CN107715176A - A kind of preparation method of the nanofiber coating support of promotion osteanagenesis - Google Patents
A kind of preparation method of the nanofiber coating support of promotion osteanagenesis Download PDFInfo
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- CN107715176A CN107715176A CN201711055532.5A CN201711055532A CN107715176A CN 107715176 A CN107715176 A CN 107715176A CN 201711055532 A CN201711055532 A CN 201711055532A CN 107715176 A CN107715176 A CN 107715176A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0092—Electro-spinning characterised by the electro-spinning apparatus characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The invention belongs to field of tissue engineering technology.It is high for magnesium alloy bracket degradation rate in the prior art, the problem of corrosion-resistant, the invention discloses a kind of preparation method of the nanofiber coating support of promotion osteanagenesis, gelatin (Gel) and Ciprofloxacin (Cip) are dissolved in organic solution and prepare spinning solution first, then Gel Cip layers of nanofibers is collected in Ca Mg alloy surfaces by electrostatic spinning technique, then crosslinking obtains the Mg Ca alloy brackets with Gel Cip nanofiber coatings in glutaraldehyde steam.Preparation method of the present invention is simple, and the Gel Cip nanofiber coating Mg Ca alloy brackets of preparation have higher corrosion resistance, biocompatibility and antibiotic property, are had broad application prospects in terms of the nano coating fibrous material for osteanagenesis.
Description
Technical field
The present invention relates to a kind of preparation method of the nanofiber coating support of promotion osteanagenesis, belong to organizational project neck
Domain.
Background technology
Cranial defect and osteonecrosis are Orthopedic Clinical common surgicals as caused by wound, inflammation, bone tumour excision etc., are faced at present
It is used for the repair and reconstruction of Cranial defect on bed frequently with bone renovating materials such as stainless steel, titanium alloy, polymer and ceramics, but by it
The limitation of own physical, chemistry and biological property, the effect of Bone Defect Repari still have much room for improvement.
Magnesium is trace element necessary to human body, and certain density magnesium ion can promote the propagation of cartilage cell and divide
Change, be advantageous to Subchondral drilling, after in magnesium alloy implantation human body, its surface can be transformed into the phosphate of new bone tissue by generating
Layer, with the extension of Implantation Time, new bone just constantly grows on magnesium alloy implant, due to magnesium alloy in human body with good
Good biocompatibility and degradability, magnesium alloy do not need extra operation to remove after the implantation, it is considered to be most have at present
One of biomaterial of attraction, it is the preferred material of clinical implant.But because the chemism of magnesium and its alloy is strong, its
Corrosion resistance is poor, and degradation rate is high, caused inflammatory reaction and limits magnesium alloy therefrom the problems such as cell compatibility and exists
The application of field of tissue engineering technology.
Gelatin (Gel) is used as a kind of native biopolymer material, has good biological degradability and biocompatibility,
Magnesium alloy bracket surface is deposited on using gelatin as protective layer, the degradation rate of magnesium alloy bracket can be reduced, if again will be anti-
Raw element such as Ciprofloxacin (Cip) medicine is incorporated into the growth that bacterial cell can be also prevented in gelatin and the infection of bone.
Electrostatic spinning is very thin liquid stream to be formed, when these liquid streams to high molecular attraction in solution using high-pressure electrostatic
In solvent volatilization after i.e. form fiber.The nanofiber prepared using electrostatic spinning technique has higher specific surface area and hole
Gap rate, it is capable of the structure of analog cell epimatrix, gelatin nanometer is prepared on magnesium alloy bracket surface according to electrostatic spinning technique
Fiber drug-carried coat, then the degradation rate of magnesium alloy bracket can be substantially reduced, improve its biocompatibility and antibacterial activity, promoted
Enter the growth and reparation of bone tissue.However, at present on preparing Gel-Cip nanofiber coating supports using electrostatic spinning technique
Method there is not been reported.
The content of the invention
For the problems of the prior art, the present invention provides a kind of preparation for the nanofiber coating support for promoting osteanagenesis
Method, to reduce the degradation rate of magnesium alloy bracket, improve its biocompatibility.
To realize above technical purpose, the technical scheme is that:
A kind of preparation method of the nanofiber coating support of promotion osteanagenesis, comprises the following steps:
(1) Gel is dissolved in 98% organic solution, then adds Cip and 12~24h is stirred at room temperature to obtain blend spinning molten
Liquid.
(2) spinning solution prepared by (1) is transferred in syringe, syringe adds a diameter of 1~5mm No. 5 stainless steels
Syringe needle, using 0.5~5ml/L fltting speed, spinning voltage 10~40KV, Mg-Ca alloy base material is placed on aluminium foil, and setting connects
10~30cm of distance is received, collects Gel-Cip layers of nanofibers.
(3) by (2) prepare the Mg-Ca alloys with layers of nanofibers be placed in cross-linking reaction 1 in glutaraldehyde steam~
24h, produce Gel-Cip nanofiber coating Mg-Ca alloy brackets.
As a kind of embodiment, Gel mass percentage concentration is 10~30% in spinning solution in described step (1),
Cip mass percentage concentration is 2~10% in spinning solution.
As a kind of embodiment, the organic solution in described step (1) is formic acid solution.
As a kind of embodiment, the gelatin weight average molecular weight in described step (1) is 1~100,000.
As a kind of embodiment, Ca accounts for 1~10wt% in the Mg-Ca alloy base materials in the step (2).
From the above, it can be seen that the present invention has advantages below:
(1) present invention prepares Gel-Cip nanofiber coatings, Gel- by electrostatic spinning on Mg-Ca alloy base materials surface
Cip nanofiber coatings can reduce the degradation rate of Mg-Ca alloy brackets as protective layer, improve the resistance to of Mg-Ca alloy brackets
Corrosivity;
(2) present invention from gelatin as can spinning polymer, the nanofiber coating of preparation can be made there is good biology
Compatibility and degradability;
(3) present invention is handed over Gel-Cip layers of nanofibers with glutaraldehyde as cross linker using the method for vapor crosslinking
Connection is modified, and the mechanical performance and heat endurance of nanofiber coating can be improved, by controlling the degree of cross linking of gelatin to control
The degradation rate of nanofiber coating processed;
(4) present invention adds antibiotic co-blended spinning, and antibiotic uniform load is in nanofiber coating, and with crosslinking
The swelling of gelatin slowly discharges, and can effectively prevent the growth of bacterial cell and the infection of bone;
Embodiment
Below by examples of implementation, the features of the present invention is expanded on further, but the present invention is not limited to embodiment.
Embodiment 1:
(1) the as cast condition Mg-2wt%Ca samples that size is 15mm (diameter) × 2mm (thickness), mechanical wet-milling are prepared;
(2) Gel that weight average molecular weight is 50,000 is dissolved in 98% formic acid solution, then adds Cip and 12h is stirred at room temperature
Obtain blend spinning liquid.The mass percentage concentration that Gel mass percentage concentration is 20%, Cip in spinning solution is 5%, and room temperature is stirred
Mix 12h and obtain blend spinning liquid.
(3) spinning solution prepared by (2) is transferred in 10ml syringes, syringe adds a diameter of 3mm No. 5 stainless steels
Syringe needle, using 1ml/L fltting speed, spinning voltage 20KV, Mg-Ca alloy base material is placed on aluminium foil, is set and is received distance
15cm, collect Gel-Cip layers of nanofibers.
(4) sample with layers of nanofibers prepared by (3) is placed in after vacuum drying chamber 24h removes residual solvent and put again
The cross-linking reaction 12h in glutaraldehyde steam, produce Gel-Cip nanofiber coating Mg-Ca alloy brackets.Embodiment 2:
(1) the as cast condition Mg-10wt%Ca samples that size is 15mm (diameter) × 2mm (thickness), mechanical wet-milling are prepared;
(2) Gel that weight average molecular weight is 10,000 is dissolved in 98% formic acid solution, then adds Cip and 24h is stirred at room temperature
Obtain blend spinning liquid.The mass percentage concentration that Gel mass percentage concentration is 10%, Cip in spinning solution is 2%.
(3) spinning solution prepared by (2) is transferred in 10ml syringes, syringe adds a diameter of 1mm No. 5 stainless steels
Syringe needle, using 5ml/L fltting speed, spinning voltage 10KV, Mg-Ca alloy base material is placed on aluminium foil, is set and is received distance
30cm, collect Gel-Cip layers of nanofibers.
(4) sample with layers of nanofibers prepared by (3) is placed in after vacuum drying chamber 24h removes residual solvent and put again
The cross-linking reaction 1h in glutaraldehyde steam, produce Gel-Cip nanofiber coating Mg-Ca alloy brackets.
Embodiment 3:
(1) the as cast condition Mg-1wt%Ca samples that size is 15mm (diameter) × 2mm (thickness), mechanical wet-milling are prepared;
(2) Gel that weight average molecular weight is 100,000 is dissolved in 98% formic acid solution, then adds Cip and 24h is stirred at room temperature
Obtain blend spinning liquid.The mass percentage concentration that Gel mass percentage concentration is 30%, Cip in spinning solution is 10%.
(3) spinning solution prepared by (2) is transferred in 10ml syringes, syringe adds a diameter of 5mm No. 5 stainless steels
Syringe needle, using 0.5ml/L fltting speed, spinning voltage 40KV, Mg-Ca alloy base material is placed on aluminium foil, is set and is received distance
10cm, collect Gel-Cip layers of nanofibers.
(4) sample with layers of nanofibers prepared by (3) is placed in after vacuum drying chamber 24h removes residual solvent and put again
The cross-linking reaction 24h in glutaraldehyde steam, produce Gel-Cip nanofiber coating Mg-Ca alloy brackets.
Using hank ' s simulated body fluids as corrosive medium, by Mg-Ca alloy samples, Gel-Cip nanofiber coatings Mg-
Ca alloy samples, which are respectively placed in corrosive medium, soaks 48h at 37 DEG C, calculate the front and rear weight-loss ratio of corrosion;By nanofiber coating
Mg-Ca alloy samples are implanted into medical subcutaneous rat, observe whether there is inflammatory reaction at implant alloy after 5 days;It the results are shown in Table 1.
Sample | Embodiment 1 | Embodiment 2 | Embodiment 3 | Mg-Ca alloy samples |
Weight-loss ratio | 25% | 18% | 32% | 45% |
Whether there is inflammatory reaction | Nothing | Nothing | Nothing | Have |
It is understood that above with respect to the specific descriptions of the present invention, it is merely to illustrate the present invention and is not limited to this
Technical scheme described by inventive embodiments.It will be understood by those within the art that still the present invention can be carried out
Modification or equivalent substitution, to reach identical technique effect;As long as meet use needs, all protection scope of the present invention it
It is interior.
Claims (5)
1. a kind of preparation method of the nanofiber coating support of promotion osteanagenesis, comprises the following steps:
(1) Gel is dissolved in 98% organic solution, then addition Cip is stirred at room temperature 12~24h and obtains spinning mixed solution.
(2) spinning solution prepared by (1) being transferred in syringe, syringe adds a diameter of 1~5mm No. 5 stainless steel syringe needles,
Using 0.5~5ml/L fltting speed, spinning voltage 10~40KV, Mg-Ca alloy base material is placed on aluminium foil, set receive away from
From 10~30cm, Gel-Cip layers of nanofibers.
(3) the Mg-Ca alloys with layers of nanofibers prepared by (2) are placed in 1~24h of cross-linking reaction in glutaraldehyde steam, i.e.,
Obtain Gel-Cip nanofiber coating Mg-Ca alloy brackets.
2. preparation method according to claim 1, it is characterised in that in described step (1) in spinning solution Gel quality
Percentage concentration is 10~30%, and Cip mass percentage concentration is 2~10% in spinning solution.
3. preparation method according to claim 1, it is characterised in that the organic solution in described step (1) is formic acid
Solution.
4. preparation method according to claim 1, it is characterised in that the gelatin weight average molecular weight in described step (1)
For 1~100,000.
5. preparation method according to claim 1, it is characterised in that in the Mg-Ca alloy base materials in described step (2)
Ca accounts for 1~10wt%.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111939330A (en) * | 2020-07-22 | 2020-11-17 | 苏州晶俊新材料科技有限公司 | Zinc alloy anastomosis nail and preparation method thereof |
CN114575037A (en) * | 2022-03-09 | 2022-06-03 | 诺一迈尔(苏州)生命科技有限公司 | Electrostatic spinning nanofiber membrane and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1857742A (en) * | 2005-04-30 | 2006-11-08 | 中国科学院金属研究所 | Biomedicine implant material with controllable degrading rate and its application |
CN1961974A (en) * | 2005-11-09 | 2007-05-16 | 中国科学院化学研究所 | Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof |
CN101214396A (en) * | 2008-01-03 | 2008-07-09 | 乐普(北京)医疗器械股份有限公司 | Controlled degradation magnesium alloy coating bracket and preparation thereof |
WO2009020797A2 (en) * | 2007-08-03 | 2009-02-12 | Abbott Cardiovascular Systems Inc. | Polymers for implantable devices exhibiting shape-memory effects |
CN103611190A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Method of preparing controlled-release antibacterial film and implant material by using antibacterial composition |
CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof |
CN107106695A (en) * | 2014-08-05 | 2017-08-29 | 孟斐斯大学 | Composition and method for the healing and the regeneration that strengthen bone and soft tissue |
-
2017
- 2017-10-31 CN CN201711055532.5A patent/CN107715176A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1857742A (en) * | 2005-04-30 | 2006-11-08 | 中国科学院金属研究所 | Biomedicine implant material with controllable degrading rate and its application |
CN1961974A (en) * | 2005-11-09 | 2007-05-16 | 中国科学院化学研究所 | Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof |
WO2009020797A2 (en) * | 2007-08-03 | 2009-02-12 | Abbott Cardiovascular Systems Inc. | Polymers for implantable devices exhibiting shape-memory effects |
CN101214396A (en) * | 2008-01-03 | 2008-07-09 | 乐普(北京)医疗器械股份有限公司 | Controlled degradation magnesium alloy coating bracket and preparation thereof |
CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof |
CN103611190A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Method of preparing controlled-release antibacterial film and implant material by using antibacterial composition |
CN107106695A (en) * | 2014-08-05 | 2017-08-29 | 孟斐斯大学 | Composition and method for the healing and the regeneration that strengthen bone and soft tissue |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111939330A (en) * | 2020-07-22 | 2020-11-17 | 苏州晶俊新材料科技有限公司 | Zinc alloy anastomosis nail and preparation method thereof |
CN114575037A (en) * | 2022-03-09 | 2022-06-03 | 诺一迈尔(苏州)生命科技有限公司 | Electrostatic spinning nanofiber membrane and preparation method thereof |
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