CN107462507B - Porous material filtration rate measuring instrument - Google Patents
Porous material filtration rate measuring instrument Download PDFInfo
- Publication number
- CN107462507B CN107462507B CN201710686748.5A CN201710686748A CN107462507B CN 107462507 B CN107462507 B CN 107462507B CN 201710686748 A CN201710686748 A CN 201710686748A CN 107462507 B CN107462507 B CN 107462507B
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- CN
- China
- Prior art keywords
- porous material
- groove
- filtration rate
- measuring instrument
- hollow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000011148 porous material Substances 0.000 title claims abstract description 37
- 238000001914 filtration Methods 0.000 title claims abstract description 29
- 238000007789 sealing Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000002347 injection Methods 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 9
- 239000012620 biological material Substances 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 3
- 238000005259 measurement Methods 0.000 abstract description 2
- 239000012154 double-distilled water Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 3
- 229960001225 rifampicin Drugs 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/0806—Details, e.g. sample holders, mounting samples for testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N2015/0846—Investigating permeability, pore-volume, or surface area of porous materials by use of radiation, e.g. transmitted or reflected light
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a porous material filtration rate measuring instrument, which comprises: a first hollow housing comprising an outward projection; a second hollow housing comprising a recess matching the shape of the protrusion; the depth of the groove is greater than the length of the protrusion; the protruding part is embedded into the groove and connected with the groove, and a cavity is formed in the groove; a sealing ring is arranged in the cavity and used for placing a porous material to be tested; the first hollow shell and the second hollow shell are also respectively provided with a first water injection hole and a second water injection hole which are used for respectively injecting solutions with different concentrations into the measuring instrument. The invention has few required parts, can complete the measurement of the filtration rate of the porous material only by two hollow shells and sealing rings, and has simple structure; the disassembly and the assembly are convenient and easy, and the time and the labor are saved; the material is easy to obtain, and the cost is low; can be applied to the fields of medical biological materials and biological medicine and pharmacology on a large scale.
Description
Technical Field
The invention relates to the field of drug slow release, in particular to a porous material filtration rate measuring instrument.
Background
The slow releasing system of medicine is the focus and key point of the research and development of biological medicine and pharmacology, and the porous biological material is the key point of the successful research of the slow releasing system of medicine. There are many evaluation indexes for porous biomaterials, and the most important index is the filtration rate of the porous material.
At present, the existing porous biological material filtration rate measuring instrument is too complex, too high in cost, time-consuming and labor-consuming, and not beneficial to large-scale popularization and application. Therefore, it is very important to develop a convenient and easy instrument for measuring the filtration rate of porous biological materials.
Disclosure of Invention
The invention aims to provide a porous material filtration rate measuring instrument which is convenient and easy to operate, saves the economic cost and the time cost and can be suitable for porous materials to be measured with different specifications.
In order to achieve the above object, the present invention provides a porous material filtration rate measuring instrument, comprising:
a first hollow housing comprising an outward projection;
a second hollow housing comprising a recess matching the shape of the protrusion;
the depth of the groove is greater than the length of the protrusion;
the protruding part is embedded into the groove and connected with the groove, and a cavity is formed in the groove;
a sealing ring is arranged in the cavity and used for placing a porous material to be tested;
the first hollow shell and the second hollow shell are also respectively provided with a first water injection hole and a second water injection hole which are used for respectively injecting solutions with different concentrations into the measuring instrument.
The above porous material filtration rate measuring instrument, wherein the first hollow shell and the second hollow shell are hollow cylinders.
The above porous material filtration rate measuring instrument, wherein the protrusion is a hollow cylinder having an external thread; the groove is a hollow cylinder with internal threads; the protruding part is connected with the groove through threads.
The above porous material filtration rate measuring instrument, wherein the sealing ring is a silica gel ring.
The above porous material filtration rate measuring instrument, wherein the first hollow shell and the second hollow shell are made of stainless steel.
Compared with the prior art, the invention has the following beneficial effects:
the invention has few required parts, can complete the measurement of the filtration rate of the porous material only by two hollow shells and sealing rings, and has simple structure; the disassembly and the assembly are convenient and easy, and the time and the labor are saved; the material is easy to obtain, and the cost is low; can be applied to the fields of medical biological materials and biological medicine and pharmacology on a large scale.
Drawings
FIG. 1 is a cross-sectional view of a porous material filtration rate measuring instrument according to the present invention before assembly;
fig. 2 is a sectional view of the porous material filtration rate measuring instrument according to the present invention after assembly.
Detailed Description
The invention will be further described by the following specific examples in conjunction with the drawings, which are provided for illustration only and are not intended to limit the scope of the invention.
As shown in fig. 1 and 2, the present invention provides a porous material filtration rate measuring instrument, including:
a first hollow shell 1 comprising an outward projection 11;
a second hollow shell 2 comprising a recess 21 matching the shape of said protrusion 11;
the depth of the groove 21 is greater than the length of the protrusion 11 to leave a part of the space;
the protruding part 11 is embedded in the groove 21 and connected with the groove, and a cavity is formed in the groove 21;
a sealing ring 3 is arranged in the cavity, and a porous material 4 to be tested is placed in the sealing ring 3;
the first hollow shell 1 and the second hollow shell 2 are further respectively provided with a first water injection hole 12 and a second water injection hole 22, which are used for respectively injecting solutions with different concentrations into the measuring instrument.
The first hollow shell 1 and the second hollow shell 2 are hollow cylinders.
The projection 11 is a hollow cylinder with an external thread; the groove 21 is a hollow cylinder with internal threads; the protrusion 11 is screwed into the groove 21.
The sealing ring 3 is a silica gel ring.
The first hollow shell and the second hollow shell are made of stainless steel.
The working principle is as follows: the porous material completes the filtration by the osmosis of the pore structure, and the solution with different concentrations (such as liquid medicine with certain concentration and water) is required to form concentration difference to form osmotic pressure to generate the filtration. The liquid medicine generates osmosis action through the pore structure of the porous material, and the size and the number of the pore diameter of the porous material influence the osmosis speed. After the porous material is placed in a sealing ring of the filtration rate measuring instrument, liquid with different concentrations is injected into two sides of the porous material, and after a certain time, the filtration rate of the porous material can be measured by measuring the concentration change of the solution on one side.
The working steps are as follows: taking rifampicin with a concentration of 1mg/ml as an example, rifampicin was put into one side of the measuring device of the present invention, double distilled water was put into one side, and the change in concentration of double distilled water was measured every day for 30 consecutive days. The double distilled water and rifampicin were extracted daily by needle, 100. mu.l each was added to a 96-well plate to prepare 6 multiple wells, the control group was pure water, and absorbance at 450nm wavelength was measured by microplate reader. And (3) averaging the OD value of each hole, continuously measuring for 30 days and drawing a standard curve, wherein the slope of the standard curve is the average filtration rate of the porous material in a certain time period.
In conclusion, the device needs few parts, can measure the filtration rate of the porous material by only two hollow shells and sealing rings, and has a simple structure; the disassembly and the assembly are convenient and easy, and the time and the labor are saved; the material is easy to obtain, and the cost is low; can be applied to the fields of medical biological materials and biological medicine and pharmacology on a large scale.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.
Claims (5)
1. A porous material filtration rate measuring instrument, comprising:
a first hollow housing comprising an outward projection;
a second hollow housing comprising a recess matching the shape of the protrusion;
the depth of the groove is greater than the length of the protrusion;
the protruding part is embedded into the groove and connected with the groove, and a cavity is formed in the groove;
a sealing ring is arranged in the cavity and used for placing a porous material to be tested;
the first hollow shell and the second hollow shell are also respectively provided with a first water injection hole and a second water injection hole which are used for respectively injecting solutions with different concentrations into the measuring instrument.
2. The porous material filtration rate measuring instrument of claim 1, wherein the first hollow housing and the second hollow housing are hollow cylinders.
3. The porous material filtration rate measuring instrument according to claim 1, wherein the protrusion is a hollow cylinder having an external thread; the groove is a hollow cylinder with internal threads; the protruding part is connected with the groove through threads.
4. The porous material filtration rate measuring instrument according to claim 1, wherein the sealing ring is a silica gel ring.
5. The apparatus for measuring filtration rate of a porous material according to claim 1, wherein the first hollow housing and the second hollow housing are made of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710686748.5A CN107462507B (en) | 2017-08-11 | 2017-08-11 | Porous material filtration rate measuring instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710686748.5A CN107462507B (en) | 2017-08-11 | 2017-08-11 | Porous material filtration rate measuring instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107462507A CN107462507A (en) | 2017-12-12 |
| CN107462507B true CN107462507B (en) | 2020-01-21 |
Family
ID=60547379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710686748.5A Expired - Fee Related CN107462507B (en) | 2017-08-11 | 2017-08-11 | Porous material filtration rate measuring instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107462507B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201331483Y (en) * | 2009-01-05 | 2009-10-21 | 王利兵 | Plastic film organic substance transmittance detecting device |
| CN104458504A (en) * | 2013-09-16 | 2015-03-25 | 中国科学院大连化学物理研究所 | Diffusion cell membrane module and diffusion cell |
| CN205404355U (en) * | 2016-02-24 | 2016-07-27 | 广州市杉特无纺布科技有限公司 | Be used for quick determining instrument of drier packing combined material gas permeability |
| CN105973785A (en) * | 2016-06-24 | 2016-09-28 | 广西金桂浆纸业有限公司 | Device for testing boundary permeability resistance of paper |
| CN106489071A (en) * | 2014-07-09 | 2017-03-08 | 帕雷科技有限公司 | Method for measuring the infiltration of the penetrant by film |
-
2017
- 2017-08-11 CN CN201710686748.5A patent/CN107462507B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201331483Y (en) * | 2009-01-05 | 2009-10-21 | 王利兵 | Plastic film organic substance transmittance detecting device |
| CN104458504A (en) * | 2013-09-16 | 2015-03-25 | 中国科学院大连化学物理研究所 | Diffusion cell membrane module and diffusion cell |
| CN106489071A (en) * | 2014-07-09 | 2017-03-08 | 帕雷科技有限公司 | Method for measuring the infiltration of the penetrant by film |
| CN205404355U (en) * | 2016-02-24 | 2016-07-27 | 广州市杉特无纺布科技有限公司 | Be used for quick determining instrument of drier packing combined material gas permeability |
| CN105973785A (en) * | 2016-06-24 | 2016-09-28 | 广西金桂浆纸业有限公司 | Device for testing boundary permeability resistance of paper |
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| Publication number | Publication date |
|---|---|
| CN107462507A (en) | 2017-12-12 |
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