CN107847620A - Use heterogeneous light microorganism sterilizing system and method - Google Patents
Use heterogeneous light microorganism sterilizing system and method Download PDFInfo
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- CN107847620A CN107847620A CN201680044724.3A CN201680044724A CN107847620A CN 107847620 A CN107847620 A CN 107847620A CN 201680044724 A CN201680044724 A CN 201680044724A CN 107847620 A CN107847620 A CN 107847620A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultra-violet radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/10—Beam splitting or combining systems
- G02B27/14—Beam splitting or combining systems operating by reflection only
- G02B27/141—Beam splitting or combining systems operating by reflection only using dichroic mirrors
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/032—Optical fibres with cladding with or without a coating with non solid core or cladding
- G02B2006/0325—Fluid core or cladding
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
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- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The present invention is a kind of equipment for being sterilized to the microorganism on fluid matrix or solid matrix.The equipment includes being used for the optical device for producing the light source of light and being positioned near light source.The optical device is configured as focusing on by the light of light source generation to provide high-strength light output.Optical device also includes dichroic reflector.The dichroic reflector is configured as transmitting the heat energy generated as light source and reflects the light as caused by light source.The equipment also includes power supply, and wherein power supply is coupled to light source and optical device.The equipment is so as to killing the existing microorganism in high-strength light output area.
Description
This application claims the priority for the U.S.'s non-provisional application the 15/223rd, 909 submitted on July 29th, 2016,
This application is the part continuation application for the U.S. Non-provisional Patent application the 14/815th, 519 submitted on July 31st, 2015,
It is incorporated herein by reference in their entirety.
Copyright statement
A part includes material protected by copyright disclosed in this patent.Copyright owner does not oppose that anyone replicates patent
Disclosed with the patent document or patent occurred in trademark office patent file or record, but retain all copyrights in other respects.
Background technology
Technical field
The present invention relates to a kind of equipment for being sterilized to microorganism.Especially, it is related to a kind of micro- for killing
The purpose of biology and the equipment for the treatment of patient.
Description of related art
Microorganism sterilizing has been crucial in the production for the biological products that storage time extends.Develop various
Technology realizes this sterilizing, and it includes ultraviolet irradiation, gamma-ray irradiation (or gamma-radiation), chemical sterilization, heat sterilization, height
Pressure sterilizing and ultrafiltration.Because these technologies destroy microorganism, they are inherently damaged may be in its in product subject to sterilization
Allogene composition.In view of the fact that, for being sterilized to given biological products, particular technology can not always may connect
Receive.Recently, the increase of the number and type of biological technology products has generated the demand to sterilizing enough, and to product
Ideal composition does not have destructive side effect.These biological technology products are often highly unstable, it is necessary to specially treated and storage
Condition with keep its activity.In previously cited sterilization technology, for these biotechnology applications, several sterilization technologies can not
Receive.Chemical sterilization, heat sterilization and autoclaving all can damage or change biomolecule, so that it is inactivated.Biomolecule
Inactivation has effectively killed the microorganism that life process is carried out using these molecules.However, the biology occurred in the prior art point
This inactivation of son be substantially it is problematic, in it is also possible that required molecule or more included in biological technology products
Individual molecule inactivation, so that sterilizing purpose fails.
Ultrafiltration needs to use hole size very small (at least (relative to the state-of-the-art technology of other technologies described herein)<
0.45 micron) filter.These filters are a kind of inherently slow sterilizing means, may be suitable for highly viscous molten
Liquid or the solution containing required particle (such as cell), these particles are bigger than aperture, therefore can not pass through filter greatly very much.
Gamma-irradiation is the technology that a kind of microorganism sterilizing is of little use, although it can be used to ensure that most of (if not all)
The aseptic of biological technology products.It lacks that to be widely used in a main cause of microorganism sterilizing be that it make use of and has very much
Radioactivity therefore breakneck radiation source, such as radioactive cobalt.This technology needs a large amount of shieldings and control system to prevent
Accidental exposure is in operating personnel and other staff.These protections require economically expensive, generally very expensive.Therefore, γ-photograph
Penetrate not usually economically acceptable technology or the safe practice for being sterilized to biological technology products.Additionally, γ-
The biomolecule included by dissolving in microorganism is irradiated come sterilising prods.The photochemistry mechanism of this sterilizing is also possible to the institute that degrades
Product is needed, makes its inactivation, so that sterilizing purpose fails.
UV- irradiations have been widely used for microorganism sterilizing.UV photo damages include the DNA polymerizations of cell or the genome of virus
Hydrogen bond in thing between adenine-thymidine part, and it is catalyzed formation cyclobutane dimerization between adjacent thymine part
Body.This destruction of genome has blocked cell or the replicative cycle of virus, restrained effectively the growth of organism.
Generally, the equipment that product sterilizes is set by power supply (ballast), UV light sources, optically focused and/or leaded light using UV light
Standby, filter and control system composition, to ensure suitably to operate.Ballast is designed to provide electric power by lamp of reliable fashion,
To ensure the lasting optimal function of lamp.Various UV light sources in the prior art be present, and learn in the prior art, it includes arteries and veins
Rush inflatable flash lamp, spark discharge device or low pressure mercury vapor lamp.Traditionally, low pressure mercury vapor lamp has been used for microorganism
Sterilizing installation, because the operation of these lamps is relatively cheap, and launch the UV irradiations of relative higher amount than other sources.Also use
Other kinds of mercury vapo(u)r lamp, it includes mercury-xenon (HgXe) lamp.Specifically, according to a preferred embodiment of the invention using pencil-type
Hg (Ar) spectroscopic calibration lamp.These modulated structures are compact, and provide narrow and strong radiation.Their mean intensity it is constant and
It is reproducible.It is longer relative to other high wattage lamps, their service life.Such mercury (Ar) lamp is generally unwise to temperature
Sense, and only need two minutes heating mercury vapour to be occupied an leading position so as to discharge, then need 30 minutes complete stabilities.
By background, light is routinely divided into infrared light (780nm to 2600nm), visible ray (380nm to 780nm), near
Ultraviolet light (300nm to 380nm) and extreme ultraviolet light (170nm to 300nm).Light is launched in most of UV lamp sources with discrete wavelength, and
And including optical filter, it filters out or stopped the wavelength beyond specific UV wavelength, particularly 254nm.It is most significant in UV regions
UV launch 254nm at generation.Known mercury vapor lamp launches radiation at 254nm.This wavelength can destroy cell and disease
The genome of poison, so as to suppress their duplication, so as to kill cell and virus.Therefore, generally, in the prior art, tune
Single wavelength detecting to 254nm has been used for the amount for determining that the UV for reaching target is radiated.In order to optimize the UV light of lamp source
Delivery efficiency, at least one optical filter is inserted in the optical path to stop that non-UV light reaches target, so as to only allow UV and nearly UV light
Reach target.Therefore, over time, the sector develops 254nm over time is gone out for UV
The example of the firm foundation of unique and exclusive important wavelength of bacterium.Gone out in this way, teaching in prior art does not include for microorganism
The light of the non-UV wavelength of bacterium device.Further, this example not only instructs polychrome or broad-spectrum light uncorrelated or inessential, and
And it is unfavorable.
With irradiating to form sharp contrast using the UV of photo-thermal and/or photochemistry mechanism, Dunn (authorize by October 3rd, 1989
Dunn et al. U.S. Patent number 4,871,559, entitled METHODS FOR PRESERVATION OF FOODSTUFFS) religion
Lead and photothermal mechanisms are utilized by visible and infra-red radiation inactivator.When with high intensity and combination application, as being included in
UV, IR and visible ray of component in whole spectrum are by killing microorganism and causing the significant of food by the inactivation of digestive enzyme
Pot-life and stability enhancing.It is worth noting that, the prior art of the ultraviolet disinfection in biotechnology applications is not taught
Lead the approach of Dunn multigroup light splitting application；Because teaching in prior art needs filtered UV light, and filtered UV light
Sterilizing for microorganism is undesirable, so prior art is not instructed using filtered UV light to enter to microorganism
Row sterilizing.Disadvantageously, the activity of biological technology products is typically based on enzymatic activity or needs the three or four structure of protein
To carry out activity.Therefore, do not made any distinction between in sterilization process ground protein degradation matter and enzyme sterilization technology (such as Dunn) for
It is unacceptable that biological technology products, which are used together,.Therefore, there is still a need for a kind of sterilization technology, it can be effectively to biology
Product is sterilized, without being denatured active biologics.
More have in the case where not making active biomolecule excessively be denatured therefore, it is also desirable to which prior art is still unsolved
Effect ground sterilizes to the biological product of microorganism.
The content of the invention
Thus, it has been found that the limitation of prior art can be overcome with the dichroic reflector that UV light sources are used together.Cause
This, embodiments of the invention include herein below.
In the first embodiment, there is provided a kind of to be used for what the microorganism on fluid matrix or solid matrix was sterilized
Equipment, the equipment include：
A. light source, it is used to produce light；
B. optical device, it is positioned near light source, wherein optical device be configured as light caused by focused light source with
High-strength light output is provided；And wherein optical device includes：
I. dichroic reflector, wherein dichroic reflector are configured as making the heat energy as caused by light source anti-by dichroic
Emitter；And light caused by reflection source；
C. power supply, wherein power supply are coupled to light source and optical device；And
D. the microorganism wherein in high-strength light output area is killed.
In another embodiment, there is provided a kind of microorganism sterilizing equipment for being used for the matrix with high-strength light output,
It includes flexible fluid core light guide, and the flexible fluid core light guide includes：
A) first end；
B) the second end；
C) tubular body；And
D) wherein light guide is configured as being positioned at optical device nearby and is connected with the first end near optical device, makes
High-strength light output is obtained to be configured as focusing on the first end of fluid core light guide and guide by the second end of tubular body direction simultaneously
And it is led out to by the second end in the matrix to be sterilized.
In another embodiment, there is provided a kind of method for providing microorganism sterilizing, it comprises the following steps：
A) equipment for being sterilized to the microorganism on fluid matrix or solid matrix is provided, wherein the equipment bag
Include：
I. polychromatic source, it is used to produce polychromatic light；
Ii. optical device, it is positioned near polychromatic source, and wherein optical device is configured as focusing on by polychromatic source
Caused polychromatic light is exported with providing about 0.1J/cm2 to about 50.0J/cm2 high-strength light；The equipment includes：
A. dichroic reflector, wherein dichroic reflector are configured as transmitting the heat energy as caused by polychromatic source；And
Reflection polychromatic light as caused by polychromatic source；
B. power supply, wherein power supply are configured to coupled to polychromatic source and optical device；
B) the one predetermined time of polychromatic source is activated to provide the time for exposure more than about 0.01 second；
C) output of equipment is positioned at away from pending one predetermined distance of matrix；
D) pending matrix is exported exposed to high-strength light；And
E) inactivate polychromatic source, so as to allow any microorganism agent present on matrix to have sterilized.
The brief overview of some example embodiments
There is provided present invention will further describe in the following specific embodiments in order to introduce in simplified form
The selection of concept.Present invention is not intended to the key feature or essential characteristic for identifying theme claimed, is not intended to
For assisting in the scope of theme claimed.
One example embodiment includes a kind of equipment for sterilising microbe.The equipment includes being used for the light source for producing light
And it is positioned in the optical device near light source.It is high-strength to provide that the optical device is configured as focusing light as caused by light source
Spend light output.The optical device also includes dichroic reflector.Dichroic reflector is configured as transmitting hot as caused by light source
The light as caused by light source and can be reflected.The equipment also includes power supply, and wherein power supply is coupled to light source and optical device.The equipment
So as to kill the existing microorganism in high-strength light output area.
In one embodiment, microorganism sterilizing equipment includes flexible fluid core light guide.Flexible fluid core light guide includes the
One end and the second end.Flexible fluid core light guide also includes tubular body.Light guide be configured as being positioned at optical device nearby and with
First end connection near optical device so that high-strength light, which exports, to be configured as in the first end for focusing on fluid core light guide simultaneously
And guiding is led out to the matrix to be sterilized in towards the second end and by the second end by tubular body.
Another example embodiment includes a kind of method for providing microorganism sterilizing.This method includes：There is provided for going out
The equipment of bacteria microorganism.The equipment includes being used to produce heterogeneous light polychromatic source and the light being positioned near polychromatic source
Learn equipment.The optical device is configured as focusing on as caused by polychromatic source polychromatic light to provide about 0.5J/cm2 high intensity
Light output.The optical device also includes dichroic reflector.Dichroic reflector is configured as transmitting the heat energy as caused by light source
And reflect the light as caused by light source.The equipment also includes power supply, and wherein power supply is coupled to polychromatic source and optical device.The party
Method also includes：The one predetermined cycle of polychromatic source is activated to provide the exposure cycle of greater than about 0.01 second.This method is also wrapped
Include：The equipment is positioned at away from pending one predetermined distance of matrix.Additionally, this method includes：By pending base
Matter exports exposed to high-strength light.In addition, this method also includes：Polychromatic source is inactivated, it is any present on matrix so as to allow
Microorganism agent has sterilized.
From the following description and the appended claims, these and other purposes of the invention and feature will become more to show and easy
See, or can be understood by practice of the invention as described below.
Brief description of the drawings
, will be by reference to scheming in the accompanying drawings for the various aspects of some exemplary embodiments that the present invention is furture elucidated
The specific embodiment shown come reproduce the present invention be discussed in greater detail.It will be appreciated that these accompanying drawings depict only the explanation of the present invention
Embodiment, therefore be not considered limiting of its scope.Will by using accompanying drawing with more features and details describing and
The present invention is explained, wherein
Fig. 1 illustrates the side view of the equipment for microorganism sterilizing.
Fig. 2 be a diagram that the flow chart of the method for providing microorganism sterilizing.
Embodiment
Referring now to accompanying drawing, wherein identical structure will be provided with identical reference marker.It should be appreciated that accompanying drawing is
The diagram of some embodiments of the present invention and schematically show, and not limitation of the present invention, also paint not necessarily to scale
System.
Although the present invention is susceptible to the limitations of many various forms of embodiments, it is shown in the drawings and here
It will be described in detailed specific embodiment, it will be appreciated that the disclosure of such embodiment will be considered as showing for principle
Example, and be not intended to and limit the invention to shown and described specific embodiment.In the following description, identical accompanying drawing
Mark for accompanying drawing is described several views in identical, similar or corresponding part.The embodiment defines herein
Used in term implication and embodiment has been described in detail, so as to those skilled in the art put into practice the present invention.
Definition
Term " about ", " substantially " and " about " mean ± 10%.
Term " one (a) " used herein or " one (an) " are defined as one or more than one.Institute herein
The term " multiple " used is defined as two or more than two.Term " another " used herein be defined as to
Few two or more.Term " including (including) " used herein and/or " having (having) " are defined
It is to include (that is, open language).Term " coupling " used herein is defined as connecting, although not necessarily directly connecting
Connect, and be not necessarily mechanical connection.
Term " including (comprising) ", which is not intended to, to be limited the invention to only protect including language requirement with such
The present invention.Can be used using any invention of term " including (comprising) " " by ... form (consisting) " or
" by ... forming (consisting of) " claim language is separated into one or more claims, and is intended to such.
Mean to tie through reference of this document to " one embodiment ", " some embodiments " and " embodiment " or similar terms
Special characteristic, structure or the feature for closing embodiment description are included at least one embodiment of the invention.Therefore, run through
This specification is not necessarily all referring to identical embodiment in such phrase that each place occurs.Further, special characteristic,
Structure or feature can combine in any suitable manner in one or more embodiments, without limiting.
As used herein, the term "or" it is to be interpreted for inclusive or mean any one or any combinations.Cause
This, " A, B or C " refer to any one of the following：“A；B；C；A and B；A and C；B and C；A, B and C ".Only when element, work(
When energy, step or the combination of action exclude each other to a certain extent, the exception of this definition just occurs.
Accompanying drawing shown in accompanying drawing is to illustrate some convenient embodiments of the present invention, and be not considered as to it
Limitation.Desired function of term " means " instruction with one or more embodiments before the present participle of operation, i.e.
For realizing one or more methods, the device of desired function, and those skilled in the art can be with view of herein
Disclosure selected from these or their equivalent, and the use of term " means " be not intended to it is restricted
's.
As used in the specification and in the claims, phrase " being configured as " is represented the element fundamentally
The actual disposition state connected with the physical characteristics of the structure.That is, phrase " being configured as " represents the element
The element is able to carry out in structure, but need not so be done at any given time.As a result, phrase " being configured as " is remote
Far beyond only representation function language or desired use, because the phrase states actual disposition state on one's own initiative.
As used herein, term " is used to set to what the microorganism on solid matrix or fluid matrix was sterilized
It is standby " refer to the equipment with light source, the light source, which produces, can kill the microorganism (bacterium on such as solid matrix or fluid matrix
Or virus) broad-spectrum light.Especially, it produces wide ultraviolet spectra (that is, not exclusively isolating wavelength), even if it can produce it
His spectrum, and in one embodiment, light produces high UV outputs.Solid matrix and fluid matrix refer to non-pneumatic matrix, all
Such as liquid, blood, skin, bone, organ or abiotic liquid/solid.
As used herein, term " light source " refers to any kind of bulb for producing sterilizing UV light.Common bulb
Also high-intensity discharge (HID) bulb is also embodiments of the invention.Thus, for example, high intensity mercury xenon (HgXe) can be utilized
Bulb.The bulb of these types is high UV outputs bulb.In general, the light output of some bulbs of the present invention is about 0.1J/
Cm2 to about 50.0J/cm2.
As used herein, term " optical device " refers to collect light from dichroic reflector reflection and by light
The equipment focused in height output stream.Focus on and produce high-strength light output.The equipment can be electronic or have manual optically focused
Mode.
As used herein, term " high-strength light output " refers to the light output of about every watt output at least 80 lumens,
To realize the output of this high-strength light, it is impossible to using the low pressure or middle pressure lamp for producing UV light because they will not produce it is enough
Light output.It is horizontal that arc discharge lamp will not produce required light output intensity really., can in order to realize required high intensity output
To increase ellipsoidal reflector in the light output of arc discharge lamp, polychromatic light is collimated into every watt of about 100 lumens by the reflector
The higher intensity (intensity is understood to the energy of unit area) of (that is, producing required high-strength light output).
As used herein, term " dichroic reflector " refers to obtain light from light source and allows heat energy through instead
Emitter simultaneously by light, particularly UV light reflex to optical device be used for focus on reflector.Reflector can be any of work
Shape, but be oval in one embodiment.This is different from dichroic filter, and the latter only filters or reflected light, but
It is not reflect heat.
As used herein, term " power supply " refers to for light source power supply and is optical device when needed or this sets
AC the or DC sources of standby any other part power supply.
As used herein, term " polychrome " refers to the light for including the light of multiple wavelength.
As used herein, term " predetermined exposure cycle " refers to that light is on microorganism as caused by equipment
Show to kill the period of the microorganism.In one embodiment, the period was from about 0.01 second to about 5 seconds.One
In individual embodiment, passage of the light from light source to microorganism is opened, closes and modulates using shutter.
As used herein, term " fluid core light guide " refer to be used for allow light focus set launch and as needed
Help is delivered into product matrix or the light guide of patient.Although what the light guide was not required for using the present invention,
It is that it is to aid in focusing on or makes it easier to the light of focusing being delivered to the embodiment of desired locations/matrix, patient etc..The light guide
Typically one pipe, it has first end and the second end, and wherein first end is used to collect slave unit when being positioned near equipment
The light of output so that light guiding is by managing and being delivered to the second end and its outer, to deliver light when needed, for example, matrix.
Light guide can include collimater.Light guide can be at least one in the following：Flexible；Ultraviolet (uv) transmission；Have or
Person is liquid；With saline solution；With metal salt solution, wherein in one embodiment, metal salt is Na, K, Mg or its group
Close；Non-aqueous solution；Or gas.
The present invention relates generally to microorganism sterilizing (or DNA is destroyed, DNA inactivations), and relate more specifically to using optional
The microorganism sterilizing for the heterogeneous light short pulse of high intensity that ground is pointed to by the infrared absorption light guide of flexibility.In the purpose of the present invention
A purpose be by more effectively being sterilized to any matrix of bio-matrix, product or microorganism, without making activity
Any active biomolecule in biomolecule is excessively denatured (for example, being sterilized to the microorganism of body surface) to change
Enter prior art.It is another object of the present invention to modulate the exposure cycle to polychrome full spectrum light using tripper.This hair
Another bright purpose is to remove heat energy using dichroic reflector and focus on (concentration) polychrome full spectrum light.The present invention's is another
Purpose is to modulate lamp power, the heat of polychrome full spectrum light and shutter timer using electronic circuit board.
Therefore, it is an aspect of the invention to provide a kind of device, it will pass through high intensity polychrome or wide range light irradiation (bag
Include UV irradiations) biological product, abiotic product or other products are sterilized.Another aspect of the present invention is to provide one kind
Device, it is using by the light of filtering flow come the region of ultra-red of absorption spectrum, to make the expectation of illuminated object
The photo-thermal denaturation of element minimizes.(such as muscle, fat, bone, hair, fluid, plant and true it is believed that those structures
Bacterium structure) all influenceed by this light.Additionally, non-biological material (such as plastics) is also to destroy DNA by purpose
Bactericidal light influence, and we design provide execution it is smaller.With removing the heat associated with this processing,
Biological surface and other surfaces and matrix also none escape by luck.
As shown in figure 1, the embodiment provides a kind of equipment for microorganism sterilizing, it is commonly labeled as
100.Fig. 1 shows that the equipment 100 for microorganism sterilizing can include power supply 102；UV light sources 104；At least one optics is set
Standby 106 (in this embodiment, it includes dichroic reflector 108)；Shutter mechanism 110；Cooling fan 112；Timer 114；
Light guide or light guide conductive device 116 (also serving as infrared light-filter) with first end 117a and the second end 117b；And expose
Optimizing Control System 118, to ensure suitably to operate.It is further characterized in that light shield box 122, detector circuit 124 and neutral density
UV sensitive diodes in optical filter and UV selective filters 123.Fig. 1 also show invisible infrared light (radiations heat energy)
130th, incident beam 129, microorganism 121 and matrix 120.The part of the present embodiment is configured, positions and connected so that in the reality
Apply in example and provide energy from the power supply 102 that electronic circuit board forms to system.Especially, power supply provides energy to UV light sources 104,
The UV light sources 104 launch the light from the reflection of at least one optical device 106, otherwise focus on or are directed in light guide 116.Dichroic
Reflector 108 provides the device for removing heat from system.Cooling fan 112 provides unnecessary for being removed from system
Another device of heat.Tripper 110, timer 114 and control system 118 are connected with each other has microorganism to provide to reach
The controlled ON/OFF light output of 121 matrix 120.
In one embodiment, the present invention includes power supply 102, and it is made up of electronic circuit board；Mercury as UV light sources 104
Xenon (HgXe) lamp；Oval dichroic reflector 108 in optical device 106；Shutter mechanism 110；Also serve as infrared light-filter
Light guide 116；And control system 118.In one embodiment, power supply 102 is made up of ballast, and the ballast is with appropriate electricity
Pressure and electric current provide electric power to be powered to ultraviolet (UV) light source 104.In another embodiment, power supply 102 is made up of transformer, should
Transformer is provided electric power with appropriate voltage and electric current and powered with UV light sources 104.In another embodiment, power supply 102 is electronics electricity
Road plate (PCB), it provides electric power to be powered to ultraviolet (UV) light source/lamp 104 with appropriate voltage and electric current.Electronic circuit board will
Other electronic equipments are connected to lamp igniter typically associated with power supply.The lamp igniter provide 8 amperes to 12 amperes with
Start lamp.For 100W Hg or Hg/Xe lamps, power supply keeps about 3 amperes to 5 amperes of lamp output.
In one embodiment, UV light sources 104 are HgXe mercury vapo(u)r lamps, although it is also contemplated that other UV light sources.HgXe's
Intensity is enough to provide about 0.01 between about 170 nanometers (nm) to the wavelength between about 2600nm according to microorganism 121 subject to sterilization
Joule/square centimeter (J/cm2) is to the energy density between about 50J/cm2.In another embodiment, micro- life subject to sterilization is impinged upon
Energy density on thing 121 is about 0.5J/cm2.Advantageously, by be enough to prevent the speed that lamp overheats by air or fluid
The continuous flowing of (being preferably water) is directed on lamp to cool down lamp.
Additionally, dichroic reflector 108 helps to dissipate from lamp 104.Dichroic reflector tends to be characterised by it
Be configured as reflection light one or more colors, rather than their one or more colors for passing through, itself and dichroic filter
Mating plate, Thin Film Filter or interferometric filter are on the contrary, they are point-device optical filters, it is characterised in that their selectivity
The color of the light passed through.Dichroic reflector 108 can use behind light source/lamp 104, with reflected frontward visible ray (or its
His institute's light requirement) 129, while allow the rear portion of the slave unit 100 of sightless infrared light (radiations heat energy) 130 to go out, produce actual
On colder (hot temperature is relatively low) light beam 129, i.e. heat reduce 80%.Such arrangement allows given light 129 is significant to increase it
Forward direction intensity, while allow to be escaped by the heat that the rearward portion of equipment 100 generates.In one embodiment, dichroic reflector
Device 108 is oval.The dichromatic surfaces of reflector 108 are made up of face coat, and the face coat is enough to allow major part
Incident light 129 reflects, while allows hot light 130 to pass through.Elliptical shape is designed so that the impact launched by light source 104 is anti-
Most of light of emitter 108 is reflected and focuses on the first end 117a towards light guide equipment 116.
Traditionally, exposure cycle modulation is by the way that current-modulation to lamp is completed.This spectrum assignment system using electric current
System is relatively economical, therefore is widely accepted.However, caused due to the break-make of electric current the lasting flicker of light source/lamp for
Light source/lamp is unfavorable, and causes the lamp lost of life.Therefore, light source/lamp 104 maintains continuous pump during use, and
Exposure modulation is occurred by tripper 110.Tripper 110 can be delivered between about 0.01 second and about 5 seconds, excellent
Selection of land is between about 0.1 second and about 3 seconds, the exposure cycle of more preferably about 3 seconds.In addition, tripper 110 can be with
Repetitive mode delivers these exposure cycles, to realize the total exposure time for being enough to be sterilized to microorganism 121.During low exposure
Between can be crucial to ensure to occur sterilizing without damaging following matrix 120.Preferably, the exposure interval is generally about
In the range of 0.01 to about 3 second, it is preferable that 0.1 second.
The fluid core light guide that light guide equipment 116 is made up of the pipe with fluid core, the pipe have first end 117a and
Two end 117b.Pipe in light guide 116 is flexible hollow tube, and its wall is by equally high or higher in itself at least with the fluid that is accommodated
The high reflection material of reflectivity is formed, and so as to increase the transmissivity in light guide 116, or at least maintains the transmission of fluid in itself
Rate.Additionally, the high reflection material used in tube wall has diffraction coefficient, if it, which is sufficient so that it, contacts tube wall, passes through
Most of light in the range of the 200nm to 1200nm of the fluid core of pipe is reflected back in fluid core.
In photoconductive device 116, fluid core is by gas, aqueous metal salt (or other aqueous solution) or non-aqueous solution structure
Into.Fluid in fluid core light guide 116 is formulated such that its absorption can be launched and be sent to by HgXe lamps/light source 104
Infrared light in fluid core light guide 116.In one embodiment, the non-aqueous solution that fluid is made up of organic fluid.Organic stream
Body is due to being preferable for this purposes with high IR (IR) absorbability, and infrared light can destroy microorganism
121 protein, enzyme and cell component, so as to eliminate the viability for the sterilized bio body for being used as vaccine.In another embodiment
In, fluid is aqueous metal salt, such as sodium chloride (NaCl) aqueous solution, although salt can also be selected from KCl, MgCl, MgSO4,
The group of the compositions such as other organic matters.NaCl concentration is between about 5% to about 50%.Preferably, concentration can be big
In the range of about 5% to about 10%.
The end 117a and 117b of light guide 116 can be by translucent quartz, fused silica or diamond synthesis or natural Buddha's warrior attendants
It is made of stones into all these not absorb UV light.The light that light guide 116 will move out is directed to micro- in matrix 120 from the second end 117b
Biology 121.Additionally, the dichroic reflector 108 with suitable shape is used for the micro- life for focusing on the light of reflection in matrix
On thing 121, while make heat energy 130 away from substrate 120 to prevent from damaging matrix 120 while sterilising microbe 121.
The normal operation of sterilizing installation 100 is ensured by control system 118.Control system 118 by be placed on on substrate 120
The juxtaposed light shield case 122 of microorganism 121 in UV sensitive diodes form.UV sensitive diodes 122 are coupled to detector
Circuit 124, the detector circuit 124 offer instruction impinge upon the light quantity on UV sensitive diodes 122 during exposure cycle
Output.Neutral-density filter and UV selective filters 123 are inserted between light guide 116 and UV sensitive diodes 122, with
Decaying respectively light and prevents the wavelength outside UV scopes from passing through.Detected in detector circuit 124 and impinge upon UV sensitive diodes
In the case that light on 122 is less than enough level, it can increase and be delivered to light source/lamp 104 (it can be flash lamp, coal gas
Lamp etc.) power, can be with the prolonged exposure cycle, or disinfecting action can be suspended, untill equipment 100 can be by maintenance.
In another embodiment, the alternative means for controlling UV light quantity of the land on the microorganism 121 on substrate 120 are to make
The UV light on UV sensitive diodes 122, detector circuit 124 are impinged upon with control system 118 as described above, rather than measurement
Device with measuring the fluorescence launched by microorganism 121 matches.It is used to carry out using polychromatic light it should be appreciated that fluorescence is the equipment
Microorganism sterilizing is used for the key factor for inactivating the validity of microorganism.Fluorescence is the instruction of state of activation, and be absorb with
The result of the energy-rich radiation of low energy wavelength transmitting.The state of activation be considered as it is associated with bigger chemical reactivity, because
This is considered as to be advantageous to form cyclobutane dimer in cell or the genome of microorganism.
Unlimited application is of virtually according to the equipment 100 for microorganism sterilizing of the present invention.By example, but it is unlimited
In, the equipment can be used for inactivating and/or sterilize by producing vaccine from the microorganisms of one or more sterilizing it is all
Know pathogen, these pathogen include viral (such as herpes simplex virus and HIV), bacterium (such as Escherichia coli and grape ball
Pseudomonas) and fungi (such as candidiasis).
It is further advantageous that according to the present invention the equipment 100 for microorganism sterilizing can be used at a distance or greatly consolidate
Determine matrix to be sterilized.By constructing on such material of the equipment entrained by manufacturer and the equipment 100 of technology, if
Standby 100 can be used for quick sterilization distant place or big matrix areas.In such embodiments, by simply maintaining light guide
116 make light 129 in matrix area towards the direction of matrix and while the administrative staff that sterilize may move or go about
Moved on domain, personnel's (being in this case, the keeper that sterilizes) easily can sterilize to big matrix areas.
Fig. 2 be a diagram that the flow chart of the method 200 for providing microorganism sterilizing.This method allows to any desired base
Matter is sterilized, without damaging structure, such as muscle, fat, bone, hair, fluid, plant and fungi structure.Especially,
The bad components of high-strength light have been eliminated so that gained output only damages microorganism, without damaging following structure.
Fig. 2 shows that this method can include：202 equipment for being used to sterilize to microorganism are provided.For example, join above
According to Fig. 1, the equipment for being sterilized to microorganism can include equipment 100.Therefore, the equipment 100 of reference picture 1 is carried out into example
Method 200 is described to property.However, it will be appreciated by one skilled in the art that method 200 can with addition to Fig. 1 equipment 100
Equipment be used together.
Fig. 2, which also show method 200, to be included：The activation one predetermined cycle of (204) polychromatic source is big to provide
In the exposure cycle of about 0.01 second.For example, exposure cycle can be from 0.01 second to about 5 seconds, it is preferable that between about 0.1
Between second arrives about 3 seconds, it is highly preferred that about 3 seconds.In addition, tripper can deliver these exposure cycles with repetitive mode,
It is enough the total exposure time for killing microorganism to realize.
Fig. 2, which further illustrates method 200, to be included：Equipment positioning 206 is predefined apart from pending matrix one
Distance at.For example, the equipment can position 206 positions at about 2.25 inches from matrix.Distance can be based on processed
Matrix, the intensity of output, the microorganism that is sterilized and other facts adjust.
Fig. 2, which additionally illustrates method 200, to be included：Pending matrix exposure 208 is exported in high-strength light.Also
It is to say, high-strength light output is directed into matrix, so as to be sterilized to microorganism thereon.Exposure can include constant exposure
Light or " scanning ", it moves high-strength light along matrix and exported.
In addition, Fig. 2 shows that method 200 can include：Polychromatic source is inactivated 210, be present in so as to allow in matrix
Any microorganism reagent is sterilized.That is, once microorganism has been sterilized, light source is turned off and matrix is present
It is sterilized for intended use.
Those skilled in the art will be appreciated that for disclosed herein this and other processes and method, in process
It can be realized in different order with the function of being performed in method.Further, the step of summarizing and operation, which are only used as, to be shown
Example provides, and some steps and operations in steps and operations can be optional, be combined into less step and operation, or
Person expands to additional step and operation, without departing from the essence of the disclosed embodiments.
Invention has been described, now will be by example in detail below to more specifically preferred embodiment
It is explained in more detail with the various aspects of the invention of example.These examples quantitatively demonstrate the present invention and pass through reduction
Or microorganism is eliminated to preserve the validity of biological technology products.In these examples, microorganism is intentionally introduced into pending
In product.The microorganism of high quantity be intentionally introduced into product can cause microorganism height self shielding, so as to conventional number
The microbial ratio of amount is, it is necessary to increase the open-assembly time to the light that sterilizes.Therefore, these examples represent the effective of high-strength light processing
Property dramatic proof.
Example 1
Experiment of the example based on the light guide progress using the fluid filling commercially available from Edmund Scientific, should
Light guide is clamped in the light transmitting terminal of light guide substantially perpendicular to the to be exposed and position of sterilization matrix, and it is apart from matrix about 2.25
Inch.The light guide of fluid filling be connected in front of the light source and with the diaphragm shell and tripper of light source couples,
In the experiment, light source is high-power 1 kilowatt of mercury-xenon (HgXe) lamp, and it can be from AmericanLESCO
Commercially available from UV departments.Herpesviral (HSV) culture is by being enough to provide culture supernatants to 106 plaque-forming units
(PFU)/mL dilution carrys out the cell preparation from herpesvirus infection into cell culture medium.According to one embodiment,
About 10mL aliquot is exposed to away from equipment 2.25 " distance at UV light continue cycle of 3 seconds.Exposure cycles it
Afterwards, 2mL three parts of samples are taken out from the sample through processing and incubate 72 for freshly prepared HSV cells and at 37 DEG C
Hour.By the inspection of 3 days, plaque is not observed in the sample through processing, and observing positive control sample has
106PFUS/mL titre；Therefore, test start when, in one embodiment, according to the present invention, 106PFU/mL processed 3
Second, so as to produce zero (0) PFU/mL after using high-intensity light source exposure.
Additionally, (Escherichia coli, staphylococcus and Cray primary are included but is not limited to bacterium and other viruses with UV light
Pseudomonas) sxemiquantitative sterilized.These are only illustrated by example and unrestricted.When exposed to according to the present invention's
During equipment, in a similar manner and the similar condition pair of the condition with being illustrated in example 2 and family, ventilation, excrement, Human Oral Cavity
Other bacteriums that those common bacteriums are similar in similarly inactivate and sterilize.
Those skilled in the art in the invention can make modification, so as to particularly in the situation in view of foregoing teaching
Under, cause the other embodiment using the principle of the invention, without departing from its spirit or feature.Thus, described embodiment exists
All aspects are considered to be illustrative and be not restrictive, therefore the scope of the present invention is by appended claims rather than by preceding
Bright or accompanying drawing is stated to indicate.So as to although describing the present invention, those skilled in the art by reference to specific embodiment
Obviously the modification to structure, sequence, material etc. is still fallen within as in the range of the applicant's claimed invention.
Claims (20)
1. a kind of equipment for being sterilized to the microorganism on fluid matrix or solid matrix, the equipment includes：
A. light source, it is used to produce light；
B. optical device, it is positioned near the light source, wherein the optical device is configured as focusing on the light source production
Raw light is exported with providing high-strength light；And wherein described optical device includes：
I. dichroic reflector, wherein the dichroic reflector be configured as passing through the heat energy as caused by the light source it is described
Dichroic reflector；And reflection light as caused by the light source；
C. power supply, wherein the power supply is coupled to the light source and the optical device；And
The microorganism in wherein described high-strength light output area is killed.
2. equipment according to claim 1, wherein the light source is polychrome.
3. equipment according to claim 1, wherein the light source includes high-intensity lamp.
4. equipment according to claim 3, wherein the light source includes high intensity HgXe lamps.
5. equipment according to claim 1, wherein the light source is high UV output light sources.
6. equipment according to claim 1, wherein the light source, which is activated, is just enough to kill the one pre- of the microorganism
The exposure cycle first determined.
7. equipment according to claim 6, wherein the exposure cycle is greater than about 0.01 second.
8. equipment according to claim 7, wherein the exposure cycle is between about 0.01 second and about 5 seconds.
9. equipment according to claim 6, in addition to：
Tripper, wherein the tripper is positioned and connected near the optical device, for by described in modulation
Light source controls the exposure cycle.
10. equipment according to claim 1, in addition to fluid core light guide, the fluid core light guide include：
A. first end；
B. the second end；
C. tubular body；And
D. wherein described light guide is positioned in optical device nearby and is connected with the first end near the optical device,
So that the high-strength light output is focused onto in the first end of the fluid core light guide, and guides and pass through the tubulose
Body is led out in matrix subject to sterilization towards second end and by second end.
11. equipment according to claim 10, wherein the light guide includes collimater.
12. equipment according to claim 11, wherein the high intensity collimated light is delivered near the optical device
The light guide first end.
13. equipment according to claim 1, wherein the dichroic reflector is oval.
14. equipment according to claim 1, wherein the power supply includes electric ballast, it is configured as adjusting heat
Exclude.
15. a kind of flexible fluid core light guide, for being carried out to fluid matrix or solid matrix in the equipment of microorganism sterilizing, this sets
It is standby that there is high-strength light output and include including the flexible fluid core light guide, the flexible fluid core light guide：
A) first end；
B) the second end；
C) tubular body；And
D) wherein described light guide be configured as being positioned at optical device nearby and with described first near the optical device
End connection so that the high-strength light, which exports, to be configured as in the first end for focusing on the fluid core light guide and guide
It is led out to by the tubular body towards second end and by second end in the matrix subject to sterilization.
16. flexible fluid core light guide according to claim 15, wherein the fluid core light guide is IR absorbefacient.
17. flexible fluid core light guide according to claim 15, wherein the fluid core light guide be in the following extremely
One item missing：
A) it is flexible；
B) ultraviolet (uv) transmission；
C) liquid；
D) saline solution；
E) aqueous metal salt；
F) aqueous metal salt, wherein the salt is selected from described group be made up of Na, K, Mg and combinations thereof；
G) non-aqueous solution；Or
H) gas.
18. a kind of method for being used to provide microorganism sterilizing on fluid matrix or solid matrix, comprises the following steps：
A) equipment for sterilising microbe is provided, wherein the equipment includes：
I. polychromatic source, it is used to produce polychromatic light；
Ii. optical device, it is positioned near the polychromatic source, wherein the optical device is configured as focusing on by described
Polychromatic light caused by polychromatic source is to provide about 0.01J/cm2To about 50.0J/cm2High-strength light output；The equipment includes：
A. dichroic reflector, wherein the dichroic reflector is configured as transmitting the heat energy generated by the polychromatic source；
And reflection polychromatic light as caused by the polychromatic source；
B. power supply, wherein the power supply is configured to coupled to the polychromatic source and the optical device；
B) the one predetermined time of polychromatic source is activated to provide the exposure cycle of greater than about 0.01 second；
D) output of equipment is positioned at away from the pending one predetermined distance of matrix；
F) surface to be treated is exported exposed to the high-strength light；And
G) inactivate the polychromatic source, so as to allow any microorganism agent present on the matrix to have sterilized.
19. the method according to claim 11, in addition to：
A) fluid core light guide of the positioning with first end, the second end and tubular body；And
B) wherein described light guide is positioned in optical device nearby and is connected with the first end near the optical device,
So that the high-strength light output is focused onto in the first end of the fluid core light guide and guided and passes through the tubulose
Body is led out in the matrix subject to sterilization towards second end and by second end.
20. according to the method for claim 18, wherein the exposure cycle is between about 0.01 second to about 5.0 seconds.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201514815519A | 2015-07-31 | 2015-07-31 | |
| US14/815,519 | 2015-07-31 | ||
| PCT/US2016/044798 WO2017023783A1 (en) | 2015-07-31 | 2016-07-29 | Systems and methods of microbial sterilization using polychromatic light |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107847620A true CN107847620A (en) | 2018-03-27 |
Family
ID=61683181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680044724.3A Pending CN107847620A (en) | 2015-07-31 | 2016-07-29 | Use heterogeneous light microorganism sterilizing system and method |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP3328445A4 (en) |
| CN (1) | CN107847620A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398294A (en) * | 2021-06-29 | 2021-09-17 | 上海科世达-华阳汽车电器有限公司 | Sterilization device in vehicle |
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| JPS5041908A (en) * | 1973-05-21 | 1975-04-16 | ||
| CN1270063A (en) * | 1999-03-01 | 2000-10-18 | 庄臣及庄臣视力保护公司 | Bactericidal method |
| CN1275890A (en) * | 1997-09-11 | 2000-12-06 | 坡里坡勒斯技术股份有限公司 | Apparatus for deactivating microorganisms |
| WO2001091810A1 (en) * | 2000-05-26 | 2001-12-06 | Purepulse Technologies, Inc. | Pulsed polychromatic light passthrough sterilization device |
| US20030086817A1 (en) * | 2001-11-06 | 2003-05-08 | Horton Isaac B. | Blood purification system |
| CN103948950A (en) * | 2005-08-31 | 2014-07-30 | 新技术水液规划公司 | Ultraviolet light treatment chamber |
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|---|---|---|---|---|
| US6447537B1 (en) * | 2000-06-21 | 2002-09-10 | Raymond A. Hartman | Targeted UV phototherapy apparatus and method |
| US20100222852A1 (en) * | 2009-02-24 | 2010-09-02 | Vasily David B | Apparatus and Method for Decolonizing Microbes on the Surfaces of the Skin and In Body Cavities |
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2016
- 2016-07-29 EP EP16833630.3A patent/EP3328445A4/en not_active Withdrawn
- 2016-07-29 CN CN201680044724.3A patent/CN107847620A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5041908A (en) * | 1973-05-21 | 1975-04-16 | ||
| CN1275890A (en) * | 1997-09-11 | 2000-12-06 | 坡里坡勒斯技术股份有限公司 | Apparatus for deactivating microorganisms |
| CN1270063A (en) * | 1999-03-01 | 2000-10-18 | 庄臣及庄臣视力保护公司 | Bactericidal method |
| WO2001091810A1 (en) * | 2000-05-26 | 2001-12-06 | Purepulse Technologies, Inc. | Pulsed polychromatic light passthrough sterilization device |
| US20030086817A1 (en) * | 2001-11-06 | 2003-05-08 | Horton Isaac B. | Blood purification system |
| CN103948950A (en) * | 2005-08-31 | 2014-07-30 | 新技术水液规划公司 | Ultraviolet light treatment chamber |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113398294A (en) * | 2021-06-29 | 2021-09-17 | 上海科世达-华阳汽车电器有限公司 | Sterilization device in vehicle |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3328445A4 (en) | 2018-07-04 |
| EP3328445A1 (en) | 2018-06-06 |
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| TA01 | Transfer of patent application right | ||
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Effective date of registration: 20180806 Address after: Church Street, Western Nashville, North Carolina Applicant after: Super Light Technology Co., Ltd. Address before: Raleigh, North Carolina, USA Applicant before: Kurt A Garrett |
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Address after: Church Street, Western Nashville, North Carolina Applicant after: Lumagannix Co., Ltd Address before: Church Street, Western Nashville, North Carolina Applicant before: Super Light Technology Co., Ltd. |
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