CN107805310A - High-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking and preparation method thereof - Google Patents
High-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking and preparation method thereof Download PDFInfo
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Abstract
The invention discloses high-strength conductive hydrogel being crosslinked based on polyethyleneglycol diacrylate and preparation method thereof, with 2 vinyl 4, 6 diaminourea 1, 3, 5 triazines are monomer, polyethyleneglycol diacrylate is crosslinking agent, poly- (3, 4 Ethylenedioxy Thiophenes) poly- (styrene sulfonic acid) be blend components, triggering the carbon-carbon double bond progress radical polymerization on monomer and crosslinking agent to form existing physical crosslinking by initiator also has the hydrogel network of chemical crosslinking, and make poly- (3, 4 Ethylenedioxy Thiophenes) poly- (styrene sulfonic acid) is entrained in gel network structure.Not only preparation method is simple for the hydrogel of the present invention, and with very strong stretching, compression performance, preferable electric conductivity and good biocompatibility.
Description
Technical field
The invention belongs to hydrogel direction in biological technical field, more specifically to one kind with 2- vinyl -4,6-
Diamino-1,3,5-triazines, polyethyleneglycol diacrylate and poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) institute
High-strength conductive hydrogel of preparation and preparation method thereof.
Background technology
Conductive hydrogel is a kind of functional form material for combining to form both conducting polymer and hydrogel, and it not only has
There is the soft moisture performance of hydrogel, and there is conducting function.Therefore, conductive hydrogel is in ultracapacitor, lithium battery and biology
The fields such as sensor have a wide range of applications.But conductive hydrogel is often presented weak and crisp characteristic, thus mechanical property compared with
Difference.In addition, conductive hydrogel is related to the problem of hydrogel be combined with each other with conducting polymer, so its preparation process is often
It is complex.Therefore, above mentioned problem significantly limit application of the conductive hydrogel in the fields such as biomedical and electrochemistry.
At present, high-strength conductive hydrogel mainly has composite conducting hydrogel and dual network conductive hydrogel two types.Composite conducting
Hydrogel refers to electrical-conductive nanometer material such as conductive-nano-fibers, CNT and graphene etc. being added to the network of hydrogel
Strengthen the mechanical property of conductive hydrogel in structure.Dual network conductive hydrogel refers to hydrogel being immersed in containing conductive single
In the solution of body, after reaching swelling equilibrium, trigger conductive elements to carry out oxidation polymerization, led so as to form dual network with gel-in-matrix
Electric hydrogel.Although composite conducting hydrogel and dual network conductive hydrogel can strengthen conductive hydrogel to a certain extent
Mechanical property, but the preparation method of both conductive hydrogels relatively complicated (Qu B, Li J, Xiao H, et
al.Facile preparation and characterization of sodium alginate/graphite
conductive composite hydrogel[J].Polymer Composites,2015.).In addition, led for dual network
For electric hydrogel, because most of conducting polymer is insoluble in solvent, so causing working process difficult, while also can
Cause conductive component (Kishi R, Kubota K, Miura T, et the problem of distributing inhomogeneity in gel-in-matrix
al.Mechanically tough double-network hydrogels with high electronic
conductivity[J].Journal of Materials Chemistry C,2014,2(4):736-743.)。
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of with 2- vinyl -4,6- diaminostilbenes,
3,5- triazines, polyethyleneglycol diacrylate and poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) are that raw material is made
Standby hydrogel, the hydrogel have the performance of high intensity, preferable electric conductivity and good biocompatibility.
The purpose of the present invention is achieved by following technical proposals.
High-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking and preparation method thereof, by monomer 2- ethene
Base -4,6- diamino-1,3,5-triazines and crosslinking agent polyethyleneglycol diacrylate dissolve under the conditions of oil phase, and with it is poly- (3,
4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) uniformly mixing, initiator is added, is triggered under anoxic condition by initiator
The carbon-carbon double bond of monomer and crosslinking agent carries out radical polymerization, makes poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid)
It is entrained in gel network structure.
Wherein, the mass ratio of 2- vinyl-4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate for (1-
5)：1, preferably 2：1.
Oil phase selects dimethyl sulfoxide (DMSO).
The ratio of the quality sum and oil phase quality of monomer and crosslinking agent is (1-1.5)：5, preferably 1：5.
The addition of poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is 1%-the 10% of oil phase volume, excellent
Select 5-8%.
The dosage of the initiator is 1%-the 3% of two kinds of monomer mass sums.In actual use, can be according to initiation
Effect selection two-component initiator, two-component initiator are dibenzoyl peroxide and DMA, and each group
The quality for dividing initiator is all 1%-the 3% of monomer gross mass.If selecting thermal initiator, need first with inertia
Gas (such as nitrogen, argon gas or helium) excludes the oxygen in reaction system, to avoid its inhibition, then according to initiator
Activity and dosage, reaction system is heated on the initiation temperature of initiator used and kept for quite a long time, such as 1 is small
When more than or it is longer (such as 1-48 hours, preferably 20-40 hours), it is enough to promote initiator to produce for a long time
Raolical polymerizable persistently occurs for free radical, initiation reaction system.
Moreover, the temperature for triggering polymerization is 20-25 DEG C of room temperature, polymerization reaction time is 24-30 hours.
In preparation scheme, after the completion of reaction, the conductive water-setting for taking out preparation is immersed in deionized water, and removal is not joined
Add monomer, initiator, crosslinking agent and the solvent of reaction, and gel is reached swelling equilibrium and (such as immersion 7 days, is changed every 12h
Water, reaches swelling equilibrium).
In the inventive solutions, 2- vinyl -4,6- diamino-1,3,5-triazines is a kind of list with amino
Body, hydrogen bond action can be formed after radical polymerization between polymer chain and forms physical crosslinking, the presence of this physical crosslinking effect
The mechanical strength of gel can be improved.Polyethyleneglycol diacrylate is a kind of crosslinking agent, and chemical crosslinking can be formed after polymerization,
Therefore hydrogel possesses high-strength mechanical properties, in actual use using the crosslinking agent of different molecular weight purchased in market, or with
The polyethylene glycol of different molecular weight is synthesized, as the polyethylene glycol of number-average molecular weight 575-35000 can be with acryloyl chloride system
For the crosslinking agent with unsaturated bond is gone out, the number-average molecular weight of crosslinking agent is substantially consistent with polyethylene glycol, in number-average molecular weight
575—35000.Poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) of (doping) is that a kind of have high conductivity
Dark blue solution, and a kind of conducting polymer with high conductivity, high stability and good biocompatibility, select city
Purchase, viscosity is 120000-180000mPaS, and solid content is 1%-5% (i.e. purity), can directly and the oil dissolved with monomer
Phase solution uniformly mixes, and then is entrained in after polymerization in gel network structure, so the preparation of this conductive hydrogel
Method is simple and easy, triggers the unsaturated bond of monomer and crosslinking agent to carry out radical polymerization by initiator, it is successfully adulterated
Into gel three-dimensional network structure.Adulterate leading for poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) of different volumes
After electric hydrogel reaches swelling equilibrium in deionized water, its electrical conductivity is average up to 0.025S/m-0.065S/m, tensile strength
It is average average up to 5.5-10.5MPa up to 0.45-1.25MPa, compressive strength.
Application of the high-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking as conductive material.
Application of the high-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking as biomaterial, does not send out
Now significant cytotoxicity, such as it is used as cytoskeleton.
A kind of high-strength conductive hydrogel provided by the invention, with 2- vinyl -4,6- diamino-1,3,5-triazines and gather
Glycol diacrylate is raw material, after adulterating poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid), utilizes peroxidating
Dibenzoyl and DMA, which trigger, to be prepared.Due to the physical crosslinking of hydrogen bond formation and friendship in gel structure be present
Join dosage form into chemical crosslinking double action, this conductive hydrogel has very strong stretching and compression performance.The conductivity water
Not only preparation method is simple and easy for gel, and has preferable electric conductivity and good biocompatibility.
Brief description of the drawings
Fig. 1 is the structural representation of monomer 2- vinyl -4, the 6- diamino-1,3,5-triazines used in the present invention；
Fig. 2 is the structural representation of the crosslinking agent polyethyleneglycol diacrylate prepared in the present invention；
Fig. 3 is the hydrogen nuclear magnetic resonance spectrogram of the crosslinking agent polyethyleneglycol diacrylate prepared in the present invention；
Fig. 4 is the 2- second undoped with poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) synthesized in the present invention
Alkenyl -4,6- diamino-1,3,5-triazines/polyethyleneglycol diacrylate polymerize the hydrogel infrared spectrogram to be formed；
Fig. 5 is 2- ethene before and after doping poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) prepared by the present invention
Base -4,6- diamino-1,3,5-triazines/polyethyleneglycol diacrylate conductive hydrogel scanning electron microscope diagram；Wherein, scheme
A is undoped with state, and figure B is to adulterate poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) that volume fraction is 5%.
Embodiment
Technical scheme is further illustrated with reference to specific embodiment.In the embodiment of the present invention using medicine and
The conventional medication and equipment that instrument is commercially available or laboratory uses, polyethyleneglycol diacrylate (PEGDA) are with poly- second
Glycol (molecular weight 4000) and acryloyl chloride be raw material according to bibliography (Jinlong Zhang, Ning Wang,
Wenguang Liu,Xiaoli Zhao and William Lu.Intermolecular hydrogen bonding
strategy to fabricate mechanically strong hydrogels with high elasticity and
fatigue resistance[J].Soft Matter,2013,9:6331-6337) prepare with two unsaturated bonds
Crosslinking agent, and determined that structure as shown in Figure 3, will not be repeated here through hydrogen nuclear magnetic resonance spectrum.1H NMR spectras (proton magnetic
Resonance spectrum) it is to utilize deuterochloroform (CDCl3) deuterated reagent is used as, polyethyleneglycol diacrylate sample is dissolved in deuterated examination
In agent, 500MHz Liquid NMR spectrometer (models are utilized：Varian INOVA, VARIAN Oncology Systems's production) examined
Survey.Deuterochloroform (CDCl3) specification is as follows：No. CAS：865-49-6；Manufacturer：(agent is by French CIL：Visit power in Shanghai
Bio tech ltd)；The sale producer of deuterated reagent：Beijing Heng Sirui scientific ＆ trading Co., Ltd.s.A in Fig. 3, b, c, d, e's
Order is to turn left to mark successively from the right side：Chemical shift δ=3.5-3.6ppm (Ha ,-CH2-O-)；δ=4.32ppm (Hb,-CH2-O-
C=O)；δ=5.84ppm (Hc, CH2=)；δ=6.15ppm (Hd ,-CH=)；δ=6.4ppm (He, CH2=) ppm.From above-mentioned
It can prove that polyethyleneglycol diacrylate successfully synthesizes in analysis.
Embodiment 1 prepare undoped with 2- vinyl -4,6- diamino-1,3,5-triazines/polyethyleneglycol diacrylate
Conductive hydrogel
320mg 2- vinyl -4,6- diamino-1,3,5-triazines and 160mg polyethyleneglycol diacrylates are dissolved in
In 2400 μ L dimethyl sulfoxide (DMSO).Then 7.2mg dibenzoyl peroxides are added and make its dissolving, finally add 7.2 μ L N,
Accelerine.Mixed liquor is injected in closed mould, maintain 24h to ensure fully to trigger polymerization.Then turn on mould
Gel is taken out, immersion in deionized water, reaches swelling equilibrium and (such as immersion 7 days, changes a water every 12h, reach molten
Swollen balance), resulting preparation undoped with 2- vinyl -4,6- diamino-1,3,5-triazines/polyethyleneglycol diacrylate
Conductive hydrogel, it is designated as PVDT-PEGDA/PEDOT/PSS-0.
Utilize FTIS (english name：Attenuated total reflection Fourier
It is transform infrared spectroscopy, Americanized) to undoped with hydrogel characterize, sample test is
It is powdered, as shown in Figure 4.The mass ratio of 2- vinyl -4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate
For 2:1.It is located at 3330cm in figure-1And 3200cm-1The absworption peak at place is 2- vinyl -4,6- diamino-1,3,5-triazines respectively
In-NH- symmetrical stretching vibration and asymmetric stretching vibration, positioned at 1648cm-1The absworption peak at place is C=N stretching vibration, position
In 1540cm-1The absworption peak at place is C-N stretching vibration, positioned at 2870cm-1The absworption peak at place is the flexible of-CH- in crosslinking agent
Vibration, positioned at 1100cm-1The absworption peak at place is the stretching vibration of C-O-C in crosslinking agent.Monomer and friendship can be drawn according to spectrogram
Joining agent, there occurs radical polymerization.
Embodiment 2 prepares doped 2- vinyl -4,6- diamino-1,3,5-triazines/polyethyleneglycol diacrylate
Conductive hydrogel
320mg 2- vinyl -4,6- diamino-1,3,5-triazines and 160mg polyethyleneglycol diacrylates are dissolved in
In 2400 μ L dimethyl sulfoxide (DMSO), 120 μ L poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is added.Then
Add 7.2mg dibenzoyl peroxides and make its dissolving, finally add 7.2 μ L DMAs.Mixed liquor is injected
In closed mould, 24h is maintained to ensure fully to trigger polymerization.Then turn on mould and take out gel, soak in deionized water,
Reach swelling equilibrium (such as immersion 7 days, change a water every 12h, reach swelling equilibrium), resulting doped 2-
Vinyl -4,6- diamino-1,3,5-triazines/polyethyleneglycol diacrylate conductive hydrogel, is designated as PVDT-PEGDA/
PEDOT/PSS-5。
2- vinyl -4,6- diamino-1,3,5-triazines is a kind of monomer with amino, can be utilized during radical polymerization
The synergy of hydrogen bond forms physical crosslinking in gel structure.Meanwhile polyethyleneglycol diacrylate after polymerisation being capable of shape
Into chemical crosslinking, the presence of both crosslinked actions significantly improves the mechanical property of gel.
Poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) CAS：155090-83-8, Poly (3,4-
Ethylenedioxythiophene)-poly (styrenesulfonate), producer is sold：Tianjin Skien Si Aopu Deco skills
Co., Ltd, purity：1.3wt% (purity：1.3wt%dispersion in H2O).Poly- (3,4- Ethylenedioxy Thiophenes)-
Poly- (styrene sulfonic acid) is a kind of navy blue solution, mass fraction 1.3%, have high conductivity and can directly and dissolved with
The oil-phase solution of monomer uniformly mixes, and triggers 2- vinyl -4,6- diamino-1,3,5-triazines and polyethylene glycol by initiator
The unsaturated bond of diacrylate carries out radical polymerization, it is successfully doped in gel three-dimensional network structure.The power of embodiment 3
Learn the test of performance
The mechanical property of two kinds of hydrogels of above-mentioned preparation is tested with the following method.Mechanics Performance Testing is in electronics ten thousand
It can carried out on testing machine (Jinan epoch Co., Ltd), the hydrogel before test reaches swelling equilibrium in deionized water.Draw
The size for stretching the sample of Mechanics Performance Testing is 20mm × 10mm, and thickness is 500 μm, rate of extension 50mm/min；Compressive Mechanical
The sample size of performance test is diameter 10mm, high 8mm cylinder, compression speed 10mm/min.The front and rear hydrogel of doping
Stretching and compressive strength can reach MPa rank.
The test of the electric conductivity of embodiment 4
Profit detects the electric conductivity of hydrogel with the following method.Electrical performance testing is in electrochemical workstation (New Zealand
PGSTAT302N types electrochemical workstation) on tested using impedance method is crosslinked, the conductive hydrogel before test is in deionization
Reach swelling equilibrium in water.The sample size of electrical performance testing is diameter 10mm, high 1mm sequin.
The test of the cytotoxicity of embodiment 5
Profit detects the cytotoxicities of different hydrogels with the following method, in order to test hydrogel applied to biomaterial can
Can property.The gel film of various different ratios is soaked into 2h in 75% alcohol makes its sterilization, then with cushioning liquid PBS (pH
=7.4) wash, then Signa Gel is put into the bottom of 48 orifice plates.L cell kind is entered to above-mentioned 48 orifice plate
In, cultivate 48 hours.Original culture medium is then replaced by the culture medium containing Thiazolyl blue (MTT), in 37 DEG C and 5% CO2
Cultivated 4 hours under environment.Finally crystallized using 300 μ L dmso solutions bluish violets, after slight concussion 15min, use 490nm
Exciting light detect that cell survival rate has reached more than 70%, do not find significant cytotoxicity, test result indicates that
Mix and be respectively provided with good biocompatibility in front and rear gel.
Embodiment 6
320mg 2- vinyl -4,6- diamino-1,3,5-triazines and 160mg polyethyleneglycol diacrylates are dissolved in
In 2400 μ L dimethyl sulfoxide (DMSO), 24 μ L poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is added.Then plus
Enter 7.2mg dibenzoyl peroxides and make its dissolving, finally add 7.2 μ L DMAs.Mixed liquor is injected close
In the mould closed, 24h is maintained to ensure fully to trigger polymerization.Then turn on mould and take out gel, immersion in deionized water, makes
It reaches swelling equilibrium (such as immersion 7 days, change a water every 12h, reach swelling equilibrium), resulting based on polyethylene glycol
The high-strength conductive hydrogel of diacrylate crosslinking, is designated as PVDT-PEGDA/PEDOT/PSS-1.
Embodiment 7
320mg 2- vinyl -4,6- diamino-1,3,5-triazines and 160mg polyethyleneglycol diacrylates are dissolved in
In 2400 μ L dimethyl sulfoxide (DMSO), 72 μ L poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is added.Then plus
Enter 7.2mg dibenzoyl peroxides and make its dissolving, finally add 7.2 μ L DMAs.Mixed liquor is injected close
In the mould closed, 24h is maintained to ensure fully to trigger polymerization.Then turn on mould and take out gel, immersion in deionized water, makes
It reaches swelling equilibrium (such as immersion 7 days, change a water every 12h, reach swelling equilibrium), resulting based on polyethylene glycol
The high-strength conductive hydrogel of diacrylate crosslinking, is designated as PVDT-PEGDA/PEDOT/PSS-3.
Embodiment 8
320mg 2- vinyl -4,6- diamino-1,3,5-triazines and 160mg polyethyleneglycol diacrylates are dissolved in
In 2400 μ L dimethyl sulfoxide (DMSO), 192 μ L poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is added.Then
Add 7.2mg dibenzoyl peroxides and make its dissolving, finally add 7.2 μ L DMAs.Mixed liquor is injected
In closed mould, 24h is maintained to ensure fully to trigger polymerization.Then turn on mould and take out gel, soak in deionized water,
Swelling equilibrium (such as immersion 7 days, change a water every 12h, reach swelling equilibrium) is reached, it is resulting based on poly- second two
The high-strength conductive hydrogel of alcohol diacrylate crosslinking, is designated as PVDT-PEGDA/PEDOT/PSS-8.
Embodiment 9
320mg 2- vinyl -4,6- diamino-1,3,5-triazines and 160mg polyethyleneglycol diacrylates are dissolved in
In 2400 μ L dimethyl sulfoxide (DMSO), 240 μ L poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is added.Then
Add 7.2mg dibenzoyl peroxides and make its dissolving, finally add 7.2 μ L DMAs.Mixed liquor is injected
In closed mould, 24h is maintained to ensure fully to trigger polymerization.Then turn on mould and take out gel, soak in deionized water,
Swelling equilibrium (such as immersion 7 days, change a water every 12h, reach swelling equilibrium) is reached, it is resulting based on poly- second two
The high-strength conductive hydrogel of alcohol diacrylate crosslinking, is designated as PVDT-PEGDA/PEDOT/PSS-10.
Gel sample is named as PVDT-PEGDA/PEDOT/PSS-X, wherein PVDT-PEGDA represent monomer 2- vinyl-
4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate form polymer, and PEDOT/PSS represents poly- (3,4- Asia second
Propylenedioxythiophene)-poly- (styrene sulfonic acid), the body of X representative doping poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acids)
Fraction.
The gel sample of preparation is scanned electron scanning micrograph such as Fig. 5 institutes that testing electronic microscope obtains
Show.It is the conductive hydrogel undoped with poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) that Fig. 5 A, which are represented, i.e. PVDT-
PEGDA/PEDOT/PSS-0.Fig. 5 B represent the volume fraction of doping poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid)
For 5% conductive hydrogel, i.e. PVDT-PEGDA/PEDOT/PSS-5.Comparison diagram 5B and Fig. 5 A, it can be verified that poly- (3,4- Asia second
Propylenedioxythiophene)-poly- (styrene sulfonic acid) is substantially doped in the network structure of hydrogel.
Following table is the various performance parameters of hydrogel sample：
Compressive strength：During measurement, gel, which is compressed to machine maximum range, can not also compress, so at using 90% strain
Stress is as intensity.
Recorded according to present invention and the preparation technology of Signa Gel is adjusted, the Signa Gel of preparation is surveyed
Examination, the property of above-described embodiment can be achieved.Exemplary description is done to the present invention above, it should explanation, do not taking off
In the case of core from the present invention, any simple deformation, modification or other skilled in the art can not spend wound
The equivalent substitution of the property made work each falls within protection scope of the present invention.
Claims (10)
1. the high-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking, it is characterised in that：By monomer 2- vinyl-
4,6- diamino-1,3,5-triazines and crosslinking agent polyethyleneglycol diacrylate dissolve under the conditions of oil phase, and with poly- (3,4- is sub-
Ethylenedioxy thiophene)-poly- (styrene sulfonic acid) uniformly mixing, initiator is added, monomer is triggered by initiator under anoxic condition
Radical polymerization is carried out with the carbon-carbon double bond of crosslinking agent, adulterates poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid)
In gel network structure；The mass ratio of 2- vinyl -4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate is
(1—5)：1, the viscosity of poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is 120000-180000mPaS, Gu
Content is 1% -5%, the addition of poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) be oil phase volume 1% -
10%.
2. the high-strength conductive hydrogel according to claim 1 based on polyethyleneglycol diacrylate crosslinking, its feature
It is：The mass ratio of 2- vinyl -4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate is 2：1；Poly- (3,4-
Ethylenedioxy Thiophene)-the addition of poly- (styrene sulfonic acid) is 5-the 8% of oil phase volume.
3. the preparation method of the high-strength conductive hydrogel based on polyethyleneglycol diacrylate crosslinking, it is characterised in that：Will be single
Body 2- vinyl -4,6- diamino-1,3,5-triazines and crosslinking agent polyethyleneglycol diacrylate dissolve under the conditions of oil phase, and
Uniformly mixed with poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid), initiator is added, by triggering under anoxic condition
Agent triggers the carbon-carbon double bond of monomer and crosslinking agent to carry out radical polymerization, makes poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene
Sulfonic acid) it is entrained in gel network structure；
The mass ratio of 2- vinyl-4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate is (1-5)：1, gather
The viscosity of (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is 120000-180000mPaS, solid content is 1%-
5%, the addition of poly- (3,4- Ethylenedioxy Thiophene)-poly- (styrene sulfonic acid) is 1%-the 10% of oil phase volume.
4. the preparation side of the high-strength conductive hydrogel according to claim 3 based on polyethyleneglycol diacrylate crosslinking
Method, it is characterised in that：The mass ratio of 2- vinyl -4,6- diamino-1,3,5-triazines and polyethyleneglycol diacrylate is 2：
1；The addition of poly- (3,4- Ethylenedioxy Thiophenes)-poly- (styrene sulfonic acid) is 5-the 8% of oil phase volume.
5. the preparation side of the high-strength conductive hydrogel according to claim 3 based on polyethyleneglycol diacrylate crosslinking
Method, it is characterised in that：Oil phase selects dimethyl sulfoxide (DMSO).
6. the preparation side of the high-strength conductive hydrogel according to claim 3 based on polyethyleneglycol diacrylate crosslinking
Method, it is characterised in that：The ratio of the quality sum and oil phase quality of monomer and crosslinking agent is (1-1.5)：5, preferably 1：5.
7. the preparation side of the high-strength conductive hydrogel according to claim 3 based on polyethyleneglycol diacrylate crosslinking
Method, it is characterised in that：The dosage of the initiator is 1%-the 3% of two kinds of monomer mass sums；Two-component initiator is selected,
The dosage of each component initiator is 3%-the 5% of two kinds of monomer mass sums.
8. the preparation side of the high-strength conductive hydrogel according to claim 3 based on polyethyleneglycol diacrylate crosslinking
Method, it is characterised in that：The temperature for triggering polymerization is 25 DEG C of room temperature, and polymerization reaction time is 24 hours.
9. the high-strength conductive hydrogel according to claim 1 based on polyethyleneglycol diacrylate crosslinking is as conductive
The application of material.
10. the high-strength conductive hydrogel according to claim 1 based on polyethyleneglycol diacrylate crosslinking is as life
The application of thing material.
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| CN111154120A (en) * | 2020-01-15 | 2020-05-15 | 西安工程大学 | Conductive hydrogel based on reactive micelle and preparation method and application thereof |
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