CN107638522B - Traditional Chinese medicine composition for mainly treating wind-cold type common cold and relieving exterior syndrome and clearing heat as well as preparation process and application thereof - Google Patents
Traditional Chinese medicine composition for mainly treating wind-cold type common cold and relieving exterior syndrome and clearing heat as well as preparation process and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine preparation, and relates to a traditional Chinese medicine composition for mainly treating wind-cold type common cold and relieving exterior syndrome and clearing heat, and a preparation process and application thereof. The traditional Chinese medicine composition comprises, by mass, 200 parts of schizonepeta spike, 60 parts of mint, 100 parts of divaricate saposhnikovia root, 100 parts of radix bupleuri, 60 parts of perilla leaf, 100 parts of kudzuvine root, 60 parts of platycodon root, 80 parts of bitter almond, 60 parts of angelica dahurica, 200 parts of bunge corydalis herb, 160 parts of reed rhizome and 180 parts of medicated leaven; the medicated leaven is prepared from medicated leaven polysaccharide, and the rest herbs are extracted from the medicated leaven polysaccharide. Compared with the prior art, the traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat disclosed by the invention is added with the medicated leaven polysaccharide, and the medicated leaven polysaccharide contains more carboxyl groups and can be complexed with metal ions to inhibit the catalytic oxidation effect of the medicated leaven polysaccharide; meanwhile, the tianmu dizzy is introduced into the auxiliary materials of the syrup, which inhibits the growth of microorganism and plays a role of preservative.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and relates to a traditional Chinese medicine composition for mainly treating wind-cold type common cold and relieving exterior syndrome and clearing heat, and a preparation process and application thereof.
Background
Wind-cold type common cold is caused by the invasion of pathogenic wind-cold and the failure of lung-qi to disperse. Symptoms are visible: severe aversion to cold, mild fever, no sweat, headache, body pain, nasal obstruction, clear nasal discharge, cough, thin and white sputum, thirst, hot drink preference, and thin and white tongue coating. At present, a plurality of medicines for treating the wind-cold type common cold exist. Western medicine and Chinese medicine may be used, and dietotherapy may be adopted. The preventive measures are to pay attention to warm keeping, strengthen physical exercise and improve immunity. The therapeutic method of traditional Chinese medicine is mainly to relieve exterior syndrome with pungent and warm natured drugs. The Chinese patent medicine has the characteristics of small side effect and good curative effect, so the Chinese patent medicine is more and more favored by people.
The granule for clearing heat for treating common cold is prepared from 11 Chinese medicinal materials including herba Schizonepetae, herba Menthae, radix Saposhnikoviae, bupleuri radix, folium Perillae, and radix Puerariae, has effects of dispelling pathogenic wind and cold, relieving exterior syndrome and clearing heat, and can be used for treating wind-cold type common cold, headache, fever, aversion to cold, body pain, watery nasal discharge, cough and dry throat. The Chinese pharmacopoeia 2015 year edition records. The preparation method of the cold clearing heat granule comprises the following steps: extracting volatile oil from herba Schizonepetae, herba Menthae and folium Perillae, and collecting distilled water solution; decocting the residue and the rest eight materials with water twice, mixing decoctions, filtering, and mixing the filtrate with the above water solution; concentrating the mixed solution to obtain fluid extract with relative density of 1.32-1.35(50 deg.C), adding appropriate amount of sucrose, dextrin and ethanol, granulating, drying, adding above volatile oil, and mixing.
The cold and heat clearing granules have better adverse effect on the market, but have some problems. Because the cold clearing heat granule contains more traditional Chinese medicines and has complex components, the cold clearing heat granule is not particularly stable by adding some effective components such as puerarin and the like. In addition, because the volatile oil is directly sprayed on the granules in the actual production process, the taste of the medicine is poor, and the patient is difficult to swallow. Therefore, the research on taste modification and stability of the granules for clearing heat from cold is always the focus of pharmaceutical research. On the basis of the original formula, the cold clearing heat granule and the preparation thereof are improved, and have positive significance.
Disclosure of Invention
Aiming at the problems, through experiments and researches, the invention provides a traditional Chinese medicine composition for relieving exterior syndrome and clearing heat, which is beneficial to treating wind-cold type common cold and has stable components, and a preparation process and application thereof.
The traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat comprises, by mass, 200 parts of schizonepeta spike, 60 parts of mint, 100 parts of divaricate saposhnikovia root, 100 parts of radix bupleuri, 60 parts of perilla leaf, 100 parts of kudzu root, 60 parts of platycodon grandiflorum, 80 parts of bitter almond, 60 parts of angelica dahurica, 200 parts of corydalis bungeana, 160 parts of rhizoma phragmitis and 180 parts of medicated leaven; massa Medicata Fermentata polysaccharide and extract thereof for the rest materials; the preparation method of the medicated leaven polysaccharide comprises the following steps: pulverizing Massa Medicata Fermentata into 60-80 mesh, decocting with 8 times of water for 1 hr, extracting for 2 times, filtering to obtain filter residue, and adding 1% Na into the filter residue2 CO3Stirring for 2h at 50 ℃, centrifuging, regulating the pH of supernatant to 2 by using hydrochloric acid, standing, filtering to obtain filter residue, washing by using ethanol, and drying under reduced pressure to obtain a crude product, dissolving by using 5 times of water, performing DEAE cellulose anion column chromatography, eluting by using 0.05mol/L NaCl for 5 times of volume, discarding, eluting by using 0.1mol/L NaCl, collecting the 7-10 times of volume, drying under reduced pressure, dissolving by using 6-10 times of water, cooling, precipitating, and separating precipitate to obtain the compound.
The preparation process of the traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat provided by the invention comprises the following steps: 1) extracting herba Schizonepetae, herba Menthae and folium Perillae with 8 times of water to obtain volatile oil, and distilling to obtain volatile oil water solutionCollecting the residues for later use; 2) pulverizing Massa Medicata Fermentata into 60-80 mesh, decocting with 8 times of water for 1 hr, extracting for 2 times, filtering to obtain filter residue, and adding 1% Na into the filter residue2 CO3Stirring for 2h at 50 ℃, centrifuging, regulating the pH of supernatant to 2 by using hydrochloric acid, standing, filtering to obtain filter residue, washing by using ethanol, and drying under reduced pressure to obtain a crude product, dissolving by using 5 times of water, performing DEAE cellulose anion column chromatography, eluting by using 0.05mol/L NaCl for 5 times of volume, discarding, eluting by using 0.1mol/L NaCl, collecting the 7-10 times of volume, drying under reduced pressure, dissolving by using 6-10 times of water, cooling, precipitating, and separating and precipitating to obtain the medicated leaven polysaccharide for later use; 3) decocting the residue and the rest materials with 8 times of water twice, mixing decoctions, filtering, and mixing the filtrate with the volatile oil water solution to obtain mixed solution; 4) concentrating the combined solution into clear paste with the relative density of 1.32-1.35 at 50 ℃, adding the medicated leaven polysaccharide and uniformly stirring.
The invention relates to syrup of a traditional Chinese medicine composition for treating wind-cold type common cold, which has the functions of relieving exterior syndrome and clearing heat, and the preparation process comprises the following steps: boiling sucrose in water, filtering, mixing with the Chinese medicinal composition, adding antiseptic, adding water to desired amount, mixing, and packaging.
The syrup of the traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat is prepared from one of sorbic acid, tianmu dihuang and benzoic acid as an antiseptic.
The syrup of the traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat provided by the invention has the weight volume ratio of sucrose in the preparation being more than 45%.
The syrup of the traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat, disclosed by the invention, has the preservative with the percentage content of less than 0.3 percent in the preparation.
The application of the traditional Chinese medicine composition is used for preparing a medicine for treating wind-cold type common cold.
Compared with the prior art, the traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat disclosed by the invention is added with the medicated leaven polysaccharide, and the medicated leaven polysaccharide contains more carboxyl groups and can be complexed with metal ions to inhibit the catalytic oxidation effect of the medicated leaven polysaccharide; meanwhile, the tianmu dizzy is introduced into the auxiliary materials of the syrup, which inhibits the growth of microorganism and plays a role of preservative.
Detailed Description
The exterior syndrome relieving and heat clearing Chinese medicinal composition for mainly treating wind-cold type common cold, the preparation process and the application thereof are further described in the following with reference to specific examples, but the scope of protection of the invention is not limited thereto.
Example 1
Syrup raw material prescription: 200g of schizonepeta spike, 60g of mint, 100g of divaricate saposhnikovia root, 100g of Chinese thorowax root, 60g of perilla leaf, 100g of kudzuvine root, 60g of platycodon root, 80g of bitter apricot seed, 60g of dahurian angelica root, 200g of bunge corydalis herb, 160g of reed rhizome, 180g of medicated leaven, 200g of cane sugar and 1g of sorbic acid.
The preparation process of the traditional Chinese medicine composition comprises the following steps: 1) adding 8 times of water into herba Schizonepetae, herba Menthae and folium Perillae, extracting volatile oil, collecting volatile oil water solution, and collecting residue; 2) pulverizing Massa Medicata Fermentata into 60-80 mesh, decocting with 8 times of water for 1 hr, extracting for 2 times, filtering to obtain filter residue, and adding 1% Na into the filter residue2 CO3Stirring for 2h at 50 ℃, centrifuging, regulating the pH of supernatant to 2 by using hydrochloric acid, standing, filtering to obtain filter residue, washing by using ethanol, and drying under reduced pressure to obtain a crude product, dissolving by using 5 times of water, performing DEAE cellulose anion column chromatography, eluting by using 0.05mol/L NaCl for 5 times of volume, discarding, eluting by using 0.1mol/L NaCl, collecting the 7-10 times of volume, drying under reduced pressure, dissolving by using 6-10 times of water, cooling, precipitating, and separating and precipitating to obtain the medicated leaven polysaccharide for later use; 3) decocting the residue and the rest materials with 8 times of water twice, mixing decoctions, filtering, and mixing the filtrate with the volatile oil water solution to obtain mixed solution; 4) concentrating the combined solution into clear paste with the relative density of 1.32-1.35 at 50 ℃, adding the medicated leaven polysaccharide and uniformly stirring.
The preparation process of the syrup comprises the following steps: boiling sucrose 250g in water, filtering, mixing with the Chinese medicinal composition, adding sorbic acid 1g, adding water to 500ml, mixing, and packaging into two bottles.
Example 2
Syrup raw material prescription: 200g of schizonepeta spike, 60g of mint, 100g of divaricate saposhnikovia root, 100g of Chinese thorowax root, 60g of perilla leaf, 100g of kudzuvine root, 60g of platycodon root, 80g of bitter apricot seed, 60g of dahurian angelica root, 200g of bunge corydalis herb, 160g of reed rhizome, 180g of medicated leaven, 200g of cane sugar and 1g of tianmu lutein.
The preparation process of the traditional Chinese medicine composition comprises the following steps: 1) adding 8 times of water into herba Schizonepetae, herba Menthae and folium Perillae, extracting volatile oil, collecting volatile oil water solution, and collecting residue; 2) pulverizing Massa Medicata Fermentata into 60-80 mesh, decocting with 8 times of water for 1 hr, extracting for 2 times, filtering to obtain filter residue, and adding 1% Na into the filter residue2 CO3Stirring for 2h at 50 ℃, centrifuging, regulating the pH of supernatant to 2 by using hydrochloric acid, standing, filtering to obtain filter residue, washing by using ethanol, and drying under reduced pressure to obtain a crude product, dissolving by using 5 times of water, performing DEAE cellulose anion column chromatography, eluting by using 0.05mol/L NaCl for 5 times of volume, discarding, eluting by using 0.1mol/L NaCl, collecting the 7-10 times of volume, drying under reduced pressure, dissolving by using 6-10 times of water, cooling, precipitating, and separating and precipitating to obtain the medicated leaven polysaccharide for later use; 3) decocting the residue and the rest materials with 8 times of water twice, mixing decoctions, filtering, and mixing the filtrate with the volatile oil water solution to obtain mixed solution; 4) concentrating the combined solution into clear paste with the relative density of 1.32-1.35 at 50 ℃, adding the medicated leaven polysaccharide and uniformly stirring.
The preparation process of the syrup comprises the following steps: boiling sucrose 200g in water, filtering, mixing with the Chinese medicinal composition, adding 1g of tianmu dizein, adding water to 500ml, mixing, and packaging into two bottles.
Control group 1
Syrup raw material prescription: 200g of schizonepeta spike, 60g of mint, 100g of divaricate saposhnikovia root, 100g of Chinese thorowax root, 60g of perilla leaf, 100g of kudzuvine root, 60g of platycodon root, 80g of bitter apricot seed, 60g of dahurian angelica root, 200g of bunge corydalis herb, 160g of reed rhizome, 300g of cane sugar and 1g of sorbic acid.
The preparation process of the traditional Chinese medicine composition comprises the following steps: 1) adding 8 times of water into herba Schizonepetae, herba Menthae and folium Perillae, extracting volatile oil, collecting volatile oil water solution, and collecting residue; 3) decocting the residue and the rest materials with 8 times of water twice, mixing decoctions, filtering, and mixing the filtrate with the volatile oil water solution to obtain mixed solution; 4) the combined solution is concentrated into clear paste with the relative density of 1.32-1.35 at 50 ℃.
The preparation process of the syrup comprises the following steps: boiling sucrose 300g in water, filtering, mixing with the Chinese medicinal composition, adding sorbic acid 1g, adding water to 500ml, mixing, and packaging into two bottles.
Structural analysis of medicated leaven polysaccharide
In borax-sodium hydroxide buffer solution (pH 10), when the electric current is applied to the cellulose acetate membrane, the medicated leaven polysaccharide moves from negative electrode to positive electrode, and toluidine blue solution dyes, and the electrophoresis chart shows a single color band. Performing Sephadex G-100 column chromatography, wherein the elution curve is also single peak, drawing a standard curve by taking dextran with different molecular weights as reference, and calculating the molecular weight of 11200-11800u according to the volume of water in the column and the volume of water outside the column. Taking medicated leaven polysaccharide to perform acid hydrolysis, identifying three monosaccharides by TLC through hydrogen spectrum and reference substance control as D-glucose, L-rhamnose and D-glucuronic acid, and determining the molar ratio of the three components by gas chromatography after derivatization to be about 9:1: 3. All the OH at the 3-position of the D-glucose is not methylated and the 6-position of the D-glucose is not methylated by methylation analysis, which shows that the D-glucose exists in the main chain by 1 → 3 connection and has a branch chain connected at the 6-position; l-rhamnose and D-glucuronic acid are completely methylated, and are shown to be directly connected to the 6-position of D-glucose in a monosaccharide form. Through a high-resolution hydrogen spectrum, the chemical movement of hydrogen atoms of the carbon atoms at the sugar terminal groups is more than 5ppm except rhamnose, which indicates that the connections between D-glucose and D-glucuronic acid are both beta configuration, and the connections between D-glucose and L-rhamnose are alpha configuration. The order of linkage and repeat units of the individual monosaccharides is under further investigation. Measured with a capillary viscometer: the intrinsic viscosity of the medicated leaven polysaccharide with the concentration of 1mg/L at 30 ℃ is 70.8 cp.
Pharmacological research of medicated leaven polysaccharide
1. Effect on mouse subacute aging model: weighing 70 mice, randomly dividing into 7 groups, each group comprises 10 mice, each half of the mice is divided into a normal control group, a model control group, a positive control group, a medicated leaven polysaccharide group (high, medium and low dosage) and a medicated leaven group. Except for a normal control group, other mice are injected with 0.5 mL/mouse of 5 percent D-galactose every day subcutaneously for 6 weeks continuously to form a subacute aging model of the mice, and the gavage administration is started simultaneously with the model building, the medicated leaven polysaccharide group is drenched with corresponding drugs, the drug concentrations are 12mg/mL, 6mg/mL and 3mg/mL respectively, the administration volumes are 0.1mL/10g respectively, the medicated leaven group is drenched with corresponding drugs, the drug concentration is 0.45g/mL, the administration volumes are 0.3mL/10g respectively, the vitamin E200 mg/kg is administrated by the gavage of the positive control group, and the distilled water with equal volume is drenched into the stomach of the normal control group and the model group for 6 weeks continuously. 24 hours after the last gastric lavage administration, blood is collected and serum is separated, and SOD activity and MDA level in the mouse serum are measured. The results are shown in Table 1.
TABLE 1 influence of the levels of SOD and MDA in serum of D-galactose-induced subacute aging mice (` x. + -. s)
| Group of | N | SOD（U/ml） | MDA（nmol/ml） |
| Normal control group | 10 | 463.97±8.42 | 5.81±0.33 |
| Model control group | 9 | 352.2±6.12** | 9.67±0.49** |
| Positive control group | 10 | 461.36±4.14## | 6.11±0.35## |
| High dose group | 10 | 462.09±9.13 | 5.97±0.43 |
| Middle dose group | 9 | 459.19±7.97# | 6.31±0.49# |
| Low dose group | 10 | 417.56±6.87## | 7.56±0.70## |
| Medicated leaven group | 10 | 373.79±4.71## | 9.11±0.38## |
Comparing to normal group;#: comparing to a model set; or#：P<0.05;**or##：P<0.01.
Stability test
The syrups prepared in examples 1-2 and control 1 were placed at 40 ℃. + -. 2 ℃ and 75%. + -. 5% humidity for 6 months, and sampled at 1, 3 and 6 months, respectively, to determine the content.
The content determination method comprises the following steps: the measurement is carried out by high performance liquid chromatography (0512 in the four-department general regulation of the 2015 edition in China pharmacopoeia).
Octadecylsilane chemically bonded silica is used as a filler in chromatographic conditions and system applicability tests; acetonitrile-water (11: 89) is used as a mobile phase; the detection wavelength was 250 nm. The number of theoretical plates should not be lower than 4500 calculated according to puerarin peak.
Preparation of reference solution A proper amount of puerarin reference is precisely weighed, and 30% ethanol is added to prepare a solution containing 16 μ g of puerarin per 1 ml.
Preparing a sample solution, precisely weighing about 20g of the sample solution, placing the sample solution into a conical flask with a plug, precisely adding 50ml of 30% ethanol, sealing the plug, weighing, carrying out ultrasonic treatment (power of 250W and frequency of 33 kHz) for 20 minutes, cooling, weighing again, supplementing the lost weight with 30% ethanol, shaking up, filtering, and taking a subsequent filtrate to obtain the final product.
The determination method comprises precisely sucking 10 μ l of each of the reference solution and the sample solution, injecting into liquid chromatograph, and determining. Calculating the content (mg) of puerarin C21H20O9 in each bottle (the content is 250 g). The results are shown in Table 2.
TABLE 2 content of puerarin in syrups obtained in examples 1-2 and control 1
The stability test result shows that: the syrup prepared in the example 1-2 is placed under the conditions of 40 ℃ +/-2 ℃ and 75% +/-5% humidity for 6 months, the content of puerarin is basically not changed, while the content of puerarin in the syrup prepared in the control group 1 is obviously reduced, which indicates that the active ingredients of the syrup can be basically stabilized by the stabilizing agent of the medicated leaven polysaccharide in the prescription of the example 1-2.
Microbial Limit test
According to the microbial limit examination of non-sterile products (general rules of the four departments of the 'Chinese pharmacopoeia' 2015 edition): microorganism count method (general rule 1105), control bacteria inspection method (general rule 1106) and non-sterile drug microorganism limit standard (general rule 1107). The method comprises the following steps: the total number of aerobic bacteria should not exceed 104cfu/g; the total number of the mould and the yeast should be not more than 102cfu/g; escherichia coli could not be detected (l g); salmonella (10 g) could not be detected; the number of the bile salt resistant gram-negative bacteria should be not more than 102cfu (1 g). The results are shown in Table 3.
TABLE 3 results of microbial limit measurement of examples 1-2 and control 1
| Group of | Total aerobic count (cfu/g) | Total number of mold and Yeast (cfu/g) | Escherichia coli and Salmonella (per/g) | Gram-negative bacteria resistant to bile salt (one/g) |
| Example 1 | 537 | 49 | 0 | 17 |
| Example 2 | 341 | 21 | 0 | 8 |
| Control group 1 | 561 | 64 | 0 | 23 |
Comparison of mouthfeel
The same amount of each of the syrups prepared in examples 1 and 2 and the commercially available granules for clearing away cold heat were sampled by 10 subjects. The results show that: the syrups of examples 1-2 were slightly sweet and non-bitter. However, after being dissolved in water and taken orally, the commercial cold-clearing granules are slightly sweet, and then have a bitter taste in the mouth.
Claims (7)
1. The traditional Chinese medicine composition for treating wind-cold type common cold and relieving exterior syndrome and clearing heat is characterized by being prepared from the following raw materials in parts by mass: 200 parts of schizonepeta spike, 60 parts of mint, 100 parts of divaricate saposhnikovia root, 100 parts of Chinese thorowax root, 60 parts of perilla leaf, 100 parts of kudzuvine root, 60 parts of platycodon root, 80 parts of bitter apricot seed, 60 parts of dahurian angelica root, 200 parts of bunge corydalis herb, 160 parts of reed rhizome and 180 parts of medicated leaven; massa Medicata Fermentata polysaccharide and extract thereof for the rest materials; the preparation method of the medicated leaven polysaccharide comprises the following steps: pulverizing Massa Medicata Fermentata into 60-80 mesh, decocting with 8 times of water for 1 hr, extracting for 2 times, filtering to obtain filter residue, and adding 1% Na into the filter residue2 CO3Stirring for 2h at 50 ℃, centrifuging, regulating the pH of supernatant to 2 by using hydrochloric acid, standing, filtering to obtain filter residue, washing by using ethanol, and drying under reduced pressure to obtain a crude product, dissolving by using 5 times of water, performing DEAE cellulose anion column chromatography, eluting by using 0.05mol/L NaCl for 5 times of volume, discarding, eluting by using 0.1mol/L NaCl, collecting the 7-10 times of volume, drying under reduced pressure, dissolving by using 6-10 times of water, cooling, precipitating, and separating precipitate to obtain the compound.
2. The preparation process of the traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following steps: 1) adding 8 times of water into herba Schizonepetae, herba Menthae and folium Perillae, extracting volatile oil, collecting volatile oil water solution, and collecting residue; 2) pulverizing Massa Medicata Fermentata into 60-80 mesh powder, and sieving with 8 mesh sieveDecocting in water for 1 hr, extracting for 2 times, filtering to obtain residue, and adding 1% Na2 CO3Stirring for 2h at 50 ℃, centrifuging, regulating the pH of supernatant to 2 by using hydrochloric acid, standing, filtering to obtain filter residue, washing by using ethanol, and drying under reduced pressure to obtain a crude product, dissolving by using 5 times of water, performing DEAE cellulose anion column chromatography, eluting by using 0.05mol/L NaCl for 5 times of volume, discarding, eluting by using 0.1mol/L NaCl, collecting the 7-10 times of volume, drying under reduced pressure, dissolving by using 6-10 times of water, cooling, precipitating, and separating and precipitating to obtain the medicated leaven polysaccharide for later use; 3) decocting the residue and the rest materials with 8 times of water twice, mixing decoctions, filtering, and mixing the filtrate with the volatile oil water solution to obtain mixed solution; 4) concentrating the combined solution into clear paste with the relative density of 1.32-1.35 at 50 ℃, adding the medicated leaven polysaccharide and uniformly stirring.
3. The syrup prepared from the traditional Chinese medicine composition according to claim 1, wherein the preparation process comprises the following steps: boiling sucrose in water, filtering, mixing with the Chinese medicinal composition, adding antiseptic, adding water to desired amount, mixing, and packaging.
4. A syrup made of the Chinese medicinal composition according to claim 3, wherein the preservative is one of sorbic acid, tiangmuixanthin and benzoic acid.
5. A syrup made of the traditional Chinese medicine composition according to claim 3, wherein the weight volume ratio of the sucrose in the preparation is more than 45%.
6. The syrup of claim 4, wherein the preservative is present in an amount of less than 0.3% of the formulation.
7. The application of the traditional Chinese medicine composition according to claim 1, which is used for preparing a medicine for treating wind-cold type common cold.
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