CN107485434A - A kind of spinal vertebral booster and its manufacture method - Google Patents
A kind of spinal vertebral booster and its manufacture method Download PDFInfo
- Publication number
- CN107485434A CN107485434A CN201710710259.9A CN201710710259A CN107485434A CN 107485434 A CN107485434 A CN 107485434A CN 201710710259 A CN201710710259 A CN 201710710259A CN 107485434 A CN107485434 A CN 107485434A
- Authority
- CN
- China
- Prior art keywords
- bolt
- booster
- threaded portion
- manufacture method
- spinal vertebral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 19
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 10
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 10
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 7
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 238000013268 sustained release Methods 0.000 claims description 7
- 239000004005 microsphere Substances 0.000 claims description 6
- 239000012730 sustained-release form Substances 0.000 claims description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000004945 emulsification Methods 0.000 claims description 4
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims 1
- 235000011613 Pinus brutia Nutrition 0.000 claims 1
- 241000018646 Pinus brutia Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 2
- 208000010392 Bone Fractures Diseases 0.000 description 5
- 206010017076 Fracture Diseases 0.000 description 5
- 206010023509 Kyphosis Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000000750 progressive effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 210000004446 longitudinal ligament Anatomy 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 206010041541 Spinal compression fracture Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000012779 reinforcing material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 206010041569 spinal fracture Diseases 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7071—Implants for expanding or repairing the vertebral arch or wedged between laminae or pedicles; Tools therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7094—Solid vertebral fillers; devices for inserting such fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
Abstract
The present invention relates to a kind of spinal vertebral booster and its manufacture method, including the body of bolt and tail end, it is characterized in that, the body of bolt also includes front portion, threaded portion and hollow bulb, the front end is warhead shape, surface is smooth, body of bolt surface is threaded portion, threaded portion includes cancellous threads and cortex bone thread, cancellous threads account for the 2/3 of threaded portion, in the bottom of front end, cortex bone thread connects with cancellous threads, account for the 1/3 of threaded portion, the pitch of cancellous threads is more than the pitch of cancellous threads, the hollow bulb is inside the body of bolt, hollow bulb continues up to afterbody from body of bolt front portion, for hollow through hole；The tail end is cylinder, and cylinder is 3.5mm interior hexagonal, can be meshed with inner hexagon spanner.Cavity is remained in vertebra after reset, supports and hinders vertebra it is an advantage of the invention that can effectively fill and hinder, promotes Bone Ingrowth, reaches and hinders vertebra healing, while wound is smaller, it is thus also avoided that the secondary repetition operated on to wound injures.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of spinal vertebral booster and its manufacture method.
Background technology
Thoracolumbar burst fractures using fixation in way of escape short-segment pedicle instrument be in internal fixation of spine history it is landmark
It is progressive, there is the advantages that Fusion levels are few, fixed definite.Clinically the type is fractured often through posterior Pedicle screw at present
Distraction reduction, posterolateral fusion are treated, and the art formula is resetted by the apparatus of Postural reduction and pedicle screw makes wound
The vertebral height of vertebra is recovered, and is corrected kyphosis deformity and is obtained the bone piece for protruding into canalis spinalis by the extensional process of posterior longitudinal ligament
A certain degree of Indirect reduction (need to separately being depressurized with neurothlipsis symptom person), but Clinical Follow-up be frequently found implantation after it is interior
Fixed fracture and correction are lost, and severe patient even the complication such as progressive kyphosis deformity occurs after interior fixation is taken out, and is still current
The problem of to be solved so far.Generally believe that although position and pedicle screw apparatus distraction reduction can utilize forward and backward longitudinal ligament at present
Retracting repositioning effect with annulus fibrosus disci intervertebralis makes the height for hindering vertebra and profile reach close normal, but to centrum interior cancellous bone
Reset response it is but very faint, centrum in-seam trabecular support structural damage is not corrected, formed so-called " eggshell "
Sample change is centrum internal cavity, the cavity after bone grafting in recovery process by fibrous connective tissue and non-bone tissue is filled,
Thus before centrum, center pillar lacks effectively support, causes stress to be conducted by rear apparatus, so as to interior fixation can because of fatigue and
The loss of collapse of vertebra and height occurs after fracture, or interior fixed taking-up, progressive kyphosis deformity occurs even in severe patient
Spinal cord injury.In addition, it occur frequently that soleplate is fractured and collapsed after thoracolumbar fracture, Oner etc. thinks tough when pedicle screw resets
The traction action of band can preferably recover centrum front and back walls and the height of surrounding endplate, but can not make the soleplate center of depression
Domain resets, and this is also to cause to be implanted into another main cause that postcentrum is highly lost.Therefore, spine fracture is postoperative, can make reset
Postcentrum cavity, which is effectively filled, to be supported and completes Bone Ingrowth, is the problem of current letter is to be solved.
The content of the invention
It is an object of the invention to which the effectively filling of postcentrum remnants cavitys early stage can be resetted to vertebral fracture, promote cavity bone
Grow into, avoid the spine fracture later stage from collapse of vertebra, bone nonunion even the spinal vertebral booster of the complication such as kyphosis deformity occur
And its manufacture method.
To solve above-mentioned technical problem, structure of the invention includes the body of bolt and tail end, before the body of bolt also includes
Portion, threaded portion and hollow bulb, the front end are warhead shape, and surface is smooth, and body of bolt surface is threaded portion, and threaded portion includes spongiosa
Bone thread and cortex bone thread, cancellous threads account for the 2/3 of threaded portion, in the bottom of front end, cortex bone thread and spongiosa murices
Line connects, and accounts for the 1/3 of threaded portion, the pitch of cancellous threads is more than the pitch of cancellous threads, and the hollow bulb is in the body of bolt
Inside, hollow bulb continue up to afterbody from body of bolt front portion, are hollow through hole；The tail end is cylinder, cylinder 3.5mm
Interior hexagonal, can be meshed with inner hexagon spanner.
Further, the spinal vertebral booster uses passes through absorption process and nanometer hydroxyapatite carrier by BMP-2
Be prepared into sustained-release micro-spheres with reference to and using the compound PLLA of multi-emulsion method, sustained-release micro-spheres be combined with each other centrum booster is made, its into
It is BMP-2 to divide ratio:HA:PLLA=15mg:15mg:200mg.
Further, according to the different size of spinal vertebral booster, the corresponding body of bolt has different the body of bolt
The diameter (containing screw thread) of specification is 6.0mm, 6.5mm, 7.0mm and 7.5mm.
Further, according to the different size of spinal vertebral booster, respective bolt body has different the described body of bolt
The length of specification is 40mm, 45mm, 5.0mm and 5.5mm.
Further, a diameter of 2mm of the hollow bulb of the described body of bolt, hollow bulb can be inserted into guide pin.
Further, the body of bolt is advanced by screw thread rotation on the body of bolt.
After said structure and material, it is an advantage of the invention that can effectively fill hinder reset in vertebra after remain cavity,
Vertebra is hindered in support, promotes Bone Ingrowth, is reached and is hindered vertebra healing, while wound is smaller, it is thus also avoided that the secondary repetition operated on to wound
Injury, spinal vertebral reinforcing material solves carries out high heat infringement caused by reinforcement backbone and pressuring nerve using bone cement
It is dangerous；Meanwhile the spinal vertebral booster is simple in construction, simple operation, it is easier to the operation of doctor.
Brief description of the drawings
Accompanying drawing is used for providing a further understanding of the present invention, and a part for constitution instruction, the reality with the present invention
Apply example to be used to explain the present invention together, be not construed as limiting the invention.In the accompanying drawings：
Fig. 1 is the structural representation of the present invention；
Fig. 2 is the external structure of the present invention.
Embodiment
The preferred embodiments of the present invention are illustrated below in conjunction with accompanying drawing, it will be appreciated that described herein preferred real
Apply example to be merely to illustrate and explain the present invention, be not intended to limit the present invention.
As shown in figure 1, the present invention relates to a kind of spinal vertebral booster and its manufacture method, including the body of bolt 1 and tail end
2, it is warhead shape that the body of bolt, which also includes front portion 3, threaded portion 4 and hollow bulb 5, institute front end, and surface is smooth, and body of bolt surface is screw thread
Portion, threaded portion include cancellous threads 6 and cortex bone thread 7, and the pitch of cancellous threads is more than the pitch of cancellous threads；In
Inside the body of bolt, hollow bulb continues up to afterbody from body of bolt front portion in empty portion, is hollow through hole；Tail end cylinder, cylinder
For interior hexagonal, can be meshed with inner hexagon spanner.
BMP-2 is combined by absorption process with nanometer hydroxyapatite carrier and is prepared into using the compound PLLA of multi-emulsion method slow
Release microballoon (BMP-2:HA:PLLA=15mg:15mg:200mg), sustained-release micro-spheres are be combined with each other by special process and centrum is made
Booster, and according to centrum size, Multiple Type, including diameter (containing screw thread) 6.0mm, 6.5mm, 7.0mm and 7.5mm are prepared,
Long 40mm, 45mm, 5.0mm and 5.5mm, head end are converged to the gradual less cone of diameter, and 2/3 is spongiosa murices before booster
Line, rear 1/3 is cortex bone thread.Whole screw is hollow, diameter 2mm, can be inserted into guide pin guiding inner core and is screwed into.Afterbody is 3.5mm
Interior hexagonal, it is easy to be screwed into centrum.The absorbable centrum booster fixed form of BMP-2 sustained releases both effectively fills the cavity after resetting,
And can provides certain bearing load for soleplate, is new optimal fixed form.
BMP-2 is combined by absorption process with nanometer hydroxyapatite carrier and is prepared into using the compound PLLA of multi-emulsion method slow
Microballoon is released, sustained-release micro-spheres, which are be combined with each other, by special process is made centrum booster, is slowly dropped after fixed in booster centrum
Solve and be sustained BMP-2/ nanometer hydroxyapatite microballoons.The environment similar in centrum is prepared in vitro to determine by Shu Jiafa
BMP-2 sustained concentrations.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, although with reference to foregoing reality
Apply example the present invention is described in detail, for those skilled in the art, it still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic.All essences in the present invention
God any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection with principle.
Claims (6)
1. a kind of spinal vertebral booster and its manufacture method, including the body of bolt and tail end, it is characterised in that the body of bolt is also
It is warhead shape including anterior, threaded portion and hollow bulb, the front end, surface is smooth, and body of bolt surface is threaded portion, and threaded portion is wrapped
Cancellous threads and cortex bone thread are included, cancellous threads account for the 2/3 of threaded portion, in the bottom of front end, cortex bone thread and pine
Matter bone thread connects, and accounts for the 1/3 of threaded portion, and the pitch of cancellous threads is more than the pitch of cancellous threads, and the hollow bulb exists
Inside the body of bolt, hollow bulb continues up to afterbody from body of bolt front portion, is hollow through hole；The tail end is cylinder, cylinder
For 3.5mm interior hexagonal, can be meshed with inner hexagon spanner.
2. a kind of spinal vertebral booster according to claim 1 and its manufacture method, it is characterised in that：The backbone vertebra
Body booster, which uses, to be combined with nanometer hydroxyapatite carrier by absorption process by BMP-2 and uses the compound PLLA of multi-emulsion method to prepare
Into sustained-release micro-spheres, sustained-release micro-spheres are be combined with each other centrum booster is made, its composition ratio is BMP-2:HA:PLLA=15mg:
15mg:200mg。
3. a kind of spinal vertebral booster according to claim 1 and its manufacture method, it is characterised in that：The body of bolt
According to the different size of spinal vertebral booster, it is 6.0mm that the corresponding body of bolt, which has the diameter (containing screw thread) of different size,
6.5mm, 7.0mm and 7.5mm.
4. a kind of spinal vertebral booster according to claim 1 and its manufacture method, it is characterised in that：Described bolt
For body according to the different size of spinal vertebral booster, it is 40mm, 45mm, 5.0mm that respective bolt body, which has the length of different size,
And 5.5mm.
5. a kind of spinal vertebral booster according to claim 1 and its manufacture method, it is characterised in that：Described bolt
The a diameter of 2mm of hollow bulb of body, hollow bulb can be inserted into guide pin.
6. a kind of spinal vertebral booster according to claim 1 and its manufacture method, it is characterised in that：The body of bolt
Advanced by screw thread rotation on the body of bolt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710710259.9A CN107485434A (en) | 2017-08-18 | 2017-08-18 | A kind of spinal vertebral booster and its manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710710259.9A CN107485434A (en) | 2017-08-18 | 2017-08-18 | A kind of spinal vertebral booster and its manufacture method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107485434A true CN107485434A (en) | 2017-12-19 |
Family
ID=60646411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710710259.9A Pending CN107485434A (en) | 2017-08-18 | 2017-08-18 | A kind of spinal vertebral booster and its manufacture method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107485434A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111631844A (en) * | 2020-05-29 | 2020-09-08 | 四川大学华西医院 | Double-skin elastic fixation fusion cage |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202027700U (en) * | 2011-01-19 | 2011-11-09 | 陈允震 | Density composite thread pedicle screw |
| CN106073952A (en) * | 2016-07-18 | 2016-11-09 | 中国人民解放军第二军医大学第二附属医院 | A kind of vertebral body booster treating compression fracture of vertabral body |
| CN106691525A (en) * | 2017-01-06 | 2017-05-24 | 南京市六合区人民医院 | Fixing system for transplant in anterior cruciate ligament reconstruction |
| CN106902397A (en) * | 2017-01-06 | 2017-06-30 | 南京市六合区人民医院 | BMP 2/PLLA/nHA sustained-release micro-spheres and preparation method thereof |
-
2017
- 2017-08-18 CN CN201710710259.9A patent/CN107485434A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202027700U (en) * | 2011-01-19 | 2011-11-09 | 陈允震 | Density composite thread pedicle screw |
| CN106073952A (en) * | 2016-07-18 | 2016-11-09 | 中国人民解放军第二军医大学第二附属医院 | A kind of vertebral body booster treating compression fracture of vertabral body |
| CN106691525A (en) * | 2017-01-06 | 2017-05-24 | 南京市六合区人民医院 | Fixing system for transplant in anterior cruciate ligament reconstruction |
| CN106902397A (en) * | 2017-01-06 | 2017-06-30 | 南京市六合区人民医院 | BMP 2/PLLA/nHA sustained-release micro-spheres and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 向柄彦;郭元;: "载药组织工程支架的构建及其性能研究" * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111631844A (en) * | 2020-05-29 | 2020-09-08 | 四川大学华西医院 | Double-skin elastic fixation fusion cage |
| CN111631844B (en) * | 2020-05-29 | 2022-12-23 | 四川大学华西医院 | Double-skin elastic fixation fusion cage |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2006287169B2 (en) | Implantable devices and methods for treating micro-architecture deterioration of bone tissue | |
| EP2173268B1 (en) | Devices for stabilizing bone compatible for use with bone screws | |
| US8998923B2 (en) | Threaded bone filling material plunger | |
| US8133232B2 (en) | Expandable bone device | |
| US7621952B2 (en) | Implants and methods for treating bone | |
| US20080281364A1 (en) | Systems, devices and methods for stabilizing bone | |
| Fransen | Increasing pedicle screw anchoring in the osteoporotic spine by cement injection through the implant: technical note and report of three cases | |
| US20150230848A1 (en) | Self-expanding bone stabilization devices | |
| WO2010017631A1 (en) | Dynamic pedicle screw | |
| CN107485434A (en) | A kind of spinal vertebral booster and its manufacture method | |
| US20170304073A1 (en) | Bone scaffold improvements | |
| CN104688390A (en) | Net-shaped supporting device | |
| US10478522B2 (en) | Biocompatible material in granules made of metal material or metal alloys and use of said granules for vertebroplasty | |
| CN102488574A (en) | Interbody fusion cage | |
| WO2019033082A1 (en) | Demineralized bone fiber composition for augmentation of fixation | |
| JP2007289551A (en) | Bone prosthesis | |
| JP2023521374A (en) | Bone fixation implant with cortical stabilization | |
| CN204618380U (en) | A kind of eyelid retractor being used for the treatment of femur head necrosis | |
| CN214761409U (en) | Multi-direction uniform bone grafting funnel for bone grafting fusion | |
| CN106963521B (en) | One kind can extend assembly type artificial vertebral body in vivo | |
| CN110169847A (en) | A kind of organizational project cervical fusion cage and application method | |
| CN104720884A (en) | Support used for femoral head necrosis treatment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171219 |
|
| RJ01 | Rejection of invention patent application after publication |