CN107530701A - For liquid assigned unit and method - Google Patents
For liquid assigned unit and method Download PDFInfo
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- CN107530701A CN107530701A CN201680027425.9A CN201680027425A CN107530701A CN 107530701 A CN107530701 A CN 107530701A CN 201680027425 A CN201680027425 A CN 201680027425A CN 107530701 A CN107530701 A CN 107530701A
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- plate
- liquid
- flow export
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- strong points
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
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- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
A kind of liquid dispensing apparatus, including：Plate, there is flow export in the end of plate；And actuating unit, it includes being used at least two strong points for supporting the plate, wherein, the first surface of the plate is accommodated at least two strong points, and actuating mechanism, actuating mechanism is suitable to the part deformation for making the plate between at least two strong points, so that the end of the plate is deflected to move flow export.There is disclosed herein a kind of actuating unit, plate and the method distributed for liquid.
Description
Technical field
Embodiment is related generally to for liquid assigned unit and method.
Background technology
Liquid distribution on substrate can be divided into contact and contactless mode.Liquid distribution may include distribute liquid flow,
Distribute the liquid of discrete volume, liquid droplet distribution, droplet formation, drop injection etc..In contact is printed, drawn using capillary pin
Liquid is simultaneously transferred to substrate by liquid by the physical contact of pin and substrate surface.Contactless liquid assigning process on substrate
In, generally use is mechanically actuated to distribute liquid via small flow export (small flow-exit).This actuation technology includes
Thermal actuation, acoustic actuator, piezoelectricity braking, pneumatically actuated and electrostatically actuated.
In biomedical applications, usually require that the part contacted with liquid keeps thoroughly cleaning and entered in each application
Row sterilizing.Ideally, preferably used part is handled after each application, so that new has been subjected to sterilizing
Part can be used for applying next time.However, the technology currently used for liquid distribution needs possible hardly possible after each application
With the equipment for cleaning and sterilizing, or processing cost is too high after each application.
Exemplary embodiment is provided for liquid assigned unit and method, and it is sought in solving the above problems at least
Some problems.
The content of the invention
According to various embodiments, there is provided a kind of liquid dispensing apparatus, including plate, the end of the plate have flow export；
And actuating unit, the actuating unit includes being used at least two strong points for supporting the plate, wherein the first of the plate
Surface is accommodated at least two strong points；And actuating mechanism, its be suitable to make the plate between at least two strong points
Part deformation so that the end of the plate is deflected to move flow export.
According to various embodiments, there is provided a kind of actuating unit for liquid dispensing apparatus.The actuating unit includes
Suitable at least two strong points of the first surface of accommodates plate, for supporting the plate；And actuating mechanism, suitable for making described first
Surface is contained in part of the plate at least two strong point between at least two strong point of the plate
Deformation, to cause the deflection of the end of the plate with the mobile flow export in the end of the plate.
According to various embodiments, there is provided a kind of plate for liquid dispensing apparatus.The plate includes：At the end of the plate
The flow export in portion, wherein the first surface of the plate is suitable to be accommodated at least two strong points for supporting the plate,
And the plate that wherein, the first surface of the plate is accommodated at least two strong points be suitable to make the plate
Part deformation between at least two strong points, to cause the deflection of the end of the plate to move flow export.
According to various embodiments, there is provided a kind of method for liquid distribution.This method includes：Make plate at least two
Part deformation between the strong point, to cause the deflection of the end of the plate to move the flow export in the end of the plate, its
Described in plate be supported at least two strong points, the first surface of the plate is accommodated at least two strong points.
Brief description of the drawings
In the accompanying drawings, identical reference refers to identical part generally in different views.Accompanying drawing is not necessarily pressed
Ratio is drawn, but is generally placed upon the principle for stressing the present invention.In the following description, describe with reference to the following drawings various
Embodiment, wherein：
Fig. 1 shows the schematic block diagram of the liquid dispensing apparatus according to various embodiments；
Fig. 2 shows the schematic diagram of the basic operation of the liquid dispensing apparatus according to various embodiments；
Fig. 3 shows the schematic diagram of the liquid dispensing apparatus according to various embodiments；
Fig. 4 shows the analog result of the vibration of the twisted plate of the simple support according to various embodiments；
Fig. 5 show according to various embodiments produce and collect on planar substrates by liquid dispensing apparatus it is accurate
The photo of the liquid array of control.
Fig. 6 A show the circular slab of the flow export with the circumference around circular slab according to various embodiments；With
And Fig. 6 B show the rectangular slab of the flow export that there is the width along the end of plate to arrange according to various embodiments.
Specific embodiment
The embodiment described below in the case of device or equipment is similarly effective for corresponding method, otherwise also
So.Moreover, it will be appreciated that embodiment described below can combine, for example, a part of of one embodiment can be with another reality
Apply the part combination of example.
It should be understood that " above ", " top ", " top ", " bottom ", " following ", " side ", " below ", " left side ", " right side
For the ease of the purpose that uses and contribute to when side ", " above ", " sidepiece ", " upward ", " downward " etc. use in the following description
Understand relative position or direction, and be not intended to the direction for limiting any equipment or structure, or any equipment or structure is any
Part.
Fig. 1 shows the schematic block diagram of the liquid dispensing apparatus 100 according to various embodiments.Liquid dispensing apparatus 100
It may include plate 110.Plate 110 can have two surfaces, such as first surface and the second surface relative with first surface,
The form of sheet material or panel.Plate 110 can be any shape, such as rectangle, square, ellipse, circle etc..Plate 110 can be with
There is flow export in its end.Flow export can be the form of nozzle.Flow export, which may be adapted to accommodate, is used for subsequent liquid point
The liquid matched somebody with somebody.According to various embodiments, liquid distribution can include distribution liquid flow, the liquid for distributing discrete volume, drop point
Match somebody with somebody, droplet formation, drop injection etc..
Liquid dispensing apparatus 100 may also include actuating unit 130.Actuating unit 130 can be operated to the stream of plate 110
Outlet distribution liquid.According to various embodiments, distribution liquid can include distribution liquid flow, the liquid for distributing discrete volume, divide
With drop or injection drop etc..Actuating unit 130 may include at least two strong points 134 for supporting plate 110.Plate 110
First surface may be accommodated at least two strong points 134 of actuating unit 130.In other words, actuating unit 130 can be with
Including support meanss, for example, at least two strong points 134, it is suitable at least two opening positions on the first surface of plate 110
Supporting plate 110.
Actuating unit 130 may also include actuating mechanism 132.Actuating mechanism 132 is suitable to make the plate between 1: 134
110 part deformation, so that the end of plate 110 is deflected to move flow export.For example, actuating mechanism 132 may be adapted to
The relative second surface applying power of the first surface of plate 110 between at least two strong points 134 so that plate 110 at least
Part deformation between two strong points 134.Therefore, the actuating mechanism 132 of actuating unit 130 can be operated to create
Power, when plate 110 is supported at least two strong points 134, the power can point to the second surface of plate 110, wherein plate 110
First surface be accommodated at least two strong points 134.The power can between at least two strong points 134, plate 110
The second surface of plate 110 is acted in the part so that part of the plate 110 between at least two strong points 134 is deformable.Cause
The second surface for the plate 110 that be may act on for the power as caused by actuating mechanism 132 between at least two strong points 134, so plate
The deformation of 110 part between at least two strong points 134 can be implemented, while each at least two strong points 134
It is individual to apply opposite power on the first surface of plate 110.Because the end of plate 110 can be the freedom that can move freely
End, so the deformation of the part between at least two strong points 134 of plate 110 may cause the deflection of the end of plate 110, makes
The flow export obtained on the end of plate 110 can move according to the deflection of the end of plate 110.
According to various embodiments, liquid can be included in flow export via surface tension.Because of the deformation institute of the part of plate 110
The deflection of end of caused plate 110 and the motion of caused flow export may cause liquid to overcome surface tension so that liquid
It can be distributed at flow export.The liquid of distribution can be the liquid or drop of liquid flow, discrete volume.
Therefore, single applying power on the plate 110 between at least two strong points 134, at least two strong points 134 are passed through
Between the part of plate 110 may deform, so as to cause the end of plate 110 to deflect, for moving single flow export to distribute liquid
Body.In the embodiment that the end of plate 110 has multiple flow exports, multiply liquid can be formed while single applies the power
Stream.In another embodiment, the liquid of multiply discrete volume can be distributed simultaneously.In another embodiment, can be simultaneously
Distribute multiply drop.
As described above, the end that liquid dispensing apparatus 100 can be included in plate 110 has the plate 110 of flow export；And cause
Moving cell 130, it includes at least two strong points 134 for supporting plate 110, and the first surface of wherein plate 110 is accommodated in
On at least two strong points 134；With actuating mechanism 132, it is suitable to make the plate 110 between at least two strong points 134
Part deformation, so that the end of plate 110 is deflected to move flow export.Actuating mechanism 132 can be adapted to positioned at least
The relative second surface applying power of the first surface of plate 110 between two strong points 134, so that at least two strong points 134
Between plate 110 the part deformation.
According to various embodiments, the actuating mechanism 132 of actuating unit 130 can be further adapted for periodically (generally with
Several hertz of frequency, such as 1-10Hz is to several KHzs, such as 2000-5000Hz) make between at least two strong points 134
Plate 110 part deformation so that the end of plate 110, which produces, to be vibrated so that flow export vibrates.For example, actuating mechanism 132 can
It is suitable for periodically to the second surface applying power of the plate 110 between at least two strong points 134, periodically to make at least
The part deformation of plate 110 between two strong points 134.Therefore, when periodically applying power, such as repeatedly apply and remove
During power, the part of plate 110 may be by flexibly repeated deformation.In other words, the part of plate 110 can repeatedly deform simultaneously
Return to its original-shape.The repetition elastic deformation of the part of plate 110 may cause the end of plate 110 repeatedly to deflect and return
Return to its initial construction.The repetition deflection and return of the end of plate 110, i.e. the vibration of the end of plate 110 can respectively repeatedly
Make flow export mobile and it is returned to and return to initial position from initial position, so that flow export vibrates.In flow export
During each circulation of vibration, liquid can be allocated.Therefore, in one embodiment, the vibration of flow export can be passed through
Continuously distribute multiply liquid flow.In another embodiment, the vibration continuous dispensing multiply discrete bodies of flow export can be passed through
Long-pending liquid.In another embodiment, multiply drop can continuously be distributed by the vibration of flow export.
According to various embodiments, actuating mechanism 132 may be adapted to deform plate 110 in response to pumping signal.Therefore, activate
Mechanism 132 can be operable to deform plate 110 based on the pumping signal received by actuating mechanism 132.Advantageously, liquid distributes
Device 100 can be sent to the pumping signal of actuating mechanism 132 easily to operate by control.
According to various embodiments, pumping signal can include depending on the various types of signals that how distribute liquid.
For example, pumping signal can include periodic signal or pulse signal.Cyclical signal can include such as square wave or sine wave
Periodic waveform.When it is expected that the volume of liquid of distribution is more than the volume of the liquid distributed in the single vibration of flow export,
Periodic signal may be used as pumping signal, to control actuating mechanism 132 to make the periodically deforming of plate 110, so that the end of plate 110
Generation is vibrated so that flow export periodically vibrates.Therefore, when flow export periodically vibrates, can with repeated dispensing liquid,
So that the liquid of required volume can be with accumulation distribution.When needing disposable distribution liquid, can be made using individual pulse signal
Actuating mechanism 132 is controlled for pumping signal, is once deformed for producing plate 110 so that the end of plate 110 is deflected with movement
Flow export, for performing disposable liquid distribution.Therefore, the amount of liquid for it is expected distribution can be accurately controlled with pumping signal.
According to various embodiments, the actuating mechanism 132 of actuating unit 130 can include rotary cam structure.Rotate cam
Mechanism can convert rotational motion to move along a straight line, and be applied with the second surface to the plate 110 between at least two strong points 134
Reinforcing.
According to various embodiments, rotary cam structure can be arranged at least two strong points 134 and between so that
Plate 110 can be sandwiched between rotary cam structure and at least two strong points 134.In this arrangement, the first surface of plate 110
It may be accommodated at least two strong points 134, and the second surface of plate 110 can be towards rotary cam structure.
According to various embodiments, rotary cam structure can include the rotation of the second surface suitable for direct contact plate 110
Cam, for power to be applied directly to the second surface of plate 110.In this arrangement, it can be plate cam to rotate cam
Or the disc cam with eccentrical shape.Rotation cam, which can enclose, to be rotated about the axis.It can be abutment plate 110 to make cam rotation
Point on second surface slides the periphery of rotation cam.Radial displacement and axis due to the periphery of the rotation cam of eccentrical shape
Difference, therefore when rotate cam rotation when, power can be applied directly on the point on the second surface of plate 110.
According to various embodiments, rotation cam can not directly contact with plate 110.On the contrary, cam can be with the end of bar
Contact, and the other end of bar can contact with plate 110.In this arrangement, cam rotation is made to cause the reciprocal of bar
(front and rear) motion so that bar can be applied a force upon on the second surface of plate 110.
According to various embodiments, the actuating mechanism 132 of actuating unit 130 can include solenoid actuated mechanism.Electromagnet
Actuating mechanism can be directed to use with the part that electromagnetic force carrys out Mobile electromagnetic iron actuating mechanism, and the second of plate 110 is applied to produce
Power on surface.
According to various embodiments, solenoid actuated mechanism can include electromagnet.Solenoid actuated mechanism may also include with
Electromagnet vertically separates and relative to the moveable permanent magnet of electromagnet.Electromagnet can be arranged at least two strong points
Between 134 and towards the first surface for the plate 110 being contained at least two strong points 134.Permanent magnet can be arranged in electromagnetism
Above iron and towards the second surface of plate 110.Therefore, plate 110 can be sandwiched between permanent magnet and electromagnet.In other words,
Plate 110 can separate permanent magnet and electromagnet and at least two strong points 134.
In addition, electromagnet is operable magnetically to attract permanent magnet, permanent magnet is set to be moved relative to electromagnet, so that permanent magnetism
Second surface applying power of the body to the plate 110 between at least two strong points 134 so that between at least two strong points 134
The part deformation of plate 110.Therefore, when electromagnet is energized to attract permanent magnet, permanent magnet can be attracted and towards electromagnet
It is mobile.Because plate 110 is suitable to separate electromagnet and permanent magnet, as permanent magnet can move towards electromagnet movement, permanent magnet
In the second surface for moving plate 110.Therefore, permanent magnet can be with the second surface of applying power and pushing plate 110, so that at least two
The part deformation of plate 110 between the strong point 134.
According to various embodiments, the arrangement of electromagnet and permanent magnet can overturn.In this reverse arrangement, electromagnet
Can be above permanent magnet, and electromagnet can move relative to permanent magnet.Therefore, electromagnet can be moved to plate 110
Second surface in the second surface of applying power and pushing plate 110 so that plate 110 between at least two strong points 134
The electromagnet of part deformation.
According to various embodiments, actuating mechanism 132 can also include being suitable to based on pumping signal control solenoid actuated machine
The controller of the operation of structure.Controller can be with control voltage and electric current to encourage electromagnetism in response to the pumping signal received
Iron, to control the intensity of attraction.Controller is also based on received periodic waveform (such as the square wave of various frequencies
Or sine wave) row energization is entered to electromagnet, periodically to the second surface applying power of plate 110, to make at least two strong points
Deform the part periodic of plate 110 between 134.
According to various embodiments, at least two strong points 134 may be adapted to removably accommodates plate 110.Therefore, plate 110
It can be simply accommodated at least two strong points 134 so that plate 110 can be dismantled easily.For example, plate 110 is in quilt
It can be dismantled after being placed at least two strong points 134 at least two strong points 134.Plate 110 can also simply by
Place and be supported at least two strong points 134, the two strong points can be spaced apart to provide enough branch for plate 110
Support.The strong point 134 of plate 110 and at least two can also include being used to plate 110 being detachably attached at least two strong points
134 buckle installation attachment arrangement (snap and fit attachement means).Plate 110 further can simply make
It is clamped or is attached with magnet.Advantageously, plate 110 can be dismantled easily from liquid dispensing apparatus 100, to make every time
Plate 110 is cleaned and sterilized afterwards with plate 110.Removably accommodating can also allow to make in liquid dispensing apparatus 100
With disposable plate.
According to various embodiments, flow export can be integrally formed with plate 110.Therefore, plate 110 and flow export can be formed
It is integrated.Advantageously, plate 110 can be manufactured with low cost, and plate 110 can be manufactured to disposable unit.
According to various embodiments, flow export can be attached to the separate part of plate 110.
According to various embodiments, plate 110 can include the microfluidic channel fluidly connected with flow export.Microfluidic channel can
To allow liquid flow to enter flow export so that flow export can be by the liquid filling for distribution.
According to various embodiments, microfluidic channel can be integrally formed with plate 110.Therefore, plate 110 and microfluidic channel
It can be formed and be integrated.
According to various embodiments, microfluidic channel can be attached to the separate part of the flow export of plate 110.
According to various embodiments, liquid dispensing apparatus 100 can include being suitable to the liquid for supplying liquid to microfluidic channel
Body source.
According to various embodiments, fluid supply can be included in the liquid memory on plate 110.Liquid memory may be adapted to store up
Liquid storage body.Liquid memory can be in fluid communication via microfluidic channel and flow export so that liquid can be from liquid memory
Flow export is flow to by microfluidic channel.
According to various embodiments, liquid memory can be integrally formed with plate 110.
According to various embodiments, liquid memory can also be attached to the separate part of the flow export of plate 110.
According to various embodiments, outflow into can be guided liquid from fluid supply by pressurized stream (pressurized flow)
Mouth guides liquid memory into.
According to various embodiments, the distance between the midpoint of line of the end of plate 110 with being connected at least two strong points 134
Twice of any one at least two strong points 134 with the distance between midpoint can be more than.Advantageously, when from plate 110
Distance measured by end to the midpoint between at least two strong points 134 is more than any at least two strong points 134
When twice (or the measured distance between at least two strong points 134) of individual measured distance between midpoint, plate
The deflection of 110 end is likely larger than the deformation that the part of the plate 110 between at least two strong points 134 is undergone.Therefore,
The deflection of the end of plate 110 can be putting for the deformation that the part of the plate 110 between at least two strong points 134 is undergone
Greatly.When power periodically or is cyclically applied to plate 110, the vibration of the end of plate 110 can be at least two strong points 134
Between plate 110 the amplification of periodicity elastic deformation undergone of part.Advantageously, enlarge-effect can allow in plate 110
It is upper to apply small power to realize desired deflection or vibration to distribute liquid from the flow export of the end of plate 110.
According to various embodiments, plate 110 may include multiple flow exports.Advantageously, using multiple flow exports, by plate
110 apply single power to produce single deflection in the end of plate 110, can form multiply liquid flow or multiply discrete bodies simultaneously
Long-pending liquid or multiply drop,.
According to various embodiments, plate 110 can be rectangular shape, and flow export or multiple flow exports can be in rectangles
On one end of plate 110.
According to various embodiments, plate 110 can be circular shape, and multiple flow exports can surround circular slab 110
Circle distribution.
According to various embodiments, plate 110 can be made up of the material selected from plastics, copper, aluminium or stainless steel.Advantageously, material
Material can be made up of lower cost materials and can be deformable.In addition, by using the nonmagnetic substance for plate 110,
Solenoid actuated mechanism can be used for actuating unit 130.
According to various embodiments, at least two strong points 134 can be respectively included in two separated supporting constructions extremely
Few two separated points.For example, actuating unit 130 can include two separated supporting constructions.Two separated supporting constructions
In each a strong point can be provided.
According to various embodiments, at least two strong points 134 may include at least two points in the supporting construction points opened.Example
Such as, actuating unit 130 may include a supporting construction for including at least two strong points 134.Therefore, a supporting construction can
To be annular supporting structure.Annular supporting structure can include at least two strong points of the first surface for accommodates plate 110
134.In one embodiment, annular supporting structure is applicable to support circular slab, and the circular slab has the circle along circular slab
Multiple flowings outlet of week distribution.
According to various embodiments, the actuating unit 130 for liquid dispensing apparatus 100 can be provided.Actuating unit 130 can
To be suitable to the first of accommodates plate 110 including at least two strong points 134 and actuating mechanism 132, the wherein at least two strong point 134
Surface, for supporting plate 110；Actuating mechanism 132 is suitable to deform plate 110, and the first surface of plate 110 is accommodated at least two
Make when on the strong point 134 plate 110 between at least two strong points 134 part deformation, with cause the end of plate 110 deflection with
The flow export of the end of movable plate 110.Actuating mechanism 132 can be adapted between at least two strong points 134 to plate
The relative second surface applying power of 110 first surface, so that the part deformation of the plate 110 between at least two strong points 134.
According to various embodiments, actuating unit 130 can be adapted to vertically to the second surface applying power of plate 110.
According to various embodiments, the plate 110 of liquid dispensing apparatus 100 can be provided for.Plate 110 can be included in its end
Flow export at portion.Flow export can be the form of nozzle.The first surface of plate 110 may be adapted to be contained in supporting plate 110
On at least two strong points 134.The first surface of plate 110 is accommodated at least two strong points 134, and plate 110 may be adapted to
Make the part deformation of the plate 110 between at least two strong points 134, to cause the deflection of the end of plate 110 to be flowed out with mobile
Mouthful.Plate 110 may be adapted to, by between at least two strong points 134 towards second table relative with the first surface of plate 110
Face apply power and make plate 110 between at least two strong points 134 part deformation.
According to various embodiments, a kind of method for liquid distribution can be provided.This method can include：Make plate 110
Part deformation between at least two strong points 134, to cause the deflection of the end of plate 110 with the end of movable plate 110
Flow export, wherein plate 110 are supported at least two strong points 134, and the first surface of plate 110 is accommodated at least two
On the strong point 134.Deforming the part of plate 110 can be included between at least two strong points 134 to first with plate 110
The relative second surface applying power in surface.
According to various embodiments, this method can also include plate 110 being placed at least two strong points 134.
According to various embodiments, at least two strong points 134 can be located at the actuating unit 130 of liquid dispensing apparatus 100
In one or more supporting constructions.Therefore, this method can also include the actuating unit 130 of operating liquid distributor 100, use
In between at least two strong points 134 towards the second surface applying power of plate 110.
Fig. 2 shows the schematic diagram of the basic operation of the liquid dispensing apparatus 200 according to various embodiments.As shown in Fig. 2
Liquid distribution can be realized by the vibration of the plastic plate 210 mechanically bent by power.Advantageously, plastic plate 210 can be with
Low cost manufacture.Plastic plate 210 can be attached simply to liquid dispensing apparatus 200, such as pass through the clamping based on magnet.Such as
Shown in Fig. 2, rectangular slab 210 can be supported along one end of longer side at two points 234.By being pointed to two supports
The plate 210 of the middle of part 234 enters row energization to realize that low energy activates, and can simply realize and put in the other end of plate 210
Big vibration.In fig. 2, the Oscillation Amplitude of the other end of plate 210 is represented by Δ D, and positioned at the centre of two support members 234
The excitation amplitude of the plate 210 at place is represented by Δ d.In fig. 2 it is shown that Δ D>>Δd.In other words, at the other end of plate 210
Vibration amplitude be more than plate 210 positioned at the middle of two support members 234 excitation amplitude.Therefore, by two
Row energization is entered in the centre of support member 234 towards the other end of plate 210 to plate 210, can be put in the end of rectangular slab 210
Big vibration.
Fig. 3 shows the schematic diagram of the liquid dispensing apparatus 300 according to various embodiments.Liquid dispensing apparatus 300 can be with
Encourage and control including electromagnet 342, permanent magnet 344, the rectangular plastic plate (that is, plate) 310 for being integrated with flow export 312 and electromagnet
System (that is, controller) 336.Flow export 312 can be nozzle.Electromagnet 342 and permanent magnet 344 can be liquid dispensing apparatus
A part for the actuating mechanism 332 of 300 actuating unit 330.
Rectangular plastic plate 310 can be thin plate, such as the thickness with about 1mm.Rectangle plastic board 310 can be located at
On the simple support part 334 of the top of electromagnet 342, such as at least two supports of the actuating unit 330 of liquid dispensing apparatus 300
Point.When electromagnet 342 is with the square wave of low frequency or sine wave quasi-periodic waveform stimulus, due to permanent magnet 344 and electromagnet 342
Between interaction, periodic power can be applied on the top of clamped plastic plate 310.This power can pass through through
The driving voltage of electromagnet 342 is controlled to set by electromagnet excitation control system 336.
As shown in figure 3, the excitation of the periodicity chucking power caused by the interaction of electromagnet 342 and permanent magnet 344
Plastic plate 310 may be caused to be forced to vibrate with the identical frequency of solenoid actuated signal 338.In the freedom of plastic plate 310
This vibration at end (end away from pinching end) place can pass through the laser vibrometer as shown in the sinusoidal waveform 314 in Fig. 3
System (that is, Polytec OFV-5000 vibrometers) is verified.The vibration of amplification can also be tested by simulation as shown in Figure 4
Card., can be from the flow export positioned at the free end of plastic plate 310 with the up and down motion of the amplification of the free end of plastic plate 310
312 distribution liquid.Multiple flow exports 312 can be arranged in the form of an array, to distribute multiply liquid flow or multiply discrete bodies simultaneously
Long-pending liquid or multiply drop.Because the vibration of plastic plate 310 can follow electromagnet pumping signal 338, it is possible to pass through electricity
Magnet pumping signal 338 drives liquid to distribute.
According to various embodiments as implied above, liquid distribution on demand can be realized by electromagnetic system.
Fig. 4 shows the analog result 401 of the vibration of the twisted plate 410 simply supported, to verify the freedom of twisted plate 410
The amplification at 416 is held to vibrate.As illustrated, the maximum displacement of the free end 416 of plate 410 is about 300 microns, and plate 410 is two
The displacement of the part 418 of individual simple support part middle can be less than 50 microns.Therefore, simulation results show plate 410 from
Vibrated by the amplification at end 416.
Fig. 5 shows what is produced and collect on planar substrates 508 by the liquid dispensing apparatus according to various embodiments
The photo 501 of the liquid array 506 accurately controlled.In order to obtain the liquid array 506 of shown accurate control, when liquid point
During the end portion vibration of the plate with device, planar substrates 508 can be manually moved.
According to various embodiments, Fig. 1 to Fig. 4 plate 110,210,310,410 can be made of plastics.Advantageously, liquid
Distribution chip (that is, plate) can be manufactured to disposable unit and be produced with low cost, because plate and flow export can be with
It is plastic molded component.Plate and flow export can be with integrally molded or separately fabricated.
According to various embodiments, Fig. 1 to Fig. 4 plastic plate 110,210,310,410 can by non-magnetic metal plate, such as
Copper coin, aluminium sheet or stainless steel plate substitute.Flow export can also be made up of other nonmagnetic substances, such as stainless steel.
According to various embodiments, multiple flow exports are desirably integrated into elastic plate.Multiple flow exports can be integrated so that more
The layout of individual flow export can limit the pattern for realizing patterning and printing.Therefore, can be by multiple flow exports come real
Existing high flux patterning and printing.For example, as shown in the plate 610 and 611 in Fig. 6 A and 6B.
According to various embodiments, identical effect can be produced in other motivational techniques of the intermediate application of two strong points
Fruit.For example, as shown in Figure 6B, the actuating of elastic plate 611 can replace solenoid actuated mechanism come real by rotating cam 690
It is existing.
Fig. 6 A show circular slab 610, and it has the flow export 612 that the circumference around circular slab 610 is set.Plectane 610
It can be supported by least two strong points 634.At least two strong points 634 can be located at the annular brace of support circular slab 610
In structure.Applying power may cause the end 616 of plate 610 to deflect on the part 618 of plate 610.Periodically it is applied to the portion of plate 610
The power divided on 618 may cause the end 616 of plate 610 to vibrate.Embodiment as shown in Figure 6A is to be integrated into multiple flow exports
The example of high pass quantity of fluid distribution/printing in elastic plate.
Fig. 6 B show rectangular slab 611, and it has the flow export 613 that the width across the end 617 of plate 611 arranges.Square
Shape plate 611 can be supported by least two strong points 635.At least two strong points 635 can be located at two separated supports respectively
In structure.When rotating cam rotation, rotation cam 690 can be periodically to the applying power of a part 619 of plate 611.The power can
The end 617 of plate 611 can be caused to deflect.The end of plate 611 may periodically be caused to applying power on the part 619 of plate 611
617 vibrations.Fig. 6 B are the examples of the high pass quantity of fluid distribution/printing activated by rotation cam on multiple flow export circuit boards.
According to various embodiments, the fluid dispensing system on demand (that is, liquid dispensing apparatus) including elastic plate can be provided.
Can elastic plate one end applying power so that plate deform, and elastic plate free end obtain amplification displacement.Liquid on demand
Body distribution system may also include control piece, to change the power for deforming elastic plate to obtain the controlled motion of the free end of plate.Press
Fluid dispensing system is needed to include being integrated into one or more of free end of elastic plate flow export.
According to various embodiments, elastic plate can be under simple support.
According to various embodiments, the elastic plate with flow export can be dismantled easily from the remainder of system.
According to various embodiments, the power being applied on one end of elastic plate can be by the way that plate is placed on into permanent magnet and electricity
Caused clamping force between magnet.
According to various embodiments, air gap (air gap) is there may be between elastic plate and electromagnet, to cause elastic plate
Deformed due to the electromagnetic force of application.
According to various embodiments, the clamping force of elastic plate can be applied to change using magnet control, so as to control
The movement of the distal end of elastic plate.
According to various embodiments, the actuating of elastic plate can be carried out by rotating cam.
According to various embodiments, when the extension of plate, the displacement of the distal end of elastic plate can be amplified.
According to various embodiments, elastic plate is simply sandwiched in using permanent magnet and electromagnet and can aid between the two
Elastic plate is easily dismantled from the remainder of system.
According to various embodiments, microfluidic channel can be integrated into elastic plate.
According to various embodiments, the flow export being integrated into elastic plate can be arranged in single with certain layout
Printed patterns under liquid distribution circulation.
Various embodiments can provide simple and inexpensive liquid dispensing apparatus and method, and it can be easy to quickly
Change the liquid distributing part contacted with liquid；The liquid distributing part (being contacted with liquid) of low cost；Caused with low energy machinery
Motivation structure.
The liquid distributing part of low cost may be disposable liquid distributing part, to avoid the dirt in liquid dispensing process
Dye.This can be realized, because various embodiments can allow liquid distributing part to be physically isolated with mechanical actuating member.
Simple liquid dispensing apparatus and method can also provide advantages below.For example, plastics twisted plate can be easy to
Ground disassembles from device or the remainder of system.The quick-replaceable of liquid distribution chip or plate can also be realized.Standard
Sterilizing methods can be used for preparing for biology or the liquid of medicinal application distribution chip.
In addition, liquid distribution can be realized by the vibration of the twisted plate by solenoid actuated system drive.Therefore, liquid
Body assignment interval can simply be controlled by solenoid actuated signal.Therefore, various embodiments can provide the liquid point of precision
With device.
In addition, the vibration installed in the flow export of the far-end of twisted plate may (may be in permanent magnet than in Clamping Center
Position) place plate benging displacement it is much bigger because the enlarge-effect of the cantilever-shaped support of twisted plate.
Advantageously, various embodiments can be used for many engineerings and scientific application, such as unicellular printing, protein and DNA
Deposition on diagnosis bar of microarray, reagent, drug screening etc..The concept of the disposable chip or plate of low cost may fit very much
Close needs compared with the medicine of of low pollution and biochemical printing (that is, biological micro-array prints) in process of production.Other application can be
Picture on surface for the functional material of OTFT, Organic Light Emitting Diode, organic solar batteries, sensor etc.
Change.
Although the present invention is specifically illustrated and described by reference to specific embodiment, those skilled in the art should manage
Solution, in the case where not departing from the scope of the present invention being defined by the following claims, can carry out form and details wherein
On various changes.Therefore, the scope of the present invention is represented by appended claims, and is therefore incorporated into claim
All changes in the implication and scope of equivalent are all.
Claims (20)
1. a kind of liquid dispensing apparatus, including：
Plate, the end of the plate have flow export；And
Actuating unit, including：
For supporting at least two strong points of the plate, wherein the first surface of the plate is accommodated in described at least two
In support point；With
Actuating mechanism, it is suitable to the part deformation for making the plate between at least two strong point, so that the institute of the plate
End deflection is stated with the movement flow export.
2. device according to claim 1, wherein the actuating mechanism is further adapted for, make the plate described at least two
Deform the part periodic between the individual strong point, the flow export is shaken so as to produce vibration in the end of the plate
Swing.
3. device according to claim 1, wherein the actuating mechanism is further adapted for making the plate in response to pumping signal
Deformation.
4. device according to claim 3, wherein the pumping signal includes cyclical signal or pulse signal.
5. device according to claim 1 or 2, wherein the actuating mechanism is further adapted for, at least two strong point
Between to the second surface applying power relative with the first surface of the plate so that the plate is in described at least two supports
Part deformation between point.
6. device according to claim 5, wherein the actuating mechanism includes rotary cam structure.
7. device according to claim 6, wherein the rotary cam structure includes rotation cam, the rotation cam is fitted
In the second surface for directly contacting the plate, the power is applied directly on the second surface of the plate.
8. device according to claim 5, wherein the actuating mechanism includes solenoid actuated mechanism.
9. device according to claim 8, wherein, the solenoid actuated mechanism includes：
Electromagnet；With
Permanent magnet, it can may move separately and relative to the electromagnet with the electromagnet,
Wherein, the electromagnet is arranged between at least two strong point and supported towards being contained in described at least two
The first surface of the plate on point, and the permanent magnet is arranged to the second surface towards the plate；And
Wherein, the electromagnet is operable magnetically to attract permanent magnet, for making the permanent magnet relatively toward the electricity
Magnet moves, to cause the permanent magnet to the second surface applying power of the plate between at least two strong point, to use
Deformed in making the part of the plate between at least two strong point.
10. device according to claim 8 or claim 9, wherein, the actuating mechanism also includes being suitable to control based on pumping signal
The controller of the operation of the solenoid actuated mechanism.
11. device according to any one of claim 1 to 10, wherein, at least two strong point is suitable to detachable
Ground accommodates the plate.
12. the device according to any one of claim 1 to 11, wherein, the flow export is integrally formed with the plate.
13. the device according to any one of claim 1 to 12, wherein, the plate includes connecting with the flow export fluid
The microfluidic channel connect.
14. device according to claim 13, in addition to suitable for supplying the fluid supply of liquid to the microfluidic channel.
15. the device according to any one of claim 1 to 14, wherein, the end of the plate be connected it is described extremely
The distance between midpoint of line of few two strong points be more than any one and the midpoint at least two strong point it
Between twice of distance.
16. the device according to any one of claim 1 to 15, wherein at least two strong point includes being located at respectively
At least two points in the separated supporting construction points opened.
17. the device according to any one of claim 1 to 15, wherein at least two strong point includes being located at one
At least two points in the supporting construction points opened.
18. a kind of actuating unit for liquid dispensing apparatus, the actuating unit includes：
At least two strong points, suitable for the first surface of accommodates plate, for supporting the plate, and
Actuating mechanism, suitable for making the plate that the first surface is contained at least two strong point in the institute of the plate
The part deformation between at least two strong points is stated, to cause the deflection of the end of the plate with mobile in the end of the plate
Flow export.
19. a kind of plate for liquid dispensing apparatus, the plate includes：
Flow export in the end of the plate,
Wherein, the first surface of the plate is suitable to be accommodated at least two strong points for supporting the plate, and
Wherein, the plate that the first surface is contained at least two strong point is suitable to, make the plate it is described extremely
Part deformation between few two strong points, so that the end of the plate is deflected with the movement flow export.
20. a kind of method for liquid distribution, methods described includes：
Make part deformation of the plate between at least two strong points, to cause the deflection of the end of the plate with mobile described
The flow export of the end of plate, wherein, the plate is supported at least two strong point, the first table of the plate
Face is contained at least two strong point.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201501869Q | 2015-03-11 | ||
| SG10201501869Q | 2015-03-11 | ||
| PCT/SG2016/050109 WO2016144262A1 (en) | 2015-03-11 | 2016-03-08 | Apparatus and method for liquid dispensing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107530701A true CN107530701A (en) | 2018-01-02 |
Family
ID=56880472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680027425.9A Pending CN107530701A (en) | 2015-03-11 | 2016-03-08 | For liquid assigned unit and method |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN107530701A (en) |
| SG (1) | SG11201707353VA (en) |
| WO (1) | WO2016144262A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2779623A (en) * | 1954-09-10 | 1957-01-29 | Bernard J Eisenkraft | Electromechanical atomizer |
| JPH09165030A (en) * | 1996-11-22 | 1997-06-24 | Kureha Chem Ind Co Ltd | Sheet-dispensing case |
| US6629646B1 (en) * | 1991-04-24 | 2003-10-07 | Aerogen, Inc. | Droplet ejector with oscillating tapered aperture |
| CN101284639A (en) * | 2007-05-07 | 2008-10-15 | 马雷克·希曼斯基 | Liquid dispensing apparatus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2505423A (en) * | 1948-01-22 | 1950-04-25 | Morgan Henry Walter | Magnetic drink mixer |
| US2646261A (en) * | 1950-06-23 | 1953-07-21 | Eugene M Poirot | Device which aerates water |
| US4336544A (en) * | 1980-08-18 | 1982-06-22 | Hewlett-Packard Company | Method and apparatus for drop-on-demand ink jet printing |
| JP5487638B2 (en) * | 2009-02-17 | 2014-05-07 | ソニー株式会社 | Apparatus for microparticle sorting and microchip |
-
2016
- 2016-03-08 CN CN201680027425.9A patent/CN107530701A/en active Pending
- 2016-03-08 WO PCT/SG2016/050109 patent/WO2016144262A1/en active Application Filing
- 2016-03-08 SG SG11201707353VA patent/SG11201707353VA/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2779623A (en) * | 1954-09-10 | 1957-01-29 | Bernard J Eisenkraft | Electromechanical atomizer |
| US6629646B1 (en) * | 1991-04-24 | 2003-10-07 | Aerogen, Inc. | Droplet ejector with oscillating tapered aperture |
| JPH09165030A (en) * | 1996-11-22 | 1997-06-24 | Kureha Chem Ind Co Ltd | Sheet-dispensing case |
| CN101284639A (en) * | 2007-05-07 | 2008-10-15 | 马雷克·希曼斯基 | Liquid dispensing apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016144262A1 (en) | 2016-09-15 |
| SG11201707353VA (en) | 2017-10-30 |
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Application publication date: 20180102 |