CN107573689A - The preparation method of Simethicone - Google Patents
The preparation method of Simethicone Download PDFInfo
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- CN107573689A CN107573689A CN201710656955.6A CN201710656955A CN107573689A CN 107573689 A CN107573689 A CN 107573689A CN 201710656955 A CN201710656955 A CN 201710656955A CN 107573689 A CN107573689 A CN 107573689A
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- Prior art keywords
- simethicone
- dimeticone
- sio
- micronization processes
- preparation
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Abstract
The invention discloses a kind of preparation method of Simethicone, comprise the steps：1）Micronization processes, silica carry out micronization processes using airslide disintegrating mill, SiO 2 powder particle diameter is met D95≤10μm；2）Mixing, dimeticone is pumped into stainless steel electrical heating kettle, the SiO 2 powder added after micronization processes, and the mass ratio of dimeticone and SiO 2 powder is 16.8 ~ 17.5:1, the temperature in then stainless steel electrical heating kettle is increased to more than 140 DEG C, continues stirring and is no less than 2h, obtains Simethicone.The preparation method of Simethicone of the present invention, silica is subjected to micronization processes using airslide disintegrating mill first, is well mixed again with dimeticone after fine silica powderization processing, it is not easy to be layered, product stability is excellent；Secondly it is excellent using rational reaction temperature and reaction time, the defoaming effect of obtained product.
Description
Technical field
The present invention relates to pharmaceutical synthesis field, more particularly to a kind of preparation method of Simethicone.
Background technology
Simethicone（simethicone emulsion）, chemical name be α-（Trimethyl silicane methyl）- w- methyl gathers
【Oxygen（Dimethyl Asia silylene group）】With silica composite.Simethicone is the uniform emulsion of canescence, slightly banana flavor.West
First silicone oil is a kind of surfactant of stabilization, i.e. dimethyl silicone polymer, can change and be present in chyme and mucus in alimentary canal
The surface tension of interior bubble, and be allowed to decompose, the gas discharged can be absorbed by intestinal wall or be discharged by enterocinesia.It is domestic normal
Alone dimeticone or silica act on weaker as defoamer；Both share, defoaming effect enhancing, diformazan silicon
Oily 9.4mg, silica 0.6mg, the effect of 1000mg dimeticones can be reached.As answering for dimeticone and silica
Compound, the pharmacological action of Simethicone outclass dimeticone or silica.Simethicone belongs to pharmacology and physiology is lazy
Property material, the sub-acute toxicity test of rat show that Simethicone is free of toxic effects.
The content of the invention
The present invention solves the technical problem of a kind of preparation method of Simethicone is provided, can produce to obtain stabilization
Not stratified Simethicone.
In order to solve the above technical problems, one aspect of the present invention is：
A kind of preparation method of Simethicone is provided, comprised the steps：
1）Micronization processes, silica carry out micronization processes using airslide disintegrating mill, meet SiO 2 powder particle diameter
D95≤10μm；
2）Mixing, dimeticone is pumped into stainless steel electrical heating kettle, the SiO 2 powder added after micronization processes,
The mass ratio of dimeticone and SiO 2 powder is 16.8 ~ 17.5:1, the temperature in then stainless steel electrical heating kettle is increased to
More than 140 DEG C, continue stirring and be no less than 2h, obtain Simethicone.
In a preferred embodiment of the present invention, the viscosity of the dimeticone is 600 ~ 1000mPas.
In a preferred embodiment of the present invention, in step 2）In, the temperature in stainless steel electrical heating kettle is increased to 140
~ 180 DEG C, then it is stirred mixing.
The beneficial effects of the invention are as follows：The preparation method of Simethicone of the present invention, silica is used into air-flow powder first
Broken machine carries out micronization processes, is well mixed again with dimeticone after fine silica powderization processing, it is not easy to it is layered,
Product stability is excellent；Secondly it is excellent using rational reaction temperature and reaction time, the defoaming effect of obtained product.
Brief description of the drawings
Fig. 1 is the preparation flow schematic diagram of a preferred embodiment of the present invention.
Embodiment
Presently preferred embodiments of the present invention is described in detail below in conjunction with the accompanying drawings, so that advantages and features of the invention energy
It is easier to be readily appreciated by one skilled in the art, apparent is clearly defined so as to be made to protection scope of the present invention.
The present invention chemical reaction process be：
Embodiment 1：
The technological process of production of the present invention is as shown in figure 1, its step specifically includes：
1）Micronization processes, silica carry out micronization processes using airslide disintegrating mill, meet SiO 2 powder particle diameter
D95≤10μm；
2）Mixing, 47kg dimeticone is pumped into stainless steel electrical heating kettle, the viscosity of dimeticone is 600 ~ 1000mPa
S, adds SiO 2 powders of the 2.7kg after micronization processes, and the temperature in then stainless steel electrical heating kettle raises 140 DEG C
More than, continue to stir more than 2h, obtain Simethicone.The viscosity of Simethicone product is 700 ~ 1400mPas.
Embodiment 2：
Production stage is 47kg with embodiment 1, the wherein dosage of dimeticone, and the SiO 2 powder after micronization processes is
2.7kg, the temperature in stainless steel electrical heating kettle are increased to more than 140 DEG C.
Embodiment 3：
Production stage is 47kg with embodiment 1, the wherein dosage of dimeticone, and the SiO 2 powder after micronization processes is
2.7kg, the temperature in stainless steel electrical heating kettle are increased to more than 140 DEG C.
Comparative example：
Foam liquid weighs 5g docusate sodiums and is dissolved in 1000mL distilled water.
Defoaming liquid takes Simethicone test sample 250mg, is dissolved in 50ml butanone, is heated to being no more than 50 DEG C, shaking.
100ml foam liquids are added in the 250ml tool plug reagent bottles that internal diameter is about 5cm by determination method, are added 1ml and are disappeared
Steep liquid（Simethicone）, acutely shaking 60 seconds, stand and start timing, Part I non-foam liquid level occur and stop timing, disappear
Steeping the time should be no more than 15 seconds.Test data see the table below.
In upper table, sample 3 is using the product of any preparation in embodiment 1 ~ 3 as sample, and remaining sample is then using real
The raw material and proportioning of one of example 1 ~ 3 are applied, but reaction temperature therein does respective change with the reaction time according to upper table.
The above results are visible, and when temperature is less than 140 DEG C, reaction is incomplete, and lamination occurs in product appearance.Temperature is
At 140 DEG C and 180 DEG C, uniform translucent liquid can be obtained.Principle in view of reducing energy consumption, selection are more than
140 DEG C are optimal reaction temperature.Under the conditions of 140 DEG C, when reacted between when being less than 2h, product not exclusively may be caused due to complexing
It is undesirable to defoam power；When reaction time is more than 2h, defoaming power do not dramatically increase, therefore, select 2h for optimum response when
Between.Finally by above-mentioned experimental data, it is more than 140 DEG C to determine optimal reaction temperature, and the time is no less than 2h.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalent structure or equivalent flow conversion that bright specification and accompanying drawing content are made, or directly or indirectly it is used in other related skills
Art field, is included within the scope of the present invention.
Claims (3)
1. a kind of preparation method of Simethicone, it is characterised in that comprise the steps：
1）Micronization processes, silica carry out micronization processes using airslide disintegrating mill, meet SiO 2 powder particle diameter
D95≤10μm；
2）Mixing, dimeticone is pumped into stainless steel electrical heating kettle, the SiO 2 powder added after micronization processes,
The mass ratio of dimeticone and SiO 2 powder is 16.8 ~ 17.5:1, the temperature in then stainless steel electrical heating kettle is increased to
More than 140 DEG C, continue stirring and be no less than 2h, obtain Simethicone.
2. the preparation method of Simethicone according to claim 1, it is characterised in that the viscosity of the dimeticone is
600~1000mPa·s。
3. the preparation method of Simethicone according to claim 1, it is characterised in that in step 2）In, by stainless steel electricity
Temperature in heating kettle is increased to 140 ~ 180 DEG C, then is stirred mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710656955.6A CN107573689A (en) | 2017-08-03 | 2017-08-03 | The preparation method of Simethicone |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710656955.6A CN107573689A (en) | 2017-08-03 | 2017-08-03 | The preparation method of Simethicone |
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| CN107573689A true CN107573689A (en) | 2018-01-12 |
Family
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| CN201710656955.6A Pending CN107573689A (en) | 2017-08-03 | 2017-08-03 | The preparation method of Simethicone |
Country Status (1)
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0891776A1 (en) * | 1997-07-17 | 1999-01-20 | McNEIL-PPC, INC. | Simethicone/anhydrous calcium phosphate compositions |
| CN102532901A (en) * | 2010-12-21 | 2012-07-04 | 重庆北碚现代应用药物研究所 | Method for preparing simethicone |
| CN104610745A (en) * | 2015-01-13 | 2015-05-13 | 山东大学 | Preparation method for simethicone |
-
2017
- 2017-08-03 CN CN201710656955.6A patent/CN107573689A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0891776A1 (en) * | 1997-07-17 | 1999-01-20 | McNEIL-PPC, INC. | Simethicone/anhydrous calcium phosphate compositions |
| CN102532901A (en) * | 2010-12-21 | 2012-07-04 | 重庆北碚现代应用药物研究所 | Method for preparing simethicone |
| CN104610745A (en) * | 2015-01-13 | 2015-05-13 | 山东大学 | Preparation method for simethicone |
Non-Patent Citations (1)
| Title |
|---|
| LJERKA BREČEVIĆ，等: "Mechanism of antifoaming action of simethicone", 《JOURNAL OF APPLIED TOXICOLOGY》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180112 |
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| RJ01 | Rejection of invention patent application after publication |