CN107782843A - A kind of titer automatic gauge method in titrimetry using photoelectric measurement mode - Google Patents
A kind of titer automatic gauge method in titrimetry using photoelectric measurement mode Download PDFInfo
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- CN107782843A CN107782843A CN201610748694.6A CN201610748694A CN107782843A CN 107782843 A CN107782843 A CN 107782843A CN 201610748694 A CN201610748694 A CN 201610748694A CN 107782843 A CN107782843 A CN 107782843A
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- Prior art keywords
- titrimetry
- titration
- titer
- photoelectric sensor
- chip microcomputer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
- G01N31/162—Determining the equivalent point by means of a discontinuity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
The invention discloses a kind of titer automatic gauge method in titrimetry using photoelectric measurement mode, adds photoelectric sensor and single-chip microcomputer than traditional metering method, overall accessory is few, and use cost is relatively low.Photoelectric sensor and single-chip microcomputer and standard titration solution, sample, titration analytical reagent of titrimetry etc. contact without any, it need not clean so as to realize function free of cleaning, it it also avoid the corrosion to photoelectric sensor and single-chip microcomputer, so that photoelectric sensor and single-chip microcomputer service life length, so as to realize low failure-frequency, low-maintenance frequency.Compared to other online titrimetry instruments standard titration solution need by jigger, carry out next titrimetry again when need to clean jigger, the present invention is shorter to the Dose times of standard titration solution, so as to shorten detection cycle duration.
Description
Technical field
The present invention relates to a kind of titer metering method, titer automatic gauge method in particularly a kind of titrimetry.
Background technology
In the prior art, problem present in titrimetry：1. it is by manually to analyzing medicine in traditional titration mode
The titer of buret is observed and is recorded, efficiency is low and can not automate, influence the large-scale low-cost of titrimetry for agent
Application；2. the general metering that titer is carried out using jigger in present online titrimetry so that have suffered titrimetry
Link is more, and accessory is more, increases the duration of detection cycle, and cleaning link is more, and natural failure-frequency, maintenance maintenance frequency need to increase,
Cost is high, or even the random error factor of testing result increases；3. in present online titrimetry, match somebody with somebody sometimes in stepper motor
Above special syringe carries out imitative titration test tube and takes out medicine and drop medicine, and the side of titration data is drawn with the step number of stepper motor rotation
Method, but when deployed between it is long when occur that accuracy declines deviation, the problems such as error is big, and the totle drilling cost of above-mentioned accessory
It is very high；The rotating speed for being moved through detecting stepper motor when syringe takes out medicine and puts medicine is so as to which conversion formula obtains being put every time
Titration pharmaceutical quantities, but often drip titer when requiring very accurate in terms of the syringe needle of syringe because being related to each titration,
And it is exactly to calculate umber of pulse in fact to calculate number of steps in terms of stepper motor, when the result that umber of pulse obtains by formula is general
All it is that the decimal of two after the meeting removes, so precision has decline.It is frequent in the syringe that stepper motor drives by a period of time
A certain amount of consumption is had during motion so that on syringe the silica gel life-span of extraction medicament can wear down, can increase so as to error,
Forbidden measurement result.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of titer automatic gauge method in titrimetry, be advantageous to drop
Low measuring cost, improve measuring accuracy.
In order to solve the above-mentioned technical problem, in a kind of titrimetry using photoelectric measurement mode of the invention titer from
Dynamic metering method, comprises the following steps,
A. standard titration solution and titration analytical reagent are prepared according to examination criteria or fixed titration assay method；
B. it is utilized respectively the 3rd peristaltic pump and adds sample to titration cell, titration point is added to titration cell using the second peristaltic pump
Reagent is analysed, standard titration solution is added dropwise by titrating head to titration cell using the first peristaltic pump, until arrival titration end-point is
Only；
C. the drop number of the standard titration solution of dropwise addition is counted using photoelectric sensor, the count results are stored in monolithic
Machine；
D. the count results that step C is obtained are calculated by the plug-in of single-chip microcomputer.
In the step B, the solution in titration cell is stirred during whole titrimetry so that various analyses
Reagent and sample are fully reacted as the step of examination criteria.
The titrating head is made up of buret and titration mouth, and the photoelectricity of the photoelectric sensor drips to the direction penetrated with standard
The direction for determining solution by titrating head instillation titration cell is orthogonal.
The beneficial effects of the invention are as follows：Titer automatic gauge method in this titrimetry using photoelectric measurement mode
In add photoelectric sensor and single-chip microcomputer, overall accessory is few, and use cost is relatively low.Photoelectric sensor and single-chip microcomputer and titration point
The standard titration solution of analysis, sample, titration analytical reagent etc. are without any contact, without cleaning so as to realizing work(free of cleaning
Can, it also avoid the corrosion to photoelectric sensor and single-chip microcomputer so that photoelectric sensor and single-chip microcomputer service life length, so as to real
Existing low failure-frequency, low-maintenance frequency.Standard titration solution compared to other online titrimetry instruments is needed by metering
Cup, carry out needing to clean jigger during next titrimetry again, the Dose times of the invention to standard titration solution are more
It is short, so as to shorten detection cycle duration.
Brief description of the drawings
The present invention is further detailed explanation with reference to the accompanying drawings and detailed description.
Fig. 1 is the schematic flow sheet of the present invention；
Fig. 2 is one of titration metering structure drawing of device；
Fig. 3 is that titrating head structural diagrams are intended to；
Fig. 4 is the two of titration metering structure drawing of device.
Embodiment
Referring to figs. 1 to Fig. 4, titer automatic gauge side in a kind of titrimetry using photoelectric measurement mode of the invention
Method, comprise the following steps,
A. standard titration solution 1 and titration analytical reagent 7 are prepared according to examination criteria or fixed titration assay method；
B. it is utilized respectively the 3rd peristaltic pump 10 and adds sample 8 to titration cell 5, is added using the second peristaltic pump 9 to titration cell 5
Titrimetry reagent 7, standard titration solution 1 is added dropwise by titrating head 3 to titration cell 5 using the first peristaltic pump 2, until reaching
Untill titration end-point；
C. the drop number of the standard titration solution 1 of dropwise addition is counted using photoelectric sensor 4, the count results are stored in monolithic
Machine 6；
D. the count results that step C is obtained are calculated by the plug-in of single-chip microcomputer 6.
In this titrimetry using photoelectric measurement mode photoelectric sensor is added in titer automatic gauge method
And single-chip microcomputer, overall accessory is few, and use cost is relatively low.Photoelectric sensor and single-chip microcomputer and the standard titration solution of titrimetry,
Sample, titration analytical reagent etc., without cleaning so as to realize function free of cleaning, it also avoid to photoelectricity without any contact
The corrosion of sensor and single-chip microcomputer so that photoelectric sensor and single-chip microcomputer service life length, so as to realize low failure-frequency, low-dimensional
Protect frequency.Standard titration solution compared to other online titrimetry instruments needs by jigger, carries out next titration again
Need to clean jigger during analysis, the present invention is shorter to the Dose times of standard titration solution, so as to shorten detection week
Phase duration.
Wherein, in the step B, the solution in titration cell 5 is stirred during whole titrimetry so that each
Kind analytical reagent and sample are fully reacted as the step of examination criteria.
The titrating head 3 is made up of buret 11 and titration mouth 12, the photoelectricity of the photoelectric sensor 4 to the direction penetrated with
The direction that standard titration solution 1 instills titration cell by titrating head 3 is orthogonal.When titrating head 3, the first peristaltic pump 2, standard drop
Determine solution 1 and its condition of work it is certain on the premise of, by titrating head 3 often drip standard titration solution 1 volume be consistent.
For same standard titration solution 1, including but not limited to the buret 11 of titrating head 3 and titration mouth 12 are to influence its drop
The principal element of the standard titration solution volume gone out.Control often drop mark can be realized by configuring the titrating head 3 of different size
The volume of quasi- volumetric soiutions 1, so as to ensure that the accuracy of measurement criteria volumetric soiutions 1 is high, error is small.
First peristaltic pump 2, the second peristaltic pump 9, the 3rd peristaltic pump 10, photoelectric sensor 4 are by the list for being built-in with program
Piece machine 6 is controlled and run.Low and high level is produced to photoelectric sensor 4 when instilling titration cell 5 using standard titration solution 1,
Low and high level signal transmits into single-chip microcomputer 6 storage and metering, so as to complete the counting of the drop number of standard titration solution 1.
The preferred embodiments of the present invention are the foregoing is only, as long as realizing the skill of the object of the invention with essentially identical means
Art scheme is belonged within protection scope of the present invention.
Claims (3)
1. a kind of titer automatic gauge method in titrimetry using photoelectric measurement mode, it is characterised in that：Including following
Step,
Prepare standard titration solution according to examination criteria or fixed titration assay method（1）With titration analytical reagent（7）；
It is utilized respectively the 3rd peristaltic pump（10）To titration cell（5）Add sample（8）, utilize the second peristaltic pump（9）To titration
Pond（5）Add titrimetry reagent（7）, utilize the first peristaltic pump（2）By standard titration solution（1）By titrating head（3）To drop
Determine pond（5）It is added dropwise, untill titration end-point is reached；
Using photoelectric sensor（4）To the standard titration solution of dropwise addition（1）Drop number counted, the count results are stored in list
Piece machine（6）；
The obtained count results of step C are passed through into single-chip microcomputer（6）Plug-in calculated.
2. titer automatic gauge method in the titrimetry according to claim 1 using photoelectric measurement mode, it is special
Sign is：In the step B, to titration cell during whole titrimetry（5）Interior solution is stirred so that various points
Analysis reagent and sample are fully reacted as the step of examination criteria.
3. titer automatic gauge method in the titrimetry according to claim 2 using photoelectric measurement mode, it is special
Sign is：The titrating head（3）By buret（11）With titrating mouth（12）Composition, the photoelectric sensor（4）Photoelectricity to penetrating
Direction and standard titration solution（1）By titrating head（3）The direction for instilling titration cell is orthogonal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610748694.6A CN107782843A (en) | 2016-08-29 | 2016-08-29 | A kind of titer automatic gauge method in titrimetry using photoelectric measurement mode |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610748694.6A CN107782843A (en) | 2016-08-29 | 2016-08-29 | A kind of titer automatic gauge method in titrimetry using photoelectric measurement mode |
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| Publication Number | Publication Date |
|---|---|
| CN107782843A true CN107782843A (en) | 2018-03-09 |
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| CN201610748694.6A Pending CN107782843A (en) | 2016-08-29 | 2016-08-29 | A kind of titer automatic gauge method in titrimetry using photoelectric measurement mode |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2466656Y (en) * | 2001-02-28 | 2001-12-19 | 山东省科学院中日友好生物技术研究中心 | Non-interference photometric titration device |
| CN1344934A (en) * | 2001-10-31 | 2002-04-17 | 湖南力合科技发展有限公司 | Automatic in-situ permanganate index analyzer |
| CN1359005A (en) * | 2001-10-19 | 2002-07-17 | 湖南力合科技发展有限公司 | High-precision fully automatic photomatrix titrimetric analysis instrument |
| CN2504640Y (en) * | 2001-10-19 | 2002-08-07 | 湖南力合科技发展有限公司 | High precision, fully automatic photometric titrimetric analyzer |
| CN102507856A (en) * | 2011-10-28 | 2012-06-20 | 方原民 | Peristaltic pump type weighing titrator and titration method thereof |
| CN202939132U (en) * | 2012-12-07 | 2013-05-15 | 保定市金科汇电子有限公司 | Automatic titration device |
| CN104964972A (en) * | 2015-06-30 | 2015-10-07 | 开平市中青环保技术服务有限公司 | Method and apparatus for determining titration end point and realizing automatic titration analysis by means of vision sensor |
| CN105242002A (en) * | 2015-10-13 | 2016-01-13 | 国网山东省电力公司电力科学研究院 | System and method for automatically detecting oleic acid value |
-
2016
- 2016-08-29 CN CN201610748694.6A patent/CN107782843A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2466656Y (en) * | 2001-02-28 | 2001-12-19 | 山东省科学院中日友好生物技术研究中心 | Non-interference photometric titration device |
| CN1359005A (en) * | 2001-10-19 | 2002-07-17 | 湖南力合科技发展有限公司 | High-precision fully automatic photomatrix titrimetric analysis instrument |
| CN2504640Y (en) * | 2001-10-19 | 2002-08-07 | 湖南力合科技发展有限公司 | High precision, fully automatic photometric titrimetric analyzer |
| CN1344934A (en) * | 2001-10-31 | 2002-04-17 | 湖南力合科技发展有限公司 | Automatic in-situ permanganate index analyzer |
| CN102507856A (en) * | 2011-10-28 | 2012-06-20 | 方原民 | Peristaltic pump type weighing titrator and titration method thereof |
| CN202939132U (en) * | 2012-12-07 | 2013-05-15 | 保定市金科汇电子有限公司 | Automatic titration device |
| CN104964972A (en) * | 2015-06-30 | 2015-10-07 | 开平市中青环保技术服务有限公司 | Method and apparatus for determining titration end point and realizing automatic titration analysis by means of vision sensor |
| CN105242002A (en) * | 2015-10-13 | 2016-01-13 | 国网山东省电力公司电力科学研究院 | System and method for automatically detecting oleic acid value |
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Application publication date: 20180309 |