CN107488424A - One kind is without benzene mountant and preparation method thereof - Google Patents
One kind is without benzene mountant and preparation method thereof Download PDFInfo
- Publication number
- CN107488424A CN107488424A CN201710738819.1A CN201710738819A CN107488424A CN 107488424 A CN107488424 A CN 107488424A CN 201710738819 A CN201710738819 A CN 201710738819A CN 107488424 A CN107488424 A CN 107488424A
- Authority
- CN
- China
- Prior art keywords
- mountant
- benzene
- limonene
- parts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09J133/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/06—Non-macromolecular additives organic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/01—Hydrocarbons
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present patent application discloses one kind without benzene mountant and preparation method thereof, is made up of the material of volumes below number：70 ~ 80 parts of limonene, 20 ~ 30 parts of polymethacrylate polymer, solvent uses natural plant essential oils, environmentally friendly, to operator without health hazard；Solute is neutral organic polymer acrylic acid macromolecular, unionization, and the dye molecule in section is not reacted after mounting, the color of histotomy is effectively preserved for a long time, can bring good economic benefit and social benefit.
Description
Technical field
The present invention relates to adhesive field, and in particular to one kind is without benzene mountant and preparation method thereof.
Background technology
Histotomy mountant, it is the stickup of the histological slides and cover glass that are used in medical tissue slice preparation process
Agent, the reading of convenient section under the microscope preserve with section.Adhesive production technology is dissolved in organic molten using natural gum more at present
Agent, specifically, being dissolved in using abies balsam or gum dammar according to 40-60% ratio in dimethylbenzene, use calcium carbonate or sodium carbonate
Carry out neutralisation processing., many drawbacks be present in so obtained histotomy mountant.On the one hand, solid solute is in acidity,
Neutralisation processing must be carried out during preparation, easily causes the acid-base value of product to fluctuate, causes preserving for histotomy
During dye the phenomenon easily faded, be unfavorable for cut into slices quality long-term holding.On the other hand, the solvent of conventional flap agent
For dimethylbenzene, dimethylbenzene tool penetrating odor, belong to lower toxicity chemical substance, have stimulation to eye and the upper respiratory tract, it is highly concentrated
When spending, there is anesthetic effect to cental system.Suction higher concentration dimethylbenzene may occur in which acute poisoning symptom in a short time；Long Term Contact
Dimethylbenzene may occur in which Chronic Effect, such as neurasthenia syndrome, and women is likely to result in menoxenia, and skin often occurs for skin contact
Skin is dry, chaps, dermatitis.Meanwhile product colloid color is yellowish slightly muddy, refractivity and bright degree are slightly worse, during use drying and
Firm pasting needs the time to grow, about 1 month.So lack at present nontoxic, permeability is good, quick cementation, long-acting holding
Histotomy mountant.
The content of the invention
The technical problems to be solved by the invention are the defects of overcoming above prior art, there is provided one kind is without benzene mountant
Method, can it is nontoxic, permeability is good, quick cementation, long-acting holding.
The technical solution of the present invention is as follows：One kind is made up of without benzene mountant the material of volumes below number：Lemon
70 ~ 80 parts of alkene, 20 ~ 30 parts of polymethacrylate polymer.
Obtained mountant is colloid, uses solvent as limonene, is natural plant essential oils, colourless oil liquid, there is class
Lemonish fragrance, it is a kind of natural function monoterpene, is widely used in food as essence and flavoring agent additive；
Limonene is environmentally friendly, to operator without health hazard.Solute component is different from the solute of traditional product, polymethylacrylic acid
Esters polymer is neutral polymerization macromolecular body, is not in the fluctuation of acid-base value during preparation, storage and use, effectively
Prevent the ill effects such as dyestuff colour fading of the histotomy during preservation.
Preferably, the limonene is D- limonenes, L-citrene or the two mixture.
Preferably, the polymethacrylate polymer is polyisobutyl methacrylate, polymethylacrylic acid third
One kind in ester, polyethyl methacrylate, polymethyl methacrylate.
A kind of method of no benzene mountant, weighs limonene, and 5 ~ 10min is stirred with 500 ~ 800r/min rotating speed：Then
The polymethacrylate polymer that will be weighed in proportion using funnel, continues 30 ~ 40min of stirring, until polymethyl
Esters of gallic acid polymer is completely dissolved, and is got product.
The beneficial effects of the invention are as follows：
1) solvent uses natural plant essential oils, and limonene is environmentally friendly, to operator without health hazard；
2) index of refraction of mountant is 1.471-1.48, and refractive property is substantially better than tradition with section after mounting to the permeability of light
Mountant；
3) effectively shorten the chip drying time, be completely dried within 3 days after mounting, cover glass firm pasting；
4) the colloid solute component that the present invention uses is organic polymer acrylic acid macromolecular, and pH value is neutral, unionization, after mounting
Dye molecule in section is not reacted, effectively preserves the color of histotomy for a long time.
Embodiment
The present invention is described in further details with specific embodiment below, but the present invention is not only limited in detail below in fact
Apply example.
Embodiment provided below is simultaneously not used to the scope that the limitation present invention is covered, described step nor with
To limit its execution sequence.Those skilled in the art do conspicuously improved with reference to existing common knowledge to the present invention, also fall
Enter within the protection domain of application claims.
Embodiment one
One kind is made up of without benzene mountant the material of volumes below number：70 parts of D- limonenes, polyisobutyl methacrylate 20
Part.
A kind of preparation method of no benzene mountant, comprises the following steps：Limonene is weighed, is stirred with 500r/min rotating speed
5min：Then the polymethacrylate polymer that will be weighed in proportion using funnel, continue to stir 30min, until poly- first
Base acrylic polymer is completely dissolved, and is got product.
Embodiment two
One kind is made up of without benzene mountant the material of volumes below number：80 parts of L-citrene, polyisobutyl methacrylate
30 parts.
A kind of preparation method of no benzene mountant, comprises the following steps：Limonene is weighed, is stirred with 800r/min rotating speed
10min：Then the polymethacrylate polymer that will be weighed in proportion using funnel, continue to stir 40min, until poly- first
Base acrylic polymer is completely dissolved, and is got product.
Embodiment three
One kind is made up of without benzene mountant the material of volumes below number：78 parts of D- limonenes, both L-citrenes mixture,
25 parts of polyisobutyl methacrylate.
A kind of preparation method of no benzene mountant, comprises the following steps：780 milliliters of limonene is put into vial, is added
It is placed on after entering magnetic stir bar on magnetic stirring apparatus, starts moderate-speed mixer.250 grams of polyisobutyl methacrylates are passed through into triangle
Funnel is slowly added in limonene, container capping（Without sealing）Stirring 30 minutes, until polyisobutyl methacrylate is complete
Dissolving.Finished product is distributed into glass container or chemical industry organic solvent package bottle special preserves.
Listed above is only the specific embodiment of the present invention, it is clear that the embodiment the invention is not restricted to more than.This area
The those of ordinary skill's all deformations that directly can export or associate from present disclosure, all should belong to the present invention's
Protection domain.
Claims (4)
1. one kind is without benzene mountant, it is characterised in that is made up of the material of volumes below number：70 ~ 80 parts of limonene, poly- methyl
20 ~ 30 parts of acrylic polymer.
2. no benzene mountant according to claim 1, it is characterised in that the limonene is D- limonenes, L-citrene
Or the two mixture.
3. no benzene mountant according to claim 1, it is characterised in that the polymethacrylate polymer is poly-
One kind in Isobutyl methacrylate, polypropylmethacryla,es, polyethyl methacrylate, polymethyl methacrylate.
4. a kind of preparation method without benzene mountant based on described in claim 1, it is characterised in that comprise the following steps：Claim
Limonene is taken, 5 ~ 10min is stirred with 500 ~ 800r/min rotating speed：Then the polymethyl that will be weighed in proportion using funnel
Esters of gallic acid polymer, continue 30 ~ 40min of stirring, until polymethacrylate polymer is completely dissolved, get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738819.1A CN107488424B (en) | 2017-08-25 | 2017-08-25 | A kind of no benzene mountant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710738819.1A CN107488424B (en) | 2017-08-25 | 2017-08-25 | A kind of no benzene mountant and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107488424A true CN107488424A (en) | 2017-12-19 |
| CN107488424B CN107488424B (en) | 2019-05-21 |
Family
ID=60646735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710738819.1A Active CN107488424B (en) | 2017-08-25 | 2017-08-25 | A kind of no benzene mountant and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107488424B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109943239A (en) * | 2017-12-21 | 2019-06-28 | 哈尔滨格林标本技术开发有限公司 | A kind of preparation method of nontoxic histotomy mounting glue |
| CN112920544A (en) * | 2021-03-16 | 2021-06-08 | 桂林医学院附属医院 | Tasteless tablet and preparation method thereof |
| CN113861843A (en) * | 2021-09-23 | 2021-12-31 | 南昌雨露实验器材有限公司 | Neutral odorless gum and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037168A (en) * | 1997-12-31 | 2000-03-14 | Cytonix Corporation | Microbiological assembly comprising resealable closure means |
| CN104155160A (en) * | 2014-08-12 | 2014-11-19 | 陆可望 | Tissue dewaxing transparent agent free of benzene |
| CN106370503A (en) * | 2016-08-31 | 2017-02-01 | 宁波同盛生物科技有限公司 | Organic quick drying mounting medium |
-
2017
- 2017-08-25 CN CN201710738819.1A patent/CN107488424B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037168A (en) * | 1997-12-31 | 2000-03-14 | Cytonix Corporation | Microbiological assembly comprising resealable closure means |
| CN104155160A (en) * | 2014-08-12 | 2014-11-19 | 陆可望 | Tissue dewaxing transparent agent free of benzene |
| CN106370503A (en) * | 2016-08-31 | 2017-02-01 | 宁波同盛生物科技有限公司 | Organic quick drying mounting medium |
Non-Patent Citations (1)
| Title |
|---|
| 郑绍成 等: "醇酸树脂酸值测定的溶剂绿色化研究", 《涂料工业》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109943239A (en) * | 2017-12-21 | 2019-06-28 | 哈尔滨格林标本技术开发有限公司 | A kind of preparation method of nontoxic histotomy mounting glue |
| CN112920544A (en) * | 2021-03-16 | 2021-06-08 | 桂林医学院附属医院 | Tasteless tablet and preparation method thereof |
| CN113861843A (en) * | 2021-09-23 | 2021-12-31 | 南昌雨露实验器材有限公司 | Neutral odorless gum and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107488424B (en) | 2019-05-21 |
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