CN107802705A - A kind of pill medicine and preparation method for being used to treat cervical carcinoma - Google Patents

A kind of pill medicine and preparation method for being used to treat cervical carcinoma Download PDF

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Publication number
CN107802705A
CN107802705A CN201711109350.1A CN201711109350A CN107802705A CN 107802705 A CN107802705 A CN 107802705A CN 201711109350 A CN201711109350 A CN 201711109350A CN 107802705 A CN107802705 A CN 107802705A
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medicine
cervical carcinoma
acalyphae
asarum
dandelion
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孙思远
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Sichuan Yichuang Biotechnology Co Ltd
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Sichuan Yichuang Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of pill medicine for being used to treat cervical carcinoma be provided according to the understanding mechanism of Chinese traditional treatment cervical carcinoma, each component and its mass parts ratio of the medicine are as follows：150~550g of dandelion, 30~120g of Ligusticum wallichii, 20~60g of asarum, 80~180g of Cassia occidentalis, 60~120g of fructus viticis, 30~120g of spina gleditsiae, 50~120g of cynomorium songaricum, 30~160g of the seed of feather cockscomb, 50~120g of safflower, 30~70g of subprostrate sophora, 150~350g of acalyphae,herba, 100~260g of honeysuckle, 30~150g of radix glycyrrhizae；Medicine provided by the invention is a good Chinese prescription.

Description

A kind of pill medicine and preparation method for being used to treat cervical carcinoma
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of pill medicine for being used to treat cervical carcinoma, particularly supply The pill medicine and the field of preparation method that cervical cancer patient uses.
Background technology
Doctor thinks：Cervical carcinoma is most common gynecologic malignant tumor.Carcinoma in situ Gao Fa Nian Ling is 30~35 years old, infiltrating carcinoma For 45~55 years old, its morbidity in recent years had the trend of rejuvenation.Recent decades cervical cytology examination it is commonly used, make uterine neck Cancer and precancerous lesion are able to early detection and treatment, and the morbidity and mortality of cervical carcinoma have been decreased obviously.
So, just how to find a kind of Chinese medicine composition that can effectively treat cervical carcinoma, be those skilled in the art urgently Solve the problems, such as.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment cervical carcinoma, people gradually appreciate Chinese traditional treatment The advantages of cervical carcinoma, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment palace The present situation of neck cancer, the purpose of the present invention is to be to provide a kind of pill medicine for being used to treat cervical carcinoma, to solve cervical carcinoma trouble The problem of person gets well and improved the quality of living early.The medicine is using common Chinese medicine as raw material, by selecting reasonably Medicine and mass parts ratio, it can effectively treat above-mentioned cervical carcinoma one and demonstrate,prove.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is：There is provided a kind of for treating cervical carcinoma Pill medicine and preparation method, it is characterised in that each component and mass parts of the medicine are than as follows：
150~550g of dandelion, 30~120g of Ligusticum wallichii, 20~60g of asarum, 80~180g of Cassia occidentalis, 60~120g of fructus viticis, soap 30~120g, 50~120g of cynomorium songaricum, 30~160g of the seed of feather cockscomb, 50~120g of safflower, 30~70g of subprostrate sophora, acalyphae,herba are pierced in angle 150~350g, 100~260g of honeysuckle, 30~150g of radix glycyrrhizae, auxiliary material：Appropriate starch.
A kind of pill medicine and preparation method for being used to treat cervical carcinoma, it is characterised in that each component of the medicine And mass parts are than as follows：
180~480g of dandelion, 38~105g of Ligusticum wallichii, 26~52g of asarum, 90~160g of Cassia occidentalis, 70~105g of fructus viticis, soap 38~105g, 58~105g of cynomorium songaricum, 38~140g of the seed of feather cockscomb, 58~105g of safflower, 38~60g of subprostrate sophora, acalyphae,herba are pierced in angle 180~310g, 115~230g of honeysuckle, 38~130g of radix glycyrrhizae, auxiliary material：Appropriate starch.
A kind of pill medicine and preparation method for being used to treat cervical carcinoma, it is characterised in that each component of the medicine And mass parts are than as follows：
Dandelion 420g, Ligusticum wallichii 95g, asarum 48g, Cassia occidentalis 140g, fructus viticis 95g, spina gleditsiae 95g, cynomorium songaricum 95g, the seed of feather cockscomb 120g, safflower 95g, subprostrate sophora 52g, acalyphae,herba 280g, honeysuckle 200g, radix glycyrrhizae 115g, auxiliary material：Appropriate starch.
A kind of pill medicine and preparation method for being used to treat cervical carcinoma, it is characterised in that methods described includes following step Suddenly it is prepared：
A, in addition to starch, after above-mentioned raw materials Chinese medicine is picked impurity, dust and dried, it is ground into superfine end according to mass parts ratio and treats With；
B, the method for preparing Chinese kmedicine bolus agent according to tradition, after ground superfine myrrh thing and starch sieving, it is put into medicine device Middle mixing is mixed, is then prepared into water-bindered pill agent（The granularity of its water-bindered pill is：3.8mm~4.0mm）, and then dry, sealed packaging is Can.
It is a kind of to be used to treat the pill medicine and preparation method of cervical carcinoma, it is characterised in that the instructions of taking is：Will system The water pill medicine got ready is three times a day to take, and once a dose in the morning, afternoon and evening, and dosage 5g/time, warm water delivery service.It is within 30 days One course for the treatment of, take medicine 2 courses for the treatment of after, symptom substantially mitigates, colporrhagia amount reduce.Advise to renew and take 2~3 courses for the treatment of, symptom base This disappearance.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component：
Dandelion, nature and flavor：Sweet, slight bitter, tremble with fear, there is the effect of clearing heat and detoxicating, carbuncle that disappears dissipating bind, it is swollen for treatmentization heat toxin, the evil that disappears Tuberculosis, Detoxicating food-poisoning, dissipate the diseases such as stagnant gas；
Ligusticum wallichii, nature and flavor：It is acrid flavour, warm-natured, there is the effect of promoting blood circulation, promote breath and open depression, wind-expelling pain-stopping, for treating menstruation not The stagnant raw meat pain of tune, closed dysmenorrhea, the postpartum stasis of blood, abdominal mass lump, pain in chest and hypochondrium, dizziness of having a headache, wind-cold-dampness arthralgia, traumatic injury, ulcer sore Ulcer；
Asarum, nature and flavor：It is pungent, warm, there is wind-dispelling, cold dispelling, water-filling, the effect of having one's ideas straightened out, for treat air-cooled headache, nasosinusitis, dentalgia, Phlegm and retained fluid cough is inverse, arthralgia pain due to rheumatism；
Cassia occidentalis, nature and flavor：It is bitter sweet, cool, there is the effect of clearing liver, improving eyesight, Li Shui, defaecation, for treat wind-heat cute conjunctivitis, glaucoma, Night blindness, hypertension, hepatitis, cirrhotic ascites, habitual constipation；
Broomrape, nature and flavor：It is sweet, salty, warm, there is the effect of tonifying kidney and strengthening yang, relax bowel, it is cold for treating impotence due to deficiency of the kidney, waist and knee Bitterly, dry constipation of intestines；
Fructus viticis, nature and flavor：Acrid flavour, hardship, cold nature, have dispelling wind and heat from the body, head clearing the effect of, for treat affection of exogenous wind-heat, Dizzy headache, antimigraine, swelling and aching of gum, the more tears of red eye, swell pain, the interior pain of mesh eyeball, dim not clear, arthritis with fixed pain caused by dampness contraction；
Spina gleditsiae, nature and flavor：It is acrid flavour, warm-natured, there is the effect of detumescence eliminating toxic, apocenosis, desinsection, for treat ulcer from the beginning of or purulence into Do not burst, control mange leprosy outside；
Cynomorium songaricum, nature and flavor：It is sweet, warm-natured, there is the effect of kidney-replenishing, benefiting essence-blood, relax bowel, for treating the insufficiency of the kidney yang, essence The diseases such as anemia void, waist knee impotence, impotence involuntary emission, dry constipation of intestines；
The seed of feather cockscomb, nature and flavor：Hardship, it is slightly cold, there is the effect of wind-dispelling heat, clearing away the liver-fire, improving eyesight, for treating wind-heat red eye, swell pain, screen Hinder the diseases such as blindness, skin wind-heat, sore, itch；
Safflower, nature and flavor：It is flat, sweet, have it is promoting blood circulation and removing blood stasis stimulate the menstrual flow, removing pattogenic heat from the blood and toxic material from the body the effect of, for treating Amenorrhea lump in the abdomen lump in the abdomen, the postpartum stasis of blood Resistance, febrile virulent maculae, melancholy ruffian is vexed, palpitates with fear and goes mad；
Subprostrate sophora, nature and flavor：It is bitter, cold, it is poisonous, there is the effect of clearing heat and detoxicating, detumescence relieving sore-throat, pented up for treating fiery poison, throat Swelling and pain, gingivitis；
Mazus japonicus, nature and flavor：Bitter, flat, analgesic, has the effect of stomach invigorating, removing toxic substances, for treating antimigraine, indigestion, external application is controlled The diseases such as furunculosis, impetigo；
Acalyphae,herba, nature and flavor：It is bitter, pungent, cool, have cooling blood and hemostasis, eliminating stasis to subdue swelling, removing toxic substances the effect of, for treat haematemesis, bleeding from five sense organs or subcutaneous tissue, Hematochezia, postpartum blood stasis stomachache, beat the stasis of blood swell, traumatism and bleeding, carbuncle swells furunculosis, snake bite, rheumatic arthritis；
Honeysuckle, nature and flavor：It is sweet, cold, have it is clearing heat and detoxicating the effect of, for treat warm disease heating, toxic-heat and blood stasis, carbuncle swells furunculosis, Larynx numbness and multi-infection disease；
Radix glycyrrhizae, nature and flavor：It is sweet, flat, have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription the effect of, use Swollen in treatment burnout deficiency of food, the thin face Huang of flesh, palpitation, stomachache loose stool, four limbs contraction, hysteria, cough and asthma, throat Bitterly, the disease such as ulcerative carbuncle swelling and pain, infant fetal toxin and medicine, food poisoning.
Medicine of the present invention is the principle based on Chinese traditional treatment cervical carcinoma, from the pathomechanism according to cervical carcinoma and pharmacological action Think：Cervical carcinoma one is demonstrate,proved, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, is had well to above-mentioned disease Therapeutic effect.
Embodiment
A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned cervical carcinoma, the medicine prepared using the formula Thing good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific reality of the present invention The mode of applying is described in further detail：
Embodiment 1：
A kind of pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and mass parts ratio of the medicine are as follows It is shown：
Dandelion 420g, Ligusticum wallichii 95g, asarum 48g, Cassia occidentalis 140g, fructus viticis 95g, spina gleditsiae 95g, cynomorium songaricum 95g, the seed of feather cockscomb 120g, safflower 95g, subprostrate sophora 52g, acalyphae,herba 280g, honeysuckle 200g, radix glycyrrhizae 115g, auxiliary material：Appropriate starch
Embodiment 2：
A kind of pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and mass parts ratio of the medicine are as follows It is shown：
Dandelion 480g, Ligusticum wallichii 105g, asarum 52g, Cassia occidentalis 160g, fructus viticis 105g, spina gleditsiae 105g, cynomorium songaricum 105g, green grass or young crops Feather cockscomb 140g, safflower 105g, subprostrate sophora 60g, acalyphae,herba 310g, honeysuckle 230g, radix glycyrrhizae 130g, auxiliary material：Appropriate starch
Embodiment 3：
A kind of pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and mass parts ratio of the medicine are as follows It is shown：
Dandelion 550g, Ligusticum wallichii 120g, asarum 60g, Cassia occidentalis 180g, fructus viticis 120g, spina gleditsiae 120g, cynomorium songaricum 120g, green grass or young crops Feather cockscomb 160g, safflower 120g, subprostrate sophora 70g, acalyphae,herba 350g, honeysuckle 260g, radix glycyrrhizae 150g, auxiliary material：Appropriate starch
Model case
Through clinical conditions cervical cancer patient totally 1350, the age is 715 of more than 50 years old, only 635 for 50 years old with Under.Symptom disappears substantially in 1350 patients 711, effective 369, invalid 270.Total effective rate is up to 80%.

Claims (3)

  1. A kind of 1. pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and its mass parts ratio of the medicine It is as follows：
    150~550g of dandelion, 30~120g of Ligusticum wallichii, 20~60g of asarum, 80~180g of Cassia occidentalis, 60~120g of fructus viticis, soap 30~120g, 50~120g of cynomorium songaricum, 30~160g of the seed of feather cockscomb, 50~120g of safflower, 30~70g of subprostrate sophora, acalyphae,herba are pierced in angle 150~350g, 100~260g of honeysuckle, 30~150g of radix glycyrrhizae, auxiliary material：Appropriate starch.
  2. 2. the pill medicine according to claim 1 for being used to treat cervical carcinoma, it is characterised in that each group of the medicine Divide and its mass parts are than as follows：
    180~480g of dandelion, 38~105g of Ligusticum wallichii, 26~52g of asarum, 90~160g of Cassia occidentalis, 70~105g of fructus viticis, soap 38~105g, 58~105g of cynomorium songaricum, 38~140g of the seed of feather cockscomb, 58~105g of safflower, 38~60g of subprostrate sophora, acalyphae,herba are pierced in angle 180~310g, 115~230g of honeysuckle, 38~130g of radix glycyrrhizae, auxiliary material：Appropriate starch.
  3. 3. being used for according to claim 1 to 2 treats the pill medicine of cervical carcinoma, it is characterised in that the medicine it is each Individual component and its mass parts are than as follows：
    Dandelion 420g, Ligusticum wallichii 95g, asarum 48g, Cassia occidentalis 140g, fructus viticis 95g, spina gleditsiae 95g, cynomorium songaricum 95g, the seed of feather cockscomb 120g, safflower 95g, subprostrate sophora 52g, acalyphae,herba 280g, honeysuckle 200g, radix glycyrrhizae 115g, auxiliary material：Appropriate starch.
CN201711109350.1A 2017-11-11 2017-11-11 A kind of pill medicine and preparation method for being used to treat cervical carcinoma Withdrawn CN107802705A (en)

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CN201711109350.1A CN107802705A (en) 2017-11-11 2017-11-11 A kind of pill medicine and preparation method for being used to treat cervical carcinoma

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Application publication date: 20180316