CN107837309A - A kind of composition with auxiliary hyperglycemic function and preparation method thereof - Google Patents

A kind of composition with auxiliary hyperglycemic function and preparation method thereof Download PDF

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CN107837309A
CN107837309A CN201710820373.7A CN201710820373A CN107837309A CN 107837309 A CN107837309 A CN 107837309A CN 201710820373 A CN201710820373 A CN 201710820373A CN 107837309 A CN107837309 A CN 107837309A
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parts
root
ginseng
rehmannia
radix astragali
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CN107837309B (en
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蔡向杰
屈云萍
姜国志
刘艳丽
李菲
王娇
李哲
高杰
李振江
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Beijing Tianjin Hebei LIAN pharmaceutical research (Beijing) Co., Ltd.
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Shenwei Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention relates to a kind of composition with auxiliary hyperglycemic function and preparation method thereof, said composition is prepared by 5 70 parts of ginseng, 10 80 parts of the Radix Astragali, 300 1500 parts of balsam pear, 5 80 parts of the dried rhizome of rehmannia, 5 70 parts of Fructus Corni, 5 80 parts of the root of kudzu vine for primary raw material, and its preparation method can include：Ginseng, the Radix Astragali, the taste traditional Chinese medicine extraction of the dried rhizome of rehmannia three are concentrated and spray into fine powder, and the root of kudzu vine, Fructus Corni extraction are concentrated and spray into fine powder, and after filtering of squeezing the juice powder processed is dried respectively in filtrate and filter residue by balsam pear, and all fine powders are well mixed into the steps such as pelletizing press sheet.The present composition has more preferable effect compared with using the composition of other proportioning preparations of homogeneous raw material, while than traditional Western medicine compound compared to also with close or more preferable effect.

Description

A kind of composition with auxiliary hyperglycemic function and preparation method thereof
Technical field
The present invention relates to health food and medicine field, and in particular to a kind of composition with auxiliary hyperglycemic function and Its preparation method.
Background technology
Diabetes are a kind of common disease, frequently-occurring disease, can betide any age bracket, and its number of patients is with people's lives water Flat raising, the aging of population, living-pattern preservation and improving for diagnostic techniques and increase sharply, diabetes mellitus in China is suffered from present For person's number up to more than 97,000,000, quantity reaches the first in the world.Diabetes turn into a kind of 21 century worldwide epidemic disease. It is the Chronic Non-Communicable Diseases of the third-largest serious threat human health after tumour, vascular lesion, turns into our times The public health problem that various countries face jointly.
The etiology and pathogenesis of diabetes is asthenia in origin and asthenia in superficiality.Using deficiency of both qi and yin to be common, according to the etiology and pathogenesis of diabete, with the moon Void is this, scorching to mark, and with the passing of time, healthy tendency is damaged, yin deficiency affecting yang, it is seen that impairment of both QI and YIN or deficiency in both YIN and YANG for delay.Lesion internal organs with Lung, stomach (spleen), based on kidney, among three, though having laid particular stress on, but influence each other more, therapy when based on benefiting qi and nourishing yin, and with Supplemented by clearing heat and promoting fluid is taken stopgap measures, giving consideration to both the incidental and fundamental, benefiting qi and nourishing yin promotes the production of body fluid, and gas Tianjin is unimpeded, and all diseases must subtract.
Ginseng reinforces vital energy, reinforces the spleen to benefit the lung, slaked thirst and help produce saliva in this product；Radix Astragali invigorating qi for strengthening superficies；Balsam pear can let out the six channels excess fire, Clear heat, improving eyesight, control pyreticosis polydipsia；Dried rhizome of rehmannia clearing heat and cooling blood, nourishing Yin and promoting production of body fluid；Fructus Corni tonifies the liver and kidney, puckery smart prevent prolapse；Root of kudzu vine liver is light, It is nontoxic, except heat, quench the thirst；Quan Fangzhong is reinforced the spleen to benefit the lung with ginseng, the Radix Astragali, nourishing generate fluid；Balsam pear, dried rhizome of rehmannia clearing heat-fire, nourishing Yin and promoting production of body fluid； Fructus Corni tonifies the liver and kidney；The root of kudzu vine promotes the production of body fluid to quench thirst；All tastes share and play supplementing qi and nourishing yin altogether, the effect of clearing heat and promoting fluid.
Modern pharmacological research shows：Contain a variety of blood-sugar decreasing actives in ginseng, ginsenoside can significantly improve serum Insulin, blood glucose is reduced, increase SOD contents, it is horizontal to reduce LPO；To hyperglycaemia with effect is significantly reduced, it drops panaxan Sugar effect is slightly below insulin, there is obvious dose-effect relationship.The Radix Astragali has oxidation resistance, the cell knot to keeping beta Cell of islet Structure is complete, maintains normal physiological function important role, so as to ensure that the link work(such as the synthesis of β cells, uelralante Can be normal；Astragaloside can promote the secretion of diabetes rat insulin, blood glucose be reduced, so as to contribute to the treatment of diabetes； In addition, the Radix Astragali is also possible to the secretion by stimulating class glucagon peptide 1 (GLP 1), insulin granule in beta Cell of islet is induced The recovery of activity, increases insulin secretion, so as to prevent the generation of diabetes in a sense.Balsam pear soap in balsam pear Glycosides and bitter melon protein, not only there is the function of similar insulin, and β cells secrete insulins can be stimulated, correlative study is shown Its extract has obvious association reaction with insulin receptor, insulin antibody, shows that it is known as common antigen with pancreas islet Property and bioactivity.Fructus Corni can reduce blood glucose, improve immunity of organism, and Wheat Protein.Rehmanin in the dried rhizome of rehmannia has Reduce blood glucose effect, and energy Inhibition test hyperglycaemia, moreover it is possible to stimulate the secretion of insulin, Rehmannia glutinosa oligosaccharide can obviously reduce blood Sugar, it can also reduce G-6-Pase activity.Puerarin has obvious hypoglycemic effect to alloxan hyperglycaemia, can change Kind sugar tolerance, also has blood sugar reducing function to adrenal gland disposition hyperglycaemia.
In summary, Quan Fangzhong contains ginseng, the Radix Astragali and a variety of saponin(es of balsam pear and Rehmannia glutinosa oligosaccharide, Puerarin isoreactivity Composition, acted synergistically the effect of reaching auxiliary hyperglycemic jointly by various active composition.
The content of the invention
The primary and foremost purpose of the present invention is to provide a kind of new composition for having auxiliary hyperglycemic function.
To achieve these goals, the composition includes the component of following parts by weight：Ginseng 5-70 parts, Radix Astragali 10-80 Part, balsam pear 300-1500 parts, dried rhizome of rehmannia 5-80 parts, Fructus Corni 5-70 parts, root of kudzu vine 5-80 parts.
As further preferred scheme：Composition of the present invention includes the component of following parts by weight：Ginseng 10-50 Part, Radix Astragali 20-70 parts, balsam pear 500-1200 parts, dried rhizome of rehmannia 10-70 parts, Fructus Corni 10-60 parts, root of kudzu vine 10-70 parts.
As further preferred scheme：Composition of the present invention includes the component of following parts by weight：Ginseng 10-40 Part, Radix Astragali 30-60 parts, balsam pear 700-1200 parts, dried rhizome of rehmannia 20-60 parts, Fructus Corni 20-50 parts, root of kudzu vine 10-50 parts.
A preferred embodiment of the present invention：Composition of the present invention includes the component of following parts by weight：15 parts of ginseng, Huang 30 parts of stilbene, 1000 parts of balsam pear, 30 parts of the dried rhizome of rehmannia, 40 parts of Fructus Corni, 40 parts of the root of kudzu vine.
A preferred embodiment of the present invention：Composition of the present invention includes the component of following parts by weight：20 parts of ginseng, Huang 60 parts of stilbene, 1100 parts of balsam pear, 60 parts of the dried rhizome of rehmannia, 50 parts of Fructus Corni, 50 parts of the root of kudzu vine.
A preferred embodiment of the present invention：Composition of the present invention includes the component of following parts by weight：30 parts of ginseng, Huang 45 parts of stilbene, 900 parts of balsam pear, 45 parts of the dried rhizome of rehmannia, 30 parts of Fructus Corni, 30 parts of the root of kudzu vine.
In a kind of technical scheme of the present invention, present composition preparation method comprises the following steps：By said ratio Weigh balsam pear squeeze the juice filtering after filtrate concentration, filter residue powder；With ginseng, the Radix Astragali, the dried rhizome of rehmannia, Fructus Corni, root of kudzu vine traditional Chinese medicine of the five flavours, mixing After crush, or crush after be mixed to get.
In a kind of technical scheme of the present invention, present composition preparation method comprises the following steps：By said ratio Weigh balsam pear squeeze the juice filtering after filtrate concentration, filter residue powder；Ginseng, the Radix Astragali, the dried rhizome of rehmannia, Fructus Corni, root of kudzu vine traditional Chinese medicine of the five flavours are carried Concentration powder is taken, is mixed with and forms.
In a kind of technical scheme of the present invention, present composition preparation method comprises the following steps：By said ratio Weigh balsam pear squeeze the juice filtering after filtrate concentration, filter residue powder；The step of ginseng, the Radix Astragali, the dried rhizome of rehmannia, Fructus Corni, root of kudzu vine traditional Chinese medicine of the five flavours, The step of preparing ginseng extract, the step of preparing Astragalus Root P.E, the step of preparing dried rhizome of rehmannia extract, prepare Fructus Corni extraction The step of thing, the step of preparing kudzu root extract and by above-mentioned ginseng extract, Astragalus Root P.E, dried rhizome of rehmannia extract, mountain Zhu The step of cornel extract, kudzu root extract mixing.
As further preferred scheme：Present composition preparation method comprises the following steps：
(1) balsam pear squeeze the juice filtering after filtrate concentration, filter residue powder；
(2) ginseng, the Radix Astragali, the dried rhizome of rehmannia concentrate powder processed through water extract-alcohol precipitation；
(3) root of kudzu vine, Fructus Corni concentrate powder processed through alcohol extracting；
(4) it is step (1), step (2) and step (3) is well mixed.
It is another object of the present invention to provide a kind of new oral formulations for having auxiliary hyperglycemic function.
To achieve these goals, present invention employs following technical scheme：Ginseng 5-70 parts, Radix Astragali 10-80 parts, balsam pear 300-1500 parts, dried rhizome of rehmannia 5-80 parts, Fructus Corni 5-70 parts, root of kudzu vine 5-80 parts, are mixed together with pharmaceutic adjuvant, make according to a conventional method It is standby into oral formulations.Hard capsule, soft capsule, tablet, granule, powder, pill, bag are preferably prepared in some versions One kind in making tea.
As optimal technical scheme, the present composition is made from the following raw materials in parts by weight：Ginseng 10-50 parts, Radix Astragali 20-70 parts, balsam pear 500-1200 parts, dried rhizome of rehmannia 10-70 parts, Fructus Corni 10-60 parts, root of kudzu vine 10-70 parts, with pharmaceutic adjuvant one Mixing is played, is prepared into oral formulations according to a conventional method.Be preferably prepared in some versions hard capsule, soft capsule, tablet, One kind in granule, powder, pill, tea bag.
As optimal technical scheme, the present composition is made from the following raw materials in parts by weight：Ginseng 10-40 parts, Radix Astragali 30-60 parts, balsam pear 700-1200 parts, dried rhizome of rehmannia 20-60 parts, Fructus Corni 20-50 parts, root of kudzu vine 10-50 parts, with pharmaceutic adjuvant one Mixing is played, is prepared into oral formulations according to a conventional method.Be preferably prepared in some versions hard capsule, soft capsule, tablet, One kind in granule, powder, pill, tea bag.
As optimal technical scheme, the present composition is made from the following raw materials in parts by weight：15 parts of ginseng, the Radix Astragali 30 parts, 1000 parts of balsam pear, 30 parts of the dried rhizome of rehmannia, 40 parts of Fructus Corni, 40 parts of the root of kudzu vine, be mixed together with pharmaceutic adjuvant, make according to a conventional method It is standby into oral formulations.Hard capsule, soft capsule, tablet, granule, powder, pill, bag are preferably prepared in some versions One kind in making tea.
As optimal technical scheme, the present composition is made from the following raw materials in parts by weight：20 parts of ginseng, the Radix Astragali 60 parts, 1100 parts of balsam pear, 60 parts of the dried rhizome of rehmannia, 50 parts of Fructus Corni, 50 parts of the root of kudzu vine, be mixed together with pharmaceutic adjuvant, make according to a conventional method It is standby into oral formulations.Hard capsule, soft capsule, tablet, granule, powder, pill, bag are preferably prepared in some versions One kind in making tea.
As optimal technical scheme, the present composition is made from the following raw materials in parts by weight：30 parts of ginseng, the Radix Astragali 45 parts, 900 parts of balsam pear, 45 parts of the dried rhizome of rehmannia, 30 parts of Fructus Corni, 30 parts of the root of kudzu vine, be mixed together with pharmaceutic adjuvant, make according to a conventional method It is standby into oral formulations.Hard capsule, soft capsule, tablet, granule, powder, pill, bag are preferably prepared in some versions One kind in making tea.
As optimal technical scheme, the preparation method of the above-mentioned oral formulations of the present invention comprises the following steps：
(1) balsam pear squeeze the juice filtering after filtrate concentration, filter residue powder；
(2) ginseng, the Radix Astragali, the dried rhizome of rehmannia concentrate powder processed through water extract-alcohol precipitation；
(3) root of kudzu vine, Fructus Corni concentrate powder processed through alcohol extracting；
(4) it is step (1), step (2) and step (3) is well mixed；
(5) mixture that step (4) obtains is mixed with pharmaceutic adjuvant, oral formulations is made according to a conventional method.
Third object of the present invention is to provide a kind of tablet with auxiliary hyperglycemic function.
In order to better illustrate technical scheme, there is provided following technical scheme should not be seen as pair as reference The limitation of the present invention：
Ginseng 5-70 parts, Radix Astragali 10-80 parts, balsam pear 300-1500 parts, dried rhizome of rehmannia 5-80 parts, Fructus Corni 5-70 parts, root of kudzu vine 5- 80 parts, it is mixed together with pharmaceutic adjuvant, prepares piece agent according to a conventional method.In some embodiments, the tablet is prepared Pharmaceutic adjuvant preferably comprises microcrystalline cellulose, Aspartame, magnesium stearate.Wherein, as optimal technical scheme：Prepare above-mentioned The pharmaceutic adjuvant weight proportion of invention tablet is microcrystalline cellulose 1-30 parts, Aspartame 0.1-10 parts, magnesium stearate 1-5 parts.
As optimal technical scheme, the present invention provides following technical scheme：Ginseng 10-50 parts, Radix Astragali 20-70 parts, balsam pear 500-1200 parts, dried rhizome of rehmannia 10-70 parts, Fructus Corni 10-60 parts, root of kudzu vine 10-70 parts.It is mixed together with pharmaceutic adjuvant, routinely side Method prepares piece agent.In some embodiments, the pharmaceutic adjuvant for preparing the tablet preferably comprises microcrystalline cellulose, A Siba Sweet tea, magnesium stearate.Wherein, as optimal technical scheme：The pharmaceutic adjuvant weight proportion for preparing the invention described above tablet is crystallite Cellulose 5-20 parts, Aspartame 0.2-8 parts, magnesium stearate 0.2-3 parts.
As optimal technical scheme, Tablets provide following technical scheme：Ginseng 10-40 parts, Radix Astragali 30-60 parts, Balsam pear 700-1200 parts, dried rhizome of rehmannia 20-60 parts, Fructus Corni 20-50 parts, root of kudzu vine 10-50 parts.It is mixed together with pharmaceutic adjuvant, by normal Rule method prepares piece agent.In some embodiments, prepare the tablet pharmaceutic adjuvant preferably comprise microcrystalline cellulose, Ah This Ba Tian, magnesium stearate.Wherein, as optimal technical scheme：Prepare the invention described above tablet pharmaceutic adjuvant weight proportion be Microcrystalline cellulose 10-15 parts, Aspartame 0.5-3 parts, magnesium stearate 0.3-2 parts.
As optimal technical scheme, Tablets provide following technical scheme：15 parts of ginseng, 30 parts of the Radix Astragali, balsam pear 1000 parts, 30 parts of the dried rhizome of rehmannia, 40 parts of Fructus Corni, 40 parts of the root of kudzu vine.It is mixed together with pharmaceutic adjuvant, prepares piece agent according to a conventional method. In some embodiments, the pharmaceutic adjuvant for preparing the tablet preferably comprises microcrystalline cellulose, Aspartame, magnesium stearate. Wherein, as optimal technical scheme：Prepare the invention described above tablet pharmaceutic adjuvant weight proportion for 15 parts of microcrystalline cellulose, Ah 0.6 part of this Ba Tian, 0.4 part of magnesium stearate.
As optimal technical scheme, Tablets can use following technical scheme：20 parts of ginseng, 60 parts of the Radix Astragali, hardship 1100 parts of melon, 60 parts of the dried rhizome of rehmannia, 50 parts of Fructus Corni, 50 parts of the root of kudzu vine.It is mixed together, is prepared according to a conventional method in flakes with pharmaceutic adjuvant Agent.In some embodiments, when preparing the pharmaceutic adjuvant of the tablet comprising microcrystalline cellulose, Aspartame, magnesium stearate Superior technique effect can be obtained.Wherein, auxiliary material weight proportion is 15 parts of microcrystalline cellulose, 0.6 part of Aspartame, tristearin Sour this technical scheme effect of 0.4 part of magnesium is more excellent.
Alternatively, Tablets can also use following technical scheme：30 parts of ginseng, 45 parts of the Radix Astragali, 900 parts of balsam pear, 45 parts of the dried rhizome of rehmannia, 30 parts of Fructus Corni, 30 parts of the root of kudzu vine.It is mixed together, is prepared according to a conventional method in flakes with pharmaceutic adjuvant Agent.In some embodiments, the pharmaceutic adjuvant for preparing the tablet preferably comprises microcrystalline cellulose, Aspartame, stearic acid Magnesium.Wherein, as optimal technical scheme：The pharmaceutic adjuvant weight proportion for preparing the invention described above tablet is microcrystalline cellulose 15 Part, 0.6 part of Aspartame, 0.4 part of magnesium stearate.
The preparation method of the above-mentioned tablet of the present invention comprises the following steps：
(1) balsam pear squeeze the juice filtering after filtrate concentration, filter residue powder；
(2) ginseng, the Radix Astragali, the dried rhizome of rehmannia concentrate powder processed through water extract-alcohol precipitation；
(3) root of kudzu vine, Fructus Corni concentrate powder processed through alcohol extracting；
(4) it is step (1), step (2) and step (3) is well mixed.
(5) by mixture obtained by microcrystalline cellulose, Aspartame and step (4) through pelletizing, drying, stiffened fatty acid magnesium pressure Piece, obtain tablet.
As more preferably technical scheme：The preparation method for preparing the invention described above tablet comprises the following steps：
(1) weigh balsam pear to squeeze the juice, filter, filtrate keeps negative pressure to be concentrated under reduced pressure into relative density about in more than 0.08Mpa 1.30-1.40 thick paste is standby；Ultramicro grinding is fine powder after filter residue low temperature drying.
(2) ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed to put in extractor, adds 5-10 times of water refluxing extraction 1-3 times, each 0.5-2h, mistake Filter, merging filtrate, concentration, adding ethanol makes alcohol content reach 40-60%, 10 DEG C of stand at low temperature 8-36h, Aspirate supernatant mistake Filter, be concentrated under reduced pressure into medicinal extract, it is spray-dried that fine powder is made.
(3) weigh the root of kudzu vine, Fructus Corni is put in extractor, add 4-8 times measure 40%-70% alcohol refluxs extract 1-3 times, often Secondary extraction 0.5-3h, filtering, merging filtrate, ethanol is reclaimed, is concentrated into medicinal extract, it is spray-dried into fine powder.
(4) it is step (1) (2) (3) is well mixed.
(5) by mixture obtained by microcrystalline cellulose, Aspartame and step (4) through 30-80% alcohol granulations, 20-80 DEG C Dry, stiffened fatty acid magnesium tabletting obtains tablet.
Fourth object of the present invention is that provide a kind of composition of the present invention has auxiliary hyperglycemic function in preparation Medicine or health products in application, preferably prepare prevention and treatment diabetes medicine or health products in application.
The 5th purpose of the present invention is that provide a kind of tablet of the present invention has auxiliary hyperglycemic function in preparation Application in medicine or health products, the preferably application in the medicine or health products for preparing prevention and treatment diabetes.
Composition of the present invention shows to significantly reduce on an empty stomach and postprandial plasma glucose level, while to high blood through zoopery The cardinal symptoms such as sugared crowd eats more, more drink, diuresis, fatigue and weaks have a better role.
Specific embodiment
Following is in conjunction with specific embodiments and experimental example, the present invention to be expanded on further.But these embodiments and experimental example are only It is limited to illustrate rather than for limiting the scope of the present invention.
First, embodiment is prepared
Embodiment 1
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 2
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 3
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 4
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 5
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 6
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 7
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 8
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 9
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 10
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 11
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 12
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia, the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, mixing, crush, cross 80 mesh sieves, obtaining ginseng, Huang Stilbene, the dried rhizome of rehmannia, the root of kudzu vine, Fructus Corni composition.
Embodiment 13
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 14
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 15
Prescription：
Preparation method：
After balsam pear is weighed up by recipe quantity, cleaning, remove seed, squeeze the juice, filter, filtrate keeps negative pressure to be depressurized in more than 0.08MPa The thick paste of relative density about 1.30~1.40 is concentrated into, spray-dried, crushing, obtains balsam pear dried cream powder after crossing 80 mesh sieves；Filter residue Ultramicro grinding obtains Bitter Melon P.E after low temperature drying.
After ginseng, the Radix Astragali, the dried rhizome of rehmannia are weighed up by recipe quantity, respectively plus 10 times of amounts, 8 times of amount water (m/m) refluxing extractions are secondary, often Secondary two hours, merge extract solution, filtering, filtrate decompression is concentrated into suitable density about 1.25~1.35, and adding ethanol makes alcohol content Reach 70%, 10 DEG C or so stand at low temperature 24 hours, Aspirate supernatant filtering, filtrate keeps negative pressure to be depressurized in more than 0.06Mpa Recovery ethanol is simultaneously concentrated into relative density about 1.10~1.20, spray drying, crushes, crosses 80 mesh sieves, obtaining the ginseng Radix Astragali dried rhizome of rehmannia and carry Take thing.
After the root of kudzu vine, Fructus Corni are weighed up by recipe quantity, respectively plus 8 times of amounts, 6 times of amount 60% ethanol (v/m) refluxing extractions are secondary, Two hours every time, merge extract solution, filtering, ethanol is recovered under reduced pressure in more than 0.06Mpa in filtrate holding negative pressure and is concentrated into phase To density about 1.10~1.20, spray-dried, crushing, 80 mesh sieves are crossed, obtain root of kudzu vine cornel extractive.
Balsam pear dried cream powder, Bitter Melon P.E, ginseng Radix Astragali cornel extractive and root of kudzu vine cornel extractive are mixed equal It is even to produce the present composition.
Embodiment 16
The present composition that embodiment 15 obtains is pulverized and sieved, adds 100g microcrystalline celluloses and 4g magnesium stearates, is mixed It is bonded to uniformly, pours into capsule, capsule is made.
Embodiment 17
The present composition that embodiment 15 obtains is pulverized and sieved, adds 16.5g microcrystalline celluloses, 0.64g Aspartames With 0.4g magnesium stearates, mix to uniform, tabletting, tablet is made.
Embodiment 18
The present composition that embodiment 15 obtains is pulverized and sieved, adds 6g dextrin, is mixed to uniform, granulation is made Granula.
Embodiment 19
The present composition that embodiment 15 obtains is pulverized and sieved, adds 10g starch and 5g honey, is mixed to uniform, system Ball, pill is made.
Embodiment 20
The present composition that embodiment 15 obtains is pulverized and sieved, mixes to uniform, divides pouch-packaged, powder is made.
Embodiment 21
24.8g microcrystalline celluloses and 0.96g Aspartames are weighed, adds the present composition that embodiment 1 obtains, mixing Uniformly, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 0.6g magnesium stearates are added, in automatic tableting press Upper tabletting, is packed after the assay was approved, obtains tablet.
Embodiment 22
22.5g microcrystalline celluloses and 3.21g Aspartames are weighed, adds the present composition that embodiment 1 obtains, mixing Uniformly, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 0.6g magnesium stearates are added, in automatic tableting press Upper tabletting, is packed after the assay was approved, obtains tablet.
Embodiment 23
21g microcrystalline celluloses and 0.75g Aspartames are weighed, adds the present composition that embodiment 1 obtains, mixing is equal It is even, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 0.3g magnesium stearates are added, on automatic tableting press Tabletting, pack after the assay was approved, obtain tablet.
Embodiment 24
21.7g microcrystalline celluloses and 1.18g Aspartames are weighed, adds the present composition that embodiment 4 obtains, mixing Uniformly, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 1.54g magnesium stearates are added, in automatic tabletting Tabletting on machine, is packed after the assay was approved, obtains tablet.
Embodiment 25
22.3g microcrystalline celluloses and 0.5g Aspartames are weighed, adds the present composition that embodiment 4 obtains, mixing Uniformly, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 0.84g magnesium stearates are added, in automatic tabletting Tabletting on machine, is packed after the assay was approved, obtains tablet.
Embodiment 26
21.4g microcrystalline celluloses and 0.62g Aspartames are weighed, adds the present composition that embodiment 4 obtains, mixing Uniformly, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 2.52g magnesium stearates are added, in automatic tabletting Tabletting on machine, is packed after the assay was approved, obtains tablet.
Embodiment 27
13.8g microcrystalline celluloses and 0.58g Aspartames are weighed, adds the present composition that embodiment 7 obtains, mixing Uniformly, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 1.4g magnesium stearates are added, in automatic tableting press Upper tabletting, is packed after the assay was approved, obtains tablet.
Embodiment 28
20g microcrystalline celluloses and 0.9g Aspartames are weighed, adds the present composition that embodiment 2 obtains, mixing is equal It is even, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, 0.6 magnesium stearate is added, on automatic tableting press Tabletting, pack after the assay was approved, obtain tablet.
Embodiment 29
10.9g microcrystalline celluloses and 0.66g Aspartames are weighed, adds the present composition that embodiment 11 obtains, is mixed Close uniform, add ethanol and suitable softwood is made, pelletize, then cross 14 mesh sieve whole grains, add 0.77g magnesium stearates, from dynamic pressure Tabletting on piece machine, is packed after the assay was approved, obtains tablet.
Part II toxicity and pharmacodynamic experiment
Test example 1, toxicological experiment
1st, acute toxicity test in mice：Test specimen：Capsule prepared by embodiment 16；From cleaning grade Kunming mouse 20,18-22 grams of body weight, male and female half and half, tested by MTD methods.Maximum dose level be 15000mg/kgbw (using distilled water as Solvent, similarly hereinafter), using disposable gavage in isometric administration by gavage (0.2ml/10gbw) 24 hours, Continuous Observation two weeks.Note Record poisoning manifestations and death condition.
2nd, rat acute toxicity test：Test specimen：Tablet made from embodiment 28；From cleaning grade SD rats 20, 180-220 grams of body weight, male and female half and half, tested by MTD methods.Maximum dose level is 15000mg/kgbw, is filled using isometric Disposable gavage in stomach method (2ml/10gbw) 24 hours, Continuous Observation two weeks.Record poisoning manifestations and death condition.
3rd, genetic toxicity test：
Test specimen：Tablet made from embodiment 23
(1) Salmonella reversion test：This experiment uses flat board incorporation methods, is divided to plus with being not added with two kinds of S9 mixed liquors.Dosage is respectively 0.005th, 0.025,0.250,1.000,5.000mg/ wares, separately set blank control, solvent control distilled water, 0.1ml/ wares.Sun Property control group using 2-AF20 μ g/ wares, 2,4,7-TNFonelug/ wares, NaN32.5 μ g/ wares, the μ g/ wares of mitomycin C 4.0,1, The μ g/ wares of 8- dihydroxy anthraquinones 50, each dosage group make three plates, and repetition is done twice.Strain is T A97 (a), T A98, T Tetra- plants of A100, T A102 bacterium.
(2) PCEMNR micronucleus (MNPCE) is tested：From cleaning grade Kunming mouse 50, body weight 25-30 grams, it is randomly divided into five groups, every group 10, male and female half and half；If three dosage groups：2500th, 5000,10000mg/kg bodies Weight, while sets negative control group (distilled water) and positive controls (CP40mg/kg), and each group is spaced 24 hours twice to sample, Bone marrow of sternum film-making was taken to 6 hours after sample using isometric administration by gavage (0.2ml/10gbw) for the second time, every animal counts 1000 polychromatic erythrocytes, calculate wherein microkernel incidence.
(3) mouse inbred strain：From cleaning grade Male Kunming strain mice 25,30-35 grams of body weight, it is randomly divided into Five groups, every group five；If three dosage groups：2500th, 5000,10000mg/kg body weight, while set negative control group (distilled water) It is continuous orally to give sample 5 days with positive controls (CP40mg/kg).Animal is put to death to sample meter within the 35th day, take bilateral epididymal from first Film-making, every animal count 1000 sperms, calculate abnormal rate.
(4) 30 days feeding trials：From cleaning grade SD rats 80, body weight 60-80g, four groups, every group 20 are randomly divided into Only.Male and female half and half, single cage raising.Tested material sets three test doses, respectively 8.0g/kg body weight, 4.0g/kg body weight, 2.0g/kg body weight (100 times of high dose equivalent to recommended amounts), tested material is incorporated into basal feed respectively and is fed with, continuously 30 days.Rat daily inleting appetite calculates by the 10% of its body weight, and contained tested material is respectively 8.0%, 4.0%, 2.0% in feed. Negative control group is fed with basal feed, the equal ad lib of each group animal and drinking-water during nursing, claims mouse body weight weekly and records feeding Expect consumption once, experiment latter stage adopts tail blood and carries out hematology and biochemical analysis.Observation index have body weight, food utilization, Hematological examination (being determined using blood counting instrument), biochemical analysis are (raw using corresponding reagent box and automatically after separation serum Change analysis-e/or determining), experiment latter stage puts to death rat, and solution takes liver,spleen,kidney, testis (ovary) is weighed, and calculates organ coefficient, so Histopathological examination (paraffin section) is carried out to liver,kidney,spleen, stomach, intestines, testis (ovary) afterwards.
It is above-mentioned test result indicates that, the present composition is all higher than 15000mg/ to the MTD of the large and small mouse of two kinds of sexes Kgbw, illustrate product nontoxicity；Three mutagenicity test results are negative；30 days feeding trial indices of rat are without bright It is aobvious abnormal.
The present composition of test example 2 is tested auxiliary hyperglycemic action function
This experiment uses the tablet that sample is prepared for embodiment 25.
Kunming mouse is chosen, male Body Weight 24-26g, is provided by Hebei province's Experimental Animal Center.Animal quality certification number： SCXK (Ji) 2003-1-003.
Dosage choice：Product human body recommended amounts are 4.8g/ days/60kgbw, and the dose,equivalent of mouse pushes away equivalent to human body 10 times of the amount of recommending, i.e., daily ingestion of 0.8g/kgbw be low dosage, then respectively set a metering group by 2 times of low dosage and 3 times, That is 1.6/kgbw (middle dosage) and 2.4g/kgbw (high dose), control group to distilled water, daily isometric gavage once, After giving tested material 30 days, indices are determined.
Experimental method：(1) to the influence of normal mouse fasting blood-glucose
It is grouped by fasting 3h mouse blood sugar value, it is control group to select 1 at random, and 1 is high dose group, and every group 10 dynamic Thing.Continuously give tested material 30 days, fasting blood sugar is surveyed after last gavage 0.5h.
(2) to the influence of alloxan diabetes model mice fasting blood-glucose
43mg/kgbw alloxans are given through tail vein after animal fasting 24h, the 7th day fasting 4h, survey blood glucose value, choosing The mouse for taking blood glucose value 10-25mmol/L is hyperglycemia model mouse.Four groups are randomly divided into, wherein 1 model control group, 3 dosage groups, every group of equal 11 mouse (control group is to distilled water).Each dosage group continuously gives tested material 30 days, is filled in last Fasting blood sugar is surveyed after stomach 0.5h.
(3) to the influence of alloxan diabetes model mice sugar tolerance
43mg/kgbw alloxans are given through tail vein after animal fasting 24h, the 7th day fasting 4h, survey blood glucose value, choosing The mouse for taking blood glucose value 10-25mmol/L is hyperglycemia model mouse.Four groups are randomly divided into, wherein 1 model control group, 3 dosage groups, every group of equal 11 mouse (control group is to distilled water).Each dosage group continuously gives tested material 30 days, is filled in last Oral administration of glucose 2.0g/kgbw after stomach 15-20min, measure 0,0.5,2h blood glucose value.
Result is examined using t and carries out statistical disposition.
Influence to hyperglycemia model mouse weight is shown in Table 1.
The each group mouse original body mass of table 1, mid-term body weight, latter stage body weight (g)
Dosage (g/kgbw) Animal (only) Original body mass Animal (only) Mid-term body weight Animal (only) Terminate body weight
Model comparison 11 26.4±0.96 11 28.1±1.8 11 29.9±2.4
Low (0.8) 11 26.5±1.27 11 28.3±1.8 11 30.0±3.5
In (1.6) 11 26.3±1.44 11 28.4±1.5 11 30.2±3.4
High (2.4) 11 26.7±0.85 11 28.2±1.1 11 29.7±2.9
As can be seen from Table 1, the product of orally administration mouse various dose 30 days, the body weight of each experimental mice is with compareing Group is compared to there was no significant difference (P ＞ 0.05).
Influence to normal mouse fasting blood-glucose：It is shown in Table 2.
Influence of the table 2 to normal mouse fasting blood-glucose
As can be seen from Table 2, the product of the normal high dose of orally administration 30 days, before the fasting blood-glucose change and administration of mouse Compare that there was no significant difference (P ＞ 0.05).
Influence to hyperglycaemia mice serum fasting blood-glucose：It is shown in Table 3
Influence of the table 3 to hyperglycaemia mouse fasting blood-glucose
As can be seen from Table 3, the product of orally administration mouse various dose 30 days, the fasting blood sugar of high dose group mouse Significantly lower than the fasting blood sugar (P ＜ 0.05) of model control group.
Influence to hyperglycemia model glucose tolerance in mice：It is shown in Table 4
Influence of the table 4 to hyperglycemia model glucose tolerance in mice
With model control group ratio * * P ＜ 0.01*P ＜ 0.05
From table 4, the product of orally administration mouse various dose 30 days, to each dosage group mouse 2.0g/kgbw Portugals Grape sugar, the middle and high dosage group of 0.5h and 2h blood glucose values are substantially less than model control group (P ＜ 0.05, P ＜ 0.01).
Influence to hyperglycaemia glucose tolerance in mice：It is shown in Table 5
Influence of the table 5 to hyperglycemia model mouse TG-AUC
As can be seen from Table 5, the product of orally administration mouse various dose 30 days, can from sugar tolerance experimental result Go out, middle dose group and high dose group TG-AUC are obvious compared with control group to be reduced, difference be respectively provided with conspicuousness (P ＜ 0.05, P ＜ 0.01).
The function of reducing blood sugar human experiment experiment of the present invention of test example 3
Experiment uses the tablet that sample is prepared for embodiment 28.
1st, subject selects：Selection state of an illness after diet control or OHA treatment is relatively stable, it is not necessary to more dressing Article kind and dosage, only take the adult type ii diabetes patient of maintenance dose, fasting blood-glucose >=7.8mmol/L (140mg/dl) or 2h-plasma glucose >=11.1mmol/L (200mg/dl)；Also 7.8mmol/L >=fasting blood-glucose >=6.7mmol/L may be selected (120mg/dl) or 11.1mmol/L (200mg/dl) >=2h-plasma glucose >=7.8mmol/L hyperglycemia population.Subject without The complication of the main organs such as the heart, liver, kidney, hepatic and renal function is good, and nothing takes glucocorticoid and other influences hypoglycemic medicament history.
Eliminator's standard：Type i diabetes patient；Age is in under-18s or over-65s person, pregnant or women breast-feeding their children； There are the complication such as severe cardiac, liver, kidney, or be associated with other severe primary diseases, mental patient；Loner, it can not sentence Determine the infull person of effect or data.
2nd, test-meal method：100 subjects, two groups are randomly divided into, original takes hypoglycemic medicine kind and dosage is constant, test-meal Tablet prepared by group plus food embodiment 28,3 times a day, 2 tablets once.Control group takes placebo, the same test-meal group of dose, it is desirable to Examination trencherman adheres to diet control for a long time, is fed by different labor intensity and build.Each group is designed using own control, is between two groups Control design between group.
3rd, observation index：Indices in test-meal test start and at the end of each test once, test-meal the 15th day plus survey empty Abdomen blood glucose is once.
Efficiency observation：Detailed medical history-taking, understand patient diet's situation, activity, observe main clinic symptoms：It is more Food, more drink, diuresis, fatigue and weaks etc..Integration is counted before and after test-meal by symptom weight (severe 3 is divided, moderate 2 is divided, mild 1 is divided) Value, and (each 2 points of symptom improvement is effective, and it is effective to improve 1 point) is improved with regard to its cardinal symptom, observe symptom improvement rate.Monitoring Fasting blood-glucose and postprandial 2 hours blood glucose, glucose in urine urine ketone bodies and blood fat.
Experimental group takes tested material, and control group takes identical character without effect placebo.3 tablets each time, 3 times a day, continuously 30 days, subject cut out during experiment
Safety observations：Including blood, urine, feces routine inspection；Biochemical Indexes；Abdominal B-scan ultrasonography, electrocardiogram, x-ray chest are saturating Depending on.
Effect criterion：Cardinal symptom is obviously improved, and it is effective that blood glucose declines >=10% before relatively treating；Cardinal symptom without Be obviously improved, blood glucose drop to reach above-mentioned standard be considered as it is invalid.
4th, experimental result：
General information：100 are observed altogether, test-meal group male 25, women 25, the age is minimum 37 years old, and the oldest 65 It is year, average 54.18 years old, average course of disease 5.94；Control group male 16, women 34, the age is minimum 35 years old, and the oldest 65 It is year, average 54.70 years old, average course of disease 6.01.
Ordinary circumstance compares before two groups of observations：
Ordinary circumstance compares (X ± SD) before table 1 is observed
Table 2 tries trencherman and takes hypoglycemic medicine situation
Group Number of cases Sulfonylureas Biguanides Sulfonylurea+biguanides Do not take
Test-meal group 50 19 11 15 5
Control group 50 18 12 17 3
Table 1, table 2 are visible, indices no significant difference before two groups of test-meals, have comparativity.
Function of reducing blood sugar：On an empty stomach and postprandial blood sugar compares：
Fasting blood-glucose and postprandial 2 hours blood glucose compare (mmol/L, X ± SD) before and after 3 two groups of test-meals of table
Own control * P ＜ 0.05；#P ＜ 0.05 are compareed between 0.01 group of * P ＜
After one month, experimental group fasting blood-glucose averagely declines 1.09mmol/L, and postprandial 2 hours blood glucose averagely declines 1.47mmol/L；Control group fasting blood-glucose and postprandial 2 hours blood glucose decline unobvious.
Fasting blood-glucose, glucose in urine, urine ketone bodies compare：
Fasting blood-glucose and the change of glucose in urine urine ketone bodies are compared (X ± SD) after in before the implementation of table 4
Project Number of cases Before test-meal In test-meal Preceding middle difference Before after examination Front and rear difference
Blood glucose (mmol/L) 50 9.76±2.75 9.23±2.24 -0.53±1.47 8.67±2.24 -1.09±1.66**
(50) (9.17±2.25) (10.03±2.56) (+0.85±1.71) (9.39±2.49) (+0.21±1.55)#
Glucose in urine (integrated value) 18 1.25±1.02 0.94±1.10 0.31±1.33
(16) (1.56±1.06) (1.75±1.11) (+0.19±1.17)
Urine ketone bodies 50 — — 13.83±3.94
(50) (—) (—)
() control group own control * * P ＜ 0.01
Effect of lowering blood sugar compares：
The blood glucose value effect of table 6 counts
Packet Effectively It is invalid Total effective rate (%)
Experimental group Number of cases 32 18 32
Effect rate (%) 64.00 36.00 64.00
Control group Number of cases 12 38 12
Effect rate (%) 24.00 76.00 24.00
Through X2Experiment, two groups of total effective rate significant differences, #P ＜ 0.05.
Symptom improves situation：
The cardinal symptom of table 7 improves situation
Symptom Number of cases It is effective Effectively It is invalid Improvement rate (%)
More foods 11 0 7 4 63.64
(17) (0) (6) (11) (35.29)
More drinks 14 0 7 7 50.00
(17) (1) (6) (10) (41.18)
Diuresis 15 1 7 7 53.33
(15) (0) (6) (9) (40.00)
Lassitude and weak 23 0 12 11 52.17
(22) (0) (9) (13) (40.91)
() control group
In terms of each cardinal symptom improvement, experimental group is superior to control group.
Clinical symptoms integration statistics：
The clinical symptoms of table 8 integration statistics (X ± SD)
Packet Number of cases Before test-meal In test-meal After test-meal
Experimental group 50 7.24±4.90 6.36±4.89*** 5.64±4.89***
Control group 50 7.08±4.84 6.04±4.54*** 5.80±4.50***
Own control * * * P ＜ 0.001
Experimental group and control group play the role of to improve clinical symptoms.
Blood Lipid situation：
Blood Lipid compares (X ± SD) before and after the test-meal of table 9
Experimental group has no significant effect with control group to blood fat items.
Blood safety index observing：
The change of blood safety index is compared (X ± SD) before and after the test-meal of table 10
Before and after two groups of test-meals, blood testing and urine, feces routine indices are in normal range (NR).
Chest X-rays, electrocardiogram, ultrasound diagnosis：Subject is in normal range (NR).
5th, conclusion：This product have it is more obvious reduce on an empty stomach and the effect of postprandial blood sugar, under experimental group fasting blood sugar 1.09 ± 1.66mmol/L drops, and postprandial blood sugar declines 1.47 ± 1.93mmol/L, wherein effective 32, total effective rate 64.00%；Control group fasting blood-glucose and postprandial blood sugar decline unobvious, wherein effective 12, total effective rate 24.00%, two groups Compare that there were significant differences, illustrate that this product has certain effect of lowering blood sugar.The product tries hyperglycaemia trencherman and eats more, drink more, be more The cardinal symptoms such as urine, fatigue and weak, have a better role.After test-meal this product, hemoglobin, red blood cell, leucocyte, serum Total protein, albumin, glutamic-pyruvic transaminase, glutamic-oxalacetic transaminease, inosine, urea, routine urinalysis, just the Index for examination such as conventional items exists Normal range (NR), illustrate that this product has no adverse effects to examination trencherman's health.This product during test-meal do not observe allergy and Other adverse reactions.
It should be understood that after the above-mentioned instruction content of the present invention has been read, those skilled in the art can make to the present invention Various changes or modification, these equivalents equally fall within the application appended claims limited range.

Claims (13)

1. a kind of composition, it is characterised in that include the component of following parts by weight：
5~70 parts of ginseng, 10~80 parts of the Radix Astragali
300~1500 parts of balsam pear, 5~80 parts of the dried rhizome of rehmannia
5~70 parts of Fructus Corni, 5~80 parts of the root of kudzu vine
。
2. composition according to claim 1, it is characterised in that include the component of following parts by weight：
10~50 parts of ginseng, 20~70 parts of the Radix Astragali
500~1200 parts of balsam pear, 10~70 parts of the dried rhizome of rehmannia
10~60 parts of Fructus Corni, 10~70 parts of the root of kudzu vine
。
3. composition according to claim 2, it is characterised in that include the component of following parts by weight：
10~40 parts of ginseng, 30~60 parts of the Radix Astragali
700~1200 parts of balsam pear, 20~60 parts of the dried rhizome of rehmannia
20~50 parts of Fructus Corni, 10~50 parts of the root of kudzu vine
。
4. composition according to claim 3, it is characterised in that include the component of following parts by weight：
15 parts of ginseng, 30 parts of the Radix Astragali, 1000 parts of balsam pear, 30 parts of the dried rhizome of rehmannia, 40 parts of Fructus Corni, 40 parts of the root of kudzu vine.
5. composition according to claim 3, it is characterised in that include the component of following parts by weight：
20 parts of ginseng, 60 parts of the Radix Astragali, 1100 parts of balsam pear, 60 parts of the dried rhizome of rehmannia, 50 parts of Fructus Corni, 50 parts of the root of kudzu vine.
6. composition according to claim 3, it is characterised in that include the component of following parts by weight：
30 parts of ginseng, 45 parts of the Radix Astragali, 900 parts of balsam pear, 45 parts of the dried rhizome of rehmannia, 30 parts of Fructus Corni, 30 parts of the root of kudzu vine.
7. the preparation method of any compositions of claim 1-6, it is characterised in that weigh balsam pear by proportioning and squeeze the juice after filtering Filtrate concentration, filter residue powder, with ginseng, the Radix Astragali, the dried rhizome of rehmannia, Fructus Corni, root of kudzu vine traditional Chinese medicine of the five flavours, are crushed after mixing, or are mixed after crushing Close.
8. the preparation method of any compositions of claim 1-6, it is characterised in that weigh balsam pear by proportioning and squeeze the juice after filtering Filtrate concentration, filter residue powder, ginseng, the Radix Astragali, the dried rhizome of rehmannia, Fructus Corni, root of kudzu vine traditional Chinese medicine of the five flavours are carried out extracting concentration powder, are mixed with Form.
9. the preparation method of composition according to claim 8, it is characterised in that by proportioning weigh balsam pear squeeze the juice filtering after filter Liquid concentration, filter residue powder, ginseng, the Radix Astragali, the dried rhizome of rehmannia concentrate powder processed through water extract-alcohol precipitation, and the root of kudzu vine, Fructus Corni concentrate powder processed through alcohol extracting, mixed Conjunction is prepared.
10. include the oral formulations of any compositions of claim 1-6.
11. oral formulations according to claim 10, it is characterised in that the oral formulations are selected from hard capsule, flexible glue Wafer, tablet, granule, powder, pill, one kind of tea bag.
12. oral formulations according to claim 11, it is characterised in that the preparation is tablet.
13. any compositions of claim 1-6 answering in medicine or health products with auxiliary hyperglycemic effect is prepared With.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1537601A (en) * 2003-04-17 2004-10-20 武汉宇泰科技有限公司 Health-care food for diabetes mellitus patient
CN102204990A (en) * 2011-05-18 2011-10-05 南京中医药大学 Couplet medicine extract for reducing sugar content and preventing diabetic angiopathy and preparation method thereof
CN105878558A (en) * 2014-12-25 2016-08-24 王楠 Folk prescription for treating diabetes mellitus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1537601A (en) * 2003-04-17 2004-10-20 武汉宇泰科技有限公司 Health-care food for diabetes mellitus patient
CN102204990A (en) * 2011-05-18 2011-10-05 南京中医药大学 Couplet medicine extract for reducing sugar content and preventing diabetic angiopathy and preparation method thereof
CN105878558A (en) * 2014-12-25 2016-08-24 王楠 Folk prescription for treating diabetes mellitus

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