CN107614036A - Portable medication injection device - Google Patents

Portable medication injection device Download PDF

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Publication number
CN107614036A
CN107614036A CN201680027691.1A CN201680027691A CN107614036A CN 107614036 A CN107614036 A CN 107614036A CN 201680027691 A CN201680027691 A CN 201680027691A CN 107614036 A CN107614036 A CN 107614036A
Authority
CN
China
Prior art keywords
cartridge case
medicine
discharge device
piston
medicine discharge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680027691.1A
Other languages
Chinese (zh)
Inventor
盖德·沙南
马克·高曼
布鲁斯·巴斯比
亚历克斯·马努利斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Excellent Fei Meter Te Ltd
YOFIMETER LLC
Original Assignee
Excellent Fei Meter Te Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Excellent Fei Meter Te Ltd filed Critical Excellent Fei Meter Te Ltd
Publication of CN107614036A publication Critical patent/CN107614036A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/1684—Monitoring, detecting, signalling or eliminating infusion flow anomalies by detecting the amount of infusate remaining, e.g. signalling end of infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31526—Dosing by means of stepwise axial movements, e.g. ratchet mechanisms or detents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
    • A—HUMAN NECESSITIES
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    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
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    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3114—Filling or refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A—HUMAN NECESSITIES
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    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3515—Communication with implanted devices, e.g. external control using magnetic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
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    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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    • G—PHYSICS
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    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
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    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Medicine discharge device may include：Recess, it is configured to receive the cartridge case with piston component and drug cavity；And gear assembly, it is configured to cause the piston component displacement to distribute medicine or by medicine intake chamber.Gear assembly can be started by electric motor starter structure and manual actuation mechanism.

Description

Portable medication injection device
Technical field
The present invention relates to medicament delivery device, more particularly, to electronic injection device.
Background technology
Diabetes are one group of diseases of metabolism related to hyperglycaemia, for example, it may be possible to because of insulin caused by body not Foot or cell carry out inappropriate response to caused insulin and caused.In the presence of three kinds of major type of diabetes.Class The diabetes of type 1 be derived from body production insulin failure, and need at present personal insulin injection (for example, manually or Use wearable insulin pump).The diabetes of type 2 are derived from insulin resistance, and pancreas islet can not be suitably used in wherein cell Element, sometimes in combination with there is absolute insulin deficit.The diabetes of Class1 and type 2 are considered as can not curable chronic case. The situation in not previous diabetes history in gravid woman can occur for the third principal mode (being referred to as gestational diabetes) Under when developing into elevated blood glucose levels, for example, this can develop into the diabetes of type 2, but be that typically in after the gestational period and solve.Its It is related that the diabetes of his form include congenital type ii diabetes (for example, genetic defect due to insulin secretion), cystic fibrosis Diabetes, the single-gene diabetes of steroid diabetes (for example, glucocorticoid due to high dose) and other forms.
For example, diabetes may cause acute complicationses in the case of no suitably treatment, it may for example comprise hypoglycemia, Diabetic ketoacidosis or Non-ketotic hyperosmolar coma, or in some cases, serious long-term complications may be caused, For example, angiocardiopathy, chronic renal failure and/or diabetic retinopathy (retinal damage).Therefore, suitably treat Diabetes and control blood pressure and managerial life mode (such as, the body weight of non-smoking and health) are important.Use pancreas The all multi-form diabetes of island extract for treating, include the diabetes of Class1.Use the diabetes of other drugs treatment type 2.In the presence of It is modified to the demand of the medication injection device of insulin injection and other drugs.
The content of the invention
The aspect of the present invention distributes the system, apparatus and method of medicine using electronic medicament injection device.
It is medicine discharge device on one side.Medicine discharge device includes recess, gear assembly, the first sliding component And motor, wherein, recess is configured to receive removable cartridge case, and the first sliding component is attached to gear assembly and including cartridge case The rotation of piston coupling member, wherein gear assembly is configured to cause the lengthwise movement in recess of the first sliding component, motor Gear assembly is attached to, the startup of motor is configured to cause gear assembly to rotate.
In some embodiments, the first sliding component includes female threaded shaft and medicine discharge device also includes and interior spiral shell The elongated screw member of line axle thread engagement, wherein, elongated screw member is attached to gear assembly so that the rotation of gear assembly Cause elongated screw member to rotate, thus cause the first sliding component lengthwise movement.
In some embodiments, cartridge piston coupling member includes being configured to the T-shaped part for receiving cartridge piston component Groove.
In some embodiments, the T-shaped part that groove is configured to allow cartridge piston component is in latched position and unblock In groove internal rotation between position, wherein, when in locking position, the retraction of the first sliding component makes cartridge piston component contract Return；And when in the unlocked position, the first sliding component is disengaged from cartridge piston component and first sliding component Retraction does not make cartridge piston component retract.
In some embodiments, medicine discharge device includes the manual distribution with bonding station and disengaged position Actuator, wherein, when in the engaged position, in the case where motor is without starting, the motion of distribution actuator causes tooth manually Wheel assembly rotates；And when in disengaged position, distribute actuator manually and be not attached to gear assembly.
In some embodiments, distribution actuator biases in disengaged position manually.
In some embodiments, distribution actuator can move in the case where not operating any other actuator manually To bonding station.
In some embodiments, distribution actuator includes the second sliding component manually.
In some embodiments, the first position of the second sliding component is disengaged position, and second slides structure Part is configured to slide into the second place as bonding station, and the further slip of the second sliding component causes gear assembly to revolve Turn.
In some embodiments, medicine discharge device includes being carved with rotatable counter wheel and the counting of multiple numberings above Wheel opening, wherein counter wheel opening is configured to provide for the observability of one in multiple numberings.
In some embodiments, counter wheel is attached to distribution actuator manually, wherein the actuating of distribution actuator manually Cause one or more discontinuous medication amounts to be distributed, and cause counter wheel to rotate, so that in counter wheel opening Visible numbering indicates the numbering of distributed one or more discontinuous medication amounts.
In some embodiments, gear assembly includes manual actuation gear and one or more motorized motions gears, hand Dynamic drive gear is attached to one in motorized motions gear, wherein, when in the engaged position, distribute the fortune of actuator manually Dynamic to cause manual actuation gear to rotate, the rotation of wherein manual actuation gear causes motorized motions gear to rotate, wherein electronic drive The rotation of moving gear causes the first sliding component lengthwise movement.
In some embodiments, motor is configured to make gear assembly rotate in forward direction and opposite direction, wherein Rotation of the gear assembly in forward direction causes the first sliding component to proceed in recess, and gear assembly is in phase negative side Upward rotation causes the first sliding component to be retracted to the outside of recess.
In some embodiments, rotation of the gear assembly in forward direction causes cartridge piston component towards cartridge case Access end advances, and the advance of wherein piston component towards the access end of cartridge case causes the access end in cartridge piston component and cartridge case Between fluid be distributed from cartridge case, the wherein rotation of gear assembly in the opposite direction causes cartridge piston component away from cartridge case Access end retract, the retraction of wherein access end of the cartridge piston component away from cartridge case causes the access end of cartridge case to draw fluid into In cartridge case.
In some embodiments, medicine discharge device includes user interface and processor, wherein, user interface includes matching somebody with somebody The display of the display data related to distributing medicine from medicine discharge device is set to, user interface is additionally configured to receive user couple The selection of the amount of medicine；Processor is configured to receive data from user interface, and processor is configured to indication motor drive gear set Part.
In some embodiments, medicine discharge device includes power supply.
In some embodiments, medicine discharge device include be configured to the first sliding component one of length travel or Multiple sensors.
In some embodiments, one or more sensors include electronic caliper, magnetic sensor, timer, bar shaped One or more of code scanner or RF readers.
In some embodiments, medicine discharge device includes communication module, and wherein communication module is configured to set to outside Standby transmission data.
In some embodiments, external equipment is analyte monitoring equipment.
In some embodiments, user interface is configured to show time, battery status, wireless communication state, first prodrug One or more of time, the medication amount in bottle and recommended dose of thing distribution data.
In some embodiments, medicine discharge device includes being configured to one that detects position of the cartridge case in recess Or multiple sensors, be configured to detect injection event one or more sensors and be configured to limitation when cartridge case be in note Penetrate the processor of the number for the injection event that can perform when in position.
In some embodiments, in response to detecting that cartridge case moves away from injection position, processor is configured to retraction the One sliding component, wherein the first sliding component is disengaged from cartridge piston component and does not make cartridge piston component retract.
In some embodiments, medicine discharge device includes the removable cartridge case in recess, removable cartridge case Including：Chamber, it is configured to medicament storage wherein；Piston component, it is positioned in chamber, is configured to longitudinally move in chamber Dynamic, wherein piston component is attached to cartridge piston coupling member；And separator, it is configured to receive pin.
In some embodiments, piston component includes piston seal and piston insert, and wherein piston insert joins It is connected to cartridge piston coupling member.
In some embodiments, piston insert includes being attached to the T-shaped part of cartridge piston coupling member.
In some embodiments, removable cartridge case includes the lug extended from the outer wall of removable cartridge case, its convexity Ear is configured to allow removable cartridge case in recess internal rotation, wherein rotation of the removable cartridge case in recess allows can be removed Cartridge case couples and disconnected with the first sliding component.
In some embodiments, medicine discharge device extends at least partly into the switch in recess, switchgear distribution To detect cartridge case existence in recess.
In some embodiments, medicine discharge device includes electronic distribution actuator, wherein electronic distribution actuator is matched somebody with somebody It is set to and activates motor in the case where applying external pressure to electronic distribution actuator.
A kind of further aspect is that external member.External member includes medicine discharge device and medicine fill tool, and wherein medicine is filled Instrument includes being configured to be attached to the adapter member of the end of medicine discharge device and is attached to adapter member and matches somebody with somebody The hollow circular cylinder for receiving medicine bottle is set to, wherein, fill tool, which is shaped to, causes position of the medicine bottle in hollow circuit cylinder body Putting makes medicine bottle and any cartridge alignment in recess and recess.
Further aspect is that the method for operating medicine discharge device.This method includes：Cartridge case is inserted in recess, Cartridge case include be configured to by medicament storage chamber wherein, be positioned in chamber and be configured to can in chamber it is longitudinally movable Piston component and end positioned at chamber separator；By in one end insertion separator of needle assemblies；By needle assemblies Opposite end insertion is accommodated in the medicine bottle of medicine；Medicine is sucked in the chamber of cartridge case from medicine bottle by needle assemblies；And pass through pin Distribute medicine from cartridge case.
In some embodiments, this method includes starting motor to perform from medicine bottle absorption medicine and distribute medicine from cartridge case One or more of thing.
In some embodiments, this method using user interface treat from medicine bottle draw medication amount and treat from One or more of medication amount of cartridge case distribution is programmed.
In some embodiments, this method includes detecting the generation of injection event via one or more sensors.
In some embodiments, this method includes display data on the user interface.
In some embodiments, this method is included to outside equipment transmission data.
In some embodiments, this method includes：Cartridge case is positioned in injection position, wherein medicine discharge device is matched somebody with somebody It is set to so that preventing injection event if cartridge case is not in injection position；Cartridge case is detected via one or more sensors In the existence of injection position；The generation of one or more injection events is detected via one or more sensors；And work as medicine The number for the injection event that limitation can occur when cylinder is in injection position.
In some embodiments, this method includes the piston component of cartridge case coupling structure with the piston of medicine discharge device Part couples, wherein distribution medicine includes making piston component in the inside of cartridge case advance, piston component is advanced includes making medicine point The piston coupling member for sending out equipment advances；And cartridge case is moved to outside injection position, wherein being moved to injection in response to cartridge case Outside position, piston coupling member disconnects from piston component and retracted automatically in the case where not making piston component retract.
Further aspect is that for the cartridge case used in medicine discharge device.Cartridge case includes：Chamber, it is configured to medicine It is stored therein；Piston component, it is positioned in chamber, is configured to vertically move in chamber, wherein piston component includes piston Seal and piston insert, wherein piston insert are configured to couple with the cartridge piston coupling member of medicine discharge device； Lug, extend from the outer wall of cartridge case, wherein lug is configured to the recess inward turning for allowing removable cartridge case in medicine discharge device Turn, wherein rotation of the removable cartridge case in recess allows removable cartridge case to couple and disconnect with cartridge piston coupling member； Ridges, extend from the outer wall of cartridge case, wherein ridges are positioned to allow for starting the switch inside medicine discharge device；And point Spacing body, it is configured to receive pin.
Further aspect is that the method for operating medicine discharge device.This method includes：By cartridge case insertion medicine distribution In the recess of equipment, cartridge case includes being configured to by medicament storage in chamber wherein and is positioned in chamber and is configured to Longitudinally movable piston component in chamber, conduit is fixed to one end of cartridge case；Start motor to distribute medicine from cartridge case；With And medicine is distributed from cartridge case by conduit.
In some embodiments, this method treats the medication amount distributed by conduit from cartridge case using user interface And one or more of time span of the distribution medication amount is programmed.
Brief description of the drawings
Fig. 1 shows to be configured for distributing the stereogram of the illustrative embodiments of the injection device of medicine.
Fig. 2 shows the stereogram of the illustrative embodiments of injection device.
Fig. 3 shows the stereogram of the illustrative embodiments of injection device.
Fig. 4 A show the stereogram of the illustrative embodiments of cartridge case.
Fig. 4 B show the sectional view of the embodiment of cartridge case.
Fig. 5 shows the rearview of the illustrative embodiments of injection device.
Fig. 6 shows the rearview of the illustrative embodiments of the inside of injection device.
Fig. 7 shows the sectional view of the illustrative embodiments of injection device.
Fig. 8 A show the sectional view of the illustrative embodiments of injection device.
Fig. 8 B show the sectional view of the illustrative embodiments of injection device.
Fig. 8 C show the sectional view of the illustrative embodiments of injection device.
Fig. 9 A show the Local map of the illustrative embodiments of injection device.
Fig. 9 B show the Local map of the illustrative embodiments of injection device.
Fig. 9 C show the Local map of the illustrative embodiments of injection device.
Fig. 9 D show the Local map of the illustrative embodiments of injection device.
Figure 10 shows the stereogram of the illustrative embodiments of injection device.
Figure 11 shows the schematic diagram of the illustrative embodiments of injection device.
Figure 12 shows to remove the illustrative embodiments of the injection device of several external modules.
Figure 13 shows to remove the illustrative embodiments of the injection device of several external modules.
Figure 14 shows to remove the illustrative embodiments of the injection device of several external modules.
Figure 15 shows the illustrative embodiments of the counter wheel for being used in injection device.
Embodiment
Arrive as will be understood by those skilled, the medicine for performing the embodiment according to present invention disclosed herein be present All multimodes of the example of thing conveying equipment, improvement and arrangement.Although by the exemplary reality to being shown in the accompanying drawings and the description below The mode of applying is referred to, but these embodiments do not mean that for the various alternate designs that are covered by disclosed invention and Embodiment is detailed.Those skilled in the art will readily appreciate that, without departing from the present invention, can carry out each Kind is changed and can carry out various combinations.
Some embodiments provide utilizes portable medication injection device injection single dose according to the amount that user inputs The system of medicine, method and apparatus.
In one embodiment, there is provided be configured to manage the portable medication injection device of medicine, the medicine is all Such as insulin can be expelled to any other medicine in patient by electric injection.Portable medication injection device may include For receiving cartridge case, gear assembly, motor, driving screw, slidingtype hand injection button, user interface, processor, power supply and leading to Believe the chamber of module.The engageable electric gear to gear assembly of motor.Gear assembly is engageable to driving screw.Driving screw can join It is connected to the nut (screw nut) including axle and is configured to the piston coupling member coupled with the piston component of cartridge case.
The startup of motor can cause gear assembly to rotate.The rotation of gear assembly can cause driving screw to rotate.Driving screw Rotation can cause nut vertical shift, so as to cause piston component to shift.Displacement of the piston component in cartridge case can cause medicine Distribute or enter in cartridge case from cylinder.The amount for the medicine being distributed using the interface selection of injection device.Processor can from Family interface data and it may indicate that motor-driven gear component.When the button on startup portable medication injection device, touch When sending out device or other actuating mechanisms, motor can be started and manage medicine.It is connected to electronic counter and the nut motion of motor Distribution can be controlled.Portable injection equipment may also include Reverse Turning Control part to reset equipment, to receive new cylinder and permit Perhaps equipment is used for multiple injection.Equipment can be additionally used in using opposite feature come filling tube.
Medication injection device may also include the hand injection feature for allowing hand injection medicine.Hand injection feature may include Slidingtype hand injection button, counter wheel and manual actuation gear.Hand injection button can be slid along the track to cause manual actuation Gear rotates.Manual actuation gear is a part for gear assembly and is attached to motorized motions gear so that manual actuation tooth The rotation of wheel causes motorized motions gear to rotate.
In another embodiment, portable medication injection device may include be used for receive cartridge case, gear assembly, motor, Driving screw, manually boot actuator, rotatable hand injection knob (knob), user interface, processor, power supply, one or more The chamber of individual sensor, ratchet (pawl) and communication module.Motor is engageable to gear assembly.Gear assembly may include to be attached to The motorized motions gear of motor and the helical gear (screw gear) for being attached to driving screw.Motorized motions gear is alternative Ground engages helical gear.Driving screw may be coupled to the nut including axle and piston coupling member, piston coupling member be configured to The piston component connection of cartridge case.Nut may include piston coupling mechanism to engage the piston of bottle.The startup of motor can make electronic drive Moving gear rotates.When motorized motions gear engages with helical gear, the rotation of motorized motions gear can cause helical gear to revolve Turn, so as to cause nut lengthwise movement.The lengthwise movement of nut can shift piston, so as to cause medicine to distribute or inhaled from cylinder Enter in cylinder.
Medication injection device may also include the hand injection feature for allowing to disconnect motor and hand injection medicine.Hand injection Feature may include Manual drug distribution knob, counter wheel, manual mode start button and reset button.Manual mode start button Engagement and be able to can be allowed by making motorized motions gear be disconnected from helical gear to be disconnected with power driver (drive) Use manual distribution knob.Distribution knob may be coupled to helical gear manually, and rotatable to distribute medicine.Counter wheel can show Show the Board Lot for the medicine being distributed.Reset button can be engaged to reset counter wheel after injection.Reset button connects Conjunction can also be re-engaged power driver.Counter wheel can by gear train and Manual drive mechanism, manual mode start button and Reset button engages.Hand injection feature may also include ratchet, the ratchet manually operated period with distribution knob engage to prevent Spin-ended button rotates in the opposite direction.
Medication injection device, which may also include, to be configured to allow the communication module with one or more external device communications.Communication Module can be for example, by radio communication, Bluetooth communication (for example, BTLE) or cellular communication and external device communication.Drug injection is set It is standby to may be connected to personal electronic equipments, such as, smart phone, tablet PC or personal computer, or can be passed to server Transmission of data.Injection device can transmit information to patient or to caregiver.Injection device may be additionally configured to and such as analyte Other medical device communications of measuring apparatus.Analysis measurement equipment can be transmitted to be had with the time for injection event and medication amount The information of pass.Suitable analysis measurement equipment is for example that on December 18th, 2012 No. 8,333,716 U.S. of issue is special Profit, No. 8,333,717 United States Patent (USP) issued on December 18th, 2012, the in issue on October 23rd, 2012 the 8,292nd, No. 826 United States Patent (USP)s, on 2 24th, 2015 issue No. 8,961,432 United States Patent (USP), in disclosed in 4 days April in 2013 No. 2013/0085349 U.S. Patent Publication, in No. 2015/0205930 United States Patent (USP) public affairs disclosed in 23 days July in 2015 Open and the 14/371st, No. 401 U.S. Patent application being submitted on July 9th, 2014 in be described, each of which Content is incorporated herein by reference in their entirety.
Portable medication injection device may also include multiple sensors, related to portable medication injection device to determine Various states and condition.Portable medication injection device may include for the type for determining the medicine in insertion equipment (for example, not The insulin of same type) sensor.The code of the detectable vessel for accommodating medicine of equipment, such as bar code or RFID marks Label.Barcode scanner or RF readers can be used.Equipment may also include the time for determining injection generation and inject more The sensor of few medicine.Sensor may include the timer of the time occurred for determining injection.If user is attempted in short-term Interior injection medicine is multiple, then the information from timer can be used to notify the recent injection event of user for equipment.Electronic card Amount of the chi available for the medicine for determining to be injected.In one embodiment, the longitudinal direction fortune of the axle of the measurable nut of electronic caliper It is dynamic.Alternately, magnetic sensor can be used for sensing in gear (such as, drive gear, the helical gear or shown below of equipment Counting wheel gear) on magnet motion to determine the amount of medicine being injected.Magnetic sensor can be used for measurement nut The lengthwise movement of axle.The medicine that sensor may further determine that medication amount in inhaler and be stayed in after injection event in bottle Amount.
Portable medication injection device may include cartridge case.Cartridge case can be to be configured to engage portable medication injection device Discrete item.Cartridge case can be disposable.Cylinder may include to receive the separator for pin insertion into a patient.Cylinder may also include piston Component is to allow the piston movement with retroversion forward.Piston component can engage with the piston coupling member of nut.Nut can with In the side of the pin in drug injection to patient is driven up into piston component.In addition, pin can be inserted into drug source, and nut can Piston component is driven to suck medicine in cylinder in the opposite direction.
Fig. 1 shows to be configured for distributing the stereogram of the illustrative embodiments of the injection device 100 of medicine.Injection is set Standby 100 include housing 102, multifunctional button 110, display cover 112, electric injection button 114 and charging port 116.Injection Equipment includes anterior 105A, back (not shown), the first sidepiece 105C and the second sidepiece (not shown).Housing 102 includes positioning Cap 106 in the proximal end of injection device 100, be positioned at injection device 100 far-end cap 108 and be positioned at cap 106 Main body 104 between cap 108.
Fig. 1 shows release button 118A on the first sidepiece 105C of injection device 100, coupling with cap 106.Button 118A is configurable to allow discharges and removes cap 106 from main body 104.In some embodiments, cap 106 can be with injection device Corresponding release button connection on 100 the second sidepiece, to allow to discharge from main body 104 and remove cap 106.Release button 122A It is shown as with cap 108 coupling on the first sidepiece 105C of injection device 100.Button 122A is configurable to allow from main body 104 and released Put and remove cap 108.In some embodiments, cap 108 can be to the corresponding release button on the second sidepiece of injection device 100 Connection, to allow to discharge from main body 104 and remove cap 108.
Display cover 112 can be positioned on the anterior 105A of injection device 100.Display cover 112 can be transparent Or it is translucent, to allow observation to be positioned at the indicator screen 240 below display cover 112.Indicator screen 240 is configurable For to user's display data.Multifunctional button 110 is alternatively positioned on the anterior 105A of injection device 100.Lid 112 may include out Mouthful to allow close to the multifunctional button 110 that is positioned in.Multifunctional button 110 can be arranged to receive data from user A part for the user interface of input.For example, multifunctional button 110 is configurable to allow the amount for selecting medicine to be distributed.More work( Energy button 110 may include any user's input feature vector, including but not limited to button, roller and keypad.In some embodiments In, multifunctional button 110 includes central select button and the switch key feature of selection can be carried out on four orthogonal directions.
Injection button 114 can be positioned in main body 102 on the sidepiece 105C of injection device 100.Injection button 114 can match somebody with somebody It is set to operation electric injection mechanism.In some embodiments, injection button 114 can be configured to operate electric injection mechanism to hold Row injection event, for example, distributing medicine from injection device 100 or being sucked from external source by medicine in injection device 100.Injection Button 114 may be additionally configured to operate electric injection mechanism so that medicine is sucked in injection device 100 from external source.In some implementations In mode, injection button 114 is configured to cause to carry out specific injection event in response to pressing and discharging injection button 114. In some embodiments, injection button 114 is configured to cause to carry out spy in response to injection button 114 is maintained at into depressed position Determine injection event.Although describing injection button 114, however, it will be appreciated that the imitation (imitation) of injection event is not limited to Button, but using such as switch, dial (dial), control-rod (lever), touch screen interface or any other input Equipment performs.
Charging port 116 can be positioned in main body 104 on the sidepiece 105C of injection device 100.Charging port 116 can match somebody with somebody It is set to and receives charging cable or connector, provides electric power to injection device 100 or the battery in injection device 100 is filled Electricity.Charging port 116 can be USB port, mini USB port, micro USB port or can receive charging cable it is any its His port.Charging port 116 can be configured to receive USB cable, mini USB cable, micro USB cable or can be set to electronics Standby any other charging cable for transmitting electric power.
Fig. 1 also illustrates a part and lid release button 126A for lid 124.Lid 124 prolongs in the upper back of injection device 100 Stretch, and the part on the sidepiece 105C with the main body 104 for being positioned at injection device 100.Lid release button 126A is being injected It is positioned on the sidepiece 105C of equipment 100 in main body 104, and is configurable to allow and lid is discharged and removed from injection device 100 124。
Fig. 2 shows the stereogram of the illustrative embodiments of injection device 100, shows the back of injection device 100 105B and sidepiece 105D.Fig. 2 shows the release button 118B coupled on the second sidepiece 105D of injection device 100 with cap 106. Button 118B is configurable to allow together with button 118A discharges and removes cap 106 from main body 104.Release button 122B is shown as Couple on second sidepiece 105D of injection device 100 with cap 108.Button 122B is configurable to allow together with button 122A from master Body 104 discharges and removed cap 108.Injection device 100 also includes side coupling and being positioned at injection device 100 with lid 124 Lid release button 126B on portion 105D.Lid release button 126B is configurable to allow from main body together with lid release button 126A 104 releases and removal lid 124.The medicine bottle for the inside for being configured to allow observation to be contained in injection device 100 is located in lid 124 Opening 130.Main body 104 also includes being configured to receive and the recess 128 of fixed labels.Label may include that being contained in injection sets The type of standby interior medicine, for example, the type of insulin.
Fig. 3 shows to remove the stereogram of the illustrative embodiments of the injection device 100 of cap 106 and cap 108.From main body 104 distal end protrudes the pin 132 for being configured to that medicine is conveyed to patient.Pin 132 is positioned in pin shell 140, pin shell 140 and then connection It is connected to cartridge case.The slider 134 for being configured to be slided in groove 136 is protruded from the near-end of main body 104.Slider 134 is to allow to use Manually distribute a part for the hand injection mechanism of medicine from pin 132 in family.The arm 216 of ratchet (pawl) is shown as setting in injection Standby 100 outside extension.
Fig. 4 A show to be configured to store the embodiment of the cartridge case 138 of medicine.Cartridge case 138 includes pin 132, pin shell 140, master Body 158, lug (tab) 142, protuberance 144 and the piston group including piston insert 154 and piston seal (not shown) Part.Piston insert 154 includes the elongated portion 146 positioned at its proximal end.
Fig. 4 B show to illustrate the sectional view of the cylinder 138 for the drug cavity 152 for being configured to receive and storing medicine.Pin shell 140 are configured to be fixed to coupling part 156 in the far-end of main body 158.Coupling part 156 can have screw thread, and be configured to Engaged with the complementary threaded portion of pin shell 140.Separator 150 is positioned at the inside of the distal end of main body 158.Separator is configured to Receive the pin 132 through it and provide sealing around pin 132 so that medicine will not leak to after pin 132 is inserted The outside of cylinder 138.Piston seal 148 is in the proximally-located of separator 150 in the inside of chamber 148.Piston seal 148 it is near End includes being configured to receive and being fixedly engaged the receiving portion (receptacle) 160 of the distal end of piston insert 154.Elongated portion Direct (Immediately) for dividing 146 is distally the cylindrical bar part 194 with the diameter smaller than the length of elongated portion 146. Piston insert 154 includes the coupling part 196 positioned away from cylindrical bar part 194.Coupling part 196 is configured to and is configured to Piston seal 148 is fixedly engaged.The diameter of cylindrical bar part 194 is less than the length or circle of a part for coupling part 196 Girth.Both piston insert 154 and piston seal 148 can include flexible polymer.Piston seal 148 and/or work Sealing can be formed in the proximal end of drug cavity 152 by filling in insert 154, to prevent drug leakage to the near-end of drug cavity 152 Outside.
In an alternative embodiment, cylinder 138 can be configured to engage with the conduit or intubation used in transfusion pumping operation.Example Such as, the coupling part 156 of the far-end of main body 158 can be configured to be fixedly engaged the first end of conduit.Second end of conduit can Via connector be attached to for insert patient hypodermis in intubation.In some embodiments, usable insertion is set Standby will be intubated is inserted in the tissue of patient.In some embodiments, cylinder 138 can be configured to be attached to commercially available defeated Liquid device (infusion set), such asTransfusion device.
Fig. 5 shows to remove the rearview of the illustrative embodiments of the injection device 100 of cap 106, cap 108 and lid 124. Fig. 5 shows the cartridge case 138 being positioned in main body 104.When lid 124 is removed, cylinder 138 can be inserted into injection device 100 neutralize from Injection device 100 removes.
Fig. 6 show a part in main body 104 from the rear portion 105B of injection device 100 remove in the case of injection device 100 rearview, it illustrated therein is the intraware of injection device 100.Injection device 100 includes battery 162, motor 164, tooth Wheel assembly 166 and nut 168.
Nut 168 includes axle 170 and piston coupling member 172.Piston coupling member 172 includes groove 174.Groove 174 It is configured to receive the T-shaped part 146 of the elongated of piston insert 154.The bottom plate 190 of piston coupling member 172 limits groove 174 Feather edge.Fig. 7 shows the sectional view of injection device 100.As shown in fig. 7, driving screw 184 can be positioned on the inside of nut 168. The inside of nut 168 can have screw thread to be threadedly engaged with driving screw 184.
Reference picture 6 and Fig. 7, gear assembly 166 include manual actuation gear 176 and multiple motorized motions gears 180.Manually Drive gear 176 and motorized motions gear 180 are configured to allow both electric injection mechanism and hand injection mechanism.
Electric injection mechanism
Motorized motions gear 180 is attached to motor 164.The startup of motor 164 can cause motorized motions gear 180 to rotate. Motorized motions gear 180 is attached in the driving screw (not shown) in the axle 170 for being contained in nut 168.The rotation of electric gear 180 Turn driving screw can be caused to rotate.Screw thread on driving screw and being threadedly engaged on the inside of nut 168.The end surface of bottom plate 190 It is configured to the near-end of engaging piston seal 148.The engageable piston insert 154 of proximal interior surface of piston coupling member 172 Elongated portion 146 proximal end face.The rotation of driving screw can cause nut 168 towards the distal advancement of injection device 100, or Proximal retraction of the person towards injection device 100.Advancing for nut 168 can be in the near of piston seal 148 and/or insert 154 Applying power on end, so as to cause piston seal 148 and/or insert 154 in drug cavity 152 towards injection device 100 Distal advancement.Piston seal 148 can cause medicine stream in drug cavity 152 towards the distal advancement of injection device 100 Move the outside of pin 132.Cylinder 138 includes groove 182 to allow the observability of the amount of the medicine in chamber 152.In order to by medicine In thing Sucked medicine chamber 152, motor 164 can cause electric gear 180 opposite with the direction of rotation for distributing medicine Side rotates up, so as to cause the near-end of nut 168 towards injection device 100 longitudinally to retract.The proximal retraction of nut 168 can So that the distal surface of elongated portion 146 is applied a force to by the proximal end face of plate 190, so as to cause the He of elongated portion 146 Piston seal 148 advances in drug cavity 152 towards the near-end of injection device 100.Piston seal 148 is set towards injection Standby 100 near-end, which advances, can cause medicine to be inhaled into drug cavity 152.
In an alternative embodiment, injection device 100 can be configured to perform continuous transfusion.As described above, cylinder 138 can join Conduit is connected to, the conduit is connected to intubation insertion into a patient.Motor 164 can be activated as described above, with via slotting Pipe conveys medicine in duration (for example, a few houres or several days) from cylinder 138.
Cartridge case and its use
Fig. 8 A show the sectional view of injection device 100, show the cylinder 138 separated with injection device 100.Injection device 100 include being configured to the receiving portion 186 for receiving cylinder 138.Microswitch 188 is extended in recess 186.Bottom plate 190 includes big The opening 192 of U-shaped is caused, opening 192 is configured to and is configured to allow cylinder 138 being fixed to injection device 100.Opening 192 can match somebody with somebody It is set to the cylindrical bar part 194 for receiving insert 154 so that the elongated of insert 154 or T-shaped part 146 are located at piston connection In the groove 174 of component 172.
Fig. 8 B show the sectional view of injection device 100, and it illustrates the cylinder 138 being positioned in recess 186.Cylinder 138 shows Go out to be in the unlocked position.In unlocked position, the major axis of elongated portion 146 is positioned to the major axis rough alignment with opening 192, makes Obtaining elongated portion 146 can pass through distal direction of the opening 192 of cylinder 138 along injection device 100 to advance.
Fig. 8 C show the sectional view of injection device 100, and it illustrates the cylinder 138 being positioned in recess 186.Cylinder 138 is Through from about 45 ° of position rotate counterclockwise shown in Fig. 8 B to latched position.It is engaged miniature in latched position, protuberance 144 Switch 188.The rotation of cylinder 138 causes the rotation of elongated or T-shaped part 146 so that the major axis of elongated portion 146 no longer with opening 190 major axis alignment so that the distal movement of cylinder 138 and piston component in recess 186 is prevented from.In some embodiments In, injection device 100 is configured to not perform electric injection if microswitch 188 is not engaged.When in locking position, In order to remove cylinder 138, cylinder must be rotated in a clockwise direction so that elongated or the major axis of T-shaped part 146 and the length of opening 190 Axle aligns, to allow cylinder to be distally advanced by opening 190.Cylinder 138 causes protuberance 144 from turning clockwise for latched position Depart from microswitch 188.The disconnection of microswitch 188 may cause driving screw 184 to be retracted to preform injection position automatically, and therefore Nut 168 is caused to be retracted to preform injection position automatically, wherein, the near-end of driving screw 184 and nut 168 close to drug cavity 152 Positioning.In this case, because elongated or T-shaped part 146 align with the major axis of opening 190, so the retraction of driving screw 184 Also the retraction of piston component will not be caused, it is stayed and be recessed in barrel chamber room.This feature prevents user after cylinder is removed Reuse.In some embodiments, unless microswitch 188 disconnects, otherwise driving screw 184 and therefore nut 168 It is configured to nonreversible.
In some embodiments, the processor in injection device 100 is programmed for based on one from microswitch 188 Or multiple readings, after cartridge case 138 inserts injection device 100, it is allowed to which predefined sequence of events occurs for cartridge case 138. After protuberance 144 engages microswitch 188, processor can allow the first event, in first event, piston seal 148 and piston insert 154 towards injection device 100 distal advancement, so as to which air is distributed into external drug from cartridge case 138 In the drug cavity in source.Then, processor can allow second event, in the second event, piston seal 148 and insert 154 towards injection device 100 proximal retraction, so as to by medicine Sucked medicine chamber 152.Processor can also allow for the 3rd Event, in the 3rd event, piston seal 148 and piston insert 154 towards injection device 100 distal advancement, with Just medicine is distributed.Processor is configurable to prevent that other things occur before protuberance 144 and microswitch 188 disconnect Part.In some embodiments, once injection device disconnects, piston insert 154 is aligned with opening 192, and nut 168 are retracted so that insert 154 and piston seal 148 are maintained in the base section of drug cavity 152.A series of this step Suddenly can play a part of preventing from reusing single cartridge case.The reuse of cartridge case may result in safety problem, such as broken Damage or reduction cylinder, medicine are mixed with the residue of previous injection, polluted.
Hand injection mechanism
With reference to figure 6 and Fig. 7, manual actuation gear 176 is attached to gear shaft 178 by roller clutch.Gear shaft 178 It is connected to slider 134.The movement of slider 134 can cause the rotation of gear shaft 178.Slider 134 is further attached to spring 198, bullet Spring 198 is configured to make slider 134 be back to original position after slider 134 is discharged.The rotation of gear shaft 178 can cause manually The rotation of drive gear 176.Manual actuation gear 176 is also coupled to multiple motorized motions gears 180.Manual actuation gear 176 Rotation can cause the rotation of motorized motions gear 180.The rotation of motorized motions gear 180 can cause medicine such as on electronic note Penetrate as described in mechanism and be distributed.
Fig. 9 A show the Local map of injection device 100, and it illustrates the slider mechanism for hand injection.Sliding equipment bag Include slider 134, rack 200, track 202, little gear 204, counter wheel 206, counter wheel opening 208, spring 218, the and of spring 198 Ratchet 214.In figure 9 a, slider 134 is illustrated at original position.Slider 134 is attached to rack 200.Rack 200 is configured to Slided when slider 134 advances from its original position towards counter wheel 206 along track 202.Rack 200 is in face of little gear Include multiple teeth on 204 outer surface.Multiple teeth of rack 200 are configured to and the complementary indented joint on the outside of little gear 204.It is small Gear 204 engages with the axle 170 (as shown in Figure 6) of injection device 100.When in original position, the tooth of rack 200 not with it is small Gear 204 engages.The advance of slider 134 causes rack 200 to advance along track 202.Advance of the rack 200 along track 202 causes The indented joint little gear 204 of rack 200.Being advanced further for rack 200 causes little gear 204 to rotate, and thus causes axle 170 to revolve Turn.As it was previously stated, the rotation of axle 170 can cause the rotation of manual actuation gear 176, and it therefore can cause injection event.Spring 198 are configured to make slider 134 be back to original position after slider 134 is discharged.
Counter wheel 206 includes multiple teeth 212.The top surface of counter wheel 206 includes multiple numerals, every in multiple teeth 212 Individual tooth has a numeral.Counter wheel opening 208 is configured to put forward the numeral being positioned on the counter wheel 206 below opening 208 For observability.Slider 134 can couple with arm 210.When slider 134 advances, arm 210 is configured to engage counter wheel 206 Tooth 212.
Fig. 9 B show the upward view of Fig. 9 A slider mechanism.Injection device 100 also includes ratchet 214.Ratchet 214 configures To engage multiple teeth 212 of counter wheel 206.Tooth 206 can be at an angle of so that ratchet 214 prevents counter wheel 206 along side counterclockwise To rotation, but allow the rotation along clockwise direction of counter wheel 206.The turning clockwise of counter wheel 206 can be configured to The repeated actuation of slider 134, there is provided the numeral increased continuously in opening 208 to occur.
Fig. 9 C show the slider mechanism for Fig. 9 A that slider 134 advances along track 202.Fig. 9 C are shown due to slider An arm 210 engaged in 134 preceding and then multiple teeth 212 with counter wheel 206.Slider 134 enters along track 202 One step, which is advanced, can cause being advanced further and rotate due to arm 210 of counter wheel 206.Fig. 9 D are shown in shown in Fig. 9 C The upward view of the slider mechanism of position.
In an exemplary embodiment of the present invention embodiment, slider 134 can advance from original position along the length of track 202, To distribute medicine increment.As it was previously stated, the advance of slider 134 causes the rotation of little gear 204, the rotation of little gear 204 Turn the distribution for causing medicine by gear assembly 166 and driving screw 184.It is multiple that the advance of slider 134 also causes arm 210 to engage One in tooth 212 so that the advance of arm 210 causes turning clockwise for counter wheel 206.Slider 134 is along track 202 The advance of length can cause counter wheel 206 to rotate so that ratchet 214 is bonded on before slider 134 advances and engaged by counter wheel 206 Next tooth 212 for positioning counterclockwise of an initial tooth 212.This rotation of counter wheel 206 causes can in opening 208 Numeral one unit of increase on the counter wheel 206 seen.According to illustrative embodiments, slider 134 is from original position along rail The advance of the length in road causes the medicine of one increment of distribution and makes one unit of visible numeral increase in opening 208, from And provide the counting of the quantity increment of the medicine of distribution.
Ratchet 214 includes pawl arm 216.Pawl arm 216 is configured so as to be applied to along the center position of injection device 100 Power in pawl arm 216 causes ratchet 214 to be disengaged from the tooth 212 of counter wheel 206.When counter wheel 206 departs from from ratchet 214 During engagement, torsionspring 220 causes counter wheel 206 to be back to initial position, in initial position, passes through 208 visible number of opening Word is zero.Arm 216 is connected to spring 218, and spring 218 makes center-biased of the arm 216 away from injection device 100 so that when power not Apply to biasing arm 216 during arm 216 so that ratchet 214 engages the tooth 212 of counter wheel 206.Cap 106 is placed on main body 104 Near-end on can cause arm 216 towards injection device 100 center advance, cause the release of the tooth 212 of counter wheel 206.Moving During except cap 106 for hand injection, this allows ratchet 214 to engage counter wheel 206, and after hand injection, when the weight of cap 106 New definition is when on the near-end of main body 104, it is allowed to which ratchet 214 is disengaged with counter wheel 206 and will be visible by opening 208 Numeral resets to zero.
Discharge device filling mechanism
Figure 10 shows the vertical of the illustrative embodiments for the injection device 100 for being bonded to pedestal 222 and fill tool 224 Body figure.Retainer 222 may include the recess 226 for being configured to receive the near-end of injection device 100.Retainer 222 can also include Widened section 228, the widened section 228 are configured to be placed flat on so that when injection device 100 is located at retainer When in 222, the major axis of injection device 100 is approximately perpendicular to flat surfaces.Fill tool 224 may be configured to be positioned at note Adapter member 230 above the distal end of jet device 100.Fill tool 224 also includes the cylinder for being configured to receive outside medicine bottle Body passage 232.In some embodiments, injection device 100 can be used for cartridge case 138 of the filling with medicine.The He of retainer 222 Fill tool 224 can be used for assisting padding.In order to fill the cartridge case 138 with medicine, the pin of cartridge case 138 can will be attached to In the outside medicine bottle of 132 insertions.In some embodiments using fill tool 224, fill tool 224 is first placed in injection In equipment 100.Medicine bottle is inserted in passage 232 so that pin 132 pierces through separator or plug in outside medicine bottle, outer to enter Drug cavity in portion's medicine bottle.Commercially available medicine bottle (such as storing the medicine bottle of insulin) be 3 milliliters, 10 milliliters and 20 milliliters of size.The shape and size of fill tool are configurable to accommodate 3 milliliters, 10 milliliters and/or 20 milliliters medicine bottles, or Any other conventional vial size.After syringe needle 132 is positioned in the drug cavity of outside medicine bottle, motor drive mechanism can use In making distal advancement of the piston seal 148 towards injection device 100 so that the motion of piston seal causes air from medicine Chamber 152 escapes and enter outside medicine bottle.In some embodiments, fill tool 224 is configured to fully fix outside medicine Bottle so that outside medicine bottle is in response to receiving the air from the discharge of drug cavity 152 without being disengaged with pin.Fill tool 224 It may include one or more connection elements, one or more connection elements are configured to one or more parts with outside medicine bottle Engage and it is fixed.For example, fill tool 224 may include the one or more for being configured to engage the lip of outside medicine bottle Ridges.Ridges can be being inserted with the outside medicine bottle of permission in fill tool 224 for taper, but limitation is outer at least in part Portion's medicine bottle leaves the motion of fill tool 224.One or more connection elements can be positioned at adapter member 230 and/or cylinder The inside of body passage 232.Next, motor drive mechanism can be operated in a reverse operation, to cause nut 168 towards injection The near-end of equipment 100 advances.The advance of nut 168 towards the near-end of injection device 100 will be close in piston insert 154 and piston Applying power on sealing 148, cause piston insert 154 and piston seal 148 away from pin 132 and towards injection device 100 Proximal retraction.Retraction of the piston seal 148 away from pin 132 can cause pin to draw liquid from the drug cavity of outside medicine bottle and inhale Into drug cavity 152.In some embodiments, can start entirely to fill by the single depression of injection button 114 Sequence.
Discharge device electronics
Figure 11 shows the schematic diagram of the illustrative embodiments of injection device 100.Injection device 100 includes processor 234th, user interface 236, communication module 238, battery 162, motor 164, memory 242, microswitch 188 and one or more Sensor 250.
User interface 236 can include injection button 114, multifunctional button 110 and indicator screen 240.It is multi-functional to press Button 110 can be configured to receive the selection of the various operating parameters for injection device 100 via communication module 238, in display The selection of the data shown on screen 240 and/or the data to external equipment or instruction.Via the user of multifunctional button 110 Interface 236 can be configured to receive the selection of medication amount to be distributed or receive the selection of the medication amount of suction cartridge case 138.User Interface 236 can be also used for the previous drugs distribution for selecting the external equipment of data to be sent, access to be stored in memory 242 Information and/or patient data, the alarm clock for setting distribution medicine, input patient data, input drug data, and/or confirmation come from Inject the instruction set, such as the instruction in special time injection medicine.User interface 236 can be configured to show time, battery shape State, wireless communication state, previous drugs distribution data time, the medication amount in cylinder 238 and one in recommended dose or It is multiple.It can be configured to receive the input from user via the user interface of injection button 114, to start to fill cartridge case 138 Or the electronic distribution medicine from cartridge case 138.
User interface 236 is also configured as the selection for the time span for receiving dosage and delivering the dosage.This can permit Perhaps injection device 100 works in the embodiment that cylinder 238 is attached to conduit in a manner of similar to infusion pump.In some realities To apply in mode, user interface can be configured to receive the selection of accumulated dose, receive the selection of the time span using accumulated dose, and The certain amount of discrete doses in accumulated dose are received, to be applied during the time span of accumulated dose is applied.
Processor 234 can be with user interface 236, battery 162, communication module 238, motor 164, memory 242, miniature Switch the communication of one or more of 188 and sensor 250.Processor 234 can be configured to by communication module 238 receive come From user interface 236 or the data from external equipment.Based on the data from user interface 236 or external equipment reception, processing Device can adjust one or more operating parameters of injection device 100 (for example, distribution or the medicine being drawn in cartridge case 138 Amount), start motor 164 to drive the distribution of medicine or by medicament extraction into cartridge case 138, prompt user in user interface 236 Upper input selection, the data storage in memory 242, and/or access data from memory 242.Conduit is attached in cartridge case 238 Embodiment in, based on from user interface 236 or external equipment reception data, processor be also configured as adjustment distribution Medication amount and distribution medicine time quantum.Processor is configurable to one or more in the whole time quantum of distribution medicine The individual moment starts motor, to distribute medicine by conduit.Processor is also configured as determining the speed for distributing medicine by conduit Rate and/or the one or more time intervals for distributing medicine by conduit, so as in the time quantum of the whole programming of distribution medicine Interior distribution medicine.
Processor 234 may also receive from the data of microswitch 188, include the engagement and disconnection of microswitch 188. The disconnection of engagement or microswitch 188 in response to microswitch 188, processor 234 are configurable to allow or prevent one Or the generation of multiple injection events.In some embodiments, processor is configurable to retrieve data from memory 242, will Transmitted from memory 242, user interface 236 and/or the data of microswitch 188 via communication module 238 to external equipment, And/or show the data from memory 242, user interface 236 and/or microswitch 188 via user interface 236.Processing Device 234 is also configured as receiving data from sensor 250.Based on the data received from sensor 250, processor can adjust One or more operating parameters of injection device 100, start motor 164 to perform injection event, prompt user in user interface Selection is inputted on 236, the data storage in memory 242, data is accessed from memory 242, number is shown on user interface 236 According to, or via communication module 238 send data to external equipment.
Battery 162 is configured to provide electric power to injection device 100.Battery 162 can be to processor 234, user interface 236th, communication module 238, motor 164, memory 242 and microswitch 188 provide electric power.Battery 162 can include any Electric power source.Battery 162 can be for example rechargeable by charging port 116.
According to illustrative embodiments, motor 164 can be stepper motor.However, motor 164 may include that tooth can be operated Any electric induction motor of wheel assembly 166.
Communication module 238 is configured to send data to one or more external equipments and/or set outside one or more It is standby to receive data.Communication module 238 be configurable to for example, by radio communication, Bluetooth communication (BTLE) or cellular communication with External equipment is communicated.Communication module 238 can be connected to individual's electricity of such as smart mobile phone, tablet personal computer or PC Sub- equipment, or server can be sent data to.Communication module 238 information can be communicated to user, doctor, pharmacy, Supplier, material supplier or any other related side.Injection device 100 is also configured as via communication module 238 and its He communicates at Medical Devices (for example, analysis measurement equipment).Injection device 100 can be received with being used for from analysis measurement equipment The medication amount of injection event and the information of time correlation.Injection device 100 is configurable to and as health management system arranged portion The one or more external device communications divided.The example of such system is the 2015/th disclosed in 23 days July in 2015 Enter in No. 0205930 U.S. Patent Publication and No. 14/371,401 U.S. Patent application submitted on July 9th, 2014 Description is gone, wherein each content is incorporated herein by reference in their entirety.Communication module 238 can include transmitter, receive One or more of device and transceiver.
In the exemplary embodiment, analyte monitoring equipment can have wireless connection and can be communicated to data High in the clouds.Analyte monitoring equipment can send data to and inject relevant medication injection device 100, such as the injection of recommendation Amount or time.Analyte monitoring equipment can also transmit measurement, user input data and the analysis measurement material with analyte The relevant data of the supply inventories (such as lancet or blood sugar test paper in blood glucose meter) of material.The data can by user, doctor, Pharmacy, supplier and/or material supplier monitor.Alternately, data can be automatically transmitted to user, doctor, pharmacy, Supplier and/or material supplier.Data can be uploaded automatically by analyte monitoring equipment.Such as computer, server, data The other equipments such as storehouse, personal electronic equipments or scale can be connected to high in the clouds, and can be with analyte monitoring equipment and/or medicine Thing injection device communicates.
Sensor 250 is configurable to determine the various states and condition related to injection device 100.One or more passes Sensor 250 can include one or more in electronic caliper, magnetic sensor, timer, barcode scanner or RF readers It is individual.Injection device 100 can include being used for the sensor 250 for determining the drug type in insertion equipment, such as determining not Same insulin-type.Sensor 250 can detect the code on the container for accommodating medicine, such as bar code or RFID label tag. Barcode scanner or RF readers can be used.Sensor 250 can also include being used for the time for determining that injection event occurs And the sensor for the medication amount being related in injection event.Sensor 250 can include being used to determine that the injection event time occurs Timer.If user attempts to start within a very short time injection repeatedly, injection device 100 can be used from timer Information notifies the nearest injection event of user.The medication amount of injection can be determined using electronic caliper.In an embodiment In, electronic caliper can measure the motion of the axle 170 of longitudinal nut 168.Alternatively, can be set using magnetic sensor to sense Magnet on standby gear motion (for example, one or more of manual actuation gear 176, motorized motions gear 180 or Person counts wheel gear), to determine the medication amount of injection.Magnetic sensor can also be used to measure the longitudinal direction of the axle 170 of nut 168 Motion.Sensor 250 may further determine that the medication amount sucked in cylinder 138 and the medicine remained in after injection event in cylinder 138 Amount.Sensor is configurable to sensor data transmission to processor 234.In response to sensing data, processor 234 can be with Sensing data is stored in memory 242, via communication module 238 by sensor data transmission to external equipment, will be passed Sensor data are shown on user interface 236 or changed the operation setting of injection device 100.
Injection device 100 can also include one or more indicators, to provide a user notice or alarm.For example, refer to Show device be configurable to alert user start the time of injection event, injection event end, injection medication amount, on may The warning of duplicate injection, and/or the reception of data from external equipment.Indicator can include sight indicator, audible Indicator and tactile indicators.Sight indicator can include one or more lamps, such as LED.It can be seen that instruction can also be presented On user interface 236.Audible indicator can include one or more loudspeakers.Tactile indicators can include being bonded to weight The motor of thing, to provide vibration.Warning time can be programmed in medication injection device 100.Alternatively, alarm can be from example External equipment such as analyte monitoring equipment transmits, and can be at least partially based on by the number of analyte testing device measuring According to.
In some embodiments, there is provided indicate to indicate the completion of injection.The instruction that injection is completed can include audible Instruction, such as beeping sound, chirp or jingle bell sound.The instruction that injection is completed can also include the haptic indication of such as vibration. In some embodiments, visible instruction, such as the flicker of light can be included for injecting the instruction completed.
In certain embodiments, there is provided indicate to alert the injection that user performs recently.If made via processor 234 It is determined that such as determine user just attempting to start subsequent injections after the injection performed recently, then such instruction can be provided. The instruction of the injection performed recently can include audible instruction, such as beeping sound, chirp or jingle bell sound.The note performed recently The instruction penetrated can also include the haptic indication of such as vibration.In some embodiments, the instruction of the injection performed recently can To include the flicker of visible instruction, such as light.
Distribute the discharge device of actuator manually with knob
Figure 12 shows the intraware of the replacement injection device 300 according to exemplary embodiment of the invention.Injection is set Standby 300 may include the feature similar to injection device 100.Injection device 300 includes main body 304, the medicine being positioned in main body 304 It is cylinder 338, driving screw 384, nut 368, piston component 348, motor 364, gear assembly 366, power module 362, rotatable Distribution knob 334, manual actuation of button 410, counting wheel gear 404, gear shaft 378 and SR 418 manually.
Motor 364 can be with engage gear component 366.Gear assembly 366 includes motorized motions gear 380 and screw drive tooth Wheel 372.Screw drive gear 372 could be attached to driving screw 384.Driving screw 384 could be attached to nut 368.Nut 368 can To be attached to piston component 348.The rotation of screw drive gear 372 may cause to the rotation of driving screw 384.Driving screw 384 Rotation may cause to lengthwise movement of the nut 368 on the distal direction of injection device 300, and this can cause the court of piston component 348 Displacement to the distal end of injection device 300.The displacement of piston component 348 towards the distal end of injection device 300 may cause to from cylinder Distribute medicine.Distribution can be controlled by moving the electronic counter associated with the movement of motor 364 and nut 368.Injection device 300 is also Reverse Turning Control can be included, to reset injection device 300 to receive new cylinder, and allow injection device 300 to be used for multiple injection. Injection device 300 can be also used for carrying out filling tube 338 using opposite feature, wherein screw drive gear 372 with for from cylinder The direction in opposite direction of 338 distribution medicines rotates.Injection device 300 is configured to allow both electric injection and hand injection.
Electric injection mechanism
Figure 12, which is shown, to be configured to be in injection device 300 in the configuration for the operation of electric injection mechanism.Figure 12 shows The motorized motions gear 380 of screw drive gear 372 is gone out to be bonded to.Motor 364 is bonded to gear assembly 366 so that motor 364 driving can cause the rotation of motorized motions gear 380.When the button on startup portable medication injection device, trigger Or during other actuating mechanisms, motor 364 can be started and manage medicine.When motorized motions gear 380 is bonded to screw drive gear When 372, the rotation of motorized motions gear 380 can cause the rotation of screw drive gear 372.As it was previously stated, screw drive gear 372 rotation may cause to distribute medicine or filling tube 338 from cylinder 338.Manual actuation of button 410 extends injection device 300 Main body 304 near-end.
Hand injection mechanism
Manual actuation of button 410 can be distally advanced into the main body 304 of injection device 300, so that motorized motions tooth Wheel 380 is distally advanced so that motorized motions gear 380 is disengaged with screw drive gear 372.Manual actuation of button 410 It is also coupled to platform 409.Count wheel gear 404 and be attached to platform 411, and platform 411 is positioned at least partially at platform 409 Proximal end face top on, platform 409 prevents platform 411 towards the distal advancement of injection device 100.Manual actuation of button 410 advance can also cause platform 409 towards the distal advancement of injection device 100, it is allowed to which platform 411 is towards injection device 100 Distal advancement.When counter wheel is positioned in injection device 300, the advance of platform 411 towards the distal end of injection device 100 causes Counting wheel gear 404 is set to be moved to the second place from first position, wherein, count wheel gear 404 in first position and do not couple To counter wheel, count wheel gear 404 in the second place and be connected to counter wheel.In some embodiments, when motorized motions gear 380 when being bonded to screw drive gear 372, can prevent the rotation for distributing knob 334.If motorized motions gear 380 is from spiral shell Bar drive gear 372 is disengaged, then the rotation for distributing knob 334 is configurable to cause to be attached to distribution knob 334 and tooth The distribution knob gear 407 of wheel shaft 378 rotates, and this may cause to the rotation of gear shaft 378.The advance of manual actuation of button 410 Ratchet 405 can also be caused to engage knob gear 407 so that only allow to distribute the rotation of knob 334 in a single direction.Gear The rotation of axle 378 may cause to count the rotation of wheel gear 404 and screw drive gear 372.As described above, screw drive gear 372 rotation may cause to distribute medicine from cylinder 338 or suck medicine in cylinder 338.Counting wheel gear 404 can be connected to Counter wheel (not shown).The rotation for counting wheel gear 404 may cause to the rotation of counter wheel.Reset button 418 can be used for weight Put one or more of counter wheel and button 410.Reset button 418 is attached to ratchet 405.When motorized motions gear 380 with When screw drive gear 372 engages, ratchet 405 is disengaged from distribution knob gear 407.When ratchet 405 and knob gear 407 During engagement, ratchet 405 is also configured as only allowing to count the rotation of wheel gear in one direction.Correspondingly, ratchet 405 from Distribution knob gear 407 is disengaged and counter wheel can be allowed to be reset.
Figure 13 shows the intraware of injection device 300 according to an illustrative embodiment of the invention, it illustrates It is configured so that the injection device 300 of hand injection mechanism.Motorized motions gear 380 is disengaged from screw drive gear 372. Figure 13 also show the ratchet 405 being disengaged from distribution knob gear 407.
Figure 14 shows the intraware of injection device 300 according to an illustrative embodiment of the invention, it illustrates The counter wheel 406 being positioned in injection device 300.
Figure 15 shows the counter wheel 406 according to exemplary embodiment of the invention.Counter wheel includes bracket 416, gear 408th, gear 412, gear 414 and numbered edges 413.Bracket 416 is configured to counter wheel being fixed to injection device 300.Gear 408, which are configured to engagement, counts wheel gear 404 so that counting the rotation of wheel gear 404 causes the rotation of gear 408.Gear 408 It is connected to gear 412 so that the rotation of gear 408 causes the rotation of gear 412.Gear 412 engages with gear 414 so that gear 414 rotation causes the rotation of gear 412.Gear 414 engages the inner surface of numbered edges 413 so that the rotation of gear 414 causes Make the rotation of numbered edges 413.Numbered edges 413 include multiple serial numbers throughout the outer surface of numbered edges 413 so that The rotation of numbered edges 413 allows serial number to pass through the visible viewing area of user.Numbered edges 413 are configurable to this The speed rotation of sample, the speed make it that visible numeral corresponds to the medication amount distributed from medication injection device in viewing area. Gear 414 can be with loading spring so that counting being disengaged for wheel gear 404 causes counter wheel to be back to original position, at this Original position, the visible numeral in viewing area is zero.
Embodiments disclosed herein provides the system for medical injector device, method and apparatus.Art technology Personnel are it will be recognized that these embodiments can be realized with hardware, software, firmware or its any combinations.
Functions described herein can be used as one or more instructions to be stored in processor readable medium or computer-readable On medium.Term " computer-readable medium " refers to any usable medium that can be accessed by computer or processor.As non-limit Property example processed, such medium can include RAM, ROM, EEPROM, flash memories, CD-ROM or other disk storages, Magnetic disk storage or other magnetic storage apparatus, or can be used for the storage desired program generation in the form of instruction or data structure Code and any other medium that can be accessed by computer.Magnetic plate and dish used herein includes CD (CD), laser disk, light Dish, digital versatile disc (DVD), floppy disk and Blu-ray Disc (Blu-Disc), wherein disk generally magnetically replicates number According to, and dish utilizes laser optics ground replicate data.It should be noted that computer-readable medium can be tangible and nonvolatile Property.Term " computer program product " refer to combine can by computing device or computing device, processing or calculating code or Instruct the computing device or processor of (for example, " program ").As it is used herein, term " code " can refer to by computing device Or software, instruction, code or the data of computing device.
Software or instruction can also pass through some transmission medium.If for example, use coaxial cable, fiber optic cables, multiple twin Line, Digital Subscriber Line (DSL) or such as wireless technology of infrared ray, radio and microwave are from website, server or other are long-range Source transmitting software, then coaxial cable, fiber optic cables, twisted-pair feeder, DSL or such as wireless technology of infrared ray, radio and microwave It is included in the definition of transmission medium.
Method disclosed herein includes being used for one or more steps or the action for realizing described method.Without departing substantially from power In the case of the scope that profit requires, method and step and/or action can exchange each other.In other words, unless described method The step of appropriate operation needs particular order or action, otherwise in the case of the scope without departing substantially from claim, can be changed The order and/or use of specific steps and/or action.
It should be noted that term as used herein " connection (couple) ", " connection (coupling) ", " connection (coupled) " or word connection other variants can indicate to be indirectly connected with or be directly connected to.If for example, first assembly " connection Connect " to the second component, then first assembly can be indirectly connected to the second component or be connected directly to the second component.As made herein , term " multiple " represents two or more.For example, multiple components indicate two or more components.
Term " it is determined that " cover various actions, and therefore " it is determined that " calculating, computing can be included, handle, push away Lead, investigate, searching (for example, being searched in form, database or another data structure), finding out.In addition, " it is determined that " can wrap Include reception (for example, receive information), access (for example, accessing the data in memory) etc..In addition, " it is determined that " solution can be included Analysis, selection, decision, foundation etc..
Unless otherwise expressly provided, otherwise phrase " being based on " is not meant to " being based only upon ".In other words, phrase " being based on " is retouched State both " being based only upon " and " being at least based on ".
In description above, concrete details is given to provide the thorough understanding to example.However, this area is common Technical staff, which will be understood that, to put into practice these examples in the case of these no details.For example, electronics group Part/equipment can be shown with block diagram, in order to avoid these examples of unnecessary unnecessary details.In other cases, can be shown specifically These components, other structures and technology are to be explained further example.
Headings included herein is used to refer to, and helps to position various pieces.These titles are not intended to limit for it The scope of described concept.These concepts can have applicability throughout the specification.
It is also noted that example can be used as process description, the process with flow chart, flow chart, finite state digraph, Structure chart or block diagram are shown.Although flow chart may be described the operations as sequential process, many operations can parallel or together Shi Zhihang, and process can repeat.In addition, the order of operation can rearrange.When the operation of process is completed, process is whole Only.Process can correspond to method, function, program, subroutine, subprogram etc..When the corresponding software function of a process, It is terminated is back to call function or principal function corresponding to the function.
The above description of disclosed embodiment is provided, so that any person skilled in the art can implement or use this Invention.To those skilled in the art, the various modifications to these embodiments will be apparent, and not carry on the back In the case of from the spirit and scope of the present invention, the General Principle limited herein can be applied to other embodiment.Therefore, originally Invention is not intended to be limited to embodiment shown in this article, but should be endowed consistent with principle disclosed herein and novel feature Widest range.

Claims (41)

1. a kind of medicine discharge device, including：
Recess, it is configured to receive removable cartridge case；
Gear assembly；
First sliding component, the gear assembly is attached to, and including cartridge piston coupling member, wherein the gear assembly Rotation be configured to cause the first sliding component lengthwise movement in the recess；
Motor, the gear assembly is attached to, wherein the startup of the motor is configured to cause the gear assembly to rotate.
2. medicine discharge device as claimed in claim 1, wherein, first sliding component includes female threaded shaft, and institute State the elongated screw member that medicine discharge device also includes being threadedly engaged with the female threaded shaft, the elongated screw member connection To the gear assembly so that the rotation of the gear assembly causes the elongated screw member to rotate, so as to cause described the One sliding component lengthwise movement.
3. medicine discharge device as claimed in claim 1 or 2, wherein, the cartridge piston coupling member includes being configured to connect Receive cartridge piston component T-shaped part groove.
4. medicine discharge device as claimed in claim 3, wherein, the groove is configured to allow the cartridge piston component T-shaped part between locked and unlocked positions in the groove internal rotation, wherein, when in the locked position, institute Stating the retraction of the first sliding component makes the cartridge piston component retract, and when in the unlocked position, described first Sliding component is disengaged from the cartridge piston component, and the retraction of first sliding component does not make the cartridge piston Component is retracted.
5. the medicine discharge device as any one of Claims 1-4, including with bonding station and disengaged position Manual distribution actuator, wherein, when in the bonding station, the motor not start in the case of, the hand The motion of dynamic distribution actuator causes the gear assembly to rotate；And when in the disengaged position, it is described manual Distribution actuator is not attached to the gear assembly.
6. medicine discharge device as claimed in claim 5, wherein, the actuator of distribution manually is in the disengaged position Middle biasing.
7. the medicine discharge device as described in claim 5 or 6, wherein, the actuator of distribution manually can not operated The bonding station is moved in the case of any other actuator.
8. the medicine discharge device as any one of claim 5 to 7, wherein, the actuator of distribution manually includes the Two sliding components.
9. medicine discharge device as claimed in claim 8, wherein, the first position of second sliding component is the disengaging Bonding station, and wherein described second sliding component are configured to slide into the second place as the bonding station, and The further slip of wherein described second sliding component causes the gear assembly to rotate.
10. the medicine discharge device as any one of claim 5 to 9, including rotatable counter wheel and counter wheel opening, Wherein, multiple numberings are carved with above the rotatable counter wheel, the counter wheel opening is configured to provide in the multiple numbering The observability of one.
11. medicine discharge device as claimed in claim 10, wherein, the counter wheel is attached to the distribution actuating manually Device；The actuating of the actuator of distribution manually causes one or more discontinuous medication amounts to be distributed and cause the counting Wheel rotation so that visible numbering refers to distributed one or more discontinuous medication amounts in the counter wheel opening Numbering.
12. the medicine discharge device as any one of claim 5 to 11, wherein, the gear assembly includes driving manually Moving gear and one or more motorized motions gears, the manual actuation gear are attached to one in the motorized motions gear It is individual, wherein, when in the bonding station, the motion of the actuator of distribution manually causes the manual actuation gear to revolve Turn, wherein, the rotation of the manual actuation gear causes the motorized motions gear to rotate, wherein, the motorized motions gear Rotation cause the first sliding component lengthwise movement.
13. the medicine discharge device as any one of claim 1 to 12, wherein, the motor is configured to make the tooth Wheel assembly rotates in forward direction and opposite direction, wherein rotation of the gear assembly in the forward direction causes institute State the first sliding component to proceed in the recess, and the rotation of the gear assembly in said opposite direction causes institute State the outside that the first sliding component is retracted to the recess.
14. medicine discharge device as claimed in claim 13, wherein, rotation of the gear assembly in the forward direction The access end of the cartridge piston component towards the cartridge case is caused to advance, wherein point of the piston component towards the cartridge case The advance of originator causes the fluid between the cartridge piston component and the access end of the cartridge case to be distributed from the cartridge case, The rotation of wherein described gear assembly in said opposite direction causes the distribution of the cartridge piston component away from the cartridge case End is retracted, wherein the retraction of the access end of the cartridge piston component away from the cartridge case causes the access end of the cartridge case to flow Body is sucked in the cartridge case.
15. the medicine discharge device as any one of claim 1 to 14, in addition to：
User interface, the user interface include being configured to the display data related to distributing the medicine from the medication device Display, wherein the user interface is additionally configured to receive selection of the user to medication amount；And
Processor, it is configured to receive data from the user interface, wherein the processor is configured to indicate the motor driving The gear assembly.
16. the medicine discharge device as any one of claim 1 to 15, in addition to power supply.
17. the medicine discharge device as any one of claim 1 to 16, in addition to be configured to measure first slip One or more sensors of the length travel of component.
18. medicine discharge device as claimed in claim 17, wherein, one or more of sensors include electronic caliper, One or more of magnetic sensor, timer, barcode scanner or RF readers.
19. the medicine discharge device as any one of claim 1 to 18, in addition to communication module, wherein the communication Module is configured to outside equipment transmission data.
20. medicine discharge device as claimed in claim 19, wherein the external equipment is analyte monitoring equipment.
21. the medicine discharge device as any one of claim 15 to 19, wherein the user interface is configured to show In medication amount and recommended dose in time, battery status, wireless communication state, the time of previous drugs distribution data, bottle It is one or more.
22. the medicine discharge device as any one of claim 1 to 21, in addition to：
One or more sensors, it is configured to detect position of the cartridge case in the recess；
One or more sensors, it is configured to detect injection event；And
Processor, it is configured to limit the number for the injection event being able to carry out when the cartridge case is in injection position.
23. the medicine discharge device as any one of claim 15 to 22, wherein, in response to detecting that the cartridge case is remote Moved from injection position, the processor is configured to make first sliding component to retract, wherein first sliding component from The cartridge piston component is disengaged, and the cartridge piston component is retracted.
24. the medicine discharge device as any one of claim 1 to 23, in addition to it is removable in the recess Except cartridge case, the removable cartridge case includes：
Chamber, it is configured to medicament storage in the cavity；
Piston component, it is positioned in the chamber, is configured to vertically move in the chamber, wherein the piston component couples To the cartridge piston coupling member；And
Separator, it is configured to receive pin.
25. medicine discharge device as claimed in claim 24, wherein the piston component includes piston seal and piston is inserted Enter part, wherein the piston insert is attached to the cartridge piston coupling member.
26. medicine discharge device as claimed in claim 25, wherein the piston insert includes being attached to the cartridge case work Fill in the T-shaped part of coupling member.
27. the medicine discharge device as any one of claim 24 to 26, wherein the removable cartridge case is included from institute The lug that the outer wall of removable cartridge case extends is stated, wherein the lug is configured to allow the removable cartridge case described recessed Portion's internal rotation, wherein rotation of the removable cartridge case in the recess allows the removable cartridge case to be slided with described first Dynamic component connection and disconnection connection.
28. the medicine discharge device as any one of claim 1 to 27, in addition to extend at least partly into described recessed The switch entered in portion, existence of the switchgear distribution for the detection cartridge case in the recess.
29. the medicine discharge device as any one of claim 1 to 27, in addition to electronic distribution actuator, wherein institute Electronic distribution actuator is stated to be configured to activate the motor in the case where applying external pressure to the electronic distribution actuator.
30. a kind of external member, including：
Medicine discharge device as any one of claim 1 to 29；And
Medicine fill tool, wherein the medicine fill tool includes：
Adapter member, it is configured to be attached to the end of the medicine discharge device；
Hollow circular cylinder, the adapter member is attached to, and is configured to receive medicine bottle, wherein the shape of the fill tool It is arranged so that position of the medicine bottle in the hollow circuit cylinder body makes in the medicine bottle and the recess and the recess Any cartridge case alignment.
31. the method for operating the medicine discharge device as any one of claim 1 to 23, including：
Cartridge case is inserted in the recess, the cartridge case includes：
Chamber, it is configured to medicament storage in the cavity；
Piston component, it is positioned in the chamber, is configured to vertically move in the chamber；And
Separator, in the end of the chamber；
One end of needle assemblies is inserted in the separator；
The opposite end insertion of the needle assemblies is accommodated in the medicine bottle of medicine；And
Medicine is sucked in the chamber of the cartridge case from the medicine bottle by the needle assemblies；
Medicine is distributed from the cartridge case by the pin.
32. method as claimed in claim 31, in addition to：Start the motor, with perform from the medicine bottle draw medicine and From one or more of cartridge case distribution medicine.
33. the method as described in claim 31 or 32, also using user interface, treat the medicine drawn from the medicine bottle Measure and treat to be programmed from one or more of medication amount of cartridge case distribution.
34. the method as any one of claim 31 to 33, in addition to detect and inject via one or more sensors The generation of event.
35. the method as any one of claim 31 to 34, in addition to the display data on user interface.
36. the method as any one of claim 31 to 35, in addition to outside equipment transmission data.
37. the method as any one of claim 31 to 36, in addition to：
The cartridge case is positioned in injection position, wherein the medicine discharge device is arranged so that if the cartridge case does not have Injection event is then prevented in the injection position；
Existence of the cartridge case in the injection position is detected via one or more sensors；
The generation of one or more injection events is detected via one or more sensors；And
Limit the number for the injection event that can occur when the cartridge case is in the injection position.
38. the method as any one of claim 31 to 37, in addition to：
The piston component of the cartridge case is coupled with the piston coupling member of the medicine discharge device, wherein distribution medicine includes The piston component is set to advance in the inside of the cartridge case, wherein the piston component is advanced includes setting the medicine distribution Standby piston coupling member advances；And
The cartridge case is set to be moved to the outside of the injection position, wherein being moved to the injection position in response to the cartridge case Outside, the piston coupling member disconnects from the piston component to be coupled, and in the feelings for not making the piston component retract Retracted automatically under condition.
39. for the cartridge case used in the medicine discharge device as any one of claim 1 to 23, the cartridge case bag Include：
Chamber, it is configured to medicament storage in the cavity；
Piston component, it is positioned in the chamber, is configured to vertically move in the chamber, wherein the piston component includes Piston seal and piston insert, wherein the piston insert is configured to couple structure with the cartridge piston of medicine discharge device Part couples；
Lug, extend from the outer wall of the cartridge case, wherein the lug is configured to allow the removable cartridge case in medicine to distribute The recess internal rotation of equipment, rotation of the removable cartridge case in the recess allow the removable cartridge case with it is described Cartridge piston coupling member couples and disconnected connection；
Ridges, extend from the outer wall of the cartridge case, wherein the ridges are positioned to allow for starting the medicine discharge device Inside switch；And
Separator, it is configured to receive pin.
40. the method for operating the medicine discharge device as any one of claim 1 to 23, including：
Cartridge case is inserted in the recess, the cartridge case includes：
Chamber, it is configured to medicament storage in the cavity；And
Piston component, it is positioned in the chamber, is configured to vertically move in the chamber；
Conduit is fixed to one end of the cartridge case；
Start the motor to distribute medicine from the cartridge case；And
Medicine is distributed from the cartridge case by the conduit.
41. method as claimed in claim 40, also using user interface, treat and divided by the conduit from the cartridge case One or more of the medication amount of hair and the time span of the distribution medication amount are programmed.
CN201680027691.1A 2015-03-13 2016-03-10 Portable medication injection device Pending CN107614036A (en)

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US201562133114P 2015-03-13 2015-03-13
US62/133,114 2015-03-13
PCT/US2016/021800 WO2016149038A1 (en) 2015-03-13 2016-03-10 Portable medicine injection device

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