CN107854632A - 一种治疗消化性溃疡的中药缓释剂 - Google Patents
一种治疗消化性溃疡的中药缓释剂 Download PDFInfo
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Abstract
本发明属于中药制备技术领域,具体公开一种治疗消化性溃疡的中药缓释剂,包括以下原料,且各项原料的重量份数为:木香10~20份、薏苡仁10~20份、鸡内金10~20份、黄连10~15、甘草10~15份、铁树叶10~20份、山楂10~20份、海螵蛸15~25份、蒲公英10~20份、三七10~20份、陈皮20~30份、佛手5~15份、金橘根5~10份、羟丙基甲基纤维素35~75份、丙烯酸树脂35~75份、填充料50~100份、硬脂酸镁3.5~7.5份。本发明还提供了治疗消化性溃疡的中药缓释剂的制造方法。本发明提供的治疗消化性溃疡的中药缓释剂起效快,作用时间长,易吸收,疗效好。
Description
发明领域
本发明属于中药制备技术领域,具体地说是涉及一种治疗消化性溃疡的中药缓释剂。
背景技术
胃肠道是人体最大的免疫器官,也是人体最大的排毒器官。消化性溃疡是一种常见的消化道疾病,可发生于食管、胃或十二指肠,也可发生于胃-空肠吻合口附近或含有胃黏膜的Meckel憩室内,原本消化食物的胃酸(盐酸)和胃蛋白酶(酶的一种)却消化了自身的胃壁和十二指肠壁,从而损伤黏膜组织,这是引发消化性溃疡的主要原因。因为胃溃疡和十二指肠溃疡最常见,故一般所谓的消化性溃疡是指胃溃疡和十二指肠溃疡。
中医理论认为:胃为六腑之一,具有受纳腐熟水谷的生理功能。脾胃是人体五脏六腑气机升降的枢纽,也是人体气血生化之源和赖以生存的“水谷之海”。历来有“脾胃为后天之本”的说法,脾胃居中土,是脏腑的中心,脾胃有病极易影响其他脏腑。
目前治疗消化性溃疡的中药也很多,但大多起效慢,作用时间短,吸收效果差,疗效不够好。
发明内容
为解决上述技术问题,本发明提供了一种治疗消化性溃疡的中药缓释剂。
为达到上述目的,本发明所采取的技术方案为:
一种治疗消化性溃疡的中药缓释剂,包括以下原料,且各项原料的重量份数为:木香10~20份、薏苡仁10~20份、鸡内金10~20份、黄连10~15份、甘草10~15份、铁树叶10~20份、山楂10~20份、海螵蛸15~25份、蒲公英10~20份、三七10~20份、陈皮20~30份、佛手5~15份、金橘根5~10份、羟丙基甲基纤维素35~75份、丙烯酸树脂35~75份、填充料50~100份、硬脂酸镁3.5~7.5份。
优选地,在本发明的较佳实施例中,所述填充料包括糊精、蔗糖、乳糖之一或两种以上的混合物。
另外,本发明还提供了一种治疗消化性溃疡的中药缓释剂的制造方法,包括以下步骤:
(1)将所述木香、所述薏苡仁、所述鸡内金、所述黄连、所述甘草、所述铁树叶、所述山楂、所述海螵蛸、所述蒲公英、所述三七、所述陈皮、所述佛手、所述金橘根先经过水提醇沉,将乙醇液过滤,滤液经大孔吸附树脂AB-8处理,用盐酸液洗脱,收集最后洗脱液,浓缩干燥后得干膏备用;
(2)将所述填料加水制成饱和溶液,加入所述干膏,充分研磨至成糊状物,40~60℃干燥,即得包合物;
(3)将所述羟丙基甲基纤维素及丙烯酸树脂作为骨架材料,与所述包合物混匀后制成软材;
(4)将步骤(3)得到的软材低温干燥,粉碎得细粉,以95%乙醇为润湿剂制粒,低温干燥,整粒;
(5)将上述干燥颗粒与硬脂酸镁加入三维混合机混合,压片,分装。
优选地,在本发明的较佳实施例中,步骤(2)中所述填充料与所述干膏的重量比为1:1。
优选地,在本发明的较佳实施例中,步骤(3)中还加入0.5~2份聚乙烯吡络烷酮作为粘合剂。
优选地,在本发明的较佳实施例中,步骤(4)中所述细粉粒度为60~100目。
优选地,在本发明的较佳实施例中,所述中药缓释剂可以为片剂、胶囊剂、颗粒剂。
写上消化性溃疡的治疗原则及治法,并详细描述组合物的君臣佐使关系。
本发明的有益效果:
本发明提供的治疗消化性溃疡的中药缓释剂起效快,作用时间长,易吸收,疗效好。本发明通过对中药的微粒化,明显增加其在胃肠中的溶解度,而增强吸收;本发明可明显提高了传统中药的治疗效果,延长了作用时间,提高生物利用度,减少药量,节约中药资源,降低中药的毒副作用;本发明适用于各种人群,携带、服用方便。
具体实施方式
下面结合具体实施例对本发明所述技术方案作进一步的说明。
以下实施例中木香、薏苡仁、鸡内金、黄连、甘草、铁树叶、山楂、海螵蛸、蒲公英、三七、陈皮、佛手和金橘根来自于亳州市清逸中药材科技有限公司;
羟丙基甲基纤维素、糊精、硬脂酸镁和丙烯酸树脂来自于西安天正药用辅料有限公司。
实施例1:
本发明的实施例1提供了一种治疗消化性溃疡的中药缓释剂,包括以下原料,且各项原料的重量份数为:木香10份、薏苡仁10份、鸡内金10份、黄连10份、甘草10份、铁树叶10份、山楂10份、海螵蛸15份、蒲公英10份、三七10份、陈皮20份、佛手5份、金橘根5份、羟丙基甲基纤维素35份、丙烯酸树脂35份、糊精50份、硬脂酸镁3.5份。
另外,本实施例还提供了一种治疗消化性溃疡的中药缓释剂的制造方法,包括以下步骤:
(1)将木香、薏苡仁、鸡内金、黄连、甘草、铁树叶、山楂、海螵蛸、蒲公英、三七、陈皮、佛手、金橘根先经过水提醇沉,将乙醇液过滤,滤液经大孔吸附树脂AB-8处理,用盐酸液洗脱,收集最后洗脱液,浓缩干燥后得干膏备用;
(2)将填料加水制成饱和溶液,加入干膏,填料与干膏的重量比为1:1,充分研磨至成糊状物,40℃干燥,即得包合物;
(3)将羟丙基甲基纤维素及丙烯酸树脂作为骨架材料,继续加入0.5份聚乙烯吡络烷酮作为粘合剂,与包合物混匀后制成软材;
(4)将步骤(3)得到的软材低温干燥,粉碎至粒度为60目细粉,以95%乙醇为润湿剂制粒,低温干燥,整粒;
(5)将上述干燥颗粒与硬脂酸镁加入三维混合机混合,压片,分装。
实施例2:
本发明的实施例2提供了一种治疗消化性溃疡的中药缓释剂,包括以下原料,且各项原料的重量份数为:木香20份、薏苡仁20份、鸡内金20份、黄连15份、甘草15份、铁树叶20份、山楂20份、海螵蛸25份、蒲公英20份、三七20份、陈皮30份、佛手15份、金橘根10份、羟丙基甲基纤维素75份、丙烯酸树脂75份、蔗糖100份、硬脂酸镁7.5份。
另外,本实施例还提供了一种治疗消化性溃疡的中药缓释剂的制造方法,包括以下步骤:
(1)将木香、薏苡仁、鸡内金、黄连、甘草、铁树叶、山楂、海螵蛸、蒲公英、三七、陈皮、佛手、金橘根先经过水提醇沉,将乙醇液过滤,滤液经大孔吸附树脂AB-8处理,用盐酸液洗脱,收集最后洗脱液,浓缩干燥后得干膏备用;
(2)将填料加水制成饱和溶液,加入干膏,填料与干膏的重量比为1:1,充分研磨至成糊状物,60℃干燥,即得包合物;
(3)将羟丙基甲基纤维素及丙烯酸树脂作为骨架材料,继续加入2份聚乙烯吡络烷酮作为粘合剂,与包合物混匀后制成软材;
(4)将步骤(3)得到的软材低温干燥,粉碎至粒度为100目细粉,以95%乙醇为润湿剂制粒,低温干燥,整粒;
(5)将上述干燥颗粒与硬脂酸镁加入三维混合机混合,压片,分装。
实施例3:
本发明的实施例3提供了一种治疗消化性溃疡的中药缓释剂,包括以下原料,且各项原料的重量份数为:木香15份、薏苡仁15份、鸡内金15份、黄连12份、甘草12份、铁树叶15份、山楂15份、海螵蛸20份、蒲公英15份、三七15份、陈皮25份、佛手10份、金橘根7.5份、羟丙基甲基纤维素55份、丙烯酸树脂55份、糊精75份、硬脂酸镁5.5份。
另外,本实施例还提供了一种治疗消化性溃疡的中药缓释剂的制造方法,包括以下步骤:
(1)将所述木香、所述薏苡仁、所述鸡内金、所述黄连、所述甘草、所述铁树叶、所述山楂、所述海螵蛸、所述蒲公英、所述三七、所述陈皮、所述佛手、所述金橘根先经过水提醇沉,将乙醇液过滤,滤液经大孔吸附树脂AB-8处理,用盐酸液洗脱,收集最后洗脱液,浓缩干燥后得干膏备用;
(2)将填料加水制成饱和溶液,加入干膏,填料与干膏的重量比为1:1,充分研磨至成糊状物,50℃干燥,即得包合物;
(3)将羟丙基甲基纤维素及丙烯酸树脂作为骨架材料,继续加入1.2份聚乙烯吡络烷酮作为粘合剂,与包合物混匀后制成软材;
(4)将步骤(3)得到的软材低温干燥,粉碎至粒度为80目细粉,以95%乙醇为润湿剂制粒,低温干燥,整粒;
(5)将上述干燥颗粒与硬脂酸镁加入三维混合机混合,压片,分装。
选择200例病人,年龄在25-55之间,随机分为4组进行测试,分别使用实施例1-3制备的中药缓释剂,传统中药制剂为对照组,对所有患者进行观察及胃镜检查。
传统中药制剂具体指的是何种制剂,成分是什么?
疗效表示:本组病例以临床症状消失、镜检基本正常为治愈;临床症状基本消失和大部分消失、镜检好转为有效;临床症状无明显好转、镜检无变化为无效。
服用方法:每天早晚各服用一次,经3个疗程的治疗(10天为一个疗程)。
表1:疗效结果
组别 | 治愈 | 有效 | 无效 | 总有效率 |
实施例1 | 16 | 30 | 4 | 92% |
实施例2 | 13 | 32 | 5 | 90% |
实施例3 | 18 | 29 | 3 | 94% |
对照组 | 13 | 25 | 12 | 76% |
以本发明制得的治疗消化性溃疡的中药缓释剂作用时间长,起效快,疗效好,治愈率更高。
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (7)
1.一种治疗消化性溃疡的中药缓释剂,其特征在于,包括以下原料,且各项原料的重量份数为:木香10~20份、薏苡仁10~20份、鸡内金10~20份、黄连10~15份、甘草10~15份、铁树叶10~20份、山楂10~20份、海螵蛸15~25份、蒲公英10~20份、三七10~20份、陈皮20~30份、佛手5~15份、金橘根5~10份、羟丙基甲基纤维素35~75份、丙烯酸树脂35~75份、填充料50~100份、硬脂酸镁3.5~7.5份。
2.根据权利要求1所述的治疗消化性溃疡的中药缓释剂,其特征在于:所述填充料包括糊精、蔗糖、乳糖之一或两种以上的混合物。
3.一种如权利要求1和2所述的治疗消化性溃疡的中药缓释剂的制造方法,其特征在于,包括以下步骤:
(1)将所述木香、所述薏苡仁、所述鸡内金、所述黄连、所述甘草、所述铁树叶、所述山楂、所述海螵蛸、所述蒲公英、所述三七、所述陈皮、所述佛手、所述金橘根先经过水提醇沉,将乙醇液过滤,滤液经大孔吸附树脂AB-8处理,用盐酸液洗脱,收集最后洗脱液,浓缩干燥后得干膏备用;
(2)将所述填料加水制成饱和溶液,加入所述干膏,充分研磨至成糊状物,40~60℃干燥,即得包合物;
(3)将所述羟丙基甲基纤维素及丙烯酸树脂作为骨架材料,与所述包合物混匀后制成软材;
(4)将步骤(3)得到的软材低温干燥,粉碎得细粉,以95%乙醇为润湿剂制粒,低温干燥,整粒;
(5)将上述干燥颗粒与硬脂酸镁加入三维混合机混合,压片,分装。
4.根据权利要求3所述的治疗消化性溃疡的中药缓释剂的制造方法,其特征在于:步骤(2)中所述填充料与所述干膏的重量比为1:1。
5.根据权利要求3所述的治疗消化性溃疡的中药缓释剂的制造方法,其特征在于:步骤(3)中还加入0.5~2份聚乙烯吡络烷酮作为粘合剂。
6.根据权利要求3所述的治疗消化性溃疡的中药缓释剂的制造方法,其特征在于:步骤(4)中所述细粉粒度为60~100目。
7.根据权利要求1~6所述的治疗消化性溃疡的中药缓释剂,其特征在于:所述中药缓释剂可以为片剂、胶囊剂、颗粒剂。
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