CN107854681A - 一种抗炎组合物及其制备方法 - Google Patents
一种抗炎组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种抗炎组合物及其制备方法，包括如下重量份的原料：大蒜皮提取物10‑15份、柚子皮提取物5‑10份、牡丹花提取物8‑12份、生姜汁3‑5份和薄荷脑0.01‑0.05份。本发明有效了将大蒜皮和柚子皮收集起来合理利用，避免了资源的浪费；辅以牡丹花提取液和生姜汁，在提升香气的同时，抗炎、增强免疫调节功能，且安全、无抗药性。采用此组合物制备的膏状物具有很好的抗炎、抑菌效果。
Description
技术领域
本发明属于抗炎用品技术领域，具体涉及一种抗炎组合物及其制备方法。
背景技术
随着生活水平的提高，人们对组合物的要求不再仅限于解渴、清凉，还要求具有较高的营养价值。
大蒜各部位含有多种活性成分，被誉为“地里长出来的抗生素”。诸多研究表明，大蒜具有抗菌消炎、防治癌症、抗氧化、增强免疫力等生理活性，已广泛应用于医药、食品、化妆品等领域。
柚为芸香科，在我国广东、广西及福建有大量种植，其果肉味酸可口，为大众所喜爱。柚皮占整个柚子的43％～48％，含有如黄酮类化合物、挥发油、柠檬苦素类化合物及天然色素等多种非营养性生理活性成分，对人体健康非常有益，并具有抗炎、抗氧化、防紫外线及抗过敏等作用。
然而，生活中大蒜皮及柚皮多被当作废弃物直接丢掉，造成了资源的浪费。
发明内容
本发明旨在至少解决现有技术中存在的技术问题之一。为此，本发明提供一种抗炎组合物及其制备方法和应用，目的是便于回收利用大蒜皮及柚子皮，制备的组合物外用对皮肤有抗炎、抑菌效果。
为了实现上述目的，本发明采取的技术方案为：
一种抗炎组合物，包括如下重量份的原料：
大蒜皮提取物10-15份、柚子皮提取物5-10份、牡丹花提取物8-12份、生姜汁3-5份和薄荷脑0.01-0.05份。
优选的，所述原料还包括椰子油0.5-1份、薰衣草浸泡油0.5-1份和乳化剂0.2-0.8份。
所述原料还包括勿忘我花提取物1-2份。
所述原料还包括榆耳煎煮液1-3份。
所述抗炎组合物的制备方法，包括如下步骤：
(1)取大蒜皮经清洗、干燥后粉碎成粉末，在85-90℃下用质量分数为65-70％乙醇回流提取，提取液离心分离浓缩后得大蒜皮提取物；
(2)取柚子皮采用超声波浸提法得到柚子皮提取物；
(3)取牡丹花用质量分数为60-70％乙醇浸泡1-3h，减压提取两次，第一次30-50min，第二次20-30min，减压提取的压力为60-80mbar，减压提取的温度是40-60℃，提取液过滤减压浓缩后得牡丹花提取物；
(4)取生姜压榨过滤取汁液得生姜汁；
(5)将大蒜皮提取物10-15份、柚子皮提取物5-10份、牡丹花提取物8-12份、生姜汁3-5份和薄荷脑0.01-0.05份混合于容器中，加入柠檬酸将溶液pH调至6-6.5，即得。调节至弱酸性，能够显著提高其抗炎效果，并且组合物不易出现分层化。
所述步骤(5)的容器中还加入有椰子油0.5-1份、薰衣草浸泡油0.5-1份和乳化剂0.2-0.8份，容器密闭并搅拌加热至80-90℃，冷却后得膏状物。
所述步骤(5)的容器中还加入有勿忘我提取物1-2份，勿忘我提取物的制备方法是取勿忘我干花回流提取三次，第一次加10-12倍量的水，提取0.5-2h；第二次加8-10倍水，提取0.5-2h；第三次加6-8倍水，提取0.5-2h；每次三层纱布过滤，合并滤液，将滤液减压浓缩至勿忘我干花重量的1-5倍g/ml，即得。
所述步骤(5)中还加入有榆耳煎煮液1-3份，榆耳煎煮液是取榆耳加水煎煮2-3次，每次加6-10倍水煎煮30-60min，合并煎煮液，并澄清处理后得到。
所述薰衣草浸泡油的制备方法是取薰衣草干花加入8-10倍油茶籽油使其完全浸没，先浸泡8-24h，然后置于40-60℃超声仪中超声提取20-60min，用双层纱布过滤，取滤液即得。
牡丹花主要的活性成分为丹皮酚和芍药苷，具有镇静、抗炎、解热、抗过敏、增强免疫调节、抑制多种致病细菌繁殖等药理作用，而且丹皮酚对口腔刺激小，无耐药性，能够保护口腔内的益生菌。此外，牡丹花中含有丰富的天然香味物质。
勿忘我富含维生素C，具有滋阴补肾，清肝明目，养颜美容，补血养血，并能促经机体新陈代谢，延缓细胞衰老，提高免疫能力，抗病毒，抗癌防癌之功效，还可排除赘肉，减缓皱纹及黑斑的产生，美白肌肤。
榆耳含有一定的天然药性成分，药理试验表明，其代谢产物具有抗产气杆菌、绿脓杆菌、肠杆菌、大肠杆菌及金黄色葡萄杆菌等活性。能补益、和中、固肾气，利尿道，用于补虚、疗痔、泻痢(对肠炎沙门杆菌的抑制作用最为明显)等肠胃系统疾病。
柚子皮可以抑制金黄色葡萄球菌、沙门氏菌的生长；具有防治胃溃疡、降血脂及血胆固醇，抗炎、解痉、镇痛等功能。
椰子油含游离脂肪酸，亚油酸，棕榈酸，羊脂酸，脂蜡酸，羊蜡酸，油酸，月桂酸等，可以提拉细胞间的紧密度，强化毛孔的收缩能力，帮助去除死皮细胞的外层，恢复受损皮肤，使皮肤的表皮真皮交界处更为健康、光滑，可生成新的皮肤细胞。对厚的、粗的、鳞屑的、干燥的、表面不平滑的、损害的、肤色不均匀或其它真菌引起的皮肤病甚至病变感染等具有明显疗效，能去除死皮细胞，改善皮肤状况。
薰衣草称为“香草之后”，适合任何皮肤，促进细胞再生、加速伤口愈合，其香气能醒脑明目，使人舒适，还能驱除蚊蝇。薰衣草浸泡油是用油茶籽油浸提薰衣草的有效成分。薰衣草浸泡油可抑制细菌的生长，避免引发皮肤感染，安抚皮肤，平衡皮肤油脂分泌过多，止痛、抗忧郁、消毒、杀菌、解除充血肿胀及驱虫、镇定和恢复健康。
抗炎组合物涂覆于皮肤出现肿痛及瘙痒处，早晚各一次，皮肤止痒消肿效果明显。统计有73人使用此方法涂覆患处，68人均有明显疗效。
本发明的有益效果：本发明有效了将大蒜皮和柚子皮收集起来合理利用，避免了资源的浪费；辅以牡丹花提取液和生姜汁，在提升香气的同时，抗炎、增强免疫调节功能，且安全、无抗药性。采用此组合物制备的膏状物具有很好的抗炎、抑菌效果。
具体实施方式
下面通过对实施例的描述，对本发明的具体实施方式作进一步详细的说明，目的是帮助本领域的技术人员对本发明的构思、技术方案有更完整、准确和深入的理解，并有助于其实施。
实施例1
一种抗炎组合物，包括如下重量份的原料：
大蒜皮提取物10份、柚子皮提取物6份、牡丹花提取物8份、生姜汁3份和薄荷脑0.01份。
该抗炎组合物的制备方法，包括如下步骤：
(1)取大蒜皮经清洗、干燥后粉碎成粉末，在85℃下用质量分数为70％乙醇回流提取，提取液离心分离浓缩后得大蒜皮提取物；
(2)取柚子皮采用超声波浸提法得到柚子皮提取物；
(3)取牡丹花用质量分数为70％乙醇浸泡1h，减压提取两次，第一次40min，第二次30min，减压提取的压力为70mbar，减压提取的温度是50℃，提取液过滤减压浓缩后得牡丹花提取物；
(4)取生姜压榨过滤取汁液得生姜汁；
(5)将大蒜皮提取物10份、柚子皮提取物6份、牡丹花提取物8份、生姜汁3份和薄荷脑0.01份混合于容器中，加入柠檬酸将溶液pH调至6.5，即得。
实施例2
一种抗炎组合物，包括如下重量份的原料：
大蒜皮提取物13份、柚子皮提取物10份、牡丹花提取物10份、生姜汁5份、薄荷脑0.03份、椰子油0.5份、薰衣草浸泡油0.5份和乳化剂0.3份。
该抗炎组合物的制备方法，包括如下步骤：
(1)取大蒜皮经清洗、干燥后粉碎成粉末，在90℃下用质量分数为70％乙醇回流提取，提取液离心分离浓缩后得大蒜皮提取物；
(2)取柚子皮采用超声波浸提法得到柚子皮提取物；
(3)取牡丹花用质量分数为70％乙醇浸泡1h，减压提取两次，第一次40min，第二次30min，减压提取的压力为70mbar，减压提取的温度是50℃，提取液过滤减压浓缩后得牡丹花提取物；
(4)取生姜压榨过滤取汁液得生姜汁；
(5)将大蒜皮提取物13份、柚子皮提取物10份、牡丹花提取物10份、生姜汁5份、薄荷脑0.03份、椰子油0.5份、薰衣草浸泡油0.5份和乳化剂0.3份混合于容器中，容器密闭并搅拌加热至80-90℃，加入柠檬酸将溶液pH调至6.3，冷却后即得。
实施例3
一种抗炎组合物，包括如下重量份的原料：
大蒜皮提取物15份、柚子皮提取物12份、牡丹花提取物12份、生姜汁5份、薄荷脑0.03份、椰子油0.5份、薰衣草浸泡油0.5份、乳化剂0.3份和勿忘我花提取物1份。
该抗炎组合物的制备方法，包括如下步骤：
(1)取大蒜皮经清洗、干燥后粉碎成粉末，在90℃下用质量分数为70％乙醇回流提取，提取液离心分离浓缩后得大蒜皮提取物；
(2)取柚子皮采用超声波浸提法得到柚子皮提取物；
(3)取牡丹花用质量分数为70％乙醇浸泡1h，减压提取两次，第一次40min，第二次30min，减压提取的压力为70mbar，减压提取的温度是50℃，提取液过滤减压浓缩后得牡丹花提取物；
(4)取生姜压榨过滤取汁液得生姜汁；
(5)取勿忘我干花回流提取三次，第一次加10倍量的水，提取1h；第二次加8倍水，提取1h；第三次加6-8倍水，提取0.5h；每次三层纱布过滤，合并滤液，将滤液减压浓缩至勿忘我干花重量的3倍g/ml，即得；
(6)将大蒜皮提取物15份、柚子皮提取物12份、牡丹花提取物12份、生姜汁5份、薄荷脑0.03份、椰子油0.5份、薰衣草浸泡油0.5份、乳化剂0.3份和勿忘我花提取物1份混合于容器中，容器密闭并搅拌加热至80-90℃，加入柠檬酸将溶液pH调至6.4，冷却后即得。
实施例4
一种抗炎组合物，包括如下重量份的原料：
大蒜皮提取物15份、柚子皮提取物12份、牡丹花提取物12份、生姜汁5份、薄荷脑0.03份、椰子油0.5份、薰衣草浸泡油0.5份、乳化剂0.3份、勿忘我花提取物2份和榆耳煎煮液2份。
该抗炎组合物的制备方法，包括如下步骤：
(1)取大蒜皮经清洗、干燥后粉碎成粉末，在90℃下用质量分数为70％乙醇回流提取，提取液离心分离浓缩后得大蒜皮提取物；
(2)取柚子皮采用超声波浸提法得到柚子皮提取物；
(3)取牡丹花用质量分数为70％乙醇浸泡1h，减压提取两次，第一次40min，第二次30min，减压提取的压力为70mbar，减压提取的温度是50℃，提取液过滤减压浓缩后得牡丹花提取物；
(4)取生姜压榨过滤取汁液得生姜汁；
(5)取勿忘我干花回流提取三次，第一次加10倍量的水，提取1h；第二次加8倍水，提取1h；第三次加6-8倍水，提取0.5h；每次三层纱布过滤，合并滤液，将滤液减压浓缩至勿忘我干花重量的3倍g/ml，即得；
(6)取榆耳加水煎煮2-3次，每次加8倍水煎煮40min，合并煎煮液，并澄清处理后得到；
(7)将大蒜皮提取物15份、柚子皮提取物12份、牡丹花提取物12份、生姜汁5份、薄荷脑0.03份、椰子油0.5份、薰衣草浸泡油0.5份、乳化剂0.3份、勿忘我花提取物2份和榆耳煎煮液2份混合于容器中，容器密闭并搅拌加热至80-90℃，加入柠檬酸将溶液pH调至6.3左右，冷却后即得。
实施例5
本实施例与实施例4的不同点在于，制备方法中未加入柠檬酸调节pH。
抗炎作用评价
取健康小鼠60只，随机分成6组，即生理盐水组、1号样品组(实施例1所得组合物)、2号样品组(实施例2所得组合物)、3号样品组(实施例3所得组合物)、4号样品组(实施例4所得组合物)和5号样品组(实施例5所得组合物)。实验室每只小鼠分别用二甲苯0.03ml/只涂左耳致炎，右耳不处理做空白对照。涂抹二甲苯20min后，各组小鼠左耳内外两面分别均匀涂抹各组授试样品。1h后处死小鼠，在小鼠左右两耳相同位置取耳片，立即用电子天平称重，计算左右耳重量差值(肿胀度)及抑制率。结果表明：1-5号样品组均能是二甲苯所致的小鼠极性炎症肿胀耳廓重量显著减轻，表明对极性炎症具有明显的抗炎作用。相比较而言，实施例5的抗炎效果相对较差。
以上对本发明进行了示例性描述。显然，本发明具体实现并不受上述方式的限制。只要是采用了本发明的方法构思和技术方案进行的各种非实质性的改进；或未经改进，将本发明的上述构思和技术方案直接应用于其它场合的，均在本发明的保护范围之内。
Claims (9)
1.一种抗炎组合物，其特征在于，包括如下重量份的原料：
大蒜皮提取物10-15份、柚子皮提取物5-10份、牡丹花提取物8-12份、生姜汁3-5份和薄荷脑0.01-0.05份。
2.根据权利要求1所述抗炎组合物，其特征在于，所述原料还包括椰子油0.5-1、薰衣草浸泡油0.5-1份和乳化剂0.2-0.8份。
3.根据权利要求1所述抗炎组合物，其特征在于，所述原料还包括勿忘我花提取物1-2份。
4.根据权利要求1所述抗炎组合物，其特征在于，所述原料还包括榆耳煎煮液1-3份。
5.根据权利要求1所述抗炎组合物的制备方法，其特征在于，包括如下步骤：
(1)取大蒜皮经清洗、干燥后粉碎成粉末，在85-90℃下用质量分数为65-70％乙醇回流提取，提取液离心分离浓缩后得大蒜皮提取物；
(2)取柚子皮采用超声波浸提法得到柚子皮提取物；
(3)取牡丹花用质量分数为60-70％乙醇浸泡1-3h，减压提取两次，第一次30-50min，第二次20-30min，减压提取的压力为60-80mbar，减压提取的温度是40-60℃，提取液过滤减压浓缩后得牡丹花提取物；
(4)取生姜压榨过滤取汁液得生姜汁；
(5)将大蒜皮提取物10-15份、柚子皮提取物5-10份、牡丹花提取物8-12份、生姜汁3-5份和薄荷脑0.01-0.05份混合于容器中，加入柠檬酸将溶液pH调至6-6.5，即得。
6.根据权利要求5所述抗炎组合物的制备方法，其特征在于，所述步骤(5)的容器中还加入有椰子油0.5-1份、薰衣草浸泡油0.5-1份和乳化剂0.2-0.8份，容器密闭并搅拌加热至80-90℃，冷却后得膏状物。
7.根据权利要求5所述抗炎组合物的制备方法，其特征在于，所述步骤(5)的容器中还加入有勿忘我提取物1-2份，勿忘我提取物的制备方法是取勿忘我干花回流提取三次，第一次加10-12倍量的水，提取0.5-2h；第二次加8-10倍水，提取0.5-2h；第三次加6-8倍水，提取0.5-2h；每次三层纱布过滤，合并滤液，将滤液减压浓缩至勿忘我干花重量的1-5倍g/ml，即得。
8.根据权利要求5所述抗炎组合物的制备方法，其特征在于，所述步骤(5)中还加入有榆耳煎煮液1-3份，榆耳煎煮液是取榆耳加水煎煮2-3次，每次加6-10倍水煎煮30-60min，合并煎煮液，并澄清处理后得到。
9.根据权利要求5所述抗炎组合物的制备方法，其特征在于，所述薰衣草浸泡油的制备方法是取薰衣草干花加入8-10倍油茶籽油使其完全浸没，先浸泡8-24h，然后置于40-60℃超声仪中超声提取20-60min，用双层纱布过滤，取滤液即得。
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