CN1078140A - The preparation method of high bioavailability ibuprofen tablet - Google Patents
The preparation method of high bioavailability ibuprofen tablet Download PDFInfo
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- CN1078140A CN1078140A CN 92103338 CN92103338A CN1078140A CN 1078140 A CN1078140 A CN 1078140A CN 92103338 CN92103338 CN 92103338 CN 92103338 A CN92103338 A CN 92103338A CN 1078140 A CN1078140 A CN 1078140A
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- preparation
- ibuprofen tablet
- ibuprofen
- high bioavailability
- direct compression
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention is the high biological availability preparation method of analgesic, antiinflammatory, analgesic drug ibuprofen tablet.Belong to pharmaceutical preparation technology.
Description
The invention belongs to a kind of pharmaceutical preparation technology.
Ibuprofen is an anti inflammation and heat resolution analgesic preferably, owing to be insoluble in water, exists the low problem of bioavailability.Before 85 years, homemade ibuprofen tablet curative effect is generally reflected not as imported product in clinical treatment unit, thereby causes a large amount of import ibuprofen tablet to flow into the domestic market.February nineteen ninety, Shandong Xinhua Pharmaceutical Factory was entrusted by national medical industry company, and pharmaceutical factory from ibuprofen tablet to the whole nation that respectively produce has issued the prescription and the technology of the bioavailability Xinhua pharmaceutical factory development suitable with external best brand of product.Though this prescription and technology bioavailability are suitable with external product, in this prescription overdose select three kinds of new adjuvants that price comparison is high for use, and also exist the sticking phenomenon in producing.
The objective of the invention is on the basis of guaranteeing the high bioavailability of medicine, adopt special treatment method, simplify technology preparation, reduce cost of supplementary product, release the production technology and the prescription of the higher ibuprofen tablet of a kind of overall economic benefit to each pharmaceutical factory.
The preparation process of ibuprofen tablet of the present invention is, direct compression of full-powder, its method for making is: ibuprofen is crossed behind 60 mesh sieves and (two kinds) mix homogeneously such as amylum pregelatinisatum, carboxymethyl starch sodium, microcrystalline Cellulose, lactose, micropowder silica gel, magnesium oxide, magnesium stearate, Pulvis Talci at least, direct compression, the well-established law coating gets final product.
The preparation prescription and the technology of the production ibuprofen tablet that the present invention is given, its advantage are to compare (1) bioavailability equivalence with pharmaceutical factory of Xinhua with technology to the prescription of whole nation issue; (2) technology is easy, has saved operations such as granulation, drying, granulate; (3) prescription is simple, and cost of supplementary product is cheap, and one ton of (5,000,000) ibuprofen tablet of every production can be saved 11500 yuans of cost of supplementary product; (4) sticking not.
Optimised process of the present invention is: (every contains ibuprofen 0.2g, and this prescription can be produced 200,000)
Ibuprofen 40kg
Amylum pregelatinisatum 2kg
Microcrystalline Cellulose 2kg
Pulvis Talci 1.5kg
Magnesium stearate 0.5kg
Technological operation: take by weighing ibuprofen, amylum pregelatinisatum, microcrystalline Cellulose, Pulvis Talci, magnesium stearate, cross 60 mesh sieves, mix homogeneously, direct compression, the well-established law coating gets final product.
Claims (3)
1, the preparation method of high bioavailability ibuprofen tablet is characterized in that direct compression of full-powder, preparation process by prepare burden, sieve, operation such as mixing, tabletting, coating finishes.
2, direct compression of full-powder technology as claimed in claim 1, the used adjuvant that it is characterized in that preparing burden should be selected amylum pregelatinisatum for use, carboxymethyl starch sodium, microcrystalline Cellulose, lactose etc. are wherein at least a; At least a in micropowder silica gel, magnesium oxide, magnesium stearate, the Pulvis Talci, as binding agent, stripping promoter and fluidizer.
3, pharmaceutical adjunct as claimed in claim 2 needs before it is characterized in that using to use after 2 hours in oven dry under 50～115 ℃ of conditions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92103338 CN1078140A (en) | 1992-04-27 | 1992-04-27 | The preparation method of high bioavailability ibuprofen tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92103338 CN1078140A (en) | 1992-04-27 | 1992-04-27 | The preparation method of high bioavailability ibuprofen tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1078140A true CN1078140A (en) | 1993-11-10 |
Family
ID=4940157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92103338 Pending CN1078140A (en) | 1992-04-27 | 1992-04-27 | The preparation method of high bioavailability ibuprofen tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1078140A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013004123A1 (en) * | 2011-07-01 | 2013-01-10 | Sino-American Tianjin Smithkline And French Lab., Ltd | Ibuprofen chewable tablet |
-
1992
- 1992-04-27 CN CN 92103338 patent/CN1078140A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013004123A1 (en) * | 2011-07-01 | 2013-01-10 | Sino-American Tianjin Smithkline And French Lab., Ltd | Ibuprofen chewable tablet |
| AP3309A (en) * | 2011-07-01 | 2015-06-30 | Sino American Tianjin Smithkline And French Lab Ltd | Ibuprofen chewable tablet |
| RU2567050C2 (en) * | 2011-07-01 | 2015-10-27 | Сино-Американ Тяньцзинь Смитклайн Энд Френч Лаб., Лтд | Ibuprofene chewing tablet |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |