CN107582523A - A kind of Myrrha volatile oil nano-emulsion and preparation method thereof - Google Patents
A kind of Myrrha volatile oil nano-emulsion and preparation method thereof Download PDFInfo
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- CN107582523A CN107582523A CN201710830177.8A CN201710830177A CN107582523A CN 107582523 A CN107582523 A CN 107582523A CN 201710830177 A CN201710830177 A CN 201710830177A CN 107582523 A CN107582523 A CN 107582523A
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Abstract
The invention discloses a kind of Myrrha volatile oil nano-emulsion and preparation method thereof, represented with parts by weight, mainly by 30 ~ 50 parts of EL, 40,1 ~ 10 part of 1,2 propane diols, 1 ~ 10 part of Myrrha volatile oil, 1 ~ 5 part of PEG 400, enough distilled water compositions.Nano-emulsion caused by the present invention is oil-in-water type nano-emulsion, can use water infinite dilution.Under transmission electron microscope, nano-emulsion is rounded, and nothing is adhered.Average grain diameter（Z‑Average）For 12.3nm, polydispersity coefficient（PDI）For 0.207.At 25 DEG C, the average zeta current potentials of the Angelica grosseserrata volatile oil nano-emulsion after 5 times of dilution are（‑11.4±0.3）MV, it has good stability with thermostatic accelerated experiment result collectively show that；The nano-emulsion preparation technology is simple and quality controllable, and antiphlogistic effects are good, is expected to be applied to clinic.
Description
Technical field
The present invention relates to nano-emulsion preparation field, in particular to a kind of Myrrha volatile oil nano-emulsion and preparation method thereof.
Background technology
Nanoemulsions（nanoemulsion）Also known as microemulsion（microemulsion）, it is by water, oil, EL-40 and 1,2-
Propane diols etc. spontaneously forms, and particle diameter is 1~100nm Thermodynamically stable, isotropism, transparent or semitransparent homogeneous dispersion
Be in general, nano-emulsion is divided into three types, i.e. oil-in-water type nano-emulsion (O/W), water-in-oil type nanoemulsion (W/O and double
Continuous type nano-emulsion (B.C), nineteen forty-three are found and report this dispersion first by Hoar and Schulman.Until 1959
Year, Schulman just proposes " microemulsion " this concept.Hereafter, the theory of nano-emulsion and application study obtain fast
The development of speed.At present, nanometer emulsified technology has penetrated into daily-use chemical industry, fine chemistry industry, petrochemical industry, material science, biological skill
The field such as art and environmental science, turn into the current research field in the world with huge applications potentiality.
Nano-emulsion has the advantages of many other preparations are incomparable：1. being isotropic transparency liquid, belong to thermodynamics
Systems stabilisation, it can not be allowed to be layered through pressure sterilizing or centrifugation；2. technique is simple, preparation process is not required to special installation, can be certainly
Hair is formed, and nano-emulsion particle diameter is generally 1~100nm；3. viscosity is low, pain during injection can be reduced；4. with sustained release and targeting
Effect；5. improving the solubility of medicine, the enzymolysis of medicine in vivo is reduced, the protective effect to medicine can be formed and improve stomach and intestine
Absorption of the road to medicine, improve the bioavilability of medicine.Therefore nano-emulsion is widely paid close attention to as a kind of pharmaceutical carrier.
Myrrha volatile oil myrrh essential oil is known as " patron saint of reproductive organs ", can sterilize, and disinfection force is strong, can suppress skin
Inflammation, it is all effective in cure to pimples eczema.Dry and cracked and pernio skin can be moistened, it is also effective to wrinkle.Manufacture the basic essence of perfume
One of, people can be allowed to bask pleasant.Strengthen brain vigor, recover body and mind vigor, clear-minded head.But Myrrha volatile oil is molten
Xie Du and stability have been short of, in terms of clinical application is carried out, by very big restriction.
The content of the invention
It is an object of the invention to provide a kind of effective Myrrha volatile oil nano-emulsion for improving Myrrha volatile oil stability.
It is another object of the present invention to provide the preparation method of above-mentioned Myrrha volatile oil nano-emulsion.
The present invention is achieved through the following technical solutions：A kind of Myrrha volatile oil nano-emulsion, is represented with parts by weight, mainly by 30
~ 50 parts of EL-40,1 ~ 10 part of 1,2-PD, 1 ~ 10 part of Myrrha volatile oil, 1 ~ 5 part of PEG-400, enough distilled water compositions.
In order to which the present invention is better achieved, further, represented with parts by weight, the EL-40 is 32 parts, 1,2-PD
Be 7.5 parts for 3 parts, Myrrha volatile oil, PEG-400 be 1.5 parts, and distilled water be 57 parts.
A kind of preparation method of above-mentioned Myrrha volatile oil nano-emulsion, comprises the following steps：
（1）EL-40 is added in four-hole boiling flask, Myrrha volatile oil, EL-40, RH-40, stirring makes it well mixed；
（2）Four-hole boiling flask is fixed under water bath condition, water temperature is maintained at 40 ~ 60 DEG C, after raw material fully melts, starts stirring
Device, mixing speed are 150 ~ 200rpm；
（3）After material temperature in four-hole boiling flask up to after 40 ~ 60 DEG C, stop stirring, add PEG-400, continue to stir, continue
30min；
（4）Stop stirring, 40 ~ 60 DEG C of hot distilled waters are added dropwise with rubber head dropper, after 3 ~ 8h is added dropwise to complete, 1h is incubated in 40 ~ 60 DEG C；
（5）Heating water bath is closed, after being cooled to normal temperature, adds bactericide, continues to stir 30min；
（6）After 5 ~ 10 DEG C being cooled to using cold bath, filtering and discharging.
In order to which the preparation of nano-emulsion in the present invention is better achieved, further, the stirring used in the preparation process
Device is magnetic stirring apparatus.
In order to which the preparation of nano-emulsion in the present invention is better achieved, further, the step（4）In, thermal distillation is added dropwise
Water uses rubber head dropper.
In order to which the preparation of nano-emulsion in the present invention is better achieved, further, the step（4）In, thermal distillation is added dropwise
The process of water is that a drop is added dropwise in every 3 ~ 4min, per 2 ~ 3ml of dropper.
The present invention compared with prior art, has advantages below and beneficial effect：
（1）Nano-emulsion caused by the present invention is oil-in-water type nano-emulsion, can use water infinite dilution.Under transmission electron microscope, nano-emulsion is in circle
Spherical, nothing is adhered.Average grain diameter（Z-Average）For 12.3nm, polydispersity coefficient（PDI）For 0.207.At 25 DEG C, dilution 5
The average zeta current potentials of Angelica grosseserrata volatile oil nano-emulsion after times are（-11.4±0.3）MV, with the common table of thermostatic accelerated experiment result
Bright its has good stability；
（2）Nano-emulsion preparation technology of the present invention is simple and quality controllable, and antiphlogistic effects are good, is expected to be applied to clinic.
Embodiment
The present invention is described in further detail with reference to embodiment, but the implementation of the present invention is not limited to this,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, various replace is made
Change and change, all should be included within the scope of the invention.
Embodiment：
The Myrrha volatile oil nano-emulsion of the present embodiment, as mass fraction：w（Myrrha volatile oil）=7.5%, w（EL-40）=30%, w
（RH-40）=2%, w（PEG-400）=1.5%, w（Distilled water）=59%.
Its preparation method, comprise the following steps：
（1）EL-40 is added in four-hole boiling flask, Myrrha volatile oil, EL-40, RH-40, stirring makes it well mixed；
（2）Four-hole boiling flask is fixed under water bath condition, water temperature is maintained at 40 ~ 60 DEG C, after raw material fully melts, starts stirring
Device, mixing speed are 150 ~ 200rpm；
（3）After material temperature in four-hole boiling flask up to after 40 ~ 60 DEG C, stop stirring, add PEG-400, continue to stir, continue
30min；
（4）Stop stirring, 40 ~ 60 DEG C of hot distilled waters are added dropwise with rubber head dropper, after 3 ~ 8h is added dropwise to complete, 1h is incubated in 40 ~ 60 DEG C；
（5）Heating water bath is closed, after being cooled to normal temperature, adds bactericide, continues to stir 30min；
（6）After 5 ~ 10 DEG C being cooled to using cold bath, filtering and discharging.
The present embodiment screens prescription, and it is carried out using Myrrha volatile oil as reagent thing by drawing pseudo-ternary phase diagram
Quality evaluation.Differentiate the type of nano-emulsion with decoration method, form is investigated with transmission electron microscope, with Zetasizer Nano
ZS analyzers and photon correlation spectroscopy measure particle diameter and polydispersity coefficient, after by thermostatic accelerated experiment examine its stable
Property, its antiphlogistic effects is studied finally by the suppression experiment of mice caused by dimethylbenzene xylene auricle edema.Mice caused by dimethylbenzene xylene ear
The suppression result of the test of wide swelling is shown：Myrrha volatile oil has certain antiinflammatory action, and swelling inhibiting rate is better than ground up to 66%
Sai meter Song 58%, after nano-emulsion is made, swelling inhibiting rate is up to 89%.Myrrha volatile oil nano-emulsion preparation technology is simple and quality can
Control, antiphlogistic effects are good, are expected to be applied to clinic.
Embodiment 2：
It is equal further to limit the agitator used in the preparation process in order to preferably realize the preparation of nano-emulsion for the present embodiment
For magnetic stirring apparatus.The present embodiment other parts are same as the previously described embodiments, repeat no more here.
Embodiment 3：
The present embodiment further limits the step to preferably realize the preparation of nano-emulsion（4）In, hot distilled water, which is added dropwise, to be made
It is rubber head dropper.The present embodiment other parts are same as the previously described embodiments, repeat no more here.
Embodiment 4；
The present embodiment further limits the step to preferably realize the preparation of nano-emulsion（4）In, hot distilled water is added dropwise
Process is that a drop is added dropwise in every 3 ~ 4min, per 2 ~ 3ml of dropper.The present embodiment other parts are same as the previously described embodiments, here no longer
Repeat.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
A variety of change, modification, replacement and modification can be carried out to these embodiments by departing under the principle and objective of the present invention, of the invention
Scope is limited by claim and its equivalent.
Claims (6)
- A kind of 1. Myrrha volatile oil nano-emulsion, it is characterised in that：Represented with parts by weight, mainly by 30 ~ 50 parts of EL-40,1 ~ 10 part RH-40,1 ~ 10 part of Myrrha volatile oil, 1 ~ 5 part of PEG-400, enough distilled water compositions.
- A kind of 2. Myrrha volatile oil nano-emulsion according to claim 1, it is characterised in that：Represented with parts by weight, the EL- 40 be 30 parts, RH-40 is 2 parts, Myrrha volatile oil is 7.5 parts, PEG-400 is 1.5 parts, and distilled water is 59 parts.
- 3. the preparation method of a kind of Myrrha volatile oil nano-emulsion according to claim 1 or claim 2, it is characterised in that including following Step：（1）EL-40 is added in four-hole boiling flask, Myrrha volatile oil, EL-40, RH-40, stirring makes it well mixed；（2）Four-hole boiling flask is fixed under water bath condition, water temperature is maintained at 40 ~ 60 DEG C, after raw material fully melts, starts stirring Device, mixing speed are 150 ~ 200rpm；（3）After material temperature in four-hole boiling flask up to after 40 ~ 60 DEG C, stop stirring, add PEG-400, continue to stir, continue 30min；（4）Stop stirring, 40 ~ 60 DEG C of hot distilled waters are added dropwise with rubber head dropper, after 3 ~ 8h is added dropwise to complete, 1h is incubated in 40 ~ 60 DEG C；（5）Heating water bath is closed, after being cooled to normal temperature, adds bactericide, continues to stir 30min；（6）After 5 ~ 10 DEG C being cooled to using cold bath, filtering and discharging.
- A kind of 4. Myrrha volatile oil nano-emulsion according to claim 3, it is characterised in that：Used in the preparation process Agitator is magnetic stirring apparatus.
- A kind of 5. Myrrha volatile oil nano-emulsion according to claim 3 or 4, it is characterised in that：The step（4）In, drop Heating distilled water uses rubber head dropper.
- A kind of 6. Myrrha volatile oil nano-emulsion according to claim 5, it is characterised in that：The step（4）In, heat is added dropwise The process of distilled water is that a drop is added dropwise in every 3 ~ 4min, per 2 ~ 3ml of dropper.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327215A (en) * | 2011-09-25 | 2012-01-25 | 西北农林科技大学 | Medecamycin nanoemulsion antibacterial drug and preparation method thereof |
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- 2017-09-15 CN CN201710830177.8A patent/CN107582523A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327215A (en) * | 2011-09-25 | 2012-01-25 | 西北农林科技大学 | Medecamycin nanoemulsion antibacterial drug and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周莹: "没药挥发油纳米乳的制备及其抗炎效果研究", 《畜牧与兽医》 * |
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Application publication date: 20180116 |