CN107817599A - Microscopie unit, microscopic system and image capture method - Google Patents
Microscopie unit, microscopic system and image capture method Download PDFInfo
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- CN107817599A CN107817599A CN201710816053.4A CN201710816053A CN107817599A CN 107817599 A CN107817599 A CN 107817599A CN 201710816053 A CN201710816053 A CN 201710816053A CN 107817599 A CN107817599 A CN 107817599A
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- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000003287 optical effect Effects 0.000 claims description 68
- 239000000758 substrate Substances 0.000 claims description 29
- 239000000049 pigment Substances 0.000 claims description 20
- 230000004913 activation Effects 0.000 claims description 13
- 238000005286 illumination Methods 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 239000000523 sample Substances 0.000 description 206
- 238000012545 processing Methods 0.000 description 20
- 230000009471 action Effects 0.000 description 14
- 238000010586 diagram Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/368—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements details of associated display arrangements, e.g. mounting of LCD monitor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/28—Base structure with cooling device
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/361—Optical details, e.g. image relay to the camera or image sensor
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/60—Control of cameras or camera modules
- H04N23/63—Control of cameras or camera modules by using electronic viewfinders
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/26—Stages; Adjusting means therefor
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Signal Processing (AREA)
- Microscoopes, Condenser (AREA)
Abstract
The present invention discloses microscopie unit, microscopic system and image capture method.Increase the viewing area of display part, and reduce the setting area of device.The microscopie unit (100) possesses：Sample setting unit (11), for setting sample；Image pickup part (10d), the sample for being arranged at sample setting unit (11) is imaged；Frame (10), sample setting unit (11) is set, and image pickup part (10d) configuration is internally；Display part (21), show the image imaged by image pickup part (10d)；And move portion (20), it is integrally provided, can be relatively moved relative to sample setting unit (11) with display part (21).
Description
Technical field
The present invention relates to microscopie unit, microscopic system and image capture method.
Background technology
In Japanese Unexamined Patent Publication 2015-084060 publications, as shown in Figure 24 and Figure 25, a kind of microscope dress is disclosed
800 are put, the microscopie unit 800 possesses：Mounting table support 811, mounting table 810 is provided with, the mounting table 810 is configured with measurement
Object；Object lens 820, configured in a manner of opposed with mounting table support 811；Video camera 840, according to the light-projecting portion 830 of outside
Light, measurement object thing is imaged；And upper table cover 850 and preceding surface cover 860, covering mounting table support 811, shape
As darkroom state.The measurement object thing for being configured to be imaged by video camera 840 in the microscopie unit 800 be shown in it is micro-
The display part 870 for the outside that lens device 800 is provided independently from.
The content of the invention
In the microscopie unit 800 of above-mentioned Japanese Unexamined Patent Publication 2015-084060 publications, the measurement object thing that is imaged
The display part 870 for the outside being provided independently from microscopie unit 800 is shown in, so needing to set display part 870 in addition.Such as
Fruit wants the viewing area of increase display part 870, then needs further exist for the setting area of device.Therefore, set except being necessary to ensure that
Beyond the space for putting microscopie unit 800, it is also necessary to ensure to set the space of display part 870, so setting area be present becomes big
The problem of point.
It is an object of the present invention to increase the viewing area of display part, and reduce the setting area of device.
The microscopie unit 100 of the 1st situation of the present invention possesses：Sample setting unit 11, for setting sample；Image pickup part
10d, the sample for being arranged at sample setting unit 11 is imaged；Frame 10, sample setting unit 11, and image pickup part is set
10d is configured internally；Display part 21, show the image imaged by image pickup part 10d；And move portion 20, with the one of display part 21
Ground is set, and can be relatively moved relative to sample setting unit 11.
In the microscopie unit 100 of the 1st situation of the present invention, as described above, display part 21 is integrally provided to show
Micro-mirror device 100, without being also separately provided display part 21 in addition to microscopie unit 100, so device can be reduced
Setting area.In addition, by the way that display part 21 is integrally provided to be relatively moved relative to sample setting unit 11
Move portion 20, the moving range of move portion 20 can be applied flexibly in the viewing area of display part 21, compared to move portion 20
The situation of display part is provided separately, the viewing area of display part 21 can be increased to greatest extent.Imaged by image pickup part 10d
Image in, such as including scotopia field picture, fluoroscopic image, bright field image.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that move portion 20 is configured to by relative to framework
Portion 10 relatively slides, so as to be relatively moved relative to sample setting unit 11.If so formed, can easily make
Move portion 20 is relatively moved relative to sample setting unit 11.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that move portion 20 is configured to be moved to covering
1st position of sample setting unit 11 and the 2nd position of unlimited sample setting unit 11.If so form, by making movement
Portion 20 is moved to the 2nd position, easily can carry out operation to sample setting unit 11.By making move portion 20 be moved to the 1st
Put, sample setting unit 11 can be covered and shading easily is carried out to exterior light.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that be also equipped with cap, the cap with by move portion 20
Movement to sample setting unit 11 covers sample setting unit 11 in linkage.If so form, only by making the phase of move portion 20
Being moved for sample setting unit 11 just can simply cover sample setting unit 11.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that move portion 20 includes：Horizontal plane 20a, in level
Side upwardly extends, and covers from above sample setting unit 11；And cross facet 20b, with horizontal plane 20a link, with horizontal plane 20a
The side of intersection upwardly extends, and side side covering sample setting unit 11 from horizontal direction, display part 21 is configured at cross facet 20b.
If so formed, the movement of move portion 20 can be made to open wide a side of the top of sample setting unit 11 and horizontal direction
Side, so sample setting unit 11 can be easily accessed.Thereby, it is possible to more easily carry out the operation to sample setting unit 11.
That is, in the case where moving move portion 20, display part 21 can be made also to be moved with together with move portion 20, in order to avoid visiting
Turn into obstacle when asking the sample setting unit 11 for being arranged at frame 10.Thereby, it is possible to easily enter to be about to sample to be configured at sample
The operation of the grade of setting unit 11.
In which case it is preferable that sample setting unit 11 is arranged in the low positions of the horizontal plane 20a than move portion 20
Frame 10.If so formed, the top of sample setting unit 11 can be opened wide, user can be from the upper of sample setting unit 11
Side easily carries out sample setting action to sample setting unit 11 etc..
In the structure that above-mentioned move portion 20 includes horizontal plane 20a and cross facet 20b, it is preferred that cross facet 20b is formed
Overall to cover the face of a side side of the horizontal direction of frame 10, display part 21 is configured at the substantially overall of cross facet 20b.Such as
Fruit is so formed, then can increase display part 21, so display content can be observed easily.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that be also equipped with substrate 18, the substrate 18 is configured in frame
The inside in body portion 10, image pickup part 10d is configured with, image pickup part 10d includes object lens 12, and the object lens 12 are configured to optical axis relative to sample
The sample setting face of the setting sample of setting unit 11 is substantially vertical, and substrate 18 is configured to almost parallel with the optical axis of object lens 12.Such as
Fruit is so formed, then can efficiently configure image pickup part 10d in the inner space of frame 10.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that display part 21 relative to vertical to have
The mode of predetermined gradient is configured at move portion 20, and move portion 20 is configured to the shape for having predetermined gradient with display part 21
State is relatively moved relative to sample setting unit 11.If so formed, display part 21 can be made to incline with predetermined
The state of gradient is relatively moved, so which position can easily observe display part 21 in.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that sample setting unit 11 is configured at approximate horizontal
The upper surface of frame 10.If so formed, can easily carry out setting to sample from the top of sample setting unit 11
The sample setting action in portion 11 etc..
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that sample setting unit 11 move portion 20 relative to
Configuration is near the end of frame 10 on the direction that sample setting unit 11 is relatively moved.If so form, such as
In the case where carrying out the on-off action of sample setting unit 11 by moving move portion 20, by make move portion 20 movement with
Length Quantity corresponding to the width of sample setting unit 11, sample setting unit 11 can be opened and closed.Therefore, it is possible to suppress in movement
Microscopie unit 100 becomes to maximize when portion 20 is relatively moved.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that move portion 20 is configured to relative to sample
Setting unit 11 is relatively moved in the horizontal direction.If so form, with making move portion 20 relative to sample setting unit
11 situations about moving in vertical direction are compared, and can suppress microscopie unit 100 becomes to maximize in the vertical direction.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that possess fan 193, the fan 193 is configured in frame
The inside in body portion 10, for being cooled down to the inside of frame 10, fan 193 is configured at and configured in the inside of frame 10
The region that the region for having image pickup part 10d separates, the stopping action during the shooting of the sample carried out by image pickup part 10d.If
So form, then can prevent from being delivered to image pickup part 10d, sample setting unit 11 in the vibration caused by fan 193 during shooting
Deng, thus can precision sample is imaged well.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that image pickup part 10d includes light source 13, object lens 12, taken the photograph
Element 14, the 1st optical element 15 and the 2nd optical element 16b, 16c, 16f and 16g, above-mentioned 1st optical element 15 make from
The light that light source 13 irradiates reflects to the optical axis direction of object lens 12, transmits the light from sample, above-mentioned 2nd optical element 16b, 16c,
16f and 16g makes the light from sample be reflected towards photographing element 14., can be by the 1st optical element 15 if so formed
Light from light source 13 is directed to sample via object lens 12, and can be by the light from sample via the 2nd optical element
16b, 16c, 16f and 16g are directed to photographing element 14.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that image pickup part 10d includes：1st light source 131a, use
Sample is mapped in the illumination for the wavelength that a part for multiple pigments for making to be combined with sample is turned into state of activation；And the
2 light source 131b, for the illumination for the wavelength for turning into unactivated state for becoming multiple pigments of state of activation to be mapped into examination
Material.If so form, can make with sample combine multiple pigments a part as state of activation and light, so energy
It is enough that sample is imaged by image pickup part 10d according to luminous.
In the structure that above-mentioned image pickup part 10d includes the 1st light source 131a and the 2nd light source 131b, it is preferred that image pickup part
10d is configured to photograph to the light sent from the pigment of a part in multiple pigments, as state of activation.If so
Form, then image can be imaged according to the luminous of the pigment of the part as state of activation.
In the structure that above-mentioned image pickup part 10d includes the 1st light source 131a and the 2nd light source 131b, it is preferred that image pickup part
10d is configured to repeatedly image sample, and display part 21 is configured to display to be carried out to multiple images imaged by image pickup part 10d
The image being synthesized into.If so formed, by synthesizing multiple images, super-resolution image can be imaged.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that frame 10 is with length in one direction
Inner space, image pickup part 10d include object lens 12, light source 13 and photographing element 14, and object lens 12 are configured to optical axis and frame 10
Length direction it is substantially vertical, light source 13 and photographing element 14 configure on the length direction of frame 10 relative to object lens 12
In the same side.If so formed, the size that can suppress the above-below direction of microscopie unit 100 becomes big.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that be also equipped with：Drive division 10a, make the phase of move portion 20
Relatively moved for sample setting unit 11；And controller 192, drive division 10a is controlled, controller 192 is in frame 10
Inside be configured at and be configured with the region that image pickup part 10d region separates, be configured to the operation according to user, utilize drive division
10a relatively moves move portion 20.If so formed, can with image pickup part 10d isolator Configuration Control Unit 192, so
The heat transfer of controller 192 can be suppressed to image pickup part 10d.The component that the region by Configuration Control Unit 192 separates can be utilized
To improve image pickup part 10d light-proofness.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that be also equipped with controller 192, the controller 192 is controlled
The irradiation by the image pickup part 10d light carried out is made, controller 192 is configured at and be configured with image pickup part 10d in the inside of frame 10
The region that separates of region.If so formed, can with image pickup part 10d isolator Configuration Control Unit 192, so can press down
The heat transfer of controller 192 processed is to image pickup part 10d.The component that the region by Configuration Control Unit 192 separates can be utilized to improve
Image pickup part 10d light-proofness.
In the structure that above-mentioned move portion can be moved to the 1st position and the 2nd position, it is preferred that sample setting unit
11 are arranged at frame in a manner of the part in addition to the direction side of horizontal direction and upside is surrounded by wall with concavity
The upper surface in body portion 10, it is configured in the case where move portion 20 is located at the 2nd position, open wide upside and horizontal direction one
Direction side, display part 21 configure the direction side of the horizontal direction in move portion 20.If so form, in move portion
In the case that 20 are located at the 1st position, it can suppress to come from side using the wall for surrounding sample setting unit 11 together with move portion 20
The intrusion of the light of side.In the case where move portion 20 is located at the 2nd position, upside and the direction side of horizontal direction are opened wide,
So it can more easily access sample setting unit 11.
In the microscopie unit 100 of above-mentioned 1st situation, it is preferred that image pickup part 10d is included upward to configuration
Immersion objective.If so formed, when moving move portion 20, open wide top and be configured with the side of display part 21,
So immersion objective can be easily accessed.Thereby, it is possible to easily carry out the work to drip etc. of the liquid for immersion objective
Industry.
The microscopic system 300 of the 2nd situation of the present invention possesses microscopie unit 100 and control microscopie unit 100
Control unit 200, microscopie unit 100 possesses：Sample setting unit 11, for setting sample；Image pickup part 10d, to being arranged at examination
The sample of material setting unit 11 is imaged；Frame 10, sample setting unit 11 is provided with, and image pickup part 10d configurations are internally；
Display part 21, the image imaged by image pickup part 10d is shown；And move portion 20, it is integrally provided with display part 21, energy
It is enough to be relatively moved relative to sample setting unit 11.
In the microscopic system 300 of the 2nd situation of the present invention, play same with the microscopie unit of above-mentioned 1st situation
Action effect.
The image capture method of the 3rd situation of the present invention is to utilize the microscopie unit 100 for being provided integrally with display part 21
Image capture method, above-mentioned image capture method include：Display part 21 is set to be carried out relatively relative to the sample setting unit 11 of microscopie unit 100
Move to open wide the process of sample setting unit 11；Make display part 21 be relatively moved relative to sample setting unit 11 to set to cover
It is equipped with the process of the sample setting unit 11 of sample；And by microscopie unit 100 in the state of sample setting unit 11 is capped
The process imaged to the sample for being arranged at sample setting unit 11.
In the image capture method of the 3rd situation of the present invention, the effect same with the microscopie unit of above-mentioned 1st situation is played
Effect.
The viewing area of display part can be increased, and reduce the setting area of device.
Brief description of the drawings
Fig. 1 is the stereogram for an example for showing microscopie unit.
Fig. 2 is the stereogram for an example for showing microscopic system.
Fig. 3 is the schematical stereogram for illustrating the structure of the inside of microscopie unit example.
Fig. 4 is the schematical stereogram for illustrating configuration in an example of the substrate of the inside of microscopie unit.
Fig. 5 is the side view for an example for showing microscopie unit.
Fig. 6 is the stereogram from the back side for an example for showing microscopie unit.
Fig. 7 be the frame that shows to make microscopie unit and movable part from state stereogram.
Fig. 8 is the figure for illustrating the connection of the substrate of microscopie unit.
Fig. 9 is the figure being connected for illustrating the frame of microscopie unit with move portion.
Figure 10 is for illustrating that be equipped with configuration shows in example of the substrate of the fan of the inside of microscopie unit
The figure of meaning property.
Figure 11 is the rearview for an example for showing microscopie unit.
Figure 12 is the block diagram of an example of the control structure for showing microscopic system.
Figure 13 is the schematical stereogram of the structure for the 1st variation for showing microscopie unit.
Figure 14 is the schematical stereogram of the structure for the 2nd variation for showing microscopie unit.
Figure 15 is the schematical stereogram of the structure for the 3rd variation for showing microscopie unit.
Figure 16 is the block diagram of the control structure for the 3rd variation for showing microscopie unit.
Figure 17 is the schematical stereogram of the structure for the 4th variation for showing microscopie unit.
Figure 18 is the block diagram of the control structure for the 4th variation for showing microscopie unit.
Figure 19 is the block diagram of an example of the structure for the light source for showing microscopie unit.
Figure 20 is the figure of an example of the display picture for the display part for showing microscopie unit.
Figure 21 is the flow chart for an example for showing image pickup processing.
Figure 22 is the flow chart for an example for showing super-resolution image shooting processing.
Figure 23 is to show that super-resolution image makes the flow chart of an example of processing.
Figure 24 is the stereogram for showing conventional microscopie unit.
Figure 25 is the block diagram for showing conventional microscopie unit.
Symbol description
10、410、510、610、710：Frame；10a：Drive division；10d：Image pickup part；11、411、511、611、711：Examination
Expect setting unit；12：Object lens；13：Light source；14：Photographing element；15：1st optical element；16b、16c、16f、16g：2nd optics member
Part；18：Substrate；20、420、520、620、720：Move portion；20a：Horizontal plane；20b：Cross facet；21、421、521、621、
721：Display part；21a：Display surface；100、400、500、600、700：Microscopie unit；131a：1st light source；131b：2nd light
Source；192：Controller；193：Fan；200：Control unit；300：Microscopic system.
Embodiment
Hereinafter, embodiment is illustrated with reference to the accompanying drawings.
(overall structure of microscopie unit)
Reference picture 1, illustrate the summary of the microscopie unit 100 of present embodiment.
Microscopie unit 100 is the device for amplifying and showing the sample for being placed in sample setting unit 11.Sample is
From the biological sample of subject (testee) extraction, e.g. cell etc..
As shown in figure 1, microscopie unit 100 possesses frame 10 and move portion 20.Microscopie unit 100 possesses image pickup part
10d and sample setting unit 11.Image pickup part 10d possesses object lens 12, light source 13 and photographing element 14.Sample setting unit 11 is arranged at
The upper surface (face of Z1 directions side) of frame 10.Object lens 12, light source 13 and photographing element 14 are arranged on the interior of frame 10
Portion.Microscopie unit 100 possesses display part 21.Display part 21 is arranged at the preceding surface (face of Y1 directions side) of move portion 20.It is aobvious
Show the front-surface side of the display surface 21a configurations in move portion 20 in portion 21.Microscopie unit 100 possesses drive division 10a, the drive division
10a makes move portion 20 be relatively moved relative to frame 10.
Hereinafter, by two sides orthogonal (that is, in horizontal face) in the face parallel with the setting face of microscopie unit 100
To being set to X-direction, Y-direction.As shown in figure 1, microscopie unit 100 has when overlooking respectively along the X direction and Y side
To rectangular shape outer shape.X-direction is set to the left and right directions of microscopie unit 100, Y-direction is set to micro-
The fore-and-aft direction of lens device 100.Y1 directions are the preceding surface direction of apparatus main body, and Y2 directions are the back side direction of apparatus main body.
The above-below direction orthogonal with the face of level is set to Z-direction.Z1 directions are upper direction, and Z2 directions are lower direction.
Move portion 20 can be relatively moved to covering sample setting unit 11 relative to frame 10 together with display part 21
Shading position (reference picture 1 (A)) and the open position (reference picture 1 (B)) of unlimited sample setting unit 11.Specifically, move portion
20 relative to frame 10 on the setting face with frame 10 direction that be substantially parallel by relatively entering line slip, so as to phase
To being moved to shading position and open position.Thereby, it is possible to make move portion 20 relative to frame 10 not in above-below direction (Z
Direction) but relatively moved in transverse direction (X-direction), so the influence of gravity can be suppressed, easily make the phase of move portion 20
Shading position or open position are arrived for the relative movement of frame 10.Shading position and open position can be configured at flat
Capable position, so in open position also the aobvious of move portion 20 can be arranged in the height and position observation same with shading position
Show portion 21.Thereby, it is possible to improve the visibility of display part 21.Arrive and open relative to the relative movement of frame 10 in move portion 20
In the state of open position, sample is arranged on sample setting unit 11.In move portion 20 relative to the relative movement of frame 10 to screening
In the state of optical position, the sample of sample setting unit 11 is imaged.In addition, shading position is claims " the 1st
Put " example, open position is an example of claims " the 2nd position ".
As shown in figure 1, move portion 20 and the setting face of frame 10 are almost parallel, and in the length direction (X of frame 10
Direction) on relatively slid relative to frame 10.Specifically, the state not moved relative to setting face in frame 10
Under, move portion 20 moves relative to frame 10 and setting face.Move portion 20 can be configured in the display with display part 21
Face 21a direction that be substantially parallel to be relatively moved relative to frame 10.In other words, move portion 20 can with frame
Relative to frame in 10 side (side in the X1 directions and X2 directions) generally perpendicular direction (X-direction) with preceding surface crosswise
Body portion 10 is relatively moved.Thus, with making move portion 20 in the direction vertical with the display surface 21a of display part 21 i.e. frame
Situation about being relatively moved on 10 fore-and-aft direction (Y-direction) is different, can be easily to be moved to move portion 20 unlimited
In the case of position sample setting unit 11 is accessed from front.
By the control from outside, move portion 20 is set to be relatively moved relative to frame 10 using drive division 10a.
For example, according to the operation of user or program, drive division 10a is driven, so as to move portion 20 relative movement to shading position with
And open position.Thereby, it is possible to make move portion 20 easily relatively move to arrive shading position and open position.Drive division 10a examples
Such as include motor and belt wheel mechanism.
As shown in figure 1, sample is set in sample setting unit 11.Sample setting unit 11 is configured at the setting face with frame 10
The almost parallel upper surface of frame 10 (face in Z1 directions).Thus, feelings of the relative movement of move portion 20 to open position are made
Under condition, the top of sample setting unit 11 can be opened wide, so sample setting unit 11 can be easily accessed.
Sample setting unit 11 is so that what the part in addition to the direction side of horizontal direction and upside was surrounded by wall
Mode is arranged at the upper surface of frame 10 with concavity.For example, sample setting unit 11 with frame 10 except front-surface side with
And the mode surrounded by wall of the part beyond upside is arranged at the upper surface of frame 10 with concavity.Specifically, sample is set
The wall portion 112 that portion 11 is included in the wall portion 111 of Y2 directions setting and configured in X-direction in a manner of opposed.Sample setting unit
11 X1 directions side, X2 directions side and Y2 directions side is surrounded by wall portion 111 and a pair of wall portions 112.Thus, in move portion 20
, can be with the part in addition to preceding surface together with move portion 20 using sample setting unit 11 in the case of shading position
Wall suppress the intrusion of the light from side.Sample setting unit 11 is opened wide in the case where move portion 20 is located at open position
Upside and the direction side of horizontal direction.For example, sample setting unit 11 is in the case where move portion 20 is located at open position,
Open wide top (Z1 directions) and front (Y1 directions).Thus, in the case where move portion 20 is located at open position, top is opened wide
And front, so sample setting unit 11 can be accessed more easily.
Sample setting unit 11 is configured in frame on the direction that move portion 20 is relatively moved relative to frame 10
Near 10 end.Sample setting unit 11 is configured at the upper surface near the end in the X-direction of frame 10.As shown in figure 1,
Sample setting unit 11 is configured near the end of the X1 directions side of frame 10.Thus, by making move portion 20 relative to framework
Portion 10 relatively moves Length Quantity corresponding with the width of sample setting unit 11, move portion 20 can be made to be moved to open position, institute
Become the phenomenon of maximization so that the microscopie unit 100 when move portion 20 is moved to open position can be suppressed.
Sample setting unit 11 includes mounting table 11a.Mounting table 11a can in the horizontal direction (X-direction and Y-direction) and
Moved on above-below direction (Z-direction).Mounting table 11a can move independently of each other in X-direction, Y-direction and Z-direction.By
This, can be such that sample is relatively moved relative to object lens 12, so can amplify the desired position of sample and observe.
As shown in figure 1, object lens 12 are configured to the mounting table 11a close to sample setting unit 11.Object lens 12 are configured to approach examination
Expect the mounting table 11a of setting unit 11 lower section (Z2 directions).Object lens 12 are arranged on above-below direction (Z-direction) set with sample
Portion 11 is opposed.It is substantially vertical relative to the sample setting face of the setting sample of sample setting unit 11 that object lens 12 are configured to optical axis.Thing
Mirror 12 is upward to configuration.Object lens 12 can relatively move relative to sample setting unit 11 on above-below direction (Z-direction).Thing
Mirror 12 is configured to have length direction in the vertical direction.That is, object lens 12 are configured to substantially in vertical have
Optical axis.Object lens 12 include multiple lens.Object lens 12 can amplify sample according to predetermined multiplying power.Object lens 12 include immersion lens.
That is, the liquid such as the oil such as silicone oil, water are dripped into object lens 12 and used.In addition, object lens 12 may not be immersion lens.
The dropping liquid of object lens 12 can not be used.
As shown in figure 1, light source 13 can be to sample irradiation light.Light source 13 is via object lens 12 to sample irradiation light.Light source 13
From with the identical side of photographing element 14 to sample irradiation light.Light source 13 can export the light of predetermined wavelength.Light source 13 can
Export the light of different multiple wavelength.That is, light source 13 can export different types of light.Light source 13 includes luminous member
Part.Light-emitting component is such as including LED element or laser diode.
As shown in figure 1, photographing element 14 can image according to the light irradiated from light source 13 to sample.Specifically,
Photographing element 14 can be according to the light sent due to the light irradiated from light source 13 from sample, the still image or dynamic to sample
State image is imaged.Photographing element 14 includes photographing element.Photographing element is for example including CCD elements, cmos element.Shooting member
Part 14 can carry out high sensitivity shooting.That is, photographing element 14 can be imaged according to faint light.Photographing element
14 can also be based on being arranged on the light source (not shown) with the opposite side of object lens 12 (Z1 directions side) relative to sample setting unit 11
Light, sample is imaged.That is, photographing element 14 can also transmit sample based on the rear side irradiation from sample
Light, sample is imaged.
As shown in figure 1, display part 21 can show the image imaged by photographing element 14.Display part 21 and move portion 20 1
Set body.Display part 21 can show the picture for operation microscope device 100.Display part 21 can be shown based on to examination
The picture of program when material is imaged.Display part 21 can be shown to the picture for the state for representing microscopie unit 100.
Display part 21 can show the picture of the signal based on the control unit from outside.Display part 21 configures the water in move portion 20
Square to direction side.For example, display part 21 configures the front side (Y1 directions side) in move portion 20.
As shown in figure 1, move portion 20 is included horizontal plane 20a, cross facet 20b and matched somebody with somebody in a manner of opposed in the X direction
A pair of the side 20c put.Horizontal plane 20a is configured to direction that be substantially parallel in the setting face with frame 10 and prolonged on (XY directions)
Stretch, cover from above the sample setting unit 11 of frame 10.Cross facet 20b be configured to horizontal plane 20a link, with horizontal plane
The side that 20a intersects upwardly extends, from the sample setting unit 11 of the side side covering frame 10 almost parallel with setting face.Specifically
For, cross facet 20b is configured to the sample setting unit 11 from front covering frame body portion 10.Thus, the relative shifting of move portion 20 is made
In the case of moving open position, the top and front of sample setting unit 11 can be opened wide, so examination can be easily accessed
Expect setting unit 11.As a result, it can more easily carry out the operation to sample setting unit 11.By the way that display part 21 is configured at into friendship
Fork face 20b, display part 21 can be configured at preceding surface, so the visibility of display part 21 can be improved.Side 20c connects
Tie in the lower section at the both ends of horizontal plane 20a X-direction.Side 20c is formed as extending in vertical.Side 20c is configured to
From the sample setting unit 11 of X-direction side covering frame 10.Move portion 20 is shaped generally as by horizontal plane 20a and cross facet 20b
Reverse L word shape.Display part 21 is configured with cross facet 20b.
As shown in figure 1, it is configured in the case where move portion 20 is located at shading position, big with the setting face of frame 10
Cause parallel and on the length direction of frame 10, framework is covered by being configured at the cross facet 20b display part 21 of move portion 20
Portion 10 it is substantially overall.Display part 21 is configured at the substantially overall of cross facet 20b.Cross facet 20b is configured in move portion 20
In the case of shading position, cover frame 10 preceding surface it is substantially overall.Transverse direction (X-direction) of the display part 21 in picture
On configured throughout cross facet 20b substantially overall of move portion 20.Display part 21 is in the longitudinal direction of picture (side along the Z direction
To) on configure throughout cross facet 20b substantially overall of move portion 20.Thereby, it is possible to display part 21 is configured at into covering frame
The substantially overall scope of the length direction (X-direction) on the preceding surface in body portion 10, so display part 21 can be increased.As a result,
Display content can easily be observed.
Display part 21 is configured to have predetermined inclination relative to the direction (Z-direction) vertical with the setting face of frame 10
Degree.In other words, the cross facet 20b of move portion 20 is configured to relative to the direction (Z-direction) vertical with setting face with predetermined
Gradient.For example, display part 21 is matched somebody with somebody with the state that about 1 degree~about 30 degree or so are tilted relative to the direction vertical with setting face
Put.Display part 21 is configured to lower end (Z2 directions end), and relative to upper end (Z1 directions end), (Y1 directions) is prominent forwards.Thus, phase
Than situation about being configured in display part 21 along the direction vertical with setting face, display part 21 can be easily observed.It is configured with display
The part of the move portion 20 in portion 21 has the gradient roughly the same with predetermined gradient.
The preceding surface (face in Y1 directions) of frame 10 has the predetermined gradient with cross facet 20b is roughly the same to incline
Gradient.The mask of the frame 10 opposed with the part of the move portion 20 with the gradient roughly the same with predetermined gradient
There is the gradient roughly the same with predetermined gradient.The preceding surface of frame 10 and display part 21 are almost parallel.Thereby, it is possible to
Make the gradient on the preceding surface of frame 10 roughly the same with the gradient of display part 21, so can make to be configured with display part 21
Move portion 20 thickness constant.As a result, the thickness that can suppress the part of the configuration display part 21 of move portion 20 becomes
Greatly, so can suppress move portion 20 becomes to maximize.Thereby, it is possible to suppress the drive division 10a for moving move portion 20
Become big.
Sample setting unit 11 is carried out by so setting to relatively move to for exterior light relative to frame 10
The move portion 20 of the open position of the shading position of shading and unlimited sample setting unit 11, sample can be set in shooting
Portion 11 carries out shading.Thereby, it is possible to set microscopie unit 100 not in darkroom, and as inspection chamber, pathology classroom
Bright place sets microscopie unit 100 to use.By the way that display part 21 is integrally provided into move portion 20, without
Display part is also separately set in addition to microscopie unit 100 is set, so setting area can be reduced.By making integratedly to set
Shading position and open position are arrived in the relative movement of move portion 20 for being equipped with display part 21, so that unlimited being moved to move portion 20
In the case of position, display part 21 can be made also to be moved with together with move portion 20, in order to avoid turn into when accessing sample setting unit 11
Obstacle.The operation for being configured at the grade of sample setting unit 11 thereby, it is possible to easily enter to be about to sample.It is spacious being moved to move portion 20
In the case of open position, display part 21 will not turn into obstacle when accessing sample setting unit 11, so can increase to greatest extent
Big display part 21.Thereby, it is possible to the sample for confirming to amplify in detail and showing.
(configuration example of microscopic system)
Next, reference picture 2, illustrate the specific configuration example of microscopic system 300.
As shown in Fig. 2 microscopic system 300 possesses microscopie unit 100 and control unit 200.Microscopie unit 100 and
Control unit 200 is connected in a manner of it can mutually send and receive signal.For example, microscopie unit 100 and the energy of control unit 200
Enough connected by wired or wireless inter-communication.
Control unit 200 is configured to control microscopie unit 100.Control unit 200 is for example made up of computer, including CPU (in
Entreat arithmetic processing apparatus), memory etc..The shooting processing of sample of the control unit 200 to being carried out by microscopie unit 100 is controlled
System.Movement of the control unit 200 to the shading position and open position of the move portion 20 of microscopie unit 100 is controlled.Control
Portion 200 is according to programme-control microscopie unit 100.Control unit 200 can enter to be about to be put by the sample that microscopie unit 100 images
The image procossing of image after big.Image after processing can be output to microscopie unit 100 by control unit 200, make microscope
The display part 21 of device 100 is shown.Control unit 200 can make the image based on program be shown in the display of microscopie unit 100
Portion 21.
(configuration example of optical system)
Next, reference picture 3 and Fig. 4, illustrate the configuration example of the optical system of microscopie unit 100.
As shown in figure 3, microscopie unit 100 possesses object lens 12, light source 13, photographing element as the structure of optical system
14th, the 1st optical element 15, filter 16a, the 2nd optical element 16b, 16c, 16f and 16g, lens 16d, 16e and 16h,
Reflecting part 17a, 17b and 17d and lens 17c.Object lens 12, light source 13, photographing element 14, the 1st optical element 15, filter
16a, the 2nd optical element 16b, 16c, 16f and 16g, lens 16d, 16e and 16h, reflecting part 17a, 17b and 17d and
Lens 17c is configured in the inside of frame 10.
1st optical element 15 is configured to make to reflect from the light that light source 13 irradiates to the optical axis direction of object lens 12, and transmission comes from
The light of sample.1st optical element 15 is for example including dichronic mirror.That is, the 1st optical element 1 is configured to make to shine from light source 13
The light reflection for the wavelength penetrated, makes the wavelength transmission from light caused by sample.
Filter 16a is configured to the light transmission for making predetermined wavelength, and the light of wavelength in addition is covered, or
The light of predetermined wavelength is covered, makes the light transmission of wavelength in addition.That is, transmitted using filter 16a
The light of desired wavelength, reach photographing element 14.
2nd optical element 16b, 16c, 16f and 16g is configured to make the light from sample reflect towards photographing element 14.
2nd optical element 16b, 16c, 16f and 16g includes reflecting part.2nd optical element 16b, 16c, 16f and 16g for example including
Speculum.
Reflecting part 17a, 17b and 17d are configured to make the light from light source 13 reflect towards object lens 12.Reflecting part 17a,
17b and 17d is for example including speculum.
The light projected from light source 13 is reflected by reflecting part 17a and incides reflecting part 17b.Incide reflecting part 17b light
Reflecting part 17d is incided via lens 17c by reflection.The light for inciding reflecting part 17d is reflected and incides the 1st optics member
Part 15.The light for inciding the 1st optical element 15 reaches sample setting unit 11 by reflection and via object lens 12, is irradiated to sample.
1st optical element 15 is incided via object lens 12 from the light that sample is sent according to the light of light source 13.Incide the 1st light
The light for learning element 15 is transmitted and incides the 2nd optical element 16b via filter 16a.Incide the 2nd optical element 16b's
Light is reflected and incides the 2nd optical element 16c.The 2nd optical element 16c light is incided by reflection and via lens 16d with
And 16e incides the 2nd optical element 16f.The light for inciding the 2nd optical element 16f is reflected and incides the 2nd optical element
16g.The 2nd optical element 16g light is incided by reflection and reaches photographing element 14 via lens 16h.The basis of photographing element 14
The light of arrival images to the enlarged drawing of sample.
Light source 13 is configured at so that the mode that the light from light source 13 advances along substantially vertical (Z-direction) at least changes
1 direction and incide the position of object lens 12.That is, light source 13 is configured at the position of the light shaft offset relative to object lens 12
Put.Thus, when in the case where being substantially configured with object lens 12 in vertical, the extended line without the optical axis direction in object lens 12
Upper setting light source 13, so the size that can suppress the above-below direction of microscopie unit 100 becomes big.
Photographing element 14 is configured at the light from sample and direction that be substantially parallel at least change 1 time from the optical axis with object lens 12
Direction and the position for inciding photographing element 14.That is, photographing element 14 is configured at the light shaft offset relative to object lens 12
Position.Thus, without setting photographing element 14 on the extended line of the optical axis direction of the light from sample, so can suppress
The size of the above-below direction of microscopie unit 100 becomes big.
As shown in figure 3, microscopie unit 100 possesses shooting cover 14a, the light that the shooting cover 14a images to photographing element 14
The exterior light in the region in incident direction carries out shading.Shooting cover 14a is configured to surround the incident side of light of photographing element 14
Optical axis.That is, the light for being configured to incide photographing element 14 only turn into from the light that sample is sent via optical system to
The light reached.Shooting cover 14a is formed by the cloth of light-proofness, sheet material etc..For example, shooting cover 14a is formed by black cloth.Thereby, it is possible to profit
Dual shading is carried out to exterior light with shooting cover 14a and frame 10, thus can precision carry out better it is first by shooting
The shooting that part 14 is carried out.
As shown in figure 4, microscopie unit 100 possesses substrate 18, the substrate 18 is configured with object lens 12, light source 13 and shooting
Element 14, the object lens 12 are configured in the inside of frame 10, and it is substantially vertical relative to sample setting unit 11 to be configured to optical axis.Substrate
18 be configured to it is substantially vertical (reference picture 5) relative to the setting face of frame 10.Substrate 18 is configured to big with the optical axis of object lens 12
Cause parallel.Specifically, substrate 18 is configured to extend along XZ planes.Thereby, it is possible to object lens 12, light source 13 and shooting is first
Part 14 is configured at common substrate 18, so the position relationship that can suppress the component of optical system deviates.
1st optical element 15 and the 2nd optical element 16b, 16c, 16f and 16g configurations are on substrate 18.Thereby, it is possible to
Light source 13, the 1st optical element 15 and the 2nd optical element 16b, 16c, 16f and 16g are configured at common substrate 18, institute
Closed so that light source 13, the 1st optical element 15 and the 2nd optical element 16b, 16c, 16f and 16g relative position can be suppressed
System deviates.
(example of frame and the connecting structure of move portion)
Next, 6~Fig. 9 of reference picture, illustrates the frame 10 of microscopie unit 100 and the connecting structure of move portion 20
Example.
As shown in Fig. 6 and Fig. 7, frame 10 includes the holding section 10b that (Z1 directions) is prominent upward.Move portion 20 is wrapped
Include the recess 22 engaged with the holding section 10b of frame 10.Recess 22 is formed as being recessed in the vertical direction.Recess 22 is formed as
Extend in the X direction.As shown in fig. 6, the recess 22 of move portion 20 engages with the holding section 10b of frame 10.Thus, move portion
20 can be movably attached in the X direction relative to frame 10.
As shown in figure 8, configuration the inside of frame 10 substrate 18 include connection terminal 181, flexible cable 182 and
Connection terminal 183.Connection terminal 181 can be connected to substrate 18.Flexible cable 182 be connected with each other have connection terminal 181 and
183.Connection terminal 183 can be with being arranged at the substrate connection of move portion 20.
As shown in figure 9, display part 21 is electrically connected to frame 10 in a manner of it can be moved relative to frame 10.By
This, can pair supply electric power of display part 21 relatively moved together with move portion 20 relative to frame 10, and can
Display part 21 is set to send and receive electric signal.
(configuration example of controller and fan)
Next, 10~Figure 12 of reference picture, illustrate the configuration example of the controller 192 and 193 of microscopie unit 100.
As shown in Figure 10, microscopie unit 100 possesses substrate 19.Substrate 19 be provided with power supply 191, controller 192 with
And multiple fans 193.Substrate 19 is configured at the lower section (reference picture 5) of the inside of frame 10.Substrate 19 is configured to level.Power supply
191 are supplied to electric power from outside.Each several part of the power supply 191 by the power supply of supply to microscopie unit 100.For example, power supply
The supply electric powers such as 191 pairs of light sources 13, photographing element 14, display part 21, drive division 10a, controller 192, fan 193.
Controller 192 controls each several part of microscopie unit 100.For example, controller 192 controls the light carried out by light source 13
Irradiation.Driving of the controller 192 to drive division 10a is controlled.Controller 192 according to the control carried out by control unit 200,
The each several part of microscopie unit 100 is controlled.Controller 192 is configured at and is configured with object lens in the inside of frame 10
12nd, the region (reference picture 5) that the region of light source 13 and photographing element 14 separates.Specifically, separated by separator 10c.
Substrate 18 is configured with above separator 10c.Substrate 19 is configured with below separator 10c.Thereby, it is possible to by controller
192 isolate and configure with object lens 12, light source 13 and photographing element 14, so can suppress the heat transfer of controller 192 to thing
Mirror 12, light source 13 and photographing element 14.The component that the region by Configuration Control Unit 192 separates can be utilized to improve object lens
12nd, the light-proofness of light source 13 and photographing element 14.
As shown in figs.10 and 11, fan 193 is configured to cool down the inside of frame 10.Specifically, wind
Fan 193 is configured to that the air from outside is taken into frame 10 by driving, makes its circulation, and arrange from exhaust outlet 193a
Go out.A pair of fans 193 are provided with along the X direction.Fan 193 is arranged on the lower side of the rear side (Y2 directions side) of frame 10
(Z2 directions side).The stopping during the shooting of the sample carried out by photographing element 14 of fan 193 acts.Thereby, it is possible to prevent
Be delivered to photographing element 14, sample setting unit 11 etc. in the vibration caused by fan 193 during shooting, thus can precision it is good
Ground images to sample.
As shown in figure 12, controller 192 is connected to control unit 200.Control unit 200 possesses processing unit 201, storage part 202
And interface 203.Control unit 200 connects input unit 204.Controller 192 is connected to processing unit 201 via interface 203.Processing unit
201 for example including CPU, and the action to microscopie unit 100 is controlled.Storage part 202 is for example including HDD (hard drives
Device), SSD (solid-state drive) etc., preserve the program performed by control unit 200, information.Input unit 204 accepts the operation of user.
Input unit 204 is such as including mouse, keyboard.Input unit 204 is connected to processing unit 201 via interface 203.
(structure of the microscopie unit of the 1st variation)
Next, reference picture 13, illustrate the structure of the microscopie unit 400 of the 1st variation.
As shown in figure 13, microscopie unit 400 possesses frame 410 and move portion 420.Frame 410 is provided with sample
Setting unit 411.Display part 421 is provided integrally with move portion 420.As shown in figure 13, move portion 420 is configured in frame
410 front-surface side (Y1 directions side).Move portion 420 is with along the plane vertical with the setting face of frame 410, (XZ is put down
Face) extension writing board shape.
Move portion 420 is configured to be moved to shading position by sliding along above-below direction (Z-direction) and open wide
Position.In addition, the moving direction of move portion 420 and the face direction that display part 421 is extended are almost parallel.That is, aobvious
In the case of showing that portion 421 is arranged obliquely with having predetermined angle relative to above-below direction (Z-direction), the movement of move portion 420
Direction also turns into has the inclined direction in predetermined angle ground relative to above-below direction (Z-direction).As shown in figure 13, in move portion
In the case that 420 are located at open position, the front side (Y1 directions side) of sample setting unit 411 is opened.Sample setting unit 411 is matched somebody with somebody
Put in the X1 directions side of frame 410.Sample setting unit 411 is configured in the upside of frame 410 on above-below direction (Z-direction)
(Z1 directions side).
(structure of the microscopie unit of the 2nd variation)
Next, reference picture 14, illustrate the structure of the microscopie unit 500 of the 2nd variation.
As shown in figure 14, microscopie unit 500 possesses frame 510 and move portion 520.Frame 510 is provided with sample
Setting unit 511.Display part 521 is provided integrally with move portion 520.As shown in figure 14, move portion 520 is configured in frame
510 front-surface side (Y1 directions side).Move portion 520 is with along the plane vertical with the setting face of frame 510, (XZ is put down
Face) extension writing board shape.
Move portion 520 is configured to be moved to shading position by sliding along horizontal direction (X-direction) and open wide
Position.As shown in figure 14, in the case where move portion 520 is located at open position, front side (the Y1 directions of sample setting unit 511
Side) it is opened.Sample setting unit 511 being capable of direction (Y1 directions) movement forwards.Thus, when making sample setting unit 511 forward
During Fang Yidong, the top (Z1 directions) of sample setting unit 511 is also opened.Sample setting unit 511 configures the X1 in frame 510
Direction side.Sample setting unit 511 is configured on above-below direction (Z-direction) in the upside of frame 510 (Z1 directions side).
(structure of the microscopie unit of the 3rd variation)
Next, reference picture 15 and Figure 16, illustrate the structure of the microscopie unit 600 of the 3rd variation.
As shown in figure 15, microscopie unit 600 possesses frame 610 and move portion 620.Frame 610 is provided with sample
Setting unit 611.Display part 621 is provided integrally with move portion 620.As shown in figure 15, move portion 620 is configured in frame
610 front-surface side (Y1 directions side).Move portion 620 is with along the plane vertical with the setting face of frame 610, (XZ is put down
Face) extension writing board shape.
Move portion 620 is configured to be moved to shading position by sliding along horizontal direction (X-direction) and open wide
Position.As shown in figure 15, in the case where move portion 620 is located at open position, front side (the Y1 directions of sample setting unit 611
Side) it is opened.Sample setting unit 611 is configured in the X1 directions side of frame 610.Sample setting unit 611 is in above-below direction (Z side
To) on configuration frame 610 center near.
As shown in figure 16, object lens 12, light source 13, photographing element 14, actuating are configured with the substrate 18 of microscopie unit 600
Device 611a, the 1st optical element 15, filter 16a, the 2nd optical element 16b and lens 16h.Object lens 12 are configured at sample setting
The lower section (Z2 directions) in portion 611.Sample setting unit 611 is configured between the setting face of frame 10 and sample setting unit 611
Distance D1 is longer than the length D2 of the optical axis direction of object lens 12.Thereby, it is possible to the optical axis for being configured to object lens 12 to be in above-below direction (Z
Direction), so in the case where sample setting unit 611 is set into horizontal direction, it can easily make object lens 12 in optical axis direction
On close to sample.
(structure of the microscopie unit of the 4th variation)
Next, reference picture 17 and Figure 18, illustrate the structure of the microscopie unit 700 of the 4th variation.
As shown in figure 17, microscopie unit 700 possesses frame 710 and move portion 720.Frame 710 is provided with sample
Setting unit 711.Display part 721 is provided integrally with move portion 720.As shown in figure 17, move portion 720 is configured in frame
710 front-surface side (Y1 directions side).Move portion 720 is with along the plane vertical with the setting face of frame 710, (XZ is put down
Face) extension writing board shape.
Move portion 720 is configured to be moved to shading position by sliding along horizontal direction (X-direction) and open wide
Position.As shown in figure 17, in the case where move portion 720 is located at open position, front side (the Y1 directions of sample setting unit 711
Side) it is opened.Sample setting unit 711 is configured in the X1 directions side of frame 710.Sample setting unit 711 is in above-below direction (Z side
To) on configuration in the downside of frame 710 (Z2 directions side).
As shown in figure 18, object lens 12, light source 13, photographing element 14, actuating are configured with the substrate 18 of microscopie unit 700
Device 711a, the 1st optical element 15, filter 16a, the 2nd optical element 16b and lens 16h.Object lens 12 are configured at sample setting
The top (Z1 directions) in portion 711.Sample setting unit 711 is configured between the upper surface of frame 10 and sample setting unit 711
Distance D3 is longer than the length D2 of the optical axis direction of object lens 12.
In addition, both it had been configured to rotate to be moved to shading position and open wide relative to frame by move portion
Position, can also be configured to rotate and go forward side by side relative to frame by move portion it is mobile and be moved to shading position and
Open position.
(configuration example of light source)
Next, reference picture 19, illustrate the configuration example of light source 13.
As shown in figure 19, light source 13 include the 1st light source 131a, the 2nd light source 131b, speculum 132a, dichronic mirror 132b with
And fan 133.1st light source 131a and the 2nd light source 131b exports the light of mutually different wavelength.1st light source 131a outputs are special
The light of fixed wavelength region.2nd light source 131b exports the light of the specific wavelength region different from the 1st light source 131a.1st light source
131a and the 2nd light source 131b can export laser respectively.In addition, the light of the 1st light source 131a and the 2nd light source 131b outputs was both
Can be the light of visible region or the light in the black light region of region of ultra-red or ultraviolet region.
Reflected by the 1st light source 131a light exported by speculum 132a, and transmit dichronic mirror 132b, it is defeated from light source 13
Go out.Reflected by dichronic mirror 132b by the 2nd light source 131b light exported, exported from light source 13.Due to these, from the 1st light source 131a
The light of output and from the 2nd light source 131b output light exported with optical axis state consistent with each other from light source 13.
1st light source 131a turns into a part for multiple pigments for making to be combined with sample the light of the wavelength of state of activation
It is irradiated to sample.The light that 2nd light source 131b will turn into the wavelength of unactivated state for becoming multiple pigments of state of activation
It is irradiated to sample.Then, photographing element 14 is configured to the pigment hair from a part in multiple pigments, as state of activation
The light gone out is photographed.Luminous thereby, it is possible to the pigment according to the part for turning into state of activation images to image.Take the photograph
Element 14 is configured to repeatedly image sample.Then, display part 21 is configured to display to being imaged by photographing element 14
The image that multiple images are synthesized into.
A part in the multiple pigments combined with sample lights.Pigment is combined for each molecule of cell.So
Afterwards, for making pigment excite the fluoroscopic image repeatedly imaged successively, precision obtains the fluorescent places of pigment and weighed well
Folded image.In this case, the fluorescent places of pigment are obtained well using 1 molecule as unit precision.By overlapping according to this
The fluoroscopic image that the positional precision of every 1 molecule is got, the super-resolution image of the boundary more than resolution can be obtained.
Fan 133 is configured in the inside of frame 10, is set to be cooled down to light source 13.Specifically,
Fan 133 is configured to produce the flowing of air on the periphery of light source 13 by driving, removes from hot caused by light source 13.Fan
The 133 stopping actions during the shooting of the sample carried out by photographing element 14.Thereby, it is possible to prevent the fan during shooting
Vibration caused by 133 is delivered to photographing element 14, sample setting unit 11 etc., thus can precision sample is taken the photograph well
Picture.
(the display picture example of display part)
Next, reference picture 20, illustrates an example for being shown in the display picture of display part 21.
In the display picture example shown in Figure 20, in the case of being imaged in microscopie unit 100 to sample,
Show and parse with display in the display control of display part 21.Control includes that camera views are shown, camera parameter is set with showing
Fixed display, sample setting unit moving operation is shown, camera parameter monitor is shown and move portion opening and closing operations are shown.Parsing is used
Display includes super-resolution image and shown and the setting display of super-resolution image analytic parameter.
In camera views are shown, the real-time camera views imaged by photographing element 14 are shown.In camera parameter
In setting display, the camera parameter of the shooting processing in microscopie unit 100 is shown.In camera parameter setting display, such as
Show display that the power of the laser for being exported from light source 13 adjusts etc..In sample setting unit moving operation is shown, such as
Show the operation screen for moving the position of sample setting unit 11.In camera parameter monitor is shown, monitor is shown
Information.In camera parameter monitor is shown, for example, the position of display sample setting unit 11, light source 13 laser power, take the photograph
The temperature of element 14, camera time, time untill shooting terminates etc..In move portion opening and closing operations are shown, such as
Show the operation screen for making move portion 20 be moved to shading position and open position.
In super-resolution image is shown, super-resolution image is shown.In addition, the data of super-resolution image have it is thousands of
The size of the square left and right of square~tens of thousands of pixel of pixel.Here, the size of display part 21 is bigger, it can more increase super-resolution figure
Display area as shown in, it is advantageous to the area for display part 21 is big.In the setting display of super-resolution image analytic parameter,
Show the analytic parameter of super-resolution shooting.In the setting display of super-resolution image analytic parameter, such as show from light source 13
The irradiation sequence of the laser of output, image number etc..
(image pickup processing action)
Reference picture 21, illustrate the image pickup processing action of microscopic system 300.
First, in Figure 21 step S1, when the operation by user, when shooting button is set as ON, in step s 2,
Control unit 200 enters to exercise the control of the driving stopping of fan 193 and fan 133 via controller 192.In step s3, control
The shooting of sample of the portion 200 processed to being carried out by photographing element 14 is controlled.Sample is imaged multiple.For example, in step s3,
Sample is imaged into several thousand sheets~tens of thousands of or so.
In step s 4, after shooting terminates, control unit 200 enters to exercise fan 193 and fan via controller 192
The control of 133 drivings.Afterwards, image pickup processing action is terminated.
(super-resolution image shooting processing action)
Reference picture 22, illustrate the super-resolution image shooting processing action of microscopic system 300.
First, in Figure 22 step S11, the illumination that control unit 200 enters to be about to the 1st wavelength via controller 192 is mapped to
The control of sample.Specifically, it is irradiated to sample from the light of the 2nd light source 131b outputs.Thus, the iridescent combined with sample
Element does not activate.That is, the fluorchrome combined with sample is by delustring.In step s 12, control unit 200 is via controller
192 illumination for entering to be about to the 2nd wavelength are mapped to the control of sample.Specifically, it is irradiated to examination from the light of the 1st light source 131a outputs
Material.Thus, the fluorchrome for the part that activation is combined with sample.
In step s 13, control unit 200 fluorchrome of the part from activation is excited using photographing element 14
The control that is imaged of light.In step S14, control unit 200 judge be by the image that photographing element 14 is imaged and got
It is no to conform to a predetermined condition.If met, terminate super-resolution image shooting processing, if do not met, return to step
S11, step S11~S14 processing is repeated.
(super-resolution image makes processing action)
Reference picture 23, illustrate that the super-resolution image of microscopic system 300 makes processing action.
First, in Figure 23 step S21, control unit 200 extracts the bright spot of the fluorescence of each image of shooting.It is specific and
Speech, on the image of shooting, pass through the bright spot of Gauss curve fitting extraction fluorescence.In step S22, control unit 200 is obtained and extracted
Bright spot coordinate.That is, obtain the position of the pixel of the bright spot on image.Specifically, obtained in 2 dimensional planes each bright
The coordinate of point.Then, the region of the bright spot on image is obtained.Specifically, on each fluorescence area on the image of shooting,
By Gauss curve fitting in the case where preset range has obtained the matching with reference waveform, the bright spot of width corresponding with the scope
Region is assigned to each bright spot.On in the bright spot of the fluorescence area of 1 Point matching, distributing the width of the lowest class with reference waveform
Narrow spot zone.
In step S23, control unit 200 carries out overlapping to the spot zone of each image.Then, control unit 200 is by making
The spot zone of each bright spot got is overlapping on all images, thus makes super-resolution image.Afterwards, super-resolution is terminated
Rate image making is handled.
In addition, embodiment of disclosure should be considered as in all aspects be illustrate, and and it is nonrestrictive.This
The scope of invention is shown by the explanation of above-mentioned embodiment, but is shown by claims, so comprising with power
All changes (variation) in sharp claim impartial meaning and scope.
For example, it is also possible to the cap for covering sample setting unit 11, such as baffle plate are provided separately with move portion 20.
In this case, can also with the mobile linkage of move portion 20 and cap (baffle plate) is closed and covers sample setting unit 11.At this
In the case of, both double shading can be carried out using move portion 20 and cap (baffle plate), and the side of move portion 20 can also opened wide
In the case of, shading only is carried out to sample setting unit 11 by cap (baffle plate).
Alternatively, it is also possible to not set light source in the inside of frame 10, light source can also be set in the outside of frame 10.
Alternatively, it is also possible to be formed as such as the knot using object lens downward without using object lens 12 upward
Structure.
Claims (24)
1. a kind of microscopie unit, possesses：
Sample setting unit, for setting sample；
Image pickup part, the sample for being arranged at the sample setting unit is imaged；
Frame, the sample setting unit is set, and image pickup part configuration is internally；
Display part, show the image imaged by the image pickup part；And
Move portion, the display part is provided integrally with, can be relatively moved relative to the sample setting unit.
2. microscopie unit according to claim 1, wherein,
The move portion is configured to relatively slide relative to the frame, so as to carry out phase relative to the sample setting unit
To movement.
3. microscopie unit according to claim 1, wherein,
The move portion is configured to be moved to the 1st position for covering the sample setting unit and open wide the sample to set
2nd position in portion.
4. microscopie unit according to claim 1, wherein,
The microscopie unit is also equipped with cap, and the cap covers in linkage with movement of the move portion to the sample setting unit
Cover the sample setting unit.
5. microscopie unit according to claim 1, wherein,
The move portion includes：Horizontal plane, extend in the horizontal direction, cover from above the sample setting unit；And intersect
Face, link with the horizontal plane, upwardly extended in the side intersected with the horizontal plane, described in side side covering from horizontal direction
Sample setting unit,
The display part is configured at the cross facet.
6. microscopie unit according to claim 5, wherein,
The sample setting unit is arranged at the frame in the low position of the horizontal plane than the move portion.
7. microscopie unit according to claim 5, wherein,
The face that the cross facet is configured to cover a side side of the horizontal direction of the frame is overall,
The display part is configured at the substantially overall of the cross facet.
8. microscopie unit according to claim 1, wherein,
The microscopie unit is also equipped with substrate, and the substrate is configured in the inside of the frame, is configured with the image pickup part,
The image pickup part includes object lens, and the sample that the object lens are configured to optical axis and the setting sample of the sample setting unit is set
It is substantially vertical to put face,
The substrate is configured to almost parallel with the optical axis of the object lens.
9. microscopie unit according to claim 1, wherein,
The display part is configured at the move portion in a manner of having predetermined gradient relative to vertical,
The move portion is configured to set relative to the sample with the state that the display part has the predetermined gradient
Portion is relatively moved.
10. microscopie unit according to claim 1, wherein,
The sample setting unit is configured at the upper surface of the approximate horizontal frame.
11. microscopie unit according to claim 1, wherein,
The sample setting unit configures on the direction that the move portion is relatively moved relative to the sample setting unit
Near the end of the frame.
12. microscopie unit according to claim 1, wherein,
The move portion is configured to be relatively moved in the horizontal direction relative to the sample setting unit.
13. microscopie unit according to claim 1, wherein,
The microscopie unit possesses fan, and the fan arrangement is in the inside of the frame, in the frame
Portion is cooled down,
The fan is configured at and is configured with the region that the region of the image pickup part separates in the inside of the frame, by institute
Stopping acts during stating the shooting of the sample of image pickup part progress.
14. microscopie unit according to claim 1, wherein,
The image pickup part includes light source, object lens, photographing element, the 1st optical element and the 2nd optical element, the 1st optics member
Part makes the light from light source irradiation be reflected on the optical axis direction of the object lens, transmits the light from the sample, and the described 2nd
Optical element makes the light from the sample be reflected towards the photographing element.
15. microscopie unit according to claim 1, wherein,
The image pickup part includes：1st light source, swash for a part for multiple pigments for making to be combined with the sample to be turned into
The illumination of the wavelength of state living is mapped to the sample；And the 2nd light source, for by for becoming the multiple of state of activation
The illumination that pigment turns into the wavelength of unactivated state is mapped to the sample.
16. microscopie unit according to claim 15, wherein,
The image pickup part is configured to being carried out from the light sent as a part of pigment of state of activation in the multiple pigment
Photography.
17. microscopie unit according to claim 15, wherein,
The image pickup part is configured to repeatedly image the sample,
The display part is configured to the image that display is synthesized into multiple images imaged by the image pickup part.
18. microscopie unit according to claim 1, wherein,
The frame has inner space long in one direction,
The image pickup part includes object lens, light source and photographing element,
It is substantially vertical with the length direction of the frame that the object lens are configured to optical axis,
The light source and the photographing element are configured same on the length direction of the frame relative to the object lens
Side.
19. microscopie unit according to claim 1, wherein,
The microscopie unit is also equipped with：
Drive division, the move portion is set to be relatively moved relative to the sample setting unit；And
Controller, the drive division is controlled,
The controller is configured at and is configured with the region that the region of the image pickup part separates in the inside of the frame, forms
The move portion is relatively moved for the operation according to user by the drive division.
20. microscopie unit according to claim 1, wherein,
The microscopie unit is also equipped with controller, the irradiation for the light that controller control is carried out by the image pickup part,
The controller is configured at and is configured with the region that the region of the image pickup part separates in the inside of the frame.
21. microscopie unit according to claim 3, wherein,
The sample setting unit is so that the side that the part in addition to the direction side of horizontal direction and upside is surrounded by wall
Formula is arranged at the upper surface of the frame with concavity, is configured in the case where the move portion is located at the 2nd position, opens
Upside and one direction side of horizontal direction are opened,
One direction side of horizontal direction of the display part configuration in the move portion.
22. microscopie unit according to claim 1, wherein,
The image pickup part is included upward to the immersion objective of configuration.
23. a kind of microscopic system, possess the control unit of microscopie unit and the control microscopie unit, wherein,
The microscopie unit possesses：
Sample setting unit, for setting sample；
Image pickup part, the sample for being arranged at the sample setting unit is imaged；
Frame, the sample setting unit is set, and image pickup part configuration is internally；
Display part, show the image imaged by the image pickup part；And
Move portion, the display part is provided integrally with, can be relatively moved relative to the sample setting unit.
24. a kind of image capture method, it is the image capture method for the microscopie unit for being provided integrally with display part, the image capture method bag
Include：
The display part is set to be relatively moved relative to the sample setting unit of the microscopie unit and open wide the sample and set
The process for putting portion；
Make the display part be relatively moved relative to the sample setting unit and cover to be provided with the sample of sample and set
The process for putting portion；And
By the microscopie unit to being arranged at the examination of the sample setting unit in the state of the sample setting unit is capped
Expect the process imaged.
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| JP2016-177891 | 2016-09-12 | ||
| JP2016177891A JP6680653B2 (en) | 2016-09-12 | 2016-09-12 | Microscope device, microscope system, and imaging method |
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| US (1) | US10585275B2 (en) |
| EP (1) | EP3293560B1 (en) |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110967821A (en) * | 2018-09-28 | 2020-04-07 | 希森美康株式会社 | Microscope device |
| CN110967820A (en) * | 2018-09-28 | 2020-04-07 | 希森美康株式会社 | Microscope system control method, microscope system, and recording medium |
| CN113382571A (en) * | 2020-02-25 | 2021-09-10 | 徕卡仪器（新加坡）有限公司 | Microscope stand, and module and housing for a microscope stand |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6680653B2 (en) * | 2016-09-12 | 2020-04-15 | シスメックス株式会社 | Microscope device, microscope system, and imaging method |
| JP2021083431A (en) | 2019-11-29 | 2021-06-03 | シスメックス株式会社 | Cell analysis method, cell analysis device, cell analysis system and cell analysis program |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1700051A (en) * | 2004-05-21 | 2005-11-23 | 株式会社其恩斯 | Fluorescence microscope |
| US20080116395A1 (en) * | 2004-09-03 | 2008-05-22 | Kei Tsuyuki | Dark box apparatus for fluoroscopy, fluoroscopy system, and fluroscopy method |
| US20090046358A1 (en) * | 2005-11-16 | 2009-02-19 | Olympus Corporation | Optical microscope apparatus |
| CN104375265A (en) * | 2014-10-09 | 2015-02-25 | 苏州怡信光电科技有限公司 | High definition image type measurement instrument |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3900252A (en) * | 1973-10-31 | 1975-08-19 | Redken Laboratories Inc | Method and apparatus for analyzing hair structure |
| US4206966A (en) * | 1978-10-23 | 1980-06-10 | Redken Laboratories, Inc. | Projection microscope with film holder |
| JP2603486Y2 (en) * | 1993-12-20 | 2000-03-13 | オリンパス光学工業株式会社 | microscope |
| CA2164369C (en) * | 1995-12-04 | 2006-01-24 | Roman Baldur | Portable fired cartridge imaging apparatus |
| JP4789454B2 (en) * | 2004-12-03 | 2011-10-12 | 株式会社キーエンス | Fluorescence microscope |
| JP2007071803A (en) * | 2005-09-09 | 2007-03-22 | Hitachi High-Technologies Corp | Defect observation method and its apparatus |
| WO2008048612A2 (en) * | 2006-10-17 | 2008-04-24 | Hnuphotonics | Miniature microscope camera |
| JP5621259B2 (en) * | 2007-09-03 | 2014-11-12 | 株式会社ニコン | Microscope equipment |
| JP2010102332A (en) * | 2008-09-29 | 2010-05-06 | Nikon Corp | Photoactivation localization microscope and photoactivation localization observation method |
| JP2010169736A (en) * | 2009-01-20 | 2010-08-05 | Olympus Corp | Microscope system |
| KR100942195B1 (en) | 2009-10-14 | 2010-02-11 | 주식회사 나노엔텍 | Fluorescence microscope and remote control system thereof |
| JP5747690B2 (en) * | 2011-07-04 | 2015-07-15 | 株式会社ニコン | Microscope device and image forming method |
| US9531992B2 (en) * | 2013-03-26 | 2016-12-27 | Sharp Kabushiki Kaisha | Display apparatus, portable terminal, television receiver, display method, program, and recording medium |
| TWI494596B (en) * | 2013-08-21 | 2015-08-01 | Miruc Optical Co Ltd | Portable terminal adaptor for microscope, and microscopic imaging method using the portable terminal adaptor |
| JP2015084060A (en) | 2013-10-25 | 2015-04-30 | 株式会社キーエンス | Microscope apparatus |
| JP6325816B2 (en) * | 2013-12-27 | 2018-05-16 | 株式会社キーエンス | Magnification observation apparatus, magnification image observation method, magnification image observation program, and computer-readable recording medium |
| GB2524488B (en) * | 2014-03-24 | 2018-05-02 | Iolight Ltd | Digital Microscope |
| JP6680653B2 (en) * | 2016-09-12 | 2020-04-15 | シスメックス株式会社 | Microscope device, microscope system, and imaging method |
-
2016
- 2016-09-12 JP JP2016177891A patent/JP6680653B2/en active Active
-
2017
- 2017-09-04 AU AU2017221890A patent/AU2017221890B2/en active Active
- 2017-09-08 EP EP17190105.1A patent/EP3293560B1/en active Active
- 2017-09-11 CN CN201710816053.4A patent/CN107817599A/en active Pending
- 2017-09-12 US US15/701,781 patent/US10585275B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1700051A (en) * | 2004-05-21 | 2005-11-23 | 株式会社其恩斯 | Fluorescence microscope |
| US20080116395A1 (en) * | 2004-09-03 | 2008-05-22 | Kei Tsuyuki | Dark box apparatus for fluoroscopy, fluoroscopy system, and fluroscopy method |
| US20090046358A1 (en) * | 2005-11-16 | 2009-02-19 | Olympus Corporation | Optical microscope apparatus |
| CN104375265A (en) * | 2014-10-09 | 2015-02-25 | 苏州怡信光电科技有限公司 | High definition image type measurement instrument |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110967821A (en) * | 2018-09-28 | 2020-04-07 | 希森美康株式会社 | Microscope device |
| CN110967820A (en) * | 2018-09-28 | 2020-04-07 | 希森美康株式会社 | Microscope system control method, microscope system, and recording medium |
| CN110967820B (en) * | 2018-09-28 | 2022-11-15 | 希森美康株式会社 | Microscope system control method, microscope system, and recording medium |
| CN110967821B (en) * | 2018-09-28 | 2023-08-11 | 希森美康株式会社 | Microscope device |
| CN113382571A (en) * | 2020-02-25 | 2021-09-10 | 徕卡仪器（新加坡）有限公司 | Microscope stand, and module and housing for a microscope stand |
| CN113382571B (en) * | 2020-02-25 | 2023-12-12 | 徕卡仪器（新加坡）有限公司 | Microscope stand, module for a microscope stand and housing |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6680653B2 (en) | 2020-04-15 |
| US10585275B2 (en) | 2020-03-10 |
| US20180074308A1 (en) | 2018-03-15 |
| AU2017221890B2 (en) | 2021-03-18 |
| EP3293560A1 (en) | 2018-03-14 |
| EP3293560B1 (en) | 2021-04-07 |
| JP2018044997A (en) | 2018-03-22 |
| AU2017221890A1 (en) | 2018-03-29 |
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Application publication date: 20180320 |