CN107551319A - A kind of preparation method of anti-bone tumor composite bone reconstruction bracket - Google Patents
A kind of preparation method of anti-bone tumor composite bone reconstruction bracket Download PDFInfo
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- CN107551319A CN107551319A CN201710570380.6A CN201710570380A CN107551319A CN 107551319 A CN107551319 A CN 107551319A CN 201710570380 A CN201710570380 A CN 201710570380A CN 107551319 A CN107551319 A CN 107551319A
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- mass parts
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- phosphate
- reconstruction bracket
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Abstract
The invention discloses a kind of preparation method of anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：The mass parts of polyamide 20~30；Strontium compound is 20~25 mass parts；Hydroxyapatite is 15~20 mass parts；Calcium phosphate is 50~60 mass parts；Alkaline phosphatase is 5~10 mass parts；α tricalcium phosphates are 50~60 mass parts；Calcium monohydrogen phosphate is 50~60 mass parts；Disodium hydrogen phosphate is 20~30 mass parts；Sulfuric acid calcium powder is 20~30 mass parts；Hydrochloride is 5~10 mass parts；Calcium bicarbonate suspension is 10~20 mass parts；Phosphoric acid is 10~20 mass parts and collagen solution is 10~20 mass parts.The present invention has good amalgamation, after Composite Bone reconstruction bracket contacts with people's bone, on the one hand the bone of injury is fixed, prevents second hurt, on the other hand can supplement calcium ion to the bone of injury, promote bone growth rehabilitation.
Description
Technical field
The present invention relates to Composite Bone reconstruction bracket technical field, especially a kind of system of anti-bone tumor composite bone reconstruction bracket
Preparation Method.
Background technology
Bone tumour therapy is the complex treatment that collection is performed the operation, chemotherapy and radiation is combined, due to the guarantor of four limbs malignant bone tumor
Limb is treated, and backbone malignant bone tumor adjacent structure is complicated, and focus is difficult to thoroughly cut off, postoperative to prevent recurrence from just turning into increasingly heavier
The problem of wanting, and the shortage of a large amount of bone-grafting materials needed for bone remoulding is still puzzlement surgeon after this problem and tumor resection
Problem, it is to influence the bottleneck that bone tumour therapy effect and treatment idea develop, and the focus and difficult point studied at present.Traditional
It is to be amputated tumour normal surrounding tissue using bloek-resection for osteoma treatment, autologous bone can be used for the Cranial defect of residual
The methods of inactivation Hui Zhi, bulk bone collection fusion joint, prosthetic replacement, is repaired, but effectively autologous bone can not be carried out
Supplement calcium ion from the external world by oral, it is necessary to supplement calcium ion so that rehabilitation is slower.
The content of the invention
The present invention is for technical deficiencies such as existing anti-bone tumor composite bone reconstruction brackets, there is provided a kind of anti-bone swells
The preparation method of knurl Composite Bone reconstruction bracket.
The present invention, using modified technical scheme, specifically includes following raw material and weight point to solve above-mentioned technical deficiency
Number：The mass parts of polyamide 20~30；Strontium compound is 20~25 mass parts；Hydroxyapatite is 15~20 mass parts；Calcium phosphate
For 50~60 mass parts；Alkaline phosphatase is 5~10 mass parts；Type alpha tricalcium phosphate is 50~60 mass parts；Calcium monohydrogen phosphate is 50
~60 mass parts；Disodium hydrogen phosphate is 20~30 mass parts；Sulfuric acid calcium powder is 20~30 mass parts；Hydrochloride is 5~10 mass
Part；Calcium bicarbonate suspension is 10~20 mass parts；Phosphoric acid is 10~20 mass parts and collagen solution is 10~20 mass
Part.
As a kind of preferred embodiment of the present invention, including following raw material and weight fraction：The mass parts of polyamide 20；Strontium
Compound is 20 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 mass parts；Alkaline phosphatase is 5 mass parts；α-
Tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is 20 mass parts；Sulfuric acid calcium powder is 20 mass
Part；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10 mass parts and collagen solution is 10
Mass parts.
As a kind of preferred embodiment of the present invention, including following raw material and weight fraction：The mass parts of kymene 0；Strontium
Compound is 25 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 mass parts；Alkaline phosphatase is 10 mass parts；
Type alpha tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is 20 mass parts；Sulfuric acid calcium powder is 20 mass
Part；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10 mass parts and collagen solution is 10
Mass parts.
It is as follows as a kind of preferred embodiment of the present invention, manufacturing process steps：
A. above-mentioned raw materials are weighed according to parts by weight, prepares Composite Bone reconstruction bracket；
B. calcium phosphate, tricalcium phosphate, calcium monohydrogen phosphate and sulfuric acid calcium powder are dissolved in calcium bicarbonate suspension and go out decontamination, will
Alkaline phosphatase and disodium hydrogen phosphate are dissolved in the activity that alkaline phosphatase is improved in phosphoric acid；
C. it is polyamide, strontium compound, hydroxyapatite, calcium bicarbonate suspension, hydrochloride, phosphoric acid and collagen is molten
Liquid prepares Composite Bone reconstruction bracket by prior art；
D. after bone remoulding support synthesis to be composite, put and heat in the drying chamber, keep drying indoor temperature at 37 DEG C, and hold
Continuous to dry a week, activity is most strong at a suitable temperature for alkaline phosphatase, promotes the reaction between each element, accelerates Composite Bone
The efficiency of reconstruction bracket sizing；
E. Composite Bone reconstruction bracket is detected according to the standard of national standard, detect qualified support put into it is cold in refrigerating chamber
Hide, further taken out when to be needed.
As a kind of preferred embodiment of the present invention, anti-bone tumor composite bone reconstruction bracket is in preparation described in step c
During remain in the environment of bacteria-and dust-free and operate.
The beneficial effect that is reached of the present invention is：The present invention has good amalgamation, Composite Bone reconstruction bracket and people's bone
After contact, on the one hand the bone of injury is fixed, prevents second hurt, on the other hand can supplement calcium to the bone of injury
Ion, promote bone growth rehabilitation.
Embodiment
A kind of preparation method of anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：Polyamide 20
~30 mass parts；Strontium compound is 20~25 mass parts；Hydroxyapatite is 15~20 mass parts；Calcium phosphate is 50~60 mass
Part；Alkaline phosphatase is 5~10 mass parts；Type alpha tricalcium phosphate is 50~60 mass parts；Calcium monohydrogen phosphate is 50~60 mass parts；Phosphorus
Sour disodium hydrogen is 20~30 mass parts；Sulfuric acid calcium powder is 20~30 mass parts；Hydrochloride is 5~10 mass parts；Calcium bicarbonate hangs
Supernatant liquid is 10~20 mass parts；Phosphoric acid is 10~20 mass parts and collagen solution is 10~20 mass parts.
Described anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：The mass parts of polyamide 20；Strontium
Compound is 20 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 mass parts；Alkaline phosphatase is 5 mass parts；α-
Tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is 20 mass parts；Sulfuric acid calcium powder is 20 mass
Part；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10 mass parts and collagen solution is 10
Mass parts.
Described anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：The mass parts of kymene 0；Strontium
Compound is 25 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 mass parts；Alkaline phosphatase is 10 mass parts；
Type alpha tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is 20 mass parts；Sulfuric acid calcium powder is 20 mass
Part；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10 mass parts and collagen solution is 10
Mass parts.
The preparation method of described anti-bone tumor composite bone reconstruction bracket, manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight, prepares Composite Bone reconstruction bracket；
B. calcium phosphate, tricalcium phosphate, calcium monohydrogen phosphate and sulfuric acid calcium powder are dissolved in calcium bicarbonate suspension and go out decontamination, will
Alkaline phosphatase and disodium hydrogen phosphate are dissolved in the activity that alkaline phosphatase is improved in phosphoric acid；
C. it is polyamide, strontium compound, hydroxyapatite, calcium bicarbonate suspension, hydrochloride, phosphoric acid and collagen is molten
Liquid prepares Composite Bone reconstruction bracket by prior art；
D. after bone remoulding support synthesis to be composite, put and heat in the drying chamber, keep drying indoor temperature at 37 DEG C, and hold
Continuous to dry a week, activity is most strong at a suitable temperature for alkaline phosphatase, promotes the reaction between each element, accelerates Composite Bone
The efficiency of reconstruction bracket sizing；
E. Composite Bone reconstruction bracket is detected according to the standard of national standard, detect qualified support put into it is cold in refrigerating chamber
Hide, further taken out when to be needed.
Anti-bone tumor composite bone reconstruction bracket described in the step c remains at bacteria-and dust-free during preparation
Operated in environment.
Embodiment 1
A kind of preparation method of anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：Polyamide 20
~30 mass parts；Strontium compound is 20~25 mass parts；Hydroxyapatite is 15~20 mass parts；Calcium phosphate is 50~60 mass
Part；Alkaline phosphatase is 5~10 mass parts；Type alpha tricalcium phosphate is 50~60 mass parts；Calcium monohydrogen phosphate is 50~60 mass parts；Phosphorus
Sour disodium hydrogen is 20~30 mass parts；Sulfuric acid calcium powder is 20~30 mass parts；Hydrochloride is 5~10 mass parts；Calcium bicarbonate hangs
Supernatant liquid is 10~20 mass parts；Phosphoric acid is 10~20 mass parts and collagen solution is 10~20 mass parts.
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight, prepares Composite Bone reconstruction bracket；
B. calcium phosphate, tricalcium phosphate, calcium monohydrogen phosphate and sulfuric acid calcium powder are dissolved in calcium bicarbonate suspension and go out decontamination, will
Alkaline phosphatase and disodium hydrogen phosphate are dissolved in the activity that alkaline phosphatase is improved in phosphoric acid；
C. it is polyamide, strontium compound, hydroxyapatite, calcium bicarbonate suspension, hydrochloride, phosphoric acid and collagen is molten
Liquid prepares Composite Bone reconstruction bracket by prior art；
D. after bone remoulding support synthesis to be composite, put and heat in the drying chamber, keep drying indoor temperature at 37 DEG C, and hold
Continuous to dry a week, activity is most strong at a suitable temperature for alkaline phosphatase, promotes the reaction between each element, accelerates Composite Bone
The efficiency of reconstruction bracket sizing；
E. Composite Bone reconstruction bracket is detected according to the standard of national standard, detect qualified support put into it is cold in refrigerating chamber
Hide, further taken out when to be needed.
Polyamide, strontium compound, hydroxyapatite, calcium phosphate, alkaline phosphatase, type alpha tricalcium phosphate in the present embodiment,
Pass through between calcium monohydrogen phosphate, disodium hydrogen phosphate, sulfuric acid calcium powder, hydrochloride, calcium bicarbonate suspension, phosphoric acid and collagen solution
Specific ratio is used in mixed way, and prepares Composite Bone reconstruction bracket by prior art, Composite Bone reconstruction bracket is to due to hair
Raw osteoma and on the one hand the autologous bone cut off plays a part of fixed support, it is autologous bone supplement that on the other hand can be used as calcium source
Calcium ion, promote the growth rehabilitation of bone.
Embodiment 2
A kind of preparation method of anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：Polyamide 20
Mass parts；Strontium compound is 20 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 mass parts；Alkaline phosphatase is 5
Mass parts；Type alpha tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is 20 mass parts；Sulfuric acid calcium powder
For 20 mass parts；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10 mass parts and collagen
Solution is 10 mass parts.
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight, prepares Composite Bone reconstruction bracket；
B. calcium phosphate, tricalcium phosphate, calcium monohydrogen phosphate and sulfuric acid calcium powder are dissolved in calcium bicarbonate suspension and go out decontamination, will
Alkaline phosphatase and disodium hydrogen phosphate are dissolved in the activity that alkaline phosphatase is improved in phosphoric acid；
C. it is polyamide, strontium compound, hydroxyapatite, calcium bicarbonate suspension, hydrochloride, phosphoric acid and collagen is molten
Liquid prepares Composite Bone reconstruction bracket by prior art；
D. after bone remoulding support synthesis to be composite, put and heat in the drying chamber, keep drying indoor temperature at 37 DEG C, and hold
Continuous to dry a week, activity is most strong at a suitable temperature for alkaline phosphatase, promotes the reaction between each element, accelerates Composite Bone
The efficiency of reconstruction bracket sizing；
E. Composite Bone reconstruction bracket is detected according to the standard of national standard, detect qualified support put into it is cold in refrigerating chamber
Hide, further taken out when to be needed.
Polyamide in the present embodiment, strontium compound and alkaline phosphatase usage amount are smaller and coordinate other materials, make
The hardness of Composite Bone reconstruction bracket is remarkably enhanced made of obtaining, and preferably the bone of injury can be fixed,
Be advantageous to the rehabilitation of bone.
Embodiment 3
A kind of preparation method of anti-bone tumor composite bone reconstruction bracket, including following raw material and weight fraction：Kymene 0
Mass parts；Strontium compound is 25 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 mass parts；Alkaline phosphatase is
10 mass parts；Type alpha tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is 20 mass parts；Calcium sulfate
Powder is 20 mass parts；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10 mass parts and collagen egg
White solution is 10 mass parts.
Manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight, prepares Composite Bone reconstruction bracket；
B. calcium phosphate, tricalcium phosphate, calcium monohydrogen phosphate and sulfuric acid calcium powder are dissolved in calcium bicarbonate suspension and go out decontamination, will
Alkaline phosphatase and disodium hydrogen phosphate are dissolved in the activity that alkaline phosphatase is improved in phosphoric acid；
C. it is polyamide, strontium compound, hydroxyapatite, calcium bicarbonate suspension, hydrochloride, phosphoric acid and collagen is molten
Liquid prepares Composite Bone reconstruction bracket by prior art；
D. after bone remoulding support synthesis to be composite, put and heat in the drying chamber, keep drying indoor temperature at 37 DEG C, and hold
Continuous to dry a week, activity is most strong at a suitable temperature for alkaline phosphatase, promotes the reaction between each element, accelerates Composite Bone
The efficiency of reconstruction bracket sizing；
E. Composite Bone reconstruction bracket is detected according to the standard of national standard, detect qualified support put into it is cold in refrigerating chamber
Hide, further taken out when to be needed.
Polyamide in the present embodiment, strontium compound and alkaline phosphatase usage amount are larger and coordinate other materials, make
Composite Bone reconstruction bracket made of obtaining not only has stronger hardness, but also with the function of calcium ion movement, Composite Bone weight
Support is built after being contacted with autologous bone, because human body temperature remains at 37 DEG C, the calcium ion energy on Composite Bone reconstruction bracket
It is enough to be automatically moved in autologous bone, and then promote the growth of autologous bone.
Finally it should be noted that：The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic.
Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., it should be included in the present invention's
Within protection domain.
Claims (5)
1. a kind of preparation method of anti-bone tumor composite bone reconstruction bracket, it is characterised in that including following raw material and weight fraction：
The mass parts of polyamide 20~30；Strontium compound is 20~25 mass parts；Hydroxyapatite is 15~20 mass parts；Calcium phosphate is 50
~60 mass parts；Alkaline phosphatase is 5~10 mass parts；Type alpha tricalcium phosphate is 50~60 mass parts；Calcium monohydrogen phosphate is 50~60
Mass parts；Disodium hydrogen phosphate is 20~30 mass parts；Sulfuric acid calcium powder is 20~30 mass parts；Hydrochloride is 5~10 mass parts；Carbon
Sour hydrogen calcium suspension is 10~20 mass parts；Phosphoric acid is 10~20 mass parts and collagen solution is 10~20 mass parts.
A kind of 2. anti-bone tumor composite bone reconstruction bracket according to claim 1, it is characterised in that including following raw material and
Weight fraction：The mass parts of polyamide 20；Strontium compound is 20 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 matter
Measure part；Alkaline phosphatase is 5 mass parts；Type alpha tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate is
20 mass parts；Sulfuric acid calcium powder is 20 mass parts；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is 10
Mass parts and collagen solution are 10 mass parts.
A kind of 3. anti-bone tumor composite bone reconstruction bracket according to claim 1, it is characterised in that including following raw material and
Weight fraction：The mass parts of kymene 0；Strontium compound is 25 mass parts；Hydroxyapatite is 15 mass parts；Calcium phosphate is 50 matter
Measure part；Alkaline phosphatase is 10 mass parts；Type alpha tricalcium phosphate is 50 mass parts；Calcium monohydrogen phosphate is 50 mass parts；Disodium hydrogen phosphate
For 20 mass parts；Sulfuric acid calcium powder is 20 mass parts；Hydrochloride is 5 mass parts；Calcium bicarbonate suspension is 10 mass parts；Phosphoric acid is
10 mass parts and collagen solution are 10 mass parts.
4. a kind of preparation method for preparing a kind of anti-bone tumor composite bone reconstruction bracket described in one of claims 1 to 3, it is special
Sign is that manufacturing process steps are as follows：
A. above-mentioned raw materials are weighed according to parts by weight, prepares Composite Bone reconstruction bracket；
B. calcium phosphate, tricalcium phosphate, calcium monohydrogen phosphate and sulfuric acid calcium powder are dissolved in calcium bicarbonate suspension and go out decontamination, by alkalescence
Phosphatase and disodium hydrogen phosphate are dissolved in the activity that alkaline phosphatase is improved in phosphoric acid；
C. polyamide, strontium compound, hydroxyapatite, calcium bicarbonate suspension, hydrochloride, phosphoric acid and collagen solution are led to
Cross prior art and prepare Composite Bone reconstruction bracket；
D. after bone remoulding support synthesis to be composite, put and heat in the drying chamber, keep drying indoor temperature at 37 DEG C, and persistently do
In a dry week, activity is most strong at a suitable temperature for alkaline phosphatase, promotes the reaction between each element, accelerates compound bone remoulding
The efficiency of support sizing；
E. Composite Bone reconstruction bracket is detected according to the standard of national standard, detects qualified support and put into refrigerating chamber and refrigerate,
Further taken out when to be needed.
A kind of 5. preparation method of anti-bone tumor composite bone reconstruction bracket according to claim 4, it is characterised in that step
Operated in the environment that anti-bone tumor composite bone reconstruction bracket described in c remains at bacteria-and dust-free during the preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710570380.6A CN107551319A (en) | 2017-07-13 | 2017-07-13 | A kind of preparation method of anti-bone tumor composite bone reconstruction bracket |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710570380.6A CN107551319A (en) | 2017-07-13 | 2017-07-13 | A kind of preparation method of anti-bone tumor composite bone reconstruction bracket |
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| CN107551319A true CN107551319A (en) | 2018-01-09 |
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| CN201710570380.6A Pending CN107551319A (en) | 2017-07-13 | 2017-07-13 | A kind of preparation method of anti-bone tumor composite bone reconstruction bracket |
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| CN101549176A (en) * | 2009-05-08 | 2009-10-07 | 武汉理工大学 | Release oxygen type stephanoporate abio/organic composite material stent |
| WO2016130559A1 (en) * | 2015-02-10 | 2016-08-18 | Lifenet Health | Biologically functional soft tissue scaffolds and implants |
| WO2017045084A1 (en) * | 2015-09-14 | 2017-03-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Composition for bone regeneration |
| US20170128627A1 (en) * | 2015-11-02 | 2017-05-11 | Amrita Vishwa Vidyapeetham | Porous composite fibrous scaffold for bone tissue regeneration |
| CN106823008A (en) * | 2016-12-30 | 2017-06-13 | 北京爱康宜诚医疗器材有限公司 | Bone renovating material and preparation method thereof |
-
2017
- 2017-07-13 CN CN201710570380.6A patent/CN107551319A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101420922A (en) * | 2005-12-06 | 2009-04-29 | 埃特克斯公司 | Porous calcium phosphate bone material |
| CN101318641A (en) * | 2008-07-04 | 2008-12-10 | 华中科技大学 | Method for preparing nano-calcium-phosphor biological material with continuous dialysis mode |
| CN101549176A (en) * | 2009-05-08 | 2009-10-07 | 武汉理工大学 | Release oxygen type stephanoporate abio/organic composite material stent |
| WO2016130559A1 (en) * | 2015-02-10 | 2016-08-18 | Lifenet Health | Biologically functional soft tissue scaffolds and implants |
| WO2017045084A1 (en) * | 2015-09-14 | 2017-03-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Composition for bone regeneration |
| US20170128627A1 (en) * | 2015-11-02 | 2017-05-11 | Amrita Vishwa Vidyapeetham | Porous composite fibrous scaffold for bone tissue regeneration |
| CN106823008A (en) * | 2016-12-30 | 2017-06-13 | 北京爱康宜诚医疗器材有限公司 | Bone renovating material and preparation method thereof |
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