CN107753104A - Compatible water-cooled microwave ablation needle of a kind of magnetic and preparation method thereof - Google Patents

Compatible water-cooled microwave ablation needle of a kind of magnetic and preparation method thereof Download PDF

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Publication number
CN107753104A
CN107753104A CN201711249494.7A CN201711249494A CN107753104A CN 107753104 A CN107753104 A CN 107753104A CN 201711249494 A CN201711249494 A CN 201711249494A CN 107753104 A CN107753104 A CN 107753104A
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CN
China
Prior art keywords
coaxial cable
notch
needle
nonmagnetic
becket
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Pending
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CN201711249494.7A
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Chinese (zh)
Inventor
黄晓燕
周玉福
葛梦柯
邱本胜
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University of Science and Technology of China USTC
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University of Science and Technology of China USTC
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Application filed by University of Science and Technology of China USTC filed Critical University of Science and Technology of China USTC
Priority to CN201711249494.7A priority Critical patent/CN107753104A/en
Publication of CN107753104A publication Critical patent/CN107753104A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00059Material properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00589Coagulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00964Features of probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1869Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument interstitially inserted into the body, e.g. needles

Abstract

The invention provides a kind of microwave melt needle, part used in microwave melt needle provided by the invention selects non-magnetic material, the microwave tumour ablation art that can be used safely under Magnetic resonance imaging guiding, it is to human body without ionising radiation, image resolution ratio is high, arbitrary orientation is imaged, and can effectively improve the success rate of operation.Microwave melt needle uses the design that coaxial cable multi-notch is combined with nonmagnetic becket, eliminates the shank tail waste heat problem in existing microwave melt needle heating process, ablation gained region is approximately one spherical, meets most tumors shape;It is equally possible that according to the shape of different tumours, the interval between notch quantity and the width and notch of notch is adjusted, different ablation shapes is obtained, ablation efficiency can be effectively improved in the case where not damaging normal structure.

Description

Compatible water-cooled microwave ablation needle of a kind of magnetic and preparation method thereof
Technical field
The invention belongs to technical field of medical instruments, and in particular to a kind of compatible water-cooled microwave ablation needle of magnetic and its preparation Method.
Background technology
At present, the microwave tumour ablation art of minimally invasive intervention is widely used in clinic.Microwave tumour ablation art is that microwave disappears Melt pin and be transferred to microwave melt needle front end in image-guided lower insertion tissue focus, the microwave energy as caused by microwave ablation instrument Lasting transmitting, makes Junctional tissue heat production, and a spherical thermal field is formed in several minutes, and central temperature is higher than 100 DEG C, edge temperature Degree is more than 60 DEG C so that tissue coagulation, dehydration necrosis.Microwave tumour ablation art efficiency high, wound are small, depth of interaction to tissue It is controllable with scope.
Most of microwave tumour ablation art be CT or ultrasound guidance by microwave melt needle percutaneous puncture into tumour Heart district domain, but the image guiding of the minimally invasive intervention as main flow, CT and ultrasound have some limitations.Ultrasonoscopy resolution ratio Not high, it is in terms of tumor boundaries are judged by a definite limitation;CT radiates big to doctor and patient.Comparatively speaking, nuclear magnetic resonance Imaging technique does not injure to human body, and it has, and higher accuracy, image resolution ratio are high, soft tissue contrast is high, any more Orientation imaging, imaging parameters enrich.
However, existing available microwave melt needle can not be made by being limited in terms of material technology under magnetic resonance environment With limiting the development of microwave tumour ablation art.What is more important, existing available microwave melt needle ablation gained region is all For a strip spheroid-like, and most of tumours are all close to spheroidal, in order to completely inactivate tumor tissues, it is necessary to add The scope melted greatly, so inherently damages human normal tissue, and unnecessary injury is caused to human body.
The content of the invention
In view of this, the technical problem to be solved in the present invention be to provide a kind of compatible water-cooled microwave ablation needle of magnetic and its Preparation method, the compatible water-cooled microwave ablation needle of magnetic provided by the invention can be used safely in the microwave under Magnetic resonance imaging guiding Tumour ablation art, ablation areas is adjustable, and ablation efficiency can be effectively improved in the case where not damaging normal structure, and needle tubing is integrated Construction, it is safe.
The invention provides a kind of compatible water-cooled microwave ablation needle of magnetic, including:
Zirconium oxide needle tubing (1), the zirconium oxide needle tubing include needle point and hollow needle body;
Coaxial cable (2), the coaxial cable (2) include inner wire, dielectric and outer conductor, the coaxial cable (2) inner wire of front end is connected with outer conductor and is arranged on inside the hollow needle body, and the surface of the coaxial cable is certainly The front end of the coaxial cable along its axis direction offer 8~10 it is being communicated with the dielectric, equidistantly distributed Annular notches;
It is arranged inside the hollow needle body, and is sheathed on the nonmagnetic metal on the outer conductor surface of coaxial cable (2) Ring (3), the nonmagnetic becket (3) be disposed furthest from the side of the notch of coaxial cable (2) front end and be close to it is described most Notch away from coaxial cable (2) front end;In the hollow needle body, the nonmagnetic becket (3) to needle point end The space at end is confined space;
It is opened in the water inlet and delivery port of hollow needle body end;
The radio frequency (RF) coaxial connector (6) being connected with the tail end of the coaxial cable (2).
Preferably, the width of each notch is identical, and the width of the notch is 0.1~0.5mm, the adjacent notch At intervals of 0.5~1mm, the depth of the notch is the thickness of the outer conductor.
Preferably, coaxial cable (2) front end and described between the notch of the coaxial cable (2) front end Interval is more than the distance between adjacent notch.
Preferably, the coaxial cable is magnetic compatibility coaxial cable, and the inner wire and outer conductor of the coaxial cable are nothing Magnetic metal.
Preferably, the internal diameter of the nonmagnetic becket (3) is more than the coaxial cable (2) external diameter, the nonmagnetic gold The external diameter for belonging to ring (3) is less than the internal diameter of the hollow needle body, and the width of the nonmagnetic becket (3) is an EWL ± 5mm, the calculation formula of the EWL are as follows:
Wherein, c is the velocity of wave in vacuum, and f is used microwave frequency, ∈rIt is normal for the relative dielectric of ripple transmission medium Number.
Preferably, the water inlet is connected with water inlet pipe (4), and the delivery port is connected with outlet pipe (5), the water inlet pipe (4) it is non-magnetic material, the outlet pipe (5) is non-magnetic material, and the radio frequency (RF) coaxial connector (6) is nonmagnetic conduction material Material.
Preferably, the external diameter of the coaxial cable is 0.8mm-2.2mm, and the length of the coaxial cable is 135mm- 215mm。
Preferably, the needle point and the integrated construction of hollow needle body, the needle point is solid cone, described The height of cone is 3mm-6mm, and the length of the hollow needle body is 109mm-192mm, and the external diameter of the hollow needle body is 1.6mm-3.0mm, the internal diameter of the hollow needle body is 1.0mm-2.6mm.
Preferably, in addition to it is arranged at the needle handle (7) of the zirconium oxide needle tubing tail end.
Present invention also offers a kind of preparation method of the compatible water-cooled microwave ablation needle of above-mentioned magnetic, comprise the following steps:
A) inner wire of coaxial cable (2) front end is connected with outer conductor welding;
B) on the surface of coaxial cable (2), from the position of the coaxial cable (2) front end along its axis direction cutting 8~ 10 annular notches communicated with the dielectric, equidistantly distributed;
C nonmagnetic becket (3)) is inserted in the coaxial cable surface, and it is with adhesive that nonmagnetic becket (3) is solid Due to the notch farthest away from coaxial cable (2) front end side and be close to the notch farthest away from coaxial cable (2) front end;
D) in nonmagnetic becket (3) the surface coating a layer of adhesive, and by the first half of the coaxial cable (2) Divide in the hollow needle body of the insertion zirconium oxide needle tubing (1) after being contacted to the front end of the coaxial cable (2) with the end of needle point, Bonding is dried, it is confined space to make the nonmagnetic becket (3) to the space of the tip end;
E) water inlet pipe (4) water inlet is connected, outlet pipe (5) is connected with delivery port;
F) by the tail end adhesive seal of the zirconium oxide needle tubing (1);
G) radio frequency (RF) coaxial connector (6) is connected with the tail end welding of the coaxial cable (2), and needle handle (7) is installed In the zirconium oxide needle tubing tail end.
Compared with prior art, the compatible water-cooled microwave ablation needle of a kind of magnetic, it is characterised in that including:Zirconium oxide needle tubing (1), the zirconium oxide needle tubing includes needle point and hollow needle body;Coaxial cable (2), the coaxial cable (2) include interior lead Body, dielectric and outer conductor, the inner wire of the front end of the coaxial cable (2) are connected with outer conductor and are arranged on described hollow Needle body inside, the surface of the coaxial cable along its axis direction offer 8~10 it is being communicated with the dielectric, etc. The annular notches of spacing distribution;It is arranged inside the hollow needle body, and be sheathed on the outer conductor surface of coaxial cable (2) Nonmagnetic becket (3), the nonmagnetic becket (3) are disposed furthest from the side of the notch of coaxial cable (2) front end simultaneously It is close to the notch farthest away from coaxial cable (2) front end;In the hollow needle body, the nonmagnetic becket (3) is extremely The space of the tip end is confined space;It is opened in the water inlet and delivery port of hollow needle body end;With the coaxial electrical The connected radio frequency (RF) coaxial connector (6) of the tail end of cable (2).Part used in microwave melt needle provided by the invention is selected without magnetic material Material, the microwave tumour ablation art that can be used safely under Magnetic resonance imaging guiding, it is to human body without ionising radiation, image resolution ratio Height, arbitrary orientation are imaged, and can effectively improve the success rate of operation.Microwave melt needle using coaxial cable multi-notch with it is nonmagnetic The design that becket is combined, eliminate the shank tail waste heat problem in existing microwave melt needle heating process, ablation gained area Domain is approximately one spherical, meets most tumors shape;It is equally possible that according to the shape of different tumours, notch number is adjusted Interval between amount and the width and notch of notch, obtains different ablation shapes, in the case where not damaging normal structure Ablation efficiency can be effectively improved.In addition, the zirconium oxide needle tubing of microwave melt needle provided by the invention using integration, improve with Past microwave melt needle need to weld in addition or the phenomenon of bonded needle, avoids syringe needle easy to fall off in surgical procedure, human body is caused Unnecessary injury;In addition, zirconia material is easy to puncture to human body non-hazardous and firm.
Brief description of the drawings
Fig. 1 is the structural representation of the compatible water-cooled microwave ablation needle of magnetic provided by the invention.
Embodiment
The invention provides a kind of compatible water-cooled microwave ablation needle of magnetic, including:
Zirconium oxide needle tubing (1), the zirconium oxide needle tubing include needle point and hollow needle body;
Coaxial cable (2), the coaxial cable (2) include inner wire, dielectric and outer conductor, the coaxial cable (2) inner wire of front end is connected with outer conductor and is arranged on inside the hollow needle body, and the surface of the coaxial cable is certainly The front end of the coaxial cable along its axis direction offer 8~10 it is being communicated with the dielectric, equidistantly distributed Annular notches;
It is arranged inside the hollow needle body, and is sheathed on the nonmagnetic metal on the outer conductor surface of coaxial cable (2) Ring (3), the nonmagnetic becket (3) be disposed furthest from the side of the notch of coaxial cable (2) front end and be close to it is described most Notch away from coaxial cable (2) front end;In the hollow needle body, the nonmagnetic becket (3) to needle point end The space at end is confined space;
It is opened in the water inlet and delivery port of hollow needle body end;
The radio frequency (RF) coaxial connector (6) being connected with the tail end of the coaxial cable (2).
Referring to Fig. 1, Fig. 1 is the structural representation of the compatible water-cooled microwave ablation needle of magnetic provided by the invention.In Fig. 1,1 is Zirconium oxide needle tubing, 2 be coaxial cable, and 2-1 is notch, and 3 be nonmagnetic becket, and 4 be water inlet pipe, and 5 be outlet pipe, and 6 be radio frequency Coaxial connector, 7 be needle handle.
The compatible water-cooled microwave ablation needle of magnetic provided by the invention includes zirconium oxide needle tubing (1), the zirconium oxide needle tubing bag Include needle point and hollow needle body.
In the present invention, the needle point is the integrated design with hollow needle body, so as to avoid syringe needle in surgical procedure It is easy to fall off, unnecessary injury is caused to human body.Wherein, needle point is preferably solid cone, is easy to puncture in surgical procedure;Institute The length for stating hollow needle body is 109mm-192mm, preferably 120~160mm;The external diameter of the hollow needle body is 1.6mm- 3.0mm, preferably 2.0~2.5mm;The internal diameter of the hollow needle body is 1.0mm-2.6mm, preferably 1.5~2.0mm.It is hard Zirconium oxide needle tubing (1) be easy to puncture in surgical procedure, and hollow needle body can provide passage for water circulation.
The compatible water-cooled microwave ablation needle of magnetic provided by the invention also includes coaxial cable (2), coaxial cable (2) bag Inner wire, dielectric and outer conductor are included, the inner wire of the front end of the coaxial cable (2) is connected and is arranged on outer conductor Inside the hollow needle body, the surface of the coaxial cable offers 8 from the front end of the coaxial cable along its axis direction ~10 annular notches communicated with the dielectric, equidistantly distributed;
In the present invention, the coaxial cable is magnetic compatibility, and the inner wire is nonmagnetic metal, preferably silver-plated copper Line, the outer conductor are nonmagnetic metal, preferably plate the seamless annealing copper tube of ternary alloy three-partalloy.
The first half of the coaxial cable (2) is arranged inside the hollow needle body, after the coaxial cable (2) Half part is extended to outside needle body.
The external diameter of the coaxial cable is 0.8mm-2.2mm, preferably 1.2~1.8mm;The length of the coaxial cable is 135mm-215mm, preferably 150~180mm.
The inner wire of coaxial cable (2) front end is connected with outer conductor, and is touched with the joining distal ends of the needle point.
The surface of the coaxial cable from the front end of the coaxial cable along its axis direction offer 8~10 with it is described Annular notches that dielectric communicates, equidistantly distributed.
Coaxial cable (2) front end and the interval between the notch of the coaxial cable (2) front end are big In the distance between adjacent notch.
In the present invention, the number of the notch is 8~10, and the width of each notch is identical, and the width of the notch is 0.1~0.5mm, the adjacent notch at intervals of 0.5~1mm, the depth of the notch is the thickness of the outer conductor.
Wherein, the control of the width of institute's otch and notch so that microwave energy is maximumlly outwards radiate, in group Knit middle formation thermal field, ablated tumor;Interval between adjacent notch so that energy maximization concentrates on notch periphery;This hair The bright control by notch number, width of rebate and adjacent notch interval, ablation areas of different shapes can be obtained.
The compatible water-cooled microwave ablation needle of magnetic provided by the invention also includes being arranged in the hollow needle body and being arranged Nonmagnetic becket (3) in the outer conductor surface of coaxial cable (2), the nonmagnetic becket (3) are disposed furthest from together Simultaneously it is close to the notch farthest away from coaxial cable (2) front end in the side of the notch of shaft cable (2) front end.Wherein, it is described farthest Side from the notch of coaxial cable (2) front end is close to the side of the end of coaxial cable.
The internal diameter of the nonmagnetic becket (3) is more than the coaxial cable (2) external diameter, the nonmagnetic becket (3) External diameter be less than the hollow needle body internal diameter, the width of the nonmagnetic becket (3) is an EWL ± 5mm, The calculation formula of the EWL is as follows:
Wherein, λ is EWL, and c is the velocity of wave in vacuum, and f is used microwave frequency, ∈rFor ripple transmission medium Relative dielectric constant.
In the present invention, the nonmagnetic becket (3) is selected from without magnetic conductance electric metal, preferably copper, silver or aluminium, more preferably For copper.
Added nonmagnetic becket (3) can eliminate needle tubing tail waste heat problem in ablation procedure so that ablation areas connects Nearly elliposoidal or spheroidal, meet tumor shape.
The compatible water-cooled microwave ablation needle of magnetic provided by the invention also include being opened in the water inlet of hollow needle body end with Delivery port.
In certain specific embodiments of the invention, the water inlet is connected with water inlet pipe (4), and the delivery port is with going out Water pipe (5) is connected, and the water inlet pipe (4) is non-magnetic material, and the outlet pipe (5) is non-magnetic material, the RF coaxial Connector (6) is nonmagnetic conductive material.
In certain specific embodiments of the invention, the water inlet pipe (4) and outlet pipe (5) intercalation are to described hollow It is oppositely arranged inside needle body and with the coaxial cable (2) for axle center, the part of the water inlet pipe (4) and outlet pipe (5) is in institute State in hollow needle body, remainder extends to the external side of the hollow needle.
The water inlet of the water inlet pipe (4) is connected with the first plastic flexible pipe, the convenient pin to the water-cooled microwave ablation needle Water is passed through in pipe, the delivery port of the outlet pipe (5) is connected with the second plastic flexible pipe, will be delivered to pin for the water for cooling down needle body In vitro, water circulation effectively reduces the temperature of needle wall in ablation procedure, avoids calcination skin.
The water inlet pipe (4) is non-magnetic material, preferably titanium alloy tube, earthenware or copper pipe;The outlet pipe (5) is Non-magnetic material, preferably titanium alloy tube, earthenware or copper pipe.
In the hollow needle body, end to the space of the nonmagnetic becket (3) of the hollow needle body is Confined space.
The compatible water-cooled microwave ablation needle of magnetic provided by the invention also includes what is be connected with the tail end of the coaxial cable (2) Radio frequency (RF) coaxial connector (6).
The radio frequency (RF) coaxial connector (6) is nonmagnetic conductive material, and the radio frequency (RF) coaxial connector (6) is silver-plated by aluminum Material manufacture.
The compatible water-cooled microwave ablation needle of magnetic provided by the invention also includes the pin for being arranged at the zirconium oxide needle tubing tail end Handle (7).
Present invention also offers a kind of preparation method of the compatible water-cooled microwave ablation needle of above-mentioned magnetic, comprise the following steps:
A) inner wire of coaxial cable (2) front end is connected with outer conductor welding;Specifically, by coaxial cable (2) front end Outer conductor peeled off with intermediate insulating layer, the welding of inner wire and outer conductor is connected.
B) on the surface of coaxial cable (2), from the position of the coaxial cable (2) front end along its axis direction cutting 8~ 10 annular notches communicated with the dielectric, equidistantly distributed;
In the present invention, the method for the cutting is preferably line cutting technology.
C nonmagnetic becket (3)) is inserted in the coaxial cable surface, and it is with adhesive that nonmagnetic becket (3) is solid Due to the notch farthest away from coaxial cable (2) front end side and be close to the notch farthest away from coaxial cable (2) front end.Institute It is preferably high temperature resistant waterproof silicone adhesive to state binding agent.
D) on nonmagnetic becket (3) surface and lower surface coating a layer of adhesive, and by the coaxial cable (2) First half insert in the hollow needle body of the zirconium oxide needle tubing (1) to the front end of the coaxial cable (2) and the end of needle point After end in contact, bonding is dried, it is confined space to make the nonmagnetic becket (3) to the space of the tip end, i.e., Inside hollow needle body, the space sealing between the nonmagnetic becket (3) to the needle point, all notches are all in this In confined space, the latter half of the coaxial cable (2) extends to the external side of the hollow needle;Described adhesive is preferably resistance to High temperature waterproof silicone adhesive.
E) water inlet pipe (4) water inlet is connected, outlet pipe (5) is connected with delivery port, by water inlet pipe (4) and outlet pipe (5) water inlet respectively with the hollow needle body end of the zirconium oxide needle tubing (1) is connected with delivery port, and with the coaxial cable (2) it is oppositely arranged for axle center, the part of the water inlet pipe (4) and outlet pipe (5) is in the hollow needle body, remainder extension To the external side of the hollow needle;
The water inlet of the water inlet pipe (4) is connected with the first plastic flexible pipe, the convenient pin to the water-cooled microwave ablation needle Water is passed through in pipe, the delivery port of the outlet pipe (5) is connected with the second plastic flexible pipe, will be delivered to pin for the water for cooling down needle body In vitro, water circulation effectively reduces the temperature of needle wall in ablation procedure, avoids calcination skin.By the water inlet pipe and outlet pipe with Plastic flexible pipe is connected, described connected using UV glue bonding.
F) by the tail end adhesive seal of the zirconium oxide needle tubing (1), it is preferred to use UV glue is sealed;
G) radio frequency (RF) coaxial connector (6) is connected with the tail end welding of the coaxial cable (2), and needle handle (7) is installed In the zirconium oxide needle tubing tail end.
Part used in microwave melt needle provided by the invention selects non-magnetic material, can be used safely in Magnetic resonance imaging and draw Microwave tumour ablation art under leading, to human body without ionising radiation, image resolution ratio is high, arbitrary orientation imaging, can effectively carry for it The success rate of height operation.Microwave melt needle uses the design that coaxial cable multi-notch is combined with nonmagnetic becket, eliminates existing There is the shank tail waste heat problem in microwave melt needle heating process, ablation gained region is approximately one spherical, meets majority Tumor shape;It is equally possible that according to the shape of different tumours, adjust between notch quantity and the width and notch of notch Interval, obtain different ablation shapes, ablation efficiency can be effectively improved in the case where not damaging normal structure.In addition, this Using the zirconium oxide needle tubing of integration, improving conventional microwave melt needle need to weld or glue in addition the microwave melt needle that invention provides The phenomenon of syringe needle is connect, avoids syringe needle easy to fall off in surgical procedure, unnecessary injury is caused to human body;In addition, zirconium oxide material Material is easy to puncture to human body non-hazardous and firm.
For a further understanding of the present invention, with reference to the embodiment water cooling microwave ablation compatible to magnetic provided by the invention Pin and preparation method thereof is illustrated, and protection scope of the present invention is not limited by the following examples.
Embodiment 1
A kind of compatible water-cooled microwave ablation needle of magnetic is present embodiments provided, including:Zirconium oxide needle tubing 1, coaxial cable 2, Copper ring 3, water inlet pipe 4, outlet pipe 5, radio frequency (RF) coaxial connector 6 and needle handle 7.
Specifically include:
Zirconium oxide needle tubing (1), the zirconium oxide needle tubing include needle point and hollow needle body;
Coaxial cable (2), the coaxial cable (2) include inner wire, dielectric and outer conductor, the coaxial cable (2) inner wire of front end is connected with outer conductor and is arranged on inside the hollow needle body, and the surface of the coaxial cable is certainly The front end of the coaxial cable along its axis direction offer 8~10 it is being communicated with the dielectric, equidistantly distributed Annular notches;
It is arranged inside the hollow needle body, and is sheathed on the nonmagnetic metal on the outer conductor surface of coaxial cable (2) Ring (3), the nonmagnetic becket (3) be disposed furthest from the side of the notch of coaxial cable (2) front end and be close to it is described most Notch away from coaxial cable (2) front end;In the hollow needle body, the nonmagnetic becket (3) to needle point end The space at end is confined space;
It is opened in the water inlet and delivery port of hollow needle body end;
The radio frequency (RF) coaxial connector (6) being connected with the tail end of the coaxial cable (2).
It is arranged at the needle handle (7) of the zirconium oxide needle tubing tail end.
The front end inner wire of the coaxial cable 2 connects with outer conductor welding, and the outer conductor of coaxial cable 2 uses wire cutting skill Art cuts 10 notch 2-1, and copper ring 3 is inserted in the outside of last notch on the surface of coaxial cable 2 (i.e. close to coaxial cable end The side at end), the both ends of copper ring 3 are be bonded with coaxial cable 2 using high temperature resistant waterproof silicone adhesive, then resistance in one layer of copper ring surface smear High temperature waterproof silicone adhesive, then coaxial cable 2 is inserted in zirconium oxide needle tubing 1 to front end and bonding is dried, water inlet pipe 4 is with going out Water pipe 5 is aoxidizing with being connected respectively with water inlet and delivery port, and at the tail end of copper ring 3 place being inserted into zirconium oxide needle tubing 1 The tail end of zirconium needle tubing 1 smearing UV glue is simultaneously fast by zirconium oxide needle tubing 1 and coaxial cable 2, water inlet pipe 4, outlet pipe 5 with ultra violet lamp Speed is adhesively fixed and water shutoff, radio frequency (RF) coaxial connector 6 are welded on the tail end of coaxial cable 2.
The external diameter of zirconium oxide needle tubing 1 is 2.2mm, and total length 170mm, front end is solid cone, is highly 4mm, Rear end is hollow needle tube, and internal diameter is 1.9mm, length 166mm more than the external diameter of copper ring 3.
The coaxial cable 2 is non-magnetic, external diameter 1.19mm, length 196mm, the front end inner wire of coaxial cable 2 Connected with outer conductor welding, cut 10 notches successively since front end, the width of each notch is 0.2mm, notch and notch The distance between be 1mm, first notch is from being 4.5mm with a distance from the front end of coaxial cable 2.
The external diameter of copper ring 3 is 1.5mm, internal diameter 1.25mm, length 18mm, is inserted in the last of the surface of coaxial cable 2 Behind one notch, and it is adhesively fixed using high temperature resistant waterproof silicone adhesive.
The water inlet pipe 4, outlet pipe 5 are manufactured by titanium alloy material, external diameter 0.5mm, internal diameter 0.3mm, water inlet pipe 4 Length is 150mm, and the length of outlet pipe 5 is 100mm, and water inlet pipe 4, outlet pipe 5 are glued in tail end using UV glue and plastic flexible pipe Connect, so as to be changed with the water pipe of the outside of needle handle 7.
The radio frequency (RF) coaxial connector 6 is the silver-plated joint of aluminum, the tail end of coaxial cable 2 is welded in, with microwave generator It is connected.
The needle handle 7 is manufactured by plastic material, water inlet pipe 4, outlet pipe 5, the radio frequency that will extend into outside hollow needle body Coaxial connector 6 envelopes.
The water-cooled microwave ablation needle can use under magnetic resonance, use finite element analysis software, emulation ablation gained area Domain is approximately the shape that a radius is 34mm spheroidals.
Embodiment 2
A kind of compatible water-cooled microwave ablation needle of magnetic is present embodiments provided, including:Zirconium oxide needle tubing 1, coaxial cable 2, Copper ring 3, water inlet pipe 4, outlet pipe 5, radio frequency (RF) coaxial connector 6 and needle handle 7.
Specifically include:
Zirconium oxide needle tubing (1), the zirconium oxide needle tubing include needle point and hollow needle body;
Coaxial cable (2), the coaxial cable (2) include inner wire, dielectric and outer conductor, the coaxial cable (2) inner wire of front end is connected with outer conductor and is arranged on inside the hollow needle body, and the surface of the coaxial cable is certainly The front end of the coaxial cable along its axis direction offer 8~10 it is being communicated with the dielectric, equidistantly distributed Annular notches;
It is arranged inside the hollow needle body, and is sheathed on the nonmagnetic metal on the outer conductor surface of coaxial cable (2) Ring (3), the nonmagnetic becket (3) be disposed furthest from the side of the notch of coaxial cable (2) front end and be close to it is described most Notch away from coaxial cable (2) front end;In the hollow needle body, the nonmagnetic becket (3) to needle point end The space at end is confined space;
It is opened in the water inlet and delivery port of hollow needle body end;
The radio frequency (RF) coaxial connector (6) being connected with the tail end of the coaxial cable (2).
It is arranged at the needle handle (7) of the zirconium oxide needle tubing tail end.
The front end inner wire of the coaxial cable 2 connects with outer conductor welding, and the outer conductor of coaxial cable 2 uses wire cutting skill Art cuts 10 notch 2-1, and copper ring 3 is inserted in the outside of last notch on the surface of coaxial cable 2 (i.e. close to coaxial cable end The side at end), the both ends of copper ring 3 are be bonded with coaxial cable 2 using high temperature resistant waterproof silicone adhesive, then resistance in one layer of copper ring surface smear High temperature waterproof silicone adhesive, then coaxial cable 2 is inserted in zirconium oxide needle tubing 1 to front end and bonding is dried, water inlet pipe 4 is with going out Water pipe 5 is aoxidizing with being connected respectively with water inlet and delivery port, and at the tail end of copper ring 3 place being inserted into zirconium oxide needle tubing 1 The tail of zirconium needle tubing 1
End smearing UV glue is simultaneously fast by zirconium oxide needle tubing 1 and coaxial cable 2, water inlet pipe 4, outlet pipe 5 with ultra violet lamp Speed is adhesively fixed and water shutoff, radio frequency (RF) coaxial connector 6 are welded on the tail end of coaxial cable 2.
The external diameter of zirconium oxide needle tubing 1 is 2.2mm, and total length 170mm, front end is filled arrows shape, and length is 4mm, rear end are hollow needle tube, and internal diameter is 1.9mm, length 166mm more than the external diameter of copper ring 3.
The coaxial cable 2 is non-magnetic, a diameter of 1.19mm, length 196mm, the front end inner wire of coaxial cable 2 Connect with outer conductor welding, cuts 8 notches successively since front end, the width of each notch is 0.5mm, notch and notch it Between distance be 0.5mm, first notch is from being 4.5mm with a distance from the front end of coaxial cable 2.
The external diameter of copper ring 3 is 1.5mm, internal diameter 1.25mm, length 10mm, is inserted in the last of the surface of coaxial cable 2 Behind one notch, and it is adhesively fixed using high temperature resistant waterproof silicone adhesive.
The water inlet pipe 4, outlet pipe 5 are manufactured by titanium alloy material, external diameter 0.5mm, internal diameter 0.3mm, water inlet pipe 4 Length is 148mm, and the length of outlet pipe 5 is 98mm, and water inlet pipe 4, outlet pipe 5 are glued in tail end using UV glue and plastic flexible pipe Connect, so as to be changed with the water pipe of the outside of needle handle 7.
The radio frequency (RF) coaxial connector 6 is the silver-plated joint of aluminum, the tail end of coaxial cable 2 is welded in, with microwave generator It is connected.
The needle handle 7 is manufactured by plastic material, and water inlet pipe 4, outlet pipe 5, radio frequency (RF) coaxial connector 6 are enveloped.
The water-cooled microwave ablation needle can use under magnetic resonance, use finite element analysis software, emulation ablation gained area Domain is approximately a spheroid shape, short axle 34mm, major axis 42mm.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (10)

  1. A kind of 1. compatible water-cooled microwave ablation needle of magnetic, it is characterised in that including:
    Zirconium oxide needle tubing (1), the zirconium oxide needle tubing include needle point and hollow needle body;
    Coaxial cable (2), the coaxial cable (2) include inner wire, dielectric and outer conductor, the coaxial cable (2) The inner wire of front end is connected with outer conductor and is arranged on inside the hollow needle body, and the surface of the coaxial cable is from described same The front end of shaft cable offers 8~10 annular grooves communicated with the dielectric, equidistantly distributed along its axis direction Mouthful;
    It is arranged inside the hollow needle body, and is sheathed on the nonmagnetic becket on the outer conductor surface of coaxial cable (2) (3), the nonmagnetic becket (3) is disposed furthest from the side of the notch of coaxial cable (2) front end and is close to described farthest From the notch of coaxial cable (2) front end;In the hollow needle body, the nonmagnetic becket (3) to the tip end Space be confined space;
    It is opened in the water inlet and delivery port of hollow needle body end;
    The radio frequency (RF) coaxial connector (6) being connected with the tail end of the coaxial cable (2).
  2. 2. water-cooled microwave ablation needle according to claim 1, it is characterised in that the width of each notch is identical, described The width of notch is 0.1~0.5 mm, and the adjacent notch is to be led outside described at intervals of 0.5~1mm, the depth of the notch The thickness of body.
  3. 3. water-cooled microwave ablation needle according to claim 1, it is characterised in that coaxial cable (2) front end with it is described Interval between the notch of the coaxial cable (2) front end is more than the distance between adjacent notch.
  4. 4. water-cooled microwave ablation needle according to claim 1, it is characterised in that the coaxial cable is magnetic compatibility coaxial electrical Cable, the inner wire and outer conductor of the coaxial cable are nonmagnetic metal.
  5. 5. water-cooled microwave ablation needle according to claim 1, it is characterised in that the internal diameter of the nonmagnetic becket (3) More than the coaxial cable (2) external diameter, the external diameter of the nonmagnetic becket (3) is less than the internal diameter of the hollow needle body, institute The width for stating nonmagnetic becket (3) is an EWL ± 5mm, and the calculation formula of the EWL is as follows:
    <mrow> <mi>&amp;lambda;</mi> <mo>=</mo> <mfrac> <mi>c</mi> <mrow> <mi>f</mi> <msqrt> <msub> <mo>&amp;Element;</mo> <mi>r</mi> </msub> </msqrt> </mrow> </mfrac> </mrow>
    Wherein, c is the velocity of wave in vacuum, and f is used microwave frequency, ∈rFor the relative dielectric constant of ripple transmission medium.
  6. 6. water-cooled microwave ablation needle according to claim 1, it is characterised in that the water inlet is connected with water inlet pipe (4), The delivery port is connected with outlet pipe (5), and the water inlet pipe (4) is non-magnetic material, and the outlet pipe (5) is nonmagnetic material Material, the radio frequency (RF) coaxial connector (6) is nonmagnetic conductive material.
  7. 7. water-cooled microwave ablation needle according to claim 1, it is characterised in that the external diameter of the coaxial cable is 0.8mm- 2.2mm, the length of the coaxial cable is 135mm-215mm.
  8. 8. water-cooled microwave ablation needle according to claim 1, it is characterised in that the needle point is with the hollow needle body Integrated structure, the needle point are solid cone, and the height of the cone is 3mm-6mm, the length of the hollow needle body Spend for 109mm-192mm, the external diameter of the hollow needle body is 1.6mm-3.0mm, and the internal diameter of the hollow needle body is 1.0mm- 2.6mm。
  9. 9. water-cooled microwave ablation needle according to claim 1, it is characterised in that also include being arranged at the zirconium oxide needle tubing The needle handle (7) of tail end.
  10. 10. a kind of preparation method of the compatible water-cooled microwave ablation needle of magnetic as claimed in any one of claims 1 to 9 wherein, it is special Sign is, comprises the following steps:
    A) inner wire of coaxial cable (2) front end is connected with outer conductor welding;
    B) on the surface of coaxial cable (2), 8~10 are cut from the position of the coaxial cable (2) front end along its axis direction Annular notches communicated with the dielectric, equidistantly distributed;
    C nonmagnetic becket (3)) is inserted in the coaxial cable surface, and is fixed on nonmagnetic becket (3) with adhesive Farthest away from the side of the notch of coaxial cable (2) front end and it is close to the notch farthest away from coaxial cable (2) front end;
    D) in nonmagnetic becket (3) the surface coating a layer of adhesive, and the first half of the coaxial cable (2) is inserted Enter after being contacted in the hollow needle body of the zirconium oxide needle tubing (1) to the front end of the coaxial cable (2) with the end of needle point, carry out Bonding is dried, it is confined space to make the nonmagnetic becket (3) to the space of the tip end;
    E) water inlet pipe (4) water inlet is connected, outlet pipe (5) is connected with delivery port;
    F) by the tail end adhesive seal of the zirconium oxide needle tubing (1);
    G) radio frequency (RF) coaxial connector (6) is connected with the tail end welding of the coaxial cable (2), and needle handle (7) is installed on institute State zirconium oxide needle tubing tail end.
CN201711249494.7A 2017-12-01 2017-12-01 Compatible water-cooled microwave ablation needle of a kind of magnetic and preparation method thereof Pending CN107753104A (en)

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CN108784830A (en) * 2018-07-11 2018-11-13 安徽大中润科技有限公司 microwave needle
CN109330680A (en) * 2018-12-04 2019-02-15 安徽大中润科技有限公司 Magnetic compatible dipole microwave ablation needle
CN109330681A (en) * 2018-12-06 2019-02-15 安徽大中润科技有限公司 Magnetic compatible water-cooling microwave ablation needle and manufacturing method thereof
CN113827784A (en) * 2021-09-27 2021-12-24 东劢医疗科技(苏州)有限公司 Medical nano heat-non-conductive composite material and preparation method and application thereof
CN114469329A (en) * 2018-05-25 2022-05-13 南通融锋医疗科技有限公司 Microwave ablation antenna for GGO treatment

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CN206138201U (en) * 2016-07-26 2017-05-03 安徽硕金医疗设备有限公司 Compatible microwave ablation needle of magnetic resonance
CN208784913U (en) * 2017-12-01 2019-04-26 中国科学技术大学 A kind of water-cooled microwave ablation needle that magnetic is compatible

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CN103717166A (en) * 2011-04-08 2014-04-09 柯惠有限合伙公司 Flexible microwave catheters for natural or artificial lumens
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CN204600678U (en) * 2015-01-21 2015-09-02 王华明 A kind of needle head structure of double window type microwave melt needle
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114469329A (en) * 2018-05-25 2022-05-13 南通融锋医疗科技有限公司 Microwave ablation antenna for GGO treatment
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CN109330681A (en) * 2018-12-06 2019-02-15 安徽大中润科技有限公司 Magnetic compatible water-cooling microwave ablation needle and manufacturing method thereof
CN113827784A (en) * 2021-09-27 2021-12-24 东劢医疗科技(苏州)有限公司 Medical nano heat-non-conductive composite material and preparation method and application thereof

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