CN107736363A - A kind of blood component pathogen inactivator and preparation method thereof - Google Patents
A kind of blood component pathogen inactivator and preparation method thereof Download PDFInfo
- Publication number
- CN107736363A CN107736363A CN201711070066.8A CN201711070066A CN107736363A CN 107736363 A CN107736363 A CN 107736363A CN 201711070066 A CN201711070066 A CN 201711070066A CN 107736363 A CN107736363 A CN 107736363A
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- CN
- China
- Prior art keywords
- parts
- blood component
- pathogen inactivator
- psoralen
- riboflavin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0076—Radiation using a photocatalyst or photosensitiser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Abstract
The invention discloses a kind of blood component pathogen inactivator and preparation method thereof, its raw material is as follows by weight：4 parts of 35 parts of glucose, 67 parts of HES, 60 70 parts of physiological saline, 57 parts of potassium chloride, 57 parts of magnesium chloride, 12 parts of sodium acid carbonate, 24 parts of calcium gluconate, 56 parts of maltose, 13 parts of lactose, 13 parts of galactolipin, 25 parts of mannitol, 47 parts of riboflavin, 68 parts of psoralen and PEN2.It is of the invention compared with conventional pathogen inactivator, adding riboflavin can effectively inactivation of viruses, bacterium, protozoon, leucocyte-removing can also be removed, the setting of psoralen, hematoblastic metabolism can be accelerated, reduce platelet aggregation, PEN setting, can prevent the duplication of pathogen nucleic acid, and inactivating efficacy is good, prepared using gnotobasis, more safely and effectively.
Description
Technical field
The invention belongs to medical field, more specifically, more particularly to a kind of blood component pathogen inactivator.Meanwhile
The invention further relates to a kind of preparation method of blood component pathogen inactivator.
Background technology
Blood transfusion is the important support means of modern medicine, and the whole blood of clinical infusion is one kind by blood plasma and various haemocyte structures
Into broad sense connective tissue, whole blood can be separated erythroblast, blood platelet, granulocyte, blood plasma and cryoprecipitate with physical method
Deng blood constituent, the Transfusion that blood constituent is respectively used to various disease treatment is referred to as component blood transfusion.Due to defeated with whole blood
Note compares, and component blood transfusion has that clinical effectiveness is notable, adverse reaction rate is low, be easy to preserve and to save blood resource etc. excellent
Point, thus be widely adopted, turn into the principal mode of clinical blood transfusion.
The research for including the pathogen including virus using photochemical method inactivation blood is that blood transfusion medical science is led in recent years
By the research direction of extensive concern in domain, its principle is that pathogen inactivator-sensitising agent is added in whole blood or blood constituent,
After light irradiation, sensitiser absorption luminous energy, electronics transfer can occur or excite to produce singlet molecular oxygen, in nucleic acid specific region shape
Into covalent additive compound or the skeleton structure for destroying nucleic acid to reach pathogen inactivated effect, sensitising agent is finally filtered out, is made
The standby blood constituent into safety.
The main method for adding pathogen inactivator both at home and abroad at present is to be directly added into low-concentration liquid pathogen inactivator,
The pathogen inactivated sensitising agent agent of liquid can quickly degrade in low concentration and lose pathogen inactivated effect；Also have using solid type
Pathogen inactivator, has that single dose is inaccurate, uneven, and is difficult the nothing for solving pathogen inactivator and added auxiliary material
Bacterium, apyrogeneity and the problem without particulate matter, and the pathogen treated is more single, and use range is small.
The content of the invention
It is an object of the invention to provide a kind of blood component pathogen inactivator and preparation method thereof, to solve the above-mentioned back of the body
The problem of being proposed in scape technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of blood component pathogen inactivator, its raw material are as follows by weight：Glucose 3-5 parts, HES 6-7 parts,
Physiological saline 60-70 parts, potassium chloride 5-7 parts, magnesium chloride 5-7 parts, sodium acid carbonate 1-2 parts, calcium gluconate 2-4 parts, maltose
5-6 parts, lactose 1-3 parts, galactolipin 1-3 parts, mannitol 2-5 parts, riboflavin 4-7 parts, psoralen 6-8 parts and PEN2-4 parts.
Preferably, the glucose, HES, physiological saline, potassium chloride, magnesium chloride, calcium gluconate, malt
Sugar, lactose, galactolipin and mannitol are injection-grade auxiliary material.
Preferably, the PEN is positively charged second bromine imine derivative.
A kind of preparation method of blood component pathogen inactivator, comprises the following steps：
S1, by glucose, HES, physiological saline, potassium chloride, magnesium chloride, calcium gluconate, maltose, lactose, gala
Sugar and mannitol are fully dissolved, then riboflavin, psoralen and PEN are added in the solution；
S2, activated needle-use activated carbon is added into solution, needle-use activated carbon is to be used to inhale using vegetalitas charcoal is manufactured
The Injectable active charcoal of attached thermal source, impurity pigment, and stir 10-20min, then adds sensitising agent, then solution is put into quiet
Put and 1-2h is stood in bucket, take supernatant liquor；
Sodium acid carbonate is added in S3, the supernatant liquor obtained into S2, changes pH, is swashed riboflavin, psoralen and PEN
It is living, form anchor-shaped bonding effect compounds.
Preferably, it is dissolved in gnotobasis and operates in S1, and temperature is less than 40 DEG C.
Preferably, mean particle dias of the S2 at the middle and upper levels in clear liquid is not more than 20um.
Compared with prior art, the beneficial effects of the invention are as follows：It is of the invention compared with conventional pathogen inactivator, add core
Flavine can effectively inactivation of viruses, bacterium, protozoon, leucocyte-removing can also be removed, the setting of psoralen, blood platelet can be accelerated
Metabolism, reduce platelet aggregation, PEN setting, the duplication of pathogen nucleic acid can be prevented, inactivating efficacy is good, and use is sterile
Prepared by environment, more safely and effectively.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
A kind of blood component pathogen inactivator, its raw material are as follows by weight：Glucose 3-5 parts, HES 6-7
Part, physiological saline 60-70 parts, potassium chloride 5-7 parts, magnesium chloride 5-7 parts, sodium acid carbonate 1-2 parts, calcium gluconate 2-4 parts, malt
Sugared 5-6 parts, lactose 1-3 parts, galactolipin 1-3 parts, mannitol 2-5 parts, riboflavin 4-7 parts, psoralen 6-8 parts and PEN2-4
Part.
Specifically, the glucose, HES, physiological saline, potassium chloride, magnesium chloride, calcium gluconate, malt
Sugar, lactose, galactolipin and mannitol are injection-grade auxiliary material.
Specifically, the PEN is positively charged second bromine imine derivative.
Present invention also offers a kind of preparation method of blood component pathogen inactivator, comprise the following steps：
S1, by glucose, HES, physiological saline, potassium chloride, magnesium chloride, calcium gluconate, maltose, lactose, gala
Sugar and mannitol are fully dissolved, then riboflavin, psoralen and PEN are added in the solution；
S2, activated needle-use activated carbon is added into solution, needle-use activated carbon is to be used to inhale using vegetalitas charcoal is manufactured
The Injectable active charcoal of attached thermal source, impurity pigment, and stir 10-20min, then adds sensitising agent, then solution is put into quiet
Put and 1-2h is stood in bucket, take supernatant liquor；
Sodium acid carbonate is added in S3, the supernatant liquor obtained into S2, changes pH, is swashed riboflavin, psoralen and PEN
It is living, form anchor-shaped bonding effect compounds.
Operated specifically, being dissolved in S1 in gnotobasis, and temperature is less than 40 DEG C.
Specifically, mean particle dias of the S2 at the middle and upper levels in clear liquid is not more than 20um.
It is of the invention compared with conventional pathogen inactivator, addition riboflavin can effectively inactivation of viruses, bacterium, protozoon, and also
It can remove leucocyte-removing, the setting of psoralen, hematoblastic metabolism can be accelerated, reduce platelet aggregation, PEN setting,
The duplication of pathogen nucleic acid can be prevented, inactivating efficacy is good, is prepared using gnotobasis, more safely and effectively, and is being matched somebody with somebody
Sensitising agent is with the addition of in solution, facilitates irradiation inactivated, it is pathogen inactivated to solve current blood plasma or blood constituent progress photochemistry
Pathogen inactivator science prepare and addition problem.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (6)
- A kind of 1. blood component pathogen inactivator, it is characterised in that：Its raw material is as follows by weight：Glucose 3-5 parts, hydroxyl second Base starch 6-7 parts, physiological saline 60-70 parts, potassium chloride 5-7 parts, magnesium chloride 5-7 parts, sodium acid carbonate 1-2 parts, calcium gluconate 2-4 parts, maltose 5-6 parts, lactose 1-3 parts, galactolipin 1-3 parts, mannitol 2-5 parts, riboflavin 4-7 parts, psoralen 6-8 parts With PEN2-4 parts.
- A kind of 2. blood component pathogen inactivator according to claim 1, it is characterised in that：The glucose, hydroxyl second Base starch, physiological saline, potassium chloride, magnesium chloride, calcium gluconate, maltose, lactose, galactolipin and mannitol are injection stage Auxiliary material.
- A kind of 3. blood component pathogen inactivator according to claim 1, it is characterised in that：The PEN is positively charged The second bromine imine derivative of lotus.
- 4. the preparation method of the blood component pathogen inactivator described in a kind of claim 1, it is characterised in that including following step Suddenly：S1, by glucose, HES, physiological saline, potassium chloride, magnesium chloride, calcium gluconate, maltose, lactose, gala Sugar and mannitol are fully dissolved, then riboflavin, psoralen and PEN are added in the solution；S2, activated needle-use activated carbon is added into solution, needle-use activated carbon is to be used to inhale using vegetalitas charcoal is manufactured The Injectable active charcoal of attached thermal source, impurity pigment, and stir 10-20min, then adds sensitising agent, then solution is put into quiet Put and 1-2h is stood in bucket, take supernatant liquor；Sodium acid carbonate is added in S3, the supernatant liquor obtained into S2, changes pH, is swashed riboflavin, psoralen and PEN It is living, form anchor-shaped bonding effect compounds.
- A kind of 5. preparation method of blood component pathogen inactivator according to claim 1, it is characterised in that：It is molten in S1 Solution operates in gnotobasis, and temperature is less than 40 DEG C.
- A kind of 6. preparation method of blood component pathogen inactivator according to claim 1, it is characterised in that：The S2 The mean particle dia in clear liquid is not more than 20um at the middle and upper levels.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711070066.8A CN107736363A (en) | 2017-11-03 | 2017-11-03 | A kind of blood component pathogen inactivator and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711070066.8A CN107736363A (en) | 2017-11-03 | 2017-11-03 | A kind of blood component pathogen inactivator and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107736363A true CN107736363A (en) | 2018-02-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711070066.8A Pending CN107736363A (en) | 2017-11-03 | 2017-11-03 | A kind of blood component pathogen inactivator and preparation method thereof |
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| CN (1) | CN107736363A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1494450A (en) * | 2001-12-05 | 2004-05-05 | ���ع��ʹ�˾ | Manual processing systems and methods for providing blood components conditioned for pathogen inactivation |
| CN1857741A (en) * | 2006-06-01 | 2006-11-08 | 上海市血液中心 | Pathogen inactivator composition for blood or blood component and its compounding process |
-
2017
- 2017-11-03 CN CN201711070066.8A patent/CN107736363A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1494450A (en) * | 2001-12-05 | 2004-05-05 | ���ع��ʹ�˾ | Manual processing systems and methods for providing blood components conditioned for pathogen inactivation |
| CN1857741A (en) * | 2006-06-01 | 2006-11-08 | 上海市血液中心 | Pathogen inactivator composition for blood or blood component and its compounding process |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180227 |
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| RJ01 | Rejection of invention patent application after publication |