CN107812185A - A kind of ultra tiny water-in-oil-in-water emulsion adjuvant - Google Patents
A kind of ultra tiny water-in-oil-in-water emulsion adjuvant Download PDFInfo
- Publication number
- CN107812185A CN107812185A CN201610827188.6A CN201610827188A CN107812185A CN 107812185 A CN107812185 A CN 107812185A CN 201610827188 A CN201610827188 A CN 201610827188A CN 107812185 A CN107812185 A CN 107812185A
- Authority
- CN
- China
- Prior art keywords
- oil
- water
- ether
- emulsion adjuvant
- water emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention discloses a kind of ultra tiny water-in-oil-in-water emulsion adjuvant, and it includes the component of following mass percent：White oil is 50%~68%, mineral oil is 21%~29%, Tween 80 is 1.5%~2.5%, mannitol oleate is 2%~2.5%, polyoxyethylene oleic acid ether-ether 3%~11%, non-ionic block copolymer L180 are 2.5%~9%, auxiliary agent 1%~2.5%.The invention provides a kind of brand-new water-in-oil-in-water emulsion adjuvant formula, the vacancy in the domestic field can be filled up, production cost can effectively be reduced, increase enterprise profit, strengthen enterprise competitiveness, there is fabulous Social benefit and economic benefit, the industries such as biological products, daily-use chemical industry can be driven to reform production technology, especially concerning the poultry industry of national economy, the extensive use of quality-high and inexpensive high-quality vaccine ground, due contribution is being made further to improve people's living standard.
Description
Technical field
The present invention relates to a kind of emulsification adjuvant, belongs to vaccine emulsification adjuvant technical field, refers in particular to a kind of ultra tiny water
Bag water-in-oil emulsion adjuvant.
Background technology
In nature, when two kinds of immiscible liquid, one kind is scattered in shape in another kind with particulate (drop or liquid crystal)
Into system be referred to as emulsion, the liquid of emulsus claims emulsion.Wide variety of emulsion has oily emulsion and water-based in industry at present
Emulsion, also known as water-in-oil emulsion (abbreviation O/W types) and oil-in-water emulsion (abbreviation w/o type), they are single phase emulsion.And two-phase
Emulsion or multiple emulsion, it is a kind of shared complex system of w/o type and O/W type emulsion, conventional has water-in-oil-in water (W/O/
W types) and Water-In-Oil oil-in (O/W/O types).Single phase emulsion performance is each variant, respectively has its own the limitation of use range, and
Biphasic emulsion can integrate their advantages, make it have fine quality on the basis of above-mentioned two kinds of single phase emulsion shortcomings are removed
And performance.
Efficient biphase emulsification adjuvant is mainly by high-quality mineral drug is oily and a variety of special functional surfactants, warp
The multiple chemical process refining such as mixing, reaction, refined, filtering forms, and has and good emulsify, disperses, permeating, be color inhibition, anti-
The characteristics such as aging, modest viscosity, stability of emulsion height, security height, its great advantage are exactly stable performance and easy to use, only
Need to mix with a certain proportion of water, high-quality biphasic emulsion is can obtain through being sufficiently stirred.The stability of emulsion is high, in refrigerator
Place 1 year it is not stratified, never degenerate, this is that single phase emulsion is difficult to.Its good characteristic is recognized for World Developed Countries
Can, it is widely used in medical pharmaceutical injection emulsion formulations, poultry vaccine and high-grade daily-use cosmetics etc..
At present, domestic high-end vaccine mainly uses the efficient biphase emulsification adjuvant of French SEPPLC companies.It is not wide
General the reason for being applied to domestic every profession and trade (particularly in pharmaceuticals industry), mainly caused by its expensive price, its price per ton is high
Up to more than 120,000 yuan.At home, simply used at present in the vaccine of animal husbandry part, because cost is too high, still not huge
It is widely applied in domestic fowl farming.Current most of poultry vaccine can only still use single phase emulsion, have a strong impact on poultry vaccine row
The development level of industry.A kind of efficient biphase emulsification adjuvant is developed, reduces its production cost, so as to which its market price be greatly lowered
Lattice, break the trade monopoly of overseas enterprise, promote the development of China Vaccine industry, promote the development of the industries such as herding, poultry, be exactly
The technical problems to be solved by the invention and the purpose to be reached.
The content of the invention
It is an object of the invention to overcome shortcoming and deficiency of the prior art, there is provided a kind of ultra tiny W/O/W breast
Change adjuvant, the emulsification adjuvant can effectively reduce production cost, increase enterprise profit, strengthen enterprise competitiveness, can fill up state
The vacancy in the interior field, there is fabulous Social benefit and economic benefit.
To achieve these goals, the present invention realizes according to following technical scheme：
A kind of ultra tiny water-in-oil-in-water emulsion adjuvant, it includes the component of following mass percent：White oil is 50%
~68%, mineral oil is 21%~29%, Tween 80 is 1.5%~2.5%, mannitol oleate is 2%~2.5%, polyoxy
Ethene oleic acid ether-ether 3%~11%, non-ionic block copolymer L180 are 2.5%~9%, auxiliary agent 1%~2.5%.
Further, a kind of ultra tiny water-in-oil-in-water emulsion adjuvant, it includes the component of following mass percent：
White oil is 52%, mineral oil 25%, Tween 80 1.5%, mannitol oleate are 2%, polyoxyethylene oleic acid ether-ether 10%,
Non-ionic block copolymer L180 is 8.5%, auxiliary agent 1%.
Further, a kind of ultra tiny water-in-oil-in-water emulsion adjuvant, it includes the component of following mass percent：
White oil is 60%, mineral oil 21%, Tween 80 2%, mannitol oleate are 2%, polyoxyethylene oleic acid ether-ether 6.5%,
Non-ionic block copolymer L180 is 7%, auxiliary agent 1.5%.
Further, the auxiliary agent is stabilizer propane diols and active dose of PVP PVP.
Compared with prior art, its advantage is the present invention：
The invention provides a kind of brand-new water-in-oil-in-water emulsion adjuvant formula, the sky in the domestic field can be filled up
Lack, can effectively reduce production cost, increase enterprise profit, strengthen enterprise competitiveness, there is fabulous social benefit and economy
Benefit, the industries such as biological products, daily-use chemical industry can be driven to reform production technology, especially concerning the poultry industry of national economy,
The extensive use of quality-high and inexpensive high-quality vaccine ground, due contribution is made further to improve people's living standard.
In order to the apparent understanding present invention, embodiment of the invention described in detail below.
Embodiment
Embodiment 1
A kind of ultra tiny water-in-oil-in-water emulsion adjuvant of the present invention, it includes the component of following mass percent：
White oil is 52%, mineral oil 25%, Tween 80 1.5%, mannitol oleate are 2%, polyoxyethylene oleic acid ether-ether 10%,
Non-ionic block copolymer L180 is 8.5%, auxiliary agent 1%.
Further, the auxiliary agent is stabilizer propane diols and active dose of PVP PVP.
Embodiment 2
A kind of ultra tiny water-in-oil-in-water emulsion adjuvant of the present invention, it includes the component of following mass percent：
White oil is 60%, mineral oil 21%, Tween 80 2%, mannitol oleate are 2%, polyoxyethylene oleic acid ether-ether 6.5%,
Non-ionic block copolymer L180 is 7%, auxiliary agent 1.5%.
Further, the auxiliary agent is stabilizer propane diols and active dose of PVP PVP.
Experimental comparison data：
The emulsification adjuvant of the present invention and same kind of products at abroad are subjected to multiple control experiment, data are as follows：
Table 1 is holding time experimental data
Table 2 is stability experiment data
The technological break-through of the present invention, it will be that enterprise brings good economic benefits, such product will be reduced on a large scale
The market price, production marketing price is about 7.5 ten thousand yuan/ton, in benign market competition promote relevant industries development, lifting
Relevant industries at home, the competitiveness of international market, bringing considerable economic benefit simultaneously for enterprise, it is long-range more to produce
Social benefit.
The invention is not limited in above-mentioned embodiment, if not departing from the present invention to the various changes or modifications of the present invention
Spirit and scope, if these changes and modification belong within the scope of the claim and equivalent technologies of the present invention, then this hair
It is bright to be also intended to comprising these changes and modification.
Claims (4)
1. a kind of ultra tiny water-in-oil-in-water emulsion adjuvant, it is characterised in that include the component of following mass percent：White oil
For 50%~68%, mineral oil be 21%~29%, Tween 80 is 1.5%~2.5%, mannitol oleate be 2%~
2.5%th, polyoxyethylene oleic acid ether-ether 3%~11%, non-ionic block copolymer L180 be 2.5%~9%, auxiliary agent 1%~
2.5%.
2. a kind of ultra tiny water-in-oil-in-water emulsion adjuvant according to claim 1, it is characterised in that include following quality
The component of percentage：White oil is 52%, mineral oil 25%, Tween 80 1.5%, mannitol oleate are 2%, polyoxyethylene
Oleic acid ether-ether 10%, non-ionic block copolymer L180 are 8.5%, auxiliary agent 1%.
3. a kind of ultra tiny water-in-oil-in-water emulsion adjuvant according to claim 1, it is characterised in that include following quality
The component of percentage：White oil is 60%, mineral oil 21%, Tween 80 2%, mannitol oleate are 2%, polyoxyethylene oil
Sour ether-ether 6.5%, non-ionic block copolymer L180 are 7%, auxiliary agent 1.5%.
4. according to a kind of any ultra tiny water-in-oil-in-water emulsion adjuvant of claims 1 to 3, it is characterised in that：It is described to help
Agent is stabilizer propane diols and active dose of PVP PVP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610827188.6A CN107812185A (en) | 2016-09-14 | 2016-09-14 | A kind of ultra tiny water-in-oil-in-water emulsion adjuvant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610827188.6A CN107812185A (en) | 2016-09-14 | 2016-09-14 | A kind of ultra tiny water-in-oil-in-water emulsion adjuvant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107812185A true CN107812185A (en) | 2018-03-20 |
Family
ID=61600800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610827188.6A Pending CN107812185A (en) | 2016-09-14 | 2016-09-14 | A kind of ultra tiny water-in-oil-in-water emulsion adjuvant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107812185A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006102901A2 (en) * | 2005-03-31 | 2006-10-05 | Pharmexa A/S | Immunogenic egfr peptides comprising foreign t cell stimulating epitope |
| CN102335425A (en) * | 2011-10-25 | 2012-02-01 | 石家庄维埃温特生物技术有限公司 | Method for preparing water/oil/water (W/O/W) animal vaccine oil emulsion adjuvant |
| CN102600470A (en) * | 2012-03-29 | 2012-07-25 | 江苏省农业科学院 | Compound adjuvant, vaccine containing the same, and its preparation method |
-
2016
- 2016-09-14 CN CN201610827188.6A patent/CN107812185A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006102901A2 (en) * | 2005-03-31 | 2006-10-05 | Pharmexa A/S | Immunogenic egfr peptides comprising foreign t cell stimulating epitope |
| CN102335425A (en) * | 2011-10-25 | 2012-02-01 | 石家庄维埃温特生物技术有限公司 | Method for preparing water/oil/water (W/O/W) animal vaccine oil emulsion adjuvant |
| CN102600470A (en) * | 2012-03-29 | 2012-07-25 | 江苏省农业科学院 | Compound adjuvant, vaccine containing the same, and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 孙阿惠等: "聚氧乙烯型表面活性剂的研究进展", 《中国洗涤用品工业》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1090986C (en) | Natural surfactant with amines and ethoxylated alcohol | |
| CN102002242B (en) | Organosilicon emulsion and preparation method thereof | |
| CN103641195B (en) | A kind of silicone antifoam agent and preparation method thereof | |
| CN102439120B (en) | Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions | |
| CN103788402B (en) | A kind of carbon quantum dot/hectorite emulsion-stabilizing system and prepare the method for paraffin wax emulsions | |
| Goring-Morris et al. | A hard look at the “Levantine Aurignacian”: How real is the taxon | |
| CN103897680B (en) | A kind of oil dispersible asphalt matter disperses de-plugging agent | |
| CN1843199A (en) | Nano beta-carotene emulsion and method for making same as well as uses | |
| Capretto et al. | Preparation and characterization of polysaccharidic microbeads by a microfluidic technique: application to the encapsulation of Sertoli cells | |
| CN106243364B (en) | A kind of organic silicon modified by polyether lotion and preparation method thereof | |
| MXPA05002817A (en) | Fiber assisted emulsion system. | |
| CN107083117A (en) | Aqueous color paste and preparation method thereof | |
| CN102475092A (en) | Compounded insecticidal suspension emulsion with chlorpyrifos and spirotetramat and preparation method of compounded insecticidal suspension emulsion | |
| CN107812185A (en) | A kind of ultra tiny water-in-oil-in-water emulsion adjuvant | |
| CN102343287A (en) | Oily dispersion medium for solid powder catalyst, preparation method and application thereof | |
| CN105031978A (en) | Silyl ether mixed defoaming agent emulsion and preparation method thereof | |
| CN102471083B (en) | A composition and method for enhancing the production of crystal agglomerates from a precipitation liquor | |
| CN107236775A (en) | A kind of deer SPP1 polypeptide and application | |
| CN107047546A (en) | A kind of dispersible oil-suspending agent of Mancozeb using mineral oil as medium and preparation method thereof | |
| CN1142004C (en) | A method for extracting copper from an aqueous solution | |
| CN107029449B (en) | A kind of preparation method and applications of the compound colloidal liquid aphrons of Fe3O4 magnetic liquid | |
| CN103120160A (en) | Water-based new preparation formulation ZW of prochloraz, and processing and application thereof | |
| CN104739724A (en) | Preparation process of natural skincare hydrating micro-emulsified essence composition | |
| CN105504306B (en) | A kind of application of polyethers dissaving polymer as demulsifier | |
| Löf et al. | Rheological study of the shape transition of block copolymer− nonionic surfactant mixed micelles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20230601 Address after: Card 301-006, Office Building 301, Building 5, Block B1, No. 12 Taihe North Road, Zhaoqing City, Guangdong Province, 526000 (multiple photos for one address, only for business and office purposes) Applicant after: Guangdong Super Energy Biotechnology Co.,Ltd. Address before: 526020 Shuisonggen Village, Mugang Town, Zhaoqing City, Guangdong Province Applicant before: GUANGDONG ZHAOQING CHAONENG INDUSTRIAL CO.,LTD. |
|
| TA01 | Transfer of patent application right |