CN107773327A - Eye lens, intraocular lens and the packaging body comprising eye lens - Google Patents

Eye lens, intraocular lens and the packaging body comprising eye lens Download PDF

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Publication number
CN107773327A
CN107773327A CN201610731181.4A CN201610731181A CN107773327A CN 107773327 A CN107773327 A CN 107773327A CN 201610731181 A CN201610731181 A CN 201610731181A CN 107773327 A CN107773327 A CN 107773327A
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CN
China
Prior art keywords
hydrogel
eye lens
lens
aggressiveness
silicone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610731181.4A
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Chinese (zh)
Inventor
简秀纹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hongfujin Precision Industry Shenzhen Co Ltd
Hon Hai Precision Industry Co Ltd
Original Assignee
Hongfujin Precision Industry Shenzhen Co Ltd
Hon Hai Precision Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hongfujin Precision Industry Shenzhen Co Ltd, Hon Hai Precision Industry Co Ltd filed Critical Hongfujin Precision Industry Shenzhen Co Ltd
Priority to CN201610731181.4A priority Critical patent/CN107773327A/en
Publication of CN107773327A publication Critical patent/CN107773327A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1691—Packages or dispensers for intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts

Abstract

A kind of eye lens, for low discharging anthocyanidin, including matrix and the anthocyanidin that is mixed in the matrix.A kind of intraocular lens comprising anthocyanidin and a kind of packaging body for including above-mentioned eye lens are also provided.

Description

Eye lens, intraocular lens and the packaging body comprising eye lens
Technical field
The present invention relates to a kind of eye lens, intraocular lens and packaging body comprising eye lens.
Background technology
Eye lens, intraocular lens are because the features such as its is attractive in appearance, light, stable, is using relatively broad.However, ophthalmically acceptable mirror Piece, intraocular lens itch, the situation such as see red can often occur eyes after inserting intraocular because of the intrusion of germ etc..
The content of the invention
In view of this, it is necessary to a kind of eye lens comprising anthocyanidin, intraocular lens are provided, it is described to include anthocyanidin Eye lens and intraocular lens can discharge anthocyanidin so as to protect the eyes of wearer.
A kind of packaging body for including the eye lens is provided in addition, there is a need to.
A kind of eye lens, for low discharging anthocyanidin, including matrix and the anthocyanidin that is mixed in the matrix.
A kind of intraocular lens, for low discharging anthocyanidin, including matrix and the cyanine that is mixed in the matrix Element.
A kind of packaging body, including lens protection liquid and the eye lens described above that are soaked in the lens protection liquid.
Compared to prior art, the eye lens of the technical program offer, intraocular lens, the encapsulation comprising eye lens Body, anthocyanidin can low be discharged, so as to protect the eyes of wearer.
The present invention will be further illustrated in following embodiment.
Embodiment
Better embodiment of the present invention provides a kind of eye lens or intraocular lens (IOLs), for low discharging Anthocyanidin, its anthocyanidin for including matrix and being mixed in the matrix.
Wherein, the eye lens can be contact lenses, and more specifically, the eye lens are hydrogel lenses or silicon Hydrogel lenses.The eye lens are applied to odd-numbered day throwing, double weeks throw.
The anthocyanidin is Flavonoid substances, naturally occurring in many foods, has anti-oxidant, anti-inflammatory and antiviral Effect, the anthocyanidin being slowly released in eye can be that eyes supplement the nutrients, and antiphlogistic antibacterial, make eyes more healthy.This implementation In example, the anthocyanidin can be the extract of red onion, kidney bean, pomegranate or grape etc..
In the present embodiment, mass content of the anthocyanidin in the eye lens or intraocular lens is preferably 0.005% to 3%.
In the present embodiment, when the eye lens or intraocular lens correspond to hydrogel lenses or hydrogel artificial During crystalline lens, described matrix is hydrogel；When the eye lens or intraocular lens correspond to silicone hydrogel lenses or silicon water During gel intraocular lens, described matrix is silicone-hydrogel.
Specifically, when described matrix is hydrogel, described matrix is by aggressiveness before hydrogel in ultraviolet light（UV light）Photograph Penetrate down after being copolymerized and formed, the preferably time of copolyreaction is 10 minutes to 30 minutes.Aggressiveness bag before the hydrogel Include hydrophilic monomer, light trigger and crosslinking agent.The anthocyanidin aggressiveness can add before the hydrogel before being copolymerized, After aggressiveness is copolymerized before the hydrogel, the anthocyanidin is formed at the molecular gap of described matrix, so as to wear institute State in eye lens or intraocular lens, the anthocyanidin can slowly discharge.
Wherein, the hydrophilic monomer is preferably acrylic（CR'H = CRCOX）Monomer, R are H or CH3, R' is H, CH3Or alkyl（alkly）, X O, N or hydrophilic radical；The hydrophilic monomer is more preferably 2- hydroxyethyl methacrylic acids Ester（HEMA）, N-, N- DMAAs（DMA）, methacrylic acid（MAA）, NVP（NVP）, poly- second Glycol methacrylate（ PEGMA）And sulfobetaines methyl methacrylate（SBMA）In one or more；The parent Quality accounting of the aqueous monomers before the hydrogel in aggressiveness is preferably 40% to 90%.The crosslinking agent is preferably ethylene glycol two Methacrylate（EGDMA）, trimethylol-propane trimethacrylate（TMPTMA）, N, N'- di-2-ethylhexylphosphine oxides（MBAA）In One or more；Quality accounting of the crosslinking agent before the hydrogel in aggressiveness is preferably 0.1% to 5%.The initiation Agent is preferably Irgacure-1173（I1173, chemical industry standard model）；The initiator is before the hydrogel in aggressiveness Quality accounting be preferably 0.15% to 5%.
Aggressiveness also includes solvent before the hydrogel；The solvent is preferably water, ethanol or hexanol；The solvent is described Quality accounting before hydrogel in aggressiveness is preferably 10% to 49%.
When described matrix is silicone-hydrogel, described matrix is by aggressiveness before silicone-hydrogel in ultraviolet light（UV light）Irradiation under Formed after being copolymerized, the preferably time of copolyreaction is 10 minutes to 30 minutes.Aggressiveness includes before the silicone-hydrogel Hydrophilic monomer, silicon-containing monomer, light trigger and crosslinking agent.The anthocyanidin aggressiveness can occur altogether before the silicone-hydrogel Added before poly-, after aggressiveness is copolymerized before the silicone-hydrogel, the anthocyanidin is formed at the molecular gap of described matrix, from And in the eye lens or intraocular lens is worn, the anthocyanidin can slowly discharge.
Wherein, the hydrophilic monomer is preferably acrylic（CR'H = CRCOX）Monomer, R are H or CH3, R' is H, CH3Or alkyl（alkly）, X O, N or hydrophilic radical；The hydrophilic monomer is more preferably 2- hydroxyethyl methacrylic acids Ester（HEMA）, N-, N- DMAAs（DMA）, methacrylic acid（MAA）, NVP（NVP）, poly- second Glycol methacrylate（ PEGMA）And sulfobetaines methyl methacrylate（SBMA）In one or more；It is described to contain Silicon monomer preferably includes trishydroxymethylaminomethane（TRIS）And/or dimethyl silicone polymer（PDMS）；Wherein, the hydrophily Quality accounting of the total amount of monomer and the silicon-containing monomer before the silicone-hydrogel in aggressiveness is preferably 40% to 90%.The friendship It is preferably ethylene glycol dimethacrylate to join agent（EGDMA）, trimethylol-propane trimethacrylate（TMPTMA）, N, N'- di-2-ethylhexylphosphine oxides（MBAA）In one or more；Quality accounting of the crosslinking agent before the silicone-hydrogel in aggressiveness is excellent Elect 0.1% to 5% as.The initiator is preferably Irgacure-1173（I1173, chemical industry standard model）；The initiator Quality accounting before the silicone-hydrogel in aggressiveness is preferably 0.15% to 5%.
Aggressiveness also includes solvent before the silicone-hydrogel；The solvent is preferably water, ethanol or hexanol.The solvent is in institute The quality accounting stated before silicone-hydrogel in aggressiveness is preferably 10% to 49%.
The technical program also provides a kind of packaging body for including eye lens, including eyeglass box, is packaged in the eyeglass box Interior lens protection liquid, and the above-mentioned eye lens being soaked in the lens protection liquid or intraocular lens.
Preferably, anthocyanidin, quality of the anthocyanidin in the lens protection liquid are contained in the lens protection liquid Accounting is 0.005% to 5%.
Lens protection liquid main component is water and sodium chloride, usually 0.9% common salt aqueous solution.The lens protection liquid is also Other antiseptics can be included and maintain the salt, preferably of osmotic pressure, the other compositions of lens protection liquid can also include potassium chloride, Disodium hydrogen phosphate, potassium dihydrogen phosphate, boric acid and Boratex.
The present invention is specifically described below by embodiment.
Embodiment 1
The preparation method of eye lens includes：HEMA, I1173, EGDMA, ethanol and anthocyanidin are provided and are mixed uniformly, is obtained To mixed solution.The mixed solution is placed in into contact lens to make in mould and in ultraviolet light（365 rans）Lower irradiation 10 to 30 minutes, make mixture that polymerisation occur and form gel lens, the gel lens are containing anthocyanidin after aquation Eye lens.
Wherein, HEMA weight/mass percentage composition is for 79.425%, I1173 weight/mass percentage composition in the mixed solution 0.845%, EGDMA weight/mass percentage composition are 0.83%, and the weight/mass percentage composition of anthocyanidin is 0.9%, and the quality percentage of ethanol contains Measure as 18%.
Wherein, weight/mass percentage composition of the anthocyanidin in eye lens is 1.08%.
Embodiment 2
The preparation method of eye lens includes：There is provided HEMA, DMA, TRIS, PDMS, I1173, EGDMA, hexanol and anthocyanidin simultaneously It is mixed uniformly, obtains mixed solution.The mixed solution is placed in into eye lens to make in mould and in ultraviolet light（365 Ran）Lower irradiation 10 to 30 minutes, make mixture that polymerisation occur and form gel lens, take out glue eyeglass after aquation The as eye lens containing anthocyanidin.
Wherein, in the mixed solution, the weight/mass percentage composition that HEMA weight/mass percentage composition is 6.97%, DMA is 23.6%, TRIS weight/mass percentage composition are that 45.5%, PDMS weight/mass percentage composition is 0.3%, I1173 weight/mass percentage composition Weight/mass percentage composition for 1.03%, EGDMA is 0.95%, the weight/mass percentage composition of anthocyanidin is 0.5%, the quality hundred of hexanol It is 21.15% to divide content.
Wherein, weight/mass percentage composition of the anthocyanidin in eye lens is 0.64%.
Embodiment 3
Lens protection liquid includes water, sodium chloride and anthocyanidin.Quality accounting of the anthocyanidin in the lens protection liquid be 0.03%, quality accounting of the sodium chloride in the lens protection liquid is 0.9%.
Embodiment 4
Lens protection liquid includes water, anthocyanidin, sodium chloride, potassium chloride, disodium hydrogen phosphate and potassium dihydrogen phosphate.The anthocyanidin exists Quality accounting in the lens protection liquid is 0.05%, and quality accounting of the sodium chloride in the lens protection liquid is 0.8%, quality accounting of the potassium chloride in the lens protection liquid is 0.02%, and disodium hydrogen phosphate is in the lens protection liquid Quality accounting is 0.142%, and quality accounting of the potassium dihydrogen phosphate in the lens protection liquid is 0.027%.
Embodiment 5
Lens protection liquid includes water, anthocyanidin, sodium chloride, boric acid and Boratex.The anthocyanidin is in the lens protection liquid Quality accounting be 0.08%, quality accounting of the sodium chloride in the lens protection liquid be 0.65%, boric acid is in the mirror Quality accounting in piece protection liquid is 0.5%, and quality accounting of the Boratex in the lens protection liquid is 0.04%.
Embodiment 6
Embodiment 1 or embodiment 2 eye lens can be soaked in the lens protection liquid of embodiment 3, embodiment 4 or embodiment 5 In.By eye lens and lens protection liquid in eyeglass box, in PP cups or vial, sterilized after encapsulated, obtain a packaging body.
Eye lens provided in an embodiment of the present invention, intraocular lens, the packaging body comprising eye lens, can low Anthocyanidin is discharged, so as to protect the eyes of wearer.
It is understood that for the person of ordinary skill of the art, it can be conceived with the technique according to the invention and done Go out other various corresponding changes and deformation, and all these changes and deformation should all belong to the protection model of the claims in the present invention Enclose.

Claims (19)

1. a kind of eye lens, for low discharging anthocyanidin, including matrix and the anthocyanidin that is mixed in the matrix.
2. eye lens as claimed in claim 1, it is characterised in that quality of the anthocyanidin in the eye lens contains Measure as 0.005% to 3%.
3. eye lens as claimed in claim 1, it is characterised in that described matrix is hydrogel or silicone-hydrogel.
4. eye lens as claimed in claim 3, it is characterised in that described matrix is hydrogel, and described matrix is by hydrogel Preceding aggressiveness is formed after being copolymerized under the irradiation of ultraviolet light, and aggressiveness includes hydrophilic monomer before the hydrogel, light draws Send out agent and crosslinking agent；Or, described matrix is silicone-hydrogel, described matrix is issued by irradiation of the aggressiveness before silicone-hydrogel in ultraviolet light Formed after raw copolyreaction, aggressiveness includes hydrophilic monomer, silicon-containing monomer, light trigger and crosslinking agent before the silicone-hydrogel.
5. eye lens as claimed in claim 4, it is characterised in that the hydrophilic monomer is acrylic（CR'H = CRCOX）Monomer, R are H or CH3, R' is H, CH3Or alkyl（alkly）, X O, N or hydrophilic radical.
6. eye lens as claimed in claim 5, it is characterised in that the hydrophilic monomer is selected from 2- hydroxyethyl methyl propylene Acid esters（HEMA）, N-, N- DMAAs（DMA）, methacrylic acid（MAA）, NVP（NVP）, it is poly- Glycolmethacrylate（ PEGMA）And sulfobetaines methyl methacrylate（SBMA）In one or more.
7. eye lens as claimed in claim 4, it is characterised in that described matrix is hydrogel, and the hydrophilic monomer exists Quality accounting before the hydrogel in aggressiveness is 40% to 90%.
8. eye lens as claimed in claim 4, it is characterised in that the crosslinking agent is selected from ethylene glycol dimethacrylate （EGDMA）, trimethylol-propane trimethacrylate（TMPTMA）, N, N'- di-2-ethylhexylphosphine oxides（MBAA）In one or more.
9. eye lens as claimed in claim 4, it is characterised in that crosslinking agent aggressiveness or described before the hydrogel Quality accounting before silicone-hydrogel in aggressiveness is 0.1% to 5%.
10. eye lens as claimed in claim 4, it is characterised in that the initiator is Irgacure-1173；It is described to draw It is 0.15% to 5% to send out quality accounting of the agent before the hydrogel before aggressiveness or the silicone-hydrogel in aggressiveness.
11. eye lens as claimed in claim 4, it is characterised in that described matrix is silicone-hydrogel, the silicon-containing monomer choosing One or more from trishydroxymethylaminomethane, dimethyl silicone polymer.
12. eye lens as claimed in claim 4, it is characterised in that described matrix is silicone-hydrogel, the hydrophilic monomer It is 40% to 90% with the quality accounting of the total amount of the silicon-containing monomer before the silicone-hydrogel in aggressiveness.
13. eye lens as claimed in claim 4, it is characterised in that before the hydrogel before aggressiveness or the silicone-hydrogel Aggressiveness also includes solvent, and quality accounting of the solvent before the hydrogel before aggressiveness or the silicone-hydrogel in aggressiveness is 10% to 49%.
14. a kind of intraocular lens, for low discharging anthocyanidin, including matrix and the cyanine that is mixed in the matrix Element.
15. intraocular lens as claimed in claim 14, it is characterised in that the anthocyanidin is in the intraocular lens Mass content is 0.005% to 3%.
16. intraocular lens as claimed in claim 14, it is characterised in that described matrix is hydrogel or silicone-hydrogel.
17. a kind of packaging body, including lens protection liquid and be soaked in the lens protection liquid as described in claim 1-13 Eye lens.
18. eye lens as claimed in claim 17, it is characterised in that contain anthocyanidin in the lens protection liquid.
19. eye lens as claimed in claim 18, it is characterised in that matter of the anthocyanidin in the lens protection liquid Amount accounting is 0.005%-5%.
CN201610731181.4A 2016-08-26 2016-08-26 Eye lens, intraocular lens and the packaging body comprising eye lens Pending CN107773327A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610731181.4A CN107773327A (en) 2016-08-26 2016-08-26 Eye lens, intraocular lens and the packaging body comprising eye lens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610731181.4A CN107773327A (en) 2016-08-26 2016-08-26 Eye lens, intraocular lens and the packaging body comprising eye lens

Publications (1)

Publication Number Publication Date
CN107773327A true CN107773327A (en) 2018-03-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610731181.4A Pending CN107773327A (en) 2016-08-26 2016-08-26 Eye lens, intraocular lens and the packaging body comprising eye lens

Country Status (1)

Country Link
CN (1) CN107773327A (en)

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Application publication date: 20180309