CN107694941A - A kind of classified screening device prepared for nanoscale drug particles - Google Patents
A kind of classified screening device prepared for nanoscale drug particles Download PDFInfo
- Publication number
- CN107694941A CN107694941A CN201710946582.6A CN201710946582A CN107694941A CN 107694941 A CN107694941 A CN 107694941A CN 201710946582 A CN201710946582 A CN 201710946582A CN 107694941 A CN107694941 A CN 107694941A
- Authority
- CN
- China
- Prior art keywords
- pillar
- drug particles
- screening device
- device prepared
- nanoscale drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B9/00—Combinations of apparatus for screening or sifting or for separating solids from solids using gas currents; General arrangement of plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/28—Moving screens not otherwise provided for, e.g. swinging, reciprocating, rocking, tilting or wobbling screens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/4609—Constructional details of screens in general; Cleaning or heating of screens constructional details of screening surfaces or meshes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/4609—Constructional details of screens in general; Cleaning or heating of screens constructional details of screening surfaces or meshes
- B07B1/4636—Regulation of screen apertures
Abstract
The invention discloses a kind of classified screening device prepared for nanoscale drug particles,Including base,The upper surface of base is provided with support frame,Sorting unit is provided with support frame,Support frame includes fix bar,Left pillar and right pillar,Fix bar is arranged between left pillar and right pillar,Sorting unit includes two installation disks,Two installation disks are separately positioned on the top of left pillar and right pillar,Several micropores are provided with two installation disks,The top of installation disk is provided with sieve membrane,Sieve membrane is made up of several CNTs,Deflector chute is provided with the right side of two installation disk bottoms,The upper surface of base is placed with rewinding case,Rewinding case is arranged on the underface of the deflector chute on the right pillar top installation disk,It is simple in construction,It can realize that nano-grade medicine prepares the function of sizing screening,And screening effect is good,Efficiency high,It can effectively solve the problem that the problem of background technology proposes,It is worthy to be popularized.
Description
Technical field
The present invention relates to nano-grade medicine production technical field, specially a kind of point prepared for nanoscale drug particles
Level screening plant.
Background technology
With the development of medical technology, use of the nano-grade medicine in terms of medical treatment is more and more extensive, and in many nanometers
In the production of medicine, generally require that the particle diameter of drug particles is consistent, the manufacture method of conventional Nano medication has chemical reduction method, gas
Phase sedimentation, sol-gal process etc., because reaction condition influence and course of reaction are difficult to accurately control, these methods are made to be difficult to obtain
The Nano medication particle of uniform particle diameter is obtained, thus need to be by other methods, as by screening as receiving prepared by the above method
Rice drug particles product, as long as making the aperture of screening plant consistent and reaching the nanometer medicine that nanoscale can obtain uniform particle diameter
Thing.
Existing nanoscale drug particles screening is often made up of supporter and nm-class sieve-membrane, wherein, supporter has micron
Level filter opening, nm-class sieve-membrane are made up of γ-MnO2, and the hole of nm-class sieve-membrane is formed by γ-MnO2 molecule intervals, sieve membrane
Average pore size is 2-3nm, and γ-MnO2 initial sizes are 20-30nm, and aggregation particle diameter is 100-500nm, thicknesses of layers 10-
15um, still, its hole are formed by the interval of molecule, thus hole area is smaller relative to the area of whole sieve membrane, i.e.,
Percent opening is smaller, it is impossible to makes full use of its effective area, causes the sieve membrane to screen rate reduction.
The content of the invention
In order to overcome the shortcomings of prior art, the present invention provides a kind of classification prepared for nanoscale drug particles
Screening plant, it is simple in construction, it can realize that nano-grade medicine prepares the function of sizing screening, and screening effect is good, efficiency high, energy
It is effective to solve the problems, such as background technology proposition, it is worthy to be popularized.
The technical solution adopted for the present invention to solve the technical problems is：A kind of point prepared for nanoscale drug particles
Level screening plant, including base, the upper surface of the base are provided with support frame, sorting unit are provided with support frame as described above,
Support frame as described above includes fix bar, left pillar and right pillar, and the fix bar is arranged between left pillar and right pillar, described point
Screening device includes two installation disks, and two installation disks are separately positioned on the top of left pillar and right pillar, two institutes
State and several micropores are provided with installation disk, the top of the installation disk is provided with sieve membrane, and the sieve membrane is by some
Individual CNT composition, two installation disk bottoms right side are provided with deflector chute, and the upper surface of the base is placed with
Rewinding case, the rewinding case are arranged on the underface of the deflector chute on the right pillar top installation disk.
As a kind of preferable technical scheme of the present invention, the bottom of the left pillar and right pillar is provided with vibration dress
Put, the vibrating device includes motor, rotating shaft and vibrating mass, and the motor is arranged on the upper surface of base, the rotating shaft right-hand member
Linked together with the output shaft of motor, left end and the vibrating mass of the rotating shaft are linked together, and the upper surface of the base is set
Fixed block is equipped with, the inside of the fixed block is hollow-core construction, and the vibrating mass is arranged on the inside of fixed block, the left pillar
Fixed block is both passed through with the bottom of right pillar to link together with vibrating mass.
As a kind of preferable technical scheme of the present invention, the left pillar and right pillar are by upper cylinder and lower cylinder
The inside of composition, the upper cylinder and lower cylinder is hollow-core construction, and the upper cylinder and lower cylinder pass through fastening
Screw connects together, and the diameter of the upper cylinder is less than the diameter of lower cylinder.
As a kind of preferable technical scheme of the present invention, the CNT is distributed in disordered state, and the carbon is received
The ulking thickness of mitron can be adjusted arbitrarily.
As a kind of preferable technical scheme of the present invention, the angle of the deflector chute and vertical direction is at 45 degree to six
Between ten degree.
It is micro- at 100 microns to 150 as a kind of preferable technical scheme of the present invention, the pore size of the micropore
Between rice.
As a kind of preferable technical scheme of the present invention, the installation disk is mixed by ceramic material and composite fibre materials
It is made.
As a kind of preferable technical scheme of the present invention, the connection between the CNT is connected using two dimension and three-dimensional
Connected mode.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) present invention installs disks by setting two, realizes the function that nanoscale drug particles prepare sizing screening,
Simple to operate, required hand labor is less, saves certain production cost.
(2) present invention is by setting CNT, on the one hand, greatly strengthen the screening effect of sieve membrane, makes it to nanometer
The screening speed of level drug particles serves the effect of promotion；On the other hand, can be changed by adjusting the ulking thickness of CNT
The aperture become between CNT, so as to change the screening aperture of sieve membrane, meets the needs of production；Furthermore due to CNT
With higher mechanical performance and nanometer grade diameter so that the sieve membrane being made up of CNT has high-specific surface area and porous
The features such as, so as to solve the problems, such as that Conventional nano sieve membrane percent opening is small, screening efficiency is low.
Brief description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is the vibrating device structural representation of the present invention；
Fig. 3 is the left corbeling schematic diagram of the present invention；
Fig. 4 is the microcellular structure schematic diagram of the present invention.
In figure：1- bases；2- support frames；3- sorting units；4- fix bars；The left pillars of 5-；The right pillars of 6-；7- installation circles
Disk；8- micropores；9- sieve membranes；10- CNTs；11- deflector chutes；12- rewinding casees；13- vibrating devices；14- motors；15- rotating shafts；
16- vibrating mass；17- fixed blocks；The upper cylinders of 18-；Cylinder under 19-；20- fastening screws.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other under the premise of creative work is not made
Embodiment, belong to the scope of protection of the invention.
The explanation of following embodiment is refer to the attached drawing, can be to the specific embodiment implemented to the example present invention.
The direction and position term that the present invention is previously mentioned, for example, " on ", " in ", " under ", "front", "rear", "left", "right", " interior ", "
Outside ", " side " etc., only it is direction and position with reference to annexed drawings.Therefore, the direction and position term used is to illustrate
And understand the present invention, and it is not used to the limitation present invention.
Embodiment：
As shown in Figure 1 and Figure 4, a kind of classified screening device prepared for nanoscale drug particles, including base 1, institute
The upper surface for stating base 1 is provided with support frame 2, and sorting unit 3 is provided with support frame as described above 2, and support frame as described above 2 includes fixing
Bar 4, left pillar 5 and right pillar 6, the fix bar 4 are arranged between left pillar 5 and right pillar 6, by fix bar 4 by left branch
Post 5 and right pillar 6 are linked together, and the sorting unit 3 includes two installation disks 7, and two installation disks 7 are set respectively
The top in left pillar 5 and right pillar 6 is put, several micropores 8, the installation circle are provided with two installation disks 7
The top of disk 7 is provided with sieve membrane 9, and the sieve membrane 9 is made up of several CNTs 10, two installation disk 7 bottoms
Right side is provided with deflector chute 11, and the upper surface of the base 1 is placed with rewinding case 12, and the rewinding case 12 is arranged on the right side
The underface of deflector chute 11 on the top of pillar 6 installation disk 7, during screening, nanoscale drug particles are first passed through on left pillar 5
The sieve membrane 9 on the top of disk 7 is installed, after the screening of sieve membrane 9, from installation disk 7 top that deflector chute 11 is flowed on right pillar 6
Sieve membrane 9, after its screening, enter rewinding case 12 from deflector chute 11, wherein, the sieve membrane on disk 7 is installed on the right pillar 6
9 aperture is less than the aperture for the sieve membrane 9 installed on the left pillar 5 on disk 7；The CNT 10 is in disordered state point
Cloth, and the ulking thickness of the CNT 10 can be adjusted arbitrarily, it is each at its by Van der Waals force between the CNT 10
Individual contact position be combined with each other and forms a large amount of filter openings, so as to realize the effect of screening and filtering, by changing CNT 10
Ulking thickness realizes the change of filter opening size, and the ulking thickness of CNT 10 is bigger, and the filter opening of formation is smaller；Conversely, accumulation
Thickness it is smaller, the filter opening of formation is bigger；The angle of the deflector chute 11 and vertical direction 45 degree to 60 degree it
Between, the convenient nanoscale drug particles after screening enter next screening link, meanwhile, also allow for collecting the nanometer after screening
Level medicine；The installation disk 7 is mixed by ceramic material and composite fibre materials, makes installation disk 7 more durable in use,
Extend the service life of installation disk 7；Connection between the CNT 10 is connected using two dimension and three-dimensional connected mode,
So that the screening efficiency for the sieve membrane 9 being made up of CNT 10 is higher, screening effect is more preferable；The pore size of the micropore 8 exists
Between 100 microns to 150 microns.
As shown in Fig. 2 the bottom of the left pillar 5 and right pillar 6 is provided with vibrating device 13, the vibrating device 13
Including motor 14, rotating shaft 15 and vibrating mass 16, the motor 14 is arranged on the upper surface of base 1, the right-hand member of rotating shaft 15 and electricity
The output shaft of machine 14 links together, and left end and the vibrating mass 16 of the rotating shaft 15 link together, the upper surface of the base 1
Fixed block 17 is provided with, the inside of the fixed block 17 is hollow-core construction, and the vibrating mass 16 is arranged on the inside of fixed block 17,
The bottom of the left pillar 5 and right pillar 6 both passes through fixed block 17 and linked together with vibrating mass 16, the setting of vibrating device 13
Serve the effect of vibration so that installation disk 7 shakes in screening process, so as to accelerate the screening efficiency of sieve membrane 9.
As shown in figure 3, the left pillar 5 and right pillar 6 form by upper cylinder 18 and lower cylinder 19, the upper circle
The inside of cylinder 18 and lower cylinder 19 is hollow-core construction, and the upper cylinder 18 and lower cylinder 19 pass through fastening screw 20
Connect together, and the diameter of the upper cylinder 18 is less than the diameter of lower cylinder 19, realizes left pillar 5 and right pillar 6
The highly function of regulation, so as to meet production requirement.
In summary, the main characteristic of the invention lies in that：
(1) present invention installs disks by setting two, realizes the function that nanoscale drug particles prepare sizing screening,
Simple to operate, required hand labor is less, saves certain production cost.
(2) present invention is by setting CNT, on the one hand, greatly strengthen the screening effect of sieve membrane, makes it to nanometer
The screening speed of level drug particles serves the effect of promotion；On the other hand, can be changed by adjusting the ulking thickness of CNT
The aperture become between CNT, so as to change the screening aperture of sieve membrane, meets the needs of production；Furthermore due to CNT
With higher mechanical performance and nanometer grade diameter so that the sieve membrane being made up of CNT has high-specific surface area and porous
The features such as, so as to solve the problems, such as that Conventional nano sieve membrane percent opening is small, screening efficiency is low.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.Any reference in claim should not be considered as to the involved claim of limitation.
Claims (8)
1. a kind of classified screening device prepared for nanoscale drug particles, including base (1), the upper table of the base (1)
Face is provided with support frame (2), and sorting unit (3) is provided with support frame as described above (2), it is characterised in that：Support frame as described above (2) wraps
Fix bar (4), left pillar (5) and right pillar (6) are included, the fix bar (4) is arranged between left pillar (5) and right pillar (6),
The sorting unit (3) includes two installation disks (7), and two installation disks (7) are separately positioned on left pillar (5) and the right side
The top of pillar (6), two described install are provided with several micropores (8) on disks (7), the top of the installation disk (7)
End is provided with sieve membrane (9), and the sieve membrane (9) is made up of several CNTs (10), two described installation disk (7) bottoms
Right side is provided with deflector chute (11), and the upper surface of the base (1) is placed with rewinding case (12), and the rewinding case (12) is set
The underface of deflector chute (11) on right pillar (6) the top installation disk (7).
A kind of 2. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
The bottom of the left pillar (5) and right pillar (6) is provided with vibrating device (13), and the vibrating device (13) includes motor
(14), rotating shaft (15) and vibrating mass (16), the motor (14) are arranged on the upper surface of base (1), rotating shaft (15) right-hand member
Linked together with the output shaft of motor (14), left end and the vibrating mass (16) of the rotating shaft (15) link together, the bottom
The upper surface of seat (1) is provided with fixed block (17), and the inside of the fixed block (17) is hollow-core construction, and the vibrating mass (16) sets
Put in the inside of fixed block (17), the bottom of the left pillar (5) and right pillar (6) both passes through fixed block (17) and vibrating mass
(16) link together.
A kind of 3. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
The left pillar (5) and right pillar (6) form by upper cylinder (18) and lower cylinder (19), the upper cylinder (18) and
The inside of lower cylinder (19) is hollow-core construction, and the upper cylinder (18) and lower cylinder (19) pass through fastening screw (20)
Connect together, and the diameter of the upper cylinder (18) is less than the diameter of lower cylinder (19).
A kind of 4. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
The CNT (10) is distributed in disordered state, and the ulking thickness of the CNT (10) can be adjusted arbitrarily.
A kind of 5. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
The angle of the deflector chute (11) and vertical direction is between 45 degree to 60 degree.
A kind of 6. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
The pore size of the micropore (8) is between 100 microns to 150 microns.
A kind of 7. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
The installation disk (7) is mixed by ceramic material and composite fibre materials.
A kind of 8. classified screening device prepared for nanoscale drug particles according to claim 1, it is characterised in that：
Connection between the CNT (10) is using two dimension connection and three-dimensional connected mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710946582.6A CN107694941A (en) | 2017-10-12 | 2017-10-12 | A kind of classified screening device prepared for nanoscale drug particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710946582.6A CN107694941A (en) | 2017-10-12 | 2017-10-12 | A kind of classified screening device prepared for nanoscale drug particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107694941A true CN107694941A (en) | 2018-02-16 |
Family
ID=61183607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710946582.6A Pending CN107694941A (en) | 2017-10-12 | 2017-10-12 | A kind of classified screening device prepared for nanoscale drug particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107694941A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070051240A1 (en) * | 2005-05-28 | 2007-03-08 | Hon Hai Precision Industry Co., Ltd. | Nano-scale filter and method for making the same |
| JP4521599B2 (en) * | 2004-11-08 | 2010-08-11 | 本多電子株式会社 | Sieve device |
| CN202079023U (en) * | 2011-04-21 | 2011-12-21 | 合肥旭阳铝颜料有限公司 | Integral three-unit grading vibration sieve device |
| CN203470316U (en) * | 2013-08-24 | 2014-03-12 | 宣城市百草植物工贸有限公司 | Device for screening drug particles |
| CN204320638U (en) * | 2014-06-06 | 2015-05-13 | 上海电机学院 | Multi-stage screening machine |
| CN204866536U (en) * | 2015-07-05 | 2015-12-16 | 上海朗亿功能材料有限公司 | Little nanometer powder clears away equipment |
| CN106925511A (en) * | 2017-05-16 | 2017-07-07 | 辽宁科技大学 | Electric vertical straight-line oscillation type cereal grading plant |
-
2017
- 2017-10-12 CN CN201710946582.6A patent/CN107694941A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4521599B2 (en) * | 2004-11-08 | 2010-08-11 | 本多電子株式会社 | Sieve device |
| US20070051240A1 (en) * | 2005-05-28 | 2007-03-08 | Hon Hai Precision Industry Co., Ltd. | Nano-scale filter and method for making the same |
| CN202079023U (en) * | 2011-04-21 | 2011-12-21 | 合肥旭阳铝颜料有限公司 | Integral three-unit grading vibration sieve device |
| CN203470316U (en) * | 2013-08-24 | 2014-03-12 | 宣城市百草植物工贸有限公司 | Device for screening drug particles |
| CN204320638U (en) * | 2014-06-06 | 2015-05-13 | 上海电机学院 | Multi-stage screening machine |
| CN204866536U (en) * | 2015-07-05 | 2015-12-16 | 上海朗亿功能材料有限公司 | Little nanometer powder clears away equipment |
| CN106925511A (en) * | 2017-05-16 | 2017-07-07 | 辽宁科技大学 | Electric vertical straight-line oscillation type cereal grading plant |
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| PB01 | Publication | ||
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Application publication date: 20180216 |