CN107648611A - The anti-cicatrix externally used preparation of compound Angiotensin-Converting class - Google Patents
The anti-cicatrix externally used preparation of compound Angiotensin-Converting class Download PDFInfo
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Abstract
The present invention provides a kind of anti-cicatrix externally used preparation of compound Angiotensin-Converting class, is made up of one or more ACE classes medicines and other one or more anti-scarring drugs for active principle, and the mass concentration of active ingredient is 0.05% 25% in preparation.ACE classes medicine is the related active peptides of ACE and corresponding inhibitor/antagonist, and other anti-scarring drugs are Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid.Invention formulation cost of material is cheap, low manufacture cost, can reduce treatment cost.The active ingredient of invention formulation is uniformly distributed in preparation in mass ratio, has the ability for preferably penetrating skin barrier, be can be done directly on scar and is carried out multi-angle synergistic treatment, is expected to improve curative effect, is reduced side reaction.This preparation is local topical medicine, is mainly used in the treatment of cicatrix of skin.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of compound Angiotensin-Converting (Angiotensin
Converting enzyme, ACE) the anti-cicatrix externally used preparation of class (ACE related activities peptide and its corresponding inhibitor/antagonist) and
It is prepared.
Background technology
Scar (scar, scar, cicatrix) be caused normal skin tissue after various wounds mode of appearance and
The general designation of the change of histopathology.After it is human body wound, one kind during wound or surface of a wound normal healing is normal,
Inevitable physiological reaction, and the inevitable outcome of wound healing process.The essence of scar is that one kind does not possess normal skin tissue
Structure and physiological function, losing normal structure vigor, abnormal, unsound tissue.
Cicatricial tissue hyperplasia is then likely to form hypertrophic scar, influences the outward appearance of patient, causes cacesthesia, influences
The function of local skin.Wound healing of the skin after sustaining damage goes through several stages:Inflammatory phase, proliferative phase and remodeling phase.
In proliferative phase, body by cytothesis, differentiation and ECM (extracellular matrix) formed supplement or repair due to skin injury and
Cause the tissue for lacking or being damaged.In proliferative phase, the cell of several approach repair tissues is referred to as repair cell more than, into fibre
Dimension cell is one kind of repair cell, and is formed in fibr tissue and played an important role with links such as contraction of wounds;Work as tissue
After the completion of reparation, fibroblast is mainly disappeared by the form of Apoptosis.When fibroblast because of some specific reasons again
When raw increase, apoptosis are reduced, fibr tissue is formed to increase to shrink with granulation tissue and strengthened, thus hypertrophic scar produces.Therefore
Regulation and control to fibroblast regeneration, differentiation perhaps can provide a kind of effective way for suppressing cicatrization.
Fibroblastic propagation is with differentiation mainly by the shadow of cell factor, mechanical stress and extracellular matrix microenvironment
Ring.Wherein TGF-β 1 stimulates fibroblast proliferation by TGF-β signal path and migrated to wound;It can induce into fibre simultaneously
Endochylema of the cell synthesis rich in collagen is tieed up, myofibroblast is divided into so as to induce fibroblast.Endothelium
Local angiotensin system of myocardial (renin-angiotensin system, RAS) plays key player in TGF-β signal path.
In recent years RAS research is found:Local RAS can be a variety of by promoting the synthesis of cell propagation and extracellular matrix to participate in
The formation of histoorgan fibrosis.From the proangiotensin of liver, angiotensin I is converted into the presence of feritin
(angiotensin I, Ang I), Ang I are converted into Angiotensin II (angiotensin II, Ang in the presence of ACE
II), Ang II are secreted into target tissue by blood circulation, are combined with I receptors, cause aldosterone release and vessel retraction etc. raw
Effect is managed, blood pressure and the blood flow change of body is adjusted, maintains body blood volume and water-electrolyte balance.Constantly there is scholar both at home and abroad
The expression for having RAS is found in local organizations such as heart, vascular wall, kidney, fat and brains;Local RAS is independent action, but
Influenced each other again with circulation RAS, participate in a variety of pathophysiological processes jointly.
There is also complete RAS (McGinn R, Meade RD, Kenny GP.Angiotensin II in for skin histology
human skin:an age-dependent role for core temperature regulationAm J Physiol
Heart Circ Physiol.2015,308(10):H1192-3).After normal skin is impaired, RAS is activated, and participates in tissue
Injury repair and later stage tissue reconstruction process.In hyperplastic scar forming process, ACE and Ang II expression increase, and ACE
Activity is significantly higher than normal and trauma skin.The TGF-β signal path that Ang II are mediated by its I receptor induces human desmocyte
The propagation of cell, and this propagation can be suppressed by the antagonist of this receptor (rather than II receptors).
It is the shearing enzyme (Fig. 1) of Several Active Peptides as the ACE of RAS system hinges.Its substrate is except above-mentioned
AngI, in addition to Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (Substance P, SP), N- acetyl group-seryl-aspartoyl-lysyl-proline (N-
Acetyl-seryl-aspartyl-lysyl-proline, AcSDKP), angiotensins-(1-7) (hypertensin 1-7,
Ang 1-7), bradykinin (Bradykinin), enkephalins (Enkephalin), neurotensin (Neurotensin), Chemotactic Peptide
(N- formyl-methionines-Ile-Phe, N-formyl-Met-Leu-Phe, fMLF), insulin B chain
(Insulin b chain) and amyloid (Amyloid peptides) Ab1-40 and Ab1-42 etc. (Bernstein KE,
Ong FS,Blackwell WL,Shah KH,Giani JF,Gonzalez-Villalobos RA,Shen XZ,Fuchs S,
Touyz RM.A modern understanding of the traditional and nontraditional
biological functions of Angiotensin-converting enzyme.Pharmacol Rev.2012,65
(1):1-46.)。
Exogenous SP can effectively facilitate fibroblast proliferation, so as to promote cicatrization.On the contrary, another dropped by ACE
The substrate A cSDKP of solution can then alleviate fibrosis.In addition, though ACE and other enzymes participate in Ang 1-7 formation jointly, but it is also
Degrade its main peptase.Ang 1-7 have the function that anti-tissue fibrosis, and its mechanism is relevant with suppressing TGF-β path.It is slow to swash
The B2 receptor antagonists of peptide can weaken glomerulosclerosis and myocardial fibrosis, and its B1 acceptor gene knockout can mitigate kidney fibrous
Change, B1 receptor antagonists can improve glomerulonephritis, but bradykinin is main related to vessel retraction.
Although detecting that enkephalins increases in hyperplastic scar, it acts on the mainly itch with cicatricial tissue, pain
It is related etc. cacesthesia.Neurotensin is mainly distributed on brain and intestines and stomach, mainly to blood pressure control, stress, pain etc. it is related;
The peptide and its activator are possibly as potential tranquilizer, antalgesic and depressor.Other 3 kinds of active peptides also temporarily have no document report
Road is related to cicatrization, and wherein Chemotactic Peptide fMLF mainly plays the role of smooth muscle contraction, insulin B chain mainly with diabetes phase
Close, Ab1-40 and Ab1-42 are mainly related to the pathogenesis of alzheimer disease.
To sum up, this 5 ACE related activities peptides of Ang II, SP, AcSDKP, Ang 1-7 and bradykinin and its corresponding inhibitor
(including the antagonist of Ang II, SP and bradykinin, and AcSDKP, Ang 1-7 and ACE inhibitor) and fibrosis and scar
Formed related.According to literature query and our research, play facilitation is:Ang II, SP, AcSDKP inhibitor
(used in us is (that used in us is AcSDKP prolyl endopeptidase inhibitor S-17092), Ang 1-7 inhibitor
Ang 1-7 MAS acceptor inhibitor A779) and bradykinin;And play inhibitory action is ACEI (ACE Inhibitors, blood
Angiotensin converting enzyme inhibitor), ARB (Angiotensin Receptor Blocker, angiotensin-ii-receptor retardance
Agent), SP antagonist (that used in us is SP NK1 receptor antagonist L-733060), AcSDKP, Ang 1-7, bradykinin
Antagonist (that used in us is B1 receptor antagonist DALBK and B2 the receptor antagonist HOE-140 of bradykinin).
Wherein, ACEI and ARB has clinically been widely used in the treatment of hypertension.In addition, ACEI is also applied to control
Congestive heart failure, heart infarction, diabetic nephropathy and diabetes mellitus hypertension, high-risk-type angiocardiopathy etc. are treated, ARB can also be used for changing
Mercy declined, treatment after heart infarction, diabetic nephropathy, left ventricular hypertrophy, atrial fibrillation, metabolic syndrome and the clinics such as ACEI is cough caused are asked
Topic.Experimental study confirms that ACEI and ARB can be played in the pathologic processes such as Ventricular Remodeling, glomerulus fibrosis, pulmonary fibrosis
Improved effect.Although find that some ACE classes medicines have the function of suppressing fibrosis in experimental study, clinically not
Have maturation using ACE classes medicine as principle active component suppressing the medicine of cicatrization.
Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid etc. are mainly having for current clinical conventional anti-scar drug cream
Composition is imitated, suppresses cicatrization by different approaches.Hormone medicine (predominantly Triamcinolone acetonide) early in the sixties in 19th century just
By clinical practice in the treatment of scar, local injection hormone is the first-line treatment method of keloid at present, and Hypertrophic
The second line treatment method of scar, the effect that hormone suppresses scar proliferation mainly have benefited from its powerful anti-inflammatory, antipruritic and suppression carefully
Born of the same parents and the function of revascularization.Heparin plays the role of anti-inflammatory, antiallergy, suppression fibroblast proliferation and promotion organization hydration,
Collagen structure can be made to become loose;Contain substantial amounts of anti-inflammatory and polyphenoils in Bulbus Allii Cepae extract, there is in vitro study to show that onion carries
Take thing to reduce fibroblast proliferation, collagen formation and extracellular matrix to be formed;Contractubex is clinically commonly used at present i.e. simultaneously
Contain heparin and Bulbus Allii Cepae extract.Asiaticosid (Asiaticoside, asiaticoside, asiaticoside) is that the biology extracted from centella is living
Property material, have the function that promote Wound healing, reduce collagen I and collagen I II formation, and with anti-inflammatory function, be commonly used to
As wound or the auxiliary treatment of scar.
Oral method of administration can pass through the first pass effect of digestive system, and oral ARB and ACEI may have blood pressure reduction
Side effect, and oral hormone class medicine can cause Cushing syndrome etc., and the local drug concentration of scar also may not be high.It is transdermal
Medicine-feeding technology is that one kind improves the technology of Medicated Permeation by either physically or chemically, can effectively improve medicine local action
Depth, first pass effect of the digestive system to medicine is avoided, reduce medicine usage amount and reduce the adverse reaction of medicine.This patent leads to
Cross selection drug regimen and matched, prepare external preparation, above-mentioned anti-scar composition is preferably passed through keratoderma, arrive
Up to cicatricial tissue, acted synergistically by number of ways so as to preferably reach the purpose for suppressing cicatrix of skin and being formed.
The content of the invention
It is an object of the invention to provide a kind of anti-cicatrix externally used preparation of compound Angiotensin-Converting (ACE) class, it is used for
The treatment of cicatrix of skin, and with the ability for preferably penetrating skin barrier.The preparation is by one or more ACE classes medicines
(ACE related activities peptide and its corresponding inhibitor/antagonist) and other one or more anti-scarring drugs form for active principle.
The mass concentration of active ingredient (including ACE classes medicine and other anti-scarring drugs) is 0.05%-25% in preparation.The ACE
Class medicine refers to ARB (ARB), N- acetyl group-seryl-aspartoyl-lysyl-proline
(AcSDKP), hypertensin 1-7 (Ang 1-7), the antagonist L-733060 of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), the antagonist DALBK of bradykinin
With HOE-140 and angiotensin converting enzyme inhibitor (ACEI);Wherein, ARB is mainly selected from Losartan (Losartan), strategic point
Bei Shatan (Irb, Irbesartan), Valsartan (Valsartan), Telmisartan (Telmisartan), Olmesartan
(Olmesartan), Candesartan (Candesartan) etc.;ACEI is mainly selected from lisinopril (Lisinopril), Lei meter Pu
Sharp (Ramipril), captopril (Captopril), Cilazapril (Cilazapril), enalapril (Enalapril), shellfish
That Puli (Benazepril) etc..
Other anti-scarring drugs are from Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid etc..Said medicine is to face
Bed anti-scarring drug active ingredient, and medicine material is easily bought.
The mode of many of ACE classes effective ingredient combination is:1) ARB combines (quality proportioning 0.33- with ACEI
3:0.33-3;Combine reason:ARB can suppress this very strong scar proliferation factor of Ang II, but other active peptides can not be produced
Effect;Further suppress Ang II after adding ACEI, while AcSDKP and Ang 1-7 increase, the above is more beneficial for suppressing scar
Trace;But after adding ACEI, SP and bradykinin increase due to lacking ACE degraded, have cause becoming for scar proliferation in theory
Gesture);2) ARB and SP antagonist-combination (quality proportioning 0.33-3:0.33-3;Combine reason:The combination inhibits Ang II
The two very strong scar proliferation factors with SP, but other active peptides are not worked);3) ACEI and SP antagonist, slow swash
Antagonist-combination (the quality proportioning 0.33-3 of peptide:0.33-3:0.33-3;Combine reason:ACEI reduces Ang II, AcSDKP
Increase with Ang 1-7, the above is advantageous to suppress scar;But SP and bradykinin increase due to lacking ACE degraded, theoretical
On can cause scar proliferation, therefore add its antagonist and suppressed;All scar proliferation factors related such then ACE all obtain
Suppress);4) ARB combines SP antagonist, antagonist-combination (the quality proportioning 0.33-3 of bradykinin:0.33-3:0.33-3;
Combine reason:The combination inhibits the two very strong scar proliferation factors of Ang II, SP, and also inhibits bradykinin, this is stronger
Scar proliferation factor, but other active peptides are not worked);5) ARB combines SP antagonist, the antagonist of bradykinin, with
And AcSDKP, Ang 1-7 combination (quality proportioning 0.33-3:0.33-3:0.33-3:0.33-3:0.33-3;Combine reason:Should
Combination inhibit the two very strong scar proliferation factors of Ang II, SP, also inhibits this stronger scar proliferation of bradykinin because
Element, while increasing for AcSDKP and Ang 1-7 is also beneficial to suppress scar, all scar proliferation factors related so then ACE
All it is inhibited).Other combinations can suppress fibrosis and scar situation and principle (Fig. 1) according to ACE derive and
The selection of medicine.When several drugses combine, usually wait mass mixing, if necessary the quality of any component can on the quality such as be transferred to
When 3 times of highest or minimum 1/3 times when the quality such as being adjusted downward to.
The combination of active principles mode of other many of anti-scarring drugs is:1) Triamcinolone acetonide extracts with heparin, onion
Thing combines (quality proportioning 0.33-3:0.33-3:0.33-3;Combine reason:Anti-inflammatory, soften scar);2) Triamcinolone acetonide and product
Asiaticoside combines (quality proportioning 0.33-3:0.33-3;Combine reason:Anti-inflammatory, promote to repair);3) Bulbus Allii Cepae extract, heparin
(quality proportioning 0.33-3 is combined with asiaticosid:0.33-3:0.33-3;Combine reason:Anti-inflammatory, softening scar, promote to repair
It is multiple);4) Triamcinolone acetonide combines (quality proportioning 0.33-3 with Bulbus Allii Cepae extract, heparin and asiaticosid:0.33-3:0.33-3:
0.33-3;Triamcinolone acetonide has very strong antiinflammatory action after combining heparin and Bulbus Allii Cepae extract, while can soften scar and promotion
Repair);5) heparin combines (quality proportioning 0.33-3 with Bulbus Allii Cepae extract:0.33-3;Combine reason:Anti-inflammatory, softening scar).
Also other combinations can be selected according to action principle if necessary.When several drugses combine, mass mixing is usually waited, it is necessary former
The quality of one component can on 3 times of highest when the quality such as being transferred to or minimum 1/3 times when the quality such as being adjusted downward to.
The anti-cicatrix externally used preparation of compound ACE classes of the present invention, specific formulation can be solution (tincture and spirit), powder
Agent, lotion, liniment, finish, emulsion (containing creme), ointment (containing emulsifiable paste), paste, plaster, gel, plastics, aerosol (spray
Mist agent), emplastrum (rubber ointment, Babu plaster, bar cloth patch and other patches and paste etc.), other are (such as dissolved in diformazan
Formulation of base sulfoxide etc.).Active ingredient has bigger difference with specific formulation difference in preparation;Usual each component is all etc. that quality is mixed
Close, if necessary the quality of any of which component can on 3 times of highest when the quality such as being transferred to or minimum 1/ when the quality such as being adjusted downward to
3.Active ingredient is uniformly distributed in auxiliary element, i.e., in external preparation excipient, excipient may include adhesive, filler, collapse
Agent, lubricant, emulsifying agent, transdermal enhancer, preservative, aromatic, colouring agent etc. are solved, can be made by the selection and proportioning of excipient
Go out the external used medicine of different dosage forms and the optimum formula of certain formulation external used medicine;Auxiliary element can increase active ingredient and penetrate
The ability of skin barrier, and one or more of transdermal enhancers can be contained.
The present invention has advantages below:(1) ACE classes medicine has clinically had certain application, especially ACEI and ARB
Application it is very extensive, its security is self-evident, and its pharmacology, pharmacokinetics, toxicological study are fairly perfect.(2) Qu An
Nai De, heparin, Bulbus Allii Cepae extract, asiaticosid etc. have clinically been widely used, and its security and pharmaceutical research are
Through fairly perfect;(3) compared with clinically conventional single component steroids external application anti-scarring drug, compound ACE class medicines resist
Scar preparation can reduce the adverse reaction of hormone by not having to or reducing the hormone concentration in preparation;(4) with it is clinically normal
Silicone anti-scarring drug is compared, and invention formulation cost of material is very cheap, low manufacture cost, can greatly reduce patient
Financial burden, reduce treatment cost.(5) although the expression for reducing local T GF- β can improve cicatrization and know together, at present
The improvement scar medicine clinically applied with suppress inflammation (steroids, trade name " triamcinolone acetonide acetate urea cream " etc.),
Anti-inflammatory and softening scar (trade name " Contractubex " etc.), wound healing (trade name " asiaticoside frost " etc.), silica gel piece
(trade name " U.S. skin shield ", " celestial being card " etc.) and pressure therapy (Silica hydrogel pad pasting, trade name " easypro trace ", " easypro trace again ", " apply
Can answer " etc.) based on;Laboratory research have transfected using gene, antibody etc. reduces TGF-β, but temporarily has no matured product;Document
Confirm that ACE related activities peptide/inhibitor can influence the expression of TGF-β in vitro with our early-stage Study, partly have very well
Reduction TGF-β effect, the present invention is expected to fill up the market vacancy.(6) the anti-cicatrix externally used preparation of compound ACE classes has multiple
Pharmacological action, scar is acted synergistically on from multi-angle, play more preferable anti-scar effect;Meanwhile patient only needs to use one kind
Medicine, also can convenient use, increase compliance, so as to increase curative effect.
Brief description of the drawings
Fig. 1 is the metabolism of the fibrosis related activity peptide of Angiotensin-Converting (ACE) regulation and control.
Fig. 2 is the making of mouse back incisional scar model.
Fig. 3 is Ang II immunohistochemical experiment results, and K is ACE gene knockout groups, and R is Ramipril group, and H is that hydrazine benzene is rattled away
Piperazine low blood pressure control group, B are blank control group.
Fig. 4 is Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 immunohistochemical experiment result, and K is ACE gene knockout groups, and R is Ramipril group, and H is hydralazine
Low blood pressure control group, B are blank control group.
Fig. 5 is Ang 1-7 immunohistochemical experiment results, and K is ACE gene knockout groups, and R is Ramipril group, and H is that hydrazine benzene is rattled away
Piperazine low blood pressure control group, B are blank control group.
Fig. 6 is Angiotensin II, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, the average ash of hypertensin 1-7 that each group measures under ImageJ softwares
Spend (optical density) value.
Fig. 7 is concentration of the AcSDKP in cicatricial tissue, is from left to right ACE gene knockout groups, Ramipril group, hydrazine benzene
Pyridazine low blood pressure control group and blank control group.
Fig. 8 is NIH3T3 cells cell proliferative conditions under ACE related activities peptide or inhibitor effect.
Fig. 9 is that NIH3T3 cells collagen under ACE related activities peptide or inhibitor effect generates situation.
Embodiment
The present invention is further described in conjunction with the accompanying drawings and embodiments.The Bulbus Allii Cepae extract used in embodiment and centella
Glycosides etc. can be bought from medicine material company.
Embodiment 1 0.05% compound ACE classes medicine (0.03%ARB+0.02% triamcinolone acetonide acetates) anti-scar containing urea
The preparation of ointment
By taking Losartan Potassium+triamcinolone acetonide acetate as an example:By magnesium stearate 8.5g, white oil in 70 DEG C of waters bath with thermostatic control
34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;Distilled water is taken in 70 DEG C of waters bath with thermostatic control
32mL is added in 100ml beakers and is heated to 70 DEG C, is added urea 10g dissolvings and is used as aqueous phase;30mg chlorine is weighed with electronic balance
Husky smooth potassium and 20mg triamcinolone acetonide acetates, Losartan Potassium add aqueous phase dissolved, and triamcinolone acetonide acetate adds oil phase dissolving;Finally will
Aqueous phase oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.05% compound
ACE classes medicine (0.03%ARB+0.02% triamcinolone acetonide acetates) anti-scar ointment containing urea.
Ratio by changing Losartan Potassium, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point
Several compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
The system of embodiment 2 4% compound ACE classes medicine (1%ARB+3% triamcinolone acetonide acetates) anti-scar ointment containing urea
It is standby
By taking Valsartan+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g, white oil 34g,
Lanolin 14g is put into 100ml beakers, and heating is melted and stirred as oil phase;Distilled water 32mL is taken in 70 DEG C of waters bath with thermostatic control
Add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With electronic balance weigh 1g Valsartans and
3g triamcinolone acetonide acetates, Valsartan add aqueous phase dissolved, and triamcinolone acetonide acetate adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred
And add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 4% compound ACE class medicines
The preparation of (1%ARB+3% triamcinolone acetonide acetates) anti-scar ointment containing urea.
0.05-25% mass fractions can be obtained by the ratio for changing Valsartan, triamcinolone acetonide acetate and ointment bases
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
Embodiment 3 5% compound ACE classes medicine (2%ARB+3% triamcinolone acetonide acetates) anti-scar containing numerous emulsifiers is soft
The preparation of cream
By taking Irbesartan+triamcinolone acetonide acetate as an example:By stearic acid 4.8g, octadecyl alcolol 4g, list in 70 DEG C of waters bath with thermostatic control
Tristerin 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating and melting and the conduct that stirs
Oil phase;Take distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to add
Heat is to 70 DEG C and well mixed is used as aqueous phase;2g Irbesartans and 3g triamcinolone acetonide acetates, Irbesartan are weighed with electronic balance
Aqueous phase dissolved is added, triamcinolone acetonide acetate adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature,
It is sealed in 5 DEG C of refrigerators.Above method obtains 5% compound ACE classes medicine (2%ARB+3% triamcinolone acetonide acetates) containing more
The kind anti-scar ointment of emulsifying agent.
Ratio by changing Irbesartan, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point
Several compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
Embodiment 4 3% compound ACE classes medicine (2%ARB+1% triamcinolone acetonide acetates) anti-scar normal saline solution
Prepare
By taking Losartan Potassium+triamcinolone acetonide acetate as an example:Under room temperature condition, 100g normal saline solutions are weighed, with electronics day
Flat weigh is sufficiently stirred in 2g Losartan Potassiums and 1g triamcinolone acetonide acetates addition physiological saline.Encapsulation preserves.Above method obtains
3% compound ACE classes medicine (2%ARB+1% triamcinolone acetonide acetates) anti-scar normal saline solution.
0.05-25% concentration is can obtain by changing physiological saline and Losartan Potassium, triamcinolone acetonide acetate quality proportioning
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar normal saline solution, with for different type scar or obtain most
Good anti-scar effect.
The preparation of embodiment 5 20% compound ACE classes medicine (15%ARB+5% triamcinolone acetonide acetates) anti-scar gel
By taking Irbesartan+triamcinolone acetonide acetate as an example:Under room temperature condition, 72g normal saline solutions are weighed, add 15g strategic points
Bei Shatan and 5g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.Finally
Add 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 0.2% compound ACE classes medicine (15%ARB+5% acetic acid
Triamcinolone acetonide) anti-scar gel.
0.05-25% concentration is can obtain by changing physiological saline and Irbesartan, the quality proportioning of triamcinolone acetonide acetate
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar gel, for different type scar or to obtain optimal anti-scar
Trace effect.
Embodiment 6 15% compound ACE classes medicine (5%ARB+10% triamcinolone acetonide acetates) anti-scar plastics preparation side
Method
By taking Valsartan+triamcinolone acetonide acetate as an example:Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, 90
It is stirred well to and is completely dissolved in DEG C water bath with thermostatic control, add 3ml glycerine, stirs to well mixed.It is eventually adding 5g Valsartans
With 10g triamcinolone acetonide acetates, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
0.05-25% concentration is can obtain by changing plastics matrix and Valsartan, the quality proportioning of triamcinolone acetonide acetate
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar plastics, for different type scar or to obtain optimal anti-
Scar effect.
The anti-scar bar cloth patch preparation method of the compound ACE classes medicine (6%ARB+2% triamcinolone acetonide acetates) of embodiment 7 8%
By taking Telmisartan+triamcinolone acetonide acetate as an example:In 50 DEG C of waters bath with thermostatic control, 6g Telmisartans and 2g acetic acid Qu An are taken
Nai De, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums,
0.1gEDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally
A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With
Upper method obtains the anti-scar bar cloth patch of 8% compound ACE classes medicine (6%ARB+2% triamcinolone acetonide acetates).
By changing, bar cloth pastes matrix and a Telmisartan, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense
The anti-scar bar cloth patch of compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) of degree, with optimal for different type scar or acquirement
Anti- scar effect.
Embodiment 8 4% compound ACE classes medicine (3%ARB+1% triamcinolone acetonide acetates) anti-scar spray preparation method
By taking Losartan Potassium+triamcinolone acetonide acetate as an example:In 100g physiological saline, add 3g Losartan Potassiums and 1g acetic acid is bent
An Naide and 1g urea, is stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Losartan Potassium, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar spray of degree, with optimal for different type scar or acquirement
Anti- scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1%) of embodiment 9 3% contains urea
The preparation of anti-scar ointment
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:By magnesium stearate in 70 DEG C of waters bath with thermostatic control
8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of thermostatted waters
Take distilled water 32mL to add in 100ml beakers in bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With electronics day
Flat to weigh 1g Losartan Potassiums, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, Losartan Potassium adds aqueous phase dissolved, and how is acetic acid Qu An
Moral, Bulbus Allii Cepae extract add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5
In DEG C refrigerator.Above method obtains 3% compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1%) and contained
The anti-scar ointment of urea.
It can be obtained by the ratio for changing Losartan Potassium, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft
Cream.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 3%ARB+1% triamcinolone acetonide acetates+1%) of embodiment 10 5% contains urea
The preparation of anti-scar ointment
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g,
White oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;In 70 DEG C of waters bath with thermostatic control
Take distilled water 32mL to add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Claimed with electronic balance
3g Valsartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates are taken, Valsartan adds aqueous phase dissolved, triamcinolone acetonide acetate, onion
Extract adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5
In DEG C refrigerator.Above method obtains 5% compound ACE classes medicine (Bulbus Allii Cepae extract of 3%ARB+1% triamcinolone acetonide acetates+1%) and contained
The anti-scar ointment of urea.
0.05- can be obtained by the ratio for changing Valsartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar ointment containing urea of 25% mass fraction.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 10%ARB+10% triamcinolone acetonide acetates+5%) of embodiment 11 25% contains
The preparation of the anti-scar ointment of numerous emulsifiers
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 70 DEG C of waters bath with thermostatic control by stearic acid 4.8g,
Octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting is simultaneously
Stir as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add in 70 DEG C of waters bath with thermostatic control
It is heated to 70 DEG C in 100ml beakers and is well mixed to be used as aqueous phase;10g Irbesartans are weighed with electronic balance, 10g onions are extracted
Thing and 5g triamcinolone acetonide acetates, Irbesartan add aqueous phase dissolved, and triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving;
Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 25%
Square ACE classes medicine (Bulbus Allii Cepae extract of 10%ARB+10% triamcinolone acetonide acetates+5%) anti-scar ointment containing numerous emulsifiers.
It can be obtained by the ratio for changing Irbesartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft
Cream.
Embodiment 12 10% compound ACE classes medicine (Bulbus Allii Cepae extract of 6%ARB+2% triamcinolone acetonide acetates+1%) anti-scar
The preparation of trace normal saline solution
By taking Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Under room temperature condition, it is water-soluble to weigh 100g physiology salts
Liquid, weighed in 6g Telmisartans, 2g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates addition physiological saline with electronic balance and fully stirred
Mix.Encapsulation preserves.Above method obtains 10% compound ACE classes medicine, and (onion of 6%ARB+2% triamcinolone acetonide acetates+1% is extracted
Thing) anti-scar normal saline solution.
By changing physiological saline and Telmisartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract quality proportioning can obtain
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar normal saline solution of 0.05-25% concentration,
With for different type scar or the optimal anti-scar effect of acquirement.
Embodiment 13 25% compound ACE classes medicine (Bulbus Allii Cepae extract of 15%ARB+5% triamcinolone acetonide acetates+5%) anti-scar
The preparation of trace gel
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Under room temperature condition, it is water-soluble to weigh 72g physiology salts
Liquid, add 15g Losartan Potassiums, 5g Bulbus Allii Cepae extracts and 5g triamcinolone acetonide acetates and fully dissolve, add 3g carboxymethyl celluloses
Sodium, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 25% compound
ACE classes medicine (Bulbus Allii Cepae extract of 15%ARB+5% triamcinolone acetonide acetates+5%) anti-scar gel.
By changing physiological saline and Losartan Potassium, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar gel of 0.05-25% concentration, with for not
Same type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 14 0.3% (extract by the onion of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%
Thing) anti-scar plastics preparation method
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml steamings
In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally plus
Enter 100mg Valsartans, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, be stirred well to and be completely dissolved, be cooled to room
Temperature.Encapsulation preserves.
By changing plastics matrix and Valsartan, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain
Compound ACE classes medicine (Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics of 0.05-25% concentration, with pin
To different type scar or obtain optimal anti-scar effect.
Embodiment 15 4% compound ACE classes medicine (Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1%) anti-scar
Ba Bu pastes preparation method
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 50 DEG C of waters bath with thermostatic control, take 2g Irbesartans,
1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, are dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine,
2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving is stirred
Mix uniformly, obtain B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with,
Cover adherent layer, stripping and slicing.Above method obtains 4% compound ACE classes medicine, and (onion of 2%ARB+1% triamcinolone acetonide acetates+1% carries
Take thing) anti-scar bar cloth patch.
The quality proportioning that matrix and Irbesartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract are pasted by changing bar cloth can obtain
The anti-scar bar cloth patch of the compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% concentration, with for
Different type scar obtains optimal anti-scar effect.
Embodiment 16 18% compound ACE classes medicine (Bulbus Allii Cepae extract of 10%ARB+4% triamcinolone acetonide acetates+4%) anti-scar
Trace spray preparation method
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 100g physiological saline, 10g Losartans are added
Potassium, 4g Bulbus Allii Cepae extracts and 4g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Losartan Potassium, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain
Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar spray of 0.05-25% concentration, with for
Different type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% of embodiment 17 5%
Plain sodium) the anti-scar ointment containing urea preparation
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:By stearic acid in 70 DEG C of waters bath with thermostatic control
Magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of constant temperature
Take distilled water 32mL to add in 100ml beakers in water-bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Use electronics
Balance weighs 2g Valsartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins, and Losartan Potassium adds aqueous phase dissolved,
Triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to
Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtain 5% compound ACE classes medicine (2%ARB+1% triamcinolone acetonide acetates+
The liquaemin of 1% Bulbus Allii Cepae extract+1%) the anti-scar ointment containing urea.
It can be obtained by the ratio for changing Valsartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) for obtaining 0.05-25% mass fractions contains urea
Anti- scar ointment.
The compound ACE classes medicine of embodiment 18 0.4% (extract by the onion of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%
The liquaemin of thing+0.1%) the anti-scar ointment containing urea preparation
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of perseverances
Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Electricity consumption
Sub- balance weighs 100mg Irbesartans, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, E Beisha
Tanga enters aqueous phase dissolved, and triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;The mixing of water oil phase is sufficiently stirred
And add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE class medicines
Thing (liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%) anti-scar ointment containing urea.
Can be with by the ratio for changing Irbesartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine
The anti-scar ointment of element.
The compound ACE classes medicine (liver of+3% Bulbus Allii Cepae extract of 1%ARB+3% triamcinolone acetonide acetates+3% of embodiment 19 10%
Plain sodium) the anti-scar ointment containing numerous emulsifiers preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating
Melt and stir as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g are taken in 70 DEG C of waters bath with thermostatic control
Add in 100ml beakers and be heated to 70 DEG C and be well mixed to be used as aqueous phase;1g Losartan Potassiums are weighed with electronic balance, 3g onions carry
Thing, 3g triamcinolone acetonide acetates and 3g liquaemins are taken, Losartan Potassium adds aqueous phase dissolved, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
Plain sodium adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.
Above method obtains 10% compound ACE classes medicine (liquaemin of+3% Bulbus Allii Cepae extract of 1%ARB+3% triamcinolone acetonide acetates+3%)
Containing the anti-scar ointment of numerous emulsifiers.
Can be with by the ratio for changing Losartan Potassium, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine
The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 20 3% (Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+0.5%+
0.5% liquaemin) anti-scar normal saline solution preparation
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Under room temperature condition, 100g physiology salts are weighed
The aqueous solution, weigh 1g Valsartans, 1g Bulbus Allii Cepae extracts, 0.5g triamcinolone acetonide acetates and 0.5g liquaemins with electronic balance and add life
It is sufficiently stirred in reason salt solution.Encapsulation preserves.Above method obtains 3% compound ACE classes medicine (1%ARB+1% triamcinolone acetonide acetates
The liquaemin of+0.5% Bulbus Allii Cepae extract+0.5%) anti-scar normal saline solution.
It can be obtained by changing physiological saline and Valsartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract quality proportioning
To compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar physiology of 0.05-25% concentration
Saline solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 3%ARB+3% triamcinolone acetonide acetates+3% of embodiment 21 10%
Plain sodium) anti-scar gel preparation
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Under room temperature condition, 72g physiology is weighed
Saline solution, add 3g Irbesartans, 1g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 3g liquaemins and fully dissolve, add
3g sodium carboxymethylcelluloses, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With top
Method obtains 10% compound ACE classes medicine (liquaemin of+1 Bulbus Allii Cepae extract of 3%ARB+3% triamcinolone acetonide acetates+3%) anti-scar and coagulated
Glue.
By changing physiological saline and Irbesartan, triamcinolone acetonide acetate, liquaemin and the quality proportioning of Bulbus Allii Cepae extract
It can obtain compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar of 0.05-25% concentration
Gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1% of embodiment 22 4%
Plain sodium) anti-scar plastics preparation method
By taking Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Weigh 8g polyvinyl alcohol (PVA) addition
Into 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirring is equal to mixing
It is even.1g Telmisartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins are eventually adding, is stirred well to completely molten
Solution, is cooled to room temperature.Encapsulation preserves.
Matched somebody with somebody by the quality for changing plastics matrix and Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract
Than compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration
Trace plastics, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ARB+3% triamcinolone acetonide acetates+2% of embodiment 23 9%
Plain sodium) anti-scar bar cloth patch preparation method
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 50 DEG C of waters bath with thermostatic control, 2g chlorine is taken
Husky smooth potassium, 2g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 2g liquaemins, are dissolved in 80g distilled water, are added into the aqueous solution
2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added
Into 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room
Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 9% compound ACE classes medicine (2%ARB+3% acetic acid
The liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+2%+2%) anti-scar bar cloth patch.
The quality that matrix and Losartan Potassium, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract are pasted by changing bar cloth is matched somebody with somebody
Than compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration
Trace bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% of embodiment 24 5%
Plain sodium) anti-scar spray preparation method
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 100g physiological saline, 2g figured silk fabrics is added
Sha Tan, 1g Bulbus Allii Cepae extract, 1g triamcinolone acetonide acetates and 1g liquaemins and 1g urea, are stirred.And load spray bottle
In.
By changing spray reclaimed water and Valsartan, triamcinolone acetonide acetate, liquaemin and the quality proportioning of Bulbus Allii Cepae extract
It can obtain compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar of 0.05-25% concentration
Spray, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1% of embodiment 25 6%
The plain asiaticosid of sodium+1%) the anti-scar ointment containing urea preparation
By taking smooth potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid for rice as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;1g, which is weighed, with electronic balance replaces the smooth potassium of rice, 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g liquaemins and 1g centellas
Glycosides, aqueous phase dissolved is added for the smooth potassium of rice, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;
Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 6%
Square ACE classes medicine (asiaticosid of+1% liquaemin of+2% Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1%) contains urea
Anti- scar ointment.
By changing Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases
Ratio can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% mass fractions
Sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (liver of+3% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% of embodiment 26 8%
The plain asiaticosid of sodium+1%) the anti-scar ointment containing urea preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;2g Losartan Potassiums, 3g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetate 1g asiaticosids and 1g heparin are weighed with electronic balance
Sodium, Losartan Potassium add aqueous phase dissolved, and triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;
The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains
To the 8% compound ACE classes medicine (centella of+1% liquaemin of+3% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1%
Glycosides) the anti-scar ointment containing urea.
By changing Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases
Ratio can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% mass fractions
Sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (onion of+0.1% triamcinolone acetonide acetate of 0.1% Losartan Potassium+0.1% of embodiment 27 0.5%
The asiaticosid of the liquaemin of extract+0.1%+0.1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 70 DEG C of waters bath with thermostatic control
It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml
Beaker, heating and melting simultaneously stir as oil phase;Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control
Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;100mg chlorine sand is weighed with electronic balance
Smooth potassium, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg asiaticosids and 100mg liquaemins, Losartan Potassium add
Enter aqueous phase dissolved, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;Finally by aqueous phase oil
Mix and be sufficiently stirred and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE class medicines
(asiaticosid of+0.1% liquaemin of 0.1% Losartan Potassium+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) contains
The anti-scar ointment of numerous emulsifiers.
By changing Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases
Ratio can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% mass fractions
Sodium+asiaticosid) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 28 0.5% (extract by the onion of 0.1%ARB+0.2% triamcinolone acetonide acetates+0.1%
The asiaticosid of the liquaemin of thing+0.05%+0.05%) anti-scar normal saline solution preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Under room temperature condition, claim
100g normal saline solutions are taken, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts, 200mg acetic acid Qu An are weighed with electronic balance
Nai De, 50mg asiaticosid and 50mg liquaemins, which are added in physiological saline, to be sufficiently stirred.Encapsulation preserves.Above method obtains
0.5% compound ACE classes medicine (liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ARB+0.2% triamcinolone acetonide acetates+0.05%+
0.05% asiaticosid) anti-scar normal saline solution.
By changing physiological saline and Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid matter
Amount proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin+
Asiaticosid) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ARB+2% triamcinolone acetonide acetates+2% of embodiment 29 10%
The plain asiaticosid of sodium+2%) anti-scar gel preparation
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Under room temperature condition, weigh
72g normal saline solutions, add 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins
Fully dissolving, 3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fat
Sour sorb is smooth.Above method obtain 10% compound ACE classes medicine (Bulbus Allii Cepae extract of 2%ARB+2% triamcinolone acetonide acetates+2%+
The asiaticosid of 2% liquaemin+2%) anti-scar gel.
By changing physiological saline and Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and the matter of asiaticosid
Amount proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin+
Asiaticosid) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 6%ARB+2% triamcinolone acetonide acetates+2% of embodiment 30 14%
The plain asiaticosid of sodium+2%) anti-scar plastics preparation method
By taking Telmisartan as an example:Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, in 90 DEG C of waters bath with thermostatic control
It is stirred well to and is completely dissolved, add 3ml glycerine, stirs to well mixed.It is eventually adding 6g Telmisartans, the extraction of 2g onions
Thing, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation is protected
Deposit.
By changing plastics matrix and Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid
Quality proportioning can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration
Sodium+asiaticosid) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+0.5% of 3%ARB+2% triamcinolone acetonide acetates+3% of embodiment 31 9%
The asiaticosid of liquaemin+0.5%) anti-scar bar cloth patch preparation method
By taking Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 50 DEG C of waters bath with thermostatic control
In, the smooth potassium of 3g candys, 3g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 500mg asiaticosids and 500mg liquaemins are taken, is dissolved in
In 80g distilled water, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution,
Obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed simultaneously
It is stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 9%
Compound ACE classes medicine (asiaticosid of+0.5% liquaemin of+3% Bulbus Allii Cepae extract of 3%ARB+2% triamcinolone acetonide acetates+0.5%)
Anti- scar bar cloth patch.
Matrix and the smooth potassium of candy, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid are pasted by changing bar cloth
Quality proportioning can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration
Sodium+asiaticosid) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 2%ARB+3% triamcinolone acetonide acetates+1% of embodiment 32 8%
The plain asiaticosid of sodium+1%) anti-scar spray preparation method
By taking Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 100g physiological saline
In, 2g Telmisartans, 1g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins and 1g urea are added, is filled
Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and for the smooth potassium of rice, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid
Quality proportioning can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration
Sodium+asiaticosid) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
Embodiment 33 0.05% compound ACE classes medicine (0.02%ACEI+0.03% triamcinolone acetonide acetates) anti-scar containing urea
The preparation of trace ointment
By taking Ramipril+triamcinolone acetonide acetate as an example:By magnesium stearate 8.5g, white oil in 70 DEG C of waters bath with thermostatic control
34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;Distilled water is taken in 70 DEG C of waters bath with thermostatic control
32mL is added in 100ml beakers and is heated to 70 DEG C, is added urea 10g dissolvings and is used as aqueous phase;20mg thunders are weighed with electronic balance
Meter Pu Li and 30mg triamcinolone acetonide acetates, Ramipril, triamcinolone acetonide acetate add oil phase dissolving;Finally aqueous phase oil phase is mixed
And be sufficiently stirred and be cooled to room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 0.05% compound ACE class medicines
(0.02%ACEI+0.03% triamcinolone acetonide acetates) anti-scar ointment containing urea.
Ratio by changing Ramipril, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point
Several compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
Embodiment 34 0.3% compound ACE classes medicine (0.2%ACEI+0.1% triamcinolone acetonide acetates) anti-scar containing urea
The preparation of ointment
By taking enalapril+triamcinolone acetonide acetate as an example:By magnesium stearate 8.5g, white oil in 70 DEG C of waters bath with thermostatic control
34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;Distilled water is taken in 70 DEG C of waters bath with thermostatic control
32mL is added in 100ml beakers and is heated to 70 DEG C, is added urea 10g dissolvings and is used as aqueous phase;With electronic balance weigh 200m according to
That Puli and 100mg triamcinolone acetonide acetates, enalapril, triamcinolone acetonide acetate add oil phase dissolving;The mixing of water oil phase is fully stirred
Mix and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 0.3% compound ACE classes
Medicine (0.2%ACEI+0.1% triamcinolone acetonide acetates) anti-scar ointment containing urea.
Ratio by changing enalapril, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point
Several compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
The compound ACE classes medicine (0.9%ACEI+0.3% triamcinolone acetonide acetates) of embodiment 35 1.2% contains numerous emulsifiers
The preparation of anti-scar ointment
By taking captopril+triamcinolone acetonide acetate as an example:By stearic acid 4.8g, octadecyl alcolol 4g, list in 70 DEG C of waters bath with thermostatic control
Tristerin 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating and melting and the conduct that stirs
Oil phase;Take distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to add
Heat is to 70 DEG C and well mixed is used as aqueous phase;900mg captoprils and 300mg triamcinolone acetonide acetates are weighed with electronic balance, is blocked
Top's profit, triamcinolone acetonide acetate add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, sealing is protected
It is stored in 5 DEG C of refrigerators.Above method obtains 1.2% compound ACE classes medicine (0.9%ACEI+0.3% triamcinolone acetonide acetates) containing more
The kind anti-scar ointment of emulsifying agent.
Ratio by changing captopril, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point
Several compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar ointment containing numerous emulsifiers.
Embodiment 36 5% compound ACE classes medicine (3%ACEI+2% triamcinolone acetonide acetates) anti-scar normal saline solution
Preparation
By taking Ramipril+triamcinolone acetonide acetate as an example:Under room temperature condition, 100g normal saline solutions are weighed, with electronics day
Flat weigh is sufficiently stirred in 3g Ramiprils and 2g triamcinolone acetonide acetates addition physiological saline.Encapsulation preserves.Above method obtains
5% compound ACE classes medicine (triamcinolone acetonide acetate of 3% Ramipril+2%) anti-scar normal saline solution.
0.05-25% concentration is can obtain by changing physiological saline and Ramipril, triamcinolone acetonide acetate quality proportioning
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar normal saline solution, with for different type scar or obtain most
Good anti-scar effect.
The preparation of embodiment 37 10% compound ACE classes medicine (5%ACEI+5% triamcinolone acetonide acetates) anti-scar gel
By taking enalapril+triamcinolone acetonide acetate as an example:Under room temperature condition, 72g normal saline solutions are weighed, add 5g according to that
Puli and 5g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.Finally plus
Enter 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 10% compound ACE classes medicine, and (5%ACEI+5% acetic acid is bent
An Naide) anti-scar gel.
0.05-25% concentration is can obtain by changing physiological saline and enalapril, the quality proportioning of triamcinolone acetonide acetate
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar gel, for different type scar or to obtain optimal anti-scar
Trace effect.
It is prepared by the anti-scar plastics of the compound ACE classes medicine (5%ACEI+10% triamcinolone acetonide acetates) of embodiment 38 15%
Method
By taking lisinopril+triamcinolone acetonide acetate as an example:8g polyvinyl alcohol (PVA) is weighed to be added in 88ml distilled water,
It is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.It is eventually adding 5g and relies promise
Puli and 10g triamcinolone acetonide acetates, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and lisinopril, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar plastics of degree, with optimal for different type scar or acquirement
Anti- scar effect.
The anti-scar bar cloth patch of the compound ACE classes medicine (0.1%ACEI+0.2% triamcinolone acetonide acetates) of embodiment 39 0.3%
Preparation method
By taking Ramipril+triamcinolone acetonide acetate as an example:In 50 DEG C of waters bath with thermostatic control, 100mg Ramiprils and 200mg vinegar are taken
Sour Triamcinolone acetonide, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums,
0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally
A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With
Upper method obtains the anti-scar bar cloth patch of 0.3% compound ACE classes medicine (0.1%ACEI+0.2% triamcinolone acetonide acetates).
By changing, bar cloth pastes matrix and a Ramipril, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense
The anti-scar bar cloth patch of compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) of degree, with optimal for different type scar or acquirement
Anti- scar effect.
Embodiment 40 0.8% compound ACE classes medicine (0.2%ACEI+0.6% triamcinolone acetonide acetates) anti-scar spray
Preparation method
By taking enalapril+triamcinolone acetonide acetate as an example:In 100g physiological saline, 200mg enalaprils and 600mg are added
Triamcinolone acetonide acetate and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and enalapril, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar spray of degree, with optimal for different type scar or acquirement
Anti- scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+1% triamcinolone acetonide acetates+1%) of embodiment 41 3% is containing urine
The preparation of the anti-scar ointment of element
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:By magnesium stearate in 70 DEG C of waters bath with thermostatic control
8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of thermostatted waters
Take distilled water 32mL to add in 100ml beakers in bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With electronics day
It is flat to weigh 1g captoprils, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, captopril, triamcinolone acetonide acetate, onion extraction
Thing adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.With
Upper method obtains 3% compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+1% triamcinolone acetonide acetates+1%) anti-scar containing urea
Ointment.
It can be obtained by the ratio for changing captopril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft
Cream.
The compound ACE classes medicine of embodiment 42 1% (extract by the onion of 0.3%ACEI+0.5% triamcinolone acetonide acetates+0.2%
Thing) the anti-scar ointment containing urea preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:By magnesium stearate in 70 DEG C of waters bath with thermostatic control
8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of thermostatted waters
Take distilled water 32mL to add in 100ml beakers in bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With electronics day
It is flat to weigh 300mg Ramiprils, 200mg Bulbus Allii Cepae extracts and 500mg triamcinolone acetonide acetates, Ramipril, triamcinolone acetonide acetate,
Bulbus Allii Cepae extract adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealing is deposited
It is stored in 5 DEG C of refrigerators.Above method obtains 1% compound ACE classes medicine (0.3%ACEI+0.5% triamcinolone acetonide acetates+0.2%
Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
It can be obtained by the ratio for changing Ramipril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft
Cream.
The compound ACE classes medicine of embodiment 43 0.5% (extract by the onion of 0.3%ACEI+0.1% triamcinolone acetonide acetates+0.1%
Thing) the anti-scar ointment containing numerous emulsifiers preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 70 DEG C of waters bath with thermostatic control by stearic acid 4.8g,
Octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting is simultaneously
Stir as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add in 70 DEG C of waters bath with thermostatic control
It is heated to 70 DEG C in 100ml beakers and is well mixed to be used as aqueous phase;300mg enalaprils, 100mg onions are weighed with electronic balance
Extract and 100mg triamcinolone acetonide acetates, enalapril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving;Finally will
Aqueous phase oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE
Class medicine (Bulbus Allii Cepae extract of 0.3%ACEI+0.1% triamcinolone acetonide acetates+0.1%) anti-scar ointment containing numerous emulsifiers.
It can be obtained by the ratio for changing enalapril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions resists containing numerous emulsifiers
Scar ointment.
Embodiment 44 4% compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+1%) anti-scar
The preparation of trace normal saline solution
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Under room temperature condition, it is water-soluble to weigh 100g physiology salts
Liquid, weighed in 1g captoprils, 1g Bulbus Allii Cepae extracts and 2g triamcinolone acetonide acetates addition physiological saline with electronic balance and fully stirred
Mix.Encapsulation preserves.Above method obtains 4% compound ACE classes medicine, and (onion of 1%ACEI+2% triamcinolone acetonide acetates+1% is extracted
Thing) anti-scar normal saline solution.
By changing physiological saline and captopril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract quality proportioning can obtain
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar normal saline solution of 0.05-25% concentration,
With for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 45 1.1% (extract by the onion of 0.3%ACEI+0.2% triamcinolone acetonide acetates+0.6%
Thing) anti-scar gel preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Under room temperature condition, it is water-soluble to weigh 72g physiology salts
Liquid, add 300mg Ramiprils, 600mg Bulbus Allii Cepae extracts and 200mg triamcinolone acetonide acetates and fully dissolve, add 3g carboxylic first
Base sodium cellulosate, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains
1% compound ACE classes medicine (Bulbus Allii Cepae extract of 0.3%ACEI+0.2% triamcinolone acetonide acetates+0.6%) anti-scar gel.
By changing physiological saline and Ramipril, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar gel of 0.05-25% concentration, with for not
Same type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 46 0.3% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1%
Thing) anti-scar plastics preparation method
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml
In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally
100mg captoprils, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates are added, is stirred well to and is completely dissolved, is cooled down
To room temperature.Encapsulation preserves.
By changing plastics matrix and captopril, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain
Compound ACE classes medicine (captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics of 0.05-25% concentration, with
For different type scar or obtain optimal anti-scar effect.
Embodiment 47 15% compound ACE classes medicine (Bulbus Allii Cepae extract of 9%ACEI+3% triamcinolone acetonide acetates+3%) anti-scar
Trace bar cloth pastes preparation method
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 50 DEG C of waters bath with thermostatic control, take 9g lisinoprils,
3g Bulbus Allii Cepae extracts and 3g triamcinolone acetonide acetates, are dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine,
2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving is stirred
Mix uniformly, obtain B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with,
Cover adherent layer, stripping and slicing.Above method obtains the 15% compound ACE classes medicine (onion of 9%ACEI+3% triamcinolone acetonide acetates+3%
Extract) anti-scar bar cloth patch.
The quality proportioning that matrix and lisinopril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract are pasted by changing bar cloth can obtain
The anti-scar bar cloth patch of the compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% concentration, with for
Different type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+0.5%) of embodiment 48 2%
Anti- scar spray preparation method
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 100g physiological saline, 1g Lei meter Pu are added
Profit, 500mg Bulbus Allii Cepae extracts and 500mg triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain
Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar spray of 0.05-25% concentration, with for
Different type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 49 0.5% (extract by the onion of 0.1%ACEI+0.2% triamcinolone acetonide acetates+0.1%
The liquaemin of thing+0.1) the anti-scar ointment containing urea preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of perseverances
Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Electricity consumption
Sub- balance weighs 100mg enalaprils, 100mg Bulbus Allii Cepae extracts, 200mg triamcinolone acetonide acetates and 100mg liquaemins, Yi Napu
Profit, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred cold
But to room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE classes medicine (0.1%ACEI+0.2% vinegar
The sour liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+0.1%+0.1%) the anti-scar ointment containing urea.
Can be with by the ratio for changing enalapril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine
The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 50 3% (Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+0.5%+
1% liquaemin) the anti-scar ointment containing urea preparation
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of perseverances
Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Electricity consumption
Sub- balance weighs 1g lisinoprils, 500mg Bulbus Allii Cepae extracts, 500mg triamcinolone acetonide acetates and 1g liquaemins, lisinopril, vinegar
Sour Triamcinolone acetonide, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue
Stir to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 3% compound ACE classes medicine (1%ACEI+0.5% acetic acid
The liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+0.5%+1%) the anti-scar ointment containing urea.
Can be with by the ratio for changing lisinopril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine
The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 51 0.9% (extract by the onion of 0.1%ACEI+0.2% triamcinolone acetonide acetates+0.3%
The liquaemin of thing+0.3%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating
Melt and stir as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g are taken in 70 DEG C of waters bath with thermostatic control
Add in 100ml beakers and be heated to 70 DEG C and be well mixed to be used as aqueous phase;100mg Ramiprils, 300mg are weighed with electronic balance
Bulbus Allii Cepae extract, 200mg triamcinolone acetonide acetates and 300mg liquaemins, Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
Plain sodium adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.
Above method obtain 0.9% compound ACE classes medicine (Bulbus Allii Cepae extract of 0.1%ACEI+0.2% triamcinolone acetonide acetates+0.3%+
0.3% liquaemin) the anti-scar ointment containing numerous emulsifiers.
Can be with by the ratio for changing Ramipril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine
The anti-scar ointment of element.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+1% of embodiment 52 5%
Plain sodium) anti-scar normal saline solution preparation
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Under room temperature condition, 100g physiology is weighed
Saline solution, weigh 1g captoprils, 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins with electronic balance and add life
It is sufficiently stirred in reason salt solution.Encapsulation preserves.Above method obtains 5% compound ACE classes medicine, and (how is 1%ACEI+2% acetic acid Qu An
The liquaemin of the Bulbus Allii Cepae extract of moral+1%+1%) anti-scar normal saline solution.
Can by changing physiological saline and captopril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract quality proportioning
Obtain the anti-scar life of compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% concentration
Saline solution is managed, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ACEI+2% triamcinolone acetonide acetates+1% of embodiment 53 7%
Plain sodium) anti-scar gel preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Under room temperature condition, 72g physiology is weighed
Saline solution, add 2g enalaprils, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins and fully dissolve, add
3g sodium carboxymethylcelluloses, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With top
Method obtains 7% compound ACE classes medicine (liquaemin of+2% Bulbus Allii Cepae extract of 2%ACEI+2% triamcinolone acetonide acetates+1%) anti-scar
Gel.
By changing physiological saline and enalapril, triamcinolone acetonide acetate, liquaemin and the quality proportioning of Bulbus Allii Cepae extract
It can obtain compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar of 0.05-25% concentration
Gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 54 3% (Bulbus Allii Cepae extract of 0.5%ACEI+0.5% triamcinolone acetonide acetates+1%+
1% liquaemin) anti-scar plastics preparation method
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Weigh 8g polyvinyl alcohol (PVA) addition
Into 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirring is equal to mixing
It is even.500mg lisinoprils, 1g Bulbus Allii Cepae extracts, 500mg triamcinolone acetonide acetates and 1g liquaemins are eventually adding, is stirred well to
It is completely dissolved, is cooled to room temperature.Encapsulation preserves.
Matched somebody with somebody by the quality for changing plastics matrix and lisinopril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract
Than compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration
Trace plastics, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 55 0.4% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1%
The liquaemin of thing+0.1%) anti-scar bar cloth patch preparation method
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 50 DEG C of waters bath with thermostatic control, take
100mg enalaprils, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, are dissolved in 80g distilled water,
2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid;Separately take
4g Sodium Polyacrylates, add in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and is stirred well to mixed
Close uniformly, be cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 0.4% compound ACE class medicines
The anti-scar bar cloth patch of thing (liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate of 0.1% enalapril+0.1%).
The quality that matrix and enalapril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract are pasted by changing bar cloth is matched somebody with somebody
Than compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration
Trace bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (Bulbus Allii Cepae extract+3% of 1%ACEI+3% triamcinolone acetonide acetates+3% of embodiment 56 10%
Liquaemin) anti-scar spray preparation method
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 100g physiological saline, 1g is added
Ramipril, 3g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 3g liquaemins and 1g urea, are stirred.And load spray
In mist bottle.
Matched somebody with somebody by the quality for changing spray reclaimed water and Ramipril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract
Than compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration
Trace spray, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 57 0.5% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1%
The asiaticosid of the liquaemin of thing+0.1%+0.1%) the anti-scar ointment containing urea preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;100mg enalaprils, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg accumulated snow are weighed with electronic balance
Careless glycosides and 100mg liquaemin, it is molten that enalapril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase
Solution;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains
0.5% compound ACE classes medicine (liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1%+
0.1% asiaticosid) the anti-scar ointment containing urea.
By changing enalapril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases
Ratio can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% mass fractions
Plain sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+2% of embodiment 58 7%
The plain asiaticosid of sodium+1%) the anti-scar ointment containing urea preparation
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;1g captoprils, 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 1g asiaticosids and 2g heparin are weighed with electronic balance
Sodium, captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;The mixing of water oil phase is filled
Divide and stir and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 7% compound ACE
Class medicine (asiaticosid of+2% liquaemin of+1% Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+1%) anti-scar containing urea
Trace ointment.
By changing captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases
Ratio can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% mass fractions
Plain sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ACEI+1% triamcinolone acetonide acetates+1% of embodiment 59 5%
The plain asiaticosid of sodium+1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 70 DEG C of waters bath with thermostatic control
It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml
Beaker, heating and melting simultaneously stir as oil phase;Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control
Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;1g Lei meter Pu are weighed with electronic balance
Profit, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins, Ramipril, triamcinolone acetonide acetate, ocean
Herba Alii fistulosi extract, liquaemin and asiaticosid add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature,
It is sealed in 5 DEG C of refrigerators.Above method obtains 5% compound ACE classes medicine (1%ACEI+1% triamcinolone acetonide acetates+1%
The asiaticosid of the liquaemin of Bulbus Allii Cepae extract+1%+1%) the anti-scar ointment containing numerous emulsifiers.
By changing Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases
Ratio can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% mass fractions
Plain sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 60 4% (Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+1%+
The asiaticosid of 0.5% liquaemin+1%) anti-scar normal saline solution preparation
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Under room temperature condition, claim
100g normal saline solutions are taken, 1g captoprils, 1g Bulbus Allii Cepae extracts, 500mg triamcinolone acetonide acetates, 1g are weighed with electronic balance
Asiaticosid and 500mg liquaemins, which are added in physiological saline, to be sufficiently stirred.Encapsulation preserves.Above method obtains 4% compound ACE classes
The anti-scar life of medicine (asiaticosid of+0.5% liquaemin of+1% Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+1%)
Manage saline solution.
By changing physiological saline and captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid matter
Amount proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin+
Asiaticosid) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ACEI+1% triamcinolone acetonide acetates+2% of embodiment 61 9%
The plain asiaticosid of sodium+2%) anti-scar gel preparation
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Under room temperature condition, claim
72g normal saline solutions are taken, add 2g lisinoprils, 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 2g asiaticosids and 2g livers
Plain sodium fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g
Fatty acid sorbitan.Above method obtains 9% compound ACE classes medicine, and (onion of 2%ACEI+1% triamcinolone acetonide acetates+2% is extracted
The asiaticosid of the liquaemin of thing+2%+2%) anti-scar gel.
By changing physiological saline and lisinopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid
Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration
Sodium+asiaticosid) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 62 0.5% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1%
The asiaticosid of the liquaemin of thing+0.1%+0.1%) anti-scar plastics preparation method
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Weigh 8g polyvinyl alcohol
(PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs
It is extremely well mixed.It is eventually adding 100mg Ramiprils, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg accumulated snow
Careless glycosides and 100mg liquaemin, is stirred well to and is completely dissolved, be cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid
Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration
Plain sodium+asiaticosid) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+2% of 6%ACEI+2% triamcinolone acetonide acetates+4% of embodiment 63 16%
The asiaticosid of liquaemin+2%) anti-scar bar cloth patch preparation method
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 50 DEG C of waters bath with thermostatic control
In, 6g lisinoprils, 4g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins are taken, is dissolved in 80g distillations
In water, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid;
4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and is sufficiently stirred
To being well mixed, room temperature is cooled to.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 16% compound ACE
Class medicine (asiaticosid of+2% liquaemin of+4% Bulbus Allii Cepae extract of 6%ACEI+2% triamcinolone acetonide acetates+2%) anti-scar bar cloth
Patch.
Matrix and lisinopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid are pasted by changing bar cloth
Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration
Plain sodium+asiaticosid) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+2% of 2%ACEI+2% triamcinolone acetonide acetates+2% of embodiment 64 10%
The asiaticosid of liquaemin+2%) anti-scar spray preparation method
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:In 100g physiological saline
In, 2g captoprils, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins and 1g urea are added, is filled
Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid
Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration
Plain sodium+asiaticosid) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
Embodiment 65 6% compound ACE classes medicine (2%ACEI+2%ARB+2% triamcinolone acetonide acetates) anti-scar containing urea
The preparation of ointment
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g,
White oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;In 70 DEG C of waters bath with thermostatic control
Take distilled water 32mL to add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Claimed with electronic balance
2g Ramiprils, 2g Losartan Potassiums and 2g triamcinolone acetonide acetates are taken, Ramipril, Losartan Potassium, triamcinolone acetonide acetate add oil
Phased soln;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains
To 6% compound ACE classes medicine (2%ACEI+2%ARB+2% triamcinolone acetonide acetates) anti-scar ointment containing urea.
0.05- can be obtained by the ratio for changing Ramipril, Losartan Potassium, triamcinolone acetonide acetate and ointment bases
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea of 25% mass fraction.
The compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) of embodiment 66 0.3% is containing urine
The preparation of the anti-scar ointment of element
By taking lisinopril+Losartan Potassium+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g,
White oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;In 70 DEG C of waters bath with thermostatic control
Take distilled water 32mL to add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Claimed with electronic balance
100mg lisinoprils, 100mg Losartan Potassiums and 100mg triamcinolone acetonide acetates are taken, how are lisinopril, Losartan Potassium, acetic acid Qu An
Moral adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of ice
In case.Above method obtains 0.3% compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) containing urine
The anti-scar ointment of element.
0.05- can be obtained by the ratio for changing lisinopril, Losartan Potassium, triamcinolone acetonide acetate and ointment bases
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea of 25% mass fraction.
The compound ACE classes medicine (0.3%ACEI+0.3%ARB+0.9% triamcinolone acetonide acetates) of embodiment 67 1.5% is containing more
The preparation of the kind anti-scar ointment of emulsifying agent
By taking Ramipril+Valsartan+triamcinolone acetonide acetate as an example:By stearic acid 4.8g, 18 in 70 DEG C of waters bath with thermostatic control
Alcohol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs
Uniformly it is used as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add 100ml in 70 DEG C of waters bath with thermostatic control
It is heated to 70 DEG C in beaker and is well mixed to be used as aqueous phase;With electronic balance weigh 300mg Ramiprils, 300mg Valsartans and
900mg triamcinolone acetonide acetates, Ramipril, Valsartan, triamcinolone acetonide acetate add oil phase dissolving;Finally aqueous phase oil phase is mixed
And be sufficiently stirred and be cooled to room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 1.5% compound ACE classes medicine (0.3%
ACEI+0.3%ARB+0.9% triamcinolone acetonide acetates) the anti-scar ointment containing numerous emulsifiers.
0.05-25% can be obtained by the ratio for changing Ramipril, Valsartan, triamcinolone acetonide acetate and ointment bases
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar ointment containing numerous emulsifiers of mass fraction.
Embodiment 68 5% compound ACE classes medicine (3%ACEI+1%ARB+1% triamcinolone acetonide acetates) anti-scar physiology salt
The preparation of the aqueous solution
By lisinopril+replace the smooth potassium+triamcinolone acetonide acetate of rice exemplified by:Under room temperature condition, 100g normal saline solutions are weighed,
Weighed in 3g lisinoprils, 1g Telmisartans and 1g triamcinolone acetonide acetates addition physiological saline and be sufficiently stirred with electronic balance.Envelope
Dress preserves.Above method obtains 5% compound ACE classes medicine (3%ACEI+1%ARB+1% triamcinolone acetonide acetates) anti-scar physiology
Saline solution.
By changing physiological saline and lisinopril, can obtain 0.05- for the smooth potassium of rice, triamcinolone acetonide acetate quality proportioning
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar normal saline solution of 25% concentration, with for inhomogeneity
Type scar obtains optimal anti-scar effect.
Embodiment 69 0.3% compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) anti-scar
The preparation of trace gel
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate as an example:Under room temperature condition, 72g normal saline solutions are weighed,
Add 100mg Ramiprils, 100mg Losartan Potassiums and 100mg triamcinolone acetonide acetates fully to dissolve, add 3g carboxymethyl celluloses
Plain sodium, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 0.3%
Compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) anti-scar gel.
By change physiological saline and Ramipril, Losartan Potassium, triamcinolone acetonide acetate quality proportioning can obtain 0.05-
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar gel of 25% concentration, with for different type scar or
Obtain optimal anti-scar effect.
Embodiment 70 5% compound ACE classes medicine (3%ACEI+1%ARB+1% triamcinolone acetonide acetates) anti-scar plastics
Preparation method
By taking lisinopril+Candesartan+triamcinolone acetonide acetate as an example:Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml steamings
In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally plus
Enter 3g lisinoprils, 1g Candesartans and 1g triamcinolone acetonide acetates, be stirred well to and be completely dissolved, be cooled to room temperature.Encapsulation is protected
Deposit.
By change plastics matrix and lisinopril, Candesartan, triamcinolone acetonide acetate quality proportioning can obtain
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar plastics of 0.05-25% concentration, with for inhomogeneity
Type scar obtains optimal anti-scar effect.
Embodiment 71 11% compound ACE classes medicine (6%ACEI+2%ARB+3% triamcinolone acetonide acetates) anti-scar bar cloth
Paste preparation method
By taking captopril+Telmisartan+triamcinolone acetonide acetate as an example:In 50 DEG C of waters bath with thermostatic control, 6g ACEI, 2g are taken
ARB and 3g triamcinolone acetonide acetates, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin,
2.5g peach gum, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains
To B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covering is anti-sticking
Layer, stripping and slicing.Above method obtains 11% compound ACE classes medicine (6%ACEI+2%ARB+3% triamcinolone acetonide acetates) anti-scar bar
Cloth pastes.
By change bar cloth paste matrix and captopril, Telmisartan, triamcinolone acetonide acetate quality proportioning can obtain
The anti-scar bar cloth patch of compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) of 0.05-25% concentration, with for inhomogeneity
Type scar obtains optimal anti-scar effect.
Embodiment 72 6% compound ACE classes medicine (1%ACEI+2%ARB+3% triamcinolone acetonide acetates) anti-scar spray
Preparation method
By taking lisinopril+Telmisartan+triamcinolone acetonide acetate as an example:In 100g physiological saline, addition 1g lisinoprils,
2g Telmisartans and 3g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and lisinopril, Telmisartan, triamcinolone acetonide acetate quality proportioning can obtain
Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar spray of 0.05-25% concentration, with for inhomogeneity
Type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 73 0.4% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+
0.1% Bulbus Allii Cepae extract) the anti-scar ointment containing urea preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Will be hard in 70 DEG C of waters bath with thermostatic control
Fatty acid magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70℃
Take distilled water 32mL to add in 100ml beakers in water bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With
Electronic balance weighs 100mg Ramiprils, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, thunder
Meter Pu Li, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving;Finally aqueous phase oil phase is mixed and abundant
Stirring is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE class medicines (0.1%ACEI+
The Bulbus Allii Cepae extract of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%) the anti-scar ointment containing urea.
Can by the ratio for changing Ramipril, Losartan Potassium, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
To obtain the compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions containing urine
The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 74 5% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%
Thing) the anti-scar ointment containing urea preparation
By taking enalapril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Will be hard in 70 DEG C of waters bath with thermostatic control
Fatty acid magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70℃
Take distilled water 32mL to add in 100ml beakers in water bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With
Electronic balance weighs 2g enalaprils, 1g Losartan Potassiums, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, and enalapril, chlorine are husky
Smooth potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue
Stir to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 5% compound ACE class medicines (2%ACEI+1%ARB+
The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) the anti-scar ointment containing urea.
Can by the ratio for changing enalapril, Losartan Potassium, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
To obtain the compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions containing urine
The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 75 0.6% (0.1%ACEI+0.1%ARB+0.2% triamcinolone acetonide acetates+
0.2% Bulbus Allii Cepae extract) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating
Melt and stir as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g are taken in 70 DEG C of waters bath with thermostatic control
Add in 100ml beakers and be heated to 70 DEG C and be well mixed to be used as aqueous phase;100mg Ramiprils, 100mg are weighed with electronic balance
Valsartan, 200mg Bulbus Allii Cepae extracts and 200mg triamcinolone acetonide acetates, Ramipril, Valsartan, triamcinolone acetonide acetate, onion carry
Thing is taken to add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.
Above method obtains the 0.6% compound ACE classes medicine (onion of 0.1%ACEI+0.1%ARB+0.2% triamcinolone acetonide acetates+0.2%
Extract) the anti-scar ointment containing numerous emulsifiers.
Can be with by the ratio for changing Ramipril, Valsartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions is obtained containing a variety of
The anti-scar ointment of emulsifying agent.
The compound ACE classes medicine of embodiment 76 8% (extract by the onion of 2%ACEI+3%ARB+1% triamcinolone acetonide acetates+2%
Thing) anti-scar normal saline solution preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Under room temperature condition, 100g lifes are weighed
Saline solution is managed, 2g enalaprils, 3g Telmisartans, 2g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates is weighed with electronic balance and adds
Enter in physiological saline and be sufficiently stirred.Encapsulation preserves.Above method obtains 8% compound ACE class medicines (2%ACEI+3%ARB+1%
The Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%) anti-scar normal saline solution.
By changing physiological saline and enalapril, Telmisartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract quality proportioning
It can obtain the anti-scar life of compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% concentration
Saline solution is managed, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 77 5% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%
Thing) anti-scar gel preparation
By taking Ramipril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Under room temperature condition, 72g lifes are weighed
Saline solution is managed, 2g Ramiprils, 1g Telmisartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates is added and fully dissolves, then
3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With
Upper method obtains 5% compound ACE classes medicine (Bulbus Allii Cepae extract of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%) anti-scar
Trace gel.
Matched somebody with somebody by the quality for changing physiological saline and Ramipril, Telmisartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract
Than compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) the anti-scar that can obtain 0.05-25% concentration
Gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 78 9% (extract by the onion of 3%ACEI+3%ARB+2% triamcinolone acetonide acetates+1%
Thing) anti-scar plastics preparation method
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:8g polyvinyl alcohol (PVA) is weighed to add
Enter into 88ml distilled water, be stirred well to and be completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirring to mixing
Uniformly.3g enalaprils, 3g Telmisartans, 1g Bulbus Allii Cepae extracts and 2g triamcinolone acetonide acetates are eventually adding, has been stirred well to
Fully dissolved, it is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and enalapril, Telmisartan, triamcinolone acetonide acetate and the quality of Bulbus Allii Cepae extract
Proportioning can obtain compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar of 0.05-25% concentration
Trace plastics, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 79 7% (extract by the onion of 3%ACEI+2%ARB+1% triamcinolone acetonide acetates+1%
Thing) anti-scar bar cloth patch preparation method
By taking lisinopril+Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 50 DEG C of waters bath with thermostatic control, 3g is taken
Lisinopril, 2g Candesartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, are dissolved in 80g distilled water, add into the aqueous solution
Enter 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken,
Add in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to
Room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 7% compound ACE class medicines (3%ACEI+2%
The Bulbus Allii Cepae extract of ARB+1% triamcinolone acetonide acetates+1%) anti-scar bar cloth patch.
The quality of matrix and lisinopril, Candesartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract is pasted by changing bar cloth
Proportioning can obtain compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar of 0.05-25% concentration
Trace bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 80 0.4% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+
0.1% Bulbus Allii Cepae extract) anti-scar spray preparation method
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:In 100g physiological saline, add
100mg Ramiprils, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates and 1g urea, are fully stirred
Mix uniformly.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, Losartan Potassium, triamcinolone acetonide acetate and the quality of Bulbus Allii Cepae extract
Proportioning can obtain compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar of 0.05-25% concentration
Trace spray, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 81 6% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%
The liquaemin of thing+1%) the anti-scar ointment containing urea preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;2g enalaprils, 1g Telmisartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g heparin are weighed with electronic balance
Sodium, enalapril, Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally by aqueous phase oil
Mix and be sufficiently stirred and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 6% compound ACE class medicines
(ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar ointment containing urea.
By changing enalapril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
Ratio can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% mass fractions
+ liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 82 9% (extract by the onion of 3%ACEI+1%ARB+1% triamcinolone acetonide acetates+3%
The liquaemin of thing+1%) the anti-scar ointment containing urea preparation
By taking lisinopril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 70 DEG C of waters bath with thermostatic control
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil phase;
Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings and be used as water
Phase;3g lisinoprils, 1g Valsartans, 3g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins are weighed with electronic balance, is relied
Promise Puli, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;The mixing of water oil phase is sufficiently stirred simultaneously
Add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 9% compound ACE class medicines
(liquaemin of+3% Bulbus Allii Cepae extract of 3%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%) anti-scar ointment containing urea.
By the ratio for changing lisinopril, Valsartan, triamcinolone acetonide acetate, liquaemin, Bulbus Allii Cepae extract and ointment bases
Example can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+
Liquaemin) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 83 0.5% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+
The liquaemin of 0.1% Bulbus Allii Cepae extract+0.1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 70 DEG C of waters bath with thermostatic control
It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml
Beaker, heating and melting simultaneously stir as oil phase;Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control
Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;100mg thunder rice is weighed with electronic balance
Puli, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, Ramipril, chlorine
Husky smooth potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally aqueous phase oil phase is mixed and fully stirred
Mix and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE class medicines (0.1%ACEI+
The liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%) the anti-scar containing numerous emulsifiers is soft
Cream.
By changing Ramipril, Losartan Potassium, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases
Ratio can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% mass fractions
+ liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 84 10% (extract by the onion of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2%
The liquaemin of thing+2%) anti-scar normal saline solution preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Under room temperature condition, claim
100g normal saline solutions are taken, it is bent to weigh 2g enalaprils, 2g Telmisartans, 2g Bulbus Allii Cepae extracts, 2g acetic acid with electronic balance
An Naide and 2g liquaemins are added in physiological saline and are sufficiently stirred.Encapsulation preserves.Above method obtains 10% compound ACE class medicines
(liquaemin of+2% Bulbus Allii Cepae extract of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2%) anti-scar normal saline solution.
By changing physiological saline and enalapril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract matter
Amount proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration
Plain sodium) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 85 6% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%
The liquaemin of thing+1%) anti-scar gel preparation
By taking lisinopril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Under room temperature condition, claim
72g normal saline solutions are taken, add 2g lisinoprils, 1g Telmisartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g livers
Plain sodium fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g
Fatty acid sorbitan.Above method obtains 6% compound ACE classes medicine (2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%
The liquaemin of Bulbus Allii Cepae extract+1%) anti-scar gel.
By changing physiological saline and lisinopril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract
Quality proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+
Liquaemin) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 86 20% (extract by the onion of 4%ACEI+4%ARB+4% triamcinolone acetonide acetates+4%
The liquaemin of thing+4%) anti-scar plastics preparation method
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:Weigh 8g polyvinyl alcohol
(PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs
It is extremely well mixed.It is eventually adding 4g enalaprils, 4g Telmisartans, 4g Bulbus Allii Cepae extracts, 4g triamcinolone acetonide acetates and 4g heparin
Sodium, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and enalapril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract
Quality proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% concentration
+ liquaemin) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 87 8% (extract by the onion of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+2%
The liquaemin of thing+1%) anti-scar bar cloth patch preparation method
By taking Ramipril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 50 DEG C of waters bath with thermostatic control
In, 1g Ramiprils, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins are taken, is dissolved in 80g distilled water
In, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid;Separately
4g Sodium Polyacrylates are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and is stirred well to
It is well mixed, it is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 8% compound ACE class medicines
The anti-scar bar cloth patch of thing (liquaemin of+2% Bulbus Allii Cepae extract of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+1%).
Matrix and Ramipril, Valsartan, triamcinolone acetonide acetate, liquaemin, Bulbus Allii Cepae extract are pasted by changing bar cloth
Quality proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+
Liquaemin) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 88 7% (extract by the onion of 2%ACEI+2%ARB+1% triamcinolone acetonide acetates+1%
The liquaemin of thing+1%) anti-scar spray preparation method
By taking lisinopril+Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example:In 100g physiological saline
In, 2g lisinoprils, 2g Candesartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins and 1g urea are added, is filled
Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and lisinopril, Candesartan, triamcinolone acetonide acetate, liquaemin, Bulbus Allii Cepae extract
Quality proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% concentration
+ liquaemin) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 89 0.6% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+
The asiaticosid of+0.1% liquaemin of 0.1% Bulbus Allii Cepae extract+0.1%) the anti-scar ointment containing urea preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:70
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs
Uniformly it is used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea
10g dissolvings are used as aqueous phase;With electronic balance weigh 100mg Ramiprils, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts,
100mg triamcinolone acetonide acetate 100mg asiaticosids and 100mg liquaemins, Ramipril, Losartan Potassium, triamcinolone acetonide acetate, ocean
Herba Alii fistulosi extract, liquaemin and asiaticosid add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature,
It is sealed in 5 DEG C of refrigerators.Above method obtains 0.6% compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% vinegar
The sour asiaticosid of+0.1% liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+0.1%+0.1%) the anti-scar ointment containing urea.
By change Ramipril, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+
Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 90 8% (extract by the onion of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+1%
The asiaticosid of the liquaemin of thing+1%+1%) the anti-scar ointment containing urea preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:70
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs
Uniformly it is used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea
10g dissolvings are used as aqueous phase;How 1g enalaprils, 2g Telmisartans, 1g Bulbus Allii Cepae extracts, 2g acetic acid Qu An are weighed with electronic balance
Moral 1g asiaticosids and 1g liquaemins, enalapril, Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and accumulated snow
Careless glycosides adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C
In refrigerator.Above method obtains 8% compound ACE classes medicine, and (onion of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+1% carries
Take the asiaticosid of the liquaemin of thing+1%+1%) the anti-scar ointment containing urea.
By change enalapril, Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+
Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 91 16% (extract by the onion of 2%ACEI+2%ARB+6% triamcinolone acetonide acetates+2%
The asiaticosid of the liquaemin of thing+2%+2%) the anti-scar ointment containing numerous emulsifiers preparation
By taking enalapril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:At 70 DEG C
Stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put in water bath with thermostatic control
Enter 100ml beakers, heating and melting simultaneously stirs as oil phase;Distilled water 60mL, glycerine 10ml, ten are taken in 70 DEG C of waters bath with thermostatic control
Sodium dialkyl sulfate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;2g is weighed with electronic balance
Enalapril, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 6g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins, enalapril,
Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;Finally aqueous phase oil phase is mixed
Merging, which is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 16% compound ACE classes medicine (2%
The asiaticosid of+2% liquaemin of+2% Bulbus Allii Cepae extract of ACEI+2%ARB+6% triamcinolone acetonide acetates+2%) contain numerous emulsifiers
Anti- scar ointment.
By changing enalapril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and soft
The ratio of cream base matter can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+ocean of 0.05-25% mass fractions
Herba Alii fistulosi extract+liquaemin+asiaticosid) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 92 22% (extract by the onion of 6%ACEI+4%ARB+6% triamcinolone acetonide acetates+2%
The asiaticosid of the liquaemin of thing+2%+2%) anti-scar normal saline solution preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Room temperature
Under the conditions of, weigh 100g normal saline solutions, with electronic balance weigh 6g Ramiprils, 4g Losartan Potassiums, 2g Bulbus Allii Cepae extracts,
6g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins are added in physiological saline and are sufficiently stirred.Encapsulation preserves.Above method obtains
To 22% compound ACE classes medicine (liquaemin of+2% Bulbus Allii Cepae extract of 6%ACEI+4%ARB+6% triamcinolone acetonide acetates+2%+
2% asiaticosid) anti-scar normal saline solution.
By change physiological saline and Ramipril, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and
Asiaticosid quality proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+onion of 0.05-25% concentration
Extract+liquaemin+asiaticosid) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar
Effect.
The compound ACE classes medicine of embodiment 93 10% (extract by the onion of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2%
The asiaticosid of the liquaemin of thing+1%+1%) anti-scar gel preparation
By taking lisinopril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:Room temperature bar
Under part, weigh 72g normal saline solutions, add 2g lisinoprils, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates,
1g asiaticosids and 1g liquaemins fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.Finally plus
Enter 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 10% compound ACE class medicines (2%ACEI+2%ARB+2%
The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%+1%) anti-scar gel.
By changing physiological saline and lisinopril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and product
The quality proportioning of Asiaticoside can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+onion of 0.05-25% concentration
Extract+liquaemin+asiaticosid) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 94 12% (extract by the onion of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2%
The asiaticosid of the liquaemin of thing+2%+2%) anti-scar plastics preparation method
By taking lisinopril+Valsartan as an example+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid exemplified by:Claim
Take 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, be stirred well to and be completely dissolved in 90 DEG C of waters bath with thermostatic control, add
3ml glycerine, stir to well mixed.How it is eventually adding 2g lisinoprils, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g acetic acid Qu An
Moral, 2g asiaticosids and 2g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and lisinopril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and
The quality proportioning of asiaticosid can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+ocean of 0.05-25% concentration
Herba Alii fistulosi extract+liquaemin+asiaticosid) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 95 11% (extract by the onion of 3%ACEI+2%ARB+1% triamcinolone acetonide acetates+2%
The asiaticosid of the liquaemin of thing+2%+1%) anti-scar bar cloth patch preparation method
By taking enalapril+Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:50
In DEG C water bath with thermostatic control, take 3g enalaprils, 2g Candesartans, 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and
2g liquaemins, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums,
0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally
A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With
Upper method obtains the 11% compound ACE classes medicine (Bulbus Allii Cepae extract+2% of 3%ACEI+2%ARB+1% triamcinolone acetonide acetates+2%
The asiaticosid of liquaemin+1%) anti-scar bar cloth patch.
Matrix and enalapril, Candesartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin are pasted by changing bar cloth
With the quality proportioning of asiaticosid can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+
Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar and imitate
Fruit.
The compound ACE classes medicine of embodiment 96 9% (extract by the onion of 1%ACEI+1%ARB+3% triamcinolone acetonide acetates+2%
The asiaticosid of the liquaemin of thing+1%+1%) anti-scar spray preparation method
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example:
In 100g physiological saline, 1g Ramiprils, 1g Losartan Potassiums, 2g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates, 1g centellas are added
Glycosides and 1g liquaemins and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin
With the quality proportioning of asiaticosid can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+
Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar spray, for different type scar or to obtain optimal anti-scar and imitate
Fruit.
The compound ACE classes medicine of embodiment 97 0.4% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140)+0.1% triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;100mg Ramiprils, 100mg L-733060,100mg DALBK (or HOE-140) and 100mg are weighed with electronic balance
Triamcinolone acetonide acetate, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving;Finally
Aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.4% compound
ACE classes medicine (triamcinolone acetonide acetates of 0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1%) is containing urine
The anti-scar ointment of element.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases
Example can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% mass fractions
Sour Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ACEI+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 98 4%
Triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;How 1g Ramiprils, 1g L-733060,1g DALBK (or HOE-140) and 1g acetic acid Qu An are weighed with electronic balance
Moral, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving;The mixing of water oil phase is abundant
Stir and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 4% compound ACE classes
Medicine (triamcinolone acetonide acetates of 1%ACEI+1%L-733060+1%DALBK (or HOE-140)+1%) anti-scar containing urea is soft
Cream.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases
Example can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% mass fractions
Sour Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% of embodiment 99 8%
Triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control
It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml
Beaker, heating and melting simultaneously stir as oil phase;Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control
Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;1g Lei meter Pu are weighed with electronic balance
Profit, 2g L-733060,3g DALBK (or HOE-140) and 2g triamcinolone acetonide acetates, Ramipril, L-733060, DALBK (or
HOE-140), triamcinolone acetonide acetate adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed
It is stored in 5 DEG C of refrigerators.Above method obtain 8% compound ACE classes medicine (1%ACEI+2%L-733060+3%DALBK (or
HOE-140)+2% triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases
Example can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% mass fractions
Sour Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 100 5% (1%ACEI+2%L-733060+1%DALBK (or HOE-140)+
1% triamcinolone acetonide acetate) anti-scar normal saline solution preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:Under room temperature condition, weigh
100g normal saline solutions, 1g Ramiprils, 2g L-733060,1g DALBK (or HOE-140) and 1g are weighed with electronic balance
Triamcinolone acetonide acetate is added in physiological saline and is sufficiently stirred.Encapsulation preserves.Above method obtains 5% compound ACE classes medicine (1%
The triamcinolone acetonide acetates of ACEI+2%L-733060+1%DALBK (or HOE-140)+1%) anti-scar normal saline solution.
By changing physiological saline and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate quality
Proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+acetic acid song of 0.05-25% concentration
An Naide) anti-scar normal saline solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 101 7% (2%ACEI+2%L-733060+2%DALBK (or HOE-140)+
1% triamcinolone acetonide acetate) anti-scar gel preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:Under room temperature condition, weigh
72g normal saline solutions, how add 2g Ramiprils, 2g L-733060,2g DALBK (or HOE-140) and 1g acetic acid Qu An
Moral fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fat
Fat acid sorb is smooth.Above method obtains 7% compound ACE classes medicine (2%ACEI+2%L-733060+2%DALBK (or HOE-
140)+1% triamcinolone acetonide acetate) anti-scar gel.
By the matter for changing physiological saline and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate
Amount proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration
Triamcinolone acetonide) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 102 5% (2%ACEI+1%L-733060+1%DALBK (or HOE-140)+
1% triamcinolone acetonide acetate) anti-scar plastics preparation method
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:Weigh 8g polyvinyl alcohol
(PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs
It is extremely well mixed.How it is eventually adding 2g Ramiprils, 1g L-733060,1g DALBK (or HOE-140) and 1g acetic acid Qu An
Moral, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate
Quality proportioning can obtain 0.4% compound ACE classes medicine (ACEI+L-733060+DALBK (or the HOE- of 0.05-25% concentration
140)+triamcinolone acetonide acetate) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 103 15% (4%ACEI+4%L-733060+4%DALBK (or HOE-140)+
3% triamcinolone acetonide acetate) anti-scar bar cloth patch preparation method
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 50 DEG C of waters bath with thermostatic control
In, 4g Ramiprils, 4g L-733060,4g DALBK (or HOE-140) and 3g triamcinolone acetonide acetates are taken, is dissolved in 80g distilled water
In, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid;Separately
4g Sodium Polyacrylates are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and is stirred well to
It is well mixed, it is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 15% compound ACE classes
The anti-scar bar cloth patch of medicine (triamcinolone acetonide acetates of 4%ACEI+4%L-733060+4%DALBK (or HOE-140)+3%).
Matrix and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate are pasted by changing bar cloth
Quality proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% concentration
Sour Triamcinolone acetonide) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 104 13% (3%ACEI+3%L-733060+4%DALBK (or HOE-140)+
3% triamcinolone acetonide acetate) anti-scar spray preparation method
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 100g physiological saline
In, 3g Ramiprils, 3g L-733060,4g DALBK (or HOE-140) and 3g triamcinolone acetonide acetates and 1g urea are added, is filled
Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate
Quality proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% concentration
Sour Triamcinolone acetonide) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 105 11% (2%ACEI+1%L-733060+3%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:70
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs
Uniformly it is used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea
10g dissolvings are used as aqueous phase;2g captoprils, 1g L-733060,3g DALBK (or HOE-140), 2g oceans are weighed with electronic balance
Herba Alii fistulosi extract and 3g triamcinolone acetonide acetates, captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, onion
Extract adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators
In.Above method obtains 11% compound ACE classes medicine (2%ACEI+1%L-733060+3%DALBK (or HOE-140)+3%
The Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By change captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 106 8% (1%ACEI+3%L-733060+1%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:70
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs
Uniformly it is used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea
10g dissolvings are used as aqueous phase;1g captoprils, 3g L-733060,1g DALBK (or HOE-140), 2g oceans are weighed with electronic balance
Herba Alii fistulosi extract and 1g triamcinolone acetonide acetates, captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, onion
Extract adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5
In DEG C refrigerator.Above method obtains 8% compound ACE classes medicine (1%ACEI+3%L-733060+1%DALBK (or HOE-140)
The Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By change captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 107 6% (2%ACEI+1%L-733060+1%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:70
By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g in DEG C water bath with thermostatic control
100ml beakers are put into, heating and melting simultaneously stirs as oil phase;Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL, glycerine 10ml,
Lauryl sodium sulfate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;Weighed with electronic balance
2g captoprils, 1g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, Kato
Puli, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving;Finally by aqueous phase
Oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 6% compound ACE class medicines
(Bulbus Allii Cepae extract of 2%ACEI+1%L-733060+1%DALBK (or HOE-140)+1% triamcinolone acetonide acetate+1%) is containing a variety of
The anti-scar ointment of emulsifying agent.
By change captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 108 0.5% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar normal saline solution preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Room temperature
Under the conditions of, weigh 100g normal saline solutions, with electronic balance weigh 100mg captoprils, 100mg L-733060,
100mgDALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates are added in physiological saline and fully stirred
Mix.Encapsulation preserves.Above method obtains 0.5% compound ACE class medicines (0.1%ACEI+0.1%L-733060+0.1%DALBK
The Bulbus Allii Cepae extract of (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1%) anti-scar normal saline solution.
By changing physiological saline and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean
Herba Alii fistulosi extract quality proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-
140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar normal saline solution, for different type scar or to obtain optimal
Anti- scar effect.
The compound ACE classes medicine of embodiment 109 7% (2%ACEI+1%L-733060+2%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar gel preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Room temperature
Under the conditions of, 72g normal saline solutions are weighed, add 2g captoprils, 1g L-733060,2g DALBK (or HOE-140), 1g
Bulbus Allii Cepae extract and 1g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.
It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 7% compound ACE class medicines (2%ACEI+1%L-
The Bulbus Allii Cepae extract of 733060+2%DALBK (or HOE-140)+1% triamcinolone acetonide acetate+1%) anti-scar gel.
By changing physiological saline and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean
The quality proportioning of Herba Alii fistulosi extract can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar gel, for different type scar or to obtain optimal anti-scar
Trace effect.
The compound ACE classes medicine of embodiment 110 15% (3%ACEI+3%L-733060+3%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+3%) anti-scar plastics preparation method
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Weigh
8g polyvinyl alcohol (PVA) is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, adds
3ml glycerine, stir to well mixed.It is eventually adding 3g captoprils, 3g L-733060,3g DALBK (or HOE-140), 3g
Bulbus Allii Cepae extract and 3g triamcinolone acetonide acetates, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and
The quality proportioning of Bulbus Allii Cepae extract can obtain 0.4% compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics, for different type scar or to take
Obtain most preferably anti-scar effect.
The compound ACE classes medicine of embodiment 111 12% (3%ACEI+2%L-733060+3%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) anti-scar bar cloth patch preparation method
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:50
In DEG C water bath with thermostatic control, 3g captoprils, 2g L-733060,3g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts and 2g vinegar are taken
Sour Triamcinolone acetonide, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums,
0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally
A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With
Upper method obtains 12% compound ACE classes medicine, and (acetic acid of 3%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% is bent
The Bulbus Allii Cepae extracts of An Naide+2%) anti-scar bar cloth patch.
By change bar cloth paste matrix and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and
The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-
Scar effect.
The compound ACE classes medicine of embodiment 112 9% (2%ACEI+3%L-733060+2%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar spray preparation method
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:
In 100g physiological saline, add 2g captoprils, 3g L-733060,2g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts and
1g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and
The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar spray, for different type scar or to obtain optimal anti-
Scar effect.
The compound ACE classes medicine of embodiment 113 0.6% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control
And stir as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add
Urea 10g dissolvings are used as aqueous phase;With electronic balance weigh 100mg lisinoprils, 100mg L-733060,100mgDALBK (or
HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, lisinopril, L-733060,
DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally aqueous phase oil phase is mixed
Merging, which is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.6% compound ACE class medicines
(onion of 0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1% carries
Take the liquaemin of thing+0.1%) the anti-scar ointment containing urea.
By changing lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion
The ratio of extract and ointment bases can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% mass fractions
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 114 10% (1%ACEI+2%L-733060+3%DALBK (or HOE-140)+
The liquaemin of+1% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+1%) the anti-scar ointment containing urea preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control
And stir as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add
Urea 10g dissolvings are used as aqueous phase;With electronic balance weigh 1g lisinoprils, 2g L-733060,3g DALBK (or HOE-140),
1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins, lisinopril, L-733060, DALBK (or HOE-140), acetic acid
Triamcinolone acetonide, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue to stir
Mix to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 10% compound ACE class medicines (1%ACEI+2%L-
The liquaemin of+1% Bulbus Allii Cepae extract of 733060+3%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+1%) the anti-scar containing urea
Trace ointment.
By changing lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion
The ratio of extract and ointment bases can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% mass fractions
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 115 17% (6%ACEI+2%L-733060+3%DALBK (or HOE-140)+
The liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing numerous emulsifiers preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, nipalgin in 70 DEG C of waters bath with thermostatic control
Ethyl ester 0.3g is put into 100ml beakers, and heating and melting simultaneously stirs as oil phase;Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL,
Glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;Use electronics
How balance weighs 6g lisinoprils, 2g L-733060,3g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 2g acetic acid Qu An
Moral and 2g liquaemins, lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, heparin
Sodium adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.With
Upper method obtains 17% compound ACE classes medicine, and (acetic acid of 6%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% is bent
The liquaemin of the Bulbus Allii Cepae extracts of An Naide+2%+2%) the anti-scar ointment containing numerous emulsifiers.
By changing lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin, onion carry
The ratio of thing and ointment bases is taken to obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% mass fractions
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 116 10% (3%ACEI+2%L-733060+2%DALBK (or HOE-140)+
The liquaemin of+1% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar normal saline solution preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Under room temperature condition, weigh 100g normal saline solutions, with electronic balance weigh 3g lisinoprils, 2g L-733060,
2gDALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins are added in physiological saline and fully stirred
Mix.Encapsulation preserves.Above method obtains 10% compound ACE classes medicine (3%ACEI+2%L-733060+2%DALBK (or HOE-
140) liquaemin of+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) anti-scar normal saline solution.
By changing physiological saline and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver
Plain sodium, Bulbus Allii Cepae extract quality proportioning can obtain the compound ACE class medicines (ACEI+L-733060+DALBK of 0.05-25% concentration
(or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar normal saline solution, with for different type
Scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 117 19% (6%ACEI+3%L-733060+2%DALBK (or HOE-140)+
The liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+4%) anti-scar gel preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Under room temperature condition, 72g normal saline solutions are weighed, add 6g lisinoprils, 3g L-733060,2g DALBK (or HOE-
140), 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 4g liquaemins fully dissolve, and add 3g sodium carboxymethylcelluloses, and 25
It is swelled overnight under the conditions of DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 19% compound ACE classes
Medicine (Bulbus Allii Cepae extract of 6%ACEI+3%L-733060+2%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+2%+
4% liquaemin) anti-scar gel.
By changing physiological saline and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver
Plain sodium, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar gel, with for different type scar
Or obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 118 0.6% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar plastics preparation method
By taking lisinopril+L-733060+DALBK (or HOE-140) as an example:8g polyvinyl alcohol (PVA) is weighed to be added to
In 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.
Be eventually adding 100mg lisinoprils, 100mg L-733060,100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts,
100mg triamcinolone acetonide acetates and 100mg liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
Liquaemin, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar plastics, with for different type scar
Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 119 15% (2%ACEI+2%L-733060+2%DALBK (or HOE-140)+
The liquaemin of+4% Bulbus Allii Cepae extract of 4% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch preparation method
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:In 50 DEG C of waters bath with thermostatic control, 2g lisinoprils, 2g L-733060,2g DALBK (or HOE-140), the extraction of 4g onions are taken
Thing, 4g triamcinolone acetonide acetates and 1g liquaemins, are dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine,
2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving is stirred
Mix uniformly, obtain B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with,
Cover adherent layer, stripping and slicing.Above method obtain 15% compound ACE classes medicine (2%ACEI+2%L-733060+2%DALBK (or
HOE-140) the liquaemin of+4% Bulbus Allii Cepae extract of+4% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch.
By change bar cloth paste matrix and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
Liquaemin, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar bar cloth patch, with for different type scar
Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 120 11% (3%ACEI+2%L-733060+2%DALBK (or HOE-140)+
The liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar spray preparation method
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:In 100g physiological saline, 3g lisinoprils, 2g L-733060,2g DALBK (or HOE-140), the extraction of 2g onions are added
Thing, 1g triamcinolone acetonide acetates and 1g liquaemins and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
Liquaemin, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar spray, with for different type scar
Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 121 25% (4%ACEI+4%L-733060+4%DALBK (or HOE-140)+
The asiaticosid of+4% liquaemin of+6% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+1%) the anti-scar ointment containing urea preparation
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn
Cup, heating are melted and stirred as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to
70 DEG C, add urea 10g dissolvings and be used as aqueous phase;4g enalaprils, 4g L-733060,4gDALBK are weighed with electronic balance
(or HOE-140), 6g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 1g asiaticosids and 4g liquaemins, enalapril, L-
733060th, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;
Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 25%
(onion of 4%ACEI+4%L-733060+4%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+6% carries square ACE classes medicine
Take the asiaticosid of the liquaemin of thing+4%+1%) the anti-scar ointment containing urea.
By changing enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ACEI+ of 0.05-25% mass fractions
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea
Trace ointment.
The compound ACE classes medicine of embodiment 122 0.7% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) resist containing urea
The preparation of scar ointment
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn
Cup, heating are melted and stirred as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to
70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With electronic balance weigh 100mg enalaprils, 100mg L-733060,
100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetate 100mg asiaticosids and 100mg
Liquaemin, enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and product
Asiaticoside adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5
In DEG C refrigerator.Above method obtain 0.7% compound ACE classes medicine (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) resist containing urea
Scar ointment.
By changing enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ACEI+ of 0.05-25% mass fractions
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea
Trace ointment.
The compound ACE classes medicine of embodiment 123 21% (3%ACEI+3%L-733060+3%DALBK (or HOE-140)+
The asiaticosid of+3% liquaemin of+3% Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+3%) the anti-scar ointment containing numerous emulsifiers
Prepare
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine in 70 DEG C of waters bath with thermostatic control
16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs as oil phase;Steaming is taken in 70 DEG C of waters bath with thermostatic control
Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as water
Phase;3g enalaprils, 3g L-733060,3g DALBK (or HOE-140), 3g Bulbus Allii Cepae extracts, 3g vinegar are weighed with electronic balance
Sour Triamcinolone acetonide, 3g asiaticosids and 3g liquaemins, enalapril, L-733060, DALBK (or HOE-140), acetic acid Qu An how
Moral, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to
Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 21% compound ACE class medicines (3%ACEI+3%L-733060+
The asiaticosid of+3% liquaemin of 3%DALBK (or HOE-140)+3% Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+3%) containing more
The kind anti-scar ointment of emulsifying agent.
By changing enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ACEI+ of 0.05-25% mass fractions
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) contain a variety of emulsifications
The anti-scar ointment of agent.
The compound ACE classes medicine of embodiment 124 7% (1%ACEI+1%L-733060+1%DALBK (or HOE-140)+
The asiaticosid of+1% liquaemin of+1% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar normal saline solution preparation
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Under room temperature condition, 100g normal saline solutions are weighed, 1g enalaprils, 1g L- are weighed with electronic balance
733060th, 1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins add
Enter in physiological saline and be sufficiently stirred.Encapsulation preserves.Above method obtains 7% compound ACE class medicines (1%ACEI+1%L-
The centella of+1% liquaemin of 733060+1%DALBK (or HOE-140)+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%
Glycosides) anti-scar normal saline solution.
By changing physiological saline and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean
Herba Alii fistulosi extract, liquaemin and asiaticosid quality proportioning can obtain the compound ACE class medicines (ACEI+L- of 0.05-25% concentration
733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar physiology salt
The aqueous solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 125 15% (3%ACEI+2%L-733060+2%DALBK (or HOE-140)+
The asiaticosid of+2% liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) anti-scar gel preparation
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Under room temperature condition, 72g normal saline solutions are weighed, add 3g enalaprils, 2g L-733060,2g
DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins fully dissolve, then
3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With
Upper method obtains 15% compound ACE classes medicine, and (acetic acid of 3%ACEI+2%L-733060+2%DALBK (or HOE-140)+2% is bent
The asiaticosid of+2% liquaemin of the Bulbus Allii Cepae extracts of An Naide+2%+2%) anti-scar gel.
By changing physiological saline and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean
The quality proportioning of Herba Alii fistulosi extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+L- of 0.05-25% concentration
733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar gel, with
For different type scar or obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 126 10% (2%ACEI+3%L-733060+1%DALBK (or HOE-140)+
The asiaticosid of+1% liquaemin of+1% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar plastics preparation method
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, be stirred well in 90 DEG C of waters bath with thermostatic control
It is completely dissolved, adds 3ml glycerine, stirs to well mixed.It is eventually adding 2g enalaprils, 3g L-733060,1gDALBK
(or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins, it is stirred well to completely molten
Solution, is cooled to room temperature.Encapsulation preserves.
By change plastics matrix and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+ of 0.05-25% concentration
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar film
Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 127 10% (1%ACEI+2%L-733060+2%DALBK (or HOE-140)+
The asiaticosid of+1% liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch preparation method
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:In 50 DEG C of waters bath with thermostatic control, 1g enalaprils, 2g L-733060,2g DALBK (or HOE-140), 2g are taken
Bulbus Allii Cepae extract, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins, are dissolved in 80g distilled water, are added into the aqueous solution
2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added
Into 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room
Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 10% compound ACE class medicines (1%ACEI+2%L-
The centella of+1% liquaemin of 733060+2%DALBK (or HOE-140)+2% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%
Glycosides) anti-scar bar cloth patch.
By change bar cloth paste matrix and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+ of 0.05-25% concentration
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar bar cloth
Patch, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 128 0.7% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) spray of anti-scar
Mist agent preparation method
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:In 100g physiological saline, add 0.1g enalaprils, 0.1g L-733060,0.1g DALBK (or
HOE-140), 0.1g Bulbus Allii Cepae extracts, 0.1g triamcinolone acetonide acetates, 0.1g asiaticosids and 0.1g liquaemins and 1g urea, fill
Divide and stir.And it is fitted into spray bottle.
By change spray reclaimed water and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+ of 0.05-25% concentration
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) spraying of anti-scar
Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (2%ARB+1%L-733060+3%DALBK (or HOE-140)+2% of embodiment 129 8%
Triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;How 2g Losartan Potassiums, 1g L-733060,3g DALBK (or HOE-140) and 2g acetic acid Qu An are weighed with electronic balance
Moral, Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving;Finally by aqueous phase oil phase
Mix and be sufficiently stirred and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 8% compound ACE classes medicine (2%
The triamcinolone acetonide acetates of ARB+1%L-733060+3%DALBK (or HOE-140)+2%) the anti-scar ointment containing urea.
By changing Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases
Example can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% mass fractions
Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 130 0.4% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140)+0.1% triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control
Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil
Phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts
Aqueous phase;100mg Losartan Potassiums, 100mg L-733060,100mg DALBK (or HOE-140) and 100mg are weighed with electronic balance
Triamcinolone acetonide acetate, Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving;Water oil
Mix and be sufficiently stirred and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains
0.4% compound ACE classes medicine (the acetic acid Qu An of 0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1%
Nai De) the anti-scar ointment containing urea.
By changing Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases
Example can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% mass fractions
Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% of embodiment 131 6%
Triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 70 DEG C of waters bath with thermostatic control
It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml
Beaker, heating and melting simultaneously stir as oil phase;Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control
Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;1g Losartans are weighed with electronic balance
Potassium, 2g L-733060,2g DALBK (or HOE-140) and 1g triamcinolone acetonide acetates, Losartan Potassium, L-733060, DALBK (or
HOE-140), triamcinolone acetonide acetate adds oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed
It is stored in 5 DEG C of refrigerators.Above method obtain 6% compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or
HOE-140)+1% triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers.
By changing Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases
Example can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% mass fractions
Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 132 12% (3%ARB+4%L-733060+2%DALBK (or HOE-140)+
3% triamcinolone acetonide acetate) anti-scar normal saline solution preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:Under room temperature condition, weigh
100g normal saline solutions, 3g Losartan Potassiums, 4g L-733060,2g DALBK (or HOE-140) and 3g are weighed with electronic balance
Triamcinolone acetonide acetate is added in physiological saline and is sufficiently stirred.Encapsulation preserves.Above method obtains 12% compound ACE classes medicine (3%
The triamcinolone acetonide acetates of ARB+4%L-733060+2%DALBK (or HOE-140)+3%) anti-scar normal saline solution.
By changing physiological saline and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate quality
Proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid Qu An of 0.05-25% concentration
Nai De) anti-scar normal saline solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (3%ARB+2%L-733060+1%DALBK (or HOE-140)+1% of embodiment 133 7%
Triamcinolone acetonide acetate) anti-scar gel preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:Under room temperature condition, weigh
72g normal saline solutions, how add 3g Losartan Potassiums, 2g L-733060,1g DALBK (or HOE-140) and 1g acetic acid Qu An
Moral fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fat
Fat acid sorb is smooth.Above method obtains 7% compound ACE classes medicine (3%ARB+2%L-733060+1%DALBK (or HOE-
140)+1% triamcinolone acetonide acetate) anti-scar gel.
By the matter for changing physiological saline and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate
Amount proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid song of 0.05-25% concentration
An Naide) anti-scar gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 134 20% (5%ARB+5%L-733060+5%DALBK (or HOE-140)+
5% triamcinolone acetonide acetate) anti-scar plastics preparation method
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:Weigh 8g polyvinyl alcohol
(PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs
It is extremely well mixed.How it is eventually adding 5g Losartan Potassiums, 5g L-733060,5g DALBK (or HOE-140) and 5g acetic acid Qu An
Moral, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate
Quality proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration
Triamcinolone acetonide) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 135 11% (6%ARB+2%L-733060+1%DALBK (or
HOE-140)+2% triamcinolone acetonide acetate) anti-scar bar cloth patch preparation method
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 50 DEG C of waters bath with thermostatic control
In, 6g Losartan Potassiums, 2g L-733060,1g DALBK (or HOE-140) and 2g triamcinolone acetonide acetates are taken, is dissolved in 80g distilled water
In, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid;Separately
4g Sodium Polyacrylates are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and is stirred well to
It is well mixed, it is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 11% compound ACE classes
The anti-scar bar cloth patch of medicine (triamcinolone acetonide acetates of 6%ARB+2%L-733060+1%DALBK (or HOE-140)+2%).
Matrix and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate are pasted by changing bar cloth
Quality proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration
Triamcinolone acetonide) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (2%ARB+2%L-733060+1%DALBK (or HOE-140)+1% of embodiment 136 6%
Triamcinolone acetonide acetate) anti-scar spray preparation method
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example:In 100g physiological saline
In, 2g Losartan Potassiums, 2g L-733060,1g DALBK (or HOE-140) and 1g triamcinolone acetonide acetates and 1g urea are added, is filled
Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate
Quality proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration
Triamcinolone acetonide) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 137 0.5% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140) Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:70
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs
Uniformly it is used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea
10g dissolvings are used as aqueous phase;100mg Irbesartans, 100mg L-733060,100mg DALBK (or HOE- are weighed with electronic balance
140), 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, Irbesartan, L-733060, DALBK (or HOE-140), vinegar
Sour Triamcinolone acetonide, Bulbus Allii Cepae extract add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed
It is stored in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE class medicines (0.1%ARB+0.1%L-733060+0.1%
The Bulbus Allii Cepae extract of DALBK (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea.
By change Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 138 14% (2%ARB+1%L-733060+6%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:70
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs
Uniformly it is used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea
10g dissolvings are used as aqueous phase;2g Irbesartans, 1g L-733060,6g DALBK (or HOE-140), 2g oceans are weighed with electronic balance
Herba Alii fistulosi extract and 1g triamcinolone acetonide acetates, Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, onion
Extract adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5
In DEG C refrigerator.Above method obtains 14% compound ACE classes medicine (2%ARB+1%L-733060+6%DALBK (or HOE-140)
The Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By change Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 139 10% (2%ARB+2%L-733060+2%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:70
By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g in DEG C water bath with thermostatic control
100ml beakers are put into, heating and melting simultaneously stirs as oil phase;Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL, glycerine 10ml,
Lauryl sodium sulfate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;Weighed with electronic balance
2g Irbesartans, 2g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts and 2g triamcinolone acetonide acetates, E Bei
Sha Tan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving;Finally by aqueous phase
Oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 10% compound ACE class medicines
Thing (Bulbus Allii Cepae extract of 2%ARB+2%L-733060+2%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+2%) is containing more
The kind anti-scar ointment of emulsifying agent.
By change Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and
The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 140 20% (4%ARB+4%L-733060+4%DALBK (or HOE-140)+
The Bulbus Allii Cepae extract of 4% triamcinolone acetonide acetate+4%) anti-scar normal saline solution preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Room temperature
Under the conditions of, weigh 100g normal saline solutions, with electronic balance weigh 4g Irbesartans, 4g L-733060,4g DALBK (or
HOE-140), 4g Bulbus Allii Cepae extracts and 4g triamcinolone acetonide acetates, which are added in physiological saline, is sufficiently stirred.Encapsulation preserves.Above method
Obtain 20% compound ACE classes medicine (triamcinolone acetonide acetates of 4%ARB+4%L-733060+4%DALBK (or HOE-140)+4%+
4% Bulbus Allii Cepae extract) anti-scar normal saline solution.
By changing physiological saline and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean
Herba Alii fistulosi extract quality proportioning can obtain 0.05-25% concentration 0.4% compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar normal saline solution, with for different type scar or acquirement
Optimal anti-scar effect.
The compound ACE classes medicine (1%ARB+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 141 5%
The Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%) anti-scar gel preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Room temperature
Under the conditions of, 72g normal saline solutions are weighed, add 1g Irbesartans, 1g L-733060,1g DALBK (or HOE-140), 1g
Bulbus Allii Cepae extract and 1g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.
It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 5% compound ACE class medicines (1%ARB+1%L-
The Bulbus Allii Cepae extract of 733060+1%DALBK (or HOE-140)+1% triamcinolone acetonide acetate+1%) anti-scar gel.
By changing physiological saline and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean
The quality proportioning of Herba Alii fistulosi extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar gel, for different type scar or to obtain optimal anti-scar
Trace effect.
The compound ACE classes medicine of embodiment 142 0.5% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140) Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar plastics preparation method
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:Weigh
8g polyvinyl alcohol (PVA) is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, adds
3ml glycerine, stir to well mixed.Be eventually adding 100mg Irbesartans, 100mg L-733060,100mg DALBK (or
HOE-140), 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, are stirred well to and are completely dissolved, be cooled to room temperature.Envelope
Dress preserves.
By change plastics matrix and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and
The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics, for different type scar or to obtain optimal anti-
Scar effect.
The compound ACE classes medicine of embodiment 143 11% (1%ARB+3%L-733060+3%DALBK (or
HOE-140) the Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+3%) anti-scar bar cloth patch preparation method
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:50
In DEG C water bath with thermostatic control, 1g Irbesartans, 3g L-733060,3g DALBK (or HOE-140), 3g Bulbus Allii Cepae extracts and 1g vinegar are taken
Sour Triamcinolone acetonide, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums,
0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;Finally
A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With
Upper method obtains 11% compound ACE classes medicine, and (acetic acid of 1%ARB+3%L-733060+3%DALBK (or HOE-140)+1% is bent
The Bulbus Allii Cepae extracts of An Naide+3%) anti-scar bar cloth patch.
By change bar cloth paste matrix and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and
The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-
Scar effect.
The compound ACE classes medicine of embodiment 144 0.5% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140) Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar spray preparation method
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example:
In 100g physiological saline, 100mg Irbesartans, 100mg L-733060,100mg DALBK (or HOE-140), 100mg are added
Bulbus Allii Cepae extract and 100mg triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and
The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or
HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar spray, for different type scar or to obtain optimal anti-
Scar effect.
The compound ACE classes medicine of embodiment 145 0.6% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140) liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control
And stir as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add
Urea 10g dissolvings are used as aqueous phase;With electronic balance weigh 100mg Valsartans, 100mg L-733060,100mg DALBK (or
HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, Valsartan, L-733060, DALBK
(or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally aqueous phase oil phase is mixed and filled
Divide stirring to be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 0.6% compound ACE class medicines (0.1%ARB+
The liver of+0.1% Bulbus Allii Cepae extract of 0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1%
Plain sodium) the anti-scar ointment containing urea.
Carried by changing Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion
The ratio of thing and ointment bases is taken to obtain the compound ACE classes medicine (Valsartan+L-733060+ of 0.05-25% mass fractions
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 146 16% (2%ARB+6%L-733060+2%DALBK (or HOE-140)+
The liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control
And stir as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add
Urea 10g dissolvings are used as aqueous phase;2g Valsartans, 6g L-733060,2g DALBK (or HOE-140), 2g are weighed with electronic balance
Bulbus Allii Cepae extract, 2g triamcinolone acetonide acetates and 2g liquaemins, Valsartan, L-733060, DALBK (or HOE-140), acetic acid Qu An
Nai De, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring extremely
Room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 16% compound ACE class medicines (2%ARB+6%L-733060+2%
The liquaemin of+2% Bulbus Allii Cepae extract of DALBK (or HOE-140)+2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
Carried by changing Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion
The ratio of thing and ointment bases is taken to obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% mass fractions
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ARB+2%L-733060+1%DALBK (or HOE-140)+2% of embodiment 147 8%
The liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) the anti-scar ointment containing numerous emulsifiers preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, nipalgin in 70 DEG C of waters bath with thermostatic control
Ethyl ester 0.3g is put into 100ml beakers, and heating and melting simultaneously stirs as oil phase;Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL,
Glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase;Use electronics
Balance weighs 1g Valsartans, 2g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates
With 1g liquaemins, Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add
Enter oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.With top
Method obtains the 8% compound ACE classes medicine (triamcinolone acetonide acetates of 1%ARB+2%L-733060+1%DALBK (or HOE-140)+2%
The liquaemin of+1% Bulbus Allii Cepae extract+1%) the anti-scar ointment containing numerous emulsifiers.
Carried by changing Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion
The ratio of thing and ointment bases is taken to obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% mass fractions
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 148 13% (2%ARB+1%L-733060+1%DALBK (or HOE-140)+
The liquaemin of+3% Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+3%) anti-scar normal saline solution preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Under room temperature condition, 100g normal saline solutions are weighed, 2g Valsartans, 1g L-733060,1g are weighed with electronic balance
DALBK (or HOE-140), 3mg Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 3g liquaemins are added in physiological saline and fully stirred
Mix.Encapsulation preserves.Above method obtains 13% compound ACE classes medicine (2%ARB+1%L-733060+1%DALBK (or HOE-
140) liquaemin of+3% Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+3%) anti-scar normal saline solution.
By changing physiological saline and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, heparin
Sodium and Bulbus Allii Cepae extract quality proportioning can obtain the compound ACE class medicines (ARB+L-733060+DALBK of 0.05-25% concentration
(or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar normal saline solution, with for different type
Scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 149 0.6% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140) liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar gel preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Under room temperature condition, 72g normal saline solutions are weighed, add 100mg Valsartans, 100mg L-733060,100mg DALBK
(or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins fully dissolve, and add 3g carboxylics
Sodium carboxymethylcellulose pyce, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains
To 0.6% compound ACE classes medicine, (acetic acid of 0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% is bent
The liquaemin of the Bulbus Allii Cepae extracts of An Naide+0.1%+0.1%) anti-scar gel.
By changing physiological saline and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, heparin
The quality proportioning of sodium and Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+DALBK of 0.05-25% concentration
(or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar gel, for different type scar or to take
Obtain most preferably anti-scar effect.
The compound ACE classes medicine of embodiment 150 22% (6%ARB+2%L-733060+4%DALBK (or HOE-140)+
The liquaemin of+4% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+4%) anti-scar plastics preparation method
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, be stirred well to and be completely dissolved in 90 DEG C of waters bath with thermostatic control,
3ml glycerine is added, is stirred to well mixed.It is eventually adding 6g Valsartans, 2g L-733060,4g DALBK (or HOE-
140), 4g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 4g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation
Preserve.
By changing plastics matrix and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver
The quality proportioning of plain sodium and Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar plastics, with for different type scar
Trace obtains optimal anti-scar effect.
The compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% of embodiment 151 9%
The liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%+1%) anti-scar bar cloth patch preparation method
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:In 50 DEG C of waters bath with thermostatic control, take 1g Valsartans, 2g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts,
1g triamcinolone acetonide acetates and 1g liquaemins, are dissolved in 80g distilled water, and 2.5g carbomers, 5g glycerine, 2.5g are added into the aqueous solution
Gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirring is equal
It is even, obtain B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covered
Adherent layer, stripping and slicing.Above method obtains 9% compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-
140) liquaemin of+2% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch.
Matrix and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver are pasted by changing bar cloth
Plain sodium, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar bar cloth patch, with for different type scar
Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 152 14% (3%ARB+2%L-733060+3%DALBK (or HOE-140)+
The liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+3%) anti-scar spray preparation method
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as
Example:In 100g physiological saline, 3g Valsartans, 2g L-733060,3g DALBK (or HOE-140), the extraction of 2g onions are added
Thing, 1g triamcinolone acetonide acetates and 3g liquaemins and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver
The quality proportioning of plain sodium and Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar spray, with for different type scar
Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 153 24% (2%ARB+2%L-733060+4%DALBK (or HOE-140)+
The asiaticosid of+4% liquaemin of+4% Bulbus Allii Cepae extract of 6% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn
Cup, heating are melted and stirred as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to
70 DEG C, add urea 10g dissolvings and be used as aqueous phase;2g Telmisartans, 2g L-733060,4gDALBK are weighed with electronic balance
(or HOE-140), 4g Bulbus Allii Cepae extracts, 6g triamcinolone acetonide acetates, 2g asiaticosids and 4g liquaemins, Telmisartan, L-
733060th, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;
Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 24%
(onion of 2%ARB+2%L-733060+4%DALBK (or HOE-140)+6% triamcinolone acetonide acetate+4% carries square ACE classes medicine
Take the asiaticosid of the liquaemin of thing+4%+2%) the anti-scar ointment containing urea.
By changing Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ARB+L- of 0.05-25% mass fractions
733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea
Ointment.
The compound ACE classes medicine of embodiment 154 0.7% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-
140) asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar containing urea
The preparation of ointment
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn
Cup, heating are melted and stirred as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to
70 DEG C, add urea 10g dissolvings and be used as aqueous phase;With electronic balance weigh 100mg Telmisartans, 100mg L-733060,
100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg asiaticosids and 100mg
Liquaemin, Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and product
Asiaticoside adds oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5
In DEG C refrigerator.Above method obtain 0.7% compound ACE classes medicine (0.1%ARB+0.1%L-733060+0.1%DALBK (or
HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) resist containing urea
Scar ointment.
By changing Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ARB+L- of 0.05-25% mass fractions
733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea
Ointment.
The compound ACE classes medicine (1%ARB+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 155 7%
The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) the anti-scar ointment containing numerous emulsifiers preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine in 70 DEG C of waters bath with thermostatic control
16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs as oil phase;Steaming is taken in 70 DEG C of waters bath with thermostatic control
Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as water
Phase;1g Telmisartans, 1g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g vinegar are weighed with electronic balance
Sour Triamcinolone acetonide, 1g asiaticosids and 1g liquaemins, Telmisartan, L-733060, DALBK (or HOE-140), acetic acid Qu An how
Moral, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to
Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 7% compound ACE class medicines (1%ARB+1%L-733060+1%
The asiaticosid of+1% liquaemin of DALBK (or HOE-140)+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) contain a variety of breasts
The anti-scar ointment of agent.
By changing Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver
The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ARB+L- of 0.05-25% mass fractions
733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) contain numerous emulsifiers
Anti- scar ointment.
The compound ACE classes medicine (2%ARB+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 156 8%
The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) anti-scar normal saline solution preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Under room temperature condition, 100g normal saline solutions are weighed, 2g Telmisartans, 1g L- are weighed with electronic balance
733060th, 1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins add
Enter in physiological saline and be sufficiently stirred.Encapsulation preserves.Above method obtains 8% compound ACE class medicines (2%ARB+1%L-733060
The asiaticosid of+1% liquaemin of+1%DALBK (or HOE-140)+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) anti-scar
Trace normal saline solution.
By changing physiological saline and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean
Herba Alii fistulosi extract, liquaemin and asiaticosid quality proportioning can obtain the compound ACE class medicines (ARB+L- of 0.05-25% concentration
733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar physiology salt
The aqueous solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 157 18% (2%ARB+2%L-733060+2%DALBK (or HOE-140)+
The asiaticosid of+2% liquaemin of+6% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) anti-scar gel preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:Under room temperature condition, 72g normal saline solutions are weighed, add 2g Telmisartans, 2g L-733060,2g
DALBK (or HOE-140), 6g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins fully dissolve, then
3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With
Upper method obtains 18% compound ACE classes medicine, and (acetic acid of 2%ARB+2%L-733060+2%DALBK (or HOE-140)+2% is bent
The asiaticosid of+2% liquaemin of the Bulbus Allii Cepae extracts of An Naide+6%+2%) anti-scar gel.
By changing physiological saline and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean
The compound ACE classes medicine that the quality proportioning of Herba Alii fistulosi extract, liquaemin and asiaticosid can obtain 0.05-25% concentration (replaces meter Sha
Smooth+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar coagulates
Glue, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 158 14% (3%ARB+1%L-733060+2%DALBK (or HOE-140)+
The asiaticosid of+2% liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+3%) anti-scar plastics preparation method
By taking Telmisartan+L-733060+DALBK (or HOE-140) as an example:8g polyvinyl alcohol (PVA) is weighed to be added to
In 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.
How it is eventually adding 3g Telmisartans, 1g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 1g acetic acid Qu An
Moral, 3g asiaticosids and 2g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ARB+ of 0.05-25% concentration
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar film
Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 159 15% (2%ARB+4%L-733060+1%DALBK (or HOE-140)+
The asiaticosid of+1% liquaemin of+2% Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+2%) anti-scar bar cloth patch preparation method
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:In 50 DEG C of waters bath with thermostatic control, 2g Telmisartans, 4g L-733060,1g DALBK (or HOE-140), 2g are taken
Bulbus Allii Cepae extract, 3g triamcinolone acetonide acetates, 2g asiaticosids and 1g liquaemins, are dissolved in 80g distilled water, are added into the aqueous solution
2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added
Into 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room
Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 15% compound ACE class medicines (2%ARB+4%L-
The centella of+1% liquaemin of 733060+1%DALBK (or HOE-140)+2% Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+2%
Glycosides) anti-scar bar cloth patch.
By change bar cloth paste matrix and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ARB+ of 0.05-25% concentration
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar bar cloth
Patch, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% of embodiment 160 9%
The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) anti-scar spray preparation method
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+
Exemplified by asiaticosid:In 100g physiological saline, add 1g Telmisartans, 2g L-733060,2g DALBK (or HOE-140),
1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins and 1g urea, are stirred.And load
In spray bottle.
By change spray reclaimed water and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate,
The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ARB+ of 0.05-25% concentration
L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) spraying of anti-scar
Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 161 5% (asiaticosid of 3%Ang 1-7+1% triamcinolone acetonide acetates+1%) is anti-
The preparation of scar gel
By taking Ang 1-7+ triamcinolone acetonide acetates+asiaticosid as an example:Under room temperature condition, 72g normal saline solutions are weighed, are added
Enter 3g Ang 1-7,1g triamcinolone acetonide acetates, 1g asiaticosids fully to dissolve, add 3g sodium carboxymethylcelluloses, 25 DEG C of bars
It is swelled overnight under part.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 5% compound ACE class medicines
(asiaticosid of 3%Ang 1-7+1% triamcinolone acetonide acetates+1%) anti-anti- scar gel of scar gel.
By change physiological saline and Ang 1-7, triamcinolone acetonide acetate, asiaticosid quality proportioning can obtain 0.05-
Compound ACE classes medicine (Ang 1-7, triamcinolone acetonide acetate, asiaticosid) anti-scar gel of 25% concentration, with for inhomogeneity
Type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+3% of 3%Ang 1-7+1% asiaticosids+3% of embodiment 162 10%
Liquaemin) anti-scar plastics preparation method
By taking Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract+heparin as an example:Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml
In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally
3g Ang 1-7,1g asiaticosids, 3g Bulbus Allii Cepae extracts and 3g liquaemins are added, is stirred well to and is completely dissolved, be cooled to room
Temperature.Encapsulation preserves.
It can be obtained by the quality proportioning for changing plastics matrix and Ang 1-7, asiaticosid, Bulbus Allii Cepae extract and liquaemin
To compound ACE classes medicine (Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract+liquaemin) anti-scar film of 0.05-25% concentration
Agent, with for different type scar or the optimal anti-scar effect of acquirement.
Embodiment 163 10% compound ACE classes medicine (liquaemin of 2%L-733060+2% Bulbus Allii Cepae extracts+6%) anti-scar
Trace bar cloth pastes preparation method
L-733060+ Bulbus Allii Cepae extracts+liquaemin:In 50 DEG C of waters bath with thermostatic control, 2g L-733060, the extraction of 2g onions are taken
Thing, 6g liquaemins, are dissolved in 80g distilled water, and 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peaches are added into the aqueous solution
Glue, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid;
Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, adherent layer is covered, cuts
Block.Above method obtains 10% compound ACE classes medicine (liquaemin of 2%L-733060+2% Bulbus Allii Cepae extracts+6%) anti-scar bar
Cloth pastes.
By change bar cloth paste matrix and L-733060, Bulbus Allii Cepae extract, liquaemin quality proportioning can obtain 0.05-
The anti-scar bar cloth patch of compound ACE classes medicine (L-733060+ Bulbus Allii Cepae extracts+liquaemin) of 25% concentration, with for inhomogeneity
Type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (triamcinolone acetonide acetate of 5%L-733060+5% asiaticosids+15%) of embodiment 164 25%
Anti- scar spray preparation method
By taking L-733060+ asiaticosids+triamcinolone acetonide acetate as an example:In 100g physiological saline, 5g L- are added
733060th, 5g asiaticosids and 15g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and L-733060, asiaticosid, triamcinolone acetonide acetate quality proportioning can obtain
Compound ACE classes medicine (L-733060+ asiaticosids+triamcinolone acetonide acetate) anti-scar spray of 0.05-25% concentration, with pin
To different type scar or obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 165 0.4% (asiaticosids of 0.1%DALBK (or HOE-140)+0.1%+
The Bulbus Allii Cepae extract of 0.1% liquaemin+0.1%) the anti-scar ointment containing urea preparation
With DALBK (or HOE-140)+asiaticosid+liquaemin+Bulbus Allii Cepae extract:By tristearin in 70 DEG C of waters bath with thermostatic control
Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase;70 DEG C of perseverances
Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase;Electricity consumption
Sub- balance weighs 100mg DALBK (or HOE-140), 100mg asiaticosids, 100mg liquaemins, 100mg Bulbus Allii Cepae extracts,
DALBK (or HOE-140), asiaticosid, liquaemin, Bulbus Allii Cepae extract add oil phase dissolving;Finally aqueous phase oil phase is mixed simultaneously
It is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE classes medicine (0.1%
The Bulbus Allii Cepae extract of+0.1% liquaemin of DALBK (or HOE-140)+0.1% asiaticosid+0.1%) the anti-scar ointment containing urea.
Can by the ratio for changing DALBK (or HOE-140), asiaticosid, liquaemin, Bulbus Allii Cepae extract and ointment bases
To obtain the compound ACE classes medicine (ADALBK (or HOE-140)+asiaticosid+liquaemin+onion of 0.05-25% mass fractions
Extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 166 15% (extract by the onion of 5%DALBK (or HOE-140)+5% liquaemin+5%
Thing) the anti-scar ointment containing numerous emulsifiers preparation
By taking DALBK (or HOE-140)+liquaemin+Bulbus Allii Cepae extract as an example:By stearic acid in 70 DEG C of waters bath with thermostatic control
4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating is melted
Change and stir as oil phase;Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add in 70 DEG C of waters bath with thermostatic control
Enter to be heated to 70 DEG C in 100ml beakers and be well mixed to be used as aqueous phase;With electronic balance weigh 5g DALBK (or HOE-140),
5g Bulbus Allii Cepae extracts and 5g liquaemins, DALBK (or HOE-140), liquaemin and Bulbus Allii Cepae extract add oil phase dissolving;Finally will
Aqueous phase oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 15% compound ACE
Class medicine (Bulbus Allii Cepae extract of 5%DALBK (or HOE-140)+5% liquaemin+5%) anti-scar ointment containing numerous emulsifiers.
It can be obtained by the ratio for changing DALBK (or HOE-140), liquaemin, Bulbus Allii Cepae extract and ointment bases
The compound ACE classes medicine (DALBK (or HOE-140)+liquaemin+Bulbus Allii Cepae extract) of 0.05-25% mass fractions resists containing urea
Scar ointment.
The compound ACE classes medicine (asiaticosid of 3%AcSDKP+9% triamcinolone acetonide acetates+9%) of embodiment 167 21% is anti-
The preparation of scar normal saline solution
By taking AcSDKP+ triamcinolone acetonide acetates+asiaticosid as an example:Under room temperature condition, 100g normal saline solutions are weighed, are used
Electronic balance weighs 3g AcSDKP, 9g triamcinolone acetonide acetates, 9g asiaticosids and adds in physiological saline and be sufficiently stirred.Encapsulation is protected
Deposit.Above method obtains 21% compound ACE classes medicine (asiaticosid of 3%AcSDKP+9% triamcinolone acetonide acetates+9%) anti-scar
Normal saline solution.
0.05-25% is can obtain by changing physiological saline and AcSDKP, triamcinolone acetonide acetate, asiaticosid quality proportioning
Compound ACE classes medicine (AcSDKP+ triamcinolone acetonide acetates+asiaticosid) anti-scar normal saline solution of concentration, with for not
Same type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 168 3.5% (asiaticosid of 0.5%AcSDKP+0.5% Bulbus Allii Cepae extracts+1%+
1.5% liquaemin) anti-scar gel preparation
By taking AcSDKP+ Bulbus Allii Cepae extracts+asiaticosid+liquaemin as an example:Under room temperature condition, it is water-soluble to weigh 72g physiology salts
Liquid, add 0.5g AcSDKP, 0.5g Bulbus Allii Cepae extracts, 1g asiaticosids, 1.5g liquaemins and fully dissolve, add 3g carboxylic first
Base sodium cellulosate, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains
3.5% compound ACE classes medicine (liquaemin of+1% asiaticosid of 0.5%AcSDKP+0.5% Bulbus Allii Cepae extracts+1.5%) anti-scar
Gel.
By change physiological saline and AcSDKP, Bulbus Allii Cepae extract, asiaticosid, liquaemin quality proportioning can obtain
Compound ACE classes medicine (AcSDKP+ Bulbus Allii Cepae extracts+asiaticosid+liquaemin) anti-scar gel of 0.05-25% concentration, with
For different type scar or obtain optimal anti-scar effect.
Compound ACE classes medicine (the 0.1%ARB+0.1%L-733060+0.1% liquaemins+0.1% of embodiment 169 0.4%
Bulbus Allii Cepae extract) anti-scar plastics preparation method
By taking Telmisartan+L-733060+ liquaemins+Bulbus Allii Cepae extract as an example:8g polyvinyl alcohol (PVA) is weighed to be added to
In 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.
100mg Telmisartans, 100mg L-733060,100mg liquaemins and 100mg Bulbus Allii Cepae extracts are eventually adding, is stirred well to
It is completely dissolved, is cooled to room temperature.Encapsulation preserves.
Can by the quality proportioning for changing plastics matrix and Telmisartan, L-733060, liquaemin and Bulbus Allii Cepae extract
The anti-scar of compound ACE classes medicine (Telmisartan+L-733060+ liquaemins+Bulbus Allii Cepae extract) for obtaining 0.05-25% concentration applies
Film, with for different type scar or the optimal anti-scar effect of acquirement.
Compound ACE classes medicine (the 4%ARB+4%L-733060+4% triamcinolone acetonide acetates+12% of embodiment 170 24%
Asiaticosid) anti-scar bar cloth patch preparation method
By taking Irbesartan+L-733060+ triamcinolone acetonide acetates+asiaticosid as an example:In 50 DEG C of waters bath with thermostatic control, take 4g in distress
Bei Shatan, 4g L-733060,4g triamcinolone acetonide acetates and 12g asiaticosids, are dissolved in 80g distilled water, are added into the aqueous solution
2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid;4g Sodium Polyacrylates separately are taken, are added
Into 4g glycerine, dissolving stirs, and obtains B liquid;Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room
Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 24% compound ACE class medicines (4%ARB+4%L-
The asiaticosid of 733060+4% triamcinolone acetonide acetates+12%) anti-scar bar cloth patch.
The quality proportioning of matrix and Irbesartan, L-733060, triamcinolone acetonide acetate, asiaticosid is pasted by changing bar cloth
The compound ACE classes medicine (Irbesartan+L-733060+ triamcinolone acetonide acetates+asiaticosid) that can obtain 0.05-25% concentration is anti-
Scar bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 171 0.6% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or
HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract+0.1%) anti-scar spray preparation method
By taking lisinopril+L-733060+DALBK (or HOE-140)+asiaticosid+Bulbus Allii Cepae extract+liquaemin as an example:
In 100g physiological saline, add 100mg lisinoprils, 100mg L-733060,100mg DALBK (or HOE-140),
100mg asiaticosids, 100mg Bulbus Allii Cepae extracts, 100mg liquaemins and 1g urea, are stirred.And load spray bottle
In.
By changing spray reclaimed water and lisinopril, L-733060, DALBK (or HOE-140), asiaticosid, onion
Extract, the quality proportioning of liquaemin can obtain the compound ACE classes medicine (lisinopril+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+asiaticosid+Bulbus Allii Cepae extract+liquaemin) anti-scar spray, with for different type scar or
Obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 172 24% (9%ACEI+3%L-733060+6%DALBK (or HOE-140)+
The liquaemin of 3% Bulbus Allii Cepae extract+3%) the anti-scar ointment containing urea preparation
By taking captopril+L-733060+DALBK (or HOE-140)+Bulbus Allii Cepae extract+liquaemin as an example:In 70 DEG C of constant temperature
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing and the work that stirs in water-bath
For oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings
As aqueous phase;9g captoprils, 3g L-733060,6g DALBK (or HOE-140), 3g onions are weighed with electronic balance to extract
Thing and 3g liquaemins, captopril, L-733060, DALBK (or HOE-140), Bulbus Allii Cepae extract, liquaemin addition oil phase are molten
Solution;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains
The 24% compound ACE classes medicine (liver of 9%ACEI+3%L-733060+6%DALBK (or HOE-140)+3% Bulbus Allii Cepae extract+3%
Plain sodium) the anti-scar ointment containing urea.
By changing captopril, L-733060, DALBK (or HOE-140), Bulbus Allii Cepae extract, liquaemin and ointment base
The ratio of matter can obtain 0.05-25% mass fractions compound ACE classes medicine (captopril+L-733060+DALBK (or
HOE-140)+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 173 14% (2%ACEI+6%L-733060+2%DALBK (or HOE-140)+
The asiaticosid of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+asiaticosid as an example:At 70 DEG C
Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in water bath with thermostatic control, heating is melted and stirred
It is even to be used as oil phase;Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g
Dissolving is used as aqueous phase;2g Ramiprils, 6g L-733060,2g DALBK (or HOE-140), 2g acetic acid are weighed with electronic balance
Triamcinolone acetonide, 2g asiaticosids, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, asiaticosid
Add oil phase dissolving;The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators
In.Above method obtains 14% compound ACE classes medicine (2%ACEI+6%L-733060+2%DALBK (or HOE-140)+2%
The asiaticosid of triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, asiaticosid and soft
The ratio of cream base matter can obtain the compound ACE classes medicine (Ramipril+L-733060+DALBK of 0.05-25% mass fractions
(or HOE-140)+triamcinolone acetonide acetate+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 174 13% (1%ARB+2%L-733060+1%DALBK (or HOE-140)+
The liquaemin of+1% Bulbus Allii Cepae extract of 3%AcSDKP+2%Ang 1-7+2% asiaticosids+1%) the anti-scar containing numerous emulsifiers is soft
The preparation of cream
With Valsartan+L-733060+DALBK (or HOE-140)+AcSDKP+Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract
Exemplified by+liquaemin:By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine in 70 DEG C of waters bath with thermostatic control
16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs as oil phase;Steaming is taken in 70 DEG C of waters bath with thermostatic control
Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as water
Phase;1g Valsartans, 2g L-733060,1g DALBK (or HOE-140), 3g AcSDKP, 2g Ang 1- are weighed with electronic balance
7th, 2g asiaticosids, 1g Bulbus Allii Cepae extracts, 1g liquaemins, Valsartan, L-733060, DALBK (HOE-140), AcSDKP, Ang
1-7, asiaticosid, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving;Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to
Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 13% compound ACE class medicines (1%ARB+2%L-733060+1%
The liquaemin of+1% Bulbus Allii Cepae extract of DALBK (or HOE-140)+3%AcSDKP+2%Ang 1-7+2% asiaticosids+1%) contain
The anti-scar ointment of numerous emulsifiers.
By changing Valsartan, L-733060, DALBK (HOE-140), AcSDKP, Ang 1-7, asiaticosid, onion carry
The ratio of thing, liquaemin and ointment bases is taken to obtain the compound ACE classes medicine (Valsartan+L- of 0.05-25% mass fractions
733060+DALBK (or HOE-140)+AcSDKP+Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract+liquaemin) contain a variety of emulsifications
The anti-scar ointment of agent.
The compound ACE classes medicine of embodiment 175 21% (3%ARB+2%L-733060+1%DALBK (or HOE-140)+
The liquaemin of 3%AcSDKP+6%Ang 1-7+3% Bulbus Allii Cepae extracts+3%) anti-scar normal saline solution preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+AcSDKP+Ang 1-7+ Bulbus Allii Cepae extracts+liquaemin
Exemplified by:Under room temperature condition, weigh 100g normal saline solutions, with electronic balance weigh 3g Telmisartans, 2g L-733060,
1gDALBK (or HOE-140), 3g AcSDKP, 6g Ang 1-7,3g Bulbus Allii Cepae extracts, 3g liquaemins, which are added in physiological saline, to be filled
Divide stirring.Encapsulation preserves.Above method obtain 21% compound ACE classes medicine (3%ARB+2%L-733060+1%DALBK (or
HOE-140) the liquaemin of+3%AcSDKP+6%Ang 1-7+3% Bulbus Allii Cepae extracts+3%) anti-scar normal saline solution.
By change physiological saline and Telmisartan, L-733060, DALBK (or HOE-140), AcSDKP, Ang 1-7,
Bulbus Allii Cepae extract, liquaemin quality proportioning can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration
DALBK (or HOE-140)+AcSDKP+Ang 1-7+ Bulbus Allii Cepae extracts+liquaemin) anti-scar normal saline solution, with for not
Same type scar obtains optimal anti-scar effect.
The detection of each ACE related activities peptide in the mouse scar of embodiment 176
1. experimental method:
(1) experimental subjects:Select C57BL/6 mouse, be divided into 4 groups, respectively K groups be ACE gene knockouts group, R groups be thunder
Meter Pu Li groups, H groups are hydralazine group, B groups are blank control group.Wherein K groups use ACE knock out mice, remaining each group
It is the wild type with the compatriot's birth of ACE knock out mice.
(2) factor is handled:
After mouse conventinal breeding 3d, in the chloraldurate normal saline solution 0.1ml/10g of intraperitoneal injection 4%, anaesthetize into
The hair of dorsal area is cut off after work(with scissors, depilatory cream further removes the hair of mouse back.Using mouse backbone as center line, side is opened
Surgically left and right respectively cuts off 1 piece of 2mm × 15mm stringer rectangular slits (Fig. 2) to 4mm.Cage is divided to feed mouse after otch foundation
Support, add different medicines respectively in mouse drinking water, wherein B groups feed common drinking water;R groups, which are fed, contains Ramipril
The drinking water of (10mg/kg/ days);H groups feed the drinking water containing hydralazine (40mg/kg/ days);D groups feed common drinking water.Treat
Mouse is put to death after all mouse back operative incision surface scabs come off within postoperative 14 days.Cicatricial tissue, FFPE are cut, row is exempted from
Ang II, SP and Ang 1-7 expression quantity in epidemic disease groupization detection tissue;Take part cicatricial tissue ELISA method detection AcSDKP
Expression quantity.
2. experimental result:
(1) Ang II ImmunohistochemistryResults Results
Each group ImmunohistochemistryResults Results are shown in Fig. 3, as seen from the figure, the Ang II expression of ACE gene knockouts group and Ramipril group
Amount is significantly lower than hydralazine group and blank control group (p<0.05);But ACE gene knockouts group and Ramipril group difference are without system
Meter learns meaning (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
(2) SP ImmunohistochemistryResults Results
Each group ImmunohistochemistryResults Results are shown in Fig. 4, and as seen from the figure, the SP expression quantity of ACE gene knockouts group and Ramipril group is bright
It is aobvious to be higher than hydralazine group and blank control group (p<0.05);But ACE gene knockouts group and Ramipril group no statistical difference
Meaning (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
(3) Ang 1-7 ImmunohistochemistryResults Results
Each group ImmunohistochemistryResults Results are shown in Fig. 5, as seen from the figure, the Ang 1-7 expression of ACE gene knockouts group and Ramipril group
Measure apparently higher than hydralazine group and blank control group (p<0.05);But ACE gene knockouts group and Ramipril group difference are without system
Meter learns meaning (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
(4) ImmunohistochemistryResults Results
Average gray (average optical density) result using ImageJ software quantitative analyses Ang II, SP and Ang 1-7 is shown in
Fig. 6.Ang II expression quantity in ACE gene knockouts group, Ramipril group cicatricial tissue is significantly lower than blank control group and hydrazine benzene
Pyridazine group (p<0.05), and SP and Ang 1-7 expression quantity is apparently higher than blank control group and hydralazine group (p<0.05).
(4) AcSDKP ELISA experimental results
Each group ELISA experimental results are shown in Fig. 7.The AcSDKP expression quantity of ACE gene knockouts group and Ramipril group is substantially high
In hydralazine group and blank control group (p<0.05);But ACE gene knockouts group and Ramipril group no significant difference
(p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
3. experiment conclusion:
(1) ACE is blocked to reduce cicatricial tissue Ang II expression by way of medicine or gene knockout.
(2) ACE is blocked to increase cicatricial tissue SP, Ang 1-7 and AcSDKP by way of medicine or gene knockout
Expression.
The optium concentration of embodiment 177ACE related activities peptide/inhibitor (ACE classes medicine) stimulated in vitro
1. experimental method:
Using the DMEM cell culture fluid culture NIH 3T3 l cells containing 10%FBS, (fibroblast is
The ultimate effector cell of cicatrization, other cells and factor are all finally by influenceing wound to fibroblastic effect
Healing), but FBS was reduced to 1% to reduce the influence of various albumen in serum as far as possible in 24 hours before detection.Will
NIH 3T3 fibroblasts (DMEM containing 1%FBS) are transferred to 96 orifice plates, and adding 1ng/ml TGF-βs 1 stimulates (TGF-β 1
It is the strong rush fibrosis factor, adding the restructuring TGF-β 1 of external source stimulates cell to simulate wound stimulation) pierced with simulating wound
Swash;The Ang II, SP, AcSDKP, Ang1-7 and bradykinin of at least 3 various concentrations (10 times are incremented by) are separately added into simultaneously, with
And respective inhibitor (or antagonist) and ACE inhibitor.48 hours, using CCK-8 methods (CellCounting Kit-8,
Dojindo, Japan) detection cell proliferative conditions.
According to the action principle of each medicine, if selected medicine plays a driving role in NIH3T3 cells propagation, more
No cytotoxicity is selected in individual concentration, promotes the optimal least concentration of cell cultivation effect as optium concentration;If selected medicine
Inhibitory action is played in NIH3T3 cells propagation, then no cytotoxicity is selected in multiple concentration, suppresses cell cultivation effect most
Good least concentration is as optium concentration.
2. experimental result
Experimental result is shown in Table 1.
The optium concentration of the ACE related activities peptide of table 1 and inhibitor stimulated in vitro
Biologically active peptide | Optium concentration | Inhibitor | Optium concentration |
AngII | 10nM | Losartan | 100μM |
SP | 100nM | L-733060 | 1μM |
Ang1-7 | 10nM | A779 | 10μM |
AcSDKP | 1×10-4mg/ml | S-17092 | 1×10-2mg/ml |
Bradykinin | 1nM | DALBK | 10nM |
HOE-140 | 100nM | ||
Lisinopril | 10μM |
The ACE class drug influence NIH 3T3 cells of embodiment 178 are bred and the experimental study of collagen
The final result of cicatrization shows hyperblastosis and collagen deposition in vivo, then finally shows thin in vitro
Born of the same parents breed and collagen production.
1. experimental method:
Using the DMEM cell culture fluid culture NIH 3T3 l cells containing 10%FBS, but before detection
FBS was reduced to 1% influence for having reduced various albumen in serum as far as possible in 24 hours.1ng/ml TGF-βs 1 are added to simulate
Wound stimulates;While Ang II are separately added into, SP, AcSDKP, Ang 1-7 and bradykinin, and respective inhibitor (or antagonism
Agent) and ACE inhibitor, the concentration of each active peptide and inhibitor (or antagonist) is all optimal dense in above-described embodiment
Degree;After culture 48 hours, using CCK-8 methods (Cell Counting Kit-8, Dojindo, Japan) detection cell propagation feelings
Condition, the collagen egg in nutrient solution is detected with Sirius Red Collagen Detection Kit (Chondres Inc.USA)
White concentration.Above-mentioned every kind of ACE classes medicine does 6 repetitions, and the data of acquisition carry out single factor test using the SPSS19.0 of IBM Corporation
Variance analysis, compare two-by-two using LSD methods, p<0.05 thinks statistically significant.
2. experimental result:
Cell proliferative conditions are shown in Fig. 8.Because cell proliferative conditions repeated detection, condition slightly has difference, but detects every time
Contain blank control group (containing 1ng/ml TGF-βs 1), therefore be standardized with the group, i.e., by blank control group
Absorbance values are all standardized as 1.Ang II, SP, A799, S-17902 and bradykinin play the role of to promote cell propagation;Its
In, Ang II promote the best results (p of NIH3T3 propagation<0.05), SP, A799, S-17902 and bradykinin compare no system two-by-two
Meter learns meaning (p>0.05).Losartan, L-733060, Ang 1-7, AcSDKP, 2 kinds of brad ykinin antagonists (DALBK and HOE-
140) and Lisinopril can suppress cell propagation, wherein Losartan, L-733060 and Lisinopril inhibition compared with
Ang 1-7, AcSDKP and 2 kinds of brad ykinin antagonists more preferably (p<0.01), but the difference between former three between rear four
Not statistically significant (p>0.05).
Collagen generation situation is shown in Fig. 9.Ang II, SP, A799, S-17902 and bradykinin can promote collagen to generate;Its
In, Ang II promote the collagenogenic best results (p of NIH3T3<0.05), SP, A799, S-17902 and bradykinin compare two-by-two
Not statistically significant (p>0.05).Losartan, L-733060, Ang 1-7, AcSDKP, 2 kinds of brad ykinin antagonists and
Lisinopril can suppress collagen generation, and wherein Losartan, L-733060 and Lisinopril inhibition are compared with Ang 1-
7th, AcSDKP and 2 kinds of brad ykinin antagonists more preferably (p<0.01), but the difference between former three between rear four is without system
Meter learns meaning (p>0.05).
3. experiment conclusion:
This experimental study ACE classes medicine promotion to cicatrization or inhibitory action in vitro.Wherein, Losartan,
L-733060, Ang 1-7, AcSDKP, 2 kinds of brad ykinin antagonists (DALBK and HOE-140) and Lisinopril can suppress into fibre
Cytoactive is tieed up, Losartan, L-733060 and Lisinopril inhibition are compared with Ang 1-7, AcSDKP and 2 kinds of bradykinins
Antagonist is more preferably.
Claims (9)
1. a kind of anti-cicatrix externally used preparation of compound Angiotensin-Converting class, it is characterised in that tight by one or more blood vessels
Element conversion enzyme drug and other one or more anti-scarring drug active ingredients form, and the quality of active ingredient is dense in preparation
Spend for 0.05%-25%.
A kind of 2. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
The Angiotensin-Converting class choice of drug ARB, N- acetyl group-seryl-aspartoyls-
Lysyl-proline, hypertensin 1-7, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 antagonist, brad ykinin antagonists and Angiotensin-Converting suppress
Agent;Wherein, ARB is selected from Losartan, Irbesartan, Valsartan, Telmisartan, Olmesartan, candy
Sha Tan;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 antagonist is selected from L-733060;Brad ykinin antagonists are selected from DALBK and HOE-140;Angiotensin-Converting
Inhibitor is selected from lisinopril, Ramipril, captopril, Cilazapril, enalapril, benazepil.
A kind of 3. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
Other described anti-scarring drugs are from Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid.
A kind of 4. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
A variety of Angiotensin-Converting class effective ingredient combinations are:(1) ARB combines with ACEI, quality proportioning 0.33-
3:0.33-3;(2) ARB and SP antagonist-combination, quality proportioning 0.33-3:0.33-3;(3) ACEI and SP antagonist,
The antagonist-combination of bradykinin, quality proportioning 0.33-3:0.33-3:0.33-3;(4) ARB combines SP antagonist, bradykinin
Antagonist-combination, quality proportioning 0.33-3:0.33-3:0.33-3;(5) ARB combines SP antagonist, the antagonism of bradykinin
Agent, and N- acetyl group-seryl-aspartoyl-lysyl-proline, hypertensin 1-7 combine, and quality proportioning is
0.33-3:0.33-3:0.33-3:0.33-3:0.33-3。
A kind of 5. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
Various other anti-scarring drug combination of active principles modes are:(1) Triamcinolone acetonide is combined with heparin, Bulbus Allii Cepae extract, and quality is matched somebody with somebody
Than for 0.33-3:0.33-3:0.33-3;(2) Triamcinolone acetonide combines with asiaticosid, quality proportioning 0.33-3:0.33-3;
(3) Bulbus Allii Cepae extract, heparin combine with asiaticosid, quality proportioning 0.33-3:0.33-3:0.33-3;(4) Triamcinolone acetonide with
Bulbus Allii Cepae extract, heparin and asiaticosid combination, quality proportioning 0.33-3:0.33-3:0.33-3:0.33-3;(5) heparin with
Bulbus Allii Cepae extract combines, quality proportioning 0.33-3:0.33-3.
A kind of 6. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
When being combined by multi-medicament active principle, the matter such as it is transferred on the mass mixings such as each group is divided into, or the quality of any of which component
3 times of highest during amount or minimum 1/3 times when the quality such as being adjusted downward to.
A kind of 7. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
The formulation of described preparation be solution, pulvis, lotion, liniment, finish, emulsion containing creme, ointment containing emulsifiable paste, paste, plaster,
Gel, plastics, aerosol or spray, emplastrum, other formulations etc..
A kind of 8. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 7, it is characterised in that
Solution is tincture and spirit, and emplastrum is rubber ointment, Babu plaster, bar cloth patch, and other are to be dissolved in dimethyl sulfoxide (DMSO)
Formulation.
A kind of 9. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that
The preparation needs aseptic process.
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