CN107459590A - A kind of preparation method of hyaluronic acid quaternary ammonium salt - Google Patents
A kind of preparation method of hyaluronic acid quaternary ammonium salt Download PDFInfo
- Publication number
- CN107459590A CN107459590A CN201710880823.1A CN201710880823A CN107459590A CN 107459590 A CN107459590 A CN 107459590A CN 201710880823 A CN201710880823 A CN 201710880823A CN 107459590 A CN107459590 A CN 107459590A
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- Prior art keywords
- hyaluronic acid
- preparation
- quaternary ammonium
- solution
- acid
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710880823.1A CN107459590B (en) | 2017-09-26 | 2017-09-26 | Preparation method of hyaluronic acid quaternary ammonium salt |
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CN201710880823.1A CN107459590B (en) | 2017-09-26 | 2017-09-26 | Preparation method of hyaluronic acid quaternary ammonium salt |
Publications (2)
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CN107459590A true CN107459590A (en) | 2017-12-12 |
CN107459590B CN107459590B (en) | 2021-03-23 |
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CN201710880823.1A Active CN107459590B (en) | 2017-09-26 | 2017-09-26 | Preparation method of hyaluronic acid quaternary ammonium salt |
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CN (1) | CN107459590B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110790960A (en) * | 2019-11-13 | 2020-02-14 | 华熙生物科技股份有限公司 | Hyaluronic acid quaternary ammonium salt crosslinked powder and preparation method and application thereof |
CN114133465A (en) * | 2020-09-03 | 2022-03-04 | 山东华熙海御生物医药有限公司 | Preparation method of potassium hyaluronate, obtained product and application |
CN114397399A (en) * | 2021-12-31 | 2022-04-26 | 华熙生物科技股份有限公司 | Method for determining content of quaternary ammonium salt in hyaluronic acid-quaternary ammonium salt polymer |
CN116041565A (en) * | 2022-11-18 | 2023-05-02 | 山东焦点福瑞达生物股份有限公司 | Preparation and purification method of sodium hyaluronate cationic quaternary ammonium salt in homogeneous medium |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1624002A (en) * | 2003-12-04 | 2005-06-08 | 财团法人工业技术研究院 | Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical composition |
CN101418049A (en) * | 2008-12-22 | 2009-04-29 | 山东福瑞达生物化工有限公司 | A kind of hyaluronic preparation method |
-
2017
- 2017-09-26 CN CN201710880823.1A patent/CN107459590B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1624002A (en) * | 2003-12-04 | 2005-06-08 | 财团法人工业技术研究院 | Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical composition |
CN101418049A (en) * | 2008-12-22 | 2009-04-29 | 山东福瑞达生物化工有限公司 | A kind of hyaluronic preparation method |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110790960A (en) * | 2019-11-13 | 2020-02-14 | 华熙生物科技股份有限公司 | Hyaluronic acid quaternary ammonium salt crosslinked powder and preparation method and application thereof |
CN110790960B (en) * | 2019-11-13 | 2023-01-24 | 华熙生物科技股份有限公司 | Hyaluronic acid quaternary ammonium salt crosslinked powder and preparation method and application thereof |
CN114133465A (en) * | 2020-09-03 | 2022-03-04 | 山东华熙海御生物医药有限公司 | Preparation method of potassium hyaluronate, obtained product and application |
CN114133465B (en) * | 2020-09-03 | 2023-03-21 | 山东华熙海御生物医药有限公司 | Preparation method of potassium hyaluronate, obtained product and application |
CN114397399A (en) * | 2021-12-31 | 2022-04-26 | 华熙生物科技股份有限公司 | Method for determining content of quaternary ammonium salt in hyaluronic acid-quaternary ammonium salt polymer |
CN116041565A (en) * | 2022-11-18 | 2023-05-02 | 山东焦点福瑞达生物股份有限公司 | Preparation and purification method of sodium hyaluronate cationic quaternary ammonium salt in homogeneous medium |
CN116041565B (en) * | 2022-11-18 | 2024-02-09 | 山东焦点福瑞达生物股份有限公司 | Preparation and purification method of sodium hyaluronate cationic quaternary ammonium salt in homogeneous medium |
Also Published As
Publication number | Publication date |
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CN107459590B (en) | 2021-03-23 |
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Address after: 250101 678 Tianchen street, hi tech Development Zone, Ji'nan, Shandong Applicant after: BLOOMAGE BIOTECH Co.,Ltd. Applicant after: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. Address before: 250101 678 Tianchen street, hi tech Development Zone, Ji'nan, Shandong Applicant before: BLOOMAGE FREDA BIOPHARM Co.,Ltd. Applicant before: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. |
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Effective date of registration: 20210926 Address after: Tianchen Avenue, Ji'nan hi tech Development Zone of Shandong Province, No. 678 250101 Patentee after: BLOOMAGE BIOTECH Co.,Ltd. Patentee after: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. Patentee after: Huaxi Biotechnology (Tianjin) Co.,Ltd. Address before: Tianchen Avenue, Ji'nan hi tech Development Zone of Shandong Province, No. 678 250101 Patentee before: BLOOMAGE BIOTECH Co.,Ltd. Patentee before: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. |
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Effective date of registration: 20230710 Address after: Tianchen Avenue, Ji'nan hi tech Development Zone of Shandong Province, No. 678 250101 Patentee after: BLOOMAGE BIOTECH Co.,Ltd. Patentee after: Huaxi Biotechnology (Tianjin) Co.,Ltd. Address before: Tianchen Avenue, Ji'nan hi tech Development Zone of Shandong Province, No. 678 250101 Patentee before: BLOOMAGE BIOTECH Co.,Ltd. Patentee before: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. Patentee before: Huaxi Biotechnology (Tianjin) Co.,Ltd. |
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