CN107668065A - A kind of Karbofos emulsion in water and preparation method thereof - Google Patents
A kind of Karbofos emulsion in water and preparation method thereof Download PDFInfo
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- CN107668065A CN107668065A CN201710953009.8A CN201710953009A CN107668065A CN 107668065 A CN107668065 A CN 107668065A CN 201710953009 A CN201710953009 A CN 201710953009A CN 107668065 A CN107668065 A CN 107668065A
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- water
- emulsion
- stabilizer
- karbofos
- thickener
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to technical field of pesticide preparations, more particularly to a kind of Karbofos emulsion in water and preparation method thereof, Karbofos emulsion in water, include the raw material of following mass fraction：Malathion, 20~60%；Organic solvent, 0~15%；Emulsifying agent, 2~15%；Antifreezing agent, 0.5~5%；Thickener, 0~3%；Stabilizer, 5~11%；Co-stabilizer, 3~8%；Water, 9~51%；By preparing the emulsion with narrow droplet diameter distribution, compared to a kind of monodispersed few Ostwald ripenings of emulsion, hence it is evident that narrow liquid footpath can be realized when being distributed in processing, while pass through the interaction of emulsifying agent, thickener and stabilizer, electrostatic and steric stabilization are provided, prevent flocculation and coalescence；Reduce layering and sedimentation；In addition, co-stabilizer is under the interaction of other components, malathion can be improved in water stability, the aqueous emulsion drug effect is more preferable, safe, has a extensive future.
Description
Technical field
The invention belongs to technical field of pesticide preparations, more particularly to a kind of Karbofos emulsion in water and preparation method thereof.
Background technology
Malathion category low toxic pesticide, the longevity of residure is short, tags and certain fumigation action with good, makees without interior inhale
With.Malathion is stronger to the virulence of insect, and malaoxon, the latter's anticholinesterase vigor are mainly oxidized in pest body
1000 times of enhancing.But malathion is very low to the toxicity of people and animals, rat oral LD50 is 1635~l752mg/kg, percutaneously
LD50 is 4000~6150mg/kg, and its reason is that malathion hydrolyzes in mammalian body under phosphoesterase action, is lost
Activity, and lack this enzyme in insect bodies, malathion and its oxidation product malaoxon are unable to hydrolytic inactivation, therefore to the poison of insect
Property is with regard to larger.Therefore the insect for a variety of biting mouthpartses being widely used on the crops such as preventing and treating rice, sorghum, vegetables, fruit tree.Also
Available for the insect on the crops such as preventing and treating tobacco, tea and mulberry tree.It can also be used for preventing and treating stored grain insects.To mosquito, fly, lice, tick, mite,
Bedbug has killing action.With wide spectrum, low toxicity, it is safe to use the features such as.
Currently, malathion formulation in market is mainly to have 45% missible oil based on traditional liquor missible oil, 25% finish,
70% high-quality missible oil (pest control phosphorus) etc., substantial amounts of organic solvent is must be added to when producing missible oil, these organic solvents are again with inflammable
Based on explosive, harmful to people and animals, pollution environment benzene class, it is absolutely unsafe during production, storing and use, developed country is
Forbid or part forbids using on fruit tree, vegetables.In addition, the largely valuable industrial chemicals without drug effect is sprayed onto Tanaka,
It is a kind of wasting of resources.The missible oil of agricultural chemicals yield 50% -60% is accounted for, every year to expend 250,000 tons of as many as 1,000,000,000 yuan of values has
Solvent.Meanwhile contain substantial amounts of organic solvent in missible oil, often play the role of to aggravate poisoning to tender flowers and fruits；Microemulsion
With contain substantial amounts of water in aqueous emulsion, the poisoning to plant is often light than the missible oil of same active ingredient.Therefore, with water
Instead of or reduce organic solvent novel form aqueous emulsion and microemulsion, will progressively substitute conventional dosage forms --- missible oil.Especially
Aqueous emulsion, its organic solvent used in being formulated and surfactant are all fewer than missible oil and microemulsion, therefore are referred to as environmentally friendly agriculture
Pharmaceutically dosage form.
But Karbofos emulsion in water is unstable, including physical property is unstable, and easily layering or sedimentation, can make formulation
Uniformity is destroyed, and effective content has concentration of liquid drops gradient；Malathion belongs to organic phosphorus compound simultaneously, existing for water
Under environment, chemical property it is unstable.
The content of the invention
The present invention solves above-mentioned technical problem present in prior art, there is provided a kind of Karbofos emulsion in water and its preparation
Method.
To solve the above problems, technical scheme is as follows：
A kind of Karbofos emulsion in water, include the raw material of following mass fraction：
Malathion, 20~60%；
Organic solvent, 0~15%；
Emulsifying agent, 2~15%；
Antifreezing agent, 0.5~5%；
Thickener, 0~3%；
Stabilizer, 5~11%；
Co-stabilizer, 3~8%；
Water, 9~51%；
The stabilizer is any one in antioxidant 264, epoxychloropropane, epoxidized soybean oil, benzoyl peroxide.
The co-stabilizer is N, the salicylidene -1,3- diaminopropanes of N '-two.
Preferably, the organic solvent is any one in toluene, dimethylbenzene, benzene, C10 aromatic hydrocarbons.
Preferably, the emulsifying agent is calcium dodecyl benzene sulfonate, K-12, alkylnaphthalene sulfonate, Nonyl pheno
Ether, alkylaryl APEO, polyoxyethylene carboxylate, PO-EO block polyethers, polycarboxylate, polyethylene glycol hydrogenated castor
Any one or a few combination in sesame oil salt, styryl phosphate.
Preferably, the antifreezing agent is any one in ethylene glycol, glycerine, isopropanol, butanol.
Preferably, the thickener is any one in aluminium-magnesium silicate, organobentonite, xanthans, carboxymethyl cellulose.
The preparation method of Karbofos emulsion in water, comprises the following steps, and the malathion active compound and the mailing is molten
Agent is sufficiently mixed, and adds the co-stabilizer, then emulsifying agent is added, and is stirred, so as to obtain aqueous emulsion oil phase；By institute
Antifreezing agent, stabilizer, thickener and water mixing are stated, as aqueous phase, under high shear or homogenizer effect, in batches or slowly by water
Oil phase is added to, is sheared half an hour, discharging.
Relative to prior art, advantages of the present invention is as follows,
The present invention is few compared to a kind of monodispersed emulsion by preparing the emulsion with narrow droplet diameter distribution
Ostwald ripening, hence it is evident that narrow liquid footpath can be realized when being distributed in processing, while pass through the mutual of emulsifying agent, thickener and stabilizer
Effect, there is provided electrostatic and steric stabilization, prevent flocculation and coalescence；Reduce layering and sedimentation；In addition, co-stabilizer is other groups
Point interaction under, malathion can be improved in water stability, prevent its decomposition；Breast of the aqueous emulsion drug effect than same amount
The drug effect of oil formulation is more preferable, higher than missible oil to the security of plant, and lower than missible oil to the toxicity of warm-blooded animal, and application prospect is wide
It is wealthy.
Embodiment
Embodiment 1：
A kind of Karbofos emulsion in water, include the raw material of following mass fraction：
Malathion, 20%；
Emulsifying agent, 15%；
Antifreezing agent, 0.5%；
Thickener, 3%；
Stabilizer, 6%；
N, N salicylidene -1, the 3- diaminopropanes of '-two, 5%；
Water, 50.5%；
Wherein, the stabilizer is antioxidant 264, and the organic solvent is toluene, and emulsifying agent is DBSA
Calcium, antifreezing agent are ethylene glycol, and thickener is organobentonite.
The preparation method of above-mentioned Karbofos emulsion in water, comprises the following steps, by the malathion active compound and the postal
Post solvent to be sufficiently mixed, add the co-stabilizer, then emulsifying agent is added, stir, so as to obtain aqueous emulsion oil phase；
The antifreezing agent, stabilizer, thickener and water are mixed, as aqueous phase, under high shear or homogenizer effect, in batches or slowly
Aqueous phase is added into oil phase, sheared half an hour, discharging.
Embodiment 2：
With embodiment 1, following components (mass fraction) is only changed：
Malathion, 60%；
Organic solvent, 5%；
Emulsifying agent, 8%；
Antifreezing agent, 5%；
Stabilizer, 5%；
N, N salicylidene -1, the 3- diaminopropanes of '-two, 8%；
Water, 9%.
The stabilizer is benzoyl peroxide, and organic solvent is benzene, and emulsifying agent is alkylnaphthalene sulfonate, polyoxyethylene nonyl phenyl
The mass mixing things such as vinethene, Crodaret salt, antifreezing agent are isopropanol, and thickener is carboxymethyl cellulose.
Embodiment 3：
Malathion, 40%；
Organic solvent, 15%；
Emulsifying agent, 2%；
Antifreezing agent, 3%；
Thickener, 2%；
Stabilizer, 9%；
N, N salicylidene -1, the 3- diaminopropanes of '-two, 7%；
Water, 22%.
The stabilizer is epoxidized soybean oil, and organic solvent is C10 aromatic hydrocarbons, and emulsifying agent is PO-EO block polyethers, styrene
The mass mixing thing such as based phosphates, antifreezing agent are butanol, and thickener is aluminium-magnesium silicate.
Embodiment 4：
Malathion, 41%；
Organic solvent, 7%；
Emulsifying agent, 7%；
Antifreezing agent, 3%；
Thickener, 2%；
Stabilizer, 11%；
N, N salicylidene -1, the 3- diaminopropanes of '-two, 3%；
Water, 26%.
The stabilizer is epoxychloropropane, and organic solvent is dimethylbenzene, and emulsifying agent is alkylaryl APEO, excellent
Selection of land, the antifreezing agent are glycerine, and thickener is xanthans.
Embodiment 5：
Karbofos emulsion in water empirical tests obtained by above example meet or reached index listed in Table
The Karbofos emulsion in water quality index of table 1
Embodiment 6：
The Karbofos emulsion in water field control effectiveness test result of the present invention
Field control effectiveness test has been carried out, mainly rice hoppers are carried out with controlling experiment, experiment sets 5 processing altogether, repeats 4
It is secondary, completely random district's groups arrangement, cell and accumulate 33m2.Spraying time is in mid-August, planthopper three generations's larva full incidence period dispenser one
Secondary, medicine prelarva density is 47211/667m2, using the type knapsack hand sprayer of workers and peasants -16, spouting liquid 120ml/
667m2, even spraying is in rice middle and upper part.Diagonal sampling in 10th day after medicine, investigation, calculates preventive effect, dispenser 3d by 5 clumps every
Preventive effect reaches 73.7% afterwards.The medicament is also smaller to natural enemy lethal effect to rice safety, while has necessarily to rice leaf roller
Preventive effect.
Embodiment 7
50 milliliters are respectively taken to be placed on a glass container with plug sealing the Karbofos emulsion in water obtained by embodiment 1-4
In, it is respectively placed in 54 ± 2 DEG C of constant temperature ovens and carries out an experiment of the accelerating storage of two weeks by a definite date；The resolution ratio of malathion is used
High speed liquid chromatography judges.As a result it is as follows：
The oil-suspending agent of embodiment 1 is not layered, and malathion resolution ratio is 0.9%；
The oil-suspending agent of embodiment 2 is not layered, and malathion resolution ratio is 1.1%；
The oil-suspending agent of embodiment 3 is not layered, and malathion resolution ratio is 0.9%；
The oil-suspending agent of embodiment 3 is not layered, and malathion resolution ratio is 0.8%；
It should be noted that above-described embodiment is only presently preferred embodiments of the present invention, it is not used for limiting the present invention's
Protection domain, the equivalent substitution or replacement made on the basis of the above belong to protection scope of the present invention.
Claims (6)
1. a kind of Karbofos emulsion in water, it is characterised in that include the raw material of following mass fraction：
Malathion, 20~60%；
Organic solvent, 0~15%；
Emulsifying agent, 2~15%；
Antifreezing agent, 0.5~5%；
Thickener, 0~3%；
Stabilizer, 5~11%；
Co-stabilizer, 3~8%；
Water, 9~51%；
The stabilizer is any one in antioxidant 264, epoxychloropropane, epoxidized soybean oil, benzoyl peroxide.
The co-stabilizer is N, the salicylidene -1,3- diaminopropanes of N '-two.
2. Karbofos emulsion in water as claimed in claim 1, it is characterised in that the organic solvent be toluene, dimethylbenzene,
Any one in benzene, C10 aromatic hydrocarbons.
3. Karbofos emulsion in water as claimed in claim 1, it is characterised in that the emulsifying agent is DBSA
Calcium, K-12, alkylnaphthalene sulfonate, NPE, alkylaryl APEO, polyoxyethylene carboxylate, PO-
Any one or a few group in EO block polyethers, polycarboxylate, Crodaret salt, styryl phosphate
Close.
4. Karbofos emulsion in water as claimed in claim 1, it is characterised in that the antifreezing agent is ethylene glycol, glycerine, different
Any one in propyl alcohol, butanol.
5. Karbofos emulsion in water as claimed in claim 1, it is characterised in that the thickener is aluminium-magnesium silicate, organic bentonite
Moisten any one in soil, xanthans, carboxymethyl cellulose.
6. the preparation method of the Karbofos emulsion in water as described in claim any one of 1-5, it is characterised in that including following step
Suddenly, the malathion active compound and the mailing solvent are sufficiently mixed, add the co-stabilizer, then emulsifying agent is added,
Stir, so as to obtain aqueous emulsion oil phase；The antifreezing agent, stabilizer, thickener and water are mixed, as aqueous phase,
Under high shear or homogenizer effect, aqueous phase is added into oil phase in batches or slowly, sheared half an hour, discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710953009.8A CN107668065A (en) | 2017-10-13 | 2017-10-13 | A kind of Karbofos emulsion in water and preparation method thereof |
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| CN201710953009.8A CN107668065A (en) | 2017-10-13 | 2017-10-13 | A kind of Karbofos emulsion in water and preparation method thereof |
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| CN107668065A true CN107668065A (en) | 2018-02-09 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111100163A (en) * | 2019-12-30 | 2020-05-05 | 江苏腾龙生物药业有限公司 | Malathion original drug and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102318640A (en) * | 2011-07-13 | 2012-01-18 | 南京扬子鸿利源化学品有限责任公司 | Karbofos emulsion in water and preparation method thereof |
-
2017
- 2017-10-13 CN CN201710953009.8A patent/CN107668065A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102318640A (en) * | 2011-07-13 | 2012-01-18 | 南京扬子鸿利源化学品有限责任公司 | Karbofos emulsion in water and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 高莉: "飞机燃油抗氧剂膦化物的氧化反应的热力学研究", 《应用化工》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111100163A (en) * | 2019-12-30 | 2020-05-05 | 江苏腾龙生物药业有限公司 | Malathion original drug and preparation method thereof |
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