CN107518876A - Exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed - Google Patents
Exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed Download PDFInfo
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- CN107518876A CN107518876A CN201710599964.6A CN201710599964A CN107518876A CN 107518876 A CN107518876 A CN 107518876A CN 201710599964 A CN201710599964 A CN 201710599964A CN 107518876 A CN107518876 A CN 107518876A
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- 238000012014 optical coherence tomography Methods 0.000 title claims abstract description 46
- 238000003384 imaging method Methods 0.000 claims abstract description 67
- 239000000523 sample Substances 0.000 claims abstract description 34
- 239000013307 optical fiber Substances 0.000 claims abstract description 16
- 238000011049 filling Methods 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 abstract description 10
- 239000012535 impurity Substances 0.000 abstract description 3
- 238000011017 operating method Methods 0.000 abstract description 3
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 239000012634 fragment Substances 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 239000010408 film Substances 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000011010 flushing procedure Methods 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000005266 casting Methods 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000010068 moulding (rubber) Methods 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 208000004434 Calcinosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 238000001723 curing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000008376 long-term health Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012788 optical film Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endoscopes (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of all-sealed micro-optical coherence tomography OCT image conduit exempted and rinsed, including catheter core and the outer tube being set in outside catheter core, the catheter core includes optical fiber and fibre-optical probe, fibre-optical probe is located at the distal end of the imaging catheter, the fibre-optical probe includes miniature imaging lens, the exit of the miniature imaging lens is coated with optics antireflecting film, distal end with fibre-optical probe is provided with isolating seal portion by guiding seal wire to enter in measured body, in outer inside pipe casing and between fibre-optical probe and guide seal wire entrance.It is of the invention thoroughly exempt to remove rinse OCT image catheter interior this conventional OCT image operating procedure, improve the accuracy of imaging results, shorten Diagnostic Time, reduce patient's pain;And also reduce the use of contrast agent, it is entirely avoided caused any possible impurity fragment enters tissue during image scanning, not only reduces diagnosis cost, reduces risks, be advantageous to the health of patient.
Description
Technical field
The present invention relates to technical field of medical instruments, more particularly to a kind of all-sealed micro-optical rinsed of exempting to be concerned with
Tomography OCT image conduit.
Background technology
Optical coherence tomography OCT is a kind of high-resolution (10 micron order) angio-architecture imaging technique.In intracardiac OCT
(IV-OCT) in, conduit is inserted into artery to obtain 10 microns of resolution ratio section and 3-D view, makes arterial blood tube wall detailed
The visualization of micro-structural feature be possibly realized.Intracardiac OCT, which has been proved to be able to distinguish, includes the presence of lipid, inflammation,
The various relevant Clinical symptoms such as calcification, grumeleuse (thrombus).OCT can effectively describe blood vessel in these information that three dimensions is caught
The degree and type of lesion, so as to be used to Guided Interventional Treatment program as significant data.Other OCT also can be used in being imaged
Not yet cause the vascular lesion of thrombus.It is a kind of promising to treat the lesion before these coronary vasodilator lesions occur, and is used for
Improve the concept of CAD incidence and mortalities.
The general principle of spy imaging catheter is among the optical fiber with imaging probe is placed on medical sleeve pipe, into people
Coelomoduct, the light source in imaging device are irradiated in tissue by fibre-optical probe, and the scattering light for then detecting tissue is carried out
Imaging.Because the inside and outside wall of medical sleeve pipe is just between fibre-optical probe and tested person's body cavity tubing, they are micro- with optical fiber
Lens surface forms a multiple reflections chamber to imaging beam, has a strong impact on imaging effect of the light beam to tissue.Business at present
The scheme for solving this problem with cardiovascular OCT image conduit is relied on toward conduit inner core injection contrast agent or physiological saline, this
The optical refractive index and optical fibre microlens of a little contrast agent/salt solution are very close, therefore equivalent in fibre-optical probe and medical set
Refractive index matched liquid is filled between inside pipe wall, so as to effectively eliminate the reflection cavity between casing wall and fibre-optical probe
In the presence of ensure that imaging effect.The step for be referred to as purge irrigating catheters, be current commercial intracardiac IV-OCT standard operation
One of step.
Fig. 1 is the typical structure of the consumptive material imaging catheter of the commercial cardiovascular OCT equipment of current main flow, including catheter core 10 '
With outer tube 20 '.Except connecting the near-end of equipment and entering the distal end of human body, it also has an independent flushing liquor entrance 30 '.Doctor
It is raw when imaging catheter is prepared, it is necessary to from this flushing liquor entrance injection contrast agent, catheter center's chamber is rinsed, allows conduit
Contrast agent is full of inside outer tube.
Fig. 2 and Fig. 3 is the distal end detailed schematic of existing commercial imaging catheter.Catheter core 10 ' includes optical fiber 11 ' and optical fiber
Probe 12 '.Imaging catheter is sent to the distal end of lesion along seal wire D ', at least ensures that more than lesion distal end 5mm to be exceeded, then,
OCT host devices control unit control imaging catheter rotates back to automatically removes scanning, and it is whole to obtain a more visible vessel inner lesion
The imaging of body, so as to analyze lesion situation according to image.Rinsing imaging catheter causes imaging catheter to be full of contrast agent 50 '
The step for, first is to play a part of adding optical match liquid to fibre-optical probe, and second is after preventing conduit intravasation,
Blood enters the tube chamber of imaging catheter distal end, so as to influence the effect of imaging.
It must be noted that existing commercial imaging catheter is as shown in figure 3, it is not appropriate for plating disappears anti-film.Main cause is
The optical fiber GRIN Lens of existing commercial imaging catheter and the optics UV rubber mouldings casting 13 ' to transmission of the optical fiber prism 12 ' of grinding
Torque spring 60 ' on, the cylinder of light from molding body projects, and the cylinder is one section of transparent heat-shrink tube, fills UV rubber mouldings in it
Casting.
Although irrigating catheter inner core efficiently solves tube wall reflection problems, irrigating catheter inner core is except to doctor
Increase an operating procedure, also bring two obvious negative effects:Since it is desired that rinsing, distal end of catheter can not seal, so
The contrast agent of inner core is rinsed, together with the impurity of catheter interior caused by image scanning high speed rotary motion, including joint glue
Fragment caused by may failing is connect, is all directly entered patient blood, serious harm is produced to patient;Second, since it is desired that rinse,
Distal end of catheter can not seal, and the minute surface into fibre-optical probe during tube chamber is very easy to be contaminated by the blood, and is rushed every time with contrast solution
The effect washed is inconsistent, causes image quality cannot be guaranteed, doctor can do morely and withdraw imaging several times every time, to obtain a width
The image of quality satisfaction, not only extend operating time, increase patient's pain, and cause more contrast agent to enter human body, endanger
The health of patient;Third, contrast solution is very sticky, conduit is tiny, and contrast solution is squeezed into conduit is not easy to, it usually needs uses double
Hand operating syringe, also to open OCT systems and confirm to rinse enough, imaging clearly, it usually needs be repeated several times, during due to operation
Doctor needs to operate many equipment, and the program of irrigating catheter increases very big trouble to operation.
The content of the invention
It is an object of the invention to design and produce one can altogether dispense with irrigating catheter inner core the step for it is hermetically sealed
OCT image conduit.
For the above-mentioned purpose, the technical solution adopted in the present invention is:
The invention provides a kind of all-sealed micro-optical coherence tomography OCT image conduit exempted and rinsed, including lead
Tube core and the outer tube being set in outside catheter core, the catheter core include optical fiber and fibre-optical probe, and fibre-optical probe is located at the imaging
The distal end of conduit, the fibre-optical probe include miniature imaging lens, and the exit of the miniature imaging lens is coated with optics antireflecting film,
Distal end with fibre-optical probe is by guiding seal wire to enter in measured body, in outer inside pipe casing and in fibre-optical probe and guide seal wire
Isolating seal portion is provided between entrance.
Above-mentioned technical proposal is connect, miniature imaging lens are globe lens.
Above-mentioned technical proposal is connect, the near-end of imaging catheter carries jointing, is set proximally by the jointing with imaging
The control unit of standby main frame connects.
Above-mentioned technical proposal is connect, air is filled inside the outer tube.
Above-mentioned technical proposal is connect, the imaging catheter also includes torque spring, and one end of the torque spring is led with the imaging
The near-end connection of pipe.
The beneficial effect comprise that:The OCT miniature imaging conduits of the flushing-free of the present invention, disappear by using optics
Reflectance coating solves the problems, such as to cover tube wall reflection cavity, and carries out full isolating seal to imaging catheter, efficiently solve lens and
Tube wall reflection cavity problem is covered, while a variety of drawbacks for avoiding existing conduit to use purging method to bring again.
Brief description of the drawings
Below in conjunction with drawings and Examples, the invention will be further described, in accompanying drawing:
Fig. 1 is the typical structure of the consumptive material imaging catheter of the commercial cardiovascular OCT equipment of current main flow;
Fig. 2 is the distal outer schematic diagram of existing commercial imaging catheter;
Fig. 3 is the distal internal schematic diagram of existing commercial imaging catheter;
Fig. 4 is the miniature OCT image catheter configurations signal of flushing-free of the present invention;
Fig. 5 is that the distal outer of the miniature OCT image conduit of flushing-free of the embodiment of the present invention is intended to;
Fig. 6 is that the distal internal of the miniature OCT image conduit of flushing-free of the embodiment of the present invention is intended to.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only to explain the present invention, not
For limiting the present invention.
Fig. 4 is the miniature OCT image catheter configurations signal of flushing-free of the embodiment of the present invention.The imaging catheter does not have flushing liquor to enter
Mouthful, it is not necessary to irrigating catheter core, into human body after direct imaging.
Fig. 5 and Fig. 6 is the distal end detailed schematic of the miniature OCT image conduit of flushing-free of the present invention.
The all-sealed micro-optical coherence tomography OCT image conduit that the release of the embodiment of the present invention is rinsed, including conduit
Core 10 and the outer tube 20 being set in outside catheter core, the catheter core 10 include optical fiber 11 and fibre-optical probe 12, fibre-optical probe 12
Positioned at the distal end of the imaging catheter, the fibre-optical probe 12 includes miniature imaging lens, and the exit of the miniature imaging lens is coated with
Optics antireflecting film 30, the distal end with fibre-optical probe 12 by guiding seal wire D to enter in measured body, in the inside of outer tube 20 and
Isolating seal portion 40 is provided between fibre-optical probe 12 and guide seal wire D entrances.Isolating seal portion 40 can use optics UV glue,
A point UV glue is glued with syringe needle, glue, which will automatically flow into, seals conduit, UV illumination curings.
Due to not needing flushing liquor, therefore the inside of outer tube 20 filling air.
As shown in fig. 6, the imaging catheter also includes torque spring 60, one end of the torque spring 60 and the imaging catheter
Near-end connection.When torque spring 60 rotates, its other end drives fibre-optical probe rotation.
Fibre-optical probe 12 carries miniature imaging lens:Predominantly globe lens.The both ends of imaging catheter are that band connection connects respectively
The catheter proximal end of head and the distal end of catheter with imaging len, near-end are connected with the control unit of imaging device main frame, distally passed through
Seal wire is guided to be imaged into tissue, control unit drives the fibre-optical probe in catheter core to do scanning motion, realizes high-performance
Imaging.
It is of the invention thoroughly exempt to remove rinse OCT image catheter interior this conventional OCT image operating procedure, directly simplification
Operation, the accuracy of imaging results is improved, shorten Diagnostic Time, reduced patient's pain, integrally reduce operation risk;And
And also reducing the use of contrast agent, it is entirely avoided caused trace impurity enters tissue during image scanning,
Diagnosis cost is not only reduced, the long-term health of patient is highly profitable.
The imaging catheter of the present invention has at 2 points with not existing together for existing commercial imaging catheter:First, in fibre-optical probe and seal wire
Isolating seal is added between entrance, has been sealed in inside outer tube catheter core is completely isolated;Second, catheter core optical fibre microlens go out
Optical port has one layer of optics to disappear anti-AR films, and the effect of this tunic is 4% reflection for eliminating lens surface to light beam, works as imaging beam
When leaving fibre-optical probe irradiation tissue, part light can be reflected back by outer sleeve inner wall, then again anti-by lens surface
It is emitted back towards, back and forth multiple reflections, is to influence image quality of the light beam to tissue.And there is this layer to disappear anti-film, lens surface
Incident beam will not be reflected back, there would not be multiple reflections interference normal imaging between lens surface and internal surface of sleeve pipe
Problem.Because not needing contrast agent to do optical match liquid to lenticule, therefore fibre-optical probe 12 is just directly sealed, ensured
Anything including blood will not enter catheter core pollution lens influence imaging, and doctor is also without irrigating catheter core
.But the cylinder of light from molding body projects in the prior art, and cylinder is one section of transparent heat-shrink tube, fills UV rubber mouldings in it
Casting 13 ', it is unsuitable to plate the anti-film that disappears.The present invention is using the optical fiber globe lens of grinding, and the exit facet of light is glass, and suitable plating disappears anti-
Film.
To sum up, the OCT miniature imaging conduits of flushing-free of the invention, by using reflection (AR, the anti-of disappearing
Reflection) optical film solves the problems, such as to cover tube wall reflection cavity, and carries out full isolating seal to imaging catheter, effectively solves
Determine lens and set tube wall reflection cavity problem, while avoided existing conduit to use a variety of drawbacks for bringing of purging method again.
It should be appreciated that for those of ordinary skills, can according to the above description be improved or converted,
And all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Claims (5)
1. a kind of exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed, it is characterised in that including catheter core
With the outer tube being set in outside catheter core, the catheter core includes optical fiber and fibre-optical probe, and fibre-optical probe is located at the imaging catheter
Distal end, the fibre-optical probe includes miniature imaging lens, and the exit of the miniature imaging lens is coated with optics antireflecting film, carried
The distal end of fibre-optical probe is by guiding seal wire to enter in measured body, in outer inside pipe casing and in fibre-optical probe and guide seal wire entrance
Between be provided with isolating seal portion.
2. according to claim 1 exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed, its feature
It is, miniature imaging lens are globe lens.
3. according to claim 1 exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed, its feature
It is, the near-end of imaging catheter carries jointing, connects proximally by the control unit of the jointing and imaging device main frame
Connect.
4. according to claim 1 exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed, its feature
It is, filling air inside the outer tube.
5. according to claim 1 exempt the all-sealed micro-optical coherence tomography OCT image conduit rinsed, its feature
It is, the imaging catheter also includes torque spring, and one end of the torque spring is connected with the near-end of the imaging catheter.
Priority Applications (1)
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CN201710599964.6A CN107518876B (en) | 2017-07-21 | 2017-07-21 | Washing-free fully-sealed miniature Optical Coherence Tomography (OCT) imaging catheter |
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CN201710599964.6A CN107518876B (en) | 2017-07-21 | 2017-07-21 | Washing-free fully-sealed miniature Optical Coherence Tomography (OCT) imaging catheter |
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CN107518876B CN107518876B (en) | 2020-10-20 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112386230A (en) * | 2020-12-04 | 2021-02-23 | 昆山戎影医疗科技有限公司 | Balloon flushing-free OCT (optical coherence tomography) imaging catheter |
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US20050234345A1 (en) * | 2004-03-23 | 2005-10-20 | California Institute Of Technology | Forward scanning imaging optical fiber probe |
CN204500629U (en) * | 2015-03-20 | 2015-07-29 | 武汉阿格斯科技有限公司 | Ink vessel transfusing carries out OCT imaging and pressure gauge and system simultaneously |
CN104977298A (en) * | 2015-06-13 | 2015-10-14 | 李洋 | Rotary type optical-acoustic combined imaging probe and conduit |
CN105411509A (en) * | 2014-09-02 | 2016-03-23 | 乐普(北京)医疗器械股份有限公司 | OCT (optical coherence tomography) endoscopic imaging probe, manufacturing method of endoscopic imaging probe and OCT imaging catheter |
US20160367134A1 (en) * | 2015-06-19 | 2016-12-22 | Wei Su | Wide field of view optical coherence tomography imaging system |
-
2017
- 2017-07-21 CN CN201710599964.6A patent/CN107518876B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050234345A1 (en) * | 2004-03-23 | 2005-10-20 | California Institute Of Technology | Forward scanning imaging optical fiber probe |
CN105411509A (en) * | 2014-09-02 | 2016-03-23 | 乐普(北京)医疗器械股份有限公司 | OCT (optical coherence tomography) endoscopic imaging probe, manufacturing method of endoscopic imaging probe and OCT imaging catheter |
CN204500629U (en) * | 2015-03-20 | 2015-07-29 | 武汉阿格斯科技有限公司 | Ink vessel transfusing carries out OCT imaging and pressure gauge and system simultaneously |
CN104977298A (en) * | 2015-06-13 | 2015-10-14 | 李洋 | Rotary type optical-acoustic combined imaging probe and conduit |
US20160367134A1 (en) * | 2015-06-19 | 2016-12-22 | Wei Su | Wide field of view optical coherence tomography imaging system |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112386230A (en) * | 2020-12-04 | 2021-02-23 | 昆山戎影医疗科技有限公司 | Balloon flushing-free OCT (optical coherence tomography) imaging catheter |
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