CN107412332A - A kind of externally applied liniment for treating mastitis and preparation method thereof - Google Patents
A kind of externally applied liniment for treating mastitis and preparation method thereof Download PDFInfo
- Publication number
- CN107412332A CN107412332A CN201710380942.0A CN201710380942A CN107412332A CN 107412332 A CN107412332 A CN 107412332A CN 201710380942 A CN201710380942 A CN 201710380942A CN 107412332 A CN107412332 A CN 107412332A
- Authority
- CN
- China
- Prior art keywords
- mastitis
- externally applied
- treatment
- applied liniment
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000004396 mastitis Diseases 0.000 title claims abstract description 59
- 229940040145 liniment Drugs 0.000 title claims abstract description 49
- 239000000865 liniment Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 51
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 30
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 239000001293 FEMA 3089 Substances 0.000 claims abstract description 19
- 235000007297 Gaultheria procumbens Nutrition 0.000 claims abstract description 19
- 235000012854 Litsea cubeba Nutrition 0.000 claims abstract description 19
- 240000003731 Piper cubeba Species 0.000 claims abstract description 19
- 235000002711 Piper cubeba Nutrition 0.000 claims abstract description 19
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 19
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims abstract description 19
- 240000005528 Arctium lappa Species 0.000 claims abstract description 17
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 17
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims abstract description 17
- 244000078912 Trichosanthes cucumerina Species 0.000 claims abstract description 17
- 240000002262 Litsea cubeba Species 0.000 claims abstract 4
- 239000002893 slag Substances 0.000 claims description 28
- 238000001914 filtration Methods 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 230000001476 alcoholic effect Effects 0.000 claims description 20
- 241000736246 Pyrola Species 0.000 claims description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 14
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 14
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 14
- 229940116229 borneol Drugs 0.000 claims description 14
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 14
- 239000006210 lotion Substances 0.000 claims description 14
- 238000002525 ultrasonication Methods 0.000 claims description 14
- 241000723346 Cinnamomum camphora Species 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 210000005075 mammary gland Anatomy 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 229940126701 oral medication Drugs 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 230000006651 lactation Effects 0.000 abstract description 3
- 231100000614 poison Toxicity 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000003440 toxic substance Substances 0.000 abstract description 3
- 240000001238 Gaultheria procumbens Species 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 19
- 241001081179 Litsea Species 0.000 description 15
- 241000218344 Canella Species 0.000 description 6
- 235000008499 Canella winterana Nutrition 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 206010000269 abscess Diseases 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003447 ipsilateral effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000001287 Galactorrhea Diseases 0.000 description 1
- 206010017600 Galactorrhoea Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004493 neutrocyte Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000062 pectoralis major Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of externally applied liniment for treating mastitis, and per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：The 74mL of d-Bomeol liquid 70, the 10mL of fruit of cubeb litsea tree oil 8, the 5mL of turpentine oil 4, the 5mL of wintergreen 4, the 11mL of auxiliary agent 9；The auxiliary agent is made up of the raw material below according to parts by weight：13 16 parts of Snakegourd Seed, 8 11 parts of great burdock achene.The invention also discloses the preparation method of the externally applied liniment of the treatment mastitis.The externally applied liniment for the treatment of mastitis prepared by the present invention has the effect of removing toxic substances heat-clearing, promoting lactation detumescence, promoting flow of qi and blood circulation, mastitis, significant effect can be effectively treated, and is had no toxic side effect, due to without oral drugs, therefore it disclosure satisfy that the treatment requirement of women breast-feeding their children.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically a kind of externally applied liniment for treating mastitis and preparation method thereof.
Background technology
Mastitis refers to the acute festering type infection of mammary gland, is puerperous common disease, is the reason for causing postpartum fever
One of, it is most commonly in nursing women, especially primipara.The harm of mastitis be it is larger, from the beginning of when mammary swelling, pain,
Lump tenderness, surface is red and swollen, heating；Such as continue to develop, then exacerbation of symptoms, breast throbbing pain；Serious mastitis symptom
Can be with high fever, the performance such as shiver with cold, mastosis is obvious, and local skin is red and swollen, there is scleroma, tenderness, the Ipsilateral under-arm enlargement of lymph node
Greatly, tenderness, inflammation soften within a couple of days, form galactapostema, there is fluctuation, and the deep rubefaction of abscess and fluctuation are failed to understand
Aobvious, after ulceration comes to a head, fester drainage is unobstructed, and can swell to disappear subtracts and more acute mastitis is often accompanied by Ipsilateral axillary gland enlargement bitterly,
There is tenderness；Total white blood cells and the increase of neutrophil leucocyte number.After mastitis, if malpractice harmfulness is just bigger, abscess
It is possible to wear out loose connective tissue before pectoralis major manadesma, forms retromammary abscess；Or milk overflows and formed from wound
Galactorrhea；Pyaemia septica can notably occur.
At present, the treatment for mastitis has oral drugs, hot compress, 0.25% procaine, 60~80 milliliters of mammary gland envelopes
Close, be dissolved in from the oral or intravenous drop of broad-spectrum antibiotic, the unit of penicillin 1,000,000 in 20 milliliters of physiological saline, be injected in inflammation
The therapy such as around disease lump.Because mastitis morbidity highest is women breast-feeding their children, if being injected using oral drugs or Western medicine,
Influence the breast feeding babies of women breast-feeding their children.In addition, oral drugs are difficult to through focus, the effective of lesions position is generally reached
Concentration is relatively low, it is difficult to larger performance therapeutic action, affects the treatment.
The content of the invention
It is an object of the invention to provide a kind of externally applied liniment for treating mastitis and preparation method thereof, to solve the above-mentioned back of the body
The problem of being proposed in scape technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of externally applied liniment for treating mastitis, per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：It is right
Revolve borneol liquid 70-74mL, fruit of cubeb litsea tree oil 8-10mL, turpentine oil 4-5mL, wintergreen 4-5mL, auxiliary agent 9-11mL；The auxiliary agent by
It is made below according to the raw material of parts by weight：Snakegourd Seed 13-16 parts, great burdock achene 8-11 parts.
As the further scheme of the present invention：Per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：Dextrorotation
Borneol liquid 72mL, fruit of cubeb litsea tree oil 9mL, turpentine oil 4.5mL, wintergreen 4.5mL, auxiliary agent 10mL；The auxiliary agent is by below according to weight
The raw material of amount part is made：15 parts of Snakegourd Seed, 9 parts of great burdock achene.
As further scheme of the invention：The d-Bomeol liquid is passed through using the fresh branches and leaves of canella borneol camphor tree
Extraction is processed into.
The preparation method of the externally applied liniment of the treatment mastitis, step are as follows：
1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 30-50 mesh sieves, is merged, obtains mixture；
2) mixture is put into container, adds the water of 10-12 times of weight, soak 3-5h, decoct 2-3h, obtained first and decoct
Boil liquid and first decocts slag, and the first decoction slag is added into the water of 6-8 times of weight again, 1-2h is soaked, decocts 0.5-1h, obtains the
Two decoction liquors and second decoct slag, and the first decoction liquor and the second decoction liquor are merged, filtering, obtain and decoct total liquid, standby；
3) alcoholic solution for decocting slag 3-4 times of weight of addition by second, ultrasonication 40-45min, filtering, is surpassed
Sound wave extract solution, it is standby；
4) total liquid will be decocted with ultrasonic extract to merge, it is 1.20-1.23's to be concentrated by evaporation as relative density at 60 DEG C
Lotion, and lotion is added in the alcoholic solution of 2 times of weight, stir evenly, stand 15-20h, filtration, take filtrate, you can helped
Agent；
5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment
The externally applied liniment of mastitis.
As further scheme of the invention：The alcoholic solution is the alcohol water blend of volumetric concentration 70%.
As further scheme of the invention：In step 3), the ultrasonication power is 1000W.
Compared with prior art, the beneficial effects of the invention are as follows：
The externally applied liniment for the treatment of mastitis prepared by the present invention has the effect of removing toxic substances heat-clearing, promoting lactation detumescence, promoting flow of qi and blood circulation,
Mastitis, significant effect can be effectively treated, and is had no toxic side effect；The externally applied liniment for the treatment of mastitis prepared by the present invention uses
It is convenient, cleaned by external application, due to without oral drugs, therefore disclosure satisfy that the treatment requirement of women breast-feeding their children.
Embodiment
Technical scheme is described in more detail with reference to embodiment.
Embodiment 1
A kind of externally applied liniment for treating mastitis, per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：It is right
Revolve borneol liquid 70mL, fruit of cubeb litsea tree oil 10mL, turpentine oil 5mL, wintergreen 5mL, auxiliary agent 10mL；The auxiliary agent is by below according to weight
The raw material of part is made：13 parts of Snakegourd Seed, 8 parts of great burdock achene；Wherein, the d-Bomeol liquid is using the fresh of canella borneol camphor tree
Branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment mastitis, step is as follows：
1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 30 mesh sieves, is merged, obtains mixture；
2) mixture is put into container, add 10 times of weight water, soak 3h, decoct 2h, obtain the first decoction liquor and
First decocts slag, and the first decoction slag is added into the water of 6 times of weight again, 1h is soaked, decocts 0.5h, obtains the second decoction liquor and the
Two decoct slag, and the first decoction liquor and the second decoction liquor are merged, filtering, obtain and decoct total liquid, standby；
3) alcoholic solution for decocting slag 3 times of weight of addition by second, ultrasonication 40min, filtering, obtain ultrasonic wave and carry
Liquid is taken, it is standby, wherein, the ultrasonication power is 1000W；
4) total liquid will be decocted with ultrasonic extract to merge, and will be concentrated by evaporation the lotion for being 1.20 for relative density at 60 DEG C,
And add lotion in the alcoholic solution of 2 times of weight, stir evenly, stand 15h, filtration, take filtrate, you can obtain auxiliary agent；
5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment
The externally applied liniment of mastitis；
Above-mentioned alcoholic solution is the alcohol water blend of volumetric concentration 70%.
Embodiment 2
A kind of externally applied liniment for treating mastitis, per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：It is right
Revolve borneol liquid 74mL, fruit of cubeb litsea tree oil 8mL, turpentine oil 4mL, wintergreen 4mL, auxiliary agent 10mL；The auxiliary agent is by below according to weight
The raw material of part is made：14 parts of Snakegourd Seed, 10 parts of great burdock achene；Wherein, the d-Bomeol liquid is using the new of canella borneol camphor tree
Fresh branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment mastitis, step is as follows：
1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 35 mesh sieves, is merged, obtains mixture；
2) mixture is put into container, adds the water of 11 times of weight, soak 3.5h, decoct 2h, obtain the first decoction liquor
Slag is decocted with first, the first decoction slag is added to the water of 6 times of weight again, 1.5h is soaked, decocts 0.5h, obtain the second decoction liquor
Slag is decocted with second, the first decoction liquor and the second decoction liquor are merged, filtering, obtains and decocts total liquid, it is standby；
3) alcoholic solution for decocting slag 3 times of weight of addition by second, ultrasonication 41min, filtering, obtain ultrasonic wave and carry
Liquid is taken, it is standby, wherein, the ultrasonication power is 1000W；
4) total liquid will be decocted with ultrasonic extract to merge, and will be concentrated by evaporation the lotion for being 1.21 for relative density at 60 DEG C,
And add lotion in the alcoholic solution of 2 times of weight, stir evenly, stand 16h, filtration, take filtrate, you can obtain auxiliary agent；
5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment
The externally applied liniment of mastitis；
Above-mentioned alcoholic solution is the alcohol water blend of volumetric concentration 70%.
Embodiment 3
A kind of externally applied liniment for treating mastitis, per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：It is right
Revolve borneol liquid 72mL, fruit of cubeb litsea tree oil 9mL, turpentine oil 4.5mL, wintergreen 4.5mL, auxiliary agent 10mL；The auxiliary agent by below according to
The raw material of parts by weight is made：15 parts of Snakegourd Seed, 9 parts of great burdock achene；Wherein, the d-Bomeol liquid is using canella borneol camphor tree
Fresh branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment mastitis, step is as follows：
1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 40 mesh sieves, is merged, obtains mixture；
2) mixture is put into container, adds the water of 11 times of weight, soak 4h, decoct 2.5h, obtain the first decoction liquor
Decoct slag with first, the first decoction slag added into the water of 7 times of weight again, 1.5h is soaked, decocts 1h, obtain the second decoction liquor and
Second decocts slag, and the first decoction liquor and the second decoction liquor are merged, filtering, obtains and decocts total liquid, standby；
3) alcoholic solution for decocting slag 4 times of weight of addition by second, ultrasonication 43min, filtering, obtain ultrasonic wave and carry
Liquid is taken, it is standby, wherein, the ultrasonication power is 1000W；
4) total liquid will be decocted with ultrasonic extract to merge, and will be concentrated by evaporation the lotion for being 1.22 for relative density at 60 DEG C,
And add lotion in the alcoholic solution of 2 times of weight, stir evenly, stand 18h, filtration, take filtrate, you can obtain auxiliary agent；
5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment
The externally applied liniment of mastitis；
Above-mentioned alcoholic solution is the alcohol water blend of volumetric concentration 70%.
Embodiment 4
A kind of externally applied liniment for treating mastitis, per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：It is right
Revolve borneol liquid 73mL, fruit of cubeb litsea tree oil 9mL, turpentine oil 4.5mL, wintergreen 4.5mL, auxiliary agent 9mL；The auxiliary agent is by below according to weight
The raw material of amount part is made：15 parts of Snakegourd Seed, 11 parts of great burdock achene；Wherein, the d-Bomeol liquid is using canella borneol camphor tree
Fresh branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment mastitis, step is as follows：
1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 45 mesh sieves, is merged, obtains mixture；
2) mixture is put into container, adds the water of 11 times of weight, soak 4.5h, decoct 2.5h, obtained first and decoct
Liquid and first decocts slag, and the first decoction slag is added into the water of 7 times of weight again, 2h is soaked, decocts 1h, obtain the second decoction liquor and
Second decocts slag, and the first decoction liquor and the second decoction liquor are merged, filtering, obtains and decocts total liquid, standby；
3) alcoholic solution for decocting slag 4 times of weight of addition by second, ultrasonication 43min, filtering, obtain ultrasonic wave and carry
Liquid is taken, it is standby, wherein, the ultrasonication power is 1000W；
4) total liquid will be decocted with ultrasonic extract to merge, and will be concentrated by evaporation the lotion for being 1.23 for relative density at 60 DEG C,
And add lotion in the alcoholic solution of 2 times of weight, stir evenly, stand 17h, filtration, take filtrate, you can obtain auxiliary agent；
5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment
The externally applied liniment of mastitis；
Above-mentioned alcoholic solution is the alcohol water blend of volumetric concentration 70%.
Embodiment 5
A kind of externally applied liniment for treating mastitis, per 100mL, the raw material composition of the externally applied liniment for the treatment of mastitis is as follows：It is right
Revolve borneol liquid 72mL, fruit of cubeb litsea tree oil 8mL, turpentine oil 4.5mL, wintergreen 4.5mL, auxiliary agent 11mL；The auxiliary agent by below according to
The raw material of parts by weight is made：16 parts of Snakegourd Seed, 11 parts of great burdock achene；Wherein, the d-Bomeol liquid uses canella borneol camphor tree
Fresh branches and leaves extracted be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment mastitis, step is as follows：
1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 50 mesh sieves, is merged, obtains mixture；
2) mixture is put into container, add 12 times of weight water, soak 5h, decoct 3h, obtain the first decoction liquor and
First decocts slag, and the first decoction slag is added to the water of 8 times of weight again, 2h is soaked, decocts 1h, obtain the second decoction liquor and second
Slag is decocted, the first decoction liquor and the second decoction liquor are merged, filtering, obtains and decocts total liquid, it is standby；
3) alcoholic solution for decocting slag 4 times of weight of addition by second, ultrasonication 45min, filtering, obtain ultrasonic wave and carry
Liquid is taken, it is standby, wherein, the ultrasonication power is 1000W；
4) total liquid will be decocted with ultrasonic extract to merge, and will be concentrated by evaporation the lotion for being 1.23 for relative density at 60 DEG C,
And add lotion in the alcoholic solution of 2 times of weight, stir evenly, stand 20h, filtration, take filtrate, you can obtain auxiliary agent；
5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment
The externally applied liniment of mastitis；
Above-mentioned alcoholic solution is the alcohol water blend of volumetric concentration 70%.
The externally applied liniment of present invention treatment mastitis is used as major ingredient using d-Bomeol liquid, and 28 kinds are contained in d-Bomeol liquid
Active ingredient, can anti-inflammatory, analgesic, detumescence, promoting blood circulation and removing blood stasis, penetration is strong, using fruit of cubeb litsea tree oil, turpentine oil, wintergreen and helps
Agent as auxiliary material, wintergreen can relaxing tendons and activating collaterals, increase blood circulation, analgesic antiphlogistic, compatibility d-Bomeol liquid energy is enough strengthened oozing
Saturating dynamics, turpentine oil can permeate capillary, anti-inflammatory, qualcomm meridian, blood-activating analgetic, and fruit of cubeb litsea tree oil compatibility d-Bomeol liquid energy reaches
Anti inflammation, detumescence and relieving pain, auxiliary agent can strengthen therapeutic effect of the externally applied liniment to mastitis.
125 mastitis patients are treated, cure rate reaches by the externally applied liniment of present invention treatment mastitis
56%, total effective rate has reached more than 94%, significant effect.
The externally applied liniment for the treatment of mastitis prepared by the present invention has the effect of removing toxic substances heat-clearing, promoting lactation detumescence, promoting flow of qi and blood circulation,
Mastitis, significant effect can be effectively treated, and is had no toxic side effect；The externally applied liniment for the treatment of mastitis prepared by the present invention uses
It is convenient, cleaned by external application, due to without oral drugs, therefore disclosure satisfy that the treatment requirement of women breast-feeding their children.
The better embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula, can also be on the premise of present inventive concept not be departed from one skilled in the relevant art's possessed knowledge
Various changes can be made.
Claims (6)
- A kind of 1. externally applied liniment for treating mastitis, it is characterised in that the raw material group of the externally applied liniment for the treatment of mastitis per 100mL Into as follows：D-Bomeol liquid 70-74mL, fruit of cubeb litsea tree oil 8-10mL, turpentine oil 4-5mL, wintergreen 4-5mL, auxiliary agent 9-11mL；Institute Auxiliary agent is stated to be made up of the raw material below according to parts by weight：Snakegourd Seed 13-16 parts, great burdock achene 8-11 parts.
- 2. the externally applied liniment for the treatment of mastitis according to claim 1, it is characterised in that the treatment mastitis per 100mL The raw material composition of externally applied liniment is as follows：D-Bomeol liquid 72mL, fruit of cubeb litsea tree oil 9mL, turpentine oil 4.5mL, wintergreen 4.5mL, help Agent 10mL；The auxiliary agent is made up of the raw material below according to parts by weight：15 parts of Snakegourd Seed, 9 parts of great burdock achene.
- 3. the externally applied liniment for the treatment of mastitis according to claim 1, it is characterised in that the d-Bomeol liquid uses camphor tree The fresh branches and leaves of section plant borneol camphor tree are extracted to be processed into.
- A kind of 4. preparation method of the externally applied liniment for the treatment of mastitis as described in claim 1-3 is any, it is characterised in that step It is rapid as follows：1) Snakegourd Seed, great burdock achene are weighed, is cleaned, is dried, is crushed, crosses 30-50 mesh sieves, is merged, obtains mixture；2) mixture is put into container, adds the water of 10-12 times of weight, soak 3-5h, decoct 2-3h, obtain the first decoction liquor Slag is decocted with first, the first decoction slag is added to the water of 6-8 times of weight again, 1-2h is soaked, decocts 0.5-1h, second is obtained and decocts Boil liquid and second decocts slag, and the first decoction liquor and the second decoction liquor are merged, filtering, obtains and decocts total liquid, standby；3) alcoholic solution for decocting slag 3-4 times of weight of addition by second, ultrasonication 40-45min, filtering, obtains ultrasonic wave Extract solution, it is standby；4) total liquid will be decocted with ultrasonic extract to merge, and will be concentrated by evaporation the lotion for being 1.20-1.23 for relative density at 60 DEG C, And add lotion in the alcoholic solution of 2 times of weight, stir evenly, stand 15-20h, filtration, take filtrate, you can obtain auxiliary agent；5) d-Bomeol liquid, fruit of cubeb litsea tree oil, turpentine oil, wintergreen and auxiliary agent are taken according to formula, is well mixed, produces treatment mammary gland Scorching externally applied liniment.
- 5. the preparation method of the externally applied liniment for the treatment of mastitis according to claim 4, it is characterised in that the alcohol is molten Liquid is the alcohol water blend of volumetric concentration 70%.
- 6. the preparation method of the externally applied liniment for the treatment of mastitis according to claim 4, it is characterised in that in step 3), The ultrasonication power is 1000W.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710380942.0A CN107412332A (en) | 2017-05-25 | 2017-05-25 | A kind of externally applied liniment for treating mastitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710380942.0A CN107412332A (en) | 2017-05-25 | 2017-05-25 | A kind of externally applied liniment for treating mastitis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107412332A true CN107412332A (en) | 2017-12-01 |
Family
ID=60429119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710380942.0A Pending CN107412332A (en) | 2017-05-25 | 2017-05-25 | A kind of externally applied liniment for treating mastitis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107412332A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091136A (en) * | 2011-03-18 | 2011-06-15 | 钟志勇 | Traditional Chinese medicine composition--external tincture for gall and preparation method thereof |
| CN105233187A (en) * | 2015-11-24 | 2016-01-13 | 林子莉 | External use finish treating breast diseases and preparation method thereof |
-
2017
- 2017-05-25 CN CN201710380942.0A patent/CN107412332A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091136A (en) * | 2011-03-18 | 2011-06-15 | 钟志勇 | Traditional Chinese medicine composition--external tincture for gall and preparation method thereof |
| CN105233187A (en) * | 2015-11-24 | 2016-01-13 | 林子莉 | External use finish treating breast diseases and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李强 等: "《新编常用中药有效成分手册》", 31 January 2008, 中国协和医科大学出版社 * |
| 李新: "《妇产科疾病专家经典处方 第2版》", 31 March 2014, 人民军医出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101069723A (en) | Oral liquor of anti-fatigue and intensifying immunity and preparing method | |
| CN102895410A (en) | Health-strengthening donkey-hide gelatin jelly for females | |
| CN105194308A (en) | Health-preserving medicinal liquor and preparing method thereof | |
| CN103893283B (en) | A kind of Chinese medicine composition for treating chronic kidney disease and chronic kidney hypofunction and preparation method thereof | |
| CN101804175B (en) | Anti-cancer Chinese medicinal powder and preparation method thereof | |
| CN107412332A (en) | A kind of externally applied liniment for treating mastitis and preparation method thereof | |
| CN103432533B (en) | Traditional Chinese medicine for treating perianal abscess | |
| CN103223158B (en) | External medicine for treating alopecia | |
| CN106620402A (en) | Traditional Chinese medicine composition taken after operation of liver cancer and preparation method thereof | |
| CN105362549A (en) | Ointment with effects of promoting blood circulation, relieving swelling and stopping pain | |
| CN1059823C (en) | Medicinal liquor for body-building and treating rheumatism | |
| CN104887896B (en) | Chinese medicine composition and the massage cream and preparation method thereof for treating cyclomastopathy | |
| CN105770515A (en) | Traditional Chinese medicinal composition for treating prostatitis and preparation method of traditional Chinese medicinal composition | |
| CN105125722A (en) | Orally-taken traditional Chinese medicine composition for treating functional uterine bleeding and preparation method | |
| CN105168752A (en) | Orally-taken medicine for treating chronic myeloid leukemia and preparation method of medicine | |
| CN105477246A (en) | Traditional Chinese medicine composition for treating phlegmatic hygrosis type mammary gland hyperplasia and preparation method thereof | |
| CN104971181A (en) | Vocal cord polyp treatment medicine and preparation method thereof | |
| CN104887825A (en) | Traditional Chinese medicine prescription for curing eczema and preparation method thereof | |
| CN111759965A (en) | Acupoint application plaster for treating hyperplasia of mammary glands and preparation method thereof | |
| CN103110822B (en) | Preparation method of traditional Chinese medicine for treating liver and kidney deficiency retinitis | |
| CN111686182A (en) | Chinese medicinal composition for removing blood stasis and relieving pain and preparation method thereof | |
| CN104560509A (en) | Health-maintenance medicinal wine for enriching blood and nourishing qi | |
| CN102100860A (en) | Chinese medicine preparation used for treating mammitis | |
| CN103040899B (en) | Traditional Chinese medicine noninvasive-drug for anal fistula and preparation method and use method thereof | |
| CN101623472A (en) | Chinese medicinal composition for treating agrypnia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200527 Address after: 343000 lot b12-15-2, Hedong Economic Development Zone, Jinggangshan economic and Technological Development Zone, Ji'an City, Jiangxi Province Applicant after: Jiangxi Wenxu Biotechnology Co., Ltd Address before: 332000 Jiangxi province Jiujiang Duchang County Mingshan Township Chenglang Village Applicant before: JIANGXI SHANYOU LONGNAO TECHNOLOGY Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171201 |
|
| RJ01 | Rejection of invention patent application after publication |