CN107635544A - Individual layer tooth whitening system - Google Patents
Individual layer tooth whitening system Download PDFInfo
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- CN107635544A CN107635544A CN201680010815.5A CN201680010815A CN107635544A CN 107635544 A CN107635544 A CN 107635544A CN 201680010815 A CN201680010815 A CN 201680010815A CN 107635544 A CN107635544 A CN 107635544A
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- peroxide
- coat composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/044—Suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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- Paints Or Removers (AREA)
Abstract
A kind of clear coat composition is provided, it includes the hydrophily oral cavity nursing agent of scattered peroxide material in the solution etc., and the solution is solution of the film forming hydrophobic polymer in non-polar solven.Solvent is selected as the good solvent for polymer and is easy to evaporate.Composition can be applied to individual layer varnish, preferably whitening varnish.For example, scattered hydrophily peroxide material is peroxide aqueous solution, such as hydrogenperoxide steam generator, wherein dispersion are emulsions.
Description
Technical field
The present invention relates to dental care art and association area, and more particularly relate to the varnish group of tooth-whitening
Compound and method.
Background technology
Oral cavity nursing agent can be applied to tooth via clear coat composition, and medicament is discharged into tooth by the clear coat composition
In.Such release occurs via water present in preparation, or enters in the moisture from tooth through the inner surface of varnish
Fashionable generation.The belt carrier that clear coat composition is used as to oral cavity nursing agent carrys out some advantages.Especially, by liquid varnish composition
Being applied on tooth to be easily accomplished.This is such as by smearing or such as by using its syringe, brush or spatula
His diffusion technique.
Particular advantage is can to avoid using dental tray or other invasive bringing devices, because clear coat composition can
To be smeared or be otherwise manually diffused on tooth.This is beneficial under professional care environment, but is also allowed
Patient or user oneself apply as oral care composition.
However, the wetting of the outer surface of varnish may cause oral cavity nursing agent also to be leaked into addition to entering in tooth
In mouthful (for example, towards lip), the amount for the oral cavity nursing agent for being delivered to tooth is thereby reduced.Clear coat composition is also likely to be soft
And easily wash off, the oral cavity nursing agent for being thus not allow for effect amount is delivered to tooth.The clear coat composition of deposition also may be used
There can be the rough surface that may stimulate lip and other soft tissues.In addition, the composition of deposition may have in coarse table
Undesirable outward appearance in terms of face, the color of difference and/or undesirable reflectivity properties.
Above mentioned problem is recognized in the art.One kind is refer in the A1 of US 2005/0249677 to be related to and will bleach group
Compound is directly applied to the method for bleaching on the tooth of people.Thus mention and apply that spread bleaching is that it is eliminated the advantages of perceiving
For the needs of dental tray, but apply spread bleaching composition major defect be it keep being directly exposed to people saliva and
The destructive power found in the mouth of people.In the reference, it is anticipated that dentistry bleaching composition is applied on tooth,
Apply protective composite on or near gingiva tissue and moisture barrier layer is placed on above the dental surface to be bleached.Screen
Barrier layer is the device with shape, such as in the form of dental tray, sheet material, band or paster.Therewith, wait to put by providing
Put the device with shape in mouth, if the reference be not all of also greatly reducing if reduction with via can
The composition on tooth is applied to apply the advantages of oral cavity nursing agent is associated.
In addition, double-deck whitening varnish can be obtained with trade name Philip Zoom QuickPro product.This is typically
In five minutes short dental clinic's programs.The product using 20% hydrogen peroxide whitening varnish based on being followed by several seconds
Dried in clock and hydrogen peroxide layer is locked to the bilayer technology of sealant layer in place.Although the product is in tooth whitening technology
Sizable progress is provided, but applied for some, be, for example, further to be easy to family to use it may be desirable to offer individual layer is clear
Paint.
It is expected to provide a kind of system and method, it can overcome existing such as before above-mentioned Zoom QuickPro products
Some in the problem of system, such as slip with the reduction in oral cavity nursing agent to mouth, but it is based entirely on varnish
Type composition.That is, a kind of system is sought, it is integrally based on to be readily applied on dental surface as fluid and this
The composition being cured afterwards.
The content of the invention
In order to preferably solve above-mentioned expectation, a kind of oral care clear coat composition is presented in the present invention in one aspect, wraps
The dispersion in the solution of hydrophily oral cavity nursing agent is included, the solution is film forming hydrophobic polymer in non-polar solven
Solution, the solvent be it is volatile and it is characterized in that as polymer than Xi Ta (θ) more preferable solvent.
On the other hand, the present invention provides a kind of layer of varnish of solidification at least one tooth, can be by walking as follows
It is rapid to obtain：Apply the varnish group for the dispersion in the solution for including hydrophily oral cavity nursing agent at least one tooth
Compound, the solution are solution of the film forming hydrophobic polymer in non-polar solven, and the solvent is volatile and it
It is characterized in solidifying the composition than Xi Ta (θ) more preferable solvent, and by the evaporation of solvent as polymer；It is described
The composition of solidification includes the hydrophily oral cavity nursing agent being dispersed in the matrix of hydrophobic polymer, and wherein hydrophily oral cavity is protected
Manage agent with coherent condition present at least at the composition of solidification at the surface of tooth, and the layer of hydrophobic polymer is extremely
Be present in less the composition of solidification at the surface of tooth.
Include it yet still another aspect, the present invention is a kind of applies oral cavity nursing agent to the method for tooth, method：Offer includes
The clear coat composition of the dispersion in the solution of hydrophily oral cavity nursing agent, the solution are film forming hydrophobic polymers non-
Solution in polar solvent, the solvent are volatile and it is characterized in that as more more preferable than Xi Ta (θ) for polymer
Solvent；An at least layer composition is applied at least one tooth；Evaporated with permission solvent so that clear coat composition solidifies.
Brief description of the drawings
Fig. 1 (a) to Fig. 1 (c) is the structure of the invention with the water peroxide being emulsified in hydrophobic polymer solution
The diagrammatic representation of think of；
Fig. 2 is the photo of the test sample of layer of varnish.
Fig. 3 is to depict the figure that the peroxide in the test compared with flank release is discharged with mouth side discharges
Table.
Fig. 4 is the whitening knot on the human teeth pulled for depicting composition of the invention compared with market standard
Fruit.
Embodiment
The invention allows to the hydrophily oral cavity nursing agent of hydrophily peroxide material etc. is retained in into tooth
On, without applying single barrier.According to the present invention, one layer of clear coat composition is applied on tooth, and then by permitting
Perhaps solvent is evaporated to dry (solidification).The present invention is applied to the suspension oral cavity nursing agent and such as mistake of solid peroxide etc.
Aoxidize both emulsions of water oral cavity nursing agent of aqueous solution of hydrogen etc..
The present invention is on hydrophily oral cavity nursing agent.Such medicament exists in form of an aqueous solutions, or with hydrophily
The form of particle is present.The representative illustration of such aqueous solution include hydrogen peroxide with various possible various concentrations in water
Solution.The representative illustration of hydrophilic particle includes urea peroxide and polyvinylpyrrolidone hydrogen peroxide adduct etc.
Solid peroxide.Other examples of hydrophily oral cavity nursing agent include being intended to other oral cavity nursing agents entered in tooth
(for example, remineralizing agent, fluorochemical agent, desensitizer).
The composition of the present invention includes film forming polymer the solution in volatile solvent.When the solvent evaporates, it is of the invention
Composition cause evaporation occur where side (that is, away from tooth) polymer film formation.The polymer film is used for
Make the water external environs (sealing) of hydrophilic active agent and mouth.The present inventor is not intended to be bound by theory, it is believed that can be with
Provide following explanation.
Hydrophobic polymer and nonpolar volatile solvent both phases different from scattered hydrophilizing agent.Applied
Composition surface at solvent evaporation when, non-polar solven is by towards along hydrophobic polymer and scattered hydrophilizing agent
The surface migration of both draggings.The hydrophobicity on surface is attributed to, scattered hydrophilizing agent will be from the region depletion.Hydrophobicity is gathered simultaneously
The concentration of compound is attributed to the evaporation of solvent and increased, and initially forms solid polymer membrane.This has a dual effect, that is,
The sealing of the water environment of medicament and mouth is further enhanced, and effectively increase the medicament in the place (that is, on tooth) of needs
Concentration.
It is required that solvent is nonpolar, and it is good solvent for hydrophobic polymer.Good solvent be wherein solute-
Solvent interaction is than solute-those more favourable solvents of solute interaction.This refers to so-called Xi Ta (θ) condition.According to
The theory received, polymer chain configuration are influenceed by solvent quality.Point between polymer segment and ligand solvent molecule
Sub- interphase interaction has associated interaction energy, and it can be positive or negative.For good solvent, polymer segments with
Interaction between solvent molecule is favourable on energy, and polymer coil will be caused to expand.For poor solvent,
Polymer-Polymer self-interaction is preferable, and polymer coil will shrink.The quality of solvent depend on polymer and
Both the chemical composition of solvent molecule and solution temperature.If the solvent just bad shadow to the volumetric expansion for being enough to offset exclusion
Ring, then meet Xi Ta (θ) condition.For given polymer-solvent pair, western tower condition, the temperature are met at a certain temperature
Referred to as Xi Ta (θ) temperature or Xi Ta points.Solvent at the temperature is referred to as western tower solvent.Make polymer be dissolved in it is good (than θ more
Well) in the case of in solvent, the interaction between polymer segments and solvent molecule will cause polymer coil to expand.Polymer
Chain is by using the configuration for being referred to as avoiding random walk certainly.Resulting chain expansion promotes the formation of close membrane.
θ points can be determined by methods known in the art.Especially, θ points can pass through light scattering or osmotic pressure
Measure to determine, the polymer for the colloidal dispersion that such as Donald H.Napper publish in academic press's (nineteen eighty-three) is steady
Fixedization (Polymeric Stabilization of Collodial Dispersions) the 3rd chapter " polymer solution thermodynamics
It is previously mentioned in (Polymer Solution Thermodynamics) ", (" Xi Ta points is saved with specific reference to the 3.2.7.2 of page 43
Determination (Determination of the theta-point) ").For the purposes of the present invention, rapidly side can be applied
Method.This includes referring to the method for those based on the temperature for measuring phase separation in the range of polymer concentration.Especially, Xi Ta
The volume fraction v in polymer in a solvent can be passed through2In the range of measure the temperature of phase separation to determine, 10-5≤v2≤
10-2.This produces data to generate curve map of the inverse temperature relative to the logarithm of the volume fraction of polymer.To log v2=0
Extrapolation produce 1/ θ value.
Preferably, film forming polymer and nonpolar volatile solvent are so chosen, so that causing desired non-porous poly-
Compound film.It should be understood that film completely cuts off better, hydrophily oral cavity nursing agent keeps can be used for playing goodly on tooth
It is acted on.
Especially, according to the invention it is preferred to choose the polymer and solvent combination for meeting following test (KI tests)：
- a thin layer (100 microns to 200 microns) varnish is applied in substrate (for example, glass plate)
- allow solvent to be evaporated under conditions of oral conditions (environment of slightly higher temperature) are imitated
- after evaporation is completed, a few drop test liquids are placed on the surface of dry layer of varnish
- test liquid is the KI colourless aqueous solution (0.5M).Contacted with hydrogen peroxide, form the I with dark brown color2
(I3 -).The level of coloring is the qualitative instruction through the leakage of the hydrogen peroxide of skin covering of the surface.
- standing assesses whether droplet changes colour after 30 minutes by visual inspection；
- at most moderate (light brown) is faded and indicates that polymer/solvent combination provides sufficient barrier.
Release to tooth can be tested using identical test liquid in a manner of adapting to.
After application and solidification, dry layer is peeled off and is inverted from substrate.Then, KI test liquids are applied to
Hydrogen peroxide should be discharged on the surface of tooth by desciccator diaphragm.
Fast and strong brown colouration indicates good release of the peroxide towards tooth.
The big mRNA differential display mRNA in color development on the layer both sides of the solidification principle of the present invention.
It is noted that above-mentioned test is carried out with peroxide, because this is provided so by the reaction with KI
Obvious colour fading.Obviously, the result that is simple and directly testing represents any hydrophily oral cavity nursing agent.
Once learning the present invention, those skilled in the art can just apply to be considered from technology known to coatings art.This is outstanding
It refers to the setting of the concentration of polymer and activating agent etc..
In coating technology, the property of drying layer (film) is generally relevant with pigment volume concentration (PVC) (PVC).At low PVC, deposit
There is the polymer film with some scattered granules of pigments.At high PVC, it can produce including having only existed a small amount of polymer
One layer of particle for being wrapped (but general porous) desciccator diaphragm.It is therefore so-called " critical from parameter known to coating technology
PVC(CPVC)”.This is ratio when space between particle is just filled up completely with by polymer.In the present compositions,
The homologue of pigment in coating composition will be oral cavity nursing agent.Those skilled in the art will also can determine to be protected for oral cavity
Manage " CPVC " of the scattered volume (scattered particle or droplet) of agent.In the present compositions, recommend to provide polymer
With the ratio of oral cavity nursing agent so that by analogizing, composition has " PVC " for being more than " CPVC ".It is believed that this facilitate
The droplet of aqueous phase is urged to be in contact with each other and contacted with surface in evaporation.
Instruct as further, with reference to the exemplified composition according to the present invention, illustrated in following table 1 in above-mentioned
Hold.
Table 1
The volume fraction of droplet in the composition is：
63.6/1.08/ (63.6/1.08+0.38/0.8+2.87/0.91+1.59/0.77+31.55/0.76=0.56 is solid
PVC is 63.6/1.08/ (63.6/1.08+0.38/0.8+2.87/0.91+1.59/0.77=0.91 in the layer of change.
The present inventor is not intended to be bound by theory, it is believed that principle of the invention can be further described bellow.Although
Explanation provides by way of example for solid peroxide and for peroxide aqueous solution, but it extends to other
Hydrophily oral cavity nursing agent.
When drying, solid particle will flocculate.They will touch one another and touch dental surface, while be kept as particle
It is constant.Enter in water fashionable, particle will start to decompose and discharge peroxide (this is generally acknowledged principle in itself).In peroxide water
In the case of solution, varnish is the emulsion with the droplet comprising peroxide.When drying, droplet initially will also touch each other
Touch.However, different from above-mentioned solid peroxide, these droplets can also coalesce (flowing to together) or expand on the surface of tooth
Dissipate.In the case of the emulsion, enough water be present in preparation itself, so in the absence of for starting the release of peroxide
The water from tooth needs.
In both cases, peroxide is closed and covered with environment by hydrophobic material.For passing through solvent
After the drying of evaporation, one layer of hydrophobic polymer be present in the clear coat composition of solidification on the surface of tooth.Two
In kind situation, the hydrophily peroxide material of initially scattered (suspend or emulsify) in hydrophobic polymer solution is at least admittedly
The composition of change forms aggregation at the surface of tooth.Its uncured state that is, suspension depending on clear coat composition
Thing or emulsion, aggregation include clustering to particle together or coalescing to droplet together.
Ground relevant with this, the clear coat composition for the solidification that the present invention is also resided at least one tooth, the group of the solidification
Compound can be by that will be applied at least one tooth and made by the evaporation of solvent according to the clear coat composition of the present invention
The composition solidifies to obtain.The composition of resulting solidification still includes being dispersed in the matrix of hydrophobic polymer
The hydrophily oral cavity nursing agent of peroxide material etc..However, the result as solidification process, and as at least one
The result of water environment at the surface of individual tooth, the composition of solidification in face of the side of tooth with going out in the side away from tooth
Existing difference.According to the present invention, as explained above at least solidification composition at the surface of tooth to assemble shape
The hydrophily oral cavity nursing agent of peroxide material etc. be present in state.At least solidification composition away from the surface of tooth
One layer of hydrophobic polymer be present in place.
The design of the present invention is schematically illustrated in Fig. 1.
Hydrophily oral cavity nursing agent of the present invention on applying hydrophily peroxide material etc..For being used as this hair
The example for the peroxide that whitening agent in bright clear coat composition (also referred to as " bleaching agent ") uses includes but is not limited to：Peroxide
Change hydrogen, urea peroxide, polyvinylpyrrolidone hydrogen peroxide adduct and other hydrogen peroxide complexes, alkali metal percarbonic acid
The persulfate of the perborate of salt, sodium perborate etc., potassium peroxydisulfate etc., calper calcium peroxide, zinc peroxide, peroxidating
Magnesium, strontium peroxide, peroxy acid and combinations thereof.This refer to include the water-based of peroxide or the otherwise liquid of polarity or
Solid.Its non-limiting example includes solution, urea peroxide or PVP and hydrogen peroxide of the hydrogen peroxide in water complex compound.
Hydrophily oral cavity nursing agent is dispersed in solution of the hydrophobic film-forming polymers in volatile nonpolar solvents.
It should be understood that in the case of liquid oral care agent, dispersion takes the subdivision droplet of oral cavity nursing agent in a solvent
The form of emulsion.In the case of solid oral care agent, dispersion will take the shape of the suspension of finely divided particulate in a solvent
Formula.
For tooth whitening application, clear coat composition will include bleaching agent.It should be understood that bleaching used herein
It itself is the compound of bleaching agent and the compound as bleach precursor that agent, which can be, and such as urea peroxide, it reacts or divided
Solution is to form the bleaching agent of hydrogen peroxide etc..Bleaching agent can be solid or liquid at ambient conditions.Liquid bleach
Include the peroxide of hydrogen peroxide in aqueous etc..Solid bleaching includes urea peroxide, and it is urea and mistake
Adduct (or stable mixture) (CH of hydrogen oxide4N2O-H2O2).The material is white crystalline solid, and it is dissolved in water
Its two kinds of compositions are formed with release.Urea peroxide includes the equivalent of 36.1wt.% hydrogen peroxide.For example, comprising
The clear coat composition of 16.6wt.% urea peroxides can discharge 5.9wt.% hydrogen peroxide.Solid bleaching can by with
The form of grain introduces, and thus particle is hydrophilic.
Hydrogen peroxide (or its precursor) can be typically in being enough to be in application to provide in the layer (when solidified) of tooth
The amount of the hydrogen peroxide of amount from 0.1wt.% to 50wt.% is present in clear coat composition, and especially in so that carrying
Peroxide for being equivalent at least 1wt.% hydrogen peroxide until 35wt.% hydrogen peroxide, preferably from 2wt.% to 25wt.%
Amount concentration.Typical concentration is 2wt.% to 8wt.%, is used especially for family, or 20wt.% to 25wt.%,
Especially for the application carried out by dental professional.It should be understood that in the case of the aqueous emulsion of hydrogen peroxide, peroxide
Concentration of the compound in aqueous emulsion droplet will be necessarily higher than desired concentration in entire combination thing.
Preferably, oral cavity nursing agent is liquid.It is highly preferred that in tooth whitening in the case of use, it is peroxidating
The aqueous solution of hydrogen.
After the solidification carried out by the evaporation of solvent, polymer serves as the binding agent for varnish.Polymer is into
Film, preferably to the degree of non-porous close membrane is formed during its solvent evaporation at evaporating surface, to want the tooth of whitening
Forming layer on tooth.Polymer is further hydrophobic, to serve as the screen for hydrophily oral cavity nursing agent and saliva
Barrier.Characterized by hydrophobic polymer is not mixed with water by it typically and preferably repels the trend of water.Polymer is categorized as hydrophobic
What property or hydrophily were well known to those skilled in the art, and be commonly used in the art.
The viscosity of the composition of the present invention can from just above solvent viscosity (generally below 1mPas) to exceeding
Change in 1000mPas wide scope.
Suitable film forming hydrophobic polymer is, for example, such as can (such as waterproof or water-fast suncream, kiss fall in cosmetics
Lipstick and nail polish) in the polymer that finds.Those skilled in the art understand the polymer used in above-mentioned application completely
Type, and will can use identical polymer in the clear coat composition of the present invention.
The example of hydrophobic polymer includes but is not limited to：Parleam, ethylene/propene/styrol copolymer, fourth
Alkene/ethylene/styrene copolymer (Penreco), alkylated polyvinyl pyrrolidone (for example, coming from Ashland), poly- Alpha
Alkene (for example, coming from New Phase Technologies), hydrogenated polycyclopentadiene (for example, coming from Kobo), polyvinyl
Ether (for example, coming from Phoenix Chemicals) or the polystyrene/diblock rubber sold with trade name Kraton are copolymerized
Thing.
Copolymer including polystyrene end blocks and polyisoprene or polybutadiene mid block can be with trade nameD is commercially available.Including embedding among polystyrene end blocks and poly- (Ethylene/Butylene) or poly- (ethylene-propylene)
The copolymer of section can be with trade nameG is commercially available.
Exemplary polystyrene base co-polymer includes can be with trade nameFG1901 and
Those copolymers that G1652 is obtained.FG1901 materials are the benzene second based on the styrene-content with about 30%
The transparent linear triblock copolymer of alkene and ethene/butadiene.G1652 materials are based on 30/70 benzene second
The transparent or semitransparent linear three block copolymer of the styrene and ethylene/butylene (SEBS) of alkene/rubber ratio.Kraton FG gather
Compound is the SEBS polymer with the maleic anhydride (MA) being grafted in rubber mid-block.Business Kraton FG polymer
MA with the 1.0wt.% being grafted on block copolymer to 1.7wt.%.Preferable preparation is to utilize Kraton
FG1901GT (based on styrene and the linear three block copolymer of ethylene/butylene with 30% polystyrene content),
G1701E (linear diblock copolymer of styrene and ethylene/propene based on the combinated styrene content with 35% mass) and
A1536HU (styrene-based and the straight chain triblock copolymer of ethylene/butylene, as undoped with powder provide).
The concentration of polymer in the composition depends on the property of the polymer/solvent systems of dissolving, for currently preferred
The Kraton from 0.5wt.% to 15wt.% used is generally from 0.1wt.% to 80wt.%.Composition can be wrapped further
Include adjuvant and additive, such as emulsifying agent, film forming agent (hydrophobic polymer), lubricant, emollient, thickener, filler, evaporation
Controlling agent, reinforcing agent for film forming etc..
In addition, clear coat composition can include additional oral cavity nursing agent and/or other additives.
The clear coat composition of the present invention includes one or more additional oral cavity nursing agents.
Preferably bleaching (whitening) agent as discussed above.Suitable for other parents used in the present compositions
Aqua is selected from by remineralizing agent, anti-caries agent, antiplaque block agent, deodorant, fluorochemical agent, antiseptic, biomembrane prevention or divided
The group that powder, pH adjusting agent, digital preservation composition, reactive enzyme, reactive group and combinations thereof are formed.Interesting
In embodiment, the one or more in above-mentioned medicament in addition to whitening agent also be present.
The particular example of oral cavity nursing agent includes：
Tartar controls (anti-tartar) agent：These can include phosphate and polyphosphate (for example, pyrophosphate), poly- amino
Propane sulfonic acid (AMPS), polyolefm sulfonates, polyolefin phosphates, such as azacycloalkyl -2,2- diphosphonate are (for example, azacyclo-
Heptane -2,2- di 2 ethylhexyl phosphonic acids), N- methyl azacyclopentane -2,3- di 2 ethylhexyl phosphonic acids, ethane -1- hydroxyl -1,1- di 2 ethylhexyl phosphonic acids (EHDP) and second
The salt of any of diphosphonate, phosphonoalkyl alkylene dicarboxylate and these reagents of alkane -1- amino -1,1- diphosphonates etc., example
Such as their alkali metal and ammonium salt and its mixture.
Fluoride sources：These can be used for example as anti-caries agent.Acceptable fluoride sources include on the oral cavity that can be used
Potassium, sodium and ammonium fluoride and mono-fluor phosphate, stannous fluoride, indium and its mixture.
Tooth and soft tissue desensitizer：These can include the stannous ion of halide and carboxylate etc., arginine,
Potassium citrate, potassium chloride, potassium tartrate, saleratus, potassium oxalate, potassium nitrate, strontium salt and its mixture.
Antimicrobial (for example, antiseptic) agent：These can include the acceptable antimicrobial in oral cavity, such as triclosan
(the chloro- 2- of 5- (2,4 dichloro benzene epoxide) phenol)；8-hydroxyquinoline and its salt, zinc and stannous ion source, such as zinc citrate；Copper
(II) compound, such as copper (II) chloride, fluoride, sulfate and hydroxide；Phthalic acid and its salt, such as adjacent benzene
Dioctyl phthalate monohydroxy magnesium；Sanguinarine；Quaternary ammonium compound, such as aikylpyridinium chloride are (for example, cetylpyridinium chloride
(CPC), the combination of CPC and zinc and/or enzyme, TPC and chlorination N- myristyl -4- ethylpyridines)；Bisguanides,
Such as CHG；Halogenated bisphenol compound, such as 2,2' di-2-ethylhexylphosphine oxides (the chloro- 6- bromophenols of 4-)；Benzalkonium chloride；
Salicylanilide, PBBs；Iodine；Sulfa drugs；Two biguanideses；Phenolic resin；The sub- derivative of piperidines, such as morphol and
Eight phenol；Extract of magnolia；Grape seed extract；Thymol；Eugenol；Peppermint；Geraniol；Carvacrol；Citral；Eucalyptus oil
Essence；Catechol；4- pi-allyl catechols；Hexyl resorcin；Gaultherolin；Antibiotic, such as enriching substance, A Moxi
Woods, tetracycline, fortimicin, minocycline, metronidazole, neomycin, kanamycins and clindamycin；And its mixture.Other
Useful antimicrobial is disclosed in United States Patent (USP) No.5,776,435.
Antioxidant：The acceptable antioxidant in oral cavity that can be used includes butylated hydroxyanisol (BHA), butyl
Change hydroxy-methylbenzene (BHT), vitamin A, carotenoid, vitamin E, flavonoids, polyphenol, ascorbic acid, herbal antioxidant,
Chlorophyll, epiphysin and its mixture.
Anti-plaque (for example, plaque rupture) agent：The acceptable antiplaque agent in oral cavity can include stannous, copper, magnesium and strontium salt, all
Such as the dimethicone copolyol of cetyl dimethicone copolyol, papain, glucoamylase,
Glucose oxidase, urea, calcium lactate, calcium glycerophosphate, polyacrylic acid strontium and its mixture.
Anti-caries agent：Its example includes tricalcium phosphate tricalcium phosphate and sodium trimetaphosphate.
Antiinflammatory：The acceptable antiinflammatory in oral cavity can include steroid dose, such as fluticasone and hydrocortisone, and
Non-steroidal drug (NSAID), such as ketorolac, Flurbiprofen, brufen, naproxen, Indomethacin, Diclofenac, support
Spend acid, Indomethacin, sulindac, tolmetin, Ketoprofen, fenoprofen, piroxicam, Nabumetone, aspirin, difluoro Buddhist nun
Willow, Meclofenamic Acid, mefenamic acid, oxygen protect raw element, phenylbutazone, and its mixture.
H2Antagonist：Available antagonist herein include Cimetidine, Etintidine, ranitidine, ICIA-5165,
Trembled alkane, Lamtidine, BL-6548, BMY- for fourth, famotidine, Roxatidine, pyrrole for pyridine, Du for than pyridine, ORF-17578, willow
25271st, it is neat cut down fixed, Buddhist nun replace for fixed, BMY-52368, SKF-94482, BL-6341A, ICI-162846, reflection allogene group,
Wy-45727, SR-58042, BMY-25405, Lovastatin, DA-4634, double sweet smell replace fourth, Shu Fu to replace, Ebrotidine, HE-30-
256th, D-16637, FRG-8813, FRG-8701, indoles bromo-amine, L-643728, HB-408.4, and its mixture.
Nutrient：Suitable nutrient includes vitamin, mineral matter, amino acid, protein and its mixture.
Preferable hydrophily oral cavity nursing agent is in addition to above-mentioned peroxide material, in addition to sodium fluoride, ACP
(amorphous calcium phosphate, including its calcium and phosphate precursor), potassium nitrate, potassium oxalate, phosphate and polyphosphate, single fluorophosphoric acid
Salt, amino fluoride, xylitol, Chlorhexidine (CHX), cetylpyridinium chloride (CPC), triclosan (Irgasan), fluorination are sub-
Tin (SnF2), zinc acetate, ammonium fluoride silver, hypochlorite, chlorine dioxide, iodine.
In interesting embodiment, composition of the invention includes being selected from by hydrogen peroxide, sodium fluoride, ACP, nitre
At least one oral cavity nursing agent for the group that sour potassium, potassium oxalate, CHX and CPC are formed.
As the example of other additives, clear coat composition can include it is following in one or more：
Colouring agent：Colouring agent can be selected to provide the film with white appearance or color and luster.
Tooth and soft tissue desensitizer：These can include the stannous ion of halide and carboxylate etc., arginine,
Potassium citrate, potassium chloride, potassium tartrate, saleratus, potassium oxalate, potassium nitrate, strontium salt and its mixture.
Anti-pollutant：Such as siloxane polymer.
Flavor enhancement：By way of example, any of flavor enhancement commonly used in toothpaste can be used.
Other possible additives include thermo-color and become colour additive.The additive of these types can enable a user to
When enough visually determination processing are completed.
Additional medicament and additive can exist with the amount that those skilled in the art generally know that if present.Allusion quotation
Type scope is from 0.5wt.% to 10wt.%, particularly from 2wt.% to 5wt.%.
The hydrophily oral cavity nursing agent of peroxide material etc., which is dispersed in solvent therein, has two main work(
Energy.One is binding agent of the dissolving for varnish.Another is to evaporate, with will pass through allow its solidify make it is varnish curing.
Due to the present invention clear coat composition in binding agent be hydrophobic polymer, so solvent be selected to it is nonpolar, it is as follows
What face further illustrated.Due to varnish solidification should by when composition is applied on tooth solvent from composition
Remove to occur, so removing can occur in the case where having heating or no heating.Preferably, evaporation is in environment temperature
Or slightly higher temperature (being usually 15 DEG C to 50 DEG C) place.Evaporation be from the generation of the surface of liquid become be not vaporized material saturation
Gas phase liquid vaporization type.Therefore, solvent is preferably volatile solvent, as will be described as further below.Air
Blow and can be used for stimulating evaporation.
In interesting embodiment, it can use for rigid gel but (warm at elevated temperature at room temperature
Coolant-temperature gage, such as 40 DEG C to 60 DEG C, typically about 50 DEG C) be fluid preparation.Such preparation will be to be heated to be carried
The temperature arrived applies, and solvent evaporation then also will easily occur at such temperature.
Solvent can substantially be classified into two classifications：Polarity and nonpolar.Solvent, its mixture and solvent and water
The polarity of mixture can be determined typically on the basis of the dielectric constant of solvent or solvent mixture.The water of high-polarity exists
Indicated at 0 DEG C with 88 dielectric constant.Solvent with the dielectric constant less than 15 is generally considered to be nonpolar.
The volatility of solvent depends on its boiling point and its vapour pressure.There is low boiling and high vapour pressure at environment temperature
Solvent typically will be volatile.Low boiling generally means that the boiling point (being 100 DEG C at 1atm) less than water.The steam of liquid
Pressure is the pressure with the steam of liquid equilibrium.Evaporation is intended to more quickly advance in the liquid with higher vapor pressure.It is excellent
Selection of land, choose following solvent：Its without clear coat composition not to prevent solvent too early from wrappage evaporate measure
In the case of the such high volatility that can not be wrapped.Those skilled in the art can enter one by adding one or more
The solvent of step adjusts the evaporation rate of solvent as needed, so that evaporation rate is reduced or increased.
Generally, volatile solvent by the boiling point with the boiling point close to water, and connects as used in this document
The vapour pressure of the vapour pressure of nearly water.The hardening time determined by the speed of the evaporation of solvent is typically between 10 seconds and 10 minutes.
It is contemplated that the longer time, but it is believed that can less receive for the people using solvent for more time.It is preferred that
Hardening time be from 20 seconds to 2 minutes, and it is special preferably in solvent can be with least can be suitable with the speed of ethanol
Speed evaporation, to produce the hardening time of about 30 seconds.
Preferable solvent includes the mixture of alkane, isoalkane, isoparaffin, siloxanes, fluorinated hydrocarbons and these solvents.
It should be understood that solvent used in the present invention should from for oral cavity using being selected in those acceptable solvents
Select.All possible selection can be different depending on supervision opinion for the solvent of even now, but those skilled in the art will not
Difficulty knows which solvent is acceptable.
Exemplary solvent has below general formula：CnH2n+1CmH2m+1, wherein n and m be independently greater than or equal to 1 and less than 9,
Or less than 5, and n+m<12 or<8.Solvent can be such as C4-C12Side chain or non-branched alkane, such as pentane, isopentane, heptan
Alkane, isoheptane, octane, isooctane, fluorated solvent, Cyclomethicone and combinations thereof.In a particular embodiment, solvent can be selected from
The group being made up of heptane, pentane and its mixture.
The example of solvent includes those listed in following table 2.Alkane forms very interesting embodiment, its
Middle heptane and isooctane are preferable.In interesting embodiment, isopentane is included in solvent mixture to subtract
Small hardening time.Isoparaffin is the substitute of technical attractive alkane.These are widely used in cosmetics, and
And with the trend more preferably received by consumer.
Table 2
The clear coat composition of the present invention preferably includes one or more emulsifying agents, so as in liquid peroxide material
In the case of help the formation of stable Water-In-Oil (w/o) emulsion.Suitable emulsifying agent includes but is not limited to Sorbitan alcohol ester
Fat ester, such as sorbitan monolaurate (Span 20), sorbitan monostearate (Span 60), dehydration mountain
Pears Sorbitane monooleate (Span 80), Arlacel-83 (Span 83), sorbitan isostearate
(Span 120), dioctyl sulfosuccinate (Aerosol OT100) are but it is also possible to be Hypermer B261's etc.
High molecular surfactant or such as Arlacel 1690 (sorbitan isostearate and the poly- castor oil acid of polyglycereol -3
Ester) etc. blended emulsifier.
The present invention also a kind of applies the hydrophily oral cavity nursing agent of teeth whitening etc. to tooth on providing
Method, method include providing such as the clear coat composition above described in all embodiments at least one tooth, and
Solvent is allowed to evaporate to solidify clear coat composition.
In the method for optimizing for applying hydrophily oral cavity nursing agent, oral cavity nursing agent is peroxide and method is tooth
Method for whitening.
Clear coat composition is applied to the tooth of pending human or animal.Composition can be by the dentistry of dentist etc.
Professional applies, or is applied by wearer.For example, composition can use such as pen, brush, foam block, cloth applicator,
The applicator of dental tray etc. applies to tooth, or is applied to two chamber syringes to form first layer.In other implementations
In example, composition can be inserted into applicator, such as insert in dental tray, and the applicator is adjacent to tooth and positions and connect
And be for example removed after partially dried/solidification of composition.
Composition can with for example from 25 μm to 500 μm, such as applied from the thickness of 50 μm to 300 μm, such as about 100 μm
It is added on tooth.In wherein hydrophily peroxide material in granular form some existing embodiments, film is big on thickness
In the average diameter of particle, the e.g. at least twice of the average diameter of such as particle or at least three times.This allows varnish solid
Smoothly arrive and touch during change.
After the time for the processing for being enough to realize the hydrophily oral cavity nursing agent progress using bleaching agent etc., remove
Layer of varnish.At the end of process cycle, the layer is for example, by it is peeled off and/or by brushing teeth and by from tooth from tooth
Remove.The process can repeat, such as one day, one week or once a month or frequent or less frequent progress.
In the case of tooth whitening, process cycle can refer to be enough at least a portion whitening for realizing tooth (such as
Change at least in 1 Δ E color) period.Δ E makes according to by the International Commission on Illumination definition of 1976 (CIE76)
With (represented before whitening with subscript 1) and whitening after L*, a*, b* value of tooth that (is represented with subscript 2) (it can be average value)
Calculated according to equation below：
L*, a*, b* value is known in the art.
In this respect, the present invention is also on a kind of method for making object, the more particularly tooth whitening of human subjects, side
Method include will apply such as the clear coat composition above described in all embodiments at least one tooth of the object,
Allow solvent to evaporate and held to form the layer of varnish of solidification and to allow the layer of varnish of solidification to be maintained at least one tooth
Continue desired process cycle.Preferably, process cycle have be enough to produce it is as defined above at least in 1 Δ E color
The length of change.Preferably, after process cycle, the layer of varnish of solidification is removed from tooth.It should be understood that whitening side
Method is beauty method.
In wherein hydrophily oral cavity nursing agent is the preferred embodiment of bleaching agent, the present invention further relates to a kind of making
The method of clear coat composition as described above.Method include make peroxide aqueous solution emulsify in non-polar solven with
The step of mixing solution of the emulsion with hydrophobic film-forming polymers in non-polar solven.Possible peroxide, polymer
It is as described above with solvent.Here, non-polar solven can be the mixture of single solvent or solvent, and it can be phase
It is same or different.For both peroxide emulsions and polymer solution, single solvent can be used.Preferable solvent is different
Alkane, they are mixtures.It is highly preferred that for the solvent of peroxide emulsions and polymer solution, (including solvent is mixed
Compound) it is identical.
Although being illustrated in detail in accompanying drawing and foregoing description and describing the present invention, such diagram and description should
It is considered illustrative or exemplary and not restrictive；The invention is not restricted to the disclosed embodiments.
For example, the present invention is operated in can having the embodiments of a variety of oral cavity nursing agents in the composition, and composition
Thus by the oral care function with more than one (for example, by whitening and remineralization, fluoride processing or desensitization etc.
One or more processing combination).
Those skilled in the art can be when putting into practice the present invention for required protection, to accompanying drawing, open and right of enclosing
It is required that research in understand and realize the disclosed embodiments other change.In the claims, word " comprising " is not excluded for
Other elements or step, and indefinite article "a" or "an" be not excluded for it is multiple.Remember in mutually different dependent claims
Carried some measures this it is pure the fact do not indicate that the combination of these measures cannot be used to advantage.It is any in claim
Reference shall not be construed to limit scope.
In a word, the invention particularly relates to a kind of clear coat composition, it includes scattered such as peroxide material in the solution
The hydrophily oral cavity nursing agent of material etc., the solution is solution of the film forming hydrophobic polymer in non-polar solven.Solvent is chosen
It is selected as the good solvent for polymer and is easy to evaporate.Composition can be applied to individual layer varnish, preferably whitening varnish.Example
Such as, scattered hydrophily peroxide material is peroxide aqueous solution, and such as hydrogenperoxide steam generator, wherein dispersion are breasts
Liquid.
Illustrate the present invention hereinafter with reference to the example below and accompanying drawing.Example and accompanying drawing are not intended to the model of the limitation present invention
Enclose.
In Fig. 1 (a-c), it is schematically shown design of the invention.There are reference marker following meanings (to be directed to peroxidating
Hydrogen is stated, but applies in general to other hydrophily oral cavity nursing agents)：
(1) there is water H2O2Emulsion droplet；
(2) there is the organic solvent of the hydrophobic polymer of dissolving；
(3) tooth；
(4) dry the solution of hydrophobic polymer；
(5) H is included2O2Coalescence water droplet；
(6) hydrophobic polymer layer obtained after drying.
In Fig. 1 (a), show to be applied in the uncured layer of varnish on tooth.In Fig. 1 (b), show in drying
The state of the varnish of period, wherein emulsion droplet coalesce.Dried result is shown in Fig. 1 (c), wherein coalesce
Emulsion droplet is shown as forming one layer on tooth, and the polymer solidified is formed on the surface of the layer of varnish of solidification and dredged
Water-based protective layer.
Example 1
Clear coat composition in isoparaffin
Highly enriched emulsion is made, to reduce the peroxide content in droplet.Therefore, use Ultra-It is even
Starch device by 15 grams dilution hydrogen peroxide (10wt% to 25wt%) 2.5 grams of 3.3wt.% the Span in Isopar E
83 (emulsifying agent) solution (C7-10Isoalkane mixture) in emulsify.
In a subsequent step, emulsion is made to be mixed with the concentration Kraton solution in Isopar E to make varnish.
Therefore, by 3 grams of concentrated emulsions and 0.6 gram of 13wt% in IsoparTMKraton FG1901GT mixing in E.Addition is about
0.6 gram of IsoparTME is to adjust viscosity.
In another sample, by 3 grams of concentrated emulsions and 2 grams of 5.5wt% in IsoparTMKraton G1701E in E are mixed
Close.For ease of mixing, varnish is heated to 40 DEG C to 60 DEG C.
Example 2
Clear coat composition in heptane
In the first step, 0.75 gram of water hydrogen peroxide (HP) is emulsified in heptane.HP solution is added to 3 grams
In solution of 1wt.% to the 5wt.% emulsifying agent in heptane.Using high shear impeller that is,T25 is completed
Emulsification.Secondly, solution of 1 gram of emulsion with 1 gram of 10wt.% Kraton FG1901 in heptane is mixed.Carefully mixing it
Afterwards, varnish is ready.Similarly, other clear coat compositions are made using the Kraton FG1901 in heptane.Below
Table 3 in provide example 2 composition general introduction.
Table 3
Example 3
Clear coat composition with different polymer
Similar to example 1, in isoparaffin (IsoparTME other clear coat compositions are made in).Emulsifying agent is Span 83.
These compositions are summarized in following table 4.
Table 4
Example 4
Protection and the test of release
By a thin layer varnish application on glass, and it is also coated with the paper tinsel table that easily can be removed from it after the drying
On face.Suitable paper tinsel is the pad for cohesive film.Pad can be thin by one additionally coated with polyethylene glycol etc.
Layer hydrophilic polymer, to imitate hydrophily dental surface.In this example, PEG1500 (polyethylene glycol) is dissolved in ethanol
1wt.%.
Cured layer on glass, which is used to test, to be protected.Cured layer on paper tinsel is stripped and is reversed for testing release.
Qualitative test is performed using KI solution, wherein the KI contacted with HP is attributed to I3- formation and become brown.This
It is illustrated in fig. 2.Wherein substrate of glass is at top, and paper tinsel is in bottom.
By the existence or non-existence coloured, the difference in the amount of the peroxide of release is obvious.Display is a small amount of
Peroxide discharged from the cured film in substrate of glass.This means the clear coat composition of the present invention can retain
Oxide.Also show, on hydrophily paper tinsel, discharged substantial amounts of peroxide.Therefore, clear coat composition of the invention is used for
Place (that is, on tooth surfaces) the release peroxide needed, and it is remained into the journey being not present on hydrophilic surface
Degree.
Institute can be quantitatively measured by the use of the Hannig determination methods as the known determination method discharged for peroxide
The amount of the peroxide of release.Thus cured layer is made with being received in the art as the good representative materials for saliva
PBS solution (phosphate buffered saline (PBS)) contact.
It is illustrated in figure 3 for the result of another test of the individual layer clear coat composition (SLV) of the present invention.
The test is used to be commented to the release in solution (water, buffer solution) according to the peroxide of time change by monitoring
Determine the separation of SLV composition.In order to evaluate the release in mouth；Varnish is applied to solid substrate and allows its solidification.Then
Varnish and substrate are immersed in the solution of stirring, and aliquot is taken out with fixed time interval and determined for peroxide concentrations.
In order to evaluate the release in mouth；Varnish is applied to anchoring base again and makes its solidification.Then by varnish exposed to sky
The surface of gas is attached on one piece of two-sided tape, and it is peeled off from the solid substrate where its formation and (exposes normal condition
Down should be with the surface of teeth contact).This of adhesive tape and varnish combination are attached to the second substrate (by means of two-sided tape), then
Submerged and determine peroxide release as described above.
Chart 3 in Fig. 3 is shown, in the experiment of 30 minutes, the flank of more peroxide from the varnish of solidification is (straight
Line) ratio discharges from mouth side (dotted line), as the purpose of the preparation of the present invention.
Example 5
The preparation of clear coat composition
Use UltraBy the 2.25 grams of 50wt% HP in water 1wt.% Span83 in 83wt.%
IsoparTMEmulsified in solution in the mixture of E and 17wt.% Permethyl 99As.By 2 grams in the emulsion and 0.5 gram of 20wt.%
Kraton G1643MS in IsoparTMSolution mixing in E.
Example 6
Whitening is tested
Compared with the whitening obtained using band (Crest strip for whitening band), two of the individual layer varnish according to the present invention are used
Kind preparation has carried out whitening test (the human teeth experiment pulled).Test bag is containing the processing of nine times 30 minutes (in mankind's mortar
On tooth).By recording L*a*b* values after rehydration (6 hours or overnight) to evaluate color.It is logical using being organized in for wetting
The rehydration completed in being tested for strip for whitening band is crossed in varnish experiment submerged in water.
As a result it is depicted in Fig. 4.Wherein two individual layer clear coat compositions rhombus (SLV1) and square of the invention
(SLV2) indicate.
Y-axis indicates the whitening effect (Δ E) in terms of the change in color in figure 3, and X-axis indicates processing
Number.The measurement point indicated with rhombus (◆) provides the result for band.With circular (●) and square (■) instruction
The measurement point gone out provides the result for being directed to SLV1 and SLV2 respectively.As illustrated, the individual layer clear coat composition of the present invention is realized
The white-skinned face function (SLV2) equivalent with band and it is more preferable the effect of (SLV1).
Claims (15)
1. a kind of oral care clear coat composition, include the dispersion in the solution of hydrophily oral cavity nursing agent, the solution
Solution of the film forming hydrophobic polymer in non-polar solven, the solvent be it is volatile and it is characterized in that as
The polymer is than Xi Ta (θ) more preferable solvent.
2. clear coat composition according to claim 1, wherein the dispersion is to include the hydrophily of solid peroxide
The suspension of particle.
3. clear coat composition according to claim 2, wherein the peroxide is selected from urea peroxide, PVP- hydrogen peroxide
Complex and its mixture.
4. clear coat composition according to claim 1, wherein the dispersion is the emulsion of the aqueous solution of hydrogen peroxide.
5. clear coat composition according to claim 4, including at least one emulsifying agent.
6. the clear coat composition according to any one of preceding claims, wherein the solvent is selected from by alkane, different alkane
The group that hydrocarbon, isoparaffin, siloxanes, the mixture of fluorinated hydrocarbons and these solvents are formed.
7. clear coat composition according to claim 6, wherein the solvent is selected from by heptane, isooctane and its mixture structure
Into group, alternatively mixed with isopentane or pentane.
8. the clear coat composition according to any one of preceding claims, wherein the polymer be styrene-based and
The linear three block copolymer of ethylene/butylene, and (SEBS), are alternatively grafted with maleic anhydride.
9. the clear coat composition according to any one of preceding claims, wherein the dispersion includes being selected from by being fluorinated
Sodium, ACP (amorphous calcium phosphate, including its calcium and phosphate precursor), potassium nitrate, potassium oxalate, phosphate and polyphosphate, single fluorine
Phosphate, amino fluoride, xylitol, Chlorhexidine (CHX), cetylpyridinium chloride (CPC), triclosan (Irgasan), fluorine
Change the oral cavity nursing agent for the group that stannous (SnF2), zinc acetate, ammonium fluoride silver, hypochlorite, chlorine dioxide, iodine are formed.
, can be by will be according to any one of preceding claims 10. a kind of layer of varnish of solidification at least one tooth
Described clear coat composition is applied at least one tooth and obtains the composition solidification by the evaporation of solvent
, the composition of the solidification includes the hydrophily oral cavity nursing agent being dispersed in the matrix of hydrophobic polymer, wherein described
Hydrophily oral cavity nursing agent with coherent condition present at least at the composition of the solidification at the surface of the tooth, and
And the layer of the hydrophobic polymer present at least at the composition of the solidification at the surface of the tooth.
11. a kind of apply oral cavity nursing agent to the method for tooth, methods described is included any in such as preceding claims
Clear coat composition defined in is provided at least one tooth, and allows the solvent to evaporate so that the clear coat composition
Solidification.
12. according to the method for claim 11, wherein the oral cavity nursing agent includes peroxide, methods described is tooth
Method for whitening.
13. the method according to claim 11 or 12, wherein the oral cavity nursing agent includes being selected from by sodium fluoride, ACP (nothings
Amorphous calcium phosphate, including its calcium and phosphate precursor), potassium nitrate, potassium oxalate, phosphate and polyphosphate, mono-fluor phosphate, ammonia
Base fluoride, xylitol, Chlorhexidine (CHX), cetylpyridinium chloride (CPC), triclosan (Irgasan), stannous fluoride
(SnF2), the medicament for the group that zinc acetate, ammonium fluoride silver, hypochlorite, chlorine dioxide, iodine are formed.
14. a kind of beauty method for making object, the preferred tooth whitening of human subjects, methods described include：It will be wanted according to right
The clear coat composition described in any one of 1 to 9 is asked to apply at least one tooth of the object, wherein the oral care
Agent includes peroxide；Allow the solvent evaporation to form the layer of varnish of solidification；With the layer of varnish guarantor for allowing the solidification
Hold and continue desired process cycle at least one tooth.
15. beauty method according to claim 14, wherein the process cycle has the face for being enough to produce at least 1 Δ E
The length of change on color, wherein Δ E are to be calculated using L*, a*, b* value of the tooth according to equation below：
Wherein described value is according to International Commission on Illumination 1976
The CIE76 values of the definition in year, wherein the described value represented with subscript 1 is before whitening, and the described value represented with subscript 2 is
After whitening.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15155444.1 | 2015-02-17 | ||
| EP15155444 | 2015-02-17 | ||
| PCT/EP2016/052100 WO2016131642A1 (en) | 2015-02-17 | 2016-02-02 | Single layer tooth whitening system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107635544A true CN107635544A (en) | 2018-01-26 |
| CN107635544B CN107635544B (en) | 2023-04-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680010815.5A Active CN107635544B (en) | 2015-02-17 | 2016-02-02 | Single layer tooth whitening system |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10307348B2 (en) |
| EP (1) | EP3259031B1 (en) |
| JP (1) | JP6532949B2 (en) |
| CN (1) | CN107635544B (en) |
| BR (1) | BR112017017398A2 (en) |
| RU (1) | RU2017132286A (en) |
| TR (1) | TR201908914T4 (en) |
| WO (1) | WO2016131642A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150342839A1 (en) | 2010-04-21 | 2015-12-03 | Oraceutica LLC | Compositions and methods for whitening teeth |
| CA3041126A1 (en) * | 2016-10-26 | 2018-05-03 | The Procter & Gamble Company | Kit for tooth whitening |
| WO2018132522A1 (en) | 2017-01-12 | 2018-07-19 | Colgate-Palmolive Company | Oral care composition for long-lasting peroxide delivery |
| FR3093419B1 (en) * | 2019-03-08 | 2021-06-18 | Univ Grenoble Alpes | Composition and associated method for measuring therapeutic compliance |
| JP2022526636A (en) * | 2019-04-16 | 2022-05-25 | ザ プロクター アンド ギャンブル カンパニー | A kit containing an electromagnetic radiation source and a semi-solid polyphase oral composition comprising hydrophilic bleach particles. |
| WO2021032574A1 (en) | 2019-08-20 | 2021-02-25 | Koninklijke Philips N.V. | Smart material based dental protection system |
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- 2016-02-02 BR BR112017017398A patent/BR112017017398A2/en not_active Application Discontinuation
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- 2016-02-02 TR TR2019/08914T patent/TR201908914T4/en unknown
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| US20180280259A1 (en) | 2018-10-04 |
| JP6532949B2 (en) | 2019-06-19 |
| RU2017132286A (en) | 2019-03-18 |
| EP3259031A1 (en) | 2017-12-27 |
| TR201908914T4 (en) | 2019-07-22 |
| BR112017017398A2 (en) | 2018-04-03 |
| EP3259031B1 (en) | 2019-04-10 |
| JP2018505164A (en) | 2018-02-22 |
| WO2016131642A1 (en) | 2016-08-25 |
| CN107635544B (en) | 2023-04-28 |
| US10307348B2 (en) | 2019-06-04 |
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