CN107519958A - A kind of Microfluidic droplet generating means and its application - Google Patents
A kind of Microfluidic droplet generating means and its application Download PDFInfo
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- CN107519958A CN107519958A CN201710466185.9A CN201710466185A CN107519958A CN 107519958 A CN107519958 A CN 107519958A CN 201710466185 A CN201710466185 A CN 201710466185A CN 107519958 A CN107519958 A CN 107519958A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
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Abstract
The present invention relates to a kind of Microfluidic droplet generating means, including：One glass substrate, at least one first chip and one second chip, first chip and second chip be may be contained within the glass substrate, also, first chip is connected with second chip by a connecting pipe；Wherein, first chip is microchannel chip, has in one continuous phase entrance in dispersed phase entrance and one；Second chip is capillary chip, has an outer continuous phase entrance.The three-dimensional structure and rational pipe-line transportation system that the Microfluidic droplet generating means of the present invention have had, are easy to make, overcome classical production process because of the technical problem of high cost and low reliability caused by manufacturing process complexity.
Description
Technical field
The present invention relates to a kind of microfluidic art, more particularly to a kind of Microfluidic droplet generating means.
Background technology
Microflow control technique is a kind of technology for accurately being controlled and being manipulated minute yardstick fluid using micro-meter scale microchannel.Utilize
Micro fluidic device, the microemulsion droplets of size uniform can be formed, and microflow control technique possesses accurate control drop size, knot
The ability of structure and shape.Double emulsion drop with double-deck core shell structure is widely used in pharmacy, biology, Food Science
Also it is widely used Deng the research in field, while in industrial quarters.
The preparation of double emulsion drop at present mainly uses capillary micro fluidic device, but capillary glass tube device is to device
The required precision of assembling is high, and all capillaries must assure that coaxial state, and capillary tip size needs between 20-150 μm
Special drawing needle apparatus is used to make, cost and defect ware rate are high.And for based on polydimethyl siloxane material
Micro-fluidic chip, will prepare double emulsion drop, and a kind of method is needed between fluid channel intersection of the size less than 200_ μm
The isolation of runner both sides inwall hydrophilic and hydrophobic is realized, but the surface wettability control of fluid channel part is still a challenge；Separately
A kind of method is to use three-dimensional nonplanar structure, but the processing cost and difficulty of nonplanar structure template are all very high.
Therefore, it is necessary to which a kind of new micro flow control chip device prepares double emulsion drop, both can efficiently and rapidly prepare
Micro-fluidic chip, and can effectively avoid the low reliability that the manufacturing process due to complexity is brought, so as to reduce cost of manufacture and make
Use cost.
The content of the invention
Present invention seek to address that above mentioned problem, and it is an object of the invention to provide a kind of Microfluidic droplet generates
Device, once emulsification and the second emulsifying process of drop formation process are respectively in the microchannel chip of the first order and the hair of the second level
Completed on tubule chip, by adjusting driving pressure, generate controllable double emulsion drop.
To achieve these goals, the present invention provides a kind of Microfluidic droplet generating means, including：One glass substrate, extremely
Few one first chip and one second chip, first chip and second chip may be contained within the glass substrate,
Also, first chip is connected with second chip by a connecting pipe；Wherein, first chip is fluid channel core
Piece, there is in one continuous phase entrance in dispersed phase entrance and one；Second chip is capillary chip, has an outer continuous phase
Entrance.
In an embodiment of the present invention, the microchannel chip is formed by a miniflow channel layer and substrate layer fitting；Wherein,
There is at least one formed with an at least microchannel, the microchannel on surface of the fluid channel aspect to the substrate layer
Flow tube road and a linear pipeline, the branch flow pipe have a joint with the linear tube road；Also, the branch flow pipe leads to
One first pipeline is crossed to fluidly connect with the middle continuous phase entrance, one end of the linear pipeline by one second pipeline with it is described
Interior dispersed phase entrance fluidly connects and the other end fluidly connects with the outlet of one first double emulsion.
In an embodiment of the present invention, the branch flow pipe is half arc shape pipeline or a rectilinear duct.
In an embodiment of the present invention, when the branch flow pipe is a rectilinear duct, the branch flow pipe and the line
Angle between shape pipeline is 60~90 °.
In an embodiment of the present invention, the rectangular cross-section of the microchannel.
In an embodiment of the present invention, the capillary chip includes an internal layer capillary and an outer capillary tube；Wherein,
The internal layer capillary is nested in the outer capillary tube, and one end of the internal layer capillary exceeds the outer layer capillary
The mouth of pipe of pipe and export with first double emulsion and fluidly connected by the connecting pipe, and the internal layer capillary is another
End is then in the outer capillary tube；The outer capillary tube is close to the one of the internal layer capillary and the connecting pipe
End is provided with the outer continuous phase entrance, also, the outer capillary tube is away from the internal layer capillary and the connecting tube
Fluidly connected on the one end in road with the outlet of one second double emulsion.
In an embodiment of the present invention, a sealing is provided with the junction of the internal layer capillary and the connecting pipe
Block.
In an embodiment of the present invention, the capillary chip is sealed using epoxy resin.
In an embodiment of the present invention, first chip is made up of dimethyl silicone polymer.
In an embodiment of the present invention, the internal layer capillary and outer capillary tube are made by glass.
The present invention also provides application of the above-mentioned Microfluidic droplet generating means in double emulsion drop is prepared.
In an embodiment of the present invention, the microchannel chip for example, by but be not limited to following methods and be made：With wet method
The mould of the microchannel is made in optical etching technology, and polydimethyl siloxane material is then poured on mould, is taken off after cured
Mould, obtain the miniflow channel layer of microchannel chip.Using ionic bonding technology, miniflow channel layer is bonded on substrate layer, you can obtain
Obtain microchannel chip.Wherein, the polydimethyl siloxane material by polydimethylsiloxane prepolymer thing and curing agent by (9~
12)：1 mass ratio mixes；Especially when polydimethylsiloxane prepolymer thing and curing agent mass ratio are 10:Effect is most when 1
It is good.
In an embodiment of the present invention, the internal layer capillary is arranged at the sealing block that the connecting pipe is connected to pass through
Such as, but not limited to following methods are made：First, one end of the internal layer capillary is connected with the connecting pipe, then will
The other end of the internal layer capillary is inserted in the outer capillary tube；Then, internal layer capillary described in epoxy resin sealing is utilized
The junction between junction and the internal layer capillary and the outer capillary tube between pipe and the connecting pipe；With
Afterwards, then by the polymethyl methacrylate of prior internal hollow out the company being placed between the internal layer capillary and the connecting pipe
Connect junction between place and the internal layer capillary and the outer capillary tube (i.e. so that the hollow out internal in advance
Polymethyl methacrylate accommodates junction and the internal layer between the internal layer capillary and the connecting pipe simultaneously
Junction between capillary and the outer capillary tube), and filled and closed with epoxy resin, form the sealing block structure.
It should be noted that Microfluidic droplet generating means of the present invention using when must not should be noted that be passed through may be molten
Solve the solvent of epoxide resin material.
The Microfluidic droplet generating means of the present invention are simple in construction, can effectively avoid the manufacturing process due to complexity from bringing
Low reliability, not only have efficiently it is quick but also inexpensive the characteristics of.The present invention Microfluidic droplet generating means had three
Structure and rational pipe-line transportation system are tieed up, is easy to make, overcomes classical production process because caused by manufacturing process complexity
The technical problem of high cost and low reliability.
Brief description of the drawings
By the following detailed description and appended accompanying drawing, above-mentioned and other object of the invention, feature and advantage will be aobvious
And be clear to, wherein：
Fig. 1 is the structural representation of Microfluidic droplet generating means of the present invention；
Fig. 2 is the structural representation of the miniflow channel layer of microchannel chip described in Fig. 1；
Fig. 3 is the structural representation of capillary chip described in Fig. 1；
Fig. 4 is that (scale is the W/O/W bilayer drop for preparing of the Microfluidic droplet generating means that prepare of the present invention
1000 microns)；
Fig. 5 is another structural representation of the miniflow channel layer of microchannel chip described in Fig. 1.
Embodiment
Hereinafter, by refer to the attached drawing, some exemplary embodiments of the present invention are described.In the following description, no
Identical label will be marked by with the similar elements shown in accompanying drawing.In addition, in description of the invention below, when this can be caused
When the theme of invention is not known, it will omit the detailed description for the known function contained by this paper and construction.
In addition, when the component of the description present invention, such as first, second, A, B, (a), (b) etc may be used herein
Term.These terms without in define a corresponding assembly essence, order or sequence, and be used only for distinguish corresponding assembly with
Other assemblies.It should be noted that a component described in the specification is " connection ", " coupling " or " addition " to another
Component, " it can also connect " in the first and second inter-modules, " coupling " or " addition " one the 3rd component, although the first assembly
It is probably to be connected directly, couple or add second component.
Fig. 1 is the structural representation of Microfluidic droplet generating means of the present invention, the miniflow of microchannel chip described in Fig. 2
The structural representation of channel layer；Fig. 3 is the structural representation of the capillary chip.
As shown in Figure 1, in the present embodiment, there is provided a kind of Microfluidic droplet generating means 10, including：One glass substrate
13rd, at least one first chip 11 and one second chip 12.First chip 11 and second chip 13 may be contained within described
On glass substrate 13, also, first chip 11 is connected with second chip 12 by a connecting pipe 14.Described
One chip 11 is microchannel chip, has in one continuous phase entrance 101 in dispersed phase entrance 102 and one；Second chip 12
For capillary chip, there is an outer continuous phase entrance 103.
Hereinafter, the microchannel chip of first chip 11 is described in detail with reference to Fig. 1 and Fig. 2.
The microchannel chip is formed by a miniflow channel layer 113 and substrate layer (not shown) fitting.As shown in Figure 2
, formed with an at least microchannel on surface of the miniflow channel layer 113 in face of the substrate layer.The section of the microchannel
For rectangle.
As depicted, in the present embodiment, the completely the same microchannel of two shapes is formed.The microchannel has one
112 and one linear pipeline 114 of semicircular arc pipeline, the semicircular arc pipeline 112 have one to cross with the linear pipeline 114
Point.The semicircular arc pipeline 112 is fluidly connected by one first pipeline 115 and the middle continuous phase entrance 101, described linear
One end of pipeline 114 is fluidly connected multiple and the other end and one first by one second pipeline 116 with the interior dispersed phase entrance 102
Emulsion outlet 117 fluidly connects.
In the present embodiment, the microchannel chip of first chip 11 for example, by but be not limited to following methods and be made：
The mould of the microchannel is made with wet method optical etching technology, polydimethyl siloxane material is then poured on mould, treats solid
It is stripped after change, obtains the miniflow channel layer of microchannel chip.Using ionic bonding technology, microchannel layers are bonded on substrate layer,
Microchannel micro-fluidic chip can be obtained.Wherein, the polydimethyl siloxane material by polydimethylsiloxane prepolymer thing with
Curing agent presses (9~12)：1 mass ratio mixes；Especially when polydimethylsiloxane prepolymer thing and curing agent mass ratio are
10:Best results when 1.
Certainly, please with further reference to Fig. 5, as shown in Figure 5, the microchannel has two Hes of straight line branch flow pipe 111
One linear pipeline 114, the straight line branch flow pipe 111 have a joint with the linear pipeline 114, are formed as shown in Figure 5
Similar Y shape microchannel.Likewise, the straight line branch flow pipe 111 passes through one first pipeline 115 and the middle continuous phase entrance
101 are fluidly connected, and one end of the linear pipeline 114 is connected by one second pipeline 116 and the interior fluid of dispersed phase entrance 102
Connect and the other end and one first double emulsion outlet 117 fluidly connects.The straight line branch flow pipe 111 and the linear pipeline 114
Between angle α be 60~90 °.
Hereinafter, the capillary chip of second chip 12 is described in detail with reference to Fig. 1 and Fig. 3.
As depicted, the capillary chip includes an internal layer capillary 122 and an outer capillary tube 123.As schemed
Show, the internal layer capillary 122 is nested in the outer capillary tube 123, and one end of the internal layer capillary 122 surpasses
Go out the mouth of pipe of the outer capillary tube 123 and export with first double emulsion and fluidly connected by the connecting pipe 14.And
The other end of the internal layer capillary 122 is then in the outer capillary tube 123.The outer capillary tube 123 is close to institute
State internal layer capillary 122 and be provided with the outer continuous phase entrance 103 with (i.e. left end in figure) on one end of the connecting pipe 14.Institute
State outer capillary tube 123 on one end away from the internal layer capillary 122 and the connecting pipe 14 (i.e. right-hand member in figure) and
One second double emulsion outlet 104 fluidly connects.
As shown in Figure 3, it is provided with a sealing block in the junction of the internal layer capillary 122 and the connecting pipe 14
121.What the sealing block 121 was formed by：First, internal layer capillary 122 described in epoxy resin sealing and the company are utilized
The junction in adapter road 14；Then, then by the polymethyl methacrylate of prior internal hollow out it is placed in the internal layer capillary 122
With the junction of the outer capillary tube 123, and with epoxy resin fill close, form the structure of sealing block 121 as depicted.
The capillary chip is sealed using epoxy resin.
In order to verify that Microfluidic droplet generating means of the present invention prepare the feasibility of double emulsion drop, applicant couple
Device 10 in Fig. 1 has carried out experimental verification：The liquid generated needed for drop is driven by micro-injection pump, respectively by interior point
In dephasing entrance 102, middle continuous phase entrance 101 and the injection device 10 of foreign minister's entrance 103, interior phase and middle phase fluid are in such as Fig. 2 institutes
One-level drop is generated in the microchannel chip 11 shown, and emulsifies the hair of coaxial configuration in two level as shown in Figure 3 with external fluid phase
Form multiple parcel in tubule chip 12, generation double emulsion drop simultaneously via the output of second double emulsion outlet 104, obtain as
Drop shown in Fig. 4.It can be seen that it can ensure that obtained drop has core using Microfluidic droplet generating means of the present invention
Shell structure.
The Microfluidic droplet generating means of the present invention are simple in construction, can effectively avoid the manufacturing process due to complexity from bringing
Low reliability, not only have efficiently it is quick but also inexpensive the characteristics of.The present invention Microfluidic droplet generating means had three
Structure and rational pipe-line transportation system are tieed up, is easy to make, overcomes classical production process because caused by manufacturing process complexity
The technical problem of high cost and low reliability.
Even if described above, the component of one embodiment of the invention is combined into a single unit or is used as a single list
Atom operation, the present invention are not necessarily limited to an embodiment.That is, in each component, one or more assemblies can be chosen
Combine to selecting property, to be used as one or more units.Although describe the present invention for illustrative purposes one preferably implements
Example, it will be appreciated by those skilled in the art that not departing from the scope and spirit of the present invention as disclosed in appended claims
Under, a variety of modifications, addition or replacement are feasible.The scope of the present invention should be on the basis of appended claims, with a kind of institute
The mode that technical thought is included in the scope suitable with the claim for belonging to the present invention is stated to explain.
Claims (10)
1. a kind of Microfluidic droplet generating means, including：One glass substrate, at least one first chip and one second chip, it is described
First chip and second chip may be contained within the glass substrate, also, first chip and second core
Piece is connected by a connecting pipe；Wherein,
First chip is microchannel chip, has in one continuous phase entrance in dispersed phase entrance and one；
Second chip is capillary chip, has an outer continuous phase entrance.
2. Microfluidic droplet generating means as claimed in claim 1, it is characterised in that the microchannel chip is by a fluid channel
Layer and substrate layer fitting form；Wherein, it is micro- formed with least one on surface of the fluid channel aspect to the substrate layer
Pipeline, the microchannel have an at least branch flow pipe and a linear pipeline, and the branch flow pipe has with the linear tube road
One joint；Also, the branch flow pipe is fluidly connected by one first pipeline and the middle continuous phase entrance, the linear tube
The one end in road is fluidly connected by one second pipeline and the interior dispersed phase entrance flows and the other end and the outlet of one first double emulsion
Body connects.
3. Microfluidic droplet generating means as claimed in claim 2, it is characterised in that the branch flow pipe is a semicircular arc
Pipeline or a rectilinear duct.
4. Microfluidic droplet generating means as claimed in claim 3, it is characterised in that when the branch flow pipe is a rectilinear tubes
During road, the angle between the branch flow pipe and the linear pipeline is 60~90 °.
5. Microfluidic droplet generating means as claimed in claim 2, it is characterised in that the rectangular cross-section of the microchannel.
6. Microfluidic droplet generating means as claimed in claim 2, it is characterised in that the capillary chip includes an internal layer
Capillary and an outer capillary tube；Wherein, the internal layer capillary is nested in the outer capillary tube, and the internal layer hair
One end of tubule passes through the connecting pipe fluid beyond the mouth of pipe of the outer capillary tube with first double emulsion outlet
Connection, and the other end of the internal layer capillary is then located in the outer capillary tube；The outer capillary tube is close to described
One end of internal layer capillary and the connecting pipe is provided with the outer continuous phase entrance, also, the outer capillary tube is remote
From the internal layer capillary with being fluidly connected on one end of the connecting pipe with the outlet of one second double emulsion.
7. Microfluidic droplet generating means as claimed in claim 6, it is characterised in that in the internal layer capillary and the company
The junction in adapter road is provided with a sealing block.
8. Microfluidic droplet generating means as claimed in claim 6, it is characterised in that seal the capillary using epoxy resin
Die.
9. the Microfluidic droplet generating means as any one of claim 1 to 8, it is characterised in that first chip
It is made up of dimethyl silicone polymer；The internal layer capillary and outer capillary tube are made by glass；The connecting pipe is by gathering
Tetrafluoroethene is made.
10. application of the Microfluidic droplet generating means as claimed in claim 1 in double emulsion drop is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710466185.9A CN107519958A (en) | 2017-06-19 | 2017-06-19 | A kind of Microfluidic droplet generating means and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710466185.9A CN107519958A (en) | 2017-06-19 | 2017-06-19 | A kind of Microfluidic droplet generating means and its application |
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| Publication Number | Publication Date |
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| CN107519958A true CN107519958A (en) | 2017-12-29 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108273576A (en) * | 2018-03-12 | 2018-07-13 | 苏州锐讯生物科技有限公司 | The micro-fluidic chip system that adjustable lotion is formed |
| CN108544748A (en) * | 2018-02-02 | 2018-09-18 | 天津大学 | A method of building non-sub- drop type labyrinth in drop |
| CN108636464A (en) * | 2018-04-02 | 2018-10-12 | 中国科学院苏州生物医学工程技术研究所 | A kind of drop micro-fluidic chip, molding machine and preparation method thereof |
| CN109351369A (en) * | 2018-10-23 | 2019-02-19 | 深圳市博瑞生物科技有限公司 | Microfluidic droplet generates chip |
| CN109351368A (en) * | 2018-10-23 | 2019-02-19 | 深圳市博瑞生物科技有限公司 | Micro-fluidic chip |
| CN110394203A (en) * | 2019-08-08 | 2019-11-01 | 北京理工大学 | It is a kind of can repeated disassembled and assembled and replacement component compound microlayer model generating means |
| CN110575851A (en) * | 2018-06-07 | 2019-12-17 | 洛阳华清天木生物科技有限公司 | Device and chip for micro-droplet quantitative segmentation and fusion and micro-droplet quantitative segmentation and fusion method |
| CN110665555A (en) * | 2019-09-30 | 2020-01-10 | 大连理工大学 | Coaxial capillary microfluidic chip and preparation method thereof |
| CN116899078A (en) * | 2023-09-14 | 2023-10-20 | 深圳先进技术研究院 | Magnetic drive micrometer guide wire capable of being programmed repeatedly and manufacturing method thereof |
-
2017
- 2017-06-19 CN CN201710466185.9A patent/CN107519958A/en active Pending
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| HUANG CONG ET AL: "Controllable Gas in oil in water double emulsion formation in a non-planar microfluidic device", 《HTTP://SPIEDIGITALLIBRARY》 * |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108544748A (en) * | 2018-02-02 | 2018-09-18 | 天津大学 | A method of building non-sub- drop type labyrinth in drop |
| CN108544748B (en) * | 2018-02-02 | 2020-01-31 | 天津大学 | method for constructing non-sub-droplet type complex structure in droplet |
| CN108273576A (en) * | 2018-03-12 | 2018-07-13 | 苏州锐讯生物科技有限公司 | The micro-fluidic chip system that adjustable lotion is formed |
| CN108636464A (en) * | 2018-04-02 | 2018-10-12 | 中国科学院苏州生物医学工程技术研究所 | A kind of drop micro-fluidic chip, molding machine and preparation method thereof |
| CN110575851A (en) * | 2018-06-07 | 2019-12-17 | 洛阳华清天木生物科技有限公司 | Device and chip for micro-droplet quantitative segmentation and fusion and micro-droplet quantitative segmentation and fusion method |
| CN110575851B (en) * | 2018-06-07 | 2024-05-24 | 洛阳华清天木生物科技有限公司 | Device for quantitatively dividing and fusing micro-droplets, chip and quantitatively dividing and fusing method of micro-droplets |
| CN109351369A (en) * | 2018-10-23 | 2019-02-19 | 深圳市博瑞生物科技有限公司 | Microfluidic droplet generates chip |
| CN109351369B (en) * | 2018-10-23 | 2021-01-26 | 深圳市博瑞生物科技有限公司 | Microfluidic droplet generation chip |
| CN109351368B (en) * | 2018-10-23 | 2021-04-30 | 深圳市博瑞生物科技有限公司 | Micro-fluidic chip |
| CN109351368A (en) * | 2018-10-23 | 2019-02-19 | 深圳市博瑞生物科技有限公司 | Micro-fluidic chip |
| CN110394203A (en) * | 2019-08-08 | 2019-11-01 | 北京理工大学 | It is a kind of can repeated disassembled and assembled and replacement component compound microlayer model generating means |
| CN110665555A (en) * | 2019-09-30 | 2020-01-10 | 大连理工大学 | Coaxial capillary microfluidic chip and preparation method thereof |
| CN116899078A (en) * | 2023-09-14 | 2023-10-20 | 深圳先进技术研究院 | Magnetic drive micrometer guide wire capable of being programmed repeatedly and manufacturing method thereof |
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