CN107868269A - A kind of light proofing infusion apparatus catheter surface method of modifying - Google Patents
A kind of light proofing infusion apparatus catheter surface method of modifying Download PDFInfo
- Publication number
- CN107868269A CN107868269A CN201711311436.2A CN201711311436A CN107868269A CN 107868269 A CN107868269 A CN 107868269A CN 201711311436 A CN201711311436 A CN 201711311436A CN 107868269 A CN107868269 A CN 107868269A
- Authority
- CN
- China
- Prior art keywords
- infusion apparatus
- modifying
- hydrophily
- light
- proofing infusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/16—Chemical modification with polymerisable compounds
- C08J7/18—Chemical modification with polymerisable compounds using wave energy or particle radiation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
- C08F226/10—N-Vinyl-pyrrolidone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of light proofing infusion apparatus catheter surface method of modifying, by being used as the base material of conduit from block polyurethane, then introduces hydrophily lucifuge agent coating to substrate surface, base material is surface-treated so as to realize.By the method for modifying of the present invention, conduit is detected, pipe resistance is not more than 1N, and biocompatibility test is qualified, and cytotoxicity is less than 1 grade, tissue reaction without exception, hemolysis rate ＜ 3%.
Description
Technical field
The present invention relates to a kind of light proofing infusion apparatus catheter surface method of modifying, belong to technical field of medical instruments.
Background technology
Clinically there are many photosensitizers during human body is infused into by infusion pipeline, may be by light
Irradiate and produce the photosensitized reactions such as decomposition, oxidation, so as to cause drug failure, it is also possible to produce noxious material and endanger patient
Health, therefore work out a kind of light proofing infusion apparatus.The lucifuge pipeline of conventional light proofing infusion apparatus is general direct to realize that lucifuge acts on
Lucifuge agent is added in the material, and such a mode can cause decoction to be contacted with lucifuge agent material surface, lucifuge agent be present and enter people
The toxic hazard of body.Also have and squeezed into lucifuge agent in material using the extrusion moulding technology of double-layer coextrusion, but such a mode produces
Complex process, bilayer thickness are difficult to hold, low production efficiency.
The content of the invention
For above-mentioned prior art, it is an object of the invention to provide light proofing infusion apparatus conduit a kind of simple to operate and safe
Surface modifying method.
The technical solution adopted by the present invention is：Light proofing infusion apparatus catheter surface method of modifying, it is characterised in that pass through selection
Base material of the block polyurethane as conduit, hydrophily lucifuge agent coating is then introduced to substrate surface, base material is entered so as to realize
Row surface treatment.
Preferably, above-mentioned hydrophily lucifuge oxidant layer is introduced using surface grafting technology or photochemical immobilization.
Preferably, above-mentioned surface grafting technology is specifically and first passes through polyethylene glycol to keep away in the introducing of block polyurethane substrate surface
Photo etching, then directly trigger hydrophilic monomer NVP and acrylamide by ultraviolet light in block polyurethane table
Face carries out graft reaction, forms hydrophilic layer.
Preferably, above-mentioned photochemical immobilization is specifically first to add appropriate lucifuge agent using hydrophilic copolymers as base-material,
Hydrophily lucifuge agent coating is formed, then utilizes ultraviolet or visibility region（300-800nm）Light is by hydrophily lucifuge agent coating
It is coupled to block polyurethane surface.
Preferably, above-mentioned block polyurethane has the micro phase separation structure of soft segment and hard section.
The lucifuge agent of the present invention, block polyurethane are from buying on the market.
Compared with prior art, the beneficial effect possessed is：1st, base material is used as using block polyurethane, there is provided excellent blood
Liquid phase capacitive, while also provide excellent comprehensive mechanical performance；2nd, the agent of hydrophily lucifuge is introduced using photochemical immobilization to apply
Layer, effectively increases adhesive force of the lucifuge agent on base material, stability is also stronger, while coating uniform can be made to be covered in base material table
Face, significantly improve greasy property；3rd, technique is simple and thoroughly to solve the intravascular infection of venous detaining needle, blood coagulation etc. hidden safely
Suffer from, improve the security of clinical intervention drug treatment.By the method for modifying of the present invention, conduit is detected, pipe resistance
No more than 1N, biocompatibility test is qualified, and cytotoxicity is less than 1 grade, tissue reaction without exception, hemolysis rate ＜ 3%.
Embodiment
In conjunction with specific embodiment, the invention will be further elaborated.It is worth noting that, the skill based on the present invention
Art scheme, the improvement project of creative work is not being made, the scope of protection of the invention all should be belonged to.The application is not specifically mentioned
Technology and technical parameter use technology of the prior art and technical parameter.
Embodiment one
The light proofing infusion apparatus catheter surface method of modifying of the present invention, by being used as the base material of conduit from block polyurethane, then
Hydrophily lucifuge agent coating is introduced to substrate surface using surface grafting technology, base material is surface-treated so as to realize, had
Body is to first pass through polyethylene glycol to introduce lucifuge agent in block polyurethane substrate surface, then directly triggers hydrophily by ultraviolet light
Monomer N-vinyl pyrrolidones and acrylamide carry out graft reaction on block polyurethane surface, form hydrophilic layer.
Block polyurethane has the micro phase separation structure of soft segment and hard section.
Embodiment two
Light proofing infusion apparatus catheter surface method of modifying, by being used as the base material of conduit from block polyurethane, then using photochemical
Learn fixation and introduce hydrophily lucifuge agent coating to the substrate surface by pretreatment, base material is carried out at surface so as to realize
Reason, it is specifically that appropriate lucifuge agent is first added using hydrophilic copolymers as base-material, forms hydrophily lucifuge agent coating, Ran Houli
With ultraviolet or visibility region（300-800nm）Hydrophily lucifuge agent coating is coupled to block polyurethane surface by light.Block gathers
Urethane has the micro phase separation structure of soft segment and hard section.
Claims (5)
1. a kind of light proofing infusion apparatus catheter surface method of modifying, it is characterised in that by being used as conduit from block polyurethane
Base material, hydrophily lucifuge agent coating is then introduced to substrate surface, base material is surface-treated so as to realize.
2. light proofing infusion apparatus catheter surface method of modifying according to claim 1, it is characterised in that above-mentioned hydrophily lucifuge
Oxidant layer is introduced using surface grafting technology or photochemical immobilization.
3. light proofing infusion apparatus catheter surface method of modifying according to claim 2, it is characterised in that above-mentioned surface grafting skill
Art is specifically to first pass through polyethylene glycol to introduce lucifuge agent in block polyurethane substrate surface, then directly triggers parent by ultraviolet light
Aqueous monomers NVP and acrylamide carry out graft reaction on block polyurethane surface, form hydrophilic layer.
4. light proofing infusion apparatus catheter surface method of modifying according to claim 2, it is characterised in that above-mentioned photochemical fixation
Method is specifically that appropriate lucifuge agent is first added using hydrophilic copolymers as base-material, forms hydrophily lucifuge agent coating, then utilizes
Ultraviolet or visibility region（300-800nm）Hydrophily lucifuge agent coating is coupled to block polyurethane surface by light.
5. the light proofing infusion apparatus catheter surface method of modifying according to claim 1 or 2 or 3 or 4, it is characterised in that above-mentioned
Block polyurethane has the micro phase separation structure of soft segment and hard section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711311436.2A CN107868269A (en) | 2017-12-12 | 2017-12-12 | A kind of light proofing infusion apparatus catheter surface method of modifying |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711311436.2A CN107868269A (en) | 2017-12-12 | 2017-12-12 | A kind of light proofing infusion apparatus catheter surface method of modifying |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107868269A true CN107868269A (en) | 2018-04-03 |
Family
ID=61755471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711311436.2A Pending CN107868269A (en) | 2017-12-12 | 2017-12-12 | A kind of light proofing infusion apparatus catheter surface method of modifying |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107868269A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2566548B2 (en) * | 1990-10-05 | 1996-12-25 | ユニヴァーシティ オブ フロリダ | Surface-modified surgical instruments, instruments, implants, contact lenses and the like |
| CN2417876Y (en) * | 2000-04-22 | 2001-02-07 | 宋凤兰 | Antilight venous transfusion device |
| CN102357265A (en) * | 2011-07-29 | 2012-02-22 | 中山大学 | Surface modification polyurethane central venous catheter and preparation method thereof |
| CN103302012A (en) * | 2012-03-15 | 2013-09-18 | 丘梅丽 | Coloring technology for outer surfaces of catheter and drip chamber of light resistant infusion apparatus |
| CN203989218U (en) * | 2014-01-09 | 2014-12-10 | 江苏苏云医疗器材有限公司 | A kind of light proofing infusion apparatus |
| CN106540336A (en) * | 2016-11-29 | 2017-03-29 | 中国科学院兰州化学物理研究所 | A kind of hydrophilic modifying coating on medical introducing duct surface |
-
2017
- 2017-12-12 CN CN201711311436.2A patent/CN107868269A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2566548B2 (en) * | 1990-10-05 | 1996-12-25 | ユニヴァーシティ オブ フロリダ | Surface-modified surgical instruments, instruments, implants, contact lenses and the like |
| CN2417876Y (en) * | 2000-04-22 | 2001-02-07 | 宋凤兰 | Antilight venous transfusion device |
| CN102357265A (en) * | 2011-07-29 | 2012-02-22 | 中山大学 | Surface modification polyurethane central venous catheter and preparation method thereof |
| CN103302012A (en) * | 2012-03-15 | 2013-09-18 | 丘梅丽 | Coloring technology for outer surfaces of catheter and drip chamber of light resistant infusion apparatus |
| CN203989218U (en) * | 2014-01-09 | 2014-12-10 | 江苏苏云医疗器材有限公司 | A kind of light proofing infusion apparatus |
| CN106540336A (en) * | 2016-11-29 | 2017-03-29 | 中国科学院兰州化学物理研究所 | A kind of hydrophilic modifying coating on medical introducing duct surface |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180403 |