CN107890361B - Preparation method of knotting-free surgical suture - Google Patents
Preparation method of knotting-free surgical suture Download PDFInfo
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- CN107890361B CN107890361B CN201711114223.0A CN201711114223A CN107890361B CN 107890361 B CN107890361 B CN 107890361B CN 201711114223 A CN201711114223 A CN 201711114223A CN 107890361 B CN107890361 B CN 107890361B
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- surgical suture
- suture
- heavy denier
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- denier yarn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/08—Melt spinning methods
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- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/448—Yarns or threads for use in medical applications
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- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
- D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
- D02J1/06—Imparting irregularity, e.g. slubbing or other non-uniform features, e.g. high- and low-shrinkage or strengthened and weakened sections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The invention relates to a preparation method of a knotting-free surgical suture, which comprises the steps of melt spinning, heating, filament pressing, punching, cooling winding and the like. The surgical suture prepared by the method comprises a first part and a second part which are distributed at intervals, wherein the cross section width of the first part is uniform, the cross section width of the second part is larger than that of the first part, the first end of the second part and the first part are in arc smooth transition, the edge of the second end of the second part is vertical to the axial direction of the surgical suture, and a sawtooth part is arranged between the two ends of the second part; a long-strip-shaped hole is formed in the middle of the inner part of the second part. The surgical suture line disclosed by the invention has the advantages of no knotting, easiness in passing through muscles and low production cost, and can save knotting time in the surgical suture process and relieve the pain of patients.
Description
Technical Field
The invention relates to an operation suture line, in particular to a preparation method of a knotting-free operation suture line.
Background
The traditional operation suture line is a non-absorption line, the wound caused by using the suture line is large in the postoperative suture process, the suture needs to be removed after the wound is healed, the secondary wound is caused, and the recovery time is also long; and the suture line is generally the whole line, need waste a large amount of time to wear the needle and lead wire before the operation, when needing to do the continuous sewing, often need to sew up the back and beat several knots to prevent that the operation suture line from appearing the slip phenomenon. However, due to the limited space of the wound site, this procedure not only adds some complicated steps, but also prolongs the operation time and the anesthesia time, resulting in an increased risk factor for the patient.
In order to reduce knotting and even not knotting and shorten the operation time, the utility model patent with the application number of CN201120279072.6 and the authorization publication number of CN202161363U discloses a tension-reducing operation suture line suitable for a double-ended needle, which is suitable for a double-ended needle structure and comprises a needle body and needle heads distributed at two ends of the needle body. The tension-reducing surgical suture line is formed with barbs with symmetrical structures from the middle to two sides, and the passed tissues bear tension due to the barbs on the surgical suture line during continuous suture, so that the slippage phenomenon of the suture line during continuous suture is prevented. However, the surgical suture is not easy to produce, and because the material of the surgical suture is generally the material of a flexible soft body, the use of the barb structure alone cannot completely replace knotting. Therefore, how to make the surgical suture line not need to be knotted in the suturing process and easy to produce is a technical problem to be solved by the technical personnel in the field.
Disclosure of Invention
In view of the above technical problems in the prior art, the present invention provides a method for preparing a surgical suture, which can produce a surgical suture that does not require knotting during the surgical suture process and is easy to produce.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a preparation method of a knotting-free surgical suture, which comprises the following steps:
step (1), melt spinning: melting a high polymer material for preparing the surgical suture, and preparing a heavy denier yarn by using a melt spinning method;
heating in step (2): uniformly heating the heavy denier yarn wire prepared in the step (1) to enable the heavy denier yarn wire to become soft;
step (3), wire pressing: the heated heavy denier yarn is intermittently extruded through an extruding device, the extruding device comprises a pressure roller and a stress groove, a plurality of protrusions are evenly and intermittently distributed on the pressure roller along the axial direction, the cross section of each protrusion is provided with a first end and a second end, the first end is in a semi-elliptical shape, the second end is in a rectangular shape, a plurality of sawteeth are formed between the first end and the second end, each sawtooth is in a right-angled triangle shape, the right-angle side of each right-angled triangle is close to the second end, the hypotenuse of each right-angled triangle is close to the first end, and the direction of each right-angle side is; the width of the stress groove is not less than the width of the section of the protrusion; the heated heavy denier yarn passes through the middle position of the stressed groove at a constant speed, and the plurality of bulges which are uniformly and discontinuously distributed extrude the heavy denier yarn to ensure that second parts are uniformly distributed on the heavy denier yarn;
and (4) punching: punching the middle position of the second part on the heavy denier yarn by a punching device, wherein the hole is in a long strip shape;
step (5), cooling and winding: and (4) cooling and winding the heavy denier filament yarn obtained in the step (4) to obtain the knotting-free surgical suture.
Preferably, the cross section of the heavy denier filament obtained in step (1) is circular.
Preferably, in the punching in the step (4), the shape of the hole is rectangular or oval.
Preferably, the polymer material used in step (1) is a degradable material, and more preferably, the degradable material is polyglycolide.
Preferably, the anti-inflammatory hemostatic is also added into the raw materials during the melt spinning in the step (1).
In addition, the spacing distance of the plurality of protrusions which are evenly distributed on the pressure roller along the axial direction at intervals can be set according to actual requirements, such as the spacing of sewing needles and the like.
By controlling the shape of the punching die in the punching step (4) and the shape of the protrusion in the wire pressing step (3), the knotting-free surgical suture line can be prepared, and comprises a first part and a second part, wherein the first part and the second part are distributed at intervals, the cross section width of the first part of the surgical suture line is uniform, the cross section width of the second part is larger than that of the first part, the first end of the second part and the first part are in arc smooth transition, the edge of the second end of the second part is perpendicular to the axial direction of the surgical suture line, a saw tooth part is further arranged between the two ends of the second part, the saw tooth part is provided with a plurality of saw teeth with right-angled triangular cross sections, the right-angled edge of each saw tooth is close to the second end of the second part and perpendicular to the axial direction of the surgical suture line, and the oblique edge of each saw tooth is close to the first end; an elongated hole is formed in the second part at the central position inside the second part, the length of the hole is not less than the longitudinal width of the second part, and the width of the hole is not less than the cross-sectional width of the first part.
Meanwhile, the invention also provides a suture method of the knotting-free surgical suture, the prepared knotting-free surgical suture is adopted to suture wounds, when each suture is used for suturing, the suture is provided with the second part, the first end of the second part is in smooth transition, so that the suture can easily pass through muscles under the action of tensile force, and the edge of the second end of the second part is vertical to the axial direction of the surgical suture, and the second part is also provided with the sawtooth part, so that the suture passing through the muscles is not easy to slip; at this time, the suture needle passes through the surface of the muscle and penetrates through the elongated hole of the nearest second part before the muscle when the suture needle is sutured, so that the slippage of the surgical suture line is further prevented, and in this way, the suture of the next needle is performed until the last needle is sutured, and finally the knot is tied. Therefore, each stitch does not need to be knotted in the whole stitching process, and the stitching time is reduced.
Advantageous effects
Compared with the prior art, the invention has the following beneficial effects: the knotting-free surgical suture line provided by the invention does not need to be knotted in the surgical suture process, is easy to produce, can smoothly penetrate through muscles, is not easy to slip, can smoothly lock each needle by utilizing the strip-shaped hole of the second part in the surgical suture line during suture, is not easy to slip, saves knotting time in the needle sewing process, can more quickly finish the suture process, and relieves the pain of patients. Meanwhile, the degradable material is adopted to produce the operation suture, so that the suture can be prevented from being removed, and the pain of a patient is further relieved. And the anti-inflammatory hemostatic is added in the surgical suture, which is beneficial to the rapid healing of the wound.
Drawings
FIG. 1 is a schematic view of a knot-free surgical suture made in accordance with the present invention.
FIG. 2 is a schematic cross-sectional view of a protrusion on a pressure roller according to the present invention.
Reference numerals: 1-a first part; 2-a second part; 3-hole; 4-saw teeth; 5-a first end of the second portion; 6-second end of the second section.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments and the accompanying drawings.
The invention provides a preparation method of an anti-slip surgical suture, which comprises the following steps:
step (1), melt spinning: melting a high polymer material for preparing the surgical suture, and preparing a heavy denier yarn by using a melt spinning method;
heating in step (2): uniformly heating the heavy denier yarn wire prepared in the step (1) to enable the heavy denier yarn wire to become soft;
step (3), wire pressing: the heated heavy denier yarn is intermittently extruded through an extruding device, the extruding device comprises a pressure roller and a stress groove, a plurality of protrusions are evenly and intermittently distributed on the pressure roller along the axial direction, the cross section of each protrusion is provided with a first end and a second end, the first end is in a semi-elliptical shape, the second end is in a rectangular shape, a plurality of sawteeth are formed between the first end and the second end, each sawtooth is in a right-angled triangle shape, the right-angle side of each right-angled triangle is close to the second end, the hypotenuse of each right-angled triangle is close to the first end, and the direction of each right-angle side is; the width of the stress groove is not less than the width of the section of the protrusion; the heated heavy denier yarn passes through the middle position of the stressed groove at a constant speed, and the plurality of bulges which are uniformly and discontinuously distributed extrude the heavy denier yarn to ensure that second parts are uniformly distributed on the heavy denier yarn;
and (4) punching: punching the middle position of the second part on the heavy denier yarn by a punching device, wherein the hole is in a long strip shape;
step (5), cooling and winding: and (4) cooling and winding the heavy denier filament yarn obtained in the step (4) to obtain the knotting-free surgical suture.
Preferably, the cross section of the heavy denier filament obtained in step (1) is circular.
Preferably, in the punching in the step (4), the shape of the hole is rectangular or oval.
Preferably, the polymer material used in step (1) is a degradable material, and more preferably, the degradable material is polyglycolide.
Preferably, the anti-inflammatory hemostatic is also added into the raw materials during the melt spinning in the step (1).
In addition, the spacing distance of the plurality of protrusions which are evenly distributed on the pressure roller along the axial direction at intervals can be set according to actual requirements, such as the spacing of sewing needles and the like.
By controlling the shape of the punching die in the punching step (4) and the shape of the protrusion in the wire pressing step (3), the knotting-free surgical suture line can be prepared, and comprises a first part 1 and a second part 2, wherein the first part 1 and the second part 2 are distributed at intervals, the cross section width of the first part 1 of the surgical suture line is uniform, the cross section width of the second part 2 is larger than that of the first part 1, the first end 5 of the second part is in arc-shaped smooth transition with the first part 1, the edge of the second end 6 of the second part is perpendicular to the axial direction of the surgical suture line, a sawtooth part is arranged between the two ends of the second part, the sawtooth part is provided with a plurality of sawteeth 4 with right-angled triangle sections, the right-angled sides of the sawteeth 4 are close to the second end 6 of the second part and are vertical to the axial direction of the surgical suture, and the hypotenuse sides of the sawteeth 4 are close to the first end 5 of the second part; an elongated hole 3 is formed in the second part 2 at a central position, the length of the hole 3 is not less than the longitudinal width of the second part 2, and the width of the hole 3 is not less than the cross-sectional width of the first part 1. The shape of the aperture 3 is rectangular or oval. The cross-section of the first portion 1 is circular. The operation suture line comprises degradable materials, so that the suture line does not need to be removed after the operation, and the pain of a patient is relieved. The degradable material in the surgical suture is polyglycolide. The surgical suture line also comprises anti-inflammatory and hemostatic drugs for promoting wound healing.
Meanwhile, the invention also provides a suture method of the knotting-free surgical suture, the prepared knotting-free surgical suture is adopted to suture wounds, when each suture is used for suturing, the suture is provided with the second part, the first end of the second part is in smooth transition, so that the suture can easily pass through muscles under the action of tensile force, and the edge of the second end of the second part is vertical to the axial direction of the surgical suture, and the second part is also provided with the sawtooth part, so that the suture passing through the muscles is not easy to slip; at this time, the suture needle passes through the surface of the muscle and penetrates through the elongated hole of the nearest second part before the muscle when the suture needle is sutured, so that the slippage of the surgical suture line is further prevented, and in this way, the suture of the next needle is performed until the last needle is sutured, and finally the knot is tied. Therefore, each stitch does not need to be knotted in the whole stitching process, and the stitching time is reduced.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. A method of making a knot-free surgical suture comprising a first portion and a second portion, the method comprising the steps of:
step (1), melt spinning: melting a high polymer material for preparing the surgical suture, and preparing a heavy denier yarn by using a melt spinning method;
heating in step (2): uniformly heating the heavy denier yarn wire prepared in the step (1) to enable the heavy denier yarn wire to become soft;
step (3), wire pressing: the heated heavy denier yarn is intermittently extruded through an extruding device, the extruding device comprises a pressure roller and a stress groove, a plurality of protrusions are evenly and intermittently distributed on the pressure roller along the axial direction, the cross section of each protrusion is provided with a first end and a second end, the first end is in a semi-elliptical shape, the second end is in a rectangular shape, a plurality of sawteeth are formed between the first end and the second end, each sawtooth is in a right-angled triangle shape, the right-angle side of each right-angled triangle is close to the second end, the hypotenuse of each right-angled triangle is close to the first end, and the direction of each right-angle side is; the width of the stress groove is not less than the width of the section of the protrusion; the heated heavy denier yarn passes through the middle position of the stressed groove at a constant speed, and the plurality of bulges which are uniformly and discontinuously distributed extrude the heavy denier yarn to ensure that second parts are uniformly distributed on the heavy denier yarn;
and (4) punching: punching the middle position of the second part on the heavy denier yarn by a punching device, wherein the hole is in a long strip shape;
step (5), cooling and winding: cooling and winding the heavy denier filament yarn obtained in the step (4) to obtain a knotting-free surgical suture;
when each needle is sutured, the suture thread is provided with the second part, the first end of the second part is in smooth transition, so that the suture thread can easily pass through muscles under the action of tensile force, and the edge of the second end of the second part is vertical to the axial direction of the surgical suture thread and is also provided with a sawtooth part, so that the suture thread passing through the muscles is not easy to slip; at this time, the suture needle passes through the surface of the muscle and penetrates through the elongated hole of the nearest second part before the muscle when the suture needle is sutured, so that the slippage of the surgical suture line is further prevented, and in this way, the suture of the next needle is performed until the last needle is sutured, and finally the knot is tied.
2. The method of making a knot-free surgical suture as claimed in claim 1, characterized in that: the shape of the hole is rectangular or oval.
3. The method of making a knot-free surgical suture as claimed in claim 1, characterized in that: the first portion is circular in cross-section.
4. A method of preparing a knot-free surgical suture as claimed in claim 3, characterized in that: the surgical suture comprises a degradable material.
5. The method of making a knot-free surgical suture as claimed in claim 4, wherein: the degradable material in the surgical suture is polyglycolide.
6. A method of preparing a knot-free surgical suture as claimed in any one of claims 1 to 5, characterized in that: the surgical suture line also comprises an anti-inflammatory hemostatic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711114223.0A CN107890361B (en) | 2017-11-13 | 2017-11-13 | Preparation method of knotting-free surgical suture |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711114223.0A CN107890361B (en) | 2017-11-13 | 2017-11-13 | Preparation method of knotting-free surgical suture |
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| CN107890361A CN107890361A (en) | 2018-04-10 |
| CN107890361B true CN107890361B (en) | 2020-08-11 |
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| KR102053392B1 (en) * | 2018-10-16 | 2019-12-09 | 주식회사 엠베이스 | Method for manufacturing medical suture for improving sexual function |
| CN111481247B (en) * | 2020-04-20 | 2021-04-06 | 广西壮族自治区人民医院 | Stitching instrument for gastrointestinal endoscope and operation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030153947A1 (en) * | 2002-02-14 | 2003-08-14 | Tomoaki Koseki | Sternum suture material and its manufacturing method |
| CA2665209C (en) * | 2006-10-03 | 2016-01-05 | Alure Medical, Inc. | Minimally invasive tissue support |
| MX2010011160A (en) * | 2008-04-15 | 2011-02-22 | Angiotech Pharm Inc | Self-retaining sutures with bi-directional retainers or uni-directional retainers. |
| US8211126B2 (en) * | 2009-09-22 | 2012-07-03 | Jmea Corporation | Tissue repair system |
| US8814904B2 (en) * | 2010-10-26 | 2014-08-26 | Ziptek LLC. | Surgical suture system |
| US20140172012A1 (en) * | 2012-12-13 | 2014-06-19 | Cook Medical Technologies Llc | Vascular closure device suture tension mechanism |
| US9872679B2 (en) * | 2013-02-05 | 2018-01-23 | Ethicon, Inc. | Locally reversible barbed sutures |
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Effective date of registration: 20200715 Address after: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Applicant after: JIANGSU PROVINCE JIANERKANG MADICAL DRESSING CO.,LTD. Address before: 323000 No. 5 101, 33 blocks, Tianning Yicun, Liandu District, Lishui City, Zhejiang Province Applicant before: LISHUI ZHENGMING MACHINERY TECHNOLOGY Co.,Ltd. |
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Address after: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Patentee after: Jianerkang Medical Technology Co.,Ltd. Address before: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Patentee before: Jiangsu jianerkang Medical Technology Co.,Ltd. Address after: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Patentee after: Jiangsu jianerkang Medical Technology Co.,Ltd. Address before: 213200 Jiangsu city of Changzhou province Jintan District Town Industrial Zone jianerkang Road No. 1 Patentee before: JIANGSU PROVINCE JIANERKANG MADICAL DRESSING CO.,LTD. |