CN107854484A

CN107854484A - A kind of peritoneal dialysis solution

Info

Publication number: CN107854484A
Application number: CN201711056132.6A
Authority: CN
Inventors: 宋宏婷
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-10-27
Filing date: 2017-10-27
Publication date: 2018-03-30

Abstract

The invention discloses a kind of peritoneal dialysis solution, belong to medical field of dialysis, including the 15%W/V of sodium chloride 10, calcium chloride be 0.2 5%W/V, potassium chloride is 2 5%W/V, sodium acid carbonate is 2 5%W/V, magnesium chloride 2 5%W/V, the 10W/V of fucose 2 and the glucose less than 5%W/V.

Description

A kind of peritoneal dialysis solution

Technical field

The present invention relates to field of dialysis, a kind of specifically peritoneal dialysis solution.

Background technology

Dialysis（dialysis）It is that water is diffused into through semi-permeable membrane by small molecule（Or buffer solution）Principle, by small molecule A kind of separating and purifying technology separated with large biological molecule.Dialysis therapy is to make the composition in body fluid（Solute or moisture）Pass through half The treatment method that permeable membrane excretes, it generally can be divided into two kinds of haemodialysis and peritoneal dialysis.

Peritoneal dialysis（Peritoneal dialysis, PD）Be by the use of human body itself peritonaeum as dialysis membrane one kind Dialysis.Solute and moisture are carried out by pouring into the plasma fraction in the dialyzate in abdominal cavity and the capillary of peritonaeum opposite side Exchange, remove the metabolite of internal retention and excessive moisture, while pass through dialyzate and supplement material necessary to body. By constantly updating peritoneal dialysis liquid, reach kidney replacement or the purpose of supportive treatment.

Existing peritoneal dialysis is mainly used as osmotic pressure agent by glucose, among the process of dialysis, part glucose meeting By body absorption so that blood glucose rise, among metabolic disorder, and sterilization process harmful substance caused by glucose to human body all There is very big influence, influence dialysis-effect, while dewatering is poor.

The content of the invention

It is an object of the invention to：For above-mentioned problem, there is provided a kind of peritoneal dialysis solution, it is characterised in that bag It is 2-5 %W/V to include sodium chloride 10-15% W/V, calcium chloride 0.2-5%W/V, potassium chloride 2-5%W/V, sodium acid carbonate, chlorination Magnesium 2-5 %W/V, fucose 2-10 %W/V and the glucose less than 5%W/V.

Preferably, described fucose is 5-8% W/V, the concentration of glucose is less than 3%W/V.

Preferably, the concentration of each material is sodium chloride is 10% W/V, calcium chloride 0.2%W/V, potassium chloride 2%W/V, Glucose is 2% W/V, and sodium acid carbonate is 3 %W/V.

Preferably, the concentration of each material is sodium chloride is 12% W/V, calcium chloride 2%W/V, potassium chloride 3%W/V, Portugal Grape sugar is 2% W/V, and fucose is that 8 %W/V sodium acid carbonates are 3 %W/V.

Preferably, the pH value in dialyzate is 5-8.

Preferably, pH value is 6-7.5.

The invention also discloses a kind of preparation method of dialyzate, comprise the following steps：

Step 1: other materials in addition to fucose and glucose and water are mixed, homogeneous solution is formed；

Step 2: sterilization treatment is carried out at high temperature；

Step 3: adding fucose and glucose, homogeneous solution is formed；

Step 4: use filtering with microporous membrane.

A kind of preparation method of peritoneal dialysis solution according to claim 6, it is characterised in that described miillpore filter Filtering particle diameter be 0.2-0.4 μm.

Embodiment

In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.

Specific embodiment 1：A kind of peritoneal dialysis solution, including sodium chloride 10-15% W/V, calcium chloride 0.2-5%W/V, chlorine Change potassium be 2-5%W/V, sodium acid carbonate be 2-5 %W/V, magnesium chloride 2-5 %W/V, fucose 2-10 %W/V and less than 5%W/V Glucose.Described fucose is 5-8% W/V, and the concentration of glucose is less than 3%W/V.

Specific embodiment 2：The concentration of each material be sodium chloride be 10% W/V, calcium chloride 0.2%W/V, potassium chloride 2% W/V, glucose are 2% W/V, and fucose is 8 %W/V, and sodium acid carbonate is 3 %W/V, and pH value is adjusted to 7.

The concentration of 3 each material of specific embodiment be sodium chloride be 12% W/V, calcium chloride 2%W/V, potassium chloride 3%W/V, grape Sugar is 2% W/V, and fucose is that 8 %W/V sodium acid carbonates are 3 %W/V, and PH is adjusted to 6

Specific embodiment 4：Step 1: other materials in addition to fucose and glucose and water are mixed, homogeneous solution is formed；

Step 2: sterilization treatment is carried out at high temperature；

Step 3: adding fucose and glucose, homogeneous solution is formed；

Step 4: use filtering with microporous membrane.The filtering particle diameter of described miillpore filter is 0.2-0.4 μm.

Specific embodiment 5；Specific embodiment 5 is a comparative example relative to 2：The concentration of each material is sodium chloride It is 10% W/V for 10% W/V, calcium chloride 0.2%W/V, potassium chloride 2%W/V, glucose, sodium acid carbonate is 3 %W/V, pH value It is adjusted to 7.

Specific embodiment 6：It is a comparative example of embodiment 3：The concentration of each material is that sodium chloride is 12% W/V, chlorination Calcium is 2%W/V, potassium chloride 3%W/V, glucose are 10% W/V, and sodium acid carbonate is 3 %W/V, and PH is adjusted to 6.

In embodiment, tested with the white mouse of anesthesia, by 10ml, embodiment 2-3,5-6, injection white mouse is intraperitoneal, and 10 After hour, intraperitoneal liquid is reclaimed（Subtract the amount of liquid for anaesthetizing withdrawal liquid immediately）, measure the liquid of embodiment 5 and embodiment 6 The scale of construction is respectively 42 and 56, and the amount of liquid that embodiment 2 and 3 reclaims is respectively 64 and 78.

The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.

Claims

1. a kind of peritoneal dialysis solution, it is characterised in that including sodium chloride 10-15% W/V, calcium chloride 0.2-5%W/V, potassium chloride It is 2-5 %W/V, magnesium chloride 2-5 %W/V, fucose 2-10 %W/V and the Portugal less than 5%W/V for 2-5%W/V, sodium acid carbonate Grape sugar.

2. peritoneal dialysis solution according to claim 1, it is characterised in that described fucose is 5-8% W/V, glucose Concentration be less than 3%W/V.

3. peritoneal dialysis solution according to claim 2, it is characterised in that the concentration of each material is that sodium chloride is 10% W/ V, calcium chloride be 0.2%W/V, potassium chloride 2%W/V, glucose be 2% W/V, sodium acid carbonate is 3 %W/V.

4. peritoneal dialysis solution according to claim 1, it is characterised in that the concentration of each material is

Sodium chloride is 12% W/V, calcium chloride 2%W/V, potassium chloride 3%W/V, glucose are 2% W/V, and fucose is 8 %W/V Sodium acid carbonate is 3 %W/V.

5. peritoneal dialysis solution according to claim 4, it is characterised in that the pH value in dialyzate is 5-8.

6. peritoneal dialysis solution according to claim 5, it is characterised in that pH value 6-7.5.

7. the preparation method of the peritoneal dialysis solution according to claim any one of 1-5, it is characterised in that including following step Suddenly：

Step 2: sterilization treatment is carried out at high temperature；

Step 3: adding fucose and glucose, homogeneous solution is formed；

Step 4: use filtering with microporous membrane.

8. the preparation method of a kind of peritoneal dialysis solution according to claim 6, it is characterised in that described miillpore filter It is 0.2-0.4 μm to filter particle diameter.