CN107411996A - A kind of facial mask of the fiber containing silk fibroin - Google Patents
A kind of facial mask of the fiber containing silk fibroin Download PDFInfo
- Publication number
- CN107411996A CN107411996A CN201710351526.8A CN201710351526A CN107411996A CN 107411996 A CN107411996 A CN 107411996A CN 201710351526 A CN201710351526 A CN 201710351526A CN 107411996 A CN107411996 A CN 107411996A
- Authority
- CN
- China
- Prior art keywords
- facial mask
- silk fibroin
- fiber
- fiber containing
- containing silk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a kind of facial mask of fiber containing silk fibroin, the facial mask, which by silk fibroin fiber is made film-form and is compounded in the substrate of facial mask, to be formed, or described silk fibroin is supported on the facial mask that the fiber containing silk fibroin is formed in the fibrous framework of facial mask.Also contain chitosan or chitin composition in the fibrous framework of described facial mask.The product of the present invention does not contain the exogenous toxicity, side effect material brought into due to preparation technology.Using effect is good.Necessary nutrition is provided to improve the activity of face cell.
Description
Technical field
The present invention relates to a kind of facial mask of fiber containing silk fibroin, belongs to technical field prepared by auxotype facial mask.
Background technology
Existing facial mask is typically all the facial mask for being coated in medicine and certain special treatment function being made in the substrate of papery, this
Kind facial mask is non-serviceable, does not play the effect of beauty after use not only, can draw on the contrary for the people of some easy allergy
Rise allergic.Native protein silk is that the traditional feeding product in China is also principal item in azelon, fibroin albumen
Account for silk weight 70% -80%. it be substantial material that people utilize.Fibroin albumen is made up of 18 kinds of amino acid, through reality
Test research and show that it has that good bioaffinity is nontoxic, it is pollution-free, it is biodegradable, according to literature search, both at home and abroad,
It has not been found that preparing facial mask with silk fibroin is used for beauty.Natural silk, it is natural degradable material, with people
Body has good biocompatibility.Obtained product does not contain the exogenous toxicity, side effect material brought into due to preparation technology.
The content of the invention
Technical problem：It is good it is an object of the invention to provide a kind of using effect, there is good bio-compatible with human body
Property and with excellent biodegradability the fiber containing silk fibroin facial mask.
Technical scheme：Film-form is made by silk fibroin fiber in the facial mask of the fiber containing silk fibroin of the present invention
It is compounded in the substrate of facial mask and forms.
Or described silk fibroin is supported in the fibrous framework of facial mask and forms the fiber containing silk fibroin
Facial mask.
Wherein：Also contain chitosan or chitin composition in the fibrous framework of described facial mask.
Beneficial effect：The product material therefor of the present invention is high-purity natural silk, and it is natural degradable material, with
Human body has good biocompatibility.Obtained product does not contain the exogenous toxicity, side effect thing brought into due to preparation technology
Matter.Using effect is good.Necessary nutrition is provided to improve the activity of face cell, while the product has good biofacies
Capacitive.
Embodiment
The preparation method of the facial mask of the fiber containing silk fibroin of the present invention is as follows：
Silk fibroin fiber is made in silk by step 1.：Silk is molten in the weak base that volumetric concentration is 0.1~10%
50 DEG C~100 DEG C heating, then clean the fiber after processing with distilled water to obtain silk fibroin fiber in liquid；
Silk fibroin fiber is prepared film-like by step 2.：By the part silk fibroin fiber of above-mentioned preparation in
At 25-80 DEG C, it is dissolved in the ternary system of calcium chloride, second alcohol and water, dissolution time is 0.5~6 hour, by the mixing of dissolving
Solution loads cellulose membrane bag, is dialysed with distilled water；Then the silk fibroin solution after dialysis is injected into mould, carried out into after drying
Type is processed；The silk fibroin fiber membrane of first one-step forming is put into methanol again and sodium hydroxide solution is handled, then successively
Cleaned with sodium hydroxide solution, phosphate buffer and distilled water, obtain silk fibroin fiber membrane；
Described silk fibroin fiber composite in the substrate surface of facial mask, or is supported on the fiber of facial mask by step 3.
The facial mask of the fiber containing silk fibroin is formed in support.
Wherein：
Described to be dissolved in the ternary system of calcium chloride, second alcohol and water, mol ratio is calcium chloride：Ethanol：Water=1：2：8.
In step 3, constituent of chitosan is additionally added in the fibrous framework of the facial mask, i.e., is embedded in silk fibroin fiber
Polyglycolic acid, PLA, constituent of chitosan facial mask substrate in；Specifically chitosan is dissolved in weak acid solution, volume is dense
Spend for 2~15%, solution is then processed into chitin fiber by wet spinning technology；Obtained chitin fiber is put again
Enter and acetylization reaction is carried out in the alcoholic solution of aceticanhydride, reaction temperature is 0~60 DEG C, and the reaction time is 0.5~6 hour；Acetylation
Cleaned after reaction with water, be then placed in 1-2mol/L sodium hydroxide or potassium hydroxide solution, cleaned up with water, after drying
Obtain the fibrous framework of the facial mask of chitosan-containing.
Described weak acid is acetic acid, phosphoric acid, citric acid or lactic acid.
In the alcoholic solution of described aceticanhydride, wherein, the volumetric concentration of aceticanhydride is 1~50%, and alcoholic solution is methanol or ethanol.
With reference to embodiment, the invention will be further described.
Embodiment 1：
The preparation of step 1. silk fibroin fiber：By silk in the weak caustic solution (sodium carbonate of volumetric concentration 0.1~10%
Or 0.1~10% potassium carbonate) in 50~100 DEG C of heating, then the fiber after processing is cleaned with distilled water to obtain silk
Fibroin fiber, a part for the silk fibroin fiber is used for step 2, another part enters as fibrous framework
Enter step 3 to use；
The preparation of step 2. silk fibroin fiber membrane：By the part silk fibroin fiber of above-mentioned preparation in
At 25-80 DEG C, it is dissolved in the ternary system of calcium chloride, second alcohol and water that (mol ratio is calcium chloride：Ethanol：Water=1：2：8) it is, molten
It is 0.5~6 hour to solve the time, and the mixed solution of dissolving is loaded into cellulose membrane bag, dialysed with distilled water；Then by after dialysis
Silk fibroin solution injects mould, carries out processing and forming after drying；The silk fibroin fiber membrane of first one-step forming is put into again
50：50 (V/V) methanol and sodium hydroxide (1mol/L) solution is handled 5 minutes~2 hours, then successively uses sodium hydroxide
(1mol/L) solution, 50mmol/L phosphate buffers and distilled water cleaning, obtain silk fibroin fiber membrane；
Step 3. combines：Silk fibroin fiber Embedded step 2 made from step 1 is obtained containing the thin of fibroin albumen
In film, the facial mask of the fiber containing silk fibroin is combined into.
Embodiment 2：
Step 1, step 2 with embodiment 1,
Step 3. (example polyglycolic acid (PGA), gathers embedded other materials in the film containing fibroin albumen made from step 2
Lactic acid (PLA), chitosan, chitin) fibrous framework is made.
Fibrous framework method is made in chitin：Chitosan is dissolved in weak acid solution, weak acid is acetic acid, phosphoric acid, lemon
Lemon acid or lactic acid, volumetric concentration are 2~15%, and solution then is processed into chitin fiber by wet spinning technology；Again will
Obtained chitin fiber, which is put into the alcoholic solution of aceticanhydride, carries out acetylization reaction, and reaction temperature is 0~60 DEG C, and the reaction time is
0.5~6 hour.In the alcoholic solution of aceticanhydride, the volumetric concentration of aceticanhydride is 1~50%, and alcoholic solution is methanol or ethanol.Acetylation is anti-
Should after cleaned with water, be then placed in 1mol/L sodium hydroxide or potassium hydroxide solution 24 hours, cleaned up with water, dry
The fibrous framework of the facial mask of chitosan-containing is obtained afterwards.
Claims (3)
1. a kind of facial mask of fiber containing silk fibroin, it is characterized in that：Film is made by silk fibroin fiber in the facial mask
Shape is compounded in the substrate of facial mask and formed.
2. the facial mask of the fiber according to claim 1 containing silk fibroin, it is characterized in that：Described silk fibroin
It is supported on the facial mask that the fiber containing silk fibroin is formed in the fibrous framework of facial mask.
3. the facial mask of the fiber according to claim 2 containing silk fibroin, it is characterized in that：The fiber branch of described facial mask
Also contain chitosan or chitin composition in frame.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710351526.8A CN107411996A (en) | 2017-05-18 | 2017-05-18 | A kind of facial mask of the fiber containing silk fibroin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710351526.8A CN107411996A (en) | 2017-05-18 | 2017-05-18 | A kind of facial mask of the fiber containing silk fibroin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107411996A true CN107411996A (en) | 2017-12-01 |
Family
ID=60424725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710351526.8A Pending CN107411996A (en) | 2017-05-18 | 2017-05-18 | A kind of facial mask of the fiber containing silk fibroin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107411996A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686061A (en) * | 2005-04-26 | 2005-10-26 | 南通大学 | Chitin contained medical nerve graft and its preparation method |
| CN1742690A (en) * | 2005-09-28 | 2006-03-08 | 南通大学 | Medical nerve transplant containing silk element and preparing method |
| CN101829025A (en) * | 2010-04-27 | 2010-09-15 | 马兆成 | Bioactive facial mask and preparation method therefore |
| CN104672316A (en) * | 2015-02-11 | 2015-06-03 | 苏州丝美特生物技术有限公司 | Preparation and identification method of domestic silkworm silk fibroin solution |
-
2017
- 2017-05-18 CN CN201710351526.8A patent/CN107411996A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686061A (en) * | 2005-04-26 | 2005-10-26 | 南通大学 | Chitin contained medical nerve graft and its preparation method |
| CN1742690A (en) * | 2005-09-28 | 2006-03-08 | 南通大学 | Medical nerve transplant containing silk element and preparing method |
| CN101829025A (en) * | 2010-04-27 | 2010-09-15 | 马兆成 | Bioactive facial mask and preparation method therefore |
| CN104672316A (en) * | 2015-02-11 | 2015-06-03 | 苏州丝美特生物技术有限公司 | Preparation and identification method of domestic silkworm silk fibroin solution |
Non-Patent Citations (1)
| Title |
|---|
| 崔淑玲: "《高技术纤维》", 30 September 2016 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171201 |
|
| RJ01 | Rejection of invention patent application after publication |