CN107638422A - Hydrochloric acid terbinafine is used for the method and composition of long-acting treatment dermatophytid infection - Google Patents

Abstract

The invention discloses the method and composition that a kind of hydrochloric acid terbinafine is used for long-acting treatment dermatophytid infection, belong to pharmaceutical preparations technology field.Quality percent by volume of the component and each component of the composition in whole solution is as follows：Pharmacological active substance：0.1~20%, filmogen：0.1~15%, drug release material：0~15%, rate accelerating material：0.1~15%, other nonessential excipient 0~10%, surplus is mixed solvent.Methods described is related to a kind of skin-use preparation with new medicinal products dermal delivery and mechanism of action, it is characterized in that initiative using skin as drug-reservoir, using the dynamic process of skin metabolism, from inside to outside, medicine is pushed to skin superficial layer, realizes the effect of long-acting treatment；Meanwhile one layer of true film is formed in affected area after preparation administration, prevent focus to be infected again, realize the dual bacteriostatic effect of physical isolation and Drug inhibition.

Description

Hydrochloric acid terbinafine is used for the method and composition of long-acting treatment dermatophytid infection

Technical field

The invention belongs to pharmaceutical preparations technology field, be related to it is a kind of can long-acting treatment dermatophytid infection external preparation and Its preparation method, more particularly to a kind of hydrochloric acid terbinafine are used for the method and composition of long-acting treatment dermatophytid infection.

Background technology

At present, a large amount of uses of extensive pedigree antibiotic, immunodepressant, immune deficiency, organ transplant and various Interventionals The increase of medical procedure, various fungal infections are formed causes the incidence of disease of fungal infection to increase year by year than constantly change etc. so that The antifungal drug and its preparation of various highly effective and safes turn into the new focus of domestic and international field of medicaments research and development.

Hydrochloric acid terbinafine is Allylamines broad spectrum high-effect antifungal, to pathogenic deep fungal and superficial layer fungi It is respectively provided with inhibitory action.At present, it is main to penetrate into, accumulate in cuticula after hydrochloric acid terbinafine dermal topical application, in focus portion Position plays local bacteriostatic effect, therefore clinically hydrochloric acid terbinafine local application is mainly used in superficial layer fungal infection, it is difficult to Suppress intrusion to cuticula deep, the hypha,hyphae and gemma of skin corium.In order to improve controlling for skin deep part fungal infection Therapeutic effect, the oral formulations of hydrochloric acid terbinafine are clinically released, but medicine is delivered to the drug concentration up to skin by oral administration 1/10~1/2 be only locally administered, and the dose of epidermis, skin corium be only cuticula 1/25-1/12 (Balfour J A, Faulds D .Terbinafine.A review of its pharmacodynamic and pharmacokinetic Properties, and therapeutic potential in superficial mycoses. [J] Drugs, 1992,43 (2)：259-284.), at the same can bring many adverse reaction.Thus, hydrochloric acid terbinafine is delivered to using preparation means Deep skin, improve it and suppress the therapeutic effect of deeper part fungal infection, reduce adverse reaction, there is very important clinical meaning Justice.

Skin is the target site for treating dermatophytid infection.Dermal delivery pharmacological active substance can both improve true to skin The targeting of bacterium infection, therapeutic effect is improved, and can avoids medicine from entering body circulation, reduces injury of the medicine to body, subtracts Few adverse reaction.Thus, dermal delivery physiological activator treats the great clinical value of dermatophytid infection.Face at present The hydrochloric acid terbinafine formulation commonly used on bed has cream, such as Hydrochloric acid terbinafine emulsifiable paste,Hydrochloric acid terbinafine Cream, 999Hydrochloric acid terbinafine emulsifiable paste etc.；Spray, such as Hydrochloric acid terbinafine spray,Salt The liquid such as sour terbinafine spray etc., these preparations are easily wiped after applying by clothing, sweat washes out, while can pollute clothing Thing, needs repetitively administered after, and Clinical practice is extremely inconvenient；Meanwhile fungal infection has the characteristics of infection rate is high again, is Ensure good therapeutic effect, realize the long-term effect of preparation, prevent focus from infecting again to be necessary.Thus, a kind of tool Have it is long-acting, prevent from focus from infecting again and hydrochloric acid terbinafine percutaneous dosing can be improved controlling deep, superficial layer fungal infection Therapeutic effect, it is great exploitation and application prospect.

The content of the invention

Goal of the invention is in order to solve problems of the prior art, and it is an object of the invention to provide a kind of hydrochloric acid spy ratio Naphthols is used for the method and composition of long-acting treatment dermatophytid infection.

An object of the present invention is to provide a kind of method that hydrochloric acid terbinafine is used for long-acting treatment dermatophyte sense, should Method, which is related to one kind, has new medicinal products dermal delivery and mechanism of action, initiative using skin as drug-reservoir, utilizes The dynamic process of skin metabolism, from inside to outside, medicine is pushed to skin superficial layer, ensures that affected area has effective dose Medicine, realize long-acting bacteriostatic act on；At the same time, after preparation is applied, one layer of true film can be formed on focus surface, prevents disease Stove is fungi-infected again, realizes physical isolation and the effect of Drug inhibition dual bacteriostatic.

It is a further object of the present invention to provide the combination that a kind of hydrochloric acid terbinafine is used for long-acting treatment dermatophytid infection Thing, said preparation can improve the therapeutic effect of fungal infection, and further realize that long-acting treatment acts on, and Clinical practice is convenient, energy Enough improve the compliance of patient.

Technical scheme is to realize the purpose of foregoing invention, and the technical scheme taken is as follows：

Percutaneous dosing refers to there is pharmacological activity effect on the skin of individual, in skin or by the dermal administration of individual Medicine, realize to local lesion, Lesional Skin different depth delivering medicine, play therapeutic action.The present invention provides a kind of use In the new medicinal products dermal delivery and mechanism of action of long-acting treatment dermatophytid infection.

New medicinal products delivering and mechanism of action are that it is initiative using skin as drug-reservoir, utilize skin The dynamic process of metabolism, from inside to outside, medicine is pushed to skin superficial layer, ensures that affected area has effective dose of medicine Thing, realize that long-acting treatment acts on.It is being administered in 0~6 hour initial stage, the effect by medicine by preparation, is being delivered to skin keratin Layer depth layer and skin corium superficial layer position, drug-reservoir is used as using skin.In the dynamic process of skin metabolism, medicine by It is interior and outer, pushed to the superficial layer of keratoderma, suppress from deep skin to superficial layer and kill fungi.Skin metabolism Cycle length, medicine can be resident for a long time inside skin and the medicine of resident effective dose, so as to realize long-acting treatment skin The effect of fungal infection, while improve the therapeutic effect of Stratum Corneum deep and skin corium superficial layer fungal infection.

Present invention particularly provides a kind of hydrochloric acid terbinafine be used for long-acting treatment dermatophytid infection method with combining Thing, the quality percent by volume of its base stock and each component in whole solution are as follows：

(a) pharmacological active substance：0.1~20%, the pharmacological active substance is antimycotic medicine, preferable antimycotic Class medicine be terbinafine, Butenafine, Naftifine, clotrimazole, econazole, Isoconazole, bifonazole, ketoconazole, Miconazole, Oxiconazole, Sertaconazole, terconazole, tioconazole, sulconazole, Amorolfine, Tolnaftate, undecenoic acid, Ciclopirox, further Preferably hydrochloric acid terbinafine, its preferred content are 0.1~10%.

(b) filmogen：0.1~15%, the filmogen is preferably one or more mixing of cellulose derivative, Preferably ethyl cellulose, viscosity are combinations one or more in 7cp-100cp.

(c) drug release material：0~15%, the drug release material is in gel matrix material, drug carrier material One or more combinations.

(d) rate accelerating material：0.1~15%, the plasticizer is preferably glycerine, polyethylene glycol, triethyl citrate, citric acid Tributyl, triacetyl glycerine, fractionated coconut oil, diethyl phthalate, dibutyl phthalate, the fourth of SA two One or more combination in ester, ATEC, tributyl 2-acetylcitrate, wherein the polyethylene glycol is relative Molecular weight is 200~6000.

(e) other nonessential excipient 0~10%, the classification of the nonessential excipient include be not limited to it is following it One or combination：Penetration enhancer, chelating agent, isotonic regulator, bacteriostatic agent, flavouring, antioxidant, ultra-violet absorber, purple Outside line screener and physics hide flaw material.

(f) mixed solvent, the mixed solvent are preferably that mixing one or more in purified water, ethanol, isopropanol is molten Agent, the mixed solvent total content of one or more of which include respectively 10~99.4% (w/v) of total composition ethanol, different The purified water of propyl alcohol or its composition and 0~90% (w/v).

One of main material of the present invention is the ethyl cellulose with filming performance.Ethyl cellulose (ethylcellulose) be ethyoxyl displacement hydroxyl cellulose derivative, be a kind of hydrophobic material, nontoxicity, non-stimulated Property, without sensitization, its film-forming temperature is low, film forming is preferable, has preferable tensile strength and elasticity, is a kind of wide variety of skin The framework material of skin controlled release film.Main material of the ethyl cellulose as long-acting spray-filming agent, it is characterised in that film-forming temperature It is low, can under skin surface temperature voluntarily film forming, film forming speed is fast, and film properties are good, and the film of formation has water resistance, to skin Skin has certain adhesion.

According to the difference of prescription, composition provided by the invention can be with different dosage form applications.In some implementations In example, can exist in liquid form, so that the spray of propellant need not be applied to use, or to need using propellant Aerosol is used, and preparation is sprayed on skin surface with vaporific, and one layer of true film is formed in skin surface.In certain embodiments, preparation Preparation can also be coated on by skin with the formulation application of liquid of vicidity, boehmite gel, gel, supensoid agent and other forms Surface, one layer of true film is formed in skin surface.

Composition provided by the invention, its film formed on skin is one layer of non-boundary, complete, fine and close, smooth true Film, there is waterproof, the performance of rub resistance, prevent that skin is fungi-infected again in a manner of physically-isolated.

Meanwhile in preparation process, medicine is sufficiently mixed uniformly with filmogen under the action of the solvent, text message, Some drugs are distributed between membrane material, when film shaping, drying are attached on skin, can be distributed on film, extraneous to skin The fungi of environment (such as foot's fungal infection, the presence of fungi also being had in shoes) has certain inhibitory action, so as to from another One mode prevents that skin is fungi-infected again.

Solvent in material of the present invention includes certain ethanol or isopropanol, on the one hand dissolves water-insoluble material as solvent Material, on the one hand as skin penetration enhancer.Meanwhile rate of drying of the preparation on skin can be accelerated (in some embodiments In can be understood as improve film formation time).

Contain ethanol or isopropanol in the preparation of the present invention as skin penetration enhancer, mainly after administration, system Agent film forming, drying stage on skin, ethanol or isopropanol promote the absorption of medicine.

For some embodiments, the amount of alcohol of single dose administration is not enough to deliver drugs into the target location of skin (especially spray-filming agent, it is sprayed in the form of vaporific, and ethanol largely volatilizees in atmosphere, causes amount of alcohol deficiency).Therefore, originally Invention adds other functional materials, such as skin absorption promoter in prescription, and joint promotes absorption of the medicine in skin.

Penetration enhancer is to ensure that physiological activator effectively penetrates into expected target site in known manner.As excellent Choosing, the penetration enhancer are azone class and the like, terpenes, fatty acid, nonionic emulsifier and more Nonionic in one or more combinations of first alcohols, preferably azone, oleyl alcohol, ethanol, isopropanol and water-based system Type emulsifying agent.

To promote medicine, in certain embodiments, present invention adds drug release material in the absorption of skin.

Preferable drug release material includes combination one or more in drug carrier material, gel matrix material.

The drug release material, the penetrating power of some medicines on the one hand as the carrier of medicine, can be improved；One side Face can pin a certain amount of alcoholic solution in the formulation, after preparation attaches to skin so that preparation is remained to by alcoholic solution Promote the effect of oozing, increase the depth of penetration of medicine.Understood in some embodiment comparison process, add gel matrix material and be not added with The preparation of gel matrix material, after film forming, drying, the preparation for adding gel matrix material still suffers from the smell of faint alcohol, And the preparation of gel matrix material is not added with, in the absence of the smell of alcohol.This explanation, the addition of other functional materials can be one Determine in degree " to pin " alcoholic solution (playing transdermal facilitation), depth of penetration of the medicine in skin is increased with this.

Hydrochloric acid terbinafine provided by the present invention is used for the method and composition of long-acting treatment dermatophytid infection, its In, hydrochloric acid terbinafine is a kind of broad-spectrum antifungal medicine, and effective Mlc is low.Its therapeutic effect is dense with the medicine in skin Positive correlation is spent into, so ensureing that skin drug concentration on effective Mlc, can reach therapeutic effect.Together When, hydrochloric acid terbinafine high concentration accumulates the report for also having no adverse reaction in skin.So for this patent, one Secondary property is delivered drugs into skin, and the dose delivered every time is low, will not produce side effect.

In the present invention, after medicine is delivered to skin inside, medicine is under the dynamic process of skin metabolism, by depth To shallow, skin surface is gradually pushed to, until excreting.Skin is the maximum organ of human body, also serves as living matter storage Storehouse maintains basic physiological function.The present invention, as drug-reservoir, skin depth is delivered drugs into administration initial stage by skin Portion (mainly epidermis deep), epidermis is arrived in the case where the dynamic of skin metabolism promotes, until excreting, herein dynamically Period, effective Mlc is maintain inside skin, realizes long-acting bacteriostasis.

The time that medicine excretes with the metabolism of skin, the depth being delivered to according to medicine in skin have Close, within the specific limits, the skin depth of delivering is deeper, and the time excreted through metabolism is longer.But work as and reach one Fixed scope, soon close to hypodermis when, be easily accessible blood circulation, be unfavorable for play local treatment effect.Pass through The ratio of each component is adjusted, adjusts the ability of the delivering medicine of preparation.

In certain embodiments, it with the addition of beneficial excipient in component, including it is chelating agent, isotonic regulator, antibacterial Agent, flavouring, antioxidant, ultra-violet absorber, ultraviolet light screener and physics hide flaw material.

Preferably, the antioxidant is sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, sodium thiosulfate, dimension life Plain C, amino acids, dithiothreitol dithio, thioglycerol, benzenediol, tocopherol, propylgallate, just double hydrogen guaiacol, One or more combinations in butylated hydroxyarisol, dibutyl cresols.

Preferably, the bacteriostatic agent is the one or more in methyl hydroxybenzoate, benzalkonium bromide, benzalkonium chloride, eugenol Combination.

Preferably, it is titanium dioxide, zinc oxide, kaolin, oxidation that the ultraviolet light screener and physics, which hide flaw material, One or more mixing in ferrous iron, calcium carbonate, talcum powder, for aiding in, preventing wound surface from being irradiated by ultraviolet, cover scar Trace.The components such as water-soluble or insoluble pigment (or pigment) can be optionally added, the film of the nearly colour of skin is formed, can also play physics Hide the effect of the flaw.

Brief description of the drawings

Fig. 1：It is commercially availableHydrochloric acid terbinafine emulsifiable paste,Hydrochloric acid terbinafine spray and self-control embodiment 2 are applied The epidemic situation comparison of used time, it is respectively from left to rightHydrochloric acid terbinafine emulsifiable paste,Hydrochloric acid terbinafine spray, Embodiment 2.

Specific embodiment

The above of the present invention is described further again below by way of specific embodiment, it is to be noted that These embodiments are merely to illustrate the present invention and not limited the scope of the invention, all skills realized based on the above of the present invention Art belongs to the scope of the present invention.

It is related to the method and composition for long-acting treatment dermatophytid infection in the method for the present invention.Such infection includes The fungal infection of skin superficial layer and deep fungal infection.

The invention provides a kind of composition of the skin-use preparation with new medicinal products dermal delivery and mechanism of action, Said composition realizes the long-acting treatment effect to dermatophytid infection in terms of two.

On the one hand it is of the invention innovative using skin as drug-reservoir, optimization formulation, adjust preparation passs medicine ability (passing drug effect rate), delivers drugs into skin targets position, it is ensured that medicine is detained for a long time in skin, and medicine is dense in skin Minimal inhibitory concentration of the degree more than medicine.To reach this purpose, the component and component ratio of the invention by adjusting preparation will Medicine delivers drugs into the position of skin targets in the stage (applying preparation in the process of skin-preparation film forming drying) of administration Put, while ensure that medicine is not transmitted through skin and enters blood by preparation controlled release means.Utilize the dynamic mistake of skin metabolism Journey, medicine is gradually pushed to skin superficial layer, until medicine is metabolized out skin.

For this purpose, the present invention is controlled by a variety of methods, promotes medicine to enter skin.Specific embodiment is： By the use of ethanol or isopropanol as a part for preparation in the mixed solvent, on the one hand accelerate composition in skin surface film forming, drying； On the other hand medicine is promoted to rapidly enter skin.Preferable component and component ratio such as embodiment 1.

Embodiment 1：

For some embodiments, (especially spray-filming agent, it is sprayed the amount of alcohol of single dose in the form of vaporific, second Alcohol largely volatilizees in air, causes the amount of alcohol insufficient) destination layer of skin can not be delivered drugs into.

The present invention adds transdermal enhancer to promote the absorption of medicine in prescription, and specific embodiment is azone class：Month Azone；It is surfactant-based：Sldium lauryl sulfate, Tween 80, polysorbas20, polysorbate40, Tween 80, Brij 30, Brij 35, Myrj 49, Myrj 51, Myrj 52, Myrj 53, Pluronic/Lutrol F 44, PLURONICS F87, poloxamer 237, poloxamer 338th, combination one or more in poloxamer188；Higher fatty acids and its esters：Oleic acid, linoleic acid, laurate, Pork and beans One or more combination in cool acid, linolenic acid, isopropyl cetylate, isopropyl myristic acid ester；Sulfoxide type and its class Like thing：In dimethyl sulfoxide (DMSO), dodecyl methyl sulfoxide, DMF, DMA, dimethyl sulfoxide One or more combinations；Pyrrolidinone compounds, such as one or more in α-pyrrolones, 1- N-methyl 2-pyrrolidone Ns, 5- N-methyl 2-pyrrolidone Ns Combination；Volatile oil, such as combination one or more in peppermint oil, eucalyptus oil, turpentine oil, borneol.Preferred embodiment is strictly according to the facts Apply example 2.

Embodiment 2：

The invention provides another method and alcoholic solution to deliver drugs into skin together.In certain embodiments, add Add gel matrix material, be embodied as：Carbomer 910, carbomer 934, Acritamer 940, carbomer940, Carbopol 941, Carbomer934；Cellulose derivative, such as CMC-Na, HPMC, HPC, SL-HPC, SSL-HPC are one or more in L-HPC Combination.More preferably combination one or more in HPC, L-HPC, SL-HPC, SSL-HPC.

Gel matrix material is added in prescription, can play a part of " pinning " alcoholic solution, upon administration, directly and air The part of contact, quickly forms thin film, and the alcoholic solution in the preparation between skin is pinned, this part alcoholic solution volatilization Slowly, medicine can be promoted to enter in deeper skin.In the particular embodiment, after being applied by preparation whether There is the feasibility that alcohol smell tentatively judges this method.Shown according to embodiment, be not added with the preparation of gel matrix material, applied Afterwards, 1min rapid film formations, there is no alcohol smell.It is different, the prescription of gel matrix material is with the addition of, after application, system Agent surface can also form one layer of smooth, smooth film, but have faint alcohol smell, and after a period of time, the smell disappears. The time length that the alcohol smell disappears pins the ability of alcoholic solution and the gas permeability positive correlation of film with gel.Preferred embodiment is： 3~embodiment of embodiment 5.

Embodiment 3：

Embodiment 4：

Embodiment 5：

The invention provides the method that another delivering medicine enters skin.In order to improve to deep dermatophytid infection Therapeutic effect is, it is necessary to allow medicine preferably to accumulate in skin corium, or accumulated in the basalis of epidermis.According to the physiology of skin Structure, not only it can preferably enter skin with fat-soluble but also with water-soluble structure medicine.The present invention adds in prescription Some amphipathic pharmaceutical carriers, medicine is taken the lead in being contained, while the medicine as transdermal enhancer auxiliary unentrapped enters again Enter skin.It is embodied as：Brij 30, Brij 35, Myrj 49, Myrj 51, Myrj 52, Myrj 53, poloxamer 124th, combination one or more in PLURONICS F87, poloxamer 237, Pluronic/Lutrol F 108, poloxamer188.It is it is preferred that real It is embodiment 6 to apply example.

Embodiment 6：

After various functions material is added, the viscosity of final preparation and other mode of appearance can change, according to trouble The compliance of person considers, it is preferred that the method for applying composition of the present invention includes as follows：Section Example is to spray Mode be sprayed on skin surface；Section Example is applied to skin surface, preferably spray film forming agent in a manner of being coated with, also It is spray-filming agent.

On the other hand the method for realizing the long-acting treatment effect of said preparation is the physical isolation effect of preparation.The present invention proposes Physical isolation effect refer to that preparation is applied after, one layer of complete, fine and close, smooth true film can be formed in skin surface.Once skin Skin is attacked by fungi, and fungi can be grown in clothing or shoes, and the film that preparation is formed can prevent skin from infecting fungi again.Together When, in the formulation, medicaments uniformity is scattered in or dissolved in the formulation, and after forming film, medicine can be distributed on film, to the external world Fungi has certain inhibitory action, and it is fungi-infected to be again prevented from skin in this way.

It is provided by the invention in the embodiment that some are free of gel-type vehicle, or the relatively low embodiment of gel-type vehicle content Composition can uniformly be sprawled with vaporific ejection, complete, fine and close, smooth film can be formed in 1min on skin, should Film can be attached on above skin well, have good rub resistance ability, while great waterproof effect, said composition film forming No alcohol smell or alcohol smell rapidly disappear afterwards.After film forming, film is immersed immediately in 37 DEG C of physiological saline, film will not it is damaged, Great waterproof effect.

In some contain the embodiment of gel-type vehicle, composition provided by the invention can be with vaporific ejection, in skin Uniformly to sprawl above, complete, fine and close, smooth film can be formed in 1min, the film can be attached on above skin well, With good rub resistance ability, while great waterproof effect, there is alcohol smell after said composition film forming.After film forming, by film immediately Immerse in 37 DEG C of physiological saline, film can be damaged.After the latter time of film forming, alcohol smell is disappeared, and film is immersed to 37 DEG C of life Manage in salt solution, film will not be damaged.

The research of the waterproof, crocking resistance of film is carried out with preparation made of prescription shown in embodiment 1.By manufactured preparation With vaporific, uniformly it is sprayed on above smooth slide, after drying to be filmed, the slide with film is submerged into water, made Fixed time point takes out, with film it is whether damaged, be dissolved as evaluation criterion, judge the water proofing property of film；In addition by the load glass with film Piece, with self-control gauze swab stick, water is soaked, is wiped back and forth on film three times, whether breakage is evaluation index with film, in formulation Time point is tested, and judges its rub resistance ability.Wear-resisting experiment is carried out to the film being immersed in water environment simultaneously, in formulation Time point is tested, its rub resistance ability of comprehensive descision, and three experiments all continue 24h, and details are as shown in table 1.

Table 1：The water resistance of the preparation film of embodiment 1 and the investigation of crocking resistance

Film is complete：■；Slightly there is film damaged：▲；Badly broken or dissolving：△.

In 24h experiment, film has no the phenomenon that damage is serious or dissolves.Membrane slide after 6h is soaked takes out, After water drying, water proofing property, the rub resistance ability of film are recovered substantially.

Embodiment 7

To commercially available preparationHydrochloric acid terbinafine emulsifiable paste,Hydrochloric acid terbinafine spray, embodiment 2 are carried out Using the comparison of state, as shown in figure 1, being respectively from left to rightHydrochloric acid terbinafine emulsifiable paste,Hydrochloric acid spy compares naphthalene Phenol spray, the state of preparation compares after embodiment 2 is administered.As shown in figure 1, emulsifiable paste does not have rub resistance effect extreme difference, not had There is waterproof action；Spray does not have rub resistance and waterproof action before the drying, and its drying time is more than 8min, has after drying The effect of certain rub resistance, but there is no waterproof action.The present invention, film forming, drying time are less than 1min, had after film forming good Waterproof and rub resistance ability, concrete condition is the same as above waterproof, abrasion-resistant experimental data.

Embodiment 8

Film formation time is tested, using the skin of dorsum of hand of volunteer subject as experiment attachment, preparation sprayed Bottle is uniformly sprayed on above the back of the hand, and twice, 100 μ L, calculate film formation time, such as table 2 every time for spray：The investigation of film formation time.

Table 2：The investigation of film formation time

Embodiment 12

Further the performance of film is evaluated, using water proofing property and rub resistance ability as main evaluation index.

By manufactured preparation with vaporific, uniformly it is sprayed on above smooth slide, after drying to be filmed, by the load with film Slide is submerged into water, is taken out at the time point of formulation, with film it is whether damaged, be dissolved as evaluation criterion, judge the water proofing property of film； In addition by the slide with film, with self-control gauze swab stick, water is soaked, is wiped back and forth on film three times, it is whether damaged with film For evaluation index, tested at the time point of formulation, judge its rub resistance ability.The film being immersed in water environment is entered simultaneously Row abrasive resistance is tested, and is tested at the time point of formulation, its rub resistance ability of comprehensive descision, as a result such as table 3：Embodiment 13, embodiment 14, shown in the water resistance of the preparation film of embodiment 15 and the investigation of crocking resistance.

Table 3：Embodiment 13, embodiment 14, the water resistance of the preparation film of embodiment 15 and the investigation of crocking resistance

Waterproof ability evaluation criterion：Film is complete：■；Slightly there is film damaged：◆；Badly broken or dissolving：□.

Rub resistance ability evaluation criterion：Film is complete：▲；Slightly there is film damaged：Badly broken or dissolving：△.

Comprehensive ability evaluation standard：Film is complete：●；Slightly there is film damaged：◎；Badly broken or dissolving：○.

In 24h experiment, film has no the phenomenon that damage is serious or dissolves.Membrane slide after 6h is soaked takes out, After water drying, water proofing property, the rub resistance ability of film are recovered substantially.

Claims (10)

1. a kind of hydrochloric acid terbinafine is used for the method and composition of long-acting treatment dermatophytid infection, it is characterised in that described Quality percent by volume of the component and each component of composition in whole solution is as follows：

(a) pharmacological active substance：0.1~20%,

(b) filmogen：0.1~15%,

(c) drug release material：0~15%,

(d) rate accelerating material：0.1~15%,

(e) nonessential excipient 0~10%,

(f) surplus is mixed solvent.

2. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, (a) pharmacological active substance is antimycotic medicine, preferably terbinafine and its salt, further preferably For hydrochloric acid terbinafine, its content is preferably：0.1~10%.

3. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, (b) filmogen is selected from one or more combinations of cellulose derivative, preferably ethyl cellulose Element, viscosity are combinations one or more in 7cp~100cp.

4. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, (c) drug release material mainly includes：Gel matrix material, one kind or more in drug carrier material The combination of kind.

5. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, (d) plasticizer is glycerine, polyethylene glycol, triethyl citrate, ATBC, three triacetins Ester, fractionated coconut oil, diethyl phthalate, dibutyl phthalate, SA dibutyl ester, the second of acetyl tributyl citrate three One or more combination in ester, tributyl 2-acetylcitrate, wherein the relative molecular weight of the polyethylene glycol be 200~ 6000。

6. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, (e) nonessential excipient, its classification, which includes, is not limited to one of following or combination：Penetration enhancer, Chelating agent, isotonic regulator, bacteriostatic agent, flavouring, antioxidant, ultra-violet absorber, ultraviolet light screener and physics hide the flaw One or more combination in material.

7. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, (f) mixed solvent is mixed solvents one or more in purified water, ethanol, isopropanol, one of which Or a variety of mixed solvent total contents includes respectively 10~99.4% (w/v) of total composition ethanol, isopropanol or its group The purified water of compound and 0~90% (w/v).

8. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, It is coated on characterized in that, the composition exists in the form of thick liquid, boehmite gel, gel and supensoid agent, during administration Skin surface.

9. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, described composition exists in liquid form, can also may be used so that the spray application of propellant need not be applied So that to need the aerosol application using propellant, after being applied to skin, one layer is formed in skin surface with vaporific ejection for preparation True film.

10. hydrochloric acid terbinafine according to claim 1 is used for the method and composition of long-acting treatment dermatophytid infection, Characterized in that, methods described provides a kind of skin-use preparation with new medicinal products dermal delivery and mechanism of action, institute State innovative delivering and mechanism of action is that it is initiative using skin as drug-reservoir, utilize the dynamic of skin metabolism Process, from inside to outside, medicine is pushed to skin superficial layer, ensures that affected area has effective dose of medicine thing, realizes long-acting suppression Bacterium acts on；At the same time, after preparation is applied, one layer of true film can be formed on focus surface, prevents that focus is fungi-infected again, Dual bacteriostatic acts on realizing physical isolation and Drug inhibition.