mitotic medicine Ke Yi Wei Xi Moluosi of anti-cell, the female ether of oxygen alkene, radiating streptozotocin D
Deng；The optional cortisone of anti-inflammatory agent.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (10)
1. a kind of antiproliferative that can be placed for a long time, the IVCF of antithrombotic reagent coating, it is quiet that it can be placed in kidney in human body
Inferior caval vein position between arteries and veins and iliac vein, it is characterised in that described including branch pipe, pipe sleeve and some metal filtration silks
The both ends of metal filtration silk be connected in the branch pipe and pipe sleeve and the metal filtration silk in male type so as to forming one
Individual filter cage；The material of the branch pipe and pipe sleeve is flexible material；For antithrombotic is scribbled on the metal filtration silk
One medication coat.
2. a kind of antiproliferative that can be placed for a long time according to claim 1, the IVCF of antithrombotic reagent coating,
Characterized in that, it is also coated with being used for antiproliferative second medication coat on the metal filtration silk.
3. a kind of antiproliferative that can be placed for a long time according to claim 1, the IVCF of antithrombotic reagent coating,
Characterized in that, first medication coat by Phosphorylcholine, heparin, carbide, silicon-carbon alloy it is one or two kinds of with
Upper composition.
4. a kind of antiproliferative that can be placed for a long time according to claim 2, the IVCF of antithrombotic reagent coating,
Characterized in that, second medication coat is by for the mitotic medicine of anti-cell, anti-inflammatory agent, metalloprotein enzyme level
Agent, nitric oxide donors composition.
5. a kind of antiproliferative that can be placed for a long time according to claim 1, the IVCF of antithrombotic reagent coating,
Characterized in that, the both ends of the metal filtration silk are socketed in the branch pipe and pipe sleeve respectively.
6. a kind of antiproliferative that can be placed for a long time according to claim 5, the IVCF of antithrombotic reagent coating,
Characterized in that, the both ends of some metal filtration silks weld together is socketed in the branch pipe and pipe sleeve respectively again
It is interior.
A kind of 7. inferior caval vein filter of antiproliferative that can be placed for a long time, antithrombotic reagent coating according to claim 5 or 6
Device, it is characterised in that the quantity of the metal filtration silk is 6 ~ 12.
8. a kind of antiproliferative that can be placed for a long time according to claim 7, the IVCF of antithrombotic reagent coating,
Characterized in that, the quantity of the metal filtration silk is 9.
9. a kind of antiproliferative that can be placed for a long time according to claim 1, the IVCF of antithrombotic reagent coating,
Characterized in that, a diameter of 1 millimeter ~ 20 millimeters of the metal filtration silk.
10. the inferior caval vein filter of a kind of antiproliferative that can be placed for a long time according to claim 1, antithrombotic reagent coating
Device, it is characterised in that a diameter of 5 millimeters of the metal filtration silk.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711201974.6A CN107890381A (en) | 2017-11-27 | 2017-11-27 | Antiproliferative, the IVCF of antithrombotic reagent coating that can be placed for a long time |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711201974.6A CN107890381A (en) | 2017-11-27 | 2017-11-27 | Antiproliferative, the IVCF of antithrombotic reagent coating that can be placed for a long time |
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| CN107890381A true CN107890381A (en) | 2018-04-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711201974.6A Pending CN107890381A (en) | 2017-11-27 | 2017-11-27 | Antiproliferative, the IVCF of antithrombotic reagent coating that can be placed for a long time |
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| CN108992202A (en) * | 2018-08-14 | 2018-12-14 | 内蒙古工业大学 | A kind of not damaged retrievable vena cava filter |
| CN109984860A (en) * | 2019-01-30 | 2019-07-09 | 张韬 | Intravascular filter |
| CN115670738A (en) * | 2022-12-28 | 2023-02-03 | 北京华脉泰科医疗器械股份有限公司 | Thrombolytic catheter filter and thrombolytic filter combination kit |
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| CN101843531A (en) * | 2010-05-25 | 2010-09-29 | 天健医疗科技(苏州)有限公司 | Medicament coated thrombus filter |
| CN205054504U (en) * | 2015-07-09 | 2016-03-02 | 张福先 | Recoverable vena cave filter |
| CN206499550U (en) * | 2016-12-02 | 2017-09-19 | 杭州唯强医疗科技有限公司 | A kind of vena cava filter |
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| US20080234722A1 (en) * | 2006-06-14 | 2008-09-25 | Possis Medical, Inc. | Inferior vena cava filter on guidewire |
| CN101843531A (en) * | 2010-05-25 | 2010-09-29 | 天健医疗科技(苏州)有限公司 | Medicament coated thrombus filter |
| CN205054504U (en) * | 2015-07-09 | 2016-03-02 | 张福先 | Recoverable vena cave filter |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108992202A (en) * | 2018-08-14 | 2018-12-14 | 内蒙古工业大学 | A kind of not damaged retrievable vena cava filter |
| CN109984860A (en) * | 2019-01-30 | 2019-07-09 | 张韬 | Intravascular filter |
| CN115670738A (en) * | 2022-12-28 | 2023-02-03 | 北京华脉泰科医疗器械股份有限公司 | Thrombolytic catheter filter and thrombolytic filter combination kit |
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Application publication date: 20180410 |