CN107616784A - A kind of wide field photoacoustic ultrasound mammary gland coronal scan imaging device and its method based on the detection of 1024 linear arrays - Google Patents
A kind of wide field photoacoustic ultrasound mammary gland coronal scan imaging device and its method based on the detection of 1024 linear arrays Download PDFInfo
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Abstract
The invention discloses a kind of wide field photoacoustic ultrasound mammary gland coronal scan imaging device and its method based on the detection of 1024 linear arrays, the device includes light source activation system, 1024 linear array detection systems, ultrasound and echo reception system, processing system, control system, image reconstruction display system and coronal scan system；The light source activation system and 1024 linear array detection systems are coupled by multimode fibre, collimater and homogenizer.During photoacoustic ultrasound bimodal imaging applications to mammary gland coronal scan are imaged by the present invention, coordinate motor scanning using the super large probe of 1024 array elements, the optoacoustic cofocus scanning to the imaging of wide field mammary gland coronal scan and different depth is realized, ensure that the high-resolution and high-contrast of image.
Description
Technical field
The invention belongs to technical field of imaging, more particularly to a kind of wide field photoacoustic ultrasound mammary gland based on the detection of 1024 linear arrays
Coronal scan imaging device and its method.
Background technology
Photoacoustic imaging technology refers to by short light pulse (pulsewidth<Microsecond) irradiation light absorbing medium after light energy is absorbed soon
Fast heating expansion, because exposure time is much smaller than by the heat conduction time according to media interior, generation transient thermal growths cause stress
Go out ultrasonic signal (being referred to as photoacoustic signal).The photoacoustic signal for answering medium to go out is received using sonac, and by certain
Calculation algorithm carry out image reconstruction, the distribution situations of organization internal light absorbs can be finally inversed by, it is a kind of to be inhaled based on optics
Receive the functional imaging technology of difference characteristic inverting tissue physiology lesion.
Mammary gland disease is increasingly paid attention to as common disease, the frequently-occurring disease of women by people.Modern breast cancer has a variety of
Technology, the photography of molybdenum target mammary X-ray is to penetrate mammary gland soft tissue using soft ray, reaches the purpose of observation mammary gland inner tissue.It is special
Point is easy, quick, no pain, accuracy rate height.The clear contrast of molybdenum target mammary X-ray photographs is suitable, can clearly show that
It is less than 1 centimetre of tissue in breast.But the photography of molybdenum target mammary X-ray belongs to the overlapping projection of tissue, therefore it is unfavorable for being accurately positioned,
And need to extrude breast when projecting.
Ultrasonic breast examination is using the ultrasonic signal of mammary gland reflection, reaches the purpose to breast imaging.This method can be clear
Each Rotating fields in clear display mammary gland, find lump in dense form mammary gland, and differentiate capsule and reality.And radiationless property, behaviour
Make simple, it is not necessary to extrude mammary gland, be suitable for teenager or pregnant lactation.But the accuracy of ultrasound is low, and sensitiveness is taken the photograph not as x-ray
Shadow, the tissue less than 1 centimetre is differentiated difficult.
CT galactophore scannings are typically frequently as the means of supplementing out economy of mammary X-ray photography and ultrasonic examination.The advantages of it is checked is close
It is high compared with mammary gland X photographies to spend resolution ratio, can not be limited by throwing according to position, conventional sweep scope is wide.But CT galactophore scannings is accurate
Property not as good as ultrasound, dose of radiation is big, and price is relatively expensive.Should not be as the preferred means of galactophore scanning.
MRI galactophore scannings, MRI imaging techniques due to fabulous soft tissue resolution and it is radiationless the characteristics of, to breast
Gland scanning imagery has original advantage, compensate for the limitation of mammary X-ray and ultrasound in some aspects, is mammary X-ray and super
The important supplement of sound mammary gland.MRI is multi-sequence im-aging, and inspection is relatively complicated, and the time is relatively long, while is breathed again
The interference of motion artifacts, have impact on picture quality to a certain extent, limit its promotion and application.
Because above-mentioned galactophore scanning imaging technique has different limitations, by photoacoustic imaging technology and wide variety of super
Acoustic imaging is combined and had a good application prospect." bowl formula optoacoustic breast imaging is scanned and its swept the A of patent No. CN 102512202
Retouch method " although in the bowl formula photoacoustic imaging scanner that refers to can carry out fast scan imaging to breast, can not with it is existing
B-mode ultrasonography device and data handling system combine, control and matching, complex process, it is necessary to additional customized bowl formula scan
The device and control system of instrument, are unfavorable for processing and manufacture.The resolution ratio of fault trend can not be obtained simultaneously.The patent No.
The photoacoustic imaging system that the A of CN 102573621 are referred to needs multifiber being attached on ultrasonic sensor, realize difficulty compared with
Greatly.Irradiated using laser and produce every straight line that the ultrasonic signal of framing needs complicated control to remove one two field picture of positioning, nothing
Method ensures the uniform of energy, does not realize the ultra dense degree array detection of (1) 1064 array element, and higher lateral resolution can be achieved；(2)
1064 arrays ensure that its sweep length can realize the most mammary gland coronal-plane examination of covering.
The content of the invention
The shortcomings that primary and foremost purpose of the present invention is to overcome prior art and deficiency, there is provided one kind is detected based on 1024 linear arrays
Wide field photoacoustic ultrasound mammary gland coronal scan imaging device.Another object of the present invention is to provide to be based on the detection of 1024 linear arrays
Wide field photoacoustic ultrasound mammary gland coronal scan imaging device imaging method.
The present invention uses following technical proposals：
The invention discloses it is a kind of based on 1024 linear arrays detection wide field photoacoustic ultrasound mammary gland coronal scan imaging device,
Including light source activation system, 1024 linear array detection systems, ultrasound and echo reception system, processing system, control system, image weight
Display system and coronal scan system are built, the light source activation system detects with ultrasound and echo reception system and 1024 linear arrays
System is connected, and the ultrasound is connected with echo reception system with 1024 linear array detection systems, control system and processing system, described
Again display system is connected image with processing system and control system, the coronal scan system and 1024 linear array detection systems
Connection；1024 described linear array detection systems and light source activation system are coupled by multimode fibre, collimater and homogenizer；
Described light source activation system, the coupling for pulse laser output light；Including pulse laser, energy light
Fine, fiber coupler and fibre bundle, the pulse laser, energy optical fiber, fiber coupler and fibre bundle sequentially coaxially connect；
1024 described linear array detection systems, for exporting the uniform line spot of energy, including 1024 array element linear arrays are visited
Head, fixture and cylindrical lens, fixture are fixed on 1024 array element linear array probe both sides, while coaxially connected with cylindrical lens；
Described ultrasound and echo reception system, for gathering echo-signal and processing, including ultrasonic wave transmitting with receiving,
Isolation amplification, samples storage and the Beam synthesis of echo-signal, are connected with computer successively；
Described processing system is used to become echo-signal dynamic filter and envelope detection, log-compressed and dynamic range
Change and Digital Image Processing；
Described control system include produce ultrasonic scan basic sequential, control front end ultrasound mode, channel gain and
The communication of computer；
Described image reconstruction display system, for rebuilding galactophore image simultaneously using the filter back-projection algorithm of limited angle
Shown and checked with graphical interfaces, by Three-dimensional Display software, photoacoustic imaging backprojection algorithm and Image Adjusting software to image
Rebuild；
Described coronal scan system, for carrying out automatic one-dimensional scanning, including one-dimensional stepper motor, machinery to breast
Arm and tank, mechanical arm connect one-dimensional motor and tank.
As preferable technical scheme, described light source activation system is transmitted by multimode fibre, and collimator collimates again
Homogenized to homogenizer；The homogenizer is made up of multiple different, individually controllable lenticule units, and Gauss light is converted to
The uniform flat-top light of energy, the rectangular light spot energy uniformity is exported up to 90%.
As preferable technical scheme, the switching of the data acquisition of ultrasound and photoacoustic imaging is cut by coronal scan system
Change, while the position reconstruction to having scanned goes out 3-D view.
As preferable technical scheme, 1024 described array element linear array probes are the super large linear array probes of 1024 array elements, battle array
First spacing is 0.2 millimeter, and probe length is 20.48 centimetres；One-dimensional scanning is carried out by stepper motor, realizes and whole mammary gland is preced with
The real time three-dimensional imaging in shape face, scanning range and imaging width cover whole breast.
As preferable technical scheme, the incident angle and cylindrical lens of 1024 described linear array detection systems adjustment light are burnt
Away from changing the focal length of acoustic lens in 1024 array element linear array probes, be achieved in the optoacoustic cofocus scanning of different depth.
As preferable technical scheme, described cylindrical lens length and fibre bundle beam splitting end spread length and 1024 array elements
Linear array probe length is identical, and focal length is 12 millimeters, launching spot is focused on cylindrical lens width, out-focus in length.
As preferable technical scheme, the processing system enters Mobile state using the bandpass filter of FIR filter design
Filtering, envelope detection afterwards obtain in-phase component and quadrature component using analog quadrature demodulation method, it is low-pass filtered after again
Data after AD conversion are carried out log-compressed and dynamic range transform by AD conversion, and the processing of image includes image interpolation, brightness
Conversion and image restoration.
As preferable technical scheme, the control system controls the scan patterns of 1024 array element linear array probes, passage
Time gain and computer communication, the control system delay different to all array elements of probe, the wave beam of control transmitting ultrasound, change
Become the gain of data different depth, coordinate each system and the data exchange of computer.
Present invention also offers a kind of wide field photoacoustic ultrasound mammary gland coronal scan imaging dress based on the detection of 1024 linear arrays
The imaging method put, comprises the steps：
(1) pulse laser is coupled to fibre bundle common port by multimode fibre, collimater and homogenizer, while pulse is swashed
Trigger signal access ultrasound and echo reception system, the line spot of light device incide breast through cylindrical lens；
(2) incident angle and cylindrical lens focal length are adjusted, while adjusting the focal length of lens makes optoacoustic confocal；
(3) patient's breast is flattened and be placed on below tank, 1024 array element linear array probes are immersed in the water scanning constant simultaneously
Original position；
(4) one-dimensional motor scanning is started, for motor to set step pitch scanning, each scan position switches two kinds of optoacoustic and ultrasound
The collection of signal；
(5) computer reconstruction goes out 3-D view after the completion of scanning.
As preferable technical scheme, whole breast is completely covered using the image of 1024 parallel array element collections, makes step
Stepper motor need to only do the two-dimensional scan mode that one-dimensional scanning just substitutes complexity, so as to ensure that the good uniformity of apparatus and method
And repeatability.
The present invention is had the following advantages relative to prior art and effect：
(1) present invention is popped one's head in using the super large of 1024 array elements, and one-dimensional scanning region and imaging region can cover whole breast
Room, avoids the two-dimensional motor scanning of complexity, and the imaging of whole mammary gland ensure that the repeatability and uniformity of height.
(2) the wide field photoacoustic ultrasound mammary gland coronal scan imaging device provided by the invention based on the detection of 1024 linear arrays,
Light focal position can be adjusted, realizes that the manual focusing of different depth and optoacoustic are confocal, combines the high-contrast of photoacoustic imaging
With the high-penetration depth of ultrasonic imaging.
Brief description of the drawings
Fig. 1 is the knot of the wide field photoacoustic ultrasound mammary gland coronal scan imaging device based on the detection of 1024 linear arrays of the present invention
Structure schematic diagram；Wherein, 1 is light source activation system, and 2 be ultrasound and echo reception system, and 3 be 1024 linear array detection systems, and 4 be control
System processed, 5 be coronal scan system, and 6 be processing system, and 7 be image reconstruction display system.
Fig. 2 is the structural representation of 1024 linear array detection systems and coronal scan system；Wherein, 8 be mechanical arm, and 9 are
The package casing of PS materials, 10 be one-dimensional motor, and 11 be 1024 array element linear array probes, and 12 be cylindrical lens, 13 be collimater and
Homogenizer, 14 be multimode fibre.
Fig. 3, which is that the optoacoustic of the wide field photoacoustic ultrasound mammary gland coronal scan imaging method based on the detection of 1024 linear arrays is confocal, to be swept
Retouch schematic diagram；Wherein, 15 be fibre bundle, and 16 be fixture, and 17 be cylindrical lens, and 18 be pulse echo signal, and 19 be different depth
Scanning object, 20 be 1024 array element linear array probes.
Fig. 4 is the fibre bundle matching of the wide field photoacoustic ultrasound mammary gland coronal scan imaging device based on the detection of 1024 linear arrays
The schematic diagram that linear array probe excites.
Fig. 5 is that the fibre bundle of the wide field photoacoustic ultrasound mammary gland coronal scan imaging device based on the detection of 1024 linear arrays is single
Optical fiber output energy accounting distribution map.
Embodiment
With reference to embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are unlimited
This.
Embodiment 1
With reference to shown in Fig. 1, the wide field photoacoustic ultrasound mammary gland coronal scan imaging of the invention based on the detection of 1024 linear arrays
Device, including light source activation system 1, ultrasound and the linear array detection system 3 of echo reception system 2,1024, control system 4, coronal-plane
Scanning system 5, processing system 6, image reconstruction display system 7.
With reference to shown in Fig. 2,1024 linear array detection systems of the invention and coronal scan system, including mechanical arm 8, PS materials
The package casing 9 of material, the one-dimensional array element linear array probe 11 of motor 10,1024, cylindrical lens 12, collimater and homogenizer 13, multimode
Optical fiber 14.The package casing and one-dimensional motor of mechanical arm connection PS materials are to fix original position, collimater, homogenizer and multimode
Optical fiber is sequentially coaxially connected, and laser coupled and energy are homogenized.Mechanical arm fixes original position during work, and laser passes through multimode
Optical fiber, collimater, homogenizer and the cylindrical lens output uniform line spot of energy, start one-dimensional motor driven probe towards one
Scanning direction carries out data acquisition, and 3-D view is reconstructed after the completion of collection.
With reference to shown in Fig. 3, a kind of wide field photoacoustic ultrasound mammary gland coronal scan based on the detection of 1024 linear arrays of the invention
Device, it is possible to achieve the optoacoustic cofocus scanning under different depth, wherein, 15 be fibre bundle, and 16 be fixture, and 17 be cylindrical lens,
18 be pulse echo signal, and 19 be the scanning object of different depth, and 20 be 1024 array element linear array probes.Fixture fixes fibre bundle
In 1024 array element linear array probe both sides, cylindrical lens be placed on it is coaxially connected before fibre bundle, to output light carry out line focus,
1024 array element linear array probes are placed on directly over scanning object and receive pulse echo signal.From the cylindrical lens of different focal,
The incident angle of incident ray hot spot is adjusted by fixture, hot spot can be made to focus on different depth；Area for sound,focal can then pass through choosing
Adjusted with the acoustic lens of different focal, it is possible to achieve optoacoustic is confocal and manual focusing, ensure that the flexibility of device.
With reference to shown in Fig. 4, a kind of wide field photoacoustic ultrasound mammary gland coronal scan based on the detection of 1024 linear arrays of the invention
Device, the uniform line spot for matching linear array probe are made up of fibre bundle and cylindrical lens, the laser of incidence end by collimater and
Homogenizer carries out the homogenization of laser energy, and the fibre bundle comprising 1,600 200 microns of core diameters is evenly distributed on probe both sides, often
The length of side arrangement and the length of linear array probe match, and the array element spacing of 1024 array elements is 0.2 millimeter, probe length
20.48 centimetres, 0.256 millimeter of the adjacent fiber spacing per side, optical fiber arrangement length is 20.48 centimetres, can well
With 1024 array element linear array probes.
With reference to shown in Fig. 5, a kind of wide field photoacoustic ultrasound mammary gland coronal scan based on the detection of 1024 linear arrays of the invention
The fibre bundle simple optical fiber output energy accounting distribution map of imaging method, the Energy distribution of line spot are uniform.
It is including as follows with the above-mentioned wide field photoacoustic ultrasound mammary gland coronal scan imaging method based on the detection of 1024 linear arrays
Step：
(1) pulse laser switch is opened, pulse laser is coupled to fibre bundle by multimode fibre, collimater and homogenizer
Common port, while pulse laser trigger signal is accessed into ultrasound and echo reception system, line spot is incident through cylindrical lens
To breast；
(2) incident angle and cylindrical lens focal length are adjusted, while the acoustic lens focal length for adjusting detector of sound makes optoacoustic confocal；
(3) patient's breast is flattened and be placed on below tank, while 1024 array element linear array probes are immersed in the water and have been fixed on
Beginning position；
(4) start one-dimensional scanning step motor, one-dimensional motor scan with certain step pitch, each scan position switching optoacoustic with
The collection of ultrasonic two kinds of signals；
(5) computer reconstruction goes out 3-D view after the completion of scanning；
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
- A kind of 1. wide field photoacoustic ultrasound mammary gland coronal scan imaging device based on the detection of 1024 linear arrays, it is characterised in that bag Include light source activation system, 1024 linear array detection systems, ultrasound and echo reception system, processing system, control system, image reconstruction Display system and coronal scan system, the light source activation system are with ultrasound and echo reception system and the detection of 1024 linear arrays System connection, the ultrasound are connected with echo reception system with 1024 linear array detection systems, control system and processing system, the figure Again display system is connected picture with processing system and control system, and the coronal scan system connects with 1024 linear array detection systems Connect；1024 described linear array detection systems and light source activation system are coupled by multimode fibre, collimater and homogenizer；Described light source activation system, the coupling for pulse laser output light；Including pulse laser, energy optical fiber, light Fine coupler and fibre bundle, the pulse laser, energy optical fiber, fiber coupler and fibre bundle sequentially coaxially connect；1024 described linear array detection systems, for exporting the uniform line spot of energy, including 1024 array element linear array probes, folder Tool and cylindrical lens, fixture are fixed on 1024 array element linear array probe both sides, while coaxially connected with cylindrical lens；Described ultrasound and echo reception system, for gathering echo-signal and processing, including ultrasonic wave transmitting is with receiving, echo Isolation amplification, samples storage and the Beam synthesis of signal, are connected with computer successively；Described processing system is used for echo-signal dynamic filter and envelope detection, log-compressed and dynamic range transform, with And Digital Image Processing；Described control system includes producing the basic sequential of ultrasonic scan, control front end ultrasound mode, channel gain and calculating The communication of machine；Described image reconstruction display system, for rebuilding galactophore image and using the filter back-projection algorithm of limited angle to scheme Shape interface display and check, image is carried out by Three-dimensional Display software, photoacoustic imaging backprojection algorithm and Image Adjusting software Rebuild；Described coronal scan system, for carrying out automatic one-dimensional scanning to breast, including one-dimensional stepper motor, mechanical arm and Tank, mechanical arm connect one-dimensional motor and tank.
- 2. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays Put, it is characterised in that described light source activation system is transmitted by multimode fibre, and it is even that collimator collimation arrives homogenizer progress again Change；The homogenizer is made up of multiple different, individually controllable lenticule units, and Gauss light is converted into the uniform flat-top of energy Light, the rectangular light spot energy uniformity is exported up to 90%.
- 3. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays To put, it is characterised in that the switching of the data acquisition of ultrasound and photoacoustic imaging is switched by coronal scan system, while to having scanned Position reconstruction go out 3-D view.
- 4. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays Put, it is characterised in that 1024 described array element linear array probes are the super large linear array probes of 1024 array elements, and array element spacing is 0.2 milli Rice, probe length are 20.48 centimetres；One-dimensional scanning is carried out by stepper motor, realizes real-time three to whole mammary gland coronal-plane Dimension imaging, scanning range and imaging width cover whole breast.
- 5. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays Put, it is characterised in that the incident angle and cylindrical lens focal length of described 1024 linear array detection systems adjustment light, change 1024 times The focal length of acoustic lens in first linear array probe, it is achieved in the optoacoustic cofocus scanning of different depth.
- 6. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays Put, it is characterised in that described cylindrical lens length and fibre bundle beam splitting end spread length and 1024 array element linear array probe length Identical, focal length is 12 millimeters, launching spot is focused on cylindrical lens width, out-focus in length.
- 7. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays Put, it is characterised in that the processing system carries out dynamic filter, bag afterwards using the bandpass filter of FIR filter design Network detection obtains in-phase component and quadrature component using analog quadrature demodulation method, it is low-pass filtered after AD conversion again, AD is turned Data after changing carry out log-compressed and dynamic range transform, the processing of image are answered comprising image interpolation, luminance transformation and image It is former.
- 8. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 1 based on the detection of 1024 linear arrays Put, it is characterised in that the control system controls scan pattern, the time gain of passage and the calculating of 1024 array element linear array probes Machine communicates, the control system delay different to all array elements of probe, the wave beam of control transmitting ultrasound, change data different depth Gain, coordinate each system and the data exchange of computer.
- 9. the wide field photoacoustic ultrasound mammary gland coronal-plane based on the detection of 1024 linear arrays according to any one of claim 1~8 is swept Retouch the imaging method of imaging device, it is characterised in that comprise the steps：(1) pulse laser is coupled to fibre bundle common port by multimode fibre, collimater and homogenizer, while by pulse laser Trigger signal access ultrasound and echo reception system, line spot incides breast through cylindrical lens；(2) incident angle and cylindrical lens focal length are adjusted, while adjusting the focal length of lens makes optoacoustic confocal；(3) patient's breast is flattened and be placed on below tank, 1024 array element linear array probes are immersed in the water scanning constant starting simultaneously Position；(4) one-dimensional motor scanning is started, for motor to set step pitch scanning, each scan position switches optoacoustic and ultrasonic two kinds of signals Collection；(5) computer reconstruction goes out 3-D view after the completion of scanning.
- 10. the wide field photoacoustic ultrasound mammary gland coronal scan imaging dress according to claim 9 based on the detection of 1024 linear arrays The imaging method put, it is characterised in that whole breast is completely covered using the image of 1024 parallel array element collections, makes stepping electric Machine need to only do the two-dimensional scan mode that one-dimensional scanning just substitutes complexity, so as to ensure that the good uniformity of apparatus and method and can Repeatability.
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| CN111028337A (en) * | 2019-12-04 | 2020-04-17 | 南京大学 | Three-dimensional photoacoustic imaging method for improving problem of limited visual angle |
| CN111358465A (en) * | 2020-03-19 | 2020-07-03 | 深圳大学 | Magnetic acoustic electric imaging system and method based on filtering inverse projection |
| CN111358465B (en) * | 2020-03-19 | 2022-11-18 | 深圳大学 | Magnetic acoustic electric imaging system and method based on filtering inverse projection |
| CN111772581A (en) * | 2020-06-11 | 2020-10-16 | 华南师范大学 | High-sensitivity photoacoustic/ultrasonic dual-mode imaging device and method based on double-curvature linear array detector |
| CN111772581B (en) * | 2020-06-11 | 2023-03-28 | 华南师范大学 | High-sensitivity photoacoustic/ultrasonic dual-mode imaging device and method based on double-curvature linear array detector |
| CN117218433A (en) * | 2023-09-13 | 2023-12-12 | 珠海圣美生物诊断技术有限公司 | Household multi-cancer detection device and multi-mode fusion model construction method and device |
| CN116942200A (en) * | 2023-09-20 | 2023-10-27 | 杭州励影光电成像有限责任公司 | Non-multiplexing ultrasonic multi-mode imaging system and method |
| CN116942200B (en) * | 2023-09-20 | 2024-02-06 | 杭州励影光电成像有限责任公司 | Non-multiplexing ultrasonic multi-mode imaging system and method |
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