CN1078464A - Synthesizing method for bacteriostatic sulphur - Google Patents
Synthesizing method for bacteriostatic sulphur Download PDFInfo
- Publication number
- CN1078464A CN1078464A CN 93101799 CN93101799A CN1078464A CN 1078464 A CN1078464 A CN 1078464A CN 93101799 CN93101799 CN 93101799 CN 93101799 A CN93101799 A CN 93101799A CN 1078464 A CN1078464 A CN 1078464A
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- CN
- China
- Prior art keywords
- raw material
- sulfamonomethoxin
- bacteriostatic
- sulphur
- synthesizing method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention belongs to the sulfa technical field, it is a kind of synthesizing method for bacteriostatic sulphur, principal feature is to do initial raw material with malonic ester, acid amides, sodium alkoxide class industrial chemicals, through cyclization, chlorination, condensation, firstization, become salt refining and get, compare with existing Sulfamonomethoxin synthetic method, have the processing condition gentleness, raw material is easily purchased, actual recovery doubles, and cost reduces by 1/2, remarkable advantages such as no severe contamination.
Description
The invention belongs to the sulfa technical field, is a kind of about the Sulfamonomethoxin synthetic method.
Existing Sulfamonomethoxin synthetic method is to do butyl ethyl malonate earlier with several raw materials such as sodium cyanides, again with methane amide, sodium butylate through cyclization, chlorination, condensation, firstization, alkali analyse, purification step synthesizes, draw Sulfamonomethoxin, formal name used at school sulfanilamide (SN) 4-6 Sulfamonomethoxine, code name DS-36.Exist sodium butylate and need import, prussiate has severe toxicity, and the intermediate product cost is higher, and it is up to standard that fourth fat product is difficult for decolouring, uses shortcomings such as sodium salt method decolouring crystallization after need analysing with a large amount of liquid alkali alkali again.
The objective of the invention is to study a kind of method that adopts above-mentioned other raw material as the synthetic Sulfamonomethoxin of starting raw material.
The present invention adopts propanedioic acid lipid, amides, sodium alkoxide class industrial chemicals as starting raw material, and is synthetic through cyclization, chlorination, condensation, firstization, salify, crude product, step such as refining, obtains sulfanilamide (SN) 4-6 Sulfamonomethoxine, i.e. Sulfamonomethoxin.
Method in conjunction with the synthetic Sulfamonomethoxin of example explanation the present invention.
Starting raw material of the present invention adopts propanedioic acid lipid, amides, sodium alkoxide class to make raw material, as selecting for use propanedioic acid two formicesters, methane amide, sodium methylate as starting raw material, through cyclization, chlorination, condensation, firstization, salify, calcium salt method purification step.The calcium salt method treating process is that the salify crude product is added boiling water and lime, transfers pH value to heat up, and adds decolorizing with activated carbon, the neutralization that heats up again, and the cooling washing is taken off dried, draws Sulfamonomethoxin.
+ cao → → sulfanilamide (SN) 4-6 Sulfamonomethoxine.
This sulfamonomethoxine (SMM) synthetic method of the present invention is with existing sulfamonomethoxine (SMM) Synthetic method is compared, and has the process conditions gentleness, and raw material is easily purchased, and actual recovery doubles, and cost 1/2 does not have the remarkable advantages such as serious environmental pollution.
Claims (1)
1, Sulfamonomethoxin synthetic method is characterized in that using propanedioic acid fat, acid amides, sodium alkoxide class industrial chemicals as starting raw material, and through cyclization, chlorination, condensation, firstization, salify, calcium salt method are made with extra care and got.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101799 CN1078464A (en) | 1993-02-19 | 1993-02-19 | Synthesizing method for bacteriostatic sulphur |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101799 CN1078464A (en) | 1993-02-19 | 1993-02-19 | Synthesizing method for bacteriostatic sulphur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1078464A true CN1078464A (en) | 1993-11-17 |
Family
ID=4983788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93101799 Withdrawn CN1078464A (en) | 1993-02-19 | 1993-02-19 | Synthesizing method for bacteriostatic sulphur |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1078464A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054127C (en) * | 1996-07-16 | 2000-07-05 | 中国医药研究开发中心 | Process for preparing monohydrate of sulfamonomethoxine |
| CN102391190A (en) * | 2011-09-30 | 2012-03-28 | 常熟市金申医化制品有限责任公司 | Method for preparing sulfadoxine |
| CN105294577A (en) * | 2015-11-23 | 2016-02-03 | 和夏化学(太仓)有限公司 | Preparation method for sulfanilamide-6-methoxypyrimidine |
-
1993
- 1993-02-19 CN CN 93101799 patent/CN1078464A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054127C (en) * | 1996-07-16 | 2000-07-05 | 中国医药研究开发中心 | Process for preparing monohydrate of sulfamonomethoxine |
| CN102391190A (en) * | 2011-09-30 | 2012-03-28 | 常熟市金申医化制品有限责任公司 | Method for preparing sulfadoxine |
| CN105294577A (en) * | 2015-11-23 | 2016-02-03 | 和夏化学(太仓)有限公司 | Preparation method for sulfanilamide-6-methoxypyrimidine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C03 | Withdrawal of patent application (patent law 1993) | ||
| WW01 | Invention patent application withdrawn after publication |