CN107536816A - A kind of Protostat - Google Patents
A kind of Protostat Download PDFInfo
- Publication number
- CN107536816A CN107536816A CN201610492111.8A CN201610492111A CN107536816A CN 107536816 A CN107536816 A CN 107536816A CN 201610492111 A CN201610492111 A CN 201610492111A CN 107536816 A CN107536816 A CN 107536816A
- Authority
- CN
- China
- Prior art keywords
- parts
- protostat
- metronidazole
- essence
- solubilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of Protostat, it is characterised in that the pharmaceutical preparation prescription parts by weight are calculated as：10 20 parts of 20 80 parts of metronidazole, 40 200 parts of filler, 10 20 parts of essence, 20 40 parts of flavouring, 30 50 parts of solubilizer, 10 150 parts of disintegrant and lubricant.This product is in good taste, and bioavilability is high, and preparation method is simple and easy, easy to implement, prepared metronidazole oral disnitegration tablet out, and stability is good.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, and in particular to a kind of Protostat.
Background technology
Protostat, which is mainly used in preventing and treating caused by anaerobic bacteria, to be infected, such as respiratory tract, alimentary canal female reproduction
The anaerobic infection at the position such as system, lower respiratory tract, skin and soft tissue, bone and joint, to septicemia, endocarditis, meninx sense
Contaminate and also effective using colitis caused by antibiotic.Lockjaw is treated often to be combined with tetanus antitoxin (TAT).Also it can use
Infected in oral cavity anaerobium.There is presently no the patent of the preparation technology of metronidazole mouth this film.
The content of the invention
A kind of the present invention is intended to provide Protostat in good taste, bioavilability is high, stability is good.
For achieving the above object, a kind of Protostat of the present invention, technical scheme are：
A kind of Protostat of the present invention, it is characterised in that the pharmaceutical preparation prescription parts by weight are calculated as：Metronidazole 20-
80 parts, filler 40-200 parts, essence 10-20 parts, flavouring 20-40 parts, solubilizer 30-50 parts, disintegrant 10-150 parts and
Lubricant 10-20 parts.
Specifically, the pharmaceutical preparation prescription parts by weight are calculated as：40 parts of metronidazole, 60 parts of filler, 12 parts of essence, flavoring
14 parts of 25 parts of agent, 40 parts of solubilizer, 40 parts of disintegrant and lubricant.
A kind of Protostat of the present invention is oral formulations, and specifically, the oral formulations are oral disintegrating tablet.
A kind of Protostat of the present invention, the filler described in the oral formulations are mannitol, lactose, sucrose, Portugal
One or more in grape sugar, starch, pregelatinized starch and microcrystalline cellulose；Described essence is flavoring pineapple essence；Described rectifys
Taste agent is the one or more in ethylmaltol, xylitol, Aspartame；Described solubilizer is Tween 80, dodecyl
One or more in sodium sulphate, Ac-Di-Sol, sodium carboxymethyl starch；Described disintegrant is CMS
One or more in sodium, Ac-Di-Sol, hydroxypropylcellulose and microcrystalline cellulose；Described lubricant is dioxy
One or more in SiClx, magnesium stearate, talcum powder, polyethylene glycol.
The preparation method of oral disintegrating tablet of the present invention is：Metronidazole, solubilizer, disintegrant, lubricant are weighed by formula simultaneously
30 mesh sieves are crossed, and weighs essence, flavouring by formula and crosses 60 mesh sieves, the filler with being weighed by formula is mixed together
It is even.Direct tablet compressing after adjustment sheet weight, forms metronidazole oral disintegrating tablet.
Prescription and technological advantage analysis of the present invention：Oral disintegrating tablet can be made compared with ordinary tablet in oral cavity by the infiltration of saliva
With rapid disintegration dissolving is come.Oral disintegrating tablet disintegration rate is fast, it is rapid to absorb, and need not be drunk water after taking.
Embodiment
Example below is only of the invention to further illustrate, scope that the invention is not limited in any way.
Embodiment 1
Metronidazole 40g, Ac-Di-Sol 40g, microcrystalline cellulose 40g, magnesium stearate 14g and excessively 30 are weighed by formula
Mesh sieve, and weigh flavoring pineapple essence 12g, Aspartame 25g by formula and cross 60 mesh sieves, with the mannitol 60g weighed by formula
It is mixed together uniformly.Direct tablet compressing after adjustment sheet weight, forms metronidazole oral disintegrating tablet.
Embodiment 2
Metronidazole 40g, lauryl sodium sulfate 35g, sodium carboxymethyl starch 40g, talcum powder 10g are weighed by formula and cross 30 mesh
Sieve, and weigh flavoring pineapple essence 15g, xylitol 20g by formula and cross 60 mesh sieves, with mannitol 30g, the sucrose weighed by formula
20g is mixed together uniformly.Direct tablet compressing after adjustment sheet weight, forms metronidazole oral disintegrating tablet.
Embodiment 3
Metronidazole 40g, lauryl sodium sulfate 30g, sodium carboxymethyl starch 30g, microcrystalline cellulose 10g, talcum are weighed by formula
Powder 10g simultaneously crosses 30 mesh sieves, and weighs flavoring pineapple essence 15g, Aspartame 20g by formula and cross 60 mesh sieves, with being weighed by formula
Filler be mixed together uniformly.Direct tablet compressing after adjustment sheet weight, forms metronidazole oral disintegrating tablet.
Embodiment 4
By formula weigh metronidazole 40g, Ac-Di-Sol 35g, sodium carboxymethyl starch 20g, microcrystalline cellulose 20g,
Magnesium stearate 15g simultaneously cross 30 mesh sieves, and by formula weigh flavoring pineapple essence 20g, Aspartame 15g and cross 60 mesh sieves, with by with
The filler just weighed is mixed together uniformly.Direct tablet compressing after adjustment sheet weight, forms metronidazole oral disintegrating tablet.
Each embodiment quality control data：
Claims (6)
1. a kind of Protostat, it is characterised in that the pharmaceutical preparation prescription parts by weight are calculated as：Metronidazole 20-80 parts, filling
Agent 40-200 parts, essence 10-20 parts, flavouring 20-40 parts, solubilizer 30-50 parts, disintegrant 10-150 parts and lubricant 10-
20 parts.
2. a kind of Protostat according to claim 1, it is characterised in that the pharmaceutical preparation prescription parts by weight are calculated as：
14 parts of 40 parts of metronidazole, 60 parts of filler, 12 parts of essence, 25 parts of flavouring, 40 parts of solubilizer, 40 parts of disintegrant and lubricant.
3. a kind of Protostat according to claim 1, it is characterised in that the pharmaceutical preparation is oral formulations.
4. a kind of Protostat according to claim 3, it is characterised in that the oral formulations are oral disnitegration tablet.
5. a kind of Protostat according to claim 4, it is characterised in that the filler described in the oral formulations is sweet dew
One or more in alcohol, lactose, sucrose, glucose, starch, pregelatinized starch and microcrystalline cellulose；Described essence is spinach
Trailing plants essence；Described flavouring is the one or more in ethylmaltol, xylitol, Aspartame；Described solubilizer is
One or more in Tween 80, lauryl sodium sulfate, Ac-Di-Sol, sodium carboxymethyl starch；Described collapses
Solution agent is the one or more in sodium carboxymethyl starch, Ac-Di-Sol, hydroxypropylcellulose and microcrystalline cellulose；Institute
The lubricant stated is the one or more in silica, magnesium stearate, talcum powder, polyethylene glycol.
6. a kind of Protostat according to claim 5, it is characterised in that the preparation method of the oral disnitegration tablet is：Press
Formula weighs metronidazole, solubilizer, disintegrant, helps and collapse agent, lubricant and cross 30 mesh sieves, and weighs essence, flavoring by formula
Agent simultaneously crosses 60 mesh sieves, and the filler with being weighed by formula is mixed together uniformly, direct tablet compressing after adjustment sheet weight, forms metronidazole mouth
Disintegrating tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610492111.8A CN107536816A (en) | 2016-06-29 | 2016-06-29 | A kind of Protostat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610492111.8A CN107536816A (en) | 2016-06-29 | 2016-06-29 | A kind of Protostat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107536816A true CN107536816A (en) | 2018-01-05 |
Family
ID=60963141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610492111.8A Pending CN107536816A (en) | 2016-06-29 | 2016-06-29 | A kind of Protostat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107536816A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420800A (en) * | 2018-04-24 | 2018-08-21 | 南京双科医药开发有限公司 | A kind of Metric 21 and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452963A (en) * | 2002-04-23 | 2003-11-05 | 北京德众万全药物技术开发有限公司 | Metronidazole prepn |
| CN101461789A (en) * | 2008-09-26 | 2009-06-24 | 徐新盛 | Technique for preparing metronidazole benzoate dispersible tablet |
| CN102784120A (en) * | 2012-08-23 | 2012-11-21 | 海南卫康制药(潜山)有限公司 | Metronidazole composition freeze-dried disintegrating tablets for vaginas and preparation method thereof |
| CN103402497A (en) * | 2010-12-02 | 2013-11-20 | 阿普塔利斯医药科技公司 | Rapidly dispersing granules, orally disintegrating tablets and methods |
| CN104887636A (en) * | 2015-06-16 | 2015-09-09 | 吉林万通药业集团郑州万通复升药业股份有限公司 | Metronidazole tablet and preparation method thereof |
-
2016
- 2016-06-29 CN CN201610492111.8A patent/CN107536816A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452963A (en) * | 2002-04-23 | 2003-11-05 | 北京德众万全药物技术开发有限公司 | Metronidazole prepn |
| CN101461789A (en) * | 2008-09-26 | 2009-06-24 | 徐新盛 | Technique for preparing metronidazole benzoate dispersible tablet |
| CN103402497A (en) * | 2010-12-02 | 2013-11-20 | 阿普塔利斯医药科技公司 | Rapidly dispersing granules, orally disintegrating tablets and methods |
| CN102784120A (en) * | 2012-08-23 | 2012-11-21 | 海南卫康制药(潜山)有限公司 | Metronidazole composition freeze-dried disintegrating tablets for vaginas and preparation method thereof |
| CN104887636A (en) * | 2015-06-16 | 2015-09-09 | 吉林万通药业集团郑州万通复升药业股份有限公司 | Metronidazole tablet and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 叶勇主编: "《制药工艺学》", 28 February 2014, 华南理工大学出版社 * |
| 方亮主编: "《药剂学》", 31 March 2016, 中国医药科技出版社 * |
| 杜利月: ""甲硝唑口含片制备工艺研究"", 《中国医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420800A (en) * | 2018-04-24 | 2018-08-21 | 南京双科医药开发有限公司 | A kind of Metric 21 and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102858373B (en) | Easily dosable solid preparation | |
| JP2009545557A (en) | Stomach retention delivery system | |
| JP2014214125A (en) | Method for producing tablet | |
| JP2006070046A (en) | Quick disintegrable solid preparation | |
| US20050163857A1 (en) | Clarithromycin formulations having improved bioavailability | |
| CN107536816A (en) | A kind of Protostat | |
| JP6864970B2 (en) | Gastrointestinal drug composition | |
| JP5945191B2 (en) | Intraoral quick disintegrating tablet | |
| CN106137988A (en) | A kind of metronidazole solid preparation and preparation method thereof | |
| TW201517933A (en) | Ultrafast-disintegrating tablet and method for manufacturing same | |
| JP6513702B2 (en) | Super fast disintegrating tablet and method for producing the same | |
| US20020006433A1 (en) | Pharmaceutical formulations | |
| JP6373616B2 (en) | Oral composition | |
| JP3230002B2 (en) | Pharmaceutical formulations | |
| TWI762450B (en) | Ultra-high-speed disintegrating tablet and its manufacturing method | |
| TW201517934A (en) | Method for producing tablet | |
| JP2008162989A (en) | Tablet quickly disintegrating in oral cavity | |
| CN103735524A (en) | Cefixime chewable tablet and preparation method thereof | |
| CN107029208A (en) | It is a kind of to treat lisinopril compound preparation of angiocardiopathy and preparation method thereof | |
| CN103919790B (en) | A kind of preparation method of sulfaguanidine-trimethoprim effervescent tablet | |
| CN107510670A (en) | A kind of Sugarless type Wei ShengsuK ＆D oral disnitegration tablets | |
| JP5962161B2 (en) | Eustachian tube treatment | |
| CN104138361B (en) | Andrographolide dispersible tablet and preparation method thereof | |
| CN103156988A (en) | Dispersible tablet for clearing heat, relieving sore-throat, detoxifying and relieving pain, and preparation method for same | |
| CN102370621A (en) | Solid preparation with cefotiam hexetil as active component |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180105 |