CN107737393A - A kind of fogging runner for powder vapor inhalator - Google Patents
A kind of fogging runner for powder vapor inhalator Download PDFInfo
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- CN107737393A CN107737393A CN201710946859.5A CN201710946859A CN107737393A CN 107737393 A CN107737393 A CN 107737393A CN 201710946859 A CN201710946859 A CN 201710946859A CN 107737393 A CN107737393 A CN 107737393A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
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Abstract
A kind of fogging runner for powder vapor inhalator, category administration device field.Fogging runner is formed by entering powder passage, tangential rotating drum and bending dispensing passage；At least two tangential admission passages are provided with tangential rotating drum side wall；Upward powder formulation outlet is provided among tangential rotating drum top；Enter powder passage to coincide with the lateral cross section where tangential rotating drum or parallel；The air-flow entered in powder passage or each tangential admission passage, by it is coplanar laterally cut in a manner of enter in described hollow cavity；Enter powder passage or the gas passage of each tangential admission passage and the gas rotating passage of tangential rotating drum is tangent, formed in tangential rotating drum and rotate horizontally air-flow.Because tangential rotating drum is in horizontality in actual use, holdup time of the powder aggregate in cavity is rotated is added, more collision opportunity can be provided between powder aggregate and rotating drum cavity wall；Be advantageous to further disperseing for powder agglomerated particle.
Description
Technical field
The invention belongs to the instrument field for inputting medium in human body, more particularly to a kind of it is used for the dust cloud of prescribed dose
The inhalation-type drug administration apparatus of patient lungs is sent into agent with respiratory air flow direct oral cavity.
Background technology
Powder spray, refer to micronized medicine or with carrier with capsule, vesicle or multiple dose reservoir type, using special powder
Mist agent suction apparatus or doser (or be suction type medicator, the past is also referred to as powder inhaler or dry powder is given
Medicine device), atomization medicine is actively sucked by patient to the dosage form of lung.
Inhalation powder spray makes drug powder enter respiratory system by the autonomous respiration of patient, has and is easy to carry, cost
It is low, the characteristics of stability is strong.
In recent years, the application of inhalation powder spray is extended to polypeptide protein from traditional lung local disease curative
Class, antibiotic, the Formulations for systemic administration of bio-pharmaceutical and medicine for cardiovascular system.Particularly some large biological molecules inhale through drug powder
Enter-pulmonary administration after can realize comparatively ideal bioavilability.
Powder vapor inhalator is the core of powder spray exploitation, and its quality designed directly influences powder spray pulmonary deposition
The height of efficiency.
For powder vapor inhalator (Dry Powder Inhaler, DPI), most crucial part is exactly its dispersed structure,
The degree of cooperation of the structure and preparation, the effect of directly influencing DPI products.DPI of the exploitation with stronger dispersibility is filled
Put, be the key link for developing such product.
The principle that general DPI products disperse to powder formulation aggregate is disperseed for air-flow shearing, collision is scattered etc..In difference
DPI devices in play having nothing in common with each other for leading peptizaiton.
Authorized announcement date is September in 2007 27, and Authorization Notice No. is in CN 100337699C Chinese invention patent,
Disclose a kind of " the powder form dispersal device and method that are used on dry powder inhaler ", it is scattered on its dry powder inhaler
Part includes：One substantially cylindrical air circulation chamber 3, at least two air feed channels (2,9), this two passes
At the substantially relative sidepiece of cylindrical wall 5 by with the cylindrical wall it is tangent in a manner of extend in chamber 3, and be suitable for
An annular air flow patterns are formed in the chamber, the two air ducts (2,9) are provided with multiple different entrances
Or the same entrance being separated is shared respectively, region is fed with the dosage measurement or dosage of one crosscutting inhalator of formation
Passage 2, so as to which the powder of dose is dragged in circulation chamber 3 by the air for flowing through the passage, and another logical
Road is used as the bypass passageways 9 for leading to circulation chamber 3, and the passage is well-suited for Particle Acceleration and the shape in the chamber 3
Into a more symmetrical flow problem.
Using the DPI products of technical scheme described in the patent, a profile substantially cylinder for its whole DPI product,
In the bottom of cylinder, it is provided with " doser " for storing powder formulation, during actual use, cylindric DPI is produced
Product are horizontal, and user is by the suction nozzle air-breathing being pointed at the top of cylinder, then the powder formulation stored in " doser ", warp
Passage 2 is dragged into circulation chamber 3, by discharge-channel 19 and mouthpiece cylinder 13, into the oral cavity of user.
According to the related text content in the patent specification accompanying drawing and specification, in the technical scheme to preparation powder
Last aggregate carries out scattered dispersion principle and is analyzed as follows：Powder formulation particle is from powder passage 2 is entered along the track of gas streamline
Tangential to enter circulation chamber 3, under the shearing force of air-flow, little particle is directly sucked out with air-flow by outlet 19, big
Grain due to poor and effect by centrifugal force is stronger with fluidity, can and the cavity wall 22 of circulation chamber 3 collide, from
And be advantageous to little particle and separated from carrier, finally all it is sucked out by outlet 19.
From its Figure of description, powder passage 2 and rotary gas streamline place in circulation chamber 3 are entered in the technical scheme
The plane cross section of chamber (actually rotate) be perpendicular.
In other words, it is that powder formulation enters powder passage 2 from below circulation chamber the characteristics of above-mentioned isolating construction
In (cross section that this enters powder passage and circulation chamber 3 is perpendicular), with the direction tangent with circulation chamber 3, at during use
In the circulation chamber 3 that vertical state is set, by the shear action of swirling eddy, to decompose, depolymerization (being commonly called as being atomized, similarly hereinafter) system
Agent powder；Centrifugal action when particle moves in a circle is taken full advantage of in its operation principle.
But this technical scheme is disadvantageous in that, its peptizaiton depends on merely centrifugation of the air-flow to micro mist aggregate
The collision of the aggregate for acting on and thereby resulting in and rotating drum wall, the gravity of aggregate can disturb the effect of this dispersion process.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of fogging runner for powder vapor inhalator.Its
On the basis of the structurally and functionally mechanism of existing disengagement chamber, by the tactic pattern and function mould that redesign disperseing runner
Block, change the mutual alignment relation into powder passage and rotating separation chamber, extend bulky grain powder formulation particle in split cavity
In holdup time；By rotating separation chamber export set bending dispensing passage, using make bulky grain powder formulation particle with
The cavity wall 26S Proteasome Structure and Function pattern that (or multiple) collides again, can more thoroughly disperse/depolymerization/atomization preparation powder
End, further better ensure that separation/atomizing effect of powder spray micro mist aggregate subparticle.
The technical scheme is that：A kind of fogging runner for powder vapor inhalator, described system are provided
Agent atomization runner is arranged on powder storage/between administration unit and suction nozzle, it is characterized in that：
Described fogging runner at least enters powder passage, tangential rotating drum and bending dispensing passage group by what is penetrated successively
Into；
Described tangential rotating drum is the hollow cavity for the flat disc structure that a height is less than its diameter；
In the side wall of tangential rotating drum；It is provided with least two tangential admission passages；A tangential admission therein leads to
Road also serves as feeding opening simultaneously；Described at least two tangential admission passages, which are centrosymmetric to be distributed in, forms tangential rotating drum envelope
On round circumference；
Among the top of the tangential rotating drum, upward powder formulation outlet is provided with；
The central axis of powder formulation outlet and the plane where tangential rotating drum horizontal center line are perpendicular；
The outlet of powder storage/administration unit is connected with entering the top of powder passage, enters the end of powder passage and tangential rotation
The feeding opening connection of chamber；The powder formulation outlet of tangential rotating drum is connected with the head end of bending dispensing passage, bending dispensing passage
End be connected with suction nozzle；
Lateral cross section where the lateral cross section entered where powder passage horizontal center line, with tangential rotating drum horizontal center line
Coincide or parallel.
The air-flow entered in powder passage or each tangential admission passage, by it is coplanar laterally cut in a manner of enter it is described in
In cavity body；
Enter powder passage or the gas passage of each tangential admission passage and the gas rotating passage of tangential rotating drum is tangent,
Swirling eddy is formed in tangential rotating drum.
Described bending dispensing passage is used to carry out again the powder spray powder aggregate after the separation of tangential rotating drum
Secondary collision, and will be by the rotating separation and powder spray powder of collision rift is delivered at suction nozzle again, for user's suction；
When user's actual use powder vapor inhalator carries out suction medicine, the cross-section of the tangential rotating drum is in water
Level state；Or the cross section of the tangential rotating drum and the angle of horizontal plane are less than 45 degree.
Specifically, described bending dispensing passage is by the first Connectivity Section, bending segment and the second Connectivity Section structure that are sequentially communicated
Into；The head end of first Connectivity Section forms the head end of bending dispensing passage, connection corresponding with the outlet of tangential rotating drum；It is described
The connection corresponding with the head end of bending segment of the port of export of first Connectivity Section, the entrance point of the end of the bending segment and the second Connectivity Section
Corresponding connection；The port of export connection corresponding with suction nozzle of second Connectivity Section；Described the first Connectivity Section, bending segment and the second company
Logical section, forms a dogleg passage structure similar to zigzag or reverse-s shape shape.
Further, the horizontal center line of first Connectivity Section is parallel with the horizontal center line of tangential rotating drum；The
The horizontal center line of the horizontal center line of two Connectivity Sections and tangential rotating drum coincides；Where first Connectivity Section horizontal center line
Plane and the plane parallel where the second Connectivity Section horizontal center line.
Fogging runner in the technical program, by three portions of component in runner lower member, runner and runner upper member
Part forms.
Wherein described runner lower member forms the bottom into powder passage and tangential rotating drum；Component structure in described runner
Into the side wall and top for entering powder passage and tangential rotating drum, and the bottom of bending dispensing passage and side wall；On described runner
Component forms the top of bending dispensing passage.
Specifically, the cross section of the hollow cavity inwall is a polygonized structure, the feeding opening and each tangential
Inlet channel, it is successively set on respectively at the odd number apex end of polygonized structure；Or the feeding opening and each tangential admission
Passage, it is successively set on respectively at the even numbers apex end of polygonized structure.
Further, symmetric polygonal or regular polygon centered on described polygonized structure.
Tangential rotating drum in the technical program, described tangential rotating drum, by rotating horizontally scattered mode of operation
To solve the aggregate of powder formulation, the Action of Gravity Field of centrifugal action and particle in itself when being moved in a circle using particle, make
Bulky grain powder formulation aggregate in the presence of the two power in the increased retention of tangential rotating drum, so as to more thorough
Ground pharmaceutical dispersions powder aggregate, and through the powder formulation outlet output positioned at tangential rotating drum top to bending dispensing passage.
Further, in described bending dispensing passage, powder formulation aggregate is due to poor with fluidity, meeting and bending
The cavity wall of dispensing passage collides again, so as to realize the further separation or atomization of powder formulation aggregate.
The technical program is provided with least one bypass air inlet at least side of the outlet section of the bending dispensing passage
Mouthful, to adjust the overall suction resistance of powder vapor inhalator.
Specifically, the cross-sectional area of one bypass air inlet, or the cross-sectional area sum of two bypass air inlets, it is small
In or equal to bending dispensing passage port of export cross-sectional area 30%.
Compared with the prior art, it is an advantage of the invention that：
1. because in actual use, tangential rotating drum is in horizontality, big powder aggregate in this rotating drum by
In the effect of horizontal centrifugal power, can occur more to collide with the cavity wall of tangential rotating drum；And because the powder after scattered is upward
Rise, export discharge by the powder formulation on tangential rotating drum top, then due to the effect of gravity, increase powder aggregate and exist
The rotation holdup time in tangential rotating drum cavity, more collisions can be provided between powder aggregate and the cavity wall of rotating drum
Chance；
2. being in same plane due to entering powder passage and tangential rotating drum, and enter the gas passage of powder passage and tangential rotation
The gas rotating passage of chamber is tangent, and more preferably air-flow shear action can be formed in tangential rotating drum, is advantageous to powder aggregate
Particle further disperses；
3. by the side at the port of export or suction nozzle of the second Connectivity Section, bypass air inlet is set, and it is transversal to adjust its
The size of area, the overall suction resistance of powder vapor inhalator can be conveniently adjusted, improve the use feeling of user.
Brief description of the drawings
Fig. 1 is the outline structural diagram of the fogging runner of this patent；
Fig. 2 is the contour structures top view of the fogging runner of this patent；
Fig. 3 is the present invention looks up structural representation of the fogging runner of this patent and tangential rotating drum；
Fig. 4 is cross section structure diagrams of the Fig. 2 along E-E ' hatchings；
Fig. 5 is the diagrammatic side-view cross-sectional structural representation of the fogging runner of this patent and tangential rotating drum；
Fig. 6 is the structural representation of the art of this patent scheme bending dispensing passage；
Fig. 7 be in the art of this patent scheme tangential rotating drum to the dispersion principle schematic diagram of powder formulation aggregate；
Fig. 8 be in the art of this patent scheme bending dispensing passage to the dispersion principle schematic diagram of powder formulation aggregate；
Fig. 9 is the bypass inlet structure schematic diagram of this patent；
Figure 10 is the schematic diagram that air inlet and the ratio between cross-sectional area at suction nozzle are bypassed in the art of this patent scheme；
Figure 11 is that the deposition in vitro of medicine 1 tests profiles versus's schematic diagram (n=3)；
Figure 12 is that the deposition in vitro of medicine 2 tests profiles versus's schematic diagram (n=3).
In figure, 51 be primary air inlet, and 51-2 is medicine feeding hole, and 52 be into powder passage；53 be tangential rotating drum；53-1 is to cut
To rotating drum cavity wall, 53-2 is tangential admission passage, and 53-3 is feeding opening, and 54 go out for the powder formulation of tangential rotating drum
Mouthful, 55 be bending dispensing passage；55-1 is the first Connectivity Section, 55-2 is bending segment, and the Connectivity Sections of 55-3 second, 56 be bypass air inlet
Mouthful；57 be the outlet of fogging runner；
B is runner lower member；C is component in runner；D is runner upper member；F1 is gas streamline；F2 is powder formulation group
The particle of polymers；F3 is the trajectory of particle；
I is the cross-sectional area of fogging runner exit；II is the cross-sectional area of bypass air inlet.
Embodiment
The present invention will be further described with reference to the accompanying drawings and examples.
For Fig. 1 into Fig. 6, technical scheme provides a kind of fogging stream for powder vapor inhalator
Road, described fogging runner are arranged on powder storage/between administration unit and suction nozzle, and its inventive point is：
Described fogging runner at least is disperseed to lead to by enter powder passage 52, tangential rotating drum 53 and the bending that penetrate successively
Road 55 forms；
Described tangential rotating drum is the hollow cavity for the flat disc structure that a height is less than its diameter；
On the side wall 53-1 of tangential rotating drum；At least two tangential admission passage 53-2 are (with three tangential admissions in Fig. 3
Exemplified by passage, at its simplest, only two tangential admission passages need to be set, you can rotation is formed in tangential rotating drum
Air-flow), a tangential admission passage therein also serves as feeding opening 53-3 simultaneously；Described each bar tangential admission passage is in center pair
Claim to be distributed on the circumference for forming tangential rotating drum envelope circle.
Among the top of the tangential rotating drum, upward powder formulation outlet 54 is provided with.
The central axis of powder formulation outlet and the plane where tangential rotating drum horizontal center line are perpendicular.
The outlet of powder storage/administration unit is connected with entering the top of powder passage, enters the end of powder passage and tangential rotation
The feeding opening connection of chamber；The powder formulation outlet of tangential rotating drum is connected with the head end of bending dispensing passage, bending dispensing passage
End be connected with suction nozzle；
Lateral cross section where the lateral cross section entered where powder passage horizontal center line, with tangential rotating drum horizontal center line
Coincide or parallel.
The air-flow entered in powder passage or each tangential admission passage, by it is coplanar laterally cut in a manner of enter it is described in
In cavity body.
Enter powder passage or the gas passage of each tangential admission passage and the gas rotating passage of tangential rotating drum is tangent,
Formed in tangential rotating drum and rotate horizontally air-flow.
In Fig. 4, the fogging runner in technical solution of the present invention, by component in runner lower member B, runner in structure
Tri- part compositions of C and runner upper member D.
Understand as shown in Figure 5, runner lower member B constitutes the bottom into powder passage 52 and tangential rotating drum 53；
Medicine feeding hole 51-2 is offered on runner lower member B, the just outlet with powder storage/administration unit (is in figure
Show) it is correspondingly arranged.
Entering the head end of powder passage 52, be provided with primary air inlet 51, when user is against suction nozzle air-breathing, gas enters from master
Gas port 51 is inhaled into, by medicine feeding hole 51-2, by the powder formulation particle of pre-set dosage in powder storage/administration unit
Bring into powder passage 52.
Component C forms the side wall and top into powder passage and tangential rotating drum in runner, and bending dispensing passage 55
Bottom and at least a portion side wall；Runner upper member D forms the top of bending dispensing passage and a part of side wall.
Tri- parts of component C and runner upper member D in foregoing runner lower member B, runner, can use injection molding process
Make, then three parts fasten successively, that is, form a complete fogging flow channel component.
In actual fabrication and fogging this component of runner of production, making listed herein is not limited solely to
Technique, the technological means that can be possessed completely according to manufacturer, manufactured using other moulding process described fogging
Runner, it will not be described in detail herein.
It will be appreciated from fig. 6 that foregoing bending dispensing passage by the first Connectivity Section 55-1, the bending segment 55-2 that are sequentially communicated and
Second Connectivity Section 55-3 is formed.Wherein, the head end of the first Connectivity Section forms the head end of bending dispensing passage, with tangential rotating drum
54 corresponding connection of powder formulation outlet；The port of export connection corresponding with the head end of bending segment of first Connectivity Section, the bending
The end connection corresponding with the entrance point of the second Connectivity Section of section；The port of export of second Connectivity Section and suction nozzle (not shown)
Corresponding connection.
It is apparent that the first Connectivity Section, bending segment and the second Connectivity Section, composition one is similar to zigzag or reverse-s shape shape
Dogleg passage structure.
It is apparent that as shown in Figure 5, the horizontal center line of the first Connectivity Section is equal with the horizontal center line of tangential rotating drum
OK；The horizontal center line of the horizontal center line of second Connectivity Section and tangential rotating drum coincides；First Connectivity Section horizontal center line
The plane at place and the plane parallel where the second Connectivity Section horizontal center line.
The tangential rotating drum in the technical program, it is that a height is less than its diameter shown in Fig. 3 and Fig. 7
The hollow cavity of flat disc structure.
The cross section of the hollow cavity inwall is a polygonized structure, the feeding opening 53-3 and each tangential admission
Passage 53-2, be successively set on respectively at the odd number apex end of polygonized structure (if using end points where feeding opening as No. 1 end points,
Then two tangential admission passages are separately positioned on No. 3 and No. 5 end points, and this actually means that feeding opening and two tangential admissions lead to
Road is separately positioned on being separated by end points of polygonized structure)；Or the feeding opening and each tangential admission passage, respectively according to
(if using end points where feeding opening as No. 2 end points, two tangential admissions lead at the secondary even numbers apex end for being arranged on polygonized structure
Road is separately positioned on No. 4 and No. 6 end points, this actually mean that feeding opening and two tangential admission passages be separately positioned on it is polygon
Shape structure is separated by end points), the feeding opening and opening of each tangential admission passage in tangential rotating drum side wall, form
Equilateral triangle (in the case of being only provided with a feeding opening and two tangential admission passages) or equilateral polygon (are provided with one
In the case of individual feeding opening and multiple tangential admission passages) position relationship.
Specifically, symmetric polygonal or regular polygon structure centered on the cross section of above-mentioned hollow cavity inwall.
In Fig. 7, Fig. 8, technical scheme is functionally made up of two parts：First, the tangential admission of bottom, water
Flat rotation dispersed structure (i.e. tangential rotating drum) 53, big powder formulation aggregate is in this rotating drum due to the work of centrifugal force
With with the more collisions of tangential rotating drum cavity wall 53-1 generations；Simultaneously because tangential rotating drum is in level when in use
Or close to horizontal state, the effect based on gravity, big powder formulation aggregate is increased in tangential rotating drum cavity
The holdup time is rotated, the shear action of air-flow is also relatively strong in this rotating drum, is all advantageous to powder formulation agglomerated particle
It is scattered.
Second, the tubulose bending dispensing passage 55 of favorable current ascent direction, powder formulation agglomerated particle is from tangential rotating drum
Center exports 54 by the powder formulation of tangential rotating drum, enters bending dispensing passage 55 with air-flow, in bending dispensing passage,
Relatively large heavier powder formulation aggregate, can be with the vias inner walls face of bending dispensing passage again due to poor with fluidity
(or repeatedly) collide, so as to realize the further separation of powder formulation subparticle.
The characteristics of technical solution of the present invention is：Powder formulation enters a horizontally disposed tangential rotation from powder passage 52 is entered
Chamber 53, sheared by air-flow and collided with tangential rotating drum cavity wall 53-1, carry out depolymerization powder formulation.It is in operation principle
On take full advantage of the Action of Gravity Field of centrifugal action and particle in itself when particle does horizontal circular movement so that bulky grain
Powder formulation aggregate in the presence of the two power in the increased retention of chamber, so as to more thorough pharmaceutical dispersions powder.
Further, technical scheme, in the gas circuit of tangential rotating drum back segment or gas passage, set,
One section of bending dispensing passage 55 is added, in bending dispensing passage 55, powder aggregate F2, can be with folding due to poor with fluidity
(or multiple) collides the cavity wall of curved dispensing passage again, so as to realize further dividing for powder formulation subparticle
From.
The present invention is due to better than existing similar DPI products, therefore for the system of identical type in the principle that separates, be atomized
Agent powder, the chamber size of required tangential rotating drum can be done smaller, you can reach the equal dispersiveness of other products
Energy and effect.
For example, for the powder spray that certain is specified, dispersion chamber inscribed circle diameter 12mm, height 3mm of the present invention, and it is existing
Dispersion chamber inscribed circle diameter 16mm, height 4.5mm in technology；By actual Comparability test, dispersion effect between the two
It is essentially identical.
It can be seen that after further optimization of the technical program in scattered/atomization mechanism and fogging flow passage structure, taking
On the premise of obtaining identical dispersion effect, the design for tangential rotating drum can be to use smaller size, and then can contract
The overall volume of small whole powder vapor inhalator product.
Due to DPI products be usually the filling pattern of multiple dose (consideration based on use cost, it is single dose, disposable
DPI products it is few, be generally all to use reused DPI products, i.e. alleged " multiple dose " in the industry), user needs
Often to carry with, then the design of smaller product size, can provide more conveniences for patient.
On the basis of said structure and scattered/atomization, as shown in Figure 9, technical scheme is in the bending
At least side of the outlet section (or being by taking the outlet section of bending dispensing passage as an example at suction nozzle, in figure) of dispensing passage, also sets up
Have at least one bypass air inlet 56 (in figure by taking two bypass air inlets as an example, using symmetrically arranged two bypass air inlets,
Can avoid producing the runner of the powder formulation in bending dispensing passage " changed course " interference), to adjust powder vapor inhalator
Overall suction resistance so that device suction when will not be very laborious.
As shown in figure 12, the cross-sectional area of a bypass air inlet, or the cross-sectional area sum II of two bypass air inlets,
Less than or equal to the 30% of bending dispensing passage port of export cross-sectional area I.
In technical solution of the present invention, preferably bypass air inlet cross-sectional area sum and be no more than cross-sectional area at suction nozzle
20%.
As for doser involved in the technical program, refer to what the applicant applied before this, publication date is
On October 14th, 2015, Publication No. CN104971411A, the Chinese invention patent of entitled " a kind of powder spray doser "
Application, part 3 therein be with doser involved in the technical program, due to being set in the upper surface of the part
There is quantitative drug slot 3a, then the gas entered from primary air inlet 51, through medicine feeding hole 51-2, you can will easily quantify in drug slot
Powder formulation be sent into powder passage.
Embodiment：
Table 1 show prior art and the deposition in vitro experiment (n=3) of the present invention, and experiment is carried out respectively with two medicines
Evaluation, and statistical analysis has been done to laboratory mean values, because FPF directly reflects the depolymerization dispersibility of device, numerical value gets over Gao Ze
Depolymerization dispersibility is stronger.From medicine 1 and the FPF average values of medicine 2, in tangential rotating drum using smaller design size
In the case of, scattered/depolymerization ability of the invention is not less than prior art.The MMAD data of medicine 1 and medicine 2 in stream oriented device connect
Closely.
Pharmacy prescription is to grind certainly used by experiment, experimental flow rate 60L/min：
The deposition in vitro of table 1 tests (n=3)
Figure 11 and Figure 12 represents that the deposition in vitro of medicine 1 and medicine 2 in existing similar DPI products and the present invention is real respectively
Test profiles versus.What it is because of inhalation technique functions therapeutic action is the fine drug particle that can be efficiently entering lung, experiment in vitro
It is less and less that middle stage1 to MOC levels represents drug particle granularity, from data in table, is set in tangential rotating drum using smaller
In the case of counting size, the present invention is upper substantially equivalent with existing similar DPI products from distribution.
In table 1 and Figure 11-12, its implication of used letter abbreviations is as follows：
DD (Delivered dose) dosage delivered；FPD (Fine particle dose) minuteness particle dosage；FPF
(Fine particle fraction) minuteness particle fraction；MMAD (Middle mass aerodynamic diamiter) is empty
Diameter in aerodynamics quality；APSD (Aerodynamic particle size distribution) aerodynamic particle size
Distribution.
Due to technical scheme, by redesigning the tactic pattern and functional module of disperseing runner, change
Enter the mutual alignment relation of powder passage and rotating separation chamber, extend delay of the bulky grain powder formulation particle in split cavity
Time；Bending dispensing passage is set by being exported in rotating separation chamber, using making bulky grain powder formulation particle and cavity wall again
The 26S Proteasome Structure and Function pattern that secondary (or repeatedly) collides, can more thorough pharmaceutical dispersions powder, further better ensure that
The separation of powder spray micro mist aggregate subparticle, atomizing effect.
It the method can be widely used in design, the manufacturing field of the powder spray doser of all size.
Claims (11)
1. a kind of fogging runner for powder vapor inhalator, described fogging runner be arranged on powder storage/
Between administration unit and suction nozzle, it is characterized in that：
Described fogging runner is at least made up of enter powder passage, tangential rotating drum and the bending dispensing passage that penetrate successively；
Described tangential rotating drum is the hollow cavity for the flat disc structure that a height is less than its diameter；
In the side wall of tangential rotating drum；It is provided with least two tangential admission passages；A tangential admission passage therein is same
When also serve as feeding opening；Described at least two tangential admission passages, which are centrosymmetric to be distributed in, forms tangential rotating drum envelope circle
On circumference；
Among the top of the tangential rotating drum, upward powder formulation outlet is provided with；
The central axis of powder formulation outlet and the plane where tangential rotating drum horizontal center line are perpendicular；
The outlet of powder storage/administration unit is connected with entering the top of powder passage, enters the end of powder passage and tangential rotating drum
Feeding opening connects；The powder formulation outlet of tangential rotating drum is connected with the head end of bending dispensing passage, the end of bending dispensing passage
End is connected with suction nozzle；
The lateral cross section entered where powder passage horizontal center line, it is mutually overlapping with the lateral cross section where tangential rotating drum horizontal center line
Close or parallel.
The air-flow entered in powder passage or each tangential admission passage, by it is coplanar laterally cut in a manner of enter described middle cavity
In body；
Enter powder passage or the gas passage of each tangential admission passage and the gas rotating passage of tangential rotating drum is tangent, tangential
Swirling eddy is formed in rotating drum.
Described bending dispensing passage is used to touch the powder spray powder aggregate after the separation of tangential rotating drum again
Hit, and will be by the rotating separation and powder spray powder of collision rift is delivered at suction nozzle again, for user's suction；
When user's actual use powder vapor inhalator carries out suction medicine, the cross-section of the tangential rotating drum is in horizontal
State；Or the cross section of the tangential rotating drum and the angle of horizontal plane are less than 45 degree.
2. according to the fogging runner for powder vapor inhalator described in claim 1, it is characterized in that described bending
Dispensing passage is made up of the first Connectivity Section, bending segment and the second Connectivity Section being sequentially communicated；
The head end of first Connectivity Section forms the head end of bending dispensing passage, connection corresponding with the outlet of tangential rotating drum；
The port of export connection corresponding with the head end of bending segment of first Connectivity Section, the end of the bending segment and the second Connectivity Section
Entrance point corresponding connect；
The port of export connection corresponding with suction nozzle of second Connectivity Section；
Described the first Connectivity Section, bending segment and the second Connectivity Section, form a bending similar to zigzag or reverse-s shape shape
Channel design.
3. according to the fogging runner for powder vapor inhalator described in claim 2, it is characterized in that described first connects
The horizontal center line of logical section is parallel with the horizontal center line of tangential rotating drum；The horizontal center line of second Connectivity Section and tangential rotation
The horizontal center line for turning chamber coincides；Plane and the second Connectivity Section horizontal center line institute where first Connectivity Section horizontal center line
Plane parallel.
4. according to the fogging runner for powder vapor inhalator described in claim 1, it is characterized in that described preparation
Runner is atomized, is made up of three parts of component in runner lower member, runner and runner upper member.
5. according to the fogging runner for powder vapor inhalator described in claim 4, it is characterized in that described runner
Lower member forms the bottom into powder passage and tangential rotating drum；
Component forms the side wall and top into powder passage and tangential rotating drum, and the bottom of bending dispensing passage in described runner
Portion and side wall；
Described runner upper member forms the top of bending dispensing passage.
6. according to the fogging runner for powder vapor inhalator described in claim 1, it is characterized in that the middle cavity
The cross section of internal wall is a polygonized structure, the feeding opening and each tangential admission passage, is successively set on respectively more
At the odd number apex end of side shape structure；Or the feeding opening and each tangential admission passage, polygon is successively set on respectively
At the even numbers apex end of structure.
7. according to the fogging runner for powder vapor inhalator described in claim 6, it is characterized in that described is polygon
Symmetric polygonal or regular polygon centered on shape structure.
8. according to the fogging runner for powder vapor inhalator described in claim 1, it is characterized in that described is tangential
Rotating drum, the aggregate of powder formulation is solved by rotating horizontally scattered mode of operation, when being moved in a circle using particle
The Action of Gravity Field of centrifugal action and particle in itself so that bulky grain powder formulation aggregate is being cut in the presence of the two power
To the increased retention of rotating drum, so as to more thoroughly pharmaceutical dispersions powder aggregate, and through being located at tangential rotating drum top
Powder formulation outlet output to bending dispensing passage.
9. according to the fogging runner for powder vapor inhalator described in claim 1, it is characterized in that in described folding
In curved dispensing passage, powder formulation aggregate can occur again due to poor with fluidity with the cavity wall of bending dispensing passage
Collision, so as to realize the further separation or atomization of powder formulation aggregate.
10. according to the fogging runner for powder vapor inhalator described in claim 1, it is characterized in that in the bending
At least side of the outlet section of dispensing passage, at least one bypass air inlet is provided with, to adjust powder vapor inhalator
Overall suction resistance.
11. according to the fogging runner for powder vapor inhalator described in claim 10, it is characterized in that one
The cross-sectional area of air inlet, or the cross-sectional area sum of two bypass air inlets are bypassed, is gone out less than or equal to bending dispensing passage
The 30% of mouth end cross-sectional area.
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| CN201710946859.5A CN107737393B (en) | 2017-10-12 | 2017-10-12 | Preparation atomization flow passage for powder aerosol inhalation device |
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| CN201710946859.5A CN107737393B (en) | 2017-10-12 | 2017-10-12 | Preparation atomization flow passage for powder aerosol inhalation device |
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| CN107737393B CN107737393B (en) | 2020-08-28 |
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| CN110201280A (en) * | 2018-02-28 | 2019-09-06 | 张江 | Suction nozzle and inbalation administration device for inbalation administration device |
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| WO2023011015A1 (en) * | 2021-08-03 | 2023-02-09 | 上海秀新臣邦医药科技有限公司 | Single-dose disposable powder aerosol inhalation device |
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| CN107737393B (en) | 2020-08-28 |
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