CN107602436A - A kind of environment-friendly preparation method thereof of N substitutions L pyroglutamic acid esters - Google Patents
A kind of environment-friendly preparation method thereof of N substitutions L pyroglutamic acid esters Download PDFInfo
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- CN107602436A CN107602436A CN201710904167.4A CN201710904167A CN107602436A CN 107602436 A CN107602436 A CN 107602436A CN 201710904167 A CN201710904167 A CN 201710904167A CN 107602436 A CN107602436 A CN 107602436A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
The present invention provides a kind of environment-friendly preparation method thereof of N substitution L pyroglutamic acid esters (I), and with L glutamic acid (II) for initiation material, in the presence of acid reagent, L glutamic acid diesters hydrochloride (III) is prepared through esterification；Then above-mentioned L glutamic acid diesters hydrochloride (III) is in the presence of alkali and solvent; N substitution protection reactions occur through " one kettle way " and N substituents protection reagent and introduce N substitution protection groups, then heats intramolecular dealcoholysis cyclization and obtains N substitution L pyroglutamic acid esters (I).Raw material of the present invention is cheap and easy to get, and reaction type is classical, and process route is short, easy to operate, and wastewater flow rate is few, and production process is green, and reaction yield is high, and product cost is low.The N substitution L pyroglutamic acid esters (I) prepared using the present invention can prepare 5R benzyloxy amino piperidine 2S formic acid esters, 5R benzyloxy amino piperidine 2S formic acid ester oxalates and AVM hereinafter Batan.
Description
Technical field
The present invention relates to a kind of environment-friendly preparation method thereof of N- substitutions-L-Glutimic acid ester, belong to medicine bioengineering chemical field.
Background technology
N- substitutions-L-Glutimic acid ester (I) is a kind of important chemical industry, medicine intermediate, in field of medicaments, N- substitutions-
L-Glutimic acid ester can be used for preparing new extended spectrumβ-lactamase inhibitor AVM hereinafter Batan, patent CN103649051A,
CN105294690A, US20140275001 prepare AVM hereinafter Batan using N- substitutions-L-Glutimic acid ester (I).N- substitutions-L-
The structural formula of pyroglutamic acid ester (I) and AVM hereinafter Batan is as follows：
Existing N- substitutions-L-Glutimic acid ester (I) preparation method is and benzyl chloride, organic base, 1 using pyroglutamic acid as raw material,
2- dichloroethanes reacts (CN105732454A methods) or obtained with bromobenzyl, organic base, acetone reaction (CN105130870A methods)
To L-Glutimic acid ester, then protected to obtain N- substitutions-L-Glutimic acid ester.See reaction scheme 1.
Reaction scheme 1
Above method is raw material using the strong bromobenzyl of excitant or benzyl chloride, and the reaction time is grown, low production efficiency, wastewater flow rate
Greatly；Other pyroglutamic acid price is higher, and pyroglutamic acid needs to be prepared by (150-160 DEG C) melting of glutamic acid high temperature, and operation is not
Just, post-process cumbersome, it is necessary to repeatedly decolourize, a large amount of waste water of decolorization generation, yield only has 75%；And prepared by the above method
Journey needs three operating procedures, process route length, is unfavorable for green production.
The content of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of green preparation side of N- substitutions-L-Glutimic acid ester (I)
Method, raw material of the present invention is cheap and easy to get, and reaction type is classical, and process route is short, easy to operate, and wastewater flow rate is few, production process green
Environmental protection, reaction yield is high, and product cost is low.
Compound number and formula numbers in this specification is completely the same, and there is identical to refer to relation.
Technical scheme is as follows：
A kind of preparation method of N- substitutions-L-Glutimic acid ester, including step：
(1) with Pidolidone (II) for initial feed, in the presence of alcohol and acid reagent, L- paddy ammonia is prepared through esterification
Acid diesters hydrochloride (III)；
Wherein, the R in formula III is C1-6Saturated fat base or alkyl-substituted phenyl.
(2) the Pidolidone diester hydrochloride (III) that step (1) obtains is in the presence of alkali and solvent, with N- substituents
Protect reagent that N- substitution protection reactions occur and introduce N- substitution protection groups, N- substitutions-L-Glutimic acid ester is obtained through dealcoholysis cyclization
(I)；
Wherein, the R in Formulas I is identical with the R in formula III, and PG is t-butyloxycarbonyl, benzyloxycarbonyl, ethyl oxygen
One kind in base carbonyl, allyloxycarbonyl or phenyloxycarbonyl.
According to currently preferred, step (1) described alcohol is C1-6Saturated fatty alcohol, the substitution of fragrant and mellow or alkyl it is fragrant and mellow in
One kind.
Preferably, the alcohol be methanol, it is ethanol, normal propyl alcohol, isopropanol, n-butanol, isobutanol, the tert-butyl alcohol, n-amyl alcohol, different
Amylalcohol, tert-pentyl alcohol, hexanol, benzylalcohol, o-methyl benzyl alcohol or to one kind in xylyl alcohol；It is further preferred that the alcohol is benzyl
One kind in alcohol, ethanol, the tert-butyl alcohol or methanol.
According to currently preferred, the mass ratio of alcohol described in step (1) and Pidolidone (II) is 8-30:1.
According to currently preferred, acid reagent described in step (1) is one in thionyl chloride, triphosgene or surpalite
Kind.
Preferably, the mol ratio of the thionyl chloride and Pidolidone (II) is 2.0-10.0:1；The esterification temperature
Spend for 40-85 DEG C；It is further preferred that the esterification reaction temperature is 60-85 DEG C.Reaction time is 1-8 hours.
Preferably, the triphosgene and the mol ratio of Pidolidone (II) are 0.33-2.5:1；The esterification reaction temperature
For 50-100 DEG C；It is further preferred that the esterification reaction temperature is 60-80 DEG C.Reaction time is 1-8 hours.
Preferably, the surpalite and the mol ratio of Pidolidone (II) are 0.5-3.5:1；The esterification reaction temperature is
50-100℃；It is further preferred that the esterification reaction temperature is 60-80 DEG C.Reaction time is 1-8 hours.
According to currently preferred, the mol ratio of acid reagent described in step (1) and Pidolidone (II) is 0.33-
10.0:1。
According to currently preferred, esterification reaction temperature described in step (1) is 30-100 DEG C；Preferably, the esterification
Reaction temperature is 40-85 DEG C.
According to currently preferred, reaction time of esterification described in step (1) is 1-8 hours.
According to currently preferred, alkali described in step (2) is inorganic base or organic base；The inorganic base be potassium carbonate,
Sodium carbonate, calcium carbonate, saleratus, sodium acid carbonate, calcium bicarbonate, potassium acetate, sodium acetate, calcium acetate, sodium hydride, sodium methoxide,
Combination more than one or both of caustic alcohol, sodium tert-butoxide, potassium tert-butoxide or benzylalcohol sodium；The organic base be triethylamine,
Combination more than one or both of tri-n-butylamine, diisopropylethylamine or pyridine.
According to currently preferred, the mol ratio of alkali and Pidolidone diester hydrochloride (III) is described in step (2)
1.0-2.0:1。
According to currently preferred, solvent described in step (2) is 1,2- dichloroethanes, 1,1,2- trichloroethanes, tetrahydrochysene
Combination more than one or both of furans, 2- methyltetrahydrofurans, methoxy cyclopentane, benzene, toluene or dimethylbenzene.
According to currently preferred, the mass ratio of solvent and Pidolidone diester hydrochloride (III) is described in step (2)
4-20:1。
According to currently preferred, the protection reagent of N- substituents described in step (2) is two dimethyl dicarbonate butyl esters, chloromethane
One kind in acid benzyl ester, ethyl chloroformate, allyl chlorocarbonate, chloro-carbonic acid tertiary butyl ester or phenyl chloroformate.
According to currently preferred, the protection reagent of N- substituents described in step (2) and Pidolidone diester hydrochloride
(III) mol ratio is 1.0-2.0:1.
According to currently preferred, the substitution protection reaction temperatures of N- described in step (2) are -20-80 DEG C；Preferably, institute
It is 20-50 DEG C to state N- substitution protection reaction temperatures.
According to currently preferred, the substitution protection reaction time of N- described in step (2) is 2-10 hours.
According to currently preferred, dealcoholysis ring-closure reaction temperature described in step (2) is 60-120 DEG C；Preferably, it is described
Dealcoholysis ring-closure reaction temperature is 70-105 DEG C.
According to currently preferred, step (2) the dealcoholysis ring-closure reaction time is 2-8 hours.
The present invention is described as following reaction scheme (reaction scheme 2)：
Reaction scheme 2
The technical characterstic and beneficial effect of the present invention：
1st, the present invention in the presence of alcohol and acid reagent, is prepared with Pidolidone (II) for initial feed through esterification
Pidolidone diester hydrochloride (III)；Then N- substitution protections are introduced with N- substituents protection reagent reacting in the basic conditions
Base, heated intramolecular dealcoholysis cyclization, " one kettle way " obtain N- substitutions-L-Glutimic acid ester (I).
2nd, compared with prior art, the present invention is without using bromine Bian or benzyl chloride, non-hazardous, green；The present invention is with L- paddy
Propylhomoserin (II) is initial feed, and raw material is cheap and easy to get, and reaction type is classical, and process route is short, easy to operate, and product cost is low；
The present invention need not wash to product, and waste water yield is few, and the Organic Ingredients such as solvent for use can with recycling,
It is green, it can effectively reduce cost；And reaction yield is high, total recovery is up to 93.4%.
Embodiment
The present invention is described in detail with reference to embodiments, but the present invention is not only limited to this.
% in embodiment is mass percent, except having a special instruction.
Using gas phase or liquid chromatograph monitoring course of reaction and product purity, using equipped with chiral column (ES-OVS,
150mm × 4.6mm, Agilent company) liquid chromatograph detection optical purity (area is than %), and calculated yield and e.e%
Value.
Embodiment 1：Pidolidone dibenzyl ester hydrochloride (III1) preparation
To 500 millis equipped with stirring, thermometer and reflux condensing tube (30% sodium hydrate aqueous solution absorption plant of connection)
Rise and 280 grams of benzylalcohols are added in four-hole boiling flask, 14.7 grams of (0.10 mole) Pidolidones, 30.0 grams of (0.25 mole) thionyl chlorides,
Heating, 80~85 DEG C are reacted 5 hours, are cooled to 20~25 DEG C, the hydrogen chloride gas in nitrogen displacement system, are replaced 30 minutes
Afterwards, excessive thionyl chloride and benzylalcohol are distilled to recover, 120 grams of methyl tertiary butyl ethers are then added into residue, is beaten, filtering,
Dry, obtain 35.9 grams of white solid Pidolidone dibenzyl ester hydrochlorides, liquid phase purity 99.8%, yield 98.7%.
Embodiment 2：Pidolidone dibenzyl ester hydrochloride (III1) preparation
To 500 millis equipped with stirring, thermometer and reflux condensing tube (30% sodium hydrate aqueous solution absorption plant of connection)
Rise and 280 grams of benzylalcohols are added in four-hole boiling flask, 14.7 grams of (0.10 mole) Pidolidones, 30.0 grams of (0.15 mole) surpalites, add
Heat, 70~75 DEG C are reacted 6 hours, are cooled to 20~25 DEG C, the hydrogen chloride gas in nitrogen displacement system, after displacement 30 minutes.
Excessive surpalite and benzylalcohol are distilled to recover, 120 grams of methyl tertiary butyl ethers are then added into residue, is beaten, is filtered, is dried,
Obtain 35.5 grams of white solid Pidolidone dibenzyl ester hydrochlorides, liquid phase purity 99.7%, yield 97.6%.
Embodiment 3：Pidolidone diethyl ester hydrochloride (III2) preparation
To 500 millis equipped with stirring, thermometer and reflux condensing tube (30% sodium hydrate aqueous solution absorption plant of connection)
Rise and 300 grams of ethanol are added in four-hole boiling flask, 14.7 grams of (0.10 mole) Pidolidones, 25.0 grams of (0.08 mole) triphosgenes, add
Heat, 70~75 DEG C are reacted 5 hours, are cooled to 20~25 DEG C, the hydrogen chloride gas in nitrogen displacement system, after displacement 30 minutes.
Excessive triphosgene and ethanol are distilled to recover, 100 grams of methyl tertiary butyl ethers are then added into residue, is beaten, is filtered, is dried,
Obtain 23.5 grams of white solid Pidolidone diethyl ester hydrochlorides, liquid phase purity 99.7%, yield 98.0%.
Embodiment 4：Pidolidone diformazan ester hydrochloride (III3) preparation
To 500 millis equipped with stirring, thermometer and reflux condensing tube (30% sodium hydrate aqueous solution absorption plant of connection)
Rise and 300 grams of methanol are added in four-hole boiling flask, 14.7 grams of (0.10 mole) Pidolidones, 30.0 grams of (0.25 mole) thionyl chlorides,
Heating, 60~63 DEG C are reacted 7 hours, are cooled to 20~25 DEG C, the hydrogen chloride gas in nitrogen displacement system, are replaced 30 minutes
Afterwards, excessive thionyl chloride and methanol are distilled to recover, 100 grams of methyl tertiary butyl ethers are then added into residue, is beaten, filtering,
Dry, obtain 20.8 grams of white solid Pidolidone diformazan ester hydrochlorides, liquid phase purity 99.5%, yield 98.1%.
Embodiment 5：N- t-butyloxycarbonyls-L-Glutimic acid benzyl ester (I1) preparation
18.2 grams (0.05 moles) are added into 500 milliliters of four-hole boiling flasks equipped with stirring, thermometer and reflux condensing tube
Pidolidone dibenzyl ester hydrochloride prepared by embodiment 1,150 grams of toluene, 7.8 grams of (0.06 mole) diisopropylethylamine, 12.0
Gram (0.055 mole) two dimethyl dicarbonate butyl ester, heating, 30~35 DEG C are reacted 4 hours, and 90~95 DEG C are reacted 5 hours, are cooled to
20~25 DEG C, filtering, distillation filtrate recycling designs, 50 grams of methyl tertiary butyl ether recrystallizations are added into residue, filters, dries,
15.1 grams of white powder solid N- t-butyloxycarbonyls-L-Glutimic acid benzyl esters, liquid phase purity 99.9% are obtained, yield is
94.6%.
Products obtained therefrom nuclear magnetic data is as follows：1H-NMR (400MHz, CDCl3)δ：1.42 (9H, s), 2.01 (1H, m), 2.30
(1H, m), 2.49 (1H, m), 2.58 (1H, m), 4.63 (1H, t), 5.20 (2H, m), 7.36 (5H, m).
Embodiment 6：N- t-butyloxycarbonyls-L-Glutimic acid benzyl ester (I1) preparation
18.2 grams (0.05 moles) are added into 500 milliliters of four-hole boiling flasks equipped with stirring, thermometer and reflux condensing tube
Pidolidone dibenzyl ester hydrochloride prepared by embodiment 2,150 gram 1,1,2- trichloroethanes, 7.8 grams of (0.06 mole) diisopropyls
Ethamine, 8.2 grams of (0.06 mole) chloro-carbonic acid tertiary butyl esters, 25~30 DEG C are reacted 5 hours, and 80~85 DEG C are reacted 5 hours, are cooled to
20~25 DEG C, filtering, distillation filtrate recycling designs, 50 grams of methyl tertiary butyl ether recrystallizations are added into residue, filters, dries,
14.7 grams of white powder solid N- t-butyloxycarbonyls-L-Glutimic acid benzyl esters, liquid phase purity 99.8% are obtained, yield is
92.0%.
Embodiment 7：N- t-butyloxycarbonyls-ethyl L-pyroglutamate (I2) preparation
12.0 grams (0.05 moles) are added into 500 milliliters of four-hole boiling flasks equipped with stirring, thermometer and reflux condensing tube
Pidolidone diethyl ester hydrochloride prepared by embodiment 3,120 grams of 2- methyltetrahydrofurans, 8.5 grams of (0.06 mole) potassium carbonate,
8.2 grams of (0.06 mole) chloro-carbonic acid tertiary butyl esters, 25~30 DEG C are reacted 5 hours, and 75~80 DEG C are reacted 7 hours, it is cooled to 20~
25 DEG C, filtering, distillation filtrate recycling design, 40 grams of methyl tertiary butyl ether recrystallizations are added into residue, is filtered, is dried, obtain
11.5 grams of white powder solid N- t-butyloxycarbonyls-ethyl L-pyroglutamates, liquid phase purity 99.5%, yield are
89.3%.
Products obtained therefrom nuclear magnetic data is as follows：1H-NMR (400MHz, CDCl3)δ：1.21 (3H, t), 1.46 (9H, s), 2.02
(1H, m), 2.31 (1H, m), 2.48 (1H, m), 2.59 (1H, m), 4.16 (2H, q), 4.61 (1H, m).
Embodiment 8：N- benzyloxycarbonyls-L-Glutimic acid benzyl ester (I3) preparation
18.2 grams (0.05 moles) are added into 500 milliliters of four-hole boiling flasks equipped with stirring, thermometer and reflux condensing tube
Pidolidone dibenzyl ester hydrochloride prepared by embodiment 1,150 gram 1,1,2- trichloroethanes, 6.1 grams of (0.06 mole) triethylamines,
10.5 grams of (0.06 mole) benzyl chloroformates, 35~40 DEG C are reacted 4 hours, and 100~105 DEG C are reacted 3 hours, are cooled to 20~25
DEG C, filtering, distillation filtrate recycling design, 50 grams of methyl tertiary butyl ether recrystallizations are added into residue, is filtered, is dried, obtain
16.2 grams of white powder solid N- benzyloxycarbonyls-L-Glutimic acid benzyl esters, liquid phase purity 99.3%, yield 91.7%.
Products obtained therefrom nuclear magnetic data is as follows：1H-NMR (400MHz, CDCl3)δ：2.06 (1H, m), 2.34 (m, 1H), 2.50
(m, 1H), 2.61 (1H, m), 4.72 (1H, m), 5.12 (2H, s), 5.21 (s, 2H), 7.40-7.20 (m, 10H).
Comparative example 1：N- t-butyloxycarbonyls-L-Glutimic acid benzyl ester (I1) preparation
11.0 grams (0.03 moles) are added into 500 milliliters of four-hole boiling flasks equipped with stirring, thermometer and reflux condensing tube
Pidolidone dibenzyl ester hydrochloride prepared by embodiment 1,90 grams of toluene, 4.7 grams of (0.036 mole) diisopropylethylamine, 7.2 grams
(0.033 mole) two dimethyl dicarbonate butyl ester, heating, 30~35 DEG C are reacted 4 hours, and 50~55 DEG C are reacted 8 hours, are cooled to 20
~25 DEG C, filtering, distillation filtrate recycling design, 30 grams of methyl tertiary butyl ether recrystallizations are added into residue, is filtered, is dried, obtain
It is to 2.2 grams of white powder solid N- t-butyloxycarbonyls-L-Glutimic acid benzyl esters, liquid phase purity 99.1%, yield
23.0%.
From this comparative example, dealcoholysis ring-closure reaction temperature has a great influence to the yield of final product, dealcoholysis cyclization temperature
It is too low, the drastically decline of final product yield can be caused.
Claims (10)
1. a kind of preparation method of N- substitutions-L-Glutimic acid ester, including step：
(1) with Pidolidone (II) for initial feed, in the presence of alcohol and acid reagent, Pidolidone two is prepared through esterification
Ester hydrochloride (III)；
Wherein, the R in formula III is C1-6Saturated fat base or alkyl-substituted phenyl；
(2) the Pidolidone diester hydrochloride (III) that step (1) obtains is protected in the presence of alkali and solvent with N- substituents
Reagent occurs N- substitution protection reactions and introduces N- substitution protection groups, and N- substitutions-L-Glutimic acid ester (I) is obtained through dealcoholysis cyclization；
Wherein, the R in Formulas I is identical with the R in formula III, and PG is t-butyloxycarbonyl, benzyloxycarbonyl, ethyl epoxide carbonyl
One kind in base, allyloxycarbonyl or phenyloxycarbonyl.
2. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that step (1) is described
Alcohol is C1-6Saturated fatty alcohol, the substitution of fragrant and mellow or alkyl it is fragrant and mellow in one kind；
Preferably, the alcohol is methanol, ethanol, normal propyl alcohol, isopropanol, n-butanol, isobutanol, the tert-butyl alcohol, n-amyl alcohol, isoamyl
Alcohol, tert-pentyl alcohol, hexanol, benzylalcohol, o-methyl benzyl alcohol or to one kind in xylyl alcohol；It is further preferred that the alcohol be benzylalcohol,
One kind in ethanol, the tert-butyl alcohol or methanol；
Preferably, the mass ratio of alcohol described in step (1) and Pidolidone (II) is 8-30:1.
3. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (1)
Acid reagent is stated as one kind in thionyl chloride, triphosgene or surpalite；
Preferably, the mol ratio of the thionyl chloride and Pidolidone (II) is 2.0-10.0:1；The esterification reaction temperature is
40-85℃；It is further preferred that the esterification reaction temperature is 60-85 DEG C；
Preferably, the triphosgene and the mol ratio of Pidolidone (II) are 0.33-2.5:1；The esterification reaction temperature is 50-
100℃；It is further preferred that the esterification reaction temperature is 60-80 DEG C；
Preferably, the surpalite and the mol ratio of Pidolidone (II) are 0.5-3.5:1；The esterification reaction temperature is 50-
100℃；It is further preferred that the esterification reaction temperature is 60-80 DEG C.
4. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (1)
The mol ratio for stating acid reagent and Pidolidone (II) is 0.33-10.0:1.
5. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (1)
Esterification reaction temperature is stated as 30-100 DEG C；Preferably, the esterification reaction temperature is 40-85 DEG C.
6. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (2)
It is inorganic base or organic base to state alkali；The inorganic base is potassium carbonate, sodium carbonate, calcium carbonate, saleratus, sodium acid carbonate, carbonic acid
In hydrogen calcium, potassium acetate, sodium acetate, calcium acetate, sodium hydride, sodium methoxide, caustic alcohol, sodium tert-butoxide, potassium tert-butoxide or benzylalcohol sodium
One or more kinds of combinations；The organic base be triethylamine, tri-n-butylamine, diisopropylethylamine or pyridine in one kind or
Two or more combinations；
Preferably, the mol ratio of alkali described in step (2) and Pidolidone diester hydrochloride (III) is 1.0-2.0:1.
7. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (2)
State solvent for 1,2- dichloroethanes, 1,1,2- trichloroethanes, tetrahydrofuran, 2- methyltetrahydrofurans, methoxy cyclopentane, benzene,
Combination more than one or both of toluene or dimethylbenzene；
Preferably, the mass ratio of solvent described in step (2) and Pidolidone diester hydrochloride (III) is 4-20:1.
8. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (2)
It is two dimethyl dicarbonate butyl esters, benzyl chloroformate, ethyl chloroformate, allyl chlorocarbonate, chloromethane to state N- substituents protection reagent
One kind in sour tertiary butyl ester or phenyl chloroformate；
Preferably, the mol ratio of the protection reagent of N- substituents described in step (2) and Pidolidone diester hydrochloride (III) is
1.0-2.0:1。
9. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that institute in step (2)
It is -20-80 DEG C to state N- substitution protection reaction temperatures；Preferably, the N- substitutions protection reaction temperature is 20-50 DEG C.
10. the preparation method of N- substitutions-L-Glutimic acid ester according to claim 1, it is characterised in that in step (2)
The dealcoholysis ring-closure reaction temperature is 60-120 DEG C；Preferably, the dealcoholysis ring-closure reaction temperature is 70-105 DEG C.
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| PCT/CN2018/078071 WO2019062027A1 (en) | 2017-09-29 | 2018-03-06 | Green preparation method for n-substituted-l-pyroglutamic acid ester |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019062027A1 (en) * | 2017-09-29 | 2019-04-04 | 新发药业有限公司 | Green preparation method for n-substituted-l-pyroglutamic acid ester |
| CN113321606A (en) * | 2021-06-22 | 2021-08-31 | 吉尔生化（上海）有限公司 | Preparation method of (S) -1- (benzyloxycarbonyl) -5-oxopyrrolidine-2-formic acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104628622A (en) * | 2015-01-29 | 2015-05-20 | 上海应用技术学院 | Preparation method of saxagliptin intermediate |
| CN105229010A (en) * | 2013-01-29 | 2016-01-06 | 阿普廷伊克斯股份有限公司 | Spiral shell-lactan nmda receptor conditioning agent and uses thereof |
| CN105732454A (en) * | 2016-02-22 | 2016-07-06 | 济南诚汇双达化工有限公司 | Production technology of L-pyroglutamic acid benzyl ester |
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| CN102127063A (en) * | 2011-01-06 | 2011-07-20 | 深圳市普迈达科技有限公司 | New synthesis technology of anti-cancer drug Raltitrexed |
| EP3375773A1 (en) * | 2011-12-15 | 2018-09-19 | Dow Global Technologies Llc | Process for preparing alkyl pyroglutamic acids |
| CN102827058A (en) * | 2012-09-18 | 2012-12-19 | 江苏德峰药业有限公司 | Production method of N-t-butoxycarbonyl-L-pyroglutamate |
| CN107602436A (en) * | 2017-09-29 | 2018-01-19 | 新发药业有限公司 | A kind of environment-friendly preparation method thereof of N substitutions L pyroglutamic acid esters |
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| CN105229010A (en) * | 2013-01-29 | 2016-01-06 | 阿普廷伊克斯股份有限公司 | Spiral shell-lactan nmda receptor conditioning agent and uses thereof |
| CN104628622A (en) * | 2015-01-29 | 2015-05-20 | 上海应用技术学院 | Preparation method of saxagliptin intermediate |
| CN105732454A (en) * | 2016-02-22 | 2016-07-06 | 济南诚汇双达化工有限公司 | Production technology of L-pyroglutamic acid benzyl ester |
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| WO2019062027A1 (en) * | 2017-09-29 | 2019-04-04 | 新发药业有限公司 | Green preparation method for n-substituted-l-pyroglutamic acid ester |
| CN113321606A (en) * | 2021-06-22 | 2021-08-31 | 吉尔生化（上海）有限公司 | Preparation method of (S) -1- (benzyloxycarbonyl) -5-oxopyrrolidine-2-formic acid |
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