CN107490419A - A kind of stem cell bank environmental forecasting and early warning system - Google Patents
A kind of stem cell bank environmental forecasting and early warning system Download PDFInfo
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- CN107490419A CN107490419A CN201710708950.3A CN201710708950A CN107490419A CN 107490419 A CN107490419 A CN 107490419A CN 201710708950 A CN201710708950 A CN 201710708950A CN 107490419 A CN107490419 A CN 107490419A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
- G01F23/24—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of resistance of resistors due to contact with conductor fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
- G01D21/02—Measuring two or more variables by means not covered by a single other subclass
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Fluid Mechanics (AREA)
- Measurement Of Levels Of Liquids Or Fluent Solid Materials (AREA)
- Alarm Systems (AREA)
Abstract
The invention provides a kind of environmental monitoring and information storage means, gather environmental information and timestamp information in real time, mode is stored using data；Present invention also offers a kind of environmental information Forecasting Methodology, is used as data sample by choosing historical data, and sample is fitted to obtain environmental information change curve, reaches prediction environmental information；Present invention also offers a kind of warning system, is alarmed in advance according to setting threshold value and environmental information prediction result；Present invention also offers a kind of stem cell bank environmental forecasting and early warning system, it is made up of environmental detector, memory, central controller and display, realizes the automatic monitoring to stem cell storage environment and alarm in advance.
Description
Technical field
The present invention relates to a kind of environmental monitoring system, and in particular to a kind of stem cell bank environmental forecasting and in advance alarm system
System.
Background technology
The storage of stem cell is needed under liquid nitrogen environment, and needs to keep liquid nitrogen liquid level to have certain height, stem cell
The liquid nitrogen liquid level of storage reduces with the gasification of liquid level, and liquid nitrogen gasification speed is also gentle with stem cell bank storage room temperature
Pressure value is relevant；In current stem cell bank monitoring system, ensure that stem cell is in good by timing detection liquid nitrogen fluid value
Good Conservation environment；It is unfavorable for the real-time effective and multi-faceted monitoring to stem cell bank environment；It is to solve the above problems, of the invention
Devising one kind has environmental forecasting and early warning system.
The content of the invention
Present invention aims at a kind of stem cell bank environmental forecasting and early warning system is provided, realize to stem cell bank ring
The detection and prediction in border, are alarmed in advance.
The present invention provides following technical scheme and realized：
The invention provides a kind of environmental monitoring and information storage means：Including passing through detector acquisition stem cell bank environment
Information simultaneously stores to environmental information；Wherein stem cell bank environmental information includes stem cell storage liquid nitrogen liquid level height, stem cell
Library storage room temperature, pressure information；Information storage means are used using the stem cell bank environment information acquisition time as index, store liquid
Nitrogen liquid level value, stem cell bank locker room temperature value and atmospheric pressure value；
The invention provides a kind of environmental information Forecasting Methodology：Choose history environment information data to be predicted, by institute
The environmental variance information of monitoring is continuous as stored liquid nitrogen liquid level value, stem cell bank locker room temperature value and atmospheric pressure value
Variable quantity, so wherein choosing history environment data method follows time nearlyer changing rule more phase approximately principle, according to as follows
The historical data that formula chooses within 20s is predicted to the temperature change in environment：
ti=t0-(1.1i-1)s.t.t0-ti≤ 20, i=N+
In above formula, i represents to choose historical data point number, tiTo choose i-th of data time information, t0For current time.
It can be obtained according to above formula, the historical data point one of selection shares 32 points (including current time).For choosing 32 couples of data [ti,v
(ti)] (i=0,1,2 ..., 31), matched using 31 rank multinomials, expression formula is as follows：
In formula, ajFor polynomial parameters,.V (t) is environmental information data, such as stores liquid nitrogen liquid level value, stem cell bank
Locker room's temperature value or atmospheric pressure value.
Temperature is predicted using the multinomial of matching, for the temporal information (t of input0+ Δ t), output prediction knot
Fruit,Current time rate of changeWhenWhen, temperature drop is presented
The trend of liter；WhenWhen, temperature will be on a declining curve；
The invention provides a kind of alarm method：According to predicted value and in moment t0+ Δ t target temperature isDefinition
Error function is：
Δ is respectively to store liquid nitrogen liquid level (Δ in formulah), stem cell bank storage room temperature (Δc) or air pressure (Δρ) by mistake
Difference.
Work as ΔhDuring ＜ 0, liquid nitrogen liquid level is warned；
Work as ΔcDuring ＞ 0, stem cell bank locker room temperature-warning；
Work as ΔρDuring ＜ 0, stem cell locker room air pressure is warned；
The invention provides a kind of stem cell bank environmental forecasting and early warning system, including：
Liquid level gauge, temperature sensor, baroceptor, for detecting the liquid nitrogen fluid value in stem cell bank environment, doing carefully
Born of the same parents' library storage room temperature angle value and atmospheric pressure value；
Memory, using the stem cell bank environment information acquisition time as index value, store the liquid nitrogen liquid in stem cell bank environment
Face amount, stem cell bank locker room temperature value and atmospheric pressure value；
Central controller, using liquid nitrogen fluid value, temperature value and atmospheric pressure value in memory, according to environmental information prediction side
Method carries out environmental information prediction, sends warning message；
Described warning message carries alarm main body, predicted state value, current state value, prediction error value；Described report
Alert main body is that liquid nitrogen liquid level is warned or stem cell bank locker room temperature-warning or stem cell locker room air pressure are warned；It is described pre-
It is the alarm main body predicted value by the environmental information Forecasting Methodology to survey state value；The current state value is current for alarm main body
Monitor value；The prediction error value is alarm main body according to the alarm method calculation error value；
Display, the environmental information detected for real-time display, including nitrogen fluid value, temperature value and atmospheric pressure value；And
Receive central controller and send warning message, carry out alarm indication；
The alarm indication, display content are the alarm main body, the predicted state value that carry in warning message, current state
Value, prediction error value.
Compared with being currently used for stem cell bank environmental management system, the present invention has the advantages that：
The present invention uses long-time historical data, and follows the time bigger principle of nearlyer correlation and choose ring for prediction
Environment information sample, higher environmental information precision of prediction can be obtained；
The present invention comparison with setting thresholding, can monitor stem cell bank ring in real time according to the look-ahead to environmental information
The situation of change of environment information, accomplish to alarm in advance, prevent in advance, advanced processing, reduce loss.
Brief description of the drawings
The present invention is further described with implementation below in conjunction with the accompanying drawings：
Fig. 1 is stem cell bank environmental forecasting of the present invention and early warning system structure chart.
Embodiment
The present invention is specifically described below by embodiment, it is necessary to it is pointed out here that be that following examples are only used
It is further described in the present invention, it is impossible to be interpreted as limiting the scope of the invention, person skilled in art can
So that some nonessential modifications and adaptations are made to the present invention according to the invention described above content.
A kind of stem cell bank environmental forecasting and early warning system as shown in Figure 1, liquid is disposed in stem cell bank liquid nitrogen
Face is counted, and can use the superconduction liquid nitrogen liquid level sensor of Cryomagnetics companies, temperature is installed in stem cell bank locker room
Sensor and baroceptor, according to cycle 1ms, environmental information is supervised including liquid nitrogen fluid value, temperature value and atmospheric pressure value
Survey, monitoring of environmental information is passed to memory preservation and display is shown；
Memory receives environmental information and timestamp information, and index value is established with timestamp, according to data to [t, h,
C, p] mode data storage；
Central controller is using 0.5s as the cycle, according to environmental information Forecasting Methodology, according to the time bigger original of nearlyer correlation
Then, 32 pairs of historical datas within 20s are chosen according to formula, become using matching prediction environmental information is carried out using 31 rank multinomials
Change curve, predict environmental information value within following 10s(Δ t ＜ 10)；More alarm method judges the liquid in environmental information
Whether nitrogen fluid value, temperature value and atmospheric pressure value exceed threshold value, send warning message in advance；
Display, real-time reception environmental information is simultaneously shown, and receives warning message, carries out alarm indication in advance.
Claims (2)
1. a kind of stem cell bank environmental forecasting and in advance alarm method, it is characterised in that：Deposited including a kind of environmental monitoring and information
Method for storing, a kind of environmental information Forecasting Methodology and a kind of alarm method；
A kind of environmental monitoring and information storage means, by detector monitors environmental information, with the environment information acquisition time
For index, the storage environment information by the way of data pair；
Described detector includes liquid level gauge, temperature sensor and baroceptor；
Described environmental information includes stem cell storage liquid nitrogen liquid level value, stem cell bank locker room temperature value and air pressure
Value；
The described environment information acquisition time is with millisecond (ms) for unit；
The data are [t, h, c, p] to specific form, and wherein t is the environment information acquisition time, and h is that stem cell stores liquid nitrogen liquid
Face height value, c are stem cell bank locker room temperature value, and p is stem cell bank locker room atmospheric pressure value；
Described a kind of environmental information Forecasting Methodology, using formula ti=t0-(1.1i-1)s.t.t0-ti≤ 20, i=N+Choose
Historical data within 20s, and use 31 rank multinomialsMatched, calculate temporal information (t0+ Δ t) output
Value is predicted value
Described a kind of alarm method, it is predicted that being worth and in moment t0+ Δ t target temperature isDefining error function is：
<mrow>
<mi>&Delta;</mi>
<mo>=</mo>
<msub>
<mover>
<mi>v</mi>
<mo>&OverBar;</mo>
</mover>
<mrow>
<msub>
<mi>t</mi>
<mn>0</mn>
</msub>
<mo>+</mo>
<mi>&Delta;</mi>
<mi>t</mi>
</mrow>
</msub>
<mo>-</mo>
<msubsup>
<mi>v</mi>
<mrow>
<msub>
<mi>t</mi>
<mn>0</mn>
</msub>
<mo>+</mo>
<mi>&Delta;</mi>
<mi>t</mi>
</mrow>
<mo>&prime;</mo>
</msubsup>
</mrow>
Δ is respectively to store liquid nitrogen liquid level (Δ in formulah), stem cell bank storage room temperature (Δc) or air pressure (Δρ) error
Value；
Work as ΔhDuring ＜ 0, liquid nitrogen liquid level is warned；
Work as ΔcDuring ＞ 0, stem cell bank locker room temperature-warning；
Work as ΔρDuring ＜ 0, stem cell locker room air pressure is warned.
2. a kind of stem cell bank environmental forecasting and early warning system based on claim 1 methods described, it is characterised in that bag
Include：Environmental detector, memory, central controller and display；
Described environmental detector includes liquid level gauge, temperature sensor, baroceptor, for detecting stem cell bank environment letter
Breath, including stem cell storage liquid nitrogen fluid value, stem cell bank locker room temperature value and atmospheric pressure value；
Described memory stores the liquid nitrogen liquid in stem cell bank environment using the stem cell bank environment information acquisition time as index value
Face amount, stem cell bank locker room temperature value and atmospheric pressure value；
Described central controller uses environmental information in memory, and environment letter is carried out using described environmental information Forecasting Methodology
Breath prediction, warning message is sent by described alarm method；
Described warning message carries alarm main body, predicted state value, current state value, prediction error value；Described alarm master
Body is that liquid nitrogen liquid level is warned or stem cell bank locker room temperature-warning or stem cell locker room air pressure are warned；The prediction shape
State value is the alarm main body predicted value by the environmental information Forecasting Methodology；The current state value is the currently monitored for alarm main body
Value；The prediction error value is alarm main body according to the alarm method calculation error value；
The display is used for the environmental information that real-time display detects, including nitrogen fluid value, temperature value and atmospheric pressure value；And connect
Warning message is sent by central controller, carries out alarm indication；
The alarm indication, display content are the alarm main body, the predicted state value that carry in warning message, current state value, in advance
Survey error amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710708950.3A CN107490419B (en) | 2017-08-17 | 2017-08-17 | Stem cell bank environment prediction and early warning system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710708950.3A CN107490419B (en) | 2017-08-17 | 2017-08-17 | Stem cell bank environment prediction and early warning system |
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| Publication Number | Publication Date |
|---|---|
| CN107490419A true CN107490419A (en) | 2017-12-19 |
| CN107490419B CN107490419B (en) | 2020-05-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710708950.3A Active CN107490419B (en) | 2017-08-17 | 2017-08-17 | Stem cell bank environment prediction and early warning system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113985798A (en) * | 2021-12-31 | 2022-01-28 | 江苏和泽干细胞基因工程有限公司 | Liquid nitrogen consumption monitoring and reminding method and device suitable for stem cell storage |
| CN117407728A (en) * | 2023-12-15 | 2024-01-16 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202286005U (en) * | 2011-10-09 | 2012-07-04 | 协和干细胞基因工程有限公司 | Stem cell storage tank with liquid level and temperature monitoring devices |
| CN205473815U (en) * | 2015-12-31 | 2016-08-17 | 深圳市第二人民医院 | Stem cell strorage device |
-
2017
- 2017-08-17 CN CN201710708950.3A patent/CN107490419B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202286005U (en) * | 2011-10-09 | 2012-07-04 | 协和干细胞基因工程有限公司 | Stem cell storage tank with liquid level and temperature monitoring devices |
| CN205473815U (en) * | 2015-12-31 | 2016-08-17 | 深圳市第二人民医院 | Stem cell strorage device |
Non-Patent Citations (1)
| Title |
|---|
| YUNLONG MA 等: "CSCBTM: China Stem Cell Bank Information", 《2010 SECOND WRI GLOBAL CONGRESS ON INTELLIGENT SYSTEMS》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113985798A (en) * | 2021-12-31 | 2022-01-28 | 江苏和泽干细胞基因工程有限公司 | Liquid nitrogen consumption monitoring and reminding method and device suitable for stem cell storage |
| CN113985798B (en) * | 2021-12-31 | 2022-04-05 | 江苏和泽干细胞基因工程有限公司 | Liquid nitrogen consumption monitoring and reminding method and device suitable for stem cell storage |
| CN117407728A (en) * | 2023-12-15 | 2024-01-16 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
| CN117407728B (en) * | 2023-12-15 | 2024-03-15 | 湖南南华生物技术有限公司 | Storage environment real-time monitoring method and system for stem cells |
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| Publication number | Publication date |
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| CN107490419B (en) | 2020-05-08 |
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Inventor after: Xiong Huaqiang Inventor before: Wang Jian Inventor before: Xiong Huaqiang Inventor before: Zhao Xiang |