CN107669690A - A kind of tablet containing aspirin and clopidogrel - Google Patents
A kind of tablet containing aspirin and clopidogrel Download PDFInfo
- Publication number
- CN107669690A CN107669690A CN201710995639.1A CN201710995639A CN107669690A CN 107669690 A CN107669690 A CN 107669690A CN 201710995639 A CN201710995639 A CN 201710995639A CN 107669690 A CN107669690 A CN 107669690A
- Authority
- CN
- China
- Prior art keywords
- clopidogrel
- aspirin
- layer
- stomach
- tablet containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
Abstract
The present invention discloses a kind of tablet containing aspirin and clopidogrel, includes aspirin layer inner core, enteric layer, clopidogrel or its medicinal salt deposit, layer soluble in the stomach respectively from inside to outside；Beneficial effect：A kind of tablet containing aspirin and clopidogrel of the present invention can effectively treat pathological condition, angiocarpy and the cerebrovascular system disease induced by platelet aggregation, and to coat of the stomach not damaged, be advantageous to the clothes for patients use to aspirin intolerance.
Description
Technical field
The present invention relates to pharmaceutical arts, more particularly to a kind of tablet containing aspirin and clopidogrel.
Background technology
The current medicament comprising aspirin and clopidogrel is generally the shape of tablet, gel capsule or single dose bag
Formula, then Aspirin tablet may cause coat of the stomach to damage in the form of the above.
The content of the invention
It is an object of the invention to provide a kind of tablet containing aspirin and clopidogrel, with solution in the prior art
The shortcomings that easily causing coat of the stomach to damage.
Technical scheme:A kind of tablet containing aspirin and clopidogrel, includes Ah Si respectively from inside to outside
Woods layer inner core, enteric layer, clopidogrel or its medicinal salt deposit, layer soluble in the stomach.
The aspirin layer inner core includes acetylsalicylic acid or its pharmaceutical salts.
The layer soluble in the stomach includes at least one stomach tolerance polymer and the weight at least 35% of polymer is resistant to relative to stomach
Sodium bicarbonate.
The enteric layer includes hydroxypropyl ethyl cellulose and POLYPROPYLENE GLYCOL.
A kind of method of the tablet of aspirin and clopidogrel, comprises the following steps：
S1. aspirin layer inner core is prepared；
S2. aspirin layer inner core is coated, and then obtains enteric layer；
S3. enteric layer is coated, and then obtains clopidogrel or its medicinal salt deposit；
S4. clopidogrel or its medicinal salt deposit are coated, and then obtain layer soluble in the stomach, and be pressed into containing aspirin and chlorine pyrrole
The tablet of Gray.
Beneficial effect：A kind of tablet containing aspirin and clopidogrel of the present invention can be treated effectively by platelet aggregation
Collect pathological condition, angiocarpy and the cerebrovascular system disease of induction, and to coat of the stomach not damaged, be advantageous to aspirin intolerance
Clothes for patients use.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Embodiment
Herein below is to combine specific preferred embodiment further description made for the present invention, it is impossible to is assert
The specific implementation of the present invention is confined to these explanations.
As shown in figure 1, a kind of tablet containing aspirin and clopidogrel of the present embodiment, includes Ah Si respectively from inside to outside
Woods layer inner core 1, enteric layer 2, clopidogrel or its medicinal salt deposit 3, layer soluble in the stomach 4.
The aspirin layer inner core 1 includes acetylsalicylic acid or its pharmaceutical salts.
The layer soluble in the stomach 4 includes at least one stomach tolerance polymer and the weight at least 35% of polymer is resistant to relative to stomach
Sodium bicarbonate.
The enteric layer 2 includes hydroxypropyl ethyl cellulose and POLYPROPYLENE GLYCOL.
A kind of method of the tablet of aspirin and clopidogrel, comprises the following steps：
S1. aspirin layer inner core 1 is prepared；
S2. aspirin layer inner core 1 is coated, and then obtains enteric layer 2；
S3. enteric layer 2 is coated, and then obtains clopidogrel or its medicinal salt deposit 3；
S4. clopidogrel or its medicinal salt deposit 3 are coated, and then obtain layer 4 soluble in the stomach, and be pressed into containing aspirin and chlorine
The tablet of pyrrole Gray.
For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise,
Some simple deduction or replace can also be made, should all be considered as belonging to protection scope of the present invention.
Claims (4)
1. a kind of tablet containing aspirin and clopidogrel, it is characterised in that include respectively in aspirin layer from inside to outside
Core, enteric layer, clopidogrel or its medicinal salt deposit, layer soluble in the stomach.
A kind of 2. tablet containing aspirin and clopidogrel according to claim 1, it is characterised in that the Ah Si
Woods layer inner core includes acetylsalicylic acid or its pharmaceutical salts.
A kind of 3. tablet containing aspirin and clopidogrel according to claim 1, it is characterised in that the layer soluble in the stomach
Polymer is resistant to including at least one stomach and the sodium bicarbonate of the weight at least 35% of polymer is resistant to relative to stomach.
A kind of 4. tablet containing aspirin and clopidogrel according to claim 1, it is characterised in that the enteric layer
Including hydroxypropyl ethyl cellulose and POLYPROPYLENE GLYCOL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710995639.1A CN107669690A (en) | 2017-10-23 | 2017-10-23 | A kind of tablet containing aspirin and clopidogrel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710995639.1A CN107669690A (en) | 2017-10-23 | 2017-10-23 | A kind of tablet containing aspirin and clopidogrel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107669690A true CN107669690A (en) | 2018-02-09 |
Family
ID=61140989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710995639.1A Withdrawn CN107669690A (en) | 2017-10-23 | 2017-10-23 | A kind of tablet containing aspirin and clopidogrel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107669690A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212180A (en) * | 2022-09-03 | 2022-10-21 | 深圳市信宜特科技有限公司 | Compound preparation of aspirin and clopidogrel hydrogen sulfate and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1993112A (en) * | 2004-07-29 | 2007-07-04 | 赛诺菲-安万特 | Pharmaceutical multilayer tablet for controlled release of active ingredients with highly pH-dependent solubility |
| CN103906506A (en) * | 2011-09-14 | 2014-07-02 | 波曾公司 | Controlled dosing of clopidogrel with gastric acid inhibition therapies |
| CN103957895A (en) * | 2011-11-02 | 2014-07-30 | 韩国联合制药株式会社 | Complex agent containing clopidogrel and aspirin |
| CN105407877A (en) * | 2013-08-02 | 2016-03-16 | 赛诺菲 | Pharmaceutical tablet comprising acetylsalicylic acid and clopidogrel |
| WO2017037741A1 (en) * | 2015-09-02 | 2017-03-09 | Sun Pharmaceutical Industries Ltd | Compact solid dosage form of aspirin and clopidogrel |
| WO2017160101A1 (en) * | 2016-03-16 | 2017-09-21 | 한국유나이티드제약 주식회사 | Composite preparation containing clopidogrel and aspirin |
-
2017
- 2017-10-23 CN CN201710995639.1A patent/CN107669690A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1993112A (en) * | 2004-07-29 | 2007-07-04 | 赛诺菲-安万特 | Pharmaceutical multilayer tablet for controlled release of active ingredients with highly pH-dependent solubility |
| CN103906506A (en) * | 2011-09-14 | 2014-07-02 | 波曾公司 | Controlled dosing of clopidogrel with gastric acid inhibition therapies |
| CN103957895A (en) * | 2011-11-02 | 2014-07-30 | 韩国联合制药株式会社 | Complex agent containing clopidogrel and aspirin |
| CN105407877A (en) * | 2013-08-02 | 2016-03-16 | 赛诺菲 | Pharmaceutical tablet comprising acetylsalicylic acid and clopidogrel |
| WO2017037741A1 (en) * | 2015-09-02 | 2017-03-09 | Sun Pharmaceutical Industries Ltd | Compact solid dosage form of aspirin and clopidogrel |
| WO2017160101A1 (en) * | 2016-03-16 | 2017-09-21 | 한국유나이티드제약 주식회사 | Composite preparation containing clopidogrel and aspirin |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212180A (en) * | 2022-09-03 | 2022-10-21 | 深圳市信宜特科技有限公司 | Compound preparation of aspirin and clopidogrel hydrogen sulfate and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180209 |